diff --git a/.changes/unreleased/Fixes-20230810-233738.yaml b/.changes/unreleased/Fixes-20230810-233738.yaml
new file mode 100644
index 00000000..62aeea20
--- /dev/null
+++ b/.changes/unreleased/Fixes-20230810-233738.yaml
@@ -0,0 +1,7 @@
+kind: Fixes
+body: Only set the comment when persist_docs.relation is set
+time: 2023-08-10T23:37:38.828664+02:00
+custom:
+  Author: Fokko
+  Issue: "317"
+  PR: "343"
diff --git a/dbt/include/trino/macros/adapters.sql b/dbt/include/trino/macros/adapters.sql
index 32362349..2228934e 100644
--- a/dbt/include/trino/macros/adapters.sql
+++ b/dbt/include/trino/macros/adapters.sql
@@ -89,8 +89,12 @@
 {%- endmacro -%}
 
 {% macro comment(comment) %}
-  {%- if comment is not none and comment|length > 0 -%}
-      comment '{{ comment | replace("'", "''") }}'
+  {%- set persist_docs = model['config'].get('persist_docs') -%}
+  {%- if persist_docs -%}
+    {%- set persist_relation = persist_docs.get('relation') -%}
+    {%- if persist_relation and comment is not none and comment|length > 0 -%}
+        comment '{{ comment | replace("'", "''") }}'
+    {%- endif -%}
   {%- endif -%}
 {%- endmacro -%}