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A biological insight on stemness score negatively correlated #6

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andynkili opened this issue May 2, 2023 · 0 comments
Open

A biological insight on stemness score negatively correlated #6

andynkili opened this issue May 2, 2023 · 0 comments

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@andynkili
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Dear developers,

Thank you for your useful tools.

I am currently working on a dataset where cell types are hard to define, thus we don't know if there are any progenitors.
I use the 5 scores (ESC+iPSC, EB, ED, ECTO, MESO) to see any correlations between those.
Something I cannot wrap my head around is why some scores are highly negatively correlated (e.g Embryoid bodies and ESC+iPSC, correlation=-0.9) in different samples. Because of their nature (developmental) I was expecting those 2 scores to be positively correlated.
What does the high negative correlation mean, biologically and how should I determine which score(s) is(are) accurate?

Andy

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