diff --git a/.changes/unreleased/Fixes-20230810-233738.yaml b/.changes/unreleased/Fixes-20230810-233738.yaml
new file mode 100644
index 00000000..62aeea20
--- /dev/null
+++ b/.changes/unreleased/Fixes-20230810-233738.yaml
@@ -0,0 +1,7 @@
+kind: Fixes
+body: Only set the comment when persist_docs.relation is set
+time: 2023-08-10T23:37:38.828664+02:00
+custom:
+  Author: Fokko
+  Issue: "317"
+  PR: "343"
diff --git a/dbt/include/trino/macros/adapters.sql b/dbt/include/trino/macros/adapters.sql
index 32362349..2228934e 100644
--- a/dbt/include/trino/macros/adapters.sql
+++ b/dbt/include/trino/macros/adapters.sql
@@ -89,8 +89,12 @@
 {%- endmacro -%}
 
 {% macro comment(comment) %}
-  {%- if comment is not none and comment|length > 0 -%}
-      comment '{{ comment | replace("'", "''") }}'
+  {%- set persist_docs = model['config'].get('persist_docs') -%}
+  {%- if persist_docs -%}
+    {%- set persist_relation = persist_docs.get('relation') -%}
+    {%- if persist_relation and comment is not none and comment|length > 0 -%}
+        comment '{{ comment | replace("'", "''") }}'
+    {%- endif -%}
   {%- endif -%}
 {%- endmacro -%}
 
diff --git a/tests/functional/adapter/persist_docs/test_persist_docs.py b/tests/functional/adapter/persist_docs/test_persist_docs.py
index 4d681203..01640c70 100644
--- a/tests/functional/adapter/persist_docs/test_persist_docs.py
+++ b/tests/functional/adapter/persist_docs/test_persist_docs.py
@@ -1,10 +1,11 @@
 import pytest
 from dbt.tests.adapter.persist_docs.test_persist_docs import (
     BasePersistDocs,
+    BasePersistDocsBase,
     BasePersistDocsColumnMissing,
     BasePersistDocsCommentOnQuotedColumn,
 )
-from dbt.tests.util import run_dbt
+from dbt.tests.util import run_dbt, run_sql_with_adapter
 
 from tests.functional.adapter.persist_docs.fixtures import (
     incremental_model,
@@ -142,3 +143,60 @@ class TestPersistDocsColumnMissing(BasePersistDocsColumnMissing):
 
 class TestPersistDocsCommentOnQuotedColumn(BasePersistDocsCommentOnQuotedColumn):
     pass
+
+
+class BasePersistDocsDisabled(BasePersistDocsBase):
+    def test_persist_docs_disabled(self, project):
+        sql = f"""select * from system.metadata.table_comments
+        where catalog_name = '{project.database}'
+        and schema_name = '{project.test_schema}'
+        and table_name = 'table_model'
+        and comment is not null
+        """
+        result = run_sql_with_adapter(project.adapter, sql, fetch="all")
+        assert len(result) == 0
+
+
+class TestPersistDocsDisabledByDefault(BasePersistDocsDisabled):
+    """
+    Without providing `persist_docs` config, table comments shouldn't be added by default.
+    """
+
+    pass
+
+
+class TestPersistDocsRelationSetToFalse(BasePersistDocsDisabled):
+    """
+    With `persist_docs.relation` config set to False, table comments shouldn't be added.
+    """
+
+    @pytest.fixture(scope="class")
+    def project_config_update(self):
+        return {
+            "models": {
+                "test": {
+                    "+persist_docs": {
+                        "relation": False,
+                        "columns": True,
+                    },
+                }
+            }
+        }
+
+
+class TestPersistDocsRelationNotSet(BasePersistDocsDisabled):
+    """
+    Without providing `persist_docs.relation` config, table comments shouldn't be added by default.
+    """
+
+    @pytest.fixture(scope="class")
+    def project_config_update(self):
+        return {
+            "models": {
+                "test": {
+                    "+persist_docs": {
+                        "columns": True,
+                    },
+                }
+            }
+        }