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kkrismer committed May 3, 2020
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# IDR2D: Irreproducible Discovery Rate for Genomic Interactions

[![license: MIT](https://img.shields.io/badge/license-MIT-blue.svg)](https://opensource.org/licenses/MIT) [![Travis build status](https://travis-ci.org/kkrismer/idr2d.svg?branch=master)](https://travis-ci.org/kkrismer/idr2d) [![DOI](https://img.shields.io/badge/DOI-10.1101%2F691295-blue.svg)](https://doi.org/10.1093/nar/gkaa030) [![BioC](https://img.shields.io/badge/BioC-1.0.4-brightgreen.svg)](https://doi.org/doi:10.18129/B9.bioc.idr2d) [![platforms](https://www.bioconductor.org/shields/availability/3.11/idr2d.svg)](https://www.bioconductor.org/packages/release/bioc/html/idr2d.html#archives) [![Coverage Status](https://coveralls.io/repos/github/kkrismer/idr2d/badge.svg?branch=master)](https://coveralls.io/github/kkrismer/idr2d?branch=master)
[![license: MIT](https://img.shields.io/badge/license-MIT-blue.svg)](https://opensource.org/licenses/MIT) [![Travis build status](https://travis-ci.org/kkrismer/idr2d.svg?branch=master)](https://travis-ci.org/kkrismer/idr2d) [![DOI](https://img.shields.io/badge/DOI-10.1101%2F691295-blue.svg)](https://doi.org/10.1093/nar/gkaa030) [![BioC](https://img.shields.io/badge/BioC-1.2.1-brightgreen.svg)](https://doi.org/doi:10.18129/B9.bioc.idr2d) [![platforms](https://www.bioconductor.org/shields/availability/3.11/idr2d.svg)](https://www.bioconductor.org/packages/release/bioc/html/idr2d.html#archives) [![Coverage Status](https://coveralls.io/repos/github/kkrismer/idr2d/badge.svg?branch=master)](https://coveralls.io/github/kkrismer/idr2d?branch=master)

Chromatin interaction data from protocols such as ChIA-PET and HiChIP provide valuable insights into genome organization and gene regulation, but can include spurious interactions that do not reflect underlying genome biology. We introduce a generalization of the Irreproducible Discovery Rate (IDR) method called IDR2D that identifies replicable interactions shared by experiments. IDR2D provides a principled set of interactions and eliminates artifacts from single experiments.

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