goref-0000033.md

authors	external_accession	id	url	year	layout
Pascale Gaudet, Michael Livstone, Paul Thomas, The Reference Genome Project	SGD_REF:S000146947 TAIR:Communication:501741973 MGI:MGI:4459044 J:161428 PAINT_REF:[0-9]{7} ZFIN:ZDB-PUB-110330-1 FB:FBrf0232076	GO_REF:0000033	http://gocwiki.geneontology.org/index.php/PAINT	2010	goref

Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes.To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).