We decided to use for analysis the following datasets
1.https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE219208
2.https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE223269
3.https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97356
4.https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109409
article reference GSE97356 https://www.nature.com/articles/s41398-017-0050-1