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Add August entry
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Lorenz-U committed Dec 1, 2024
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---
title: "Wonderful Wednesdays August 2024"
description: |
When a new patient-reported outcome (PRO) is developed, there is interest in deriving the following, to support interpretation of data collected using the new tool: Minimal Clinically Important Difference (MCID) / Responder Definition (RD), Meaningful Between-Group Difference, Meaningful Score Categories. These are usually derived by using an existing, validated measure as the ‘gold standard’ to quantify e.g. disease status.
author:
- name: PSI VIS SIG
url: https://www.psiweb.org/sigs-special-interest-groups/visualisation
date: 08-14-2024
categories:
- Responder definition
- Wonderful Wednesdays
base_url: https://vis-sig.github.io/blog
preview: ./images/improvement.png
output:
distill::distill_article:
self_contained: false
---


# Responder definition
When a new patient-reported outcome (PRO) is developed, there is interest in deriving the following, to support interpretation of data collected using the new tool: Minimal Clinically Important Difference (MCID) / Responder Definition (RD), Meaningful Between-Group Difference, Meaningful Score Categories. These are usually derived by using an existing, validated measure as the ‘gold standard’ to quantify e.g. disease status.

Challenge: Use visualisations to support in the derivation in any or all of the following:

- MCID
- Meaningful between-group difference
- Meaningful score categories


A description of the challenge can be found [here](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-07-10).
A recording of the session can be found [here](https://psiweb.org/vod/item/psi-vissig-wonderful-wednesday-53-responder-definition-derivation).

<a id="example1"></a>

## Example 1. Part 1

![](./images/summary_statistics.png)
[high resolution image](./images/summary_statistics.png)

![](./images/improvement.png)
[high resolution image](./images/improvement.png)

![](./images/pdf_curves.png)
[high resolution image](./images/pdf_curves.png)

![](./images/additional_summary_statistics.png)
[high resolution image](./images/additional_summary_statistics.png)

[link to code](#example1 code)


<a id="example2"></a>

## Example 2. Part 2

![](./images/meaningful_severity.png)
[high resolution image](./images/meaningful_severity.png)

![](./images/roc_curves.png)
[high resolution image](./images/roc_curves.png)

[link to code](#example2 code)

<a id="example3"></a>

## Example 3. November 2021

![](./images/uncertainty.png)
[high resolution image](./images/uncertainty.png)

![](./images/minimally_improved.png)
[high resolution image](./images/minimally_improved.png)

![](./images/cgi-i.png)
[high resolution image](./images/cgi-i.png)

![](./images/threshold.png)
[high resolution image](./images/threshold.png)

![](./images/cgi-i_rating.jpg)
[high resolution image](./images/cgi-i_rating.jpg)

![](./images/baseline_follow-up_change.png)
[high resolution image](./images/baseline_follow-up_change.png)

[link to code](#example3 code)

<a id="example4"></a>




# Code

<a id="example1 code"></a>

## Example 1. <Same title as above>

No code has been submitted.


[Back to blog](#example1)



<a id="example2 code"></a>

## Example 2. <Same title as above>

No code has been submitted.


[Back to blog](#example2)


<a id="example3 code"></a>

## Example 3. <Same title as above>

No code has been submitted.

[Back to blog](#example3)
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