v1.0.0

Added

• RNA004 models
• R941 v3.3 5mCG 5hmCG models
• Duplex calling with option --duplex
  • Note that duplex calling is not optimised for streaming basecalling with --watch_path and may lead to lower duplex yield.
  • Duplex basecalling is currently not compatible with modified basecalling.

Changed

• Updated Dorado to v0.3.2 (see https://github.com/nanoporetech/dorado/releases/tag/v0.3.2)
• Pascal architecture GPUs are now supported
• Bumped minimum required Nextflow version to 23.04.2
• Users no longer need to provide --basecaller_cfg custom and/or --remora_cfg custom to override models with --basecaller_model_path and/or --remora_model_path respectively.

Fixed

• bamstats process very slow when output_bam has been selected