Version 2.0.5

• Fix for nlmixrSim CMT to have a factor that matches the RxODE
  definition (issue #501)

• Give instructions on how to reinstall nlmixr if it is linked to a
  different version of RxODE. (#555)

• Now inform which parameters are near the boundary (#544)

• The saem estimation routine will now increase the tolerance when
  ODE solving is difficult; This can be controlled with
  odeRecalcFactors and maxOdeRecalc. This is similar to the
  handling that focei already uses.

• For focei family estimation methods:

  • If the inner problem couldn't solve the ODE using the forward
    sensitivities, try using numerical differences to approximate the
    derivatives needed for the focei problem. A warning will be
    issued when this occurs. This requires RxODE 1.1.0 that always
    generates the finite difference prediction model. If RxODE is an
    earlier version, only apply this when the finite differences are
    supplied to nlmixr. This occurs when there are ETAs on the dose
    based events like duration, lag time, bioavaibility etc.

  • If eta nudge is non-zero, when resetting an ETA estimate, try the
    zero estimate first, and then the nudged locations.

  • When there is an ODE system for an individual that cannot be
    optimized in the inner problem, adjust that individual's objective
    function by 100 points. This can be controlled by
    foceiControl(badSolveObjfAdj=100)

  • Theta reset now will now make sure the parameter is estimated and
    between the proper bounds before resetting.

• $simInfo non longer tries to generate the covariance step, and
  will simply have a $simInfo$thetaMat entry of NULL if the
  covariance step was unsuccessful.

• With vpc() if the cmt conversion isn't working correctly, fall
  back to compartment numbers.

• Take out symbol stripping based on CRAN policies

• Fall back gracefully when rbind doesn't work in parameter
  histories.

• Correctly print out the number of compartments based on the new
  RxODE linCmt() that was updated to support solved systems in
  focei. (Reported by Bill Denney #537).

• Use strict headers since Rcpp now is moving toward strict headers.
  Also changed all the Calloc to R_Calloc, Free to R_Free,
  and DOUBLE_EPS to DBL_EPSILON.

• gnlmm no longer imports the data.frame to an RxODE event table.
  This should speed up the routine slightly and (more importantly)
  make it easier to specify time varying covariates.

nlmixr 2.0.4

• Now can use the following for combinde error models:
  foceiControl(addProp=1) foceiControl(addProp=2)
saemControl(addProp=1) saemControl(addProp=2)

• Bug-fix for SAEM add+prop and other error models that are optimized
  with nelder mead simplex (#503)

• Bug-fix for more complex SAEM models that were not parsing and running. (Issue
  #502, #501)

• Issue the "NaN in prediction" once per SAEM problem (#500)