Removing --contamination-table from FilterMutectCalls due to causing …

…low recall with SEQC2 TN pair
OpenOmics · Oct 30, 2024 · 613d69e · 613d69e
1 parent 3d06f7d
commit 613d69e
Showing 1 changed file with 4 additions and 2 deletions.
diff --git a/workflow/rules/somatic.smk b/workflow/rules/somatic.smk
@@ -609,12 +609,14 @@ rule gatk_filter_mutect2:
         config['tools']['gatk4'],
         config['tools']['vcftools'],
     shell: """
-    # Mutect2 orien bias filter
+    # Mutect2 orien bias filter,
+    # removing the contamination filter 
+    # option due to causing low recall
+    # with SEQC2 truth set
     gatk FilterMutectCalls \\
         -R {params.genome} \\
         -V {input.vcf} \\
         --ob-priors {input.orien} \\
-        --contamination-table {input.summary} \\
         -O {output.vcf} \\
         --stats {input.stats} 
     """