Deep brain stimulation (DBS) is proving to be an effective treatment for severe, treatment resistant depression (TRD). One of the most well-studied targets for DBS is the subcallosal cingulate cortex (SCC), and demonstrations of SCC-DBS have yielded positive \cite{} but equivocal \cite{} results.
DBS of the SCCwm targets specific tracts in the brain that likely mediate the immediate effects. Source: https://med.emory.edu/education/vme/pages/gallery/pf-dbs-depression-image.html
Precise stimulation of the subcallosal cingulate white matter (SCCwm) is now thought to be necessary to achieve antidepressant effect when implementing SCC-DBS. However, we need objective signatures to confirm, study, and engineer around antidepressant SCCwm-DBS. Neural recordings are a great modality to derive and use these objective signatures.
This repository contains all the code needed to regenerate the figures from Chapter ? from my dissertation. This chapter is focused on characterized the direct effects of SCCwm-DBS across whole-brain networks - its network action.
This repository requires the custom library DBSpace
Preprint: Network Action of...
First, I wanted to understand where in the brain we would see changes - locally around the SCCwm target, remotely in scalp-measurable cortex, some combination of both, or neither. This gives us the spatial modes of the network action.
With an eye towards temporal changes, we studied the immediate effects of SCCwm-DBS on the trajectory of wide-brain oscillatory activity.
The code for this publication is in the analysis/DOs folder.
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