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fixed parents, xrefs for #29311 #20597
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pgaudet committed Nov 27, 2024
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Showing 1 changed file with 32 additions and 18 deletions.
50 changes: 32 additions & 18 deletions src/ontology/go-edit.obo
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Expand Up @@ -2650,31 +2650,34 @@ is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0000252
name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
name: 3-beta-hydroxysteroid dehydrogenase [NAD(P)]/C4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
def: "Catalysis of the reaction: a 3-beta-hydroxysteroid-4-alpha-carboxylate + NADP+ = a 3-oxosteroid + CO2 + NADPH." [EC:1.1.1.170, PMID:9811880]
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT []
synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED []
synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" EXACT []
synonym: "C-3 sterol dehydrogenase activity" RELATED []
synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED []
synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED []
synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED []
xref: EC:1.1.1.170
xref: RHEA:34771 {source="skos:narrowMatch"}
xref: RHEA:34775 {source="skos:narrowMatch"}
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20597" xsd:anyURI

[Term]
id: GO:0000253
name: 3-keto sterol reductase activity
name: 3-beta-hydroxysteroid 3-dehydrogenase activity
namespace: molecular_function
alt_id: GO:0050576
def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+." [EC:1.1.1.270, GOC:mah, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3-keto sterol reductase activity" EXACT []
synonym: "3-keto-steroid reductase activity" EXACT []
synonym: "3-KSR activity" RELATED [EC:1.1.1.270]
synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270]
Expand All @@ -2684,6 +2687,8 @@ xref: RHEA:18409 {source="skos:narrowMatch"}
xref: RHEA:34787 {source="skos:exactMatch"}
xref: RHEA:36379 {source="skos:narrowMatch"}
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29311" xsd:anyURI

[Term]
id: GO:0000254
Expand Down Expand Up @@ -41630,6 +41635,7 @@ namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]
subset: goslim_pir
synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk]
xref: EC:1.-.-.- {source="skos:broadMatch"}
is_a: GO:0016491 ! oxidoreductase activity

[Term]
Expand Down Expand Up @@ -78422,8 +78428,10 @@ alt_id: GO:0008394
def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]
synonym: "cytochrome P450 CYP2G1" NARROW []
synonym: "olfactory-specific steroid hydroxylase activity" NARROW []
synonym: "steroid monooxygenase activity" EXACT []
xref: EC:1.-.-.- {source="skos:broadMatch"}
is_a: GO:0004497 ! monooxygenase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29029" xsd:anyURI
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29311" xsd:anyURI

[Term]
id: GO:0008396
Expand Down Expand Up @@ -195840,7 +195848,7 @@ is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors,

[Term]
id: GO:0033703
name: 3beta-hydroxy-5beta-steroid dehydrogenase activity
name: 3-beta-hydroxy-5-beta-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + H+ + NADPH." [RHEA:22944]
synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.277]
Expand All @@ -195856,7 +195864,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i

[Term]
id: GO:0033704
name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity
name: 3-beta-hydroxy-5-alpha-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH." [RHEA:18137]
synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.278]
Expand Down Expand Up @@ -196814,7 +196822,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp

[Term]
id: GO:0033778
name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
name: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H+ + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP+." [PMID:10051404, PMID:1400444, RHEA:46752]
synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" RELATED [EC:1.14.14.139]
Expand All @@ -196826,7 +196834,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i

[Term]
id: GO:0033779
name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
name: 5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H+ + NADPH + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H2O + NADP+." [RHEA:15261]
synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" RELATED [EC:1.14.14.139]
Expand Down Expand Up @@ -196873,7 +196881,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp

[Term]
id: GO:0033782
name: 24S-hydroxycholesterol 7alpha-hydroxylase activity
name: 24S-hydroxycholesterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:10748047, PMID:11013305, RHEA:46124]
synonym: "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED []
Expand All @@ -196891,7 +196899,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i

[Term]
id: GO:0033783
name: 25-hydroxycholesterol 7alpha-hydroxylase activity
name: 25-hydroxycholesterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Also converts (25R)-cholest-5-ene-3beta,26-diol to (25R)-cholest-5-en-3beta,7alpha,26-triol." [EC:1.14.14.29]
synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.29]
Expand Down Expand Up @@ -284273,7 +284281,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i

[Term]
id: GO:0047024
name: 5-alpha-androstane-3beta,17beta-diol dehydrogenase (NADP+) activity
name: 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH." [RHEA:16297]
synonym: "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210]
Expand Down Expand Up @@ -284600,6 +284608,7 @@ xref: MetaCyc:1.1.1.64-RXN
xref: RHEA:14981
xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+)
is_a: GO:0030283 ! testosterone dehydrogenase [NAD(P)+] activity
is_a: GO:0072582 ! 17-beta-hydroxysteroid dehydrogenase (NADP+) activity

[Term]
id: GO:0047046
Expand Down Expand Up @@ -296670,7 +296679,9 @@ xref: KEGG_REACTION:R03086
xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN
xref: RHEA:19137
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29311" xsd:anyURI

[Term]
id: GO:0047883
Expand Down Expand Up @@ -310094,8 +310105,9 @@ xref: EC:1.14.99.14
xref: KEGG_REACTION:R02214
xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN
xref: RHEA:18205
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0050214 ! progesterone monooxygenase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29311" xsd:anyURI

[Term]
id: GO:0050213
Expand Down Expand Up @@ -365153,7 +365165,7 @@ id: GO:0062179
name: vitamin D 23-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-23 of any form of vitamin D." [PMID:22100522, PMID:30205156]
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0008395 ! steroid hydroxylase activity
created_by: dph
creation_date: 2019-11-26T17:10:29Z

Expand Down Expand Up @@ -365204,6 +365216,8 @@ namespace: molecular_function
def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:46304]
xref: RHEA:46304
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0008395 ! steroid hydroxylase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/29311" xsd:anyURI
created_by: dph
creation_date: 2019-11-26T18:43:43Z

Expand Down Expand Up @@ -371689,7 +371703,7 @@ synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl]
xref: EC:1.14.15.16 {source="skos:narrowMatch"}
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0008395 ! steroid hydroxylase activity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28340" xsd:anyURI
created_by: mah
creation_date: 2009-04-21T02:20:52Z
Expand Down Expand Up @@ -372558,7 +372572,7 @@ synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah]
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0008395 ! steroid hydroxylase activity
created_by: mah
creation_date: 2009-05-08T03:42:29Z

Expand Down Expand Up @@ -431927,9 +431941,9 @@ replaced_by: GO:0047746

[Term]
id: GO:0102294
name: cholesterol dehydrogenase activity
name: cholesterol dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NA+D = cholest-5-en-3-one + NADH + H+." [RHEA:35459]
def: "Catalysis of the reaction: cholesterol + NAD+ = cholest-5-en-3-one + NADH + H+." [RHEA:35459]
xref: MetaCyc:RXN-12693
xref: RHEA:35459
is_a: GO:0003854 ! 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity
Expand Down

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