miRNASNP-v3

Cite

Liu, C. J., Fu, X., Xia, M., Zhang, Q., Gu, Z., & Guo, A. Y. (2020). miRNASNP-v3: a comprehensive database for SNPs and disease-related variations in miRNAs and miRNA targets. Nucleic Acids Research.

Summary

microRNAs (miRNAs) are endogenous and regulatory non-coding RNAs by targeting mRNAs for cleavage or translational repression. SNPs on pre-miRNAs or target sites will affect miRNA expression or functions. miRNASNP is a comprehensive resource of human miRNA-related SNPs, including their effects on target gain and loss. In miRNASNP-v3, 6,363,450 SNPs on human 1,897 pre-miRNAs(2,624 mature miRNAs) and 3'UTRs of 18,152 genes were characterized. Besides, 203,471 mutations from ClinVar and COSMIC were identified on the pre-miRNAs(2,065 on mature miRNAs, 522 on seed regions) and 3'UTRs. Gene enrichment of targets gained or lost by SNP in the miRNA seed region is provided.

Improved content and new features

• SNPs in pre-miRNAs and their impacts on miRNAs.
• Target gain/loss by SNPs in miRNA seed and gene 3'UTR.
• Online tools to predict novel SNP effect on miRNA function.
• Experiment validated miRNA:gene interaction.
• Expression and correlation of miRNAs and genes.
• Gene enrichment of miRNA target gain and loss.
• DRVs (GWAS, ClinVAR, COSMIC) in miRNA and 3'UTR.
• DRVs impact miRNA target gain/loss and secondary structure.
• Correlation of drug sensitivity and miRNAs.

The workflow of miRNASNP-v3