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## Basic Physics

Any atomic nucleous with an odd numer of nucleons has spin different from zero and so, a magnetic moment (magnetic dipole).
In the body, we can find several atoms with magnetic moment such as H, P, C, F, Na. Around 60% of the human body is made up
of water that contains hydrogen, which is also present in proteins and lipids. For this reason, hydrogen is very sensitive
to magnetic fields and MRI takes advantage of this phenomenom.
In the body, we can find several atoms with magnetic moment such as H, P, C, F, Na, which are sensitive to magnetic resonance.
Around 60% of the human body is made up of water that contains hydrogen, which is also present in proteins and lipids.
For this reason, hydrogen is the most widely used in MRI.

atoms with magnetic dipole

MRI bore contains a powerful magnet which generates an uniform magnetic field B0. Patiens are introduced in this magnetic field
and hydrogen atoms align to the magnetic field. According to Larmour's law,a magnetic dipole inside a magnetic field
and hydrogen atoms align to the magnetic field. According to Larmour's law, a magnetic dipole inside a magnetic field
precesses (spins) arround the magnetic field with a frequency proportional to the magnetic field strength. Hence, hydrogen atoms
precess arround the magnetic field generated by the MR.
precess arround the magnetic field generated by the MR with a frequency (Larmour frequency) that follows the equation:

w = γ B0

![](https://www.frontiersin.org/files/Articles/427144/frym-07-00023-HTML-r2/image_m/figure-2.jpg)
This precession can be parallel or antiparallel to B0. In the body the number of atoms that precess parallel is different to
the ones that precess antiparallel inducing an small magnetic field which is proportional to B0 and also depends on the density
od hydrogen nuclei. To sum up, static magnetic field (B0) induces a slight magnetization of tissues.
the ones that precess antiparallel producing an small magnetic field which is proportional to B0 and also depends on the density
of hydrogen nuclei. So, the static magnetic field (B0) induces a slight magnetization of tissues.

---- (induced magnetization inside the bore)

(Mx, My, Mz)

Then, a radiofrequency pulse is emitted perpendicular to B0 with the same frequency that the spin precession frequency.Hydrogen atoms
abrosrb energy and spin out of equilibrium.Then, when the RF dissapears, the magnetic momentum gradually goes back to te minimum
abrosrb energy and spin out of equilibrium. Longitudinal magnetization (Mz) of protons in a parallel direction to B0 decreases, and a
transverse magnetization (Mx, My) appears.

Then, when the RF dissapears, the magnetic momentum gradually goes back to te minimum
energy position (magnetic relaxation) while releasing energy. This emited signals are measured into the k-space which is an array
of numbers representing spatial frequencies in the MR image. Each k-space point contains spatial frequency and phase information
about every pixel in the final image. Fourier transformed is performed to the k-space to obtain the final image. By varying the
of numbers representing spatial frequencies in the MR image. (Each k-space point contains spatial frequency and phase information
about every pixel in the final image). Fourier transforme is performed to the k-space to obtain the final image. By varying the
sequence of RF pulses applied & collected, different types of images are created.

-TR
-TE
The angle the magnetization is shifted, is a parameter to be defined
(Flip angle) and depends on the intensity and duration of the RF pulse.

### MRI Sequences

The most common sequences are T1-weighted and T2-weighted images. In neuroimaging, T1-weighted images are commonly used in anatomical
related studies, they are based in longitudinal relaxation and are produced with short TR and TE.
(explicar longitudinal relaxation My, T1).(...)
It's important to understand the meaning of **repetition time (TR)** and **echo time (TE)** in order to comprehend the main
MRI sequences. Time to Echo (TE) is the time between the delivery of the RF pulse and the receipt of the echo signal and
the interval between subsequent pulse sequences delivered to the same slice is known as the repetition time (TR).

The most common sequences are T1-weighted and T2-weighted images. In neuroimaging, **T1-weighted** images are commonly used in anatomical
related studies, they are based on the study of the relaxation of the nuclei in the longitudinal component (Mz) of the magnetization
vector and are produced with short TR and TE.**T2-weighted** images are produced with longer TR and TE. They are based on study of the
variations of the component on the transverse plane of the magnetization during the relaxation, known as transverse relaxation (Mxy).

T2-weighted images are produced with longer TR and TE. They are based on study of the variations of the component on the transverse
plane of the magnetization during the relaxation, known as transverse relaxation (Mxy).
There are many sequences that can be used depending on the objective. T

## Multi-echo


## Bibliography
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