【生信进阶之路】盘点生物信息大牛课题组EP22：Linghua Wang 【王凌华教授审核版】

docs/2024-05/_生信进阶之路_盘点生物信息大牛课题组EP22_Linghua_Wang__王凌华教授审核版_.md

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+---
+title: "【生信进阶之路】盘点生物信息大牛课题组EP22：Linghua Wang 【王凌华教授审核版】"
+date: 2024-05-28T10:47:24Z
+draft: ["false"]
+tags: [
+  "fetched",
+  "bioinforbricker"
+]
+categories: ["Acdemic"]
+---
+【生信进阶之路】盘点生物信息大牛课题组EP22：Linghua Wang 【王凌华教授审核版】 by bioinforbricker
+------
+<div><hr><p><span>上一期的大牛课题组<a target="_blank" href="http://mp.weixin.qq.com/s?__biz=MzU1MjE5MTQwMA==&amp;mid=2247488143&amp;idx=1&amp;sn=2ceb4f00f38cc96a99670c46fd07a978&amp;chksm=fb848648ccf30f5e37a201281d3f95f705a079f544e94aa53ec6c8a7189eefcdaafe00185a77&amp;scene=21#wechat_redirect" textvalue="【生信进阶之路】盘点生物信息大牛课题组EP22：Linghua Wang" linktype="text" imgurl="" imgdata="null" data-itemshowtype="0" tab="innerlink" data-linktype="2">【生信进阶之路】盘点生物信息大牛课题组EP22：Linghua Wang</a> 不仅浏览量破万而且还有幸被小编的学术偶像<strong>王凌华教授</strong>本人刷到了<strong>╰(*°▽°*)╯</strong>。然而由于小编自身水平有限，导致在上一期帖子中有部分内容描述不太准确，王老师也百忙之中抽时间为我们<span>仔细的</span>做了修正，在此感谢王老师的倾心奉献。因此，<span>这期</span>咱们单独出一期<strong>大牛课题组——王凌华教授审核版</strong>！</span></p><hr><p><span></span></p><p><span><span>亲爱的小伙伴，好久不见啦！本期我们将介绍大牛科学家</span></span><strong><span><span>Linghua Wang（王凌华）</span></span></strong><span><span>和她所在德克萨斯大学</span><span>MD Anderson Cancer Center的课题组。Dr. Wang 是MD Anderson Cancer Center 基因组医学系的终身副教授，负责领导计算生物学实验室。她在计算生物学、癌症基因组学和免疫信息学方面</span></span><span><span>具</span></span><span><span>有丰富的专业知识。她的团队通过利用</span></span><strong><span><span>最先进</span></span></strong><strong><span><span>的单细胞和空间多组学技术</span></span></strong><strong><span><span>及</span></span></strong><strong><span><span>细胞成像</span></span></strong><strong><span><span>技术</span></span></strong><span><span>，结合</span></span><span><span>开发和创新使用</span></span><span><span>最</span></span><span><span>前沿</span></span><span><span>的生物信息学工具</span></span><span><span>，</span></span><strong><span><span>专注于肿瘤生态系统的深度</span></span></strong><strong><span><span>剖</span></span></strong><strong><span><span>析</span></span></strong><span><span>，包括</span></span><span><span>在肿瘤的发生，进展，转移，治疗反应和耐药性发生过程中的癌细胞与肿瘤微环境</span></span><span><span>（</span><span>TME）</span></span><span><span>细胞和分子</span></span><span><span>的</span></span><span><span>异质性、表型可塑性、动</span></span><span><span>态</span></span><span><span>变化，</span></span><span><span>以及癌细胞与肿瘤微环境</span></span><span><span>细胞之间的相互作用</span></span><span><span>。</span></span></p><hr><section><span><span></span></span></section><p><img data-galleryid="" data-imgfileid="100004496" data-ratio="0.6231884057971014" data-s="300,640" data-src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dNic36o1BwdHg3FFcZ9zUIJQjcdp4k98aR6CbXvUbNp6vpYCwCoGQnSw/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="552" src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dNic36o1BwdHg3FFcZ9zUIJQjcdp4k98aR6CbXvUbNp6vpYCwCoGQnSw/640?wx_fmt=png&amp;from=appmsg"></p><hr><section><strong><span><span>1.</span></span></strong><strong><span><span><span>实验室简介</span></span></span></strong><span><p></p></span></section><section><span><span>王教授</span></span><span><span>的</span></span><span><span>实验室自</span> 2017 年</span><span><span>下半年</span></span><span><span>成立以来，</span></span><span><span>一直在不断发展</span></span><span><span>壮大</span></span><span><span>。如今，实验室拥</span></span><span><span>有</span></span><strong><span><span> 17 名成员</span></span></strong><span><span>（</span></span><span><span>包括</span></span><span><span>2名讲师，2名数据科学家，9名博</span></span><span><span>士</span></span><span><span>后</span></span><span><span>研究员</span></span><span><span>，</span></span><span><span>和</span></span><span><span>4名</span></span><span><span>博士</span></span><span><span>研究生）。王教授实验室</span></span><strong><span><span>成果丰硕</span></span></strong><span><span>(e.g., Nature 2020</span></span><span>, 2024</span><span><span>; Nature Medicine 2020, 2021</span></span><span>, 2023</span><span><span>; Cancer Discovery 2021, 2022a, 2022b</span></span><span>, 2024</span><span><span>; Cancer Cell 2022, 2023a</span></span><span>, 2023b</span><span><span>; </span></span><span>Cell Systems 2023a, 2023b; </span><span><span>Blood Cancer Discovery 2022; Molecular Cancer 2022 ; Lancet Oncology 2022; Journal of Clinical Oncology 2022; Gut 2019, 2020; Nature Communications 2021-2022, n=5; Science Translational Medicine 2019; Clinical Cancer Research 2019; Cell Reports 2018</span></span><span>a, 2018b</span><span>, </span><span><span>等。</span></span><span>O</span><span><span>ther studies with significant contributions from Wang Lab include Nature 2022; Science 2021, n=2; Cancer Cell 2020; Nature Medicine 2018; Cell 2017; Gut 2020, 2022, n=2, Molecular Cancer 2019, among many others ) 建立了真正的协作网络，</span></span><span><span>采用</span></span><span><span>协作性</span></span><span><span>团队</span></span><span><span>方法</span></span><span><span>来应对癌症</span></span><span><span>挑战</span></span><span><span>。该实验室得到了美国国家癌症研究所</span></span><span><span>、德克萨斯州癌症预防</span></span><span><span>与</span></span><span><span>研究所</span></span><span><span>、突破癌症</span></span><span><span>基金会、</span><span>Andy Sabin家族基金会、MD安德森癌症中心登月计划</span></span><span><span>及</span></span><span><span>其他多项合作</span></span><span><span>课题</span></span><span><span>的资助</span></span><span><span>，<strong>科研经费充足</strong></span></span><span><span>。</span></span><span><p></p></span></section><section><span><strong><span><span>2.主要研究方向</span></span></strong></span></section><p><strong><span><span>单细胞和空间多组学 |</span></span></strong><strong><span><span> 细胞</span></span></strong><strong><span><span>邻域的空间分析 |</span></span></strong><strong><span><span> </span></span></strong><strong><span><span>肿瘤异质性和癌细胞可塑性 |肿瘤演变 |</span></span></strong><strong><span><span> </span></span></strong><strong><span><span>肿瘤微环境 |</span></span></strong><strong><span><span> </span></span></strong><strong><span><span>肿瘤-免疫相互作用 |</span></span></strong><strong><span><span> </span></span></strong><strong><span><span>三级淋巴结构</span></span></strong></p><p><span><span>王</span></span><span><span>教授的实验室有</span></span><span><span>以下</span></span><span><span>几个重点</span></span><span><span>研究</span></span><span><span>领域：</span></span><span><p></p></span></p><p><span>       </span><strong><span> 1）</span><span><span>从癌前病变到</span></span><span><span>侵袭</span></span><span><span>性癌症的转变：</span></span><span><span></span></span></strong><span><span>实验室全面</span></span><span><span>解析</span></span><span><span>肿瘤发</span></span><span><span>生</span></span><span><span>和进展的细胞和分子轨迹，旨在开发分类器和风险预测模型，以更</span></span><span><span>精确</span></span><span><span>地对患者进行分层，并</span></span><span><span>发现</span></span><span><span>潜在的靶点以</span></span><span><span>开发有效</span></span><span><span>的</span></span><span><span>干预</span></span><span><span>策略</span></span><span><span>。</span></span><span><p></p></span></p><p><span>   </span><strong><span>     2）</span><span><span>从</span></span><span><span>局部肿瘤</span></span><span><span>到</span></span><span><span>转移</span></span><span><span>瘤</span></span><span><span>的演变：</span></span><span><span></span></span></strong><span><span>实验室</span></span><span><span>深入研究肿瘤</span></span><span><span>转移的细胞和分子基础，</span></span><span><span>旨在</span></span><span><span>理</span></span><span><span>解癌细胞与</span><span>TME的共同</span></span><span><span>演变过程</span></span><span><span>，以及癌细胞与</span></span><span><span>原发瘤</span></span><span><span>和转移</span></span><span><span>瘤</span></span><span><span>微环境中的各种免疫</span></span><span><span>细胞</span></span><span><span>和基质细胞之间的适应性相互作用。</span></span><span><p></p></span></p><p><strong><span><span><span>    </span><span>   </span></span></span></strong><strong><span><span><span> </span><span>3）</span>抗癌治疗的动态反应</span></span><span><span>及</span></span><span><span>治疗耐药</span></span><span><span>的</span></span><span><span>产生</span></span><span><span>：</span></span></strong><strong><span><span></span></span></strong><span><span>实验室</span></span><span><span>致力于</span></span><span><span>查明</span></span><span><span>决定</span></span><span><span>肿瘤对抗癌治疗反应的</span></span><span><span>癌细胞</span></span><span><span>的内在因素和</span></span><span><span>肿瘤</span></span><span><span>微环境因素，识别</span></span><span><span>关键</span></span><span><span>生物标志物并开发模型以</span></span><span><span>在治疗前</span></span><span><span>预测患者</span></span><span><span>反应，</span></span><span><span>发现</span></span><span><span>新的靶点以</span></span><span><span>开发有效</span></span><span><span>的</span></span><span><span>联合疗法</span></span><span><span>。</span></span></p><section><span><span>王</span></span><span><span>教授实验室应用创新的生物信息学方法来</span></span><strong><span><span>剖析肿瘤</span><span>“生态系统”</span></span></strong><span><span>，在单细胞分辨率和空间环境中深入剖析肿瘤细胞和肿瘤微环境的细胞以及肿瘤</span><span>-免疫-基质</span></span><span><span>互作</span></span><span><span>。他们的目标是</span></span><strong><span><span>利用大数据的潜力来对抗癌症</span></span></strong><span><span>，他们的</span></span><strong><span><span>首要目标是提高我们对早期肿瘤发生、疾病进展和治疗耐药性发展背后的细胞和分子</span></span></strong><strong><span><span>机制</span></span></strong><strong><span><span>的理解</span></span></strong><span><span>，并将</span></span><span><span>新发现转化为改</span></span><span><span>进</span></span><span><span>的患者护理。</span></span><span><p></p></span></section><p><span><span>具体而言，他们的转化兴趣在于：</span></span></p><ul><ul><ul><li><section><strong><span>早期肿瘤发</span></strong><strong><span>生</span></strong><strong><span>：</span></strong><span>确定</span><span>驱动</span><span>从前体疾病</span><span>到</span><span>肿瘤进展的最早事件;识别特征并开发模型，以早期预测疾病进展和</span><span>预后</span><span>，并确定治疗</span><span>靶</span><span>标，以制定有效的拦截策略</span><span>。</span></section></li><li><section><strong><span>治疗耐药性：</span></strong><span> 识别影响肿瘤对抗癌治疗反应的肿瘤细胞内在</span><span>因素</span><span>和微环境因素，识别特征并开发</span><span>预测</span><span>模型</span><span>，</span><span>以</span><span>在治疗前</span><span>预测</span><span>和评估</span><span>患者</span><span>反应，并确定</span><span>新</span><span>的治疗</span><span>靶点</span><span>，</span><span>以</span><span>开发</span><span>更</span><span>有效</span><span>的</span><span>联合疗法</span><span>。</span></section></li><li><section><strong><span>微小残留病 （MRD）：</span></strong><span>详细</span><span>刻画</span><span>癌细胞以及</span><span>所在的肿瘤微环境，包括那些</span><span>庇护耐药细胞的</span><span>特定</span><span>微环境；</span></section></li><li><section><strong><span>转移：</span></strong><span>研究转移的细胞和分子基础，</span><span>深入</span><span>了解癌细胞</span><span>与</span><span>各种</span><span>免疫</span><span>细胞</span><span>和基质细胞在</span><span>肿瘤</span><span>原发</span><span>和转移部位</span><span>不同局部微环境中的癌症进化、相互作用和适应</span><span>机制</span><span>。</span></section></li></ul></ul></ul><p><span><strong><span><span>3.代表作</span></span></strong></span></p><h1 align="justify"><span><strong><span>(1)Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance</span></strong></span></h1><p><img data-galleryid="" data-imgfileid="100004498" data-ratio="0.6252676659528907" data-s="300,640" data-src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dwrGMgBEj0N8iayqjqCicPejqe9eyko154pWrLiaKIHAPxZhEp1NfcFdXg/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="467" src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dwrGMgBEj0N8iayqjqCicPejqe9eyko154pWrLiaKIHAPxZhEp1NfcFdXg/640?wx_fmt=png&amp;from=appmsg"></p><h1 align="justify"><span><strong><span>(2)Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression</span></strong></span></h1><p><img data-galleryid="" data-imgfileid="100004499" data-ratio="0.8806818181818182" data-s="300,640" data-src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dQFNQcdia3bMXlfkJBb3Q6RibgqxI7UbGjBYEJRDK34LpqKGI0ZF7bticg/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="352" src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dQFNQcdia3bMXlfkJBb3Q6RibgqxI7UbGjBYEJRDK34LpqKGI0ZF7bticg/640?wx_fmt=png&amp;from=appmsg"></p><h1 align="justify"><span><strong><span>(3)</span></strong></span><strong><span>An atlas of epithelial cell states and plasticity in lung adenocarcinoma</span></strong></h1><section><img data-galleryid="" data-imgfileid="100004500" data-ratio="0.6427145708582834" data-s="300,640" data-src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dAwicZS6TibAwRLLw13BBic8ofSOzmjuG1Opmib6b1AIGy0kTfrCia2GbibnQ/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="501" src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dAwicZS6TibAwRLLw13BBic8ofSOzmjuG1Opmib6b1AIGy0kTfrCia2GbibnQ/640?wx_fmt=png&amp;from=appmsg"></section><h1><span><strong><span>(4)Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma</span></strong></span><strong><span><p></p></span></strong></h1><p><img data-galleryid="" data-imgfileid="100004501" data-ratio="0.8234165067178503" data-s="300,640" data-src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dtkg3DKF0oz8zjibMd6QtpUqKZE9OOZt3Bk1ozbKicfOyzL1wY2xRpx5A/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="521" src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dtkg3DKF0oz8zjibMd6QtpUqKZE9OOZt3Bk1ozbKicfOyzL1wY2xRpx5A/640?wx_fmt=png&amp;from=appmsg"></p><section><span><strong><span>(5)The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma</span></strong></span><strong><span><p></p></span></strong></section><section><img data-galleryid="" data-imgfileid="100004502" data-ratio="0.46842105263157896" data-s="300,640" data-src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dREejlQZkcQyibml9b22iasjj5sITNC5JncoeyPdXoKHpasEnyBNyAaIA/640?wx_fmt=png&amp;from=appmsg" data-type="png" data-w="570" src="https://mmbiz.qpic.cn/sz_mmbiz_png/xmkKgOfKaJAYDuYxNMY2MsKTyibUIT61dREejlQZkcQyibml9b22iasjj5sITNC5JncoeyPdXoKHpasEnyBNyAaIA/640?wx_fmt=png&amp;from=appmsg"></section><section><span><strong><span>4.写在最后</span></strong></span><strong><span><span><p></p></span></span></strong></section><section><span><span>回顾王凌华教授的学术生涯，2003年本科毕业于山东第一医科大学临床医学，2006年硕士毕业于中山大学医学院眼科学，2011年博士毕业于东京大学工学院基因组科学和癌症基因组学。</span>2012-2014年<span>，她在德克萨斯州休斯顿贝勒医学院分子和人类遗传系和基因组测序中心从事癌症基因组学博士后研究。两年后，她晋升为贝勒医学院讲师（</span>2014 - 2015 年<span>），随后晋升为贝勒医学院助教授（2</span>015 - 2017 年<span>）。</span> 2017<span>年，她在众多候选人中脱颖而出，被德克萨斯大学</span>MD安德森癌症中心癌症医学<span>部基因组医学系聘为终身教职的助教授，</span> <span>并于2</span>022 <span>年获得终身教职并晋升为副教授。其学术生涯在其实验室官网有着详细的介绍，看完不禁让人感慨王教授对科研持之以恒的热爱。相信在未来她的实验室一定会为我们的医学研究，特别是肿瘤领域的<span>研究</span>带来更多优质的成果。<strong>补充一句：</strong>王凌华教授实验室正在积极寻找<strong>博士后研究员</strong>、<strong>计算科学家</strong>和<strong>博士研究生</strong>。如果你对她的研究方向感兴趣，可以访问官网(Linghua Wang | MD Anderson Cancer Center)了解更详细的信息，</span> <span>或邮件联系王教授：</span></span><strong><span>[email protected]</span></strong><span><span>。</span></span></section><p><mp-style-type data-value="3"></mp-style-type></p></div>  
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+<a href="https://mp.weixin.qq.com/s/WDVxiWVJ4F7ZS1pLOJ2qWQ",target="_blank" rel="noopener noreferrer">原文链接</a>