Covariates used for condition-by-condition analyses

[ghost]

Hi,

Would it be a problem for mash if different covariates or different numbers of covariates were used in the condition-by-condition analyses?

For example, in an eQTL scenario where different numbers of expression principal components or PEER factors were used as covariates for each condition.

Thank you.

[stephens999]

the short answer is that this should not cause big problems for mashr. It could impact interpretation of the coefficients being estimated, but the estimates themselves should remain reliable.

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On Mon, Jan 24, 2022 at 6:08 AM crvcheet21 ***@***.***> wrote: Hi, Would it be a problem for mash if different covariates or different numbers of covariates were used in the condition-by-condition analyses? For example, in an eQTL scenario where different numbers of expression principal components or PEER factors were used as covariates for each condition. Thank you. — Reply to this email directly, view it on GitHub <#103>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AANXRRLSMIZDUHWACICMGKTUXU6LTANCNFSM5MVGCSZQ> . Triage notifications on the go with GitHub Mobile for iOS <https://apps.apple.com/app/apple-store/id1477376905?ct=notification-email&mt=8&pt=524675> or Android <https://play.google.com/store/apps/details?id=com.github.android&referrer=utm_campaign%3Dnotification-email%26utm_medium%3Demail%26utm_source%3Dgithub>. You are receiving this because you are subscribed to this thread.Message ID: ***@***.***>