interacting_pair is ligand_receptor or receptor_ligand?

[yanwuanxin]

interacting_pair is ligand_receptor or receptor_ligand?

[yanwuanxin]

celltypeA|celltypeB which is celtype of ligand, which is celltype of receptor？

[cakirb]

Hi @yanwuanxin,

You can check for the details of the interactions from "directionality" column since there are some interactions different than ligand-receptor. If an interaction was annotated as ligand-receptor, it is a ligand-receptor, not receptor-ligand.

Hope this helps you!

Best,
Batu

[yanwuanxin]

what does the mean of Ligand-Ligand？does the interacting_pair have practical significance?

[cakirb]

Hi @yanwuanxin,

Our database curators are currently not available to comment, but we've noticed that all ligand-ligand interactions have 'inhibitory' set in 'modulatory effect' column in interaction_input.csv. You can see the 'source' column to see where each interaction is coming from. For example, HHIP inhibiting Sonic Hedgehog (SSH) pathway by binding to SSH and sequestering it (see https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8660895&blobtype=pdf).

Hope that helps!

Best,
Batu

[yanwuanxin]

thank you for your answer.