diff --git a/.github/workflows/freeze_requirements.yml b/.github/workflows/freeze_requirements.yml
new file mode 100644
index 000000000..de49439f5
--- /dev/null
+++ b/.github/workflows/freeze_requirements.yml
@@ -0,0 +1,32 @@
+name : Freeze release requirements
+
+on: 
+  push:
+    tags:
+      - '*'
+
+jobs:
+  freeze_requirements:
+    runs-on: ubuntu-latest
+    steps:
+      - 
+        name: Checkout scilpy
+        uses: actions/checkout@v3
+      -
+        name: Install python
+        uses: actions/setup-python@v4
+        with:
+          python-version-file: '.python-version'
+          cache: 'pip'
+      -
+        name: Freeze requirements
+        id: requirements-freezer
+        run: |
+          pip install pip-tools
+          pip-compile --no-upgrade --allow-unsafe -o requirements.${{ github.ref_name }}.frozen
+          echo "requirements=$PWD/requirements.${{ github.ref_name }}.frozen" >> $GITHUB_OUTPUT
+      -
+        name: Upload frozen requirements to release
+        uses: softprops/action-gh-release@v1
+        with:
+          files : ${{ steps.requirements-freezer.outputs.requirements }}
diff --git a/.python-version b/.python-version
new file mode 100644
index 000000000..7c7a975f4
--- /dev/null
+++ b/.python-version
@@ -0,0 +1 @@
+3.10
\ No newline at end of file
diff --git a/requirements.txt b/requirements.txt
index 9c3fcdc13..d9871f653 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -30,7 +30,6 @@ pytest-mock==3.10.*
 python-dateutil==2.8.*
 pytz==2022.6.*
 requests==2.28.*
-setuptools==64.0.*
 scikit-learn==1.2.*
 scipy==1.9.*
 six==1.16.*
diff --git a/scilpy/version.py b/scilpy/version.py
index edba41e44..d72f19157 100644
--- a/scilpy/version.py
+++ b/scilpy/version.py
@@ -25,6 +25,24 @@
                "Programming Language :: Python",
                "Topic :: Scientific/Engineering"]
 
+PYTHON_VERSION = ""
+with open('.python-version') as f:
+    py_version = f.readline().strip("\n").split(".")
+    py_major = py_version[0]
+    py_minor = py_version[1]
+    py_micro = "*"
+    py_extra = None
+    if len(py_version) > 2:
+        py_micro = py_version[2]
+    if len(py_version) > 3:
+        py_extra = py_version[3]
+
+    PYTHON_VERSION = ".".join([py_major, py_minor, py_micro])
+    if py_extra:
+        PYTHON_VERSION = ".".join([PYTHON_VERSION, py_extra])
+
+    PYTHON_VERSION = "".join(["==", PYTHON_VERSION])
+
 # Description should be a one-liner:
 description = "Scilpy: diffusion MRI tools and utilities"
 # Long description will go up on the pypi page
diff --git a/setup.py b/setup.py
index bcaba2b36..993a250ff 100644
--- a/setup.py
+++ b/setup.py
@@ -66,6 +66,7 @@ def run(self):
             packages=find_packages(),
             cmdclass={'build_ext': CustomBuildExtCommand},
             ext_modules=get_extensions(),
+            python_requires=PYTHON_VERSION,
             setup_requires=['cython', 'numpy'],
             install_requires=external_dependencies,
             entry_points={