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Fixes for some steroid terms #29311

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8 tasks done
pgaudet opened this issue Nov 27, 2024 · 5 comments
Open
8 tasks done

Fixes for some steroid terms #29311

pgaudet opened this issue Nov 27, 2024 · 5 comments

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@pgaudet
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pgaudet commented Nov 27, 2024

Fixed parents:

  • 3beta-hydroxy-5beta-steroid dehydrogenase activity: add parent: is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
  • 3beta-hydroxy-5alpha-steroid dehydrogenase activity: add parent: is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
  • sterol desaturase activity: change parent:
  • from: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
  • to GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

Added missing xrefs:

@pgaudet
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pgaudet commented Nov 27, 2024

PR: #29306

@pgaudet pgaudet closed this as completed Nov 27, 2024
pgaudet added a commit that referenced this issue Nov 27, 2024
@pgaudet pgaudet changed the title Fix parents for some steroid terms Fixes for some steroid terms Nov 27, 2024
@pgaudet pgaudet reopened this Nov 27, 2024
@github-project-automation github-project-automation bot moved this from Done to In progress in GO-EC-RHEA xref alignment Nov 27, 2024
@pgaudet
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pgaudet commented Nov 27, 2024

  • GO:0047024 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity: add parent GO:0008395 ! steroid hydroxylase activity
  • GO:0050212 'progesterone 11-alpha-monooxygenase activity' add parent GO:0050214 ! progesterone monooxygenase activity
  • GO:0000253 3-keto sterol reductase activity: change label to 3-beta-hydroxysteroid 3-dehydrogenase activity to match EC; add parent GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
  • GO:0062179 vitamin D 23-hydroxylase activity: add parent: GO:0008395 ! steroid hydroxylase activity
  • vitamin D 24-hydroxylase activity: add parent: GO:0008395 ! steroid hydroxylase activity
  • vitamin D 25-hydroxylase activity : add parent: GO:0008395 ! steroid hydroxylase activity

@pgaudet
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pgaudet commented Nov 27, 2024

  • 'steroid hydroxylase activity' >> added synonym 'steroid monooxygenase activity'; but we should probably swap label and synonym, as 'monooxygenase' is broader than hydroxylase

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pgaudet commented Nov 27, 2024

Noting that a sterol is a hydroxysteroid, so we fixed parent/children relations acordingly.

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pgaudet commented Nov 27, 2024

pgaudet added a commit that referenced this issue Nov 27, 2024
pgaudet added a commit that referenced this issue Nov 27, 2024
pgaudet added a commit that referenced this issue Nov 27, 2024
pgaudet added a commit that referenced this issue Nov 27, 2024
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