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ntolley committed Sep 23, 2023
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HNN-core is a library for circuit and cellular level interpretation of non-invasive human magneto-/electro-encephalography (MEG/EEG) data. It is based on the Human Neocortical Neurosolver (HNN) software [@neymotin2020human], a modeling tool designed to simulate multiscale neural mechanisms generating current dipoles in a localized patch of neocortex. HNN’s foundation is a biophysically detailed neural network representing a canonical neocortical column containing populations of pyramidal and inhibitory neurons together with layer-specific exogenous synaptic drive. In addition to simulating network-level interactions, HNN produces the intracellular currents in the long apical dendrites of pyramidal cells across the cortical layers known to be responsible for macroscopic current dipole generation.

HNN-core reproduces the workflows and tutorials provided in the original HNN software to generate commonly observed MEG/EEG signals including evoked response potentials (ERPs), and alpha (8-10 Hz), beta (15-30 Hz), and gamma rhythms (30-80 Hz). HNN-core enables simultaneous calculation and visualization of macro- to micro-scale dynamics including MEG/EEG current dipoles, local field potential, laminar current-source density, and cell spiking and intrinsic dynamics. Importantly, HNN-core adopts modern open source development standards including a simplified installation procedure, unit tests, automatic documentation builds, code coverage, continuous integration, and contributing guidelines, supporting community development and long-term sustainability.
HNN-core reproduces the workflows and tutorials provided in the original HNN software to generate commonly observed MEG/EEG signals including evoked response potentials (ERPs) and alpha (8-10 Hz), beta (15-30 Hz), and gamma (30-80 Hz) rhythms. HNN-core enables simultaneous calculation and visualization of macro- to micro-scale dynamics including MEG/EEG current dipoles, local field potential, laminar current-source density, and cell spiking and intrinsic dynamics. Importantly, HNN-core adopts modern open source development standards including a simplified installation procedure, unit tests, automatic documentation builds, code coverage, continuous integration, and contributing guidelines, supporting community development and long-term sustainability.

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