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Uses same code for source code generation in modules (#1301)
Part of insightsengineering/teal#1371 ### Example app with all modules / decorators <details> <summary>Example app</summary> ```r # Load packages pkgload::load_all("../teal.modules.clinical", export_all = FALSE) # Decorators ------------------------------------------------------------------ insert_rrow_decorator <- function(default_caption = "I am a good new row", .var_to_replace = "table") { teal_transform_module( label = "New rtables row", ui = function(id) shiny::textInput(shiny::NS(id, "new_row"), "New row", value = default_caption), server = make_teal_transform_server( substitute({ .var_to_replace <- rtables::insert_rrow(.var_to_replace, rtables::rrow(new_row)) }, env = list(.var_to_replace = as.name(.var_to_replace))) ) ) } add_title_decorator <- function(default_check = TRUE, .var_to_replace = "plot") { teal_transform_module( label = "Title", ui = function(id) shiny::checkboxInput(NS(id, "flag"), "Add title?", TRUE), server = make_teal_transform_server( substitute({ if (flag) .var_to_replace <- .var_to_replace + ggplot2::ggtitle("Title added by decorator") }, env = list(.var_to_replace = as.name(.var_to_replace)) ) ) ) } caption_decorator <- function(default_caption = "I am a good decorator", .var_to_replace = "plot") { teal_transform_module( label = "Caption", ui = function(id) shiny::textInput(shiny::NS(id, "footnote"), "Footnote", value = default_caption), server = make_teal_transform_server( substitute({ .var_to_replace <- .var_to_replace + ggplot2::labs(caption = footnote) }, env = list(.var_to_replace = as.name(.var_to_replace))) ) ) } change_theme_decorator <- function(default_check = TRUE, .var_to_replace = "plot") { teal_transform_module( label = "Theme", ui = function(id) shiny::checkboxInput(NS(id, "flag"), "Apply dark theme?", TRUE), server = make_teal_transform_server( substitute({ if (flag) .var_to_replace <- .var_to_replace + ggplot2::theme_dark() }, env = list(.var_to_replace = as.name(.var_to_replace)) ) ) ) } add_cowplot_title_decorator <- function(default_check = TRUE, .var_to_replace = "plot") { teal_transform_module( label = "Cowplot title", ui = function(id) shiny::checkboxInput(NS(id, "flag"), "Add title?", TRUE), server = make_teal_transform_server( substitute({ if (flag) .var_to_replace <- .var_to_replace + ggplot2::ggtitle("Title added by decorator") + cowplot::theme_cowplot() }, env = list(.var_to_replace = as.name(.var_to_replace)) ) ) ) } rlisting_footer <- function(default_footer = "I am a good footer", .var_to_replace = "table_listing") { teal_transform_module( label = "New row", ui = function(id) shiny::textInput(shiny::NS(id, "footer"), "footer", value = default_footer), server = make_teal_transform_server( substitute({ rlistings::main_footer(.var_to_replace) <- footer }, env = list(.var_to_replace = as.name(.var_to_replace))) ) ) } # End of decorators ----------------------------------------------------------- library(dplyr) # arm_ref_comp <- list(ARMCD = list(ref = "ARM B", comp = c("ARM A", "ARM C"))) arm_ref_comp <- list( ACTARMCD = list(ref = "ARM B", comp = c("ARM A", "ARM C")), ARM = list(ref = "B: Placebo", comp = c("A: Drug X", "C: Combination")) ) data <- within(teal_data(), { ADSL <- tmc_ex_adsl |> mutate(ITTFL = factor("Y") |> with_label("Intent-To-Treat Population Flag")) |> mutate(DTHFL = case_when(!is.na(DTHDT) ~ "Y", TRUE ~ "") |> with_label("Subject Death Flag")) ADAE <- tmc_ex_adae |> filter(!((AETOXGR == 1) & (AESEV == "MILD") & (ARM == "A: Drug X"))) ADAE$ASTDY <- structure( as.double(ADAE$ASTDY, unit = attr(ADAE$ASTDY, "units", exact = TRUE)), label = attr(ADAE$ASTDY, "label", exact = TRUE) ) .lbls_adae <- col_labels(tmc_ex_adae) ADAE <- tmc_ex_adae %>% mutate_if(is.character, as.factor) #' be certain of having factors col_labels(ADAE) <- .lbls_adae ADTTE <- tmc_ex_adtte ADLB <- tmc_ex_adlb |> mutate(AVISIT == forcats::fct_reorder(AVISIT, AVISITN, min)) |> mutate( ONTRTFL = case_when( AVISIT %in% c("SCREENING", "BASELINE") ~ "", TRUE ~ "Y" ) |> with_label("On Treatment Record Flag") ) ADVS <- tmc_ex_advs ADRS <- tmc_ex_adrs |> mutate( AVALC = d_onco_rsp_label(AVALC) |> with_label("Character Result/Finding") ) |> filter(PARAMCD != "OVRINV" | AVISIT == "FOLLOW UP") |> filter(PARAMCD %in% c("BESRSPI", "INVET")) ADAETTE <- tmc_ex_adaette %>% filter(PARAMCD %in% c("AETTE1", "AETTE2", "AETTE3")) %>% mutate(is_event = CNSR == 0) %>% mutate(n_events = as.integer(is_event)) .add_event_flags <- function(dat) { dat <- dat %>% mutate( TMPFL_SER = AESER == "Y", TMPFL_REL = AEREL == "Y", TMPFL_GR5 = AETOXGR == "5", TMP_SMQ01 = !is.na(SMQ01NAM), TMP_SMQ02 = !is.na(SMQ02NAM), TMP_CQ01 = !is.na(CQ01NAM) ) column_labels <- list( TMPFL_SER = "Serious AE", TMPFL_REL = "Related AE", TMPFL_GR5 = "Grade 5 AE", TMP_SMQ01 = aesi_label(dat[["SMQ01NAM"]], dat[["SMQ01SC"]]), TMP_SMQ02 = aesi_label("Y.9.9.9.9/Z.9.9.9.9 AESI"), TMP_CQ01 = aesi_label(dat[["CQ01NAM"]]) ) col_labels(dat)[names(column_labels)] <- as.character(column_labels) dat } ADEX <- tmc_ex_adex set.seed(1, kind = "Mersenne-Twister") .labels <- col_labels(ADEX, fill = FALSE) ADEX <- ADEX %>% distinct(USUBJID, .keep_all = TRUE) %>% mutate( PARAMCD = "TDURD", PARAM = "Overall duration (days)", AVAL = sample(x = seq(1, 200), size = n(), replace = TRUE), AVALU = "Days" ) %>% bind_rows(ADEX) col_labels(ADEX) <- .labels ADCM <- tmc_ex_adcm ADMH <- tmc_ex_admh ADCM$CMASTDTM <- ADCM$ASTDTM ADCM$CMAENDTM <- ADCM$AENDTM ADEG <- tmc_ex_adeg # smq .names_baskets <- grep("^(SMQ|CQ).*NAM$", names(ADAE), value = TRUE) .names_scopes <- grep("^SMQ.*SC$", names(ADAE), value = TRUE) .cs_baskets <- choices_selected( choices = variable_choices(ADAE, subset = .names_baskets), selected = .names_baskets ) .cs_scopes <- choices_selected( choices = variable_choices(ADAE, subset = .names_scopes), selected = .names_scopes, fixed = TRUE ) # summary ADSL$EOSDY[1] <- NA_integer_ }) join_keys(data) <- default_cdisc_join_keys[names(data)] adcm_keys <- c("STUDYID", "USUBJID", "ASTDTM", "CMSEQ", "ATC1", "ATC2", "ATC3", "ATC4") join_keys(data)["ADCM", "ADCM"] <- adcm_keys # Use in choices selected ----------------------------------------------------- ADSL <- data[["ADSL"]] ADQS <- data[["ADQS"]] ADAE <- data[["ADAE"]] ADTTE <- data[["ADTTE"]] ADLB <- data[["ADLB"]] ADAE <- data[["ADAE"]] ADVS <- data[["ADVS"]] ADRS <- data[["ADRS"]] ADAETTE <- data[["ADAETTE"]] ADEX <- data[["ADEX"]] ADCM <- data[["ADCM"]] ADMH <- data[["ADMH"]] ADEG <- data[["ADEG"]] # Init ------------------------------------------------------------------------ init( data = data, modules = modules( # ------------------------------------------------------------------------- tm_t_summary_by( label = "Summary by Row Groups Table", dataname = "ADLB", arm_var = choices_selected( choices = variable_choices(ADSL, c("ARM", "ARMCD")), selected = "ARM" ), add_total = TRUE, by_vars = choices_selected( choices = variable_choices(ADLB, c("PARAM", "AVISIT")), selected = c("AVISIT") ), summarize_vars = choices_selected( choices = variable_choices(ADLB, c("AVAL", "CHG")), selected = c("AVAL") ), useNA = "ifany", paramcd = choices_selected( choices = value_choices(ADLB, "PARAMCD", "PARAM"), selected = "ALT" ), decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_smq( label = "Adverse Events by SMQ Table", dataname = "ADAE", arm_var = choices_selected( choices = variable_choices(data[["ADSL"]], subset = c("ARM", "SEX")), selected = "ARM" ), add_total = FALSE, baskets = data[[".cs_baskets"]], scopes = data[[".cs_scopes"]], llt = choices_selected( choices = variable_choices(data[["ADAE"]], subset = c("AEDECOD")), selected = "AEDECOD" ), decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_shift_by_grade( label = "Grade Laboratory Abnormality Table", dataname = "ADLB", arm_var = choices_selected( choices = variable_choices(ADSL, subset = c("ARM", "ARMCD")), selected = "ARM" ), paramcd = choices_selected( choices = value_choices(ADLB, "PARAMCD", "PARAM"), selected = "ALT" ), worst_flag_var = choices_selected( choices = variable_choices(ADLB, subset = c("WGRLOVFL", "WGRLOFL", "WGRHIVFL", "WGRHIFL")), selected = c("WGRLOVFL") ), worst_flag_indicator = choices_selected( value_choices(ADLB, "WGRLOVFL"), selected = "Y", fixed = TRUE ), anl_toxgrade_var = choices_selected( choices = variable_choices(ADLB, subset = c("ATOXGR")), selected = c("ATOXGR"), fixed = TRUE ), base_toxgrade_var = choices_selected( choices = variable_choices(ADLB, subset = c("BTOXGR")), selected = c("BTOXGR"), fixed = TRUE ), add_total = FALSE, decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_shift_by_arm( label = "Shift by Arm Table", dataname = "ADEG", arm_var = choices_selected( variable_choices(ADSL, subset = c("ARM", "ARMCD")), selected = "ARM" ), paramcd = choices_selected( value_choices(ADEG, "PARAMCD"), selected = "HR" ), visit_var = choices_selected( value_choices(ADEG, "AVISIT"), selected = "POST-BASELINE MINIMUM" ), aval_var = choices_selected( variable_choices(ADEG, subset = "ANRIND"), selected = "ANRIND", fixed = TRUE ), baseline_var = choices_selected( variable_choices(ADEG, subset = "BNRIND"), selected = "BNRIND", fixed = TRUE ), useNA = "ifany", decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_shift_by_arm_by_worst( label = "Shift by Arm Table (by worst)", dataname = "ADEG", arm_var = choices_selected( variable_choices(ADSL, subset = c("ARM", "ARMCD")), selected = "ARM" ), paramcd = choices_selected( value_choices(ADEG, "PARAMCD"), selected = "ECGINTP" ), worst_flag_var = choices_selected( variable_choices(ADEG, c("WORS02FL", "WORS01FL")), selected = "WORS02FL" ), worst_flag = choices_selected( value_choices(ADEG, "WORS02FL"), selected = "Y", fixed = TRUE ), aval_var = choices_selected( variable_choices(ADEG, c("AVALC", "ANRIND")), selected = "AVALC" ), baseline_var = choices_selected( variable_choices(ADEG, c("BASEC", "BNRIND")), selected = "BASEC" ), useNA = "ifany", decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_pp_prior_medication( label = "Prior Medication", dataname = "ADCM", parentname = "ADSL", patient_col = "USUBJID", atirel = choices_selected( choices = variable_choices(ADCM, "ATIREL"), selected = "ATIREL" ), cmdecod = choices_selected( choices = variable_choices(ADCM, "CMDECOD"), selected = "CMDECOD" ), cmindc = choices_selected( choices = variable_choices(ADCM, "CMINDC"), selected = "CMINDC" ), cmstdy = choices_selected( choices = variable_choices(ADCM, "ASTDY"), selected = "ASTDY" ), decorators = list( table = rlisting_footer(.var_to_replace = "table") ) ), # ------------------------------------------------------------------------- tm_t_pp_medical_history( label = "Medical History", dataname = "ADMH", parentname = "ADSL", patient_col = "USUBJID", mhterm = choices_selected( choices = variable_choices(ADMH, c("MHTERM")), selected = "MHTERM" ), mhbodsys = choices_selected( choices = variable_choices(ADMH, "MHBODSYS"), selected = "MHBODSYS" ), mhdistat = choices_selected( choices = variable_choices(ADMH, "MHDISTAT"), selected = "MHDISTAT" ), decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_pp_laboratory( label = "Vitals", dataname = "ADLB", patient_col = "USUBJID", paramcd = choices_selected( choices = variable_choices(ADLB, "PARAMCD"), selected = "PARAMCD" ), param = choices_selected( choices = variable_choices(ADLB, "PARAM"), selected = "PARAM" ), timepoints = choices_selected( choices = variable_choices(ADLB, "ADY"), selected = "ADY" ), anrind = choices_selected( choices = variable_choices(ADLB, "ANRIND"), selected = "ANRIND" ), aval_var = choices_selected( choices = variable_choices(ADLB, "AVAL"), selected = "AVAL" ), avalu_var = choices_selected( choices = variable_choices(ADLB, "AVALU"), selected = "AVALU" ), decorators = list(table = rlisting_footer(.var_to_replace = "table")) ), # ------------------------------------------------------------------------- tm_t_pp_basic_info( label = "Basic Info", dataname = "ADSL", patient_col = "USUBJID", vars = choices_selected(choices = variable_choices(ADSL), selected = c("ARM", "AGE", "SEX", "COUNTRY", "RACE", "EOSSTT")) , decorators = list( table = rlisting_footer(.var_to_replace = "table") ) ), # ------------------------------------------------------------------------- tm_t_mult_events( label = "Concomitant Medications by Medication Class and Preferred Name", dataname = "ADCM", arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"), seq_var = choices_selected("CMSEQ", selected = "CMSEQ", fixed = TRUE), hlt = choices_selected( choices = variable_choices(ADCM, c("ATC1", "ATC2", "ATC3", "ATC4")), selected = c("ATC1", "ATC2", "ATC3", "ATC4") ), llt = choices_selected(choices = variable_choices(ADCM, c("CMDECOD")), selected = c("CMDECOD")), add_total = TRUE, event_type = "treatment", decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_logistic( label = "Logistic Regression", dataname = "ADRS", arm_var = choices_selected( choices = variable_choices(ADRS, c("ARM", "ARMCD")), selected = "ARM" ), arm_ref_comp = arm_ref_comp, paramcd = choices_selected( choices = value_choices(ADRS, "PARAMCD", "PARAM"), selected = "BESRSPI" ), cov_var = choices_selected( choices = c("SEX", "AGE", "BMRKR1", "BMRKR2"), selected = "SEX" ), decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_exposure( label = "Duration of Exposure Table", dataname = "ADEX", paramcd = choices_selected( choices = value_choices(data[["ADEX"]], "PARAMCD", "PARAM"), selected = "TDURD" ), col_by_var = choices_selected( choices = variable_choices(data[["ADEX"]], subset = c("SEX", "ARM")), selected = "SEX" ), row_by_var = choices_selected( choices = variable_choices(data[["ADEX"]], subset = c("RACE", "REGION1", "STRATA1", "SEX")), selected = "RACE" ), parcat = choices_selected( choices = value_choices(data[["ADEX"]], "PARCAT2"), selected = "Drug A" ), add_total = FALSE, decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_events( label = "Adverse Event Table", dataname = "ADAE", arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"), llt = choices_selected( choices = variable_choices(ADAE, c("AETERM", "AEDECOD")), selected = c("AEDECOD") ), hlt = choices_selected( choices = variable_choices(ADAE, c("AEBODSYS", "AESOC")), selected = "AEBODSYS" ), add_total = TRUE, event_type = "adverse event", decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_events_patyear( label = "AE Rate Adjusted for Patient-Years At Risk Table", dataname = "ADAETTE", arm_var = choices_selected( choices = variable_choices(ADSL, c("ARM", "ARMCD")), selected = "ARMCD" ), add_total = TRUE, events_var = choices_selected( choices = variable_choices(ADAETTE, "n_events"), selected = "n_events", fixed = TRUE ), paramcd = choices_selected( choices = value_choices(ADAETTE, "PARAMCD", "PARAM"), selected = "AETTE1" ), decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_events_by_grade( label = "Adverse Events by Grade Table", dataname = "ADAE", arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"), llt = choices_selected( choices = variable_choices(ADAE, c("AETERM", "AEDECOD")), selected = c("AEDECOD") ), hlt = choices_selected( choices = variable_choices(ADAE, c("AEBODSYS", "AESOC")), selected = "AEBODSYS" ), grade = choices_selected( choices = variable_choices(ADAE, c("AETOXGR", "AESEV")), selected = "AETOXGR" ), decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_coxreg( label = "Cox Reg.", dataname = "ADTTE", arm_var = choices_selected(c("ARM", "ARMCD", "ACTARMCD"), "ARM"), arm_ref_comp = arm_ref_comp, paramcd = choices_selected( value_choices(ADTTE, "PARAMCD", "PARAM"), "OS" ), strata_var = choices_selected( c("COUNTRY", "STRATA1", "STRATA2"), "STRATA1" ), cov_var = choices_selected( c("AGE", "BMRKR1", "BMRKR2", "REGION1"), "AGE" ), multivariate = TRUE, decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_abnormality( label = "Abnormality Table", dataname = "ADLB", arm_var = choices_selected( choices = variable_choices(ADSL, subset = c("ARM", "ARMCD")), selected = "ARM" ), add_total = FALSE, by_vars = choices_selected( choices = variable_choices(ADLB, subset = c("LBCAT", "PARAM", "AVISIT")), selected = c("LBCAT", "PARAM"), keep_order = TRUE ), baseline_var = choices_selected( variable_choices(ADLB, subset = "BNRIND"), selected = "BNRIND", fixed = TRUE ), grade = choices_selected( choices = variable_choices(ADLB, subset = "ANRIND"), selected = "ANRIND", fixed = TRUE ), abnormal = list(low = "LOW", high = "HIGH"), exclude_base_abn = FALSE, decorators = list(insert_rrow_decorator("I am a good new row")) ), # ------------------------------------------------------------------------- tm_g_pp_vitals( label = "Vitals", dataname = "ADVS", parentname = "ADSL", patient_col = "USUBJID", plot_height = c(600L, 200L, 2000L), paramcd = choices_selected( choices = variable_choices(ADVS, "PARAMCD"), selected = "PARAMCD" ), xaxis = choices_selected( choices = variable_choices(ADVS, "ADY"), selected = "ADY" ), aval_var = choices_selected( choices = variable_choices(ADVS, "AVAL"), selected = "AVAL" ), decorators = list(plot = add_title_decorator("plot")) ), # ------------------------------------------------------------------------- tm_g_pp_adverse_events( label = "Adverse Events", dataname = "ADAE", parentname = "ADSL", patient_col = "USUBJID", plot_height = c(600L, 200L, 2000L), aeterm = choices_selected( choices = variable_choices(ADAE, "AETERM"), selected = "AETERM" ), tox_grade = choices_selected( choices = variable_choices(ADAE, "AETOXGR"), selected = "AETOXGR" ), causality = choices_selected( choices = variable_choices(ADAE, "AEREL"), selected = "AEREL" ), outcome = choices_selected( choices = variable_choices(ADAE, "AEOUT"), selected = "AEOUT" ), action = choices_selected( choices = variable_choices(ADAE, "AEACN"), selected = "AEACN" ), time = choices_selected( choices = variable_choices(ADAE, "ASTDY"), selected = "ASTDY" ), decod = NULL, decorators = list( plot = caption_decorator('I am a good caption', 'plot'), table = rlisting_footer(.var_to_replace = 'table') ) ), # ------------------------------------------------------------------------- tm_g_lineplot( label = "Line Plot", dataname = "ADLB", strata = choices_selected( variable_choices(ADSL, c("ARM", "ARMCD", "ACTARMCD")), "ARM" ), y = choices_selected( variable_choices(ADLB, c("AVAL", "BASE", "CHG", "PCHG")), "AVAL" ), param = choices_selected( value_choices(ADLB, "PARAMCD", "PARAM"), "ALT" ), decorators = list(add_cowplot_title_decorator("plot")) ), # ------------------------------------------------------------------------- tm_g_km( label = "Kaplan-Meier Plot", dataname = "ADTTE", arm_var = choices_selected( variable_choices(ADSL, c("ARM", "ARMCD", "ACTARMCD")), "ARM" ), paramcd = choices_selected( value_choices(ADTTE, "PARAMCD", "PARAM"), "OS" ), arm_ref_comp = arm_ref_comp, strata_var = choices_selected( variable_choices(ADSL, c("SEX", "BMRKR2")), "SEX" ), facet_var = choices_selected( variable_choices(ADSL, c("SEX", "BMRKR2")), NULL ), decorators = list(plot = add_cowplot_title_decorator(TRUE, "plot")) ), # ------------------------------------------------------------------------- tm_g_barchart_simple( label = "ADAE Analysis", x = data_extract_spec( dataname = "ADSL", select = select_spec( choices = variable_choices( ADSL, c( "ARM", "ACTARM", "SEX", "RACE", "ITTFL", "SAFFL", "STRATA2" ) ), selected = "ACTARM", multiple = FALSE ) ), fill = list( data_extract_spec( dataname = "ADSL", select = select_spec( choices = variable_choices( ADSL, c( "ARM", "ACTARM", "SEX", "RACE", "ITTFL", "SAFFL", "STRATA2" ) ), selected = "SEX", multiple = FALSE ) ), data_extract_spec( dataname = "ADAE", select = select_spec( choices = variable_choices(ADAE, c("AETOXGR", "AESEV", "AESER")), selected = NULL, multiple = FALSE ) ) ), x_facet = list( data_extract_spec( dataname = "ADAE", select = select_spec( choices = variable_choices(ADAE, c("AETOXGR", "AESEV", "AESER")), selected = "AETOXGR", multiple = FALSE ) ), data_extract_spec( dataname = "ADSL", select = select_spec( choices = variable_choices( ADSL, c( "ARM", "ACTARM", "SEX", "RACE", "ITTFL", "SAFFL", "STRATA2" ) ), selected = NULL, multiple = FALSE ) ) ), y_facet = list( data_extract_spec( dataname = "ADAE", select = select_spec( choices = variable_choices(ADAE, c("AETOXGR", "AESEV", "AESER")), selected = "AESEV", multiple = FALSE ) ), data_extract_spec( dataname = "ADSL", select = select_spec( choices = variable_choices( ADSL, c( "ARM", "ACTARM", "SEX", "RACE", "ITTFL", "SAFFL", "STRATA2" ) ), selected = NULL, multiple = FALSE ) ) ), decorators = list(plot = caption_decorator('The best', 'plot')) ) ) ) |> shiny::runApp() ``` </details> <details> <summary>Second App</summary> ```r # Load packages pkgload::load_all("../teal.modules.clinical", export_all = FALSE) # Example below insert_rrow_decorator <- function(default_caption = "I am a good new row", .var_to_replace = "table") { teal_transform_module( label = "New row", ui = function(id) shiny::textInput(shiny::NS(id, "new_row"), "New row", value = default_caption), server = make_teal_transform_server( substitute({ .var_to_replace <- rtables::insert_rrow(.var_to_replace, rtables::rrow(new_row)) }, env = list(.var_to_replace = as.name(.var_to_replace))) ) ) } # Preparation of the test case - use `EOSDY` and `DCSREAS` variables to demonstrate missing data. data <- teal_data() data <- within(data, { ADSL <- tmc_ex_adsl |> mutate( DTHFL = case_when( !is.na(DTHDT) ~ "Y", TRUE ~ "" ) %>% with_label("Subject Death Flag") ) ADSL$EOSDY[1] <- NA_integer_ ADAE <- tmc_ex_adae .add_event_flags <- function(dat) { dat <- dat %>% mutate( TMPFL_SER = AESER == "Y", TMPFL_REL = AEREL == "Y", TMPFL_GR5 = AETOXGR == "5", TMP_SMQ01 = !is.na(SMQ01NAM), TMP_SMQ02 = !is.na(SMQ02NAM), TMP_CQ01 = !is.na(CQ01NAM) ) column_labels <- list( TMPFL_SER = "Serious AE", TMPFL_REL = "Related AE", TMPFL_GR5 = "Grade 5 AE", TMP_SMQ01 = aesi_label(dat[["SMQ01NAM"]], dat[["SMQ01SC"]]), TMP_SMQ02 = aesi_label("Y.9.9.9.9/Z.9.9.9.9 AESI"), TMP_CQ01 = aesi_label(dat[["CQ01NAM"]]) ) col_labels(dat)[names(column_labels)] <- as.character(column_labels) dat } #' Generating user-defined event flags. ADAE <- ADAE %>% .add_event_flags() .ae_anl_vars <- names(ADAE)[startsWith(names(ADAE), "TMPFL_")] .aesi_vars <- names(ADAE)[startsWith(names(ADAE), "TMP_")] ADTTE <- tmc_ex_adtte # responder ADRS <- tmc_ex_adrs %>% mutate( AVALC = d_onco_rsp_label(AVALC) %>% with_label("Character Result/Finding") ) %>% filter(PARAMCD != "OVRINV" | AVISIT == "FOLLOW UP") ADQS <- tmc_ex_adqs %>% filter(ABLFL != "Y" & ABLFL2 != "Y") %>% filter(AVISIT %in% c("WEEK 1 DAY 8", "WEEK 2 DAY 15", "WEEK 3 DAY 22")) %>% mutate( AVISIT = as.factor(AVISIT), AVISITN = rank(AVISITN) %>% as.factor() %>% as.numeric() %>% as.factor() #' making consecutive numeric factor ) }) join_keys(data) <- default_cdisc_join_keys[names(data)] ADSL <- data[["ADSL"]] ADRS <- data[["ADRS"]] app <- init( data = data, modules = modules( # ------------------------------------------------------------------------- tm_a_mmrm( label = "MMRM", dataname = "ADQS", aval_var = choices_selected(c("AVAL", "CHG"), "AVAL"), id_var = choices_selected(c("USUBJID", "SUBJID"), "USUBJID"), arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"), visit_var = choices_selected(c("AVISIT", "AVISITN"), "AVISIT"), arm_ref_comp = arm_ref_comp, paramcd = choices_selected( choices = value_choices(data[["ADQS"]], "PARAMCD", "PARAM"), selected = "FKSI-FWB" ), cov_var = choices_selected(c("BASE", "AGE", "SEX", "BASE:AVISIT"), NULL) , decorators = list( lsmeans_table = insert_rrow_decorator("A", .var_to_replace = "lsmeans_table") , lsmeans_plot = add_title_decorator("B", .var_to_replace = "lsmeans_plot") , covariance_table = insert_rrow_decorator("C", .var_to_replace = "covariance_table") , fixed_effects_table = insert_rrow_decorator("D", .var_to_replace = "fixed_effects_table") , diagnostic_table = insert_rrow_decorator(.var_to_replace = "diagnostic_table") , diagnostic_plot = add_title_decorator(.var_to_replace = "diagnostic_plot") ) ), # ------------------------------------------------------------------------- tm_t_binary_outcome( label = "Responders", dataname = "ADRS", paramcd = choices_selected( choices = value_choices(ADRS, "PARAMCD", "PARAM"), selected = "BESRSPI" ), arm_var = choices_selected( choices = variable_choices(ADRS, c("ARM", "ARMCD", "ACTARMCD")), selected = "ARM" ), arm_ref_comp = arm_ref_comp, strata_var = choices_selected( choices = variable_choices(ADRS, c("SEX", "BMRKR2", "RACE")), selected = "RACE" ), default_responses = list( BESRSPI = list( rsp = c("Complete Response (CR)", "Partial Response (PR)"), levels = c( "Complete Response (CR)", "Partial Response (PR)", "Stable Disease (SD)", "Progressive Disease (PD)" ) ), INVET = list( rsp = c("Stable Disease (SD)", "Not Evaluable (NE)"), levels = c( "Complete Response (CR)", "Not Evaluable (NE)", "Partial Response (PR)", "Progressive Disease (PD)", "Stable Disease (SD)" ) ), OVRINV = list( rsp = c("Progressive Disease (PD)", "Stable Disease (SD)"), levels = c("Progressive Disease (PD)", "Stable Disease (SD)", "Not Evaluable (NE)") ) ), decorators = list(insert_rrow_decorator("I am a new row")) ), # ------------------------------------------------------------------------- tm_t_events_summary( label = "Adverse Events Summary", dataname = "ADAE", arm_var = choices_selected( choices = variable_choices("ADSL", c("ARM", "ARMCD")), selected = "ARM" ), flag_var_anl = choices_selected( choices = variable_choices("ADAE", data[[".ae_anl_vars"]]), selected = data[[".ae_anl_vars"]][1], keep_order = TRUE, fixed = FALSE ), flag_var_aesi = choices_selected( choices = variable_choices("ADAE", data[[".aesi_vars"]]), selected = data[[".aesi_vars"]][1], keep_order = TRUE, fixed = FALSE ), add_total = TRUE, decorators = list(insert_rrow_decorator()) ), # ------------------------------------------------------------------------- tm_t_summary( label = "Demographic Table", dataname = "ADSL", arm_var = choices_selected(c("ARM", "ARMCD"), "ARM"), add_total = TRUE, summarize_vars = choices_selected( c("SEX", "RACE", "BMRKR2", "EOSDY", "DCSREAS", "AGE"), c("SEX", "RACE") ), useNA = "ifany", decorators = list(insert_rrow_decorator()) ) ) ) |> shiny::runApp() ``` </details>
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