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Multiscale

Sebastian Schmieschek edited this page Aug 12, 2015 · 2 revisions

Things to try

  • Model an injection in HemeLB either through an inlet or by creating fluid in certain places.
  • HemeLB Thrombus

General ideas

  • HemeLB - HemeLB coupling
  • HemeLB - PyNS coupling (arch project)
  • HemeLB - Jussi Timonen's particle code coupling
  • HemeLB - Thrombus coupling

Piece-by-Piece Workplan

Phase 1 Homogeneous coupling - Two parallel tracks

1A: Couple PyNS with PyNS using the MPWide Python API.

  • Develop Python API for MPWide.
  • Model individual sections of the Circle of Willis using different instances of PyNS.
  • Develop the coupling mechanism in PyNS.
  • Define a mechanism to specify coupling boundaries for PyNS.

1B: Couple HemeLB with HemeLB using the MPWide Intercommunicator.

  • Write the intercommunicator.
  • Define and test a simple coupling problem (e.g. long cylinder).
  • Define and test a realistic coupling problem.

Phase 2 Cross-code coupling - At least three parallel tracks

2A: Developing HemeLB - PyNS coupling

2B: Deploying the coupling on a production infrastructure and testing/optimizing the coupling performance (start of a CS paper?)

2C: Initial Validation of the coupling mechanisms for physical correctness

  • Should result in a number of suggestions for improvement.

''' (Optional: get started on some of the general ideas mentioned above?) e.g.:

  • HemeLB - Jussi Timonen's particle code coupling
  • HemeLB - Thrombus coupling

Paper resources

The influence of contrastagentinjection on physiologicalflow in the circle of Willis G. Mulder, A.C.B. Bogaerds, P. Rongen, F.N. van de Vosse http://www.sciencedirect.com/science/article/pii/S1350453310002171

Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows J. Alastrueya, K.H. Parker, J. Peiróa, S.M. Byrdc, S.J. Sherwina http://www.sciencedirect.com/science/article/pii/S0021929006002946

Validation of a one-dimensional model of the systemic arterial tree Philippe Reymond, Fabrice Merenda, Fabienne Perren, Daniel Rüfenacht, and Nikos Stergiopulos http://ajpheart.physiology.org/content/297/1/H208.short

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