Modelling the effect of experimental conditions that influence rundown of L-type calcium current

This repository contains all data, protocols, codes, and figure generating files used in this study.

Table of Contents

• run.py runs all figure generating files in the figures and supporting directory
• helpers.py provides supporting functions used by the figure generating files
• parameters.py has the values of the parameters used
• The resources directory has model and other files from previous experiments used as input here
• The supporting directory has output generating files used for ExtendedData.ipynb
• The figures directory has the files that generate all figures in the paper and their output
• Supporting material for the paper is provided at ExtendedData.ipynb

Software

• Python The code requires Python (version 3.3+) and the Python dependencies myokit and pints
  • The Python packages used in this project can be installed by running pip install -r requirements.txt in an environment with Python 3.10.11

Hardware

• Some of the scripts require high processing, and the results here were generated on 20 CPU cores of a x86_64 Intel(R) Xeon(R) (3.00GHz) system