diff --git a/src/imgui/renderer/imgui_core.cpp b/src/imgui/renderer/imgui_core.cpp
index d52536f68f..1bbc20b8ff 100644
--- a/src/imgui/renderer/imgui_core.cpp
+++ b/src/imgui/renderer/imgui_core.cpp
@@ -79,7 +79,11 @@ void OnResize() {
 }
 
 void Shutdown(const vk::Device& device) {
-    device.waitIdle();
+    auto result = device.waitIdle();
+    if (result != vk::Result::eSuccess) {
+        LOG_WARNING(ImGui, "Failed to wait for Vulkan device idle on shutdown: {}",
+                    vk::to_string(result));
+    }
 
     TextureManager::StopWorker();
 
diff --git a/src/imgui/renderer/imgui_impl_vulkan.h b/src/imgui/renderer/imgui_impl_vulkan.h
index ca76fda6d9..e325e2a8dc 100644
--- a/src/imgui/renderer/imgui_impl_vulkan.h
+++ b/src/imgui/renderer/imgui_impl_vulkan.h
@@ -5,7 +5,6 @@
 
 #pragma once
 
-#define VULKAN_HPP_NO_EXCEPTIONS
 #include "common/types.h"
 #include "video_core/renderer_vulkan/vk_common.h"
 
diff --git a/src/video_core/buffer_cache/buffer.cpp b/src/video_core/buffer_cache/buffer.cpp
index 7029580344..7476f80343 100644
--- a/src/video_core/buffer_cache/buffer.cpp
+++ b/src/video_core/buffer_cache/buffer.cpp
@@ -129,9 +129,11 @@ vk::BufferView Buffer::View(u32 offset, u32 size, bool is_written, AmdGpu::DataF
         .range = size,
     };
     const auto view = instance->GetDevice().createBufferView(view_ci);
+    ASSERT_MSG(view.result == vk::Result::eSuccess, "Failed to create buffer view: {}",
+               vk::to_string(view.result));
     scheduler->DeferOperation(
-        [view, device = instance->GetDevice()] { device.destroyBufferView(view); });
-    return view;
+        [view, device = instance->GetDevice()] { device.destroyBufferView(view.value); });
+    return view.value;
 }
 
 constexpr u64 WATCHES_INITIAL_RESERVE = 0x4000;
diff --git a/src/video_core/renderer_vulkan/renderer_vulkan.cpp b/src/video_core/renderer_vulkan/renderer_vulkan.cpp
index d019ff0346..f3403fd980 100644
--- a/src/video_core/renderer_vulkan/renderer_vulkan.cpp
+++ b/src/video_core/renderer_vulkan/renderer_vulkan.cpp
@@ -82,7 +82,10 @@ RendererVulkan::RendererVulkan(Frontend::WindowSDL& window_, AmdGpu::Liverpool*
     present_frames.resize(num_images);
     for (u32 i = 0; i < num_images; i++) {
         Frame& frame = present_frames[i];
-        frame.present_done = device.createFence({.flags = vk::FenceCreateFlagBits::eSignaled});
+        auto fence_result = device.createFence({.flags = vk::FenceCreateFlagBits::eSignaled});
+        ASSERT_MSG(fence_result.result == vk::Result::eSuccess,
+                   "Failed to create present done fence: {}", vk::to_string(fence_result.result));
+        frame.present_done = fence_result.value;
         free_queue.push(&frame);
     }
 
@@ -157,7 +160,10 @@ void RendererVulkan::RecreateFrame(Frame* frame, u32 width, u32 height) {
             .layerCount = 1,
         },
     };
-    frame->image_view = device.createImageView(view_info);
+    auto view_result = device.createImageView(view_info);
+    ASSERT_MSG(view_result.result == vk::Result::eSuccess, "Failed to create frame image view: {}",
+               vk::to_string(view_result.result));
+    frame->image_view = view_result.value;
     frame->width = width;
     frame->height = height;
 }
diff --git a/src/video_core/renderer_vulkan/vk_common.h b/src/video_core/renderer_vulkan/vk_common.h
index a2f9cbcaf7..e23de78e0d 100644
--- a/src/video_core/renderer_vulkan/vk_common.h
+++ b/src/video_core/renderer_vulkan/vk_common.h
@@ -14,6 +14,7 @@
 #define VULKAN_HPP_NO_CONSTRUCTORS
 #define VULKAN_HPP_NO_STRUCT_SETTERS
 #define VULKAN_HPP_HAS_SPACESHIP_OPERATOR
+#define VULKAN_HPP_NO_EXCEPTIONS
 #include <vulkan/vulkan.hpp>
 
 #define VMA_STATIC_VULKAN_FUNCTIONS 0
diff --git a/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp b/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp
index 96358bf67a..3760c3fe06 100644
--- a/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp
+++ b/src/video_core/renderer_vulkan/vk_compute_pipeline.cpp
@@ -77,7 +77,12 @@ ComputePipeline::ComputePipeline(const Instance& instance_, Scheduler& scheduler
         .bindingCount = static_cast<u32>(bindings.size()),
         .pBindings = bindings.data(),
     };
-    desc_layout = instance.GetDevice().createDescriptorSetLayoutUnique(desc_layout_ci);
+    auto descriptor_set_result =
+        instance.GetDevice().createDescriptorSetLayoutUnique(desc_layout_ci);
+    ASSERT_MSG(descriptor_set_result.result == vk::Result::eSuccess,
+               "Failed to create compute descriptor set layout: {}",
+               vk::to_string(descriptor_set_result.result));
+    desc_layout = std::move(descriptor_set_result.value);
 
     const vk::DescriptorSetLayout set_layout = *desc_layout;
     const vk::PipelineLayoutCreateInfo layout_info = {
@@ -86,19 +91,20 @@ ComputePipeline::ComputePipeline(const Instance& instance_, Scheduler& scheduler
         .pushConstantRangeCount = 1U,
         .pPushConstantRanges = &push_constants,
     };
-    pipeline_layout = instance.GetDevice().createPipelineLayoutUnique(layout_info);
+    auto layout_result = instance.GetDevice().createPipelineLayoutUnique(layout_info);
+    ASSERT_MSG(layout_result.result == vk::Result::eSuccess,
+               "Failed to create compute pipeline layout: {}", vk::to_string(layout_result.result));
+    pipeline_layout = std::move(layout_result.value);
 
     const vk::ComputePipelineCreateInfo compute_pipeline_ci = {
         .stage = shader_ci,
         .layout = *pipeline_layout,
     };
-    auto result =
+    auto pipeline_result =
         instance.GetDevice().createComputePipelineUnique(pipeline_cache, compute_pipeline_ci);
-    if (result.result == vk::Result::eSuccess) {
-        pipeline = std::move(result.value);
-    } else {
-        UNREACHABLE_MSG("Graphics pipeline creation failed!");
-    }
+    ASSERT_MSG(pipeline_result.result == vk::Result::eSuccess,
+               "Failed to create compute pipeline: {}", vk::to_string(pipeline_result.result));
+    pipeline = std::move(pipeline_result.value);
 }
 
 ComputePipeline::~ComputePipeline() = default;
diff --git a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
index f7474b24ec..8c5a59483d 100644
--- a/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
+++ b/src/video_core/renderer_vulkan/vk_graphics_pipeline.cpp
@@ -39,7 +39,11 @@ GraphicsPipeline::GraphicsPipeline(const Instance& instance_, Scheduler& schedul
         .pushConstantRangeCount = 1,
         .pPushConstantRanges = &push_constants,
     };
-    pipeline_layout = instance.GetDevice().createPipelineLayoutUnique(layout_info);
+    auto layout_result = instance.GetDevice().createPipelineLayoutUnique(layout_info);
+    ASSERT_MSG(layout_result.result == vk::Result::eSuccess,
+               "Failed to create graphics pipeline layout: {}",
+               vk::to_string(layout_result.result));
+    pipeline_layout = std::move(layout_result.value);
 
     boost::container::static_vector<vk::VertexInputBindingDescription, 32> bindings;
     boost::container::static_vector<vk::VertexInputAttributeDescription, 32> attributes;
@@ -280,12 +284,10 @@ GraphicsPipeline::GraphicsPipeline(const Instance& instance_, Scheduler& schedul
         .layout = *pipeline_layout,
     };
 
-    auto result = device.createGraphicsPipelineUnique(pipeline_cache, pipeline_info);
-    if (result.result == vk::Result::eSuccess) {
-        pipeline = std::move(result.value);
-    } else {
-        UNREACHABLE_MSG("Graphics pipeline creation failed!");
-    }
+    auto pipeline_result = device.createGraphicsPipelineUnique(pipeline_cache, pipeline_info);
+    ASSERT_MSG(pipeline_result.result == vk::Result::eSuccess,
+               "Failed to create graphics pipeline: {}", vk::to_string(pipeline_result.result));
+    pipeline = std::move(pipeline_result.value);
 }
 
 GraphicsPipeline::~GraphicsPipeline() = default;
@@ -343,7 +345,10 @@ void GraphicsPipeline::BuildDescSetLayout() {
         .bindingCount = static_cast<u32>(bindings.size()),
         .pBindings = bindings.data(),
     };
-    desc_layout = instance.GetDevice().createDescriptorSetLayoutUnique(desc_layout_ci);
+    auto result = instance.GetDevice().createDescriptorSetLayoutUnique(desc_layout_ci);
+    ASSERT_MSG(result.result == vk::Result::eSuccess,
+               "Failed to create graphics descriptor set layout: {}", vk::to_string(result.result));
+    desc_layout = std::move(result.value);
 }
 
 void GraphicsPipeline::BindResources(const Liverpool::Regs& regs,
diff --git a/src/video_core/renderer_vulkan/vk_instance.cpp b/src/video_core/renderer_vulkan/vk_instance.cpp
index d88d432915..cf5544f01a 100644
--- a/src/video_core/renderer_vulkan/vk_instance.cpp
+++ b/src/video_core/renderer_vulkan/vk_instance.cpp
@@ -23,11 +23,23 @@ namespace Vulkan {
 
 namespace {
 
+std::vector<vk::PhysicalDevice> EnumeratePhysicalDevices(vk::UniqueInstance& instance) {
+    auto devices_result = instance->enumeratePhysicalDevices();
+    ASSERT_MSG(devices_result.result == vk::Result::eSuccess,
+               "Failed to enumerate physical devices: {}", vk::to_string(devices_result.result));
+    return std::move(devices_result.value);
+}
+
 std::vector<std::string> GetSupportedExtensions(vk::PhysicalDevice physical) {
-    const std::vector extensions = physical.enumerateDeviceExtensionProperties();
+    const auto extensions = physical.enumerateDeviceExtensionProperties();
+    if (extensions.result != vk::Result::eSuccess) {
+        LOG_ERROR(Render_Vulkan, "Could not query supported extensions: {}",
+                  vk::to_string(extensions.result));
+        return {};
+    }
     std::vector<std::string> supported_extensions;
-    supported_extensions.reserve(extensions.size());
-    for (const auto& extension : extensions) {
+    supported_extensions.reserve(extensions.value.size());
+    for (const auto& extension : extensions.value) {
         supported_extensions.emplace_back(extension.extensionName.data());
     }
     return supported_extensions;
@@ -52,13 +64,13 @@ std::string GetReadableVersion(u32 version) {
 Instance::Instance(bool enable_validation, bool enable_crash_diagnostic)
     : instance{CreateInstance(Frontend::WindowSystemType::Headless, enable_validation,
                               enable_crash_diagnostic)},
-      physical_devices{instance->enumeratePhysicalDevices()} {}
+      physical_devices{EnumeratePhysicalDevices(instance)} {}
 
 Instance::Instance(Frontend::WindowSDL& window, s32 physical_device_index,
                    bool enable_validation /*= false*/, bool enable_crash_diagnostic /*= false*/)
     : instance{CreateInstance(window.getWindowInfo().type, enable_validation,
                               enable_crash_diagnostic)},
-      physical_devices{instance->enumeratePhysicalDevices()} {
+      physical_devices{EnumeratePhysicalDevices(instance)} {
     if (enable_validation) {
         debug_callback = CreateDebugCallback(*instance);
     }
@@ -385,15 +397,13 @@ bool Instance::CreateDevice() {
         device_chain.unlink<vk::PhysicalDeviceVertexInputDynamicStateFeaturesEXT>();
     }
 
-    try {
-        device = physical_device.createDeviceUnique(device_chain.get());
-    } catch (vk::ExtensionNotPresentError& err) {
-        LOG_CRITICAL(Render_Vulkan, "Some required extensions are not available {}", err.what());
-        return false;
-    } catch (vk::FeatureNotPresentError& err) {
-        LOG_CRITICAL(Render_Vulkan, "Some required features are not available {}", err.what());
+    auto device_result = physical_device.createDeviceUnique(device_chain.get());
+    if (device_result.result != vk::Result::eSuccess) {
+        LOG_CRITICAL(Render_Vulkan, "Failed to create device: {}",
+                     vk::to_string(device_result.result));
         return false;
     }
+    device = std::move(device_result.value);
 
     VULKAN_HPP_DEFAULT_DISPATCHER.init(*device);
 
@@ -401,27 +411,33 @@ bool Instance::CreateDevice() {
     present_queue = device->getQueue(queue_family_index, 0);
 
     if (calibrated_timestamps) {
-        const auto& time_domains = physical_device.getCalibrateableTimeDomainsEXT();
+        const auto& time_domains_result = physical_device.getCalibrateableTimeDomainsEXT();
+        if (time_domains_result.result == vk::Result::eSuccess) {
+            const auto& time_domains = time_domains_result.value;
 #if _WIN64
-        const bool has_host_time_domain =
-            std::find(time_domains.cbegin(), time_domains.cend(),
-                      vk::TimeDomainEXT::eQueryPerformanceCounter) != time_domains.cend();
+            const bool has_host_time_domain =
+                std::find(time_domains.cbegin(), time_domains.cend(),
+                          vk::TimeDomainEXT::eQueryPerformanceCounter) != time_domains.cend();
 #elif __linux__
-        const bool has_host_time_domain =
-            std::find(time_domains.cbegin(), time_domains.cend(),
-                      vk::TimeDomainEXT::eClockMonotonicRaw) != time_domains.cend();
+            const bool has_host_time_domain =
+                std::find(time_domains.cbegin(), time_domains.cend(),
+                          vk::TimeDomainEXT::eClockMonotonicRaw) != time_domains.cend();
 #else
-        // Tracy limitation means only Windows and Linux can use host time domain.
-        // https://github.com/shadps4-emu/tracy/blob/c6d779d78508514102fbe1b8eb28bda10d95bb2a/public/tracy/TracyVulkan.hpp#L384-L389
-        const bool has_host_time_domain = false;
+            // Tracy limitation means only Windows and Linux can use host time domain.
+            // https://github.com/shadps4-emu/tracy/blob/c6d779d78508514102fbe1b8eb28bda10d95bb2a/public/tracy/TracyVulkan.hpp#L384-L389
+            const bool has_host_time_domain = false;
 #endif
-        if (has_host_time_domain) {
-            static constexpr std::string_view context_name{"vk_rasterizer"};
-            profiler_context =
-                TracyVkContextHostCalibrated(*instance, physical_device, *device,
-                                             VULKAN_HPP_DEFAULT_DISPATCHER.vkGetInstanceProcAddr,
-                                             VULKAN_HPP_DEFAULT_DISPATCHER.vkGetDeviceProcAddr);
-            TracyVkContextName(profiler_context, context_name.data(), context_name.size());
+            if (has_host_time_domain) {
+                static constexpr std::string_view context_name{"vk_rasterizer"};
+                profiler_context = TracyVkContextHostCalibrated(
+                    *instance, physical_device, *device,
+                    VULKAN_HPP_DEFAULT_DISPATCHER.vkGetInstanceProcAddr,
+                    VULKAN_HPP_DEFAULT_DISPATCHER.vkGetDeviceProcAddr);
+                TracyVkContextName(profiler_context, context_name.data(), context_name.size());
+            }
+        } else {
+            LOG_WARNING(Render_Vulkan, "Could not query calibrated time domains for profiling: {}",
+                        vk::to_string(time_domains_result.result));
         }
     }
 
@@ -478,7 +494,12 @@ void Instance::CollectToolingInfo() {
         return;
     }
     const auto tools = physical_device.getToolPropertiesEXT();
-    for (const vk::PhysicalDeviceToolProperties& tool : tools) {
+    if (tools.result != vk::Result::eSuccess) {
+        LOG_ERROR(Render_Vulkan, "Could not get Vulkan tool properties: {}",
+                  vk::to_string(tools.result));
+        return;
+    }
+    for (const vk::PhysicalDeviceToolProperties& tool : tools.value) {
         const std::string_view name = tool.name;
         LOG_INFO(Render_Vulkan, "Attached debugging tool: {}", name);
         has_renderdoc = has_renderdoc || name == "RenderDoc";
diff --git a/src/video_core/renderer_vulkan/vk_master_semaphore.cpp b/src/video_core/renderer_vulkan/vk_master_semaphore.cpp
index 753f2bbdf5..0787d8ff20 100644
--- a/src/video_core/renderer_vulkan/vk_master_semaphore.cpp
+++ b/src/video_core/renderer_vulkan/vk_master_semaphore.cpp
@@ -5,6 +5,8 @@
 #include "video_core/renderer_vulkan/vk_instance.h"
 #include "video_core/renderer_vulkan/vk_master_semaphore.h"
 
+#include "common/assert.h"
+
 namespace Vulkan {
 
 constexpr u64 WAIT_TIMEOUT = std::numeric_limits<u64>::max();
@@ -17,7 +19,10 @@ MasterSemaphore::MasterSemaphore(const Instance& instance_) : instance{instance_
             .initialValue = 0,
         },
     };
-    semaphore = instance.GetDevice().createSemaphoreUnique(semaphore_chain.get());
+    auto result = instance.GetDevice().createSemaphoreUnique(semaphore_chain.get());
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to create master semaphore: {}",
+               vk::to_string(result.result));
+    semaphore = std::move(result.value);
 }
 
 MasterSemaphore::~MasterSemaphore() = default;
@@ -27,7 +32,11 @@ void MasterSemaphore::Refresh() {
     u64 counter{};
     do {
         this_tick = gpu_tick.load(std::memory_order_acquire);
-        counter = instance.GetDevice().getSemaphoreCounterValue(*semaphore);
+        auto counter_result = instance.GetDevice().getSemaphoreCounterValue(*semaphore);
+        ASSERT_MSG(counter_result.result == vk::Result::eSuccess,
+                   "Failed to get master semaphore value: {}",
+                   vk::to_string(counter_result.result));
+        counter = counter_result.value;
         if (counter < this_tick) {
             return;
         }
diff --git a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
index 7f6079a5c7..73a115b4a6 100644
--- a/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
+++ b/src/video_core/renderer_vulkan/vk_pipeline_cache.cpp
@@ -136,7 +136,10 @@ PipelineCache::PipelineCache(const Instance& instance_, Scheduler& scheduler_,
         .subgroup_size = instance.SubgroupSize(),
         .support_explicit_workgroup_layout = true,
     };
-    pipeline_cache = instance.GetDevice().createPipelineCacheUnique({});
+    auto cache_result = instance.GetDevice().createPipelineCacheUnique({});
+    ASSERT_MSG(cache_result.result == vk::Result::eSuccess, "Failed to create pipeline cache: {}",
+               vk::to_string(cache_result.result));
+    pipeline_cache = std::move(cache_result.value);
 }
 
 PipelineCache::~PipelineCache() = default;
diff --git a/src/video_core/renderer_vulkan/vk_platform.cpp b/src/video_core/renderer_vulkan/vk_platform.cpp
index feadda96c8..f85644a53e 100644
--- a/src/video_core/renderer_vulkan/vk_platform.cpp
+++ b/src/video_core/renderer_vulkan/vk_platform.cpp
@@ -135,11 +135,13 @@ vk::SurfaceKHR CreateSurface(vk::Instance instance, const Frontend::WindowSDL& e
 
 std::vector<const char*> GetInstanceExtensions(Frontend::WindowSystemType window_type,
                                                bool enable_debug_utils) {
-    const auto properties = vk::enumerateInstanceExtensionProperties();
-    if (properties.empty()) {
-        LOG_ERROR(Render_Vulkan, "Failed to query extension properties");
+    const auto properties_result = vk::enumerateInstanceExtensionProperties();
+    if (properties_result.result != vk::Result::eSuccess || properties_result.value.empty()) {
+        LOG_ERROR(Render_Vulkan, "Failed to query extension properties: {}",
+                  vk::to_string(properties_result.result));
         return {};
     }
+    const auto& properties = properties_result.value;
 
     // Add the windowing system specific extension
     std::vector<const char*> extensions;
@@ -208,14 +210,16 @@ vk::UniqueInstance CreateInstance(Frontend::WindowSystemType window_type, bool e
 #endif
     VULKAN_HPP_DEFAULT_DISPATCHER.init(vkGetInstanceProcAddr);
 
-    const u32 available_version = VULKAN_HPP_DEFAULT_DISPATCHER.vkEnumerateInstanceVersion
-                                      ? vk::enumerateInstanceVersion()
-                                      : VK_API_VERSION_1_0;
-
-    ASSERT_MSG(available_version >= TargetVulkanApiVersion,
+    const auto available_version = VULKAN_HPP_DEFAULT_DISPATCHER.vkEnumerateInstanceVersion
+                                       ? vk::enumerateInstanceVersion()
+                                       : vk::ResultValue(vk::Result::eSuccess, VK_API_VERSION_1_0);
+    ASSERT_MSG(available_version.result == vk::Result::eSuccess,
+               "Failed to query Vulkan API version: {}", vk::to_string(available_version.result));
+    ASSERT_MSG(available_version.value >= TargetVulkanApiVersion,
                "Vulkan {}.{} is required, but only {}.{} is supported by instance!",
                VK_VERSION_MAJOR(TargetVulkanApiVersion), VK_VERSION_MINOR(TargetVulkanApiVersion),
-               VK_VERSION_MAJOR(available_version), VK_VERSION_MINOR(available_version));
+               VK_VERSION_MAJOR(available_version.value),
+               VK_VERSION_MINOR(available_version.value));
 
     const auto extensions = GetInstanceExtensions(window_type, true);
 
@@ -224,7 +228,7 @@ vk::UniqueInstance CreateInstance(Frontend::WindowSystemType window_type, bool e
         .applicationVersion = VK_MAKE_VERSION(1, 0, 0),
         .pEngineName = "shadPS4 Vulkan",
         .engineVersion = VK_MAKE_VERSION(1, 0, 0),
-        .apiVersion = available_version,
+        .apiVersion = available_version.value,
     };
 
     u32 num_layers = 0;
@@ -342,11 +346,13 @@ vk::UniqueInstance CreateInstance(Frontend::WindowSystemType window_type, bool e
         },
     };
 
-    auto instance = vk::createInstanceUnique(instance_ci_chain.get());
+    auto instance_result = vk::createInstanceUnique(instance_ci_chain.get());
+    ASSERT_MSG(instance_result.result == vk::Result::eSuccess, "Failed to create instance: {}",
+               vk::to_string(instance_result.result));
 
-    VULKAN_HPP_DEFAULT_DISPATCHER.init(*instance);
+    VULKAN_HPP_DEFAULT_DISPATCHER.init(*instance_result.value);
 
-    return instance;
+    return std::move(instance_result.value);
 }
 
 vk::UniqueDebugUtilsMessengerEXT CreateDebugCallback(vk::Instance instance) {
@@ -360,7 +366,10 @@ vk::UniqueDebugUtilsMessengerEXT CreateDebugCallback(vk::Instance instance) {
                        vk::DebugUtilsMessageTypeFlagBitsEXT::ePerformance,
         .pfnUserCallback = DebugUtilsCallback,
     };
-    return instance.createDebugUtilsMessengerEXTUnique(msg_ci);
+    auto result = instance.createDebugUtilsMessengerEXTUnique(msg_ci);
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to create debug callback: {}",
+               vk::to_string(result.result));
+    return std::move(result.value);
 }
 
 } // namespace Vulkan
diff --git a/src/video_core/renderer_vulkan/vk_platform.h b/src/video_core/renderer_vulkan/vk_platform.h
index e38bd2fef5..6b425b6d83 100644
--- a/src/video_core/renderer_vulkan/vk_platform.h
+++ b/src/video_core/renderer_vulkan/vk_platform.h
@@ -7,6 +7,7 @@
 #include <variant>
 #include <fmt/format.h>
 
+#include "common/logging/log.h"
 #include "common/types.h"
 #include "video_core/renderer_vulkan/vk_common.h"
 
@@ -36,7 +37,10 @@ void SetObjectName(vk::Device device, const HandleType& handle, std::string_view
         .objectHandle = reinterpret_cast<u64>(static_cast<typename HandleType::NativeType>(handle)),
         .pObjectName = debug_name.data(),
     };
-    device.setDebugUtilsObjectNameEXT(name_info);
+    auto result = device.setDebugUtilsObjectNameEXT(name_info);
+    if (result != vk::Result::eSuccess) {
+        LOG_DEBUG(Render_Vulkan, "Could not set object debug name: {}", vk::to_string(result));
+    }
 }
 
 template <VulkanHandleType HandleType, typename... Args>
diff --git a/src/video_core/renderer_vulkan/vk_rasterizer.cpp b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
index 23f60da13f..debedbd234 100644
--- a/src/video_core/renderer_vulkan/vk_rasterizer.cpp
+++ b/src/video_core/renderer_vulkan/vk_rasterizer.cpp
@@ -24,7 +24,6 @@ Rasterizer::Rasterizer(const Instance& instance_, Scheduler& scheduler_,
         liverpool->BindRasterizer(this);
     }
     memory->SetRasterizer(this);
-    wfi_event = instance.GetDevice().createEventUnique({});
 }
 
 Rasterizer::~Rasterizer() = default;
diff --git a/src/video_core/renderer_vulkan/vk_rasterizer.h b/src/video_core/renderer_vulkan/vk_rasterizer.h
index 5aa90c5ccc..9056bd921c 100644
--- a/src/video_core/renderer_vulkan/vk_rasterizer.h
+++ b/src/video_core/renderer_vulkan/vk_rasterizer.h
@@ -67,7 +67,6 @@ class Rasterizer {
     AmdGpu::Liverpool* liverpool;
     Core::MemoryManager* memory;
     PipelineCache pipeline_cache;
-    vk::UniqueEvent wfi_event;
 };
 
 } // namespace Vulkan
diff --git a/src/video_core/renderer_vulkan/vk_resource_pool.cpp b/src/video_core/renderer_vulkan/vk_resource_pool.cpp
index a5ee22c252..ab6f405d1e 100644
--- a/src/video_core/renderer_vulkan/vk_resource_pool.cpp
+++ b/src/video_core/renderer_vulkan/vk_resource_pool.cpp
@@ -69,7 +69,10 @@ CommandPool::CommandPool(const Instance& instance, MasterSemaphore* master_semap
         .queueFamilyIndex = instance.GetGraphicsQueueFamilyIndex(),
     };
     const vk::Device device = instance.GetDevice();
-    cmd_pool = device.createCommandPoolUnique(pool_create_info);
+    auto result = device.createCommandPoolUnique(pool_create_info);
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to create command pool: {}",
+               vk::to_string(result.result));
+    cmd_pool = std::move(result.value);
     if (instance.HasDebuggingToolAttached()) {
         SetObjectName(device, *cmd_pool, "CommandPool");
     }
@@ -182,7 +185,10 @@ void DescriptorHeap::CreateDescriptorPool() {
         .poolSizeCount = static_cast<u32>(pool_sizes.size()),
         .pPoolSizes = pool_sizes.data(),
     };
-    curr_pool = device.createDescriptorPool(pool_info);
+    auto result = device.createDescriptorPool(pool_info);
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to create descriptor pool: {}",
+               vk::to_string(result.result));
+    curr_pool = result.value;
 }
 
 } // namespace Vulkan
diff --git a/src/video_core/renderer_vulkan/vk_scheduler.cpp b/src/video_core/renderer_vulkan/vk_scheduler.cpp
index b99dfdbb46..95756aa549 100644
--- a/src/video_core/renderer_vulkan/vk_scheduler.cpp
+++ b/src/video_core/renderer_vulkan/vk_scheduler.cpp
@@ -141,7 +141,9 @@ void Scheduler::AllocateWorkerCommandBuffers() {
     };
 
     current_cmdbuf = command_pool.Commit();
-    current_cmdbuf.begin(begin_info);
+    auto begin_result = current_cmdbuf.begin(begin_info);
+    ASSERT_MSG(begin_result == vk::Result::eSuccess, "Failed to begin command buffer: {}",
+               vk::to_string(begin_result));
 
     auto* profiler_ctx = instance.GetProfilerContext();
     if (profiler_ctx) {
@@ -162,7 +164,9 @@ void Scheduler::SubmitExecution(SubmitInfo& info) {
     }
 
     EndRendering();
-    current_cmdbuf.end();
+    auto end_result = current_cmdbuf.end();
+    ASSERT_MSG(end_result == vk::Result::eSuccess, "Failed to end command buffer: {}",
+               vk::to_string(end_result));
 
     const vk::Semaphore timeline = master_semaphore.Handle();
     info.AddSignal(timeline, signal_value);
@@ -190,12 +194,9 @@ void Scheduler::SubmitExecution(SubmitInfo& info) {
         .pSignalSemaphores = info.signal_semas.data(),
     };
 
-    try {
-        ImGui::Core::TextureManager::Submit();
-        instance.GetGraphicsQueue().submit(submit_info, info.fence);
-    } catch (vk::DeviceLostError& err) {
-        UNREACHABLE_MSG("Device lost during submit: {}", err.what());
-    }
+    ImGui::Core::TextureManager::Submit();
+    auto submit_result = instance.GetGraphicsQueue().submit(submit_info, info.fence);
+    ASSERT_MSG(submit_result != vk::Result::eErrorDeviceLost, "Device lost during submit");
 
     master_semaphore.Refresh();
     AllocateWorkerCommandBuffers();
diff --git a/src/video_core/renderer_vulkan/vk_shader_util.cpp b/src/video_core/renderer_vulkan/vk_shader_util.cpp
index 687760110c..9985014053 100644
--- a/src/video_core/renderer_vulkan/vk_shader_util.cpp
+++ b/src/video_core/renderer_vulkan/vk_shader_util.cpp
@@ -218,13 +218,10 @@ vk::ShaderModule CompileSPV(std::span<const u32> code, vk::Device device) {
         .pCode = code.data(),
     };
 
-    try {
-        return device.createShaderModule(shader_info);
-    } catch (vk::SystemError& err) {
-        UNREACHABLE_MSG("{}", err.what());
-    }
-
-    return {};
+    auto result = device.createShaderModule(shader_info);
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to compile SPIR-V shader: {}",
+               vk::to_string(result.result));
+    return result.value;
 }
 
 } // namespace Vulkan
diff --git a/src/video_core/renderer_vulkan/vk_swapchain.cpp b/src/video_core/renderer_vulkan/vk_swapchain.cpp
index dcc19bf3b1..9360d69cdc 100644
--- a/src/video_core/renderer_vulkan/vk_swapchain.cpp
+++ b/src/video_core/renderer_vulkan/vk_swapchain.cpp
@@ -39,11 +39,14 @@ void Swapchain::Create(u32 width_, u32 height_, vk::SurfaceKHR surface_) {
 
     const auto modes = instance.GetPhysicalDevice().getSurfacePresentModesKHR(surface);
     const auto find_mode = [&modes](vk::PresentModeKHR requested) {
+        if (modes.result != vk::Result::eSuccess) {
+            return false;
+        }
         const auto it =
-            std::find_if(modes.begin(), modes.end(),
+            std::find_if(modes.value.begin(), modes.value.end(),
                          [&requested](vk::PresentModeKHR mode) { return mode == requested; });
 
-        return it != modes.end();
+        return it != modes.value.end();
     };
     const bool has_mailbox = find_mode(vk::PresentModeKHR::eMailbox);
 
@@ -70,12 +73,10 @@ void Swapchain::Create(u32 width_, u32 height_, vk::SurfaceKHR surface_) {
         .oldSwapchain = nullptr,
     };
 
-    try {
-        swapchain = instance.GetDevice().createSwapchainKHR(swapchain_info);
-    } catch (vk::SystemError& err) {
-        LOG_CRITICAL(Render_Vulkan, "{}", err.what());
-        UNREACHABLE();
-    }
+    auto swapchain_result = instance.GetDevice().createSwapchainKHR(swapchain_info);
+    ASSERT_MSG(swapchain_result.result == vk::Result::eSuccess, "Failed to create swapchain: {}",
+               vk::to_string(swapchain_result.result));
+    swapchain = std::move(swapchain_result.value);
 
     SetupImages();
     RefreshSemaphores();
@@ -119,20 +120,22 @@ void Swapchain::Present() {
         .pImageIndices = &image_index,
     };
 
-    try {
-        [[maybe_unused]] vk::Result result = instance.GetPresentQueue().presentKHR(present_info);
-    } catch (vk::OutOfDateKHRError&) {
+    auto result = instance.GetPresentQueue().presentKHR(present_info);
+    if (result == vk::Result::eErrorOutOfDateKHR) {
         needs_recreation = true;
-    } catch (const vk::SystemError& err) {
-        LOG_CRITICAL(Render_Vulkan, "Swapchain presentation failed {}", err.what());
-        UNREACHABLE();
+    } else {
+        ASSERT_MSG(result == vk::Result::eSuccess, "Swapchain presentation failed: {}",
+                   vk::to_string(result));
     }
 
     frame_index = (frame_index + 1) % image_count;
 }
 
 void Swapchain::FindPresentFormat() {
-    const auto formats = instance.GetPhysicalDevice().getSurfaceFormatsKHR(surface);
+    const auto formats_result = instance.GetPhysicalDevice().getSurfaceFormatsKHR(surface);
+    ASSERT_MSG(formats_result.result == vk::Result::eSuccess, "Failed to query surface formats: {}",
+               vk::to_string(formats_result.result));
+    const auto& formats = formats_result.value;
 
     // If there is a single undefined surface format, the device doesn't care, so we'll just use
     // RGBA sRGB.
@@ -158,8 +161,12 @@ void Swapchain::FindPresentFormat() {
 }
 
 void Swapchain::SetSurfaceProperties() {
-    const vk::SurfaceCapabilitiesKHR capabilities =
+    const auto capabilities_result =
         instance.GetPhysicalDevice().getSurfaceCapabilitiesKHR(surface);
+    ASSERT_MSG(capabilities_result.result == vk::Result::eSuccess,
+               "Failed to query surface capabilities: {}",
+               vk::to_string(capabilities_result.result));
+    const auto& capabilities = capabilities_result.value;
 
     extent = capabilities.currentExtent;
     if (capabilities.currentExtent.width == std::numeric_limits<u32>::max()) {
@@ -207,10 +214,16 @@ void Swapchain::RefreshSemaphores() {
     present_ready.resize(image_count);
 
     for (vk::Semaphore& semaphore : image_acquired) {
-        semaphore = device.createSemaphore({});
+        auto result = device.createSemaphore({});
+        ASSERT_MSG(result.result == vk::Result::eSuccess,
+                   "Failed to create image acquired semaphore: {}", vk::to_string(result.result));
+        semaphore = result.value;
     }
     for (vk::Semaphore& semaphore : present_ready) {
-        semaphore = device.createSemaphore({});
+        auto result = device.createSemaphore({});
+        ASSERT_MSG(result.result == vk::Result::eSuccess,
+                   "Failed to create present ready semaphore: {}", vk::to_string(result.result));
+        semaphore = result.value;
     }
 
     if (instance.HasDebuggingToolAttached()) {
@@ -223,7 +236,10 @@ void Swapchain::RefreshSemaphores() {
 
 void Swapchain::SetupImages() {
     vk::Device device = instance.GetDevice();
-    images = device.getSwapchainImagesKHR(swapchain);
+    auto images_result = device.getSwapchainImagesKHR(swapchain);
+    ASSERT_MSG(images_result.result == vk::Result::eSuccess,
+               "Failed to create swapchain images: {}", vk::to_string(images_result.result));
+    images = std::move(images_result.value);
     image_count = static_cast<u32>(images.size());
 
     if (instance.HasDebuggingToolAttached()) {
diff --git a/src/video_core/texture_cache/image.cpp b/src/video_core/texture_cache/image.cpp
index 9e8c38f0de..c242015a54 100644
--- a/src/video_core/texture_cache/image.cpp
+++ b/src/video_core/texture_cache/image.cpp
@@ -1,7 +1,6 @@
 // SPDX-FileCopyrightText: Copyright 2024 shadPS4 Emulator Project
 // SPDX-License-Identifier: GPL-2.0-or-later
 
-#define VULKAN_HPP_NO_EXCEPTIONS
 #include "common/assert.h"
 #include "video_core/renderer_vulkan/liverpool_to_vk.h"
 #include "video_core/renderer_vulkan/vk_instance.h"
diff --git a/src/video_core/texture_cache/image_view.cpp b/src/video_core/texture_cache/image_view.cpp
index f94c1a37b6..7457986fd6 100644
--- a/src/video_core/texture_cache/image_view.cpp
+++ b/src/video_core/texture_cache/image_view.cpp
@@ -152,7 +152,10 @@ ImageView::ImageView(const Vulkan::Instance& instance, const ImageViewInfo& info
             .layerCount = info.range.extent.layers - info.range.base.layer,
         },
     };
-    image_view = instance.GetDevice().createImageViewUnique(image_view_ci);
+    auto result = instance.GetDevice().createImageViewUnique(image_view_ci);
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to create image view: {}",
+               vk::to_string(result.result));
+    image_view = std::move(result.value);
 }
 
 ImageView::~ImageView() = default;
diff --git a/src/video_core/texture_cache/sampler.cpp b/src/video_core/texture_cache/sampler.cpp
index 19c92712cb..72cb727a2e 100644
--- a/src/video_core/texture_cache/sampler.cpp
+++ b/src/video_core/texture_cache/sampler.cpp
@@ -24,7 +24,10 @@ Sampler::Sampler(const Vulkan::Instance& instance, const AmdGpu::Sampler& sample
         .borderColor = LiverpoolToVK::BorderColor(sampler.border_color_type),
         .unnormalizedCoordinates = bool(sampler.force_unnormalized),
     };
-    handle = instance.GetDevice().createSamplerUnique(sampler_ci);
+    auto result = instance.GetDevice().createSamplerUnique(sampler_ci);
+    ASSERT_MSG(result.result == vk::Result::eSuccess, "Failed to create sampler: {}",
+               vk::to_string(result.result));
+    handle = std::move(result.value);
 }
 
 Sampler::~Sampler() = default;
diff --git a/src/video_core/texture_cache/tile_manager.cpp b/src/video_core/texture_cache/tile_manager.cpp
index 7e06291e73..7f9b078b25 100644
--- a/src/video_core/texture_cache/tile_manager.cpp
+++ b/src/video_core/texture_cache/tile_manager.cpp
@@ -298,8 +298,11 @@ TileManager::TileManager(const Vulkan::Instance& instance, Vulkan::Scheduler& sc
             .bindingCount = static_cast<u32>(bindings.size()),
             .pBindings = bindings.data(),
         };
-        static auto desc_layout =
+        static auto desc_layout_result =
             instance.GetDevice().createDescriptorSetLayoutUnique(desc_layout_ci);
+        ASSERT_MSG(desc_layout_result.result == vk::Result::eSuccess,
+                   "Failed to create descriptor set layout: {}",
+                   vk::to_string(desc_layout_result.result));
 
         const vk::PushConstantRange push_constants = {
             .stageFlags = vk::ShaderStageFlagBits::eCompute,
@@ -307,14 +310,17 @@ TileManager::TileManager(const Vulkan::Instance& instance, Vulkan::Scheduler& sc
             .size = sizeof(DetilerParams),
         };
 
-        const vk::DescriptorSetLayout set_layout = *desc_layout;
+        const vk::DescriptorSetLayout set_layout = *desc_layout_result.value;
         const vk::PipelineLayoutCreateInfo layout_info = {
             .setLayoutCount = 1U,
             .pSetLayouts = &set_layout,
             .pushConstantRangeCount = 1,
             .pPushConstantRanges = &push_constants,
         };
-        ctx.pl_layout = instance.GetDevice().createPipelineLayoutUnique(layout_info);
+        auto layout_result = instance.GetDevice().createPipelineLayoutUnique(layout_info);
+        ASSERT_MSG(layout_result.result == vk::Result::eSuccess,
+                   "Failed to create pipeline layout: {}", vk::to_string(layout_result.result));
+        ctx.pl_layout = std::move(layout_result.value);
 
         const vk::ComputePipelineCreateInfo compute_pipeline_ci = {
             .stage = shader_ci,