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Update 2024-1-31-new-year.md
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adelavega authored Feb 2, 2024
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Expand Up @@ -19,7 +19,7 @@ A key feature that set Neurosynth aside were large-scale association maps (previ

Whereas a typical meta-analysis tells you if activity is consistently reported in a target set of studies, an association test tells you if **activation occurs more consistently in this set of studies versus a large and diverse reference sample**.

That's important, because this allows you to control for base rate differences between regions. Certain regions, such as the insula or lateral PFC for instance, play a very broad role in cognition, and hence are consistently activated for many different tasks and cognitive states. Thus, if you see insula activity in your meta-analysis, you might erroneously conclude that the insula is involved in the cognitive state you're studying. A large-scale association test lets you determine if the activity you observe in a region occurs *more consistently* in your meta-analysis than in other studies, making it possible to make more confident claims that a given region is involved in a particular process, and isn't involved in just about every task.
That's important, because this allows you to control for base rate differences between regions. Certain regions, such as the insula or lateral PFC for instance, play a very broad role in cognition, and hence are consistently activated for many different tasks and cognitive states. Using MKDA Chi-Squared, you can test if brain activity in a region (such as the insula) is specifically associated with the studies in your meta-analysis.

Previously association tests were available for the automatically generated maps on neurosynth.org. **Now you can perform large-scale association tests for your custom meta-analyses in Neurosynth Compose.**

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