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Fixed duplicate title in 2023_12 release article
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adelbke authored Dec 21, 2023
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## **DisProt 2023_12 - New thematic dataset of condensates-related intrinsically disordered proteins **

**DisProt team provides a collection of manually curated proteins driving liquid-liquid phase separation (LLPS) and Membraneless Organelles (MLO) related protein formation.**

_Written in December, 2023, by Maria Cristina Aspromonte_


# **New thematic dataset of condensates-related proteins**

One of the recent key concepts in molecular biology is represented by the presence and characterization of membraneless compartments, which play a fundamental role in concentrating proteins and nucleic acids, fulfilling important cellular functions. The formation of these compartments is guided by the molecular process liquid–liquid phase separation (LLPS) and is characterized by the presence of molecules enriched in intrinsically disordered regions (IDRs) with a variety of different properties. The construction of the new dataset involves proteins for which experimental evidence has demonstrated their role in phase separation and the formation of membraneless compartments. We relied on the literature as well as manually curated databases such as [PhasePro](https://phasepro.elte.hu/) and [PhaSeDB](http://db.phasep.pro/), which collect proteins implicated in these processes.
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