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This is a repository for Suboptimization of human transcription factors 2024

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An activity-specificity trade-off encoded in human transcription factors 2024

This is a repository for Naderi & Magalhaes et al.

DOI: 10.1038/s41556-024-01411-0

The main bioinformatics analysis is listed by figure The main scripts for scRNAseq are listed as separate folders

A copy of the main scRNAseq object is located in Zendo link:

A copy of the Periodic finder and QuasiIDR finder are stored also: Links:

https://github.com/alexpmagalhaes/PeriodicBlock_finder

https://github.com/gozdekibar/QuasiIDRFinder

Questions regarding code please email:

Alexandre P Magalhaes -> [email protected] or to github: @alexpmagalhaes

R packages needed:

tidyverse, ggthemes, ggpubr, bbplot, circlize, MASS, viridis, cowplot, RColorBrewer, ggrepel, readxl, drawProteins, Biostrings, universalmotif, DESeq2, ComplexHeatmap, dendextend, biomaRt, SARTools, pheatmap, pcaExplorer, topGO, org.Hs.eg.db, tidyverse, cluster, factoextra, NbClust, Seurat, hdf5r, kableExtra, limma, sva, scran, DoubletFinder, gprofiler2, rliger, future, harmony, clustree, venn, enrichR, rafalib, scPred, loomR, SeuratWrappers, velocyto.R, Nebulosa, ggalluvial, patchwork, EnvStats, RcppCNPy, DescTools, rison, seqinr, protr, jsonlite, DOSE, GSEABase

Python packages needed:

velocyto, alphafold, metapredict, pandas, matplotlib, localcider, coolbox, scanpy, anndata, numpy, cellrank , scvelo, igraph, Biopython

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