This was a reprocessing of published single-cell RNA seqeuncing studies focused on myeloid cell populations We identified a population of metallothionein specific macrophages in this study, validate their presence in multiple studies and propose biological function/relevance via dowbstream analyses.
In this meta analysis, we obtained sequencing data from Geo GSE136103, Zenodo 10.5281/ze-243nodo.4059315, Geo GSE136831
In order to replicate this analysis, or just track our analytical path, please follow the following path of scripts
pub-preprocessing.R --> pub-processing.R --> pub-myeloid-processing.R --> figures.Rmd
The corresponding data should be available in our GEO repository for processed data (GEO #).
If you have any questions regarding the analysis, please reach out to Joe Daccache ([email protected])