We designed BioNAR to support a range of network analysis functionality, complementing existing R packages and filling the methodological gaps necessary to interrogate biomedical networks with respect to functional and disease domains. For that purpose, we do not implement network reconstruction directly (unless for synaptic networks), as other tools such as Cytoscape and Network Analyst do this already. Rathher, we provide a detailed topologically-based network analysis package, enabling the researcher to load networks generated from the lab’s own meta-data, thus making the tool as widely applicable and flexible as possible. We also provide a synaptic proteome network of our own for validation.
You can install the development version of BioNAR from GitHub with:
# install.packages("devtools")
devtools::install_github("lptolik/BioNAR")Detailed description of the functionality and examples are provided in the package vignette:
library(BioNAR)
vignette("BioNAR_overview")If you are using this package, please cite the following paper:
Mclean C, Sorokin A, Simpson TI, Armstrong JD, Sorokina O (2023). “BioNAR: An Integrated Biological Network Analysis Package in Bioconductor.” Bioinformatics Advances, vbad137. doi:10.1093/bioadv/vbad137 https://doi.org/10.1093/bioadv/vbad137.