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Hugo Blox Builder - Import latest publications
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alexpron authored Aug 2, 2024
2 parents 367e806 + c29426e commit 891e59b
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12 changes: 12 additions & 0 deletions content/publication/field-consequences-2024/cite.bib
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@article{field_consequences_2024,
doi = {https://doi.org/10.36850/jote.i4.1},
editor = {Field, Sarahanne M. and van Dongen, Noah and Tiokhin, Leo and 0'Mahony, Aoife and Kaplan, Rebecca and Visser, Alex and Robaard, Meike and Prinsen, Jip and Korna, Thomas F.K.},
issn = {2667-1204},
language = {en},
month = {May},
note = {Special Issue},
number = {1},
title = {Consequences of the Scientfic Reform Movement},
volume = {4},
year = {2024}
}
18 changes: 18 additions & 0 deletions content/publication/field-consequences-2024/index.md
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---
title: Consequences of the Scientfic Reform Movement
authors:
- Sarahanne M. Field
- Noah van Dongen
- Leo Tiokhin
- Aoife 0'Mahony
- Rebecca Kaplan
- Alex Visser
- Meike Robaard
- Jip Prinsen
- Thomas F.K. Korna
date: '2024-05-01'
publishDate: '2024-08-02T08:28:50.563187Z'
publication_types:
- article-journal
doi: https://doi.org/10.36850/jote.i4.1
---
40 changes: 40 additions & 0 deletions content/publication/mandl-addressing-2024/cite.bib
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@article{mandl_addressing_2024,
abstract = {Abstract
When different researchers study the same research question using the same dataset they may obtain different and potentially even conflicting results. This is because there is often substantial flexibility in researchers’ analytical choices, an issue also referred to as “researcher degrees of freedom”. Combined with selective reporting of the smallest
p
-value or largest effect, researcher degrees of freedom may lead to an increased rate of false positive and overoptimistic results. In this paper, we address this issue by formalizing the multiplicity of analysis strategies as a multiple testing problem. As the test statistics of different analysis strategies are usually highly dependent, a naive approach such as the Bonferroni correction is inappropriate because it leads to an unacceptable loss of power. Instead, we propose using the “minP” adjustment method, which takes potential test dependencies into account and approximates the underlying null distribution of the minimal
p
-value through a permutation-based procedure. This procedure is known to achieve more power than simpler approaches while ensuring a weak control of the family-wise error rate. We illustrate our approach for addressing researcher degrees of freedom by applying it to a study on the impact of perioperative
\$\$paO_2\$\$
p
a
O
2
on post-operative complications after neurosurgery. A total of 48 analysis strategies are considered and adjusted using the minP procedure. This approach allows to selectively report the result of the analysis strategy yielding the most convincing evidence, while controlling the type 1 error—and thus the risk of publishing false positive results that may not be replicable.},
author = {Mandl, Maximilian M. and Becker-Pennrich, Andrea S. and Hinske, Ludwig C. and Hoffmann, Sabine and Boulesteix, Anne-Laure},
doi = {10.1186/s12874-024-02279-2},
file = {Mandl et al. - 2024 - Addressing researcher degrees of freedom through m.pdf:/home/alpron/Zotero/storage/DZMEFP7J/Mandl et al. - 2024 - Addressing researcher degrees of freedom through m.pdf:application/pdf},
issn = {1471-2288},
journal = {BMC Medical Research Methodology},
keywords = {multiverse, to read},
language = {en},
month = {July},
number = {1},
pages = {152},
title = {Addressing researcher degrees of freedom through minP adjustment},
url = {https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-024-02279-2},
urldate = {2024-08-01},
volume = {24},
year = {2024}
}
42 changes: 42 additions & 0 deletions content/publication/mandl-addressing-2024/index.md
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---
title: Addressing researcher degrees of freedom through minP adjustment
authors:
- Maximilian M. Mandl
- Andrea S. Becker-Pennrich
- Ludwig C. Hinske
- Sabine Hoffmann
- Anne-Laure Boulesteix
date: '2024-07-01'
publishDate: '2024-08-02T08:28:50.549122Z'
publication_types:
- article-journal
publication: '*BMC Medical Research Methodology*'
doi: 10.1186/s12874-024-02279-2
abstract: Abstract When different researchers study the same research question using
the same dataset they may obtain different and potentially even conflicting results.
This is because there is often substantial flexibility in researchers’ analytical
choices, an issue also referred to as “researcher degrees of freedom”. Combined
with selective reporting of the smallest p -value or largest effect, researcher
degrees of freedom may lead to an increased rate of false positive and overoptimistic
results. In this paper, we address this issue by formalizing the multiplicity of
analysis strategies as a multiple testing problem. As the test statistics of different
analysis strategies are usually highly dependent, a naive approach such as the Bonferroni
correction is inappropriate because it leads to an unacceptable loss of power. Instead,
we propose using the “minP” adjustment method, which takes potential test dependencies
into account and approximates the underlying null distribution of the minimal p
-value through a permutation-based procedure. This procedure is known to achieve
more power than simpler approaches while ensuring a weak control of the family-wise
error rate. We illustrate our approach for addressing researcher degrees of freedom
by applying it to a study on the impact of perioperative $$paO_2$$ p a O 2 on
post-operative complications after neurosurgery. A total of 48 analysis strategies
are considered and adjusted using the minP procedure. This approach allows to selectively
report the result of the analysis strategy yielding the most convincing evidence,
while controlling the type 1 error—and thus the risk of publishing false positive
results that may not be replicable.
tags:
- multiverse
- to read
links:
- name: URL
url: https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-024-02279-2
---

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