diff --git a/bin/windows/contrib/4.2/GenomeInfoDbData_1.2.11.zip b/bin/windows/contrib/4.2/GenomeInfoDbData_1.2.12.zip
similarity index 59%
rename from bin/windows/contrib/4.2/GenomeInfoDbData_1.2.11.zip
rename to bin/windows/contrib/4.2/GenomeInfoDbData_1.2.12.zip
index 227980cd..4ec26dd4 100644
Binary files a/bin/windows/contrib/4.2/GenomeInfoDbData_1.2.11.zip and b/bin/windows/contrib/4.2/GenomeInfoDbData_1.2.12.zip differ
diff --git a/bin/windows/contrib/4.2/Hmisc_5.1-1.zip b/bin/windows/contrib/4.2/Hmisc_5.1-1.zip
deleted file mode 100644
index 25529f57..00000000
Binary files a/bin/windows/contrib/4.2/Hmisc_5.1-1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/Hmisc_5.1-2.zip b/bin/windows/contrib/4.2/Hmisc_5.1-2.zip
new file mode 100644
index 00000000..af019dce
Binary files /dev/null and b/bin/windows/contrib/4.2/Hmisc_5.1-2.zip differ
diff --git a/bin/windows/contrib/4.2/InterpretMSSpectrum_1.3.3.zip b/bin/windows/contrib/4.2/InterpretMSSpectrum_1.3.3.zip
index f36bc8ae..135aae8a 100644
Binary files a/bin/windows/contrib/4.2/InterpretMSSpectrum_1.3.3.zip and b/bin/windows/contrib/4.2/InterpretMSSpectrum_1.3.3.zip differ
diff --git a/bin/windows/contrib/4.2/MS2Tox_0.3.2.zip b/bin/windows/contrib/4.2/MS2Tox_0.3.2.zip
index 85175fcb..bd5edd11 100644
Binary files a/bin/windows/contrib/4.2/MS2Tox_0.3.2.zip and b/bin/windows/contrib/4.2/MS2Tox_0.3.2.zip differ
diff --git a/bin/windows/contrib/4.2/PACKAGES b/bin/windows/contrib/4.2/PACKAGES
index 0b016a2c..91ca4732 100644
--- a/bin/windows/contrib/4.2/PACKAGES
+++ b/bin/windows/contrib/4.2/PACKAGES
@@ -121,7 +121,7 @@ Suggests: covr, crayon, pillar (>= 1.2.1), testthat
 License: MIT + file LICENSE
 
 Package: bookdown
-Version: 0.37
+Version: 0.38
 Depends: R (>= 3.5.0)
 Imports: htmltools (>= 0.3.6), knitr (>= 1.38), rmarkdown (>= 2.14),
         jquerylib, xfun (>= 0.39), tinytex (>= 0.12), yaml (>= 2.1.19)
@@ -152,13 +152,13 @@ Suggests: AER, AUC, bbmle, betareg, biglm, binGroup, boot, btergm (>=
 License: MIT + file LICENSE
 
 Package: bslib
-Version: 0.6.1
+Version: 0.7.0
 Depends: R (>= 2.10)
-Imports: base64enc, cachem, grDevices, htmltools (>= 0.5.7), jquerylib
-        (>= 0.1.3), jsonlite, lifecycle, memoise (>= 2.0.1), mime,
-        rlang, sass (>= 0.4.0)
-Suggests: bsicons, curl, fontawesome, ggplot2, knitr, magrittr,
-        rappdirs, rmarkdown (>= 2.7), shiny (>= 1.8.0), testthat,
+Imports: base64enc, cachem, fastmap (>= 1.1.1), grDevices, htmltools
+        (>= 0.5.8), jquerylib (>= 0.1.3), jsonlite, lifecycle, memoise
+        (>= 2.0.1), mime, rlang, sass (>= 0.4.9)
+Suggests: bsicons, curl, fontawesome, future, ggplot2, knitr, magrittr,
+        rappdirs, rmarkdown (>= 2.7), shiny (>= 1.8.1), testthat,
         thematic, withr
 License: MIT + file LICENSE
 
@@ -181,11 +181,11 @@ Depends: R (>= 3.5.0), MASS
 License: GPL-2
 
 Package: callr
-Version: 3.7.5
+Version: 3.7.6
 Depends: R (>= 3.4)
 Imports: processx (>= 3.6.1), R6, utils
-Suggests: asciicast (>= 2.3.1), cli (>= 1.1.0), covr, mockery, ps,
-        rprojroot, spelling, testthat (>= 3.2.0), withr (>= 2.3.0)
+Suggests: asciicast (>= 2.3.1), cli (>= 1.1.0), mockery, ps, rprojroot,
+        spelling, testthat (>= 3.2.0), withr (>= 2.3.0)
 License: MIT + file LICENSE
 
 Package: CAMERA
@@ -386,15 +386,15 @@ Suggests: shiny, ggplot2, testthat (>= 2.1.0), sass, bslib
 License: MIT + file LICENSE
 
 Package: curl
-Version: 5.2.0
+Version: 5.2.1
 Depends: R (>= 3.0.0)
 Suggests: spelling, testthat (>= 1.0.0), knitr, jsonlite, later,
-        rmarkdown, magrittr, httpuv (>= 1.4.4), webutils
+        rmarkdown, httpuv (>= 1.4.4), webutils
 License: MIT + file LICENSE
 Archs: x64
 
 Package: data.table
-Version: 1.15.0
+Version: 1.15.2
 Depends: R (>= 3.1.0)
 Imports: methods
 Suggests: bit64 (>= 4.0.0), bit (>= 4.0.4), R.utils, xts, zoo (>=
@@ -422,17 +422,17 @@ Suggests: arrow, blob, covr, DBItest, dbplyr, downlit, dplyr, glue,
 License: LGPL (>= 2.1)
 
 Package: dbplyr
-Version: 2.4.0
+Version: 2.5.0
 Depends: R (>= 3.6)
 Imports: blob (>= 1.2.0), cli (>= 3.6.1), DBI (>= 1.1.3), dplyr (>=
         1.1.2), glue (>= 1.6.2), lifecycle (>= 1.0.3), magrittr,
         methods, pillar (>= 1.9.0), purrr (>= 1.0.1), R6 (>= 2.2.2),
         rlang (>= 1.1.1), tibble (>= 3.2.1), tidyr (>= 1.3.0),
-        tidyselect (>= 1.2.0), utils, vctrs (>= 0.6.3), withr (>=
+        tidyselect (>= 1.2.1), utils, vctrs (>= 0.6.3), withr (>=
         2.5.0)
-Suggests: bit64, covr, knitr, Lahman, nycflights13, odbc, RMariaDB (>=
-        1.2.2), rmarkdown, RPostgres (>= 1.4.5), RPostgreSQL, RSQLite
-        (>= 2.3.1), testthat (>= 3.1.10)
+Suggests: bit64, covr, knitr, Lahman, nycflights13, odbc (>= 1.4.2),
+        RMariaDB (>= 1.2.2), rmarkdown, RPostgres (>= 1.4.5),
+        RPostgreSQL, RSQLite (>= 2.3.1), testthat (>= 3.1.10)
 License: MIT + file LICENSE
 
 Package: dbscan
@@ -482,7 +482,7 @@ Imports: stats, graphics
 License: GPL (>= 2)
 
 Package: digest
-Version: 0.6.34
+Version: 0.6.35
 Depends: R (>= 3.3.0)
 Imports: utils
 Suggests: tinytest, simplermarkdown
@@ -728,14 +728,14 @@ Depends: R (>= 2.8.0)
 License: LGPL-3
 
 Package: future.apply
-Version: 1.11.1
+Version: 1.11.2
 Depends: R (>= 3.2.0), future (>= 1.28.0)
 Imports: globals (>= 0.16.1), parallel, utils
 Suggests: datasets, stats, tools, listenv (>= 0.8.0), R.rsp, markdown
 License: GPL (>= 2)
 
 Package: future
-Version: 1.33.1
+Version: 1.33.2
 Imports: digest, globals (>= 0.16.1), listenv (>= 0.8.0), parallel,
         parallelly (>= 1.34.0), utils
 Suggests: methods, RhpcBLASctl, R.rsp, markdown
@@ -786,7 +786,7 @@ Suggests: GenomicRanges, Rsamtools, GenomicAlignments, GenomicFeatures,
 License: Artistic-2.0
 
 Package: GenomeInfoDbData
-Version: 1.2.11
+Version: 1.2.12
 Depends: R (>= 3.3)
 License: Artistic-2.0
 
@@ -821,15 +821,15 @@ License: BSD 2-clause License + file LICENSE
 Archs: x64
 
 Package: ggplot2
-Version: 3.4.4
-Depends: R (>= 3.3)
+Version: 3.5.0
+Depends: R (>= 3.5)
 Imports: cli, glue, grDevices, grid, gtable (>= 0.1.1), isoband,
         lifecycle (> 1.0.1), MASS, mgcv, rlang (>= 1.1.0), scales (>=
-        1.2.0), stats, tibble, vctrs (>= 0.5.0), withr (>= 2.5.0)
-Suggests: covr, dplyr, ggplot2movies, hexbin, Hmisc, knitr, lattice,
-        mapproj, maps, multcomp, munsell, nlme, profvis, quantreg,
-        ragg, RColorBrewer, rmarkdown, rpart, sf (>= 0.7-3), svglite
-        (>= 1.2.0.9001), testthat (>= 3.1.2), vdiffr (>= 1.0.0), xml2
+        1.3.0), stats, tibble, vctrs (>= 0.5.0), withr (>= 2.5.0)
+Suggests: covr, dplyr, ggplot2movies, hexbin, Hmisc, knitr, mapproj,
+        maps, multcomp, munsell, nlme, profvis, quantreg, ragg (>=
+        1.2.6), RColorBrewer, rmarkdown, rpart, sf (>= 0.7-3), svglite
+        (>= 2.1.2), testthat (>= 3.1.2), vdiffr (>= 1.0.6), xml2
 Enhances: sp
 License: MIT + file LICENSE
 
@@ -853,7 +853,7 @@ Suggests: testthat (>= 1.0.0), knitr, markdown, GetoptLong
 License: MIT + file LICENSE
 
 Package: globals
-Version: 0.16.2
+Version: 0.16.3
 Depends: R (>= 3.1.2)
 Imports: codetools
 License: LGPL (>= 2.1)
@@ -972,7 +972,8 @@ Suggests: knitr, markdown, testit
 License: GPL
 
 Package: Hmisc
-Version: 5.1-1
+Version: 5.1-2
+Depends: R (>= 4.1.0)
 Imports: methods, ggplot2, cluster, rpart, nnet, foreign, gtable, grid,
         gridExtra, data.table, htmlTable (>= 1.11.0), viridis,
         htmltools, base64enc, colorspace, rmarkdown, knitr, Formula
@@ -980,7 +981,7 @@ Suggests: survival, qreport, acepack, chron, rms, mice, rstudioapi,
         tables, plotly (>= 4.5.6), rlang, plyr, VGAM, leaps, pcaPP,
         digest, parallel, polspline, abind, kableExtra, rio, lattice,
         latticeExtra, gt, sparkline, jsonlite, htmlwidgets, qs,
-        getPass, keyring, safer
+        getPass, keyring, safer, htm2txt
 License: GPL (>= 2)
 Archs: x64
 
@@ -1002,10 +1003,10 @@ Suggests: testthat, XML, xml2, Hmisc, rmarkdown, chron, lubridate,
 License: GPL (>= 3)
 
 Package: htmltools
-Version: 0.5.7
+Version: 0.5.8
 Depends: R (>= 2.14.1)
-Imports: base64enc, digest, ellipsis, fastmap (>= 1.1.0), grDevices,
-        rlang (>= 1.0.0), utils
+Imports: base64enc, digest, fastmap (>= 1.1.0), grDevices, rlang (>=
+        1.0.0), utils
 Suggests: Cairo, markdown, ragg, shiny, testthat, withr
 Enhances: knitr
 License: GPL (>= 2)
@@ -1020,7 +1021,7 @@ Enhances: shiny (>= 1.1)
 License: MIT + file LICENSE
 
 Package: httpuv
-Version: 1.6.14
+Version: 1.6.15
 Depends: R (>= 2.15.1)
 Imports: later (>= 0.8.0), promises, R6, Rcpp (>= 1.0.7), utils
 LinkingTo: later, Rcpp
@@ -1043,7 +1044,7 @@ Suggests: knitr, rcorpora, rmarkdown, testthat
 License: MIT + file LICENSE
 
 Package: igraph
-Version: 2.0.2
+Version: 2.0.3
 Depends: methods, R (>= 3.5.0)
 Imports: cli, graphics, grDevices, lifecycle, magrittr, Matrix,
         pkgconfig (>= 2.0.0), rlang, stats, utils, vctrs
@@ -1214,7 +1215,7 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: lattice
-Version: 0.22-5
+Version: 0.22-6
 Priority: recommended
 Depends: R (>= 4.0.0)
 Imports: grid, grDevices, graphics, stats, utils
@@ -1224,15 +1225,15 @@ License: GPL (>= 2)
 Archs: x64
 
 Package: lava
-Version: 1.7.3
-Depends: R (>= 3.5.0)
-Imports: future.apply, grDevices, graphics, methods, numDeriv,
+Version: 1.8.0
+Depends: R (>= 3.0)
+Imports: cli, future.apply, graphics, grDevices, methods, numDeriv,
         progressr, stats, survival, SQUAREM, utils
-Suggests: KernSmooth, Matrix, Rgraphviz, data.table, ellipse, fields,
-        geepack, graph, knitr, bookdown, rmarkdown, igraph (>= 0.6),
-        lavaSearch2, lme4, mets (>= 1.1), nlme, optimx, polycor,
-        quantreg, rgl, R.rsp (>= 0.40), targeted (>= 0.2), testthat (>=
-        0.11), visNetwork, zoo
+Suggests: KernSmooth, Rgraphviz, data.table, ellipse, fields, geepack,
+        graph, knitr, rmarkdown, igraph (>= 0.6), lavaSearch2, lme4 (>=
+        1.1.35.1), MASS, Matrix (>= 1.6.3), mets (>= 1.1), nlme,
+        optimx, polycor, quantreg, rgl, targeted (>= 0.4), testthat (>=
+        0.11), visNetwork
 License: GPL-3
 
 Package: lazyeval
@@ -1543,7 +1544,7 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: parallelly
-Version: 1.37.0
+Version: 1.37.1
 Imports: parallel, tools, utils
 License: LGPL (>= 2.1)
 Archs: x64
@@ -1668,7 +1669,7 @@ License: GPL (>= 3)
 Archs: x64
 
 Package: processx
-Version: 3.8.3
+Version: 3.8.4
 Depends: R (>= 3.4.0)
 Imports: ps (>= 1.2.0), R6, utils
 Suggests: callr (>= 3.7.3), cli (>= 3.3.0), codetools, covr, curl,
@@ -1810,7 +1811,7 @@ Suggests: testthat, pryr
 License: MIT + file LICENSE
 
 Package: ragg
-Version: 1.2.7
+Version: 1.3.0
 Imports: systemfonts (>= 1.0.3), textshaping (>= 0.3.0)
 LinkingTo: systemfonts, textshaping
 Suggests: covr, graphics, grid, testthat (>= 3.0.0)
@@ -1877,7 +1878,7 @@ Suggests: xtable, RUnit, knitr, rmarkdown, devtools
 License: LGPL
 
 Package: rcdklibs
-Version: 2.8
+Version: 2.9
 Depends: R (>= 2.0.0), rJava
 License: LGPL
 
@@ -1894,7 +1895,7 @@ License: GPL (>= 2)
 Archs: x64
 
 Package: RcppArmadillo
-Version: 0.12.8.0.0
+Version: 0.12.8.1.0
 Depends: R (>= 3.3.0)
 Imports: Rcpp (>= 0.11.0), stats, utils, methods
 LinkingTo: Rcpp
@@ -2070,12 +2071,12 @@ Suggests: testthat, stringdist
 License: MIT + file LICENSE
 
 Package: rmarkdown
-Version: 2.25
+Version: 2.26
 Depends: R (>= 3.0)
 Imports: bslib (>= 0.2.5.1), evaluate (>= 0.13), fontawesome (>=
         0.5.0), htmltools (>= 0.5.1), jquerylib, jsonlite, knitr (>=
-        1.22), methods, stringr (>= 1.2.0), tinytex (>= 0.31), tools,
-        utils, xfun (>= 0.36), yaml (>= 2.1.19)
+        1.43), methods, tinytex (>= 0.31), tools, utils, xfun (>=
+        0.36), yaml (>= 2.1.19)
 Suggests: digest, dygraphs, fs, rsconnect, downlit (>= 0.4.0), katex
         (>= 1.4.0), sass (>= 0.4.0), shiny (>= 1.6.0), testthat (>=
         3.0.3), tibble, vctrs, cleanrmd, withr (>= 2.4.2)
@@ -2141,7 +2142,7 @@ License: LGPL (>= 2.1)
 Archs: x64
 
 Package: rstudioapi
-Version: 0.15.0
+Version: 0.16.0
 Suggests: testthat, knitr, rmarkdown, clipr, covr
 License: MIT + file LICENSE
 
@@ -2164,7 +2165,7 @@ License: Artistic-2.0
 Archs: x64
 
 Package: sass
-Version: 0.4.8
+Version: 0.4.9
 Imports: fs (>= 1.2.4), rlang (>= 0.4.10), htmltools (>= 0.5.1), R6,
         rappdirs
 Suggests: testthat, knitr, rmarkdown, withr, shiny, curl
@@ -2198,22 +2199,22 @@ License: GPL-3
 Archs: x64
 
 Package: shape
-Version: 1.4.6
+Version: 1.4.6.1
 Depends: R (>= 2.01)
 Imports: stats, graphics, grDevices
 License: GPL (>= 3)
 
 Package: shiny
-Version: 1.8.0
+Version: 1.8.1
 Depends: R (>= 3.0.2), methods
 Imports: utils, grDevices, httpuv (>= 1.5.2), mime (>= 0.3), jsonlite
         (>= 0.9.16), xtable, fontawesome (>= 0.4.0), htmltools (>=
         0.5.4), R6 (>= 2.0), sourcetools, later (>= 1.0.0), promises
         (>= 1.1.0), tools, crayon, rlang (>= 0.4.10), fastmap (>=
         1.1.1), withr, commonmark (>= 1.7), glue (>= 1.3.2), bslib (>=
-        0.3.0), cachem, ellipsis, lifecycle (>= 0.2.0)
-Suggests: datasets, Cairo (>= 1.5-5), testthat (>= 3.0.0), knitr (>=
-        1.6), markdown, rmarkdown, ggplot2, reactlog (>= 1.0.0),
+        0.3.0), cachem, lifecycle (>= 0.2.0)
+Suggests: datasets, DT, Cairo (>= 1.5-5), testthat (>= 3.0.0), knitr
+        (>= 1.6), markdown, rmarkdown, ggplot2, reactlog (>= 1.0.0),
         magrittr, yaml, future, dygraphs, ragg, showtext, sass
 License: GPL-3 | file LICENSE
 
@@ -2332,7 +2333,7 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: systemfonts
-Version: 1.0.5
+Version: 1.0.6
 Depends: R (>= 3.2.0)
 LinkingTo: cpp11 (>= 0.2.1)
 Suggests: covr, knitr, rmarkdown, testthat (>= 2.1.0), tools
@@ -2376,10 +2377,10 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: tidyselect
-Version: 1.2.0
+Version: 1.2.1
 Depends: R (>= 3.4)
 Imports: cli (>= 3.3.0), glue (>= 1.3.0), lifecycle (>= 1.0.3), rlang
-        (>= 1.0.4), vctrs (>= 0.4.1), withr
+        (>= 1.0.4), vctrs (>= 0.5.2), withr
 Suggests: covr, crayon, dplyr, knitr, magrittr, rmarkdown, stringr,
         testthat (>= 3.1.1), tibble (>= 2.1.3)
 License: MIT + file LICENSE
@@ -2418,7 +2419,7 @@ Suggests: RUnit
 License: GPL (>= 2)
 
 Package: tinytex
-Version: 0.49
+Version: 0.50
 Imports: xfun (>= 0.29)
 Suggests: testit, rstudioapi
 License: MIT + file LICENSE
@@ -2575,11 +2576,11 @@ License: GPL (>= 2) + file LICENSE
 Archs: x64
 
 Package: xfun
-Version: 0.42
+Version: 0.43
 Imports: grDevices, stats, tools
 Suggests: testit, parallel, codetools, rstudioapi, tinytex (>= 0.30),
         mime, markdown (>= 1.5), knitr (>= 1.42), htmltools, remotes,
-        pak, rhub, renv, curl, jsonlite, magick, yaml, rmarkdown
+        pak, rhub, renv, curl, xml2, jsonlite, magick, yaml, rmarkdown
 License: MIT + file LICENSE
 Archs: x64
 
diff --git a/bin/windows/contrib/4.2/PACKAGES.gz b/bin/windows/contrib/4.2/PACKAGES.gz
index 4019a434..b9522f7e 100644
Binary files a/bin/windows/contrib/4.2/PACKAGES.gz and b/bin/windows/contrib/4.2/PACKAGES.gz differ
diff --git a/bin/windows/contrib/4.2/PACKAGES.rds b/bin/windows/contrib/4.2/PACKAGES.rds
index 7e78fc31..e4553759 100644
Binary files a/bin/windows/contrib/4.2/PACKAGES.rds and b/bin/windows/contrib/4.2/PACKAGES.rds differ
diff --git a/bin/windows/contrib/4.2/RcppArmadillo_0.12.8.0.0.zip b/bin/windows/contrib/4.2/RcppArmadillo_0.12.8.1.0.zip
similarity index 59%
rename from bin/windows/contrib/4.2/RcppArmadillo_0.12.8.0.0.zip
rename to bin/windows/contrib/4.2/RcppArmadillo_0.12.8.1.0.zip
index 0c1e2504..fda4cd7a 100644
Binary files a/bin/windows/contrib/4.2/RcppArmadillo_0.12.8.0.0.zip and b/bin/windows/contrib/4.2/RcppArmadillo_0.12.8.1.0.zip differ
diff --git a/bin/windows/contrib/4.2/bookdown_0.37.zip b/bin/windows/contrib/4.2/bookdown_0.38.zip
similarity index 72%
rename from bin/windows/contrib/4.2/bookdown_0.37.zip
rename to bin/windows/contrib/4.2/bookdown_0.38.zip
index dc6a65b4..9b7ef91e 100644
Binary files a/bin/windows/contrib/4.2/bookdown_0.37.zip and b/bin/windows/contrib/4.2/bookdown_0.38.zip differ
diff --git a/bin/windows/contrib/4.2/bslib_0.6.1.zip b/bin/windows/contrib/4.2/bslib_0.6.1.zip
deleted file mode 100644
index c1cf1031..00000000
Binary files a/bin/windows/contrib/4.2/bslib_0.6.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/bslib_0.7.0.zip b/bin/windows/contrib/4.2/bslib_0.7.0.zip
new file mode 100644
index 00000000..1ed9601e
Binary files /dev/null and b/bin/windows/contrib/4.2/bslib_0.7.0.zip differ
diff --git a/bin/windows/contrib/4.2/callr_3.7.5.zip b/bin/windows/contrib/4.2/callr_3.7.5.zip
deleted file mode 100644
index 4d40aafe..00000000
Binary files a/bin/windows/contrib/4.2/callr_3.7.5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/callr_3.7.6.zip b/bin/windows/contrib/4.2/callr_3.7.6.zip
new file mode 100644
index 00000000..79989d40
Binary files /dev/null and b/bin/windows/contrib/4.2/callr_3.7.6.zip differ
diff --git a/bin/windows/contrib/4.2/cliqueMS_1.7.1.zip b/bin/windows/contrib/4.2/cliqueMS_1.7.1.zip
index 84833ce6..21d939ee 100644
Binary files a/bin/windows/contrib/4.2/cliqueMS_1.7.1.zip and b/bin/windows/contrib/4.2/cliqueMS_1.7.1.zip differ
diff --git a/bin/windows/contrib/4.2/curl_5.2.0.zip b/bin/windows/contrib/4.2/curl_5.2.0.zip
deleted file mode 100644
index 59f55fbb..00000000
Binary files a/bin/windows/contrib/4.2/curl_5.2.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/curl_5.2.1.zip b/bin/windows/contrib/4.2/curl_5.2.1.zip
new file mode 100644
index 00000000..f357a23e
Binary files /dev/null and b/bin/windows/contrib/4.2/curl_5.2.1.zip differ
diff --git a/bin/windows/contrib/4.2/data.table_1.15.0.zip b/bin/windows/contrib/4.2/data.table_1.15.2.zip
similarity index 51%
rename from bin/windows/contrib/4.2/data.table_1.15.0.zip
rename to bin/windows/contrib/4.2/data.table_1.15.2.zip
index b9cca2d8..aa30f2ff 100644
Binary files a/bin/windows/contrib/4.2/data.table_1.15.0.zip and b/bin/windows/contrib/4.2/data.table_1.15.2.zip differ
diff --git a/bin/windows/contrib/4.2/dbplyr_2.4.0.zip b/bin/windows/contrib/4.2/dbplyr_2.4.0.zip
deleted file mode 100644
index 5bf9a4f4..00000000
Binary files a/bin/windows/contrib/4.2/dbplyr_2.4.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/dbplyr_2.5.0.zip b/bin/windows/contrib/4.2/dbplyr_2.5.0.zip
new file mode 100644
index 00000000..d459c907
Binary files /dev/null and b/bin/windows/contrib/4.2/dbplyr_2.5.0.zip differ
diff --git a/bin/windows/contrib/4.2/digest_0.6.34.zip b/bin/windows/contrib/4.2/digest_0.6.34.zip
deleted file mode 100644
index d9675f63..00000000
Binary files a/bin/windows/contrib/4.2/digest_0.6.34.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/digest_0.6.35.zip b/bin/windows/contrib/4.2/digest_0.6.35.zip
new file mode 100644
index 00000000..c2695d8f
Binary files /dev/null and b/bin/windows/contrib/4.2/digest_0.6.35.zip differ
diff --git a/bin/windows/contrib/4.2/future.apply_1.11.1.zip b/bin/windows/contrib/4.2/future.apply_1.11.1.zip
deleted file mode 100644
index 4426535c..00000000
Binary files a/bin/windows/contrib/4.2/future.apply_1.11.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/future.apply_1.11.2.zip b/bin/windows/contrib/4.2/future.apply_1.11.2.zip
new file mode 100644
index 00000000..3c5b13af
Binary files /dev/null and b/bin/windows/contrib/4.2/future.apply_1.11.2.zip differ
diff --git a/bin/windows/contrib/4.2/future_1.33.1.zip b/bin/windows/contrib/4.2/future_1.33.1.zip
deleted file mode 100644
index 10cb1579..00000000
Binary files a/bin/windows/contrib/4.2/future_1.33.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/future_1.33.2.zip b/bin/windows/contrib/4.2/future_1.33.2.zip
new file mode 100644
index 00000000..d956c315
Binary files /dev/null and b/bin/windows/contrib/4.2/future_1.33.2.zip differ
diff --git a/bin/windows/contrib/4.2/ggplot2_3.4.4.zip b/bin/windows/contrib/4.2/ggplot2_3.4.4.zip
deleted file mode 100644
index a3686322..00000000
Binary files a/bin/windows/contrib/4.2/ggplot2_3.4.4.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/ggplot2_3.5.0.zip b/bin/windows/contrib/4.2/ggplot2_3.5.0.zip
new file mode 100644
index 00000000..03071a04
Binary files /dev/null and b/bin/windows/contrib/4.2/ggplot2_3.5.0.zip differ
diff --git a/bin/windows/contrib/4.2/globals_0.16.2.zip b/bin/windows/contrib/4.2/globals_0.16.2.zip
deleted file mode 100644
index 5a39c5ba..00000000
Binary files a/bin/windows/contrib/4.2/globals_0.16.2.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/globals_0.16.3.zip b/bin/windows/contrib/4.2/globals_0.16.3.zip
new file mode 100644
index 00000000..389e538a
Binary files /dev/null and b/bin/windows/contrib/4.2/globals_0.16.3.zip differ
diff --git a/bin/windows/contrib/4.2/htmltools_0.5.7.zip b/bin/windows/contrib/4.2/htmltools_0.5.7.zip
deleted file mode 100644
index 341e767f..00000000
Binary files a/bin/windows/contrib/4.2/htmltools_0.5.7.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/htmltools_0.5.8.zip b/bin/windows/contrib/4.2/htmltools_0.5.8.zip
new file mode 100644
index 00000000..55c6823b
Binary files /dev/null and b/bin/windows/contrib/4.2/htmltools_0.5.8.zip differ
diff --git a/bin/windows/contrib/4.2/httpuv_1.6.14.zip b/bin/windows/contrib/4.2/httpuv_1.6.14.zip
deleted file mode 100644
index 06473a37..00000000
Binary files a/bin/windows/contrib/4.2/httpuv_1.6.14.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/httpuv_1.6.15.zip b/bin/windows/contrib/4.2/httpuv_1.6.15.zip
new file mode 100644
index 00000000..0aad9ff0
Binary files /dev/null and b/bin/windows/contrib/4.2/httpuv_1.6.15.zip differ
diff --git a/bin/windows/contrib/4.2/igraph_2.0.2.zip b/bin/windows/contrib/4.2/igraph_2.0.2.zip
deleted file mode 100644
index da777a3a..00000000
Binary files a/bin/windows/contrib/4.2/igraph_2.0.2.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/igraph_2.0.3.zip b/bin/windows/contrib/4.2/igraph_2.0.3.zip
new file mode 100644
index 00000000..7ccfd596
Binary files /dev/null and b/bin/windows/contrib/4.2/igraph_2.0.3.zip differ
diff --git a/bin/windows/contrib/4.2/lattice_0.22-5.zip b/bin/windows/contrib/4.2/lattice_0.22-5.zip
deleted file mode 100644
index 5a9ee212..00000000
Binary files a/bin/windows/contrib/4.2/lattice_0.22-5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/lattice_0.22-6.zip b/bin/windows/contrib/4.2/lattice_0.22-6.zip
new file mode 100644
index 00000000..185312b5
Binary files /dev/null and b/bin/windows/contrib/4.2/lattice_0.22-6.zip differ
diff --git a/bin/windows/contrib/4.2/lava_1.7.3.zip b/bin/windows/contrib/4.2/lava_1.7.3.zip
deleted file mode 100644
index abff90bb..00000000
Binary files a/bin/windows/contrib/4.2/lava_1.7.3.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/lava_1.8.0.zip b/bin/windows/contrib/4.2/lava_1.8.0.zip
new file mode 100644
index 00000000..0d89dc5e
Binary files /dev/null and b/bin/windows/contrib/4.2/lava_1.8.0.zip differ
diff --git a/bin/windows/contrib/4.2/parallelly_1.37.0.zip b/bin/windows/contrib/4.2/parallelly_1.37.0.zip
deleted file mode 100644
index c7ca3547..00000000
Binary files a/bin/windows/contrib/4.2/parallelly_1.37.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/parallelly_1.37.1.zip b/bin/windows/contrib/4.2/parallelly_1.37.1.zip
new file mode 100644
index 00000000..65af838f
Binary files /dev/null and b/bin/windows/contrib/4.2/parallelly_1.37.1.zip differ
diff --git a/bin/windows/contrib/4.2/patRoon_2.3.1.zip b/bin/windows/contrib/4.2/patRoon_2.3.1.zip
index acdbf53d..ba1e2a18 100644
Binary files a/bin/windows/contrib/4.2/patRoon_2.3.1.zip and b/bin/windows/contrib/4.2/patRoon_2.3.1.zip differ
diff --git a/bin/windows/contrib/4.2/processx_3.8.3.zip b/bin/windows/contrib/4.2/processx_3.8.3.zip
deleted file mode 100644
index aa0284ec..00000000
Binary files a/bin/windows/contrib/4.2/processx_3.8.3.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/processx_3.8.4.zip b/bin/windows/contrib/4.2/processx_3.8.4.zip
new file mode 100644
index 00000000..b9691802
Binary files /dev/null and b/bin/windows/contrib/4.2/processx_3.8.4.zip differ
diff --git a/bin/windows/contrib/4.2/ragg_1.2.7.zip b/bin/windows/contrib/4.2/ragg_1.2.7.zip
deleted file mode 100644
index 11903b3e..00000000
Binary files a/bin/windows/contrib/4.2/ragg_1.2.7.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/ragg_1.3.0.zip b/bin/windows/contrib/4.2/ragg_1.3.0.zip
new file mode 100644
index 00000000..16df7c6c
Binary files /dev/null and b/bin/windows/contrib/4.2/ragg_1.3.0.zip differ
diff --git a/bin/windows/contrib/4.3/rcdklibs_2.8.zip b/bin/windows/contrib/4.2/rcdklibs_2.9.zip
similarity index 69%
rename from bin/windows/contrib/4.3/rcdklibs_2.8.zip
rename to bin/windows/contrib/4.2/rcdklibs_2.9.zip
index 74495318..01426ebe 100644
Binary files a/bin/windows/contrib/4.3/rcdklibs_2.8.zip and b/bin/windows/contrib/4.2/rcdklibs_2.9.zip differ
diff --git a/bin/windows/contrib/4.2/rmarkdown_2.25.zip b/bin/windows/contrib/4.2/rmarkdown_2.26.zip
similarity index 74%
rename from bin/windows/contrib/4.2/rmarkdown_2.25.zip
rename to bin/windows/contrib/4.2/rmarkdown_2.26.zip
index c3e8ab9d..c947f6bc 100644
Binary files a/bin/windows/contrib/4.2/rmarkdown_2.25.zip and b/bin/windows/contrib/4.2/rmarkdown_2.26.zip differ
diff --git a/bin/windows/contrib/4.2/rstudioapi_0.15.0.zip b/bin/windows/contrib/4.2/rstudioapi_0.15.0.zip
deleted file mode 100644
index 2b32036b..00000000
Binary files a/bin/windows/contrib/4.2/rstudioapi_0.15.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/rstudioapi_0.16.0.zip b/bin/windows/contrib/4.2/rstudioapi_0.16.0.zip
new file mode 100644
index 00000000..175bfbd2
Binary files /dev/null and b/bin/windows/contrib/4.2/rstudioapi_0.16.0.zip differ
diff --git a/bin/windows/contrib/4.2/sass_0.4.8.zip b/bin/windows/contrib/4.2/sass_0.4.8.zip
deleted file mode 100644
index 57de45e2..00000000
Binary files a/bin/windows/contrib/4.2/sass_0.4.8.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/sass_0.4.9.zip b/bin/windows/contrib/4.2/sass_0.4.9.zip
new file mode 100644
index 00000000..bcf719b2
Binary files /dev/null and b/bin/windows/contrib/4.2/sass_0.4.9.zip differ
diff --git a/bin/windows/contrib/4.2/shape_1.4.6.1.zip b/bin/windows/contrib/4.2/shape_1.4.6.1.zip
new file mode 100644
index 00000000..9c581aba
Binary files /dev/null and b/bin/windows/contrib/4.2/shape_1.4.6.1.zip differ
diff --git a/bin/windows/contrib/4.2/shape_1.4.6.zip b/bin/windows/contrib/4.2/shape_1.4.6.zip
deleted file mode 100644
index 1db07eb5..00000000
Binary files a/bin/windows/contrib/4.2/shape_1.4.6.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/shiny_1.8.0.zip b/bin/windows/contrib/4.2/shiny_1.8.1.zip
similarity index 50%
rename from bin/windows/contrib/4.2/shiny_1.8.0.zip
rename to bin/windows/contrib/4.2/shiny_1.8.1.zip
index 76cf7ad7..625acae6 100644
Binary files a/bin/windows/contrib/4.2/shiny_1.8.0.zip and b/bin/windows/contrib/4.2/shiny_1.8.1.zip differ
diff --git a/bin/windows/contrib/4.2/systemfonts_1.0.5.zip b/bin/windows/contrib/4.2/systemfonts_1.0.5.zip
deleted file mode 100644
index de8f4ffd..00000000
Binary files a/bin/windows/contrib/4.2/systemfonts_1.0.5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/systemfonts_1.0.6.zip b/bin/windows/contrib/4.2/systemfonts_1.0.6.zip
new file mode 100644
index 00000000..b013e32f
Binary files /dev/null and b/bin/windows/contrib/4.2/systemfonts_1.0.6.zip differ
diff --git a/bin/windows/contrib/4.2/tidyselect_1.2.0.zip b/bin/windows/contrib/4.2/tidyselect_1.2.0.zip
deleted file mode 100644
index 0a61a6ce..00000000
Binary files a/bin/windows/contrib/4.2/tidyselect_1.2.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/tidyselect_1.2.1.zip b/bin/windows/contrib/4.2/tidyselect_1.2.1.zip
new file mode 100644
index 00000000..9acbf57e
Binary files /dev/null and b/bin/windows/contrib/4.2/tidyselect_1.2.1.zip differ
diff --git a/bin/windows/contrib/4.2/tinytex_0.49.zip b/bin/windows/contrib/4.2/tinytex_0.49.zip
deleted file mode 100644
index 0e8f45bc..00000000
Binary files a/bin/windows/contrib/4.2/tinytex_0.49.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/tinytex_0.50.zip b/bin/windows/contrib/4.2/tinytex_0.50.zip
new file mode 100644
index 00000000..af1ee4ec
Binary files /dev/null and b/bin/windows/contrib/4.2/tinytex_0.50.zip differ
diff --git a/bin/windows/contrib/4.2/xfun_0.42.zip b/bin/windows/contrib/4.2/xfun_0.42.zip
deleted file mode 100644
index 9c70cab4..00000000
Binary files a/bin/windows/contrib/4.2/xfun_0.42.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.2/xfun_0.43.zip b/bin/windows/contrib/4.2/xfun_0.43.zip
new file mode 100644
index 00000000..34b93b18
Binary files /dev/null and b/bin/windows/contrib/4.2/xfun_0.43.zip differ
diff --git a/bin/windows/contrib/4.3/GenomeInfoDbData_1.2.11.zip b/bin/windows/contrib/4.3/GenomeInfoDbData_1.2.12.zip
similarity index 59%
rename from bin/windows/contrib/4.3/GenomeInfoDbData_1.2.11.zip
rename to bin/windows/contrib/4.3/GenomeInfoDbData_1.2.12.zip
index 3ca79973..66649bc6 100644
Binary files a/bin/windows/contrib/4.3/GenomeInfoDbData_1.2.11.zip and b/bin/windows/contrib/4.3/GenomeInfoDbData_1.2.12.zip differ
diff --git a/bin/windows/contrib/4.3/GenomeInfoDb_1.38.6.zip b/bin/windows/contrib/4.3/GenomeInfoDb_1.38.8.zip
similarity index 81%
rename from bin/windows/contrib/4.3/GenomeInfoDb_1.38.6.zip
rename to bin/windows/contrib/4.3/GenomeInfoDb_1.38.8.zip
index 37107ab8..56a39021 100644
Binary files a/bin/windows/contrib/4.3/GenomeInfoDb_1.38.6.zip and b/bin/windows/contrib/4.3/GenomeInfoDb_1.38.8.zip differ
diff --git a/bin/windows/contrib/4.3/Hmisc_5.1-1.zip b/bin/windows/contrib/4.3/Hmisc_5.1-1.zip
deleted file mode 100644
index 0220539f..00000000
Binary files a/bin/windows/contrib/4.3/Hmisc_5.1-1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/Hmisc_5.1-2.zip b/bin/windows/contrib/4.3/Hmisc_5.1-2.zip
new file mode 100644
index 00000000..1d62c167
Binary files /dev/null and b/bin/windows/contrib/4.3/Hmisc_5.1-2.zip differ
diff --git a/bin/windows/contrib/4.3/InterpretMSSpectrum_1.3.3.zip b/bin/windows/contrib/4.3/InterpretMSSpectrum_1.3.3.zip
index f6edcbf0..29ddf081 100644
Binary files a/bin/windows/contrib/4.3/InterpretMSSpectrum_1.3.3.zip and b/bin/windows/contrib/4.3/InterpretMSSpectrum_1.3.3.zip differ
diff --git a/bin/windows/contrib/4.3/MS2Tox_0.3.2.zip b/bin/windows/contrib/4.3/MS2Tox_0.3.2.zip
index 79f16e26..30487d3c 100644
Binary files a/bin/windows/contrib/4.3/MS2Tox_0.3.2.zip and b/bin/windows/contrib/4.3/MS2Tox_0.3.2.zip differ
diff --git a/bin/windows/contrib/4.3/PACKAGES b/bin/windows/contrib/4.3/PACKAGES
index 95ace2bc..1b724add 100644
--- a/bin/windows/contrib/4.3/PACKAGES
+++ b/bin/windows/contrib/4.3/PACKAGES
@@ -135,7 +135,7 @@ Suggests: covr, crayon, pillar (>= 1.2.1), testthat
 License: MIT + file LICENSE
 
 Package: bookdown
-Version: 0.37
+Version: 0.38
 Depends: R (>= 3.5.0)
 Imports: htmltools (>= 0.3.6), knitr (>= 1.38), rmarkdown (>= 2.14),
         jquerylib, xfun (>= 0.39), tinytex (>= 0.12), yaml (>= 2.1.19)
@@ -166,13 +166,13 @@ Suggests: AER, AUC, bbmle, betareg, biglm, binGroup, boot, btergm (>=
 License: MIT + file LICENSE
 
 Package: bslib
-Version: 0.6.1
+Version: 0.7.0
 Depends: R (>= 2.10)
-Imports: base64enc, cachem, grDevices, htmltools (>= 0.5.7), jquerylib
-        (>= 0.1.3), jsonlite, lifecycle, memoise (>= 2.0.1), mime,
-        rlang, sass (>= 0.4.0)
-Suggests: bsicons, curl, fontawesome, ggplot2, knitr, magrittr,
-        rappdirs, rmarkdown (>= 2.7), shiny (>= 1.8.0), testthat,
+Imports: base64enc, cachem, fastmap (>= 1.1.1), grDevices, htmltools
+        (>= 0.5.8), jquerylib (>= 0.1.3), jsonlite, lifecycle, memoise
+        (>= 2.0.1), mime, rlang, sass (>= 0.4.9)
+Suggests: bsicons, curl, fontawesome, future, ggplot2, knitr, magrittr,
+        rappdirs, rmarkdown (>= 2.7), shiny (>= 1.8.1), testthat,
         thematic, withr
 License: MIT + file LICENSE
 
@@ -195,11 +195,11 @@ Depends: R (>= 3.5.0), MASS
 License: GPL-2
 
 Package: callr
-Version: 3.7.5
+Version: 3.7.6
 Depends: R (>= 3.4)
 Imports: processx (>= 3.6.1), R6, utils
-Suggests: asciicast (>= 2.3.1), cli (>= 1.1.0), covr, mockery, ps,
-        rprojroot, spelling, testthat (>= 3.2.0), withr (>= 2.3.0)
+Suggests: asciicast (>= 2.3.1), cli (>= 1.1.0), mockery, ps, rprojroot,
+        spelling, testthat (>= 3.2.0), withr (>= 2.3.0)
 License: MIT + file LICENSE
 
 Package: CAMERA
@@ -253,8 +253,8 @@ License: BSD_3_clause + file LICENSE
 Archs: x64
 
 Package: circlize
-Version: 0.4.15
-Depends: R (>= 3.0.0), graphics
+Version: 0.4.16
+Depends: R (>= 4.0.0), graphics
 Imports: GlobalOptions (>= 0.1.2), shape, grDevices, utils, stats,
         colorspace, methods, grid
 Suggests: knitr, dendextend (>= 1.0.1), ComplexHeatmap (>= 2.0.0),
@@ -345,7 +345,7 @@ License: GPL (>= 2)
 Archs: x64
 
 Package: codetools
-Version: 0.2-19
+Version: 0.2-20
 Priority: recommended
 Depends: R (>= 2.1)
 License: GPL
@@ -400,15 +400,15 @@ Suggests: shiny, ggplot2, testthat (>= 2.1.0), sass, bslib
 License: MIT + file LICENSE
 
 Package: curl
-Version: 5.2.0
+Version: 5.2.1
 Depends: R (>= 3.0.0)
 Suggests: spelling, testthat (>= 1.0.0), knitr, jsonlite, later,
-        rmarkdown, magrittr, httpuv (>= 1.4.4), webutils
+        rmarkdown, httpuv (>= 1.4.4), webutils
 License: MIT + file LICENSE
 Archs: x64
 
 Package: data.table
-Version: 1.15.0
+Version: 1.15.4
 Depends: R (>= 3.1.0)
 Imports: methods
 Suggests: bit64 (>= 4.0.0), bit (>= 4.0.4), R.utils, xts, zoo (>=
@@ -436,17 +436,17 @@ Suggests: arrow, blob, covr, DBItest, dbplyr, downlit, dplyr, glue,
 License: LGPL (>= 2.1)
 
 Package: dbplyr
-Version: 2.4.0
+Version: 2.5.0
 Depends: R (>= 3.6)
 Imports: blob (>= 1.2.0), cli (>= 3.6.1), DBI (>= 1.1.3), dplyr (>=
         1.1.2), glue (>= 1.6.2), lifecycle (>= 1.0.3), magrittr,
         methods, pillar (>= 1.9.0), purrr (>= 1.0.1), R6 (>= 2.2.2),
         rlang (>= 1.1.1), tibble (>= 3.2.1), tidyr (>= 1.3.0),
-        tidyselect (>= 1.2.0), utils, vctrs (>= 0.6.3), withr (>=
+        tidyselect (>= 1.2.1), utils, vctrs (>= 0.6.3), withr (>=
         2.5.0)
-Suggests: bit64, covr, knitr, Lahman, nycflights13, odbc, RMariaDB (>=
-        1.2.2), rmarkdown, RPostgres (>= 1.4.5), RPostgreSQL, RSQLite
-        (>= 2.3.1), testthat (>= 3.1.10)
+Suggests: bit64, covr, knitr, Lahman, nycflights13, odbc (>= 1.4.2),
+        RMariaDB (>= 1.2.2), rmarkdown, RPostgres (>= 1.4.5),
+        RPostgreSQL, RSQLite (>= 2.3.1), testthat (>= 3.1.10)
 License: MIT + file LICENSE
 
 Package: dbscan
@@ -497,7 +497,7 @@ Imports: stats, graphics
 License: GPL (>= 2)
 
 Package: digest
-Version: 0.6.34
+Version: 0.6.35
 Depends: R (>= 3.3.0)
 Imports: utils
 Suggests: tinytest, simplermarkdown
@@ -590,8 +590,9 @@ License: GPL (>= 3)
 Archs: x64
 
 Package: estimability
-Version: 1.4.1
-Depends: stats
+Version: 1.5
+Depends: stats, R(>= 4.3.0)
+Suggests: knitr, rmarkdown
 License: GPL (>= 3)
 
 Package: evaluate
@@ -743,14 +744,14 @@ Depends: R (>= 2.8.0)
 License: LGPL-3
 
 Package: future.apply
-Version: 1.11.1
+Version: 1.11.2
 Depends: R (>= 3.2.0), future (>= 1.28.0)
 Imports: globals (>= 0.16.1), parallel, utils
 Suggests: datasets, stats, tools, listenv (>= 0.8.0), R.rsp, markdown
 License: GPL (>= 2)
 
 Package: future
-Version: 1.33.1
+Version: 1.33.2
 Imports: digest, globals (>= 0.16.1), listenv (>= 0.8.0), parallel,
         parallelly (>= 1.34.0), utils
 Suggests: methods, RhpcBLASctl, R.rsp, markdown
@@ -790,7 +791,7 @@ Suggests: covr, pkgload, testthat (>= 3.0.0), tibble, withr
 License: MIT + file LICENSE
 
 Package: GenomeInfoDb
-Version: 1.38.6
+Version: 1.38.8
 Depends: R (>= 4.0.0), methods, BiocGenerics (>= 0.37.0), S4Vectors (>=
         0.25.12), IRanges (>= 2.13.12)
 Imports: stats, stats4, utils, RCurl, GenomeInfoDbData
@@ -802,7 +803,7 @@ Suggests: R.utils, data.table, GenomicRanges, Rsamtools,
 License: Artistic-2.0
 
 Package: GenomeInfoDbData
-Version: 1.2.11
+Version: 1.2.12
 Depends: R (>= 3.3)
 License: Artistic-2.0
 
@@ -837,15 +838,15 @@ License: BSD 2-clause License + file LICENSE
 Archs: x64
 
 Package: ggplot2
-Version: 3.4.4
-Depends: R (>= 3.3)
+Version: 3.5.0
+Depends: R (>= 3.5)
 Imports: cli, glue, grDevices, grid, gtable (>= 0.1.1), isoband,
         lifecycle (> 1.0.1), MASS, mgcv, rlang (>= 1.1.0), scales (>=
-        1.2.0), stats, tibble, vctrs (>= 0.5.0), withr (>= 2.5.0)
-Suggests: covr, dplyr, ggplot2movies, hexbin, Hmisc, knitr, lattice,
-        mapproj, maps, multcomp, munsell, nlme, profvis, quantreg,
-        ragg, RColorBrewer, rmarkdown, rpart, sf (>= 0.7-3), svglite
-        (>= 1.2.0.9001), testthat (>= 3.1.2), vdiffr (>= 1.0.0), xml2
+        1.3.0), stats, tibble, vctrs (>= 0.5.0), withr (>= 2.5.0)
+Suggests: covr, dplyr, ggplot2movies, hexbin, Hmisc, knitr, mapproj,
+        maps, multcomp, munsell, nlme, profvis, quantreg, ragg (>=
+        1.2.6), RColorBrewer, rmarkdown, rpart, sf (>= 0.7-3), svglite
+        (>= 2.1.2), testthat (>= 3.1.2), vdiffr (>= 1.0.6), xml2
 Enhances: sp
 License: MIT + file LICENSE
 
@@ -869,7 +870,7 @@ Suggests: testthat (>= 1.0.0), knitr, markdown, GetoptLong
 License: MIT + file LICENSE
 
 Package: globals
-Version: 0.16.2
+Version: 0.16.3
 Depends: R (>= 3.1.2)
 Imports: codetools
 License: LGPL (>= 2.1)
@@ -988,7 +989,8 @@ Suggests: knitr, markdown, testit
 License: GPL
 
 Package: Hmisc
-Version: 5.1-1
+Version: 5.1-2
+Depends: R (>= 4.1.0)
 Imports: methods, ggplot2, cluster, rpart, nnet, foreign, gtable, grid,
         gridExtra, data.table, htmlTable (>= 1.11.0), viridis,
         htmltools, base64enc, colorspace, rmarkdown, knitr, Formula
@@ -996,7 +998,7 @@ Suggests: survival, qreport, acepack, chron, rms, mice, rstudioapi,
         tables, plotly (>= 4.5.6), rlang, plyr, VGAM, leaps, pcaPP,
         digest, parallel, polspline, abind, kableExtra, rio, lattice,
         latticeExtra, gt, sparkline, jsonlite, htmlwidgets, qs,
-        getPass, keyring, safer
+        getPass, keyring, safer, htm2txt
 License: GPL (>= 2)
 Archs: x64
 
@@ -1018,10 +1020,10 @@ Suggests: testthat, XML, xml2, Hmisc, rmarkdown, chron, lubridate,
 License: GPL (>= 3)
 
 Package: htmltools
-Version: 0.5.7
+Version: 0.5.8
 Depends: R (>= 2.14.1)
-Imports: base64enc, digest, ellipsis, fastmap (>= 1.1.0), grDevices,
-        rlang (>= 1.0.0), utils
+Imports: base64enc, digest, fastmap (>= 1.1.0), grDevices, rlang (>=
+        1.0.0), utils
 Suggests: Cairo, markdown, ragg, shiny, testthat, withr
 Enhances: knitr
 License: GPL (>= 2)
@@ -1036,7 +1038,7 @@ Enhances: shiny (>= 1.1)
 License: MIT + file LICENSE
 
 Package: httpuv
-Version: 1.6.14
+Version: 1.6.15
 Depends: R (>= 2.15.1)
 Imports: later (>= 0.8.0), promises, R6, Rcpp (>= 1.0.7), utils
 LinkingTo: later, Rcpp
@@ -1059,7 +1061,7 @@ Suggests: knitr, rcorpora, rmarkdown, testthat
 License: MIT + file LICENSE
 
 Package: igraph
-Version: 2.0.2
+Version: 2.0.3
 Depends: methods, R (>= 3.5.0)
 Imports: cli, graphics, grDevices, lifecycle, magrittr, Matrix,
         pkgconfig (>= 2.0.0), rlang, stats, utils, vctrs
@@ -1230,7 +1232,7 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: lattice
-Version: 0.22-5
+Version: 0.22-6
 Priority: recommended
 Depends: R (>= 4.0.0)
 Imports: grid, grDevices, graphics, stats, utils
@@ -1240,15 +1242,15 @@ License: GPL (>= 2)
 Archs: x64
 
 Package: lava
-Version: 1.7.3
-Depends: R (>= 3.5.0)
-Imports: future.apply, grDevices, graphics, methods, numDeriv,
+Version: 1.8.0
+Depends: R (>= 3.0)
+Imports: cli, future.apply, graphics, grDevices, methods, numDeriv,
         progressr, stats, survival, SQUAREM, utils
-Suggests: KernSmooth, Matrix, Rgraphviz, data.table, ellipse, fields,
-        geepack, graph, knitr, bookdown, rmarkdown, igraph (>= 0.6),
-        lavaSearch2, lme4, mets (>= 1.1), nlme, optimx, polycor,
-        quantreg, rgl, R.rsp (>= 0.40), targeted (>= 0.2), testthat (>=
-        0.11), visNetwork, zoo
+Suggests: KernSmooth, Rgraphviz, data.table, ellipse, fields, geepack,
+        graph, knitr, rmarkdown, igraph (>= 0.6), lavaSearch2, lme4 (>=
+        1.1.35.1), MASS, Matrix (>= 1.6.3), mets (>= 1.1), nlme,
+        optimx, polycor, quantreg, rgl, targeted (>= 0.4), testthat (>=
+        0.11), visNetwork
 License: GPL-3
 
 Package: lazyeval
@@ -1512,7 +1514,7 @@ License: LGPL
 Archs: x64
 
 Package: munsell
-Version: 0.5.0
+Version: 0.5.1
 Imports: colorspace, methods
 Suggests: ggplot2, testthat
 License: MIT + file LICENSE
@@ -1583,7 +1585,7 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: parallelly
-Version: 1.37.0
+Version: 1.37.1
 Imports: parallel, tools, utils
 License: LGPL (>= 2.1)
 Archs: x64
@@ -1708,7 +1710,7 @@ License: GPL (>= 3)
 Archs: x64
 
 Package: processx
-Version: 3.8.3
+Version: 3.8.4
 Depends: R (>= 3.4.0)
 Imports: ps (>= 1.2.0), R6, utils
 Suggests: callr (>= 3.7.3), cli (>= 3.3.0), codetools, covr, curl,
@@ -1863,7 +1865,7 @@ Suggests: testthat, pryr
 License: MIT + file LICENSE
 
 Package: ragg
-Version: 1.2.7
+Version: 1.3.0
 Imports: systemfonts (>= 1.0.3), textshaping (>= 0.3.0)
 LinkingTo: systemfonts, textshaping
 Suggests: covr, graphics, grid, testthat (>= 3.0.0)
@@ -1930,7 +1932,7 @@ Suggests: xtable, RUnit, knitr, rmarkdown, devtools
 License: LGPL
 
 Package: rcdklibs
-Version: 2.8
+Version: 2.9
 Depends: R (>= 2.0.0), rJava
 License: LGPL
 
@@ -1947,7 +1949,7 @@ License: GPL (>= 2)
 Archs: x64
 
 Package: RcppArmadillo
-Version: 0.12.8.0.0
+Version: 0.12.8.1.0
 Depends: R (>= 3.3.0)
 Imports: Rcpp (>= 0.11.0), stats, utils, methods
 LinkingTo: Rcpp
@@ -2123,12 +2125,12 @@ Suggests: testthat, stringdist
 License: MIT + file LICENSE
 
 Package: rmarkdown
-Version: 2.25
+Version: 2.26
 Depends: R (>= 3.0)
 Imports: bslib (>= 0.2.5.1), evaluate (>= 0.13), fontawesome (>=
         0.5.0), htmltools (>= 0.5.1), jquerylib, jsonlite, knitr (>=
-        1.22), methods, stringr (>= 1.2.0), tinytex (>= 0.31), tools,
-        utils, xfun (>= 0.36), yaml (>= 2.1.19)
+        1.43), methods, tinytex (>= 0.31), tools, utils, xfun (>=
+        0.36), yaml (>= 2.1.19)
 Suggests: digest, dygraphs, fs, rsconnect, downlit (>= 0.4.0), katex
         (>= 1.4.0), sass (>= 0.4.0), shiny (>= 1.6.0), testthat (>=
         3.0.3), tibble, vctrs, cleanrmd, withr (>= 2.4.2)
@@ -2183,7 +2185,7 @@ Suggests: emmeans (> 1.3.5.1), Vdgraph, conf.design, DoE.base, FrF2
 License: GPL (>= 2)
 
 Package: RSQLite
-Version: 2.3.5
+Version: 2.3.6
 Depends: R (>= 3.1.0)
 Imports: bit64, blob (>= 1.2.0), DBI (>= 1.2.0), memoise, methods,
         pkgconfig, rlang
@@ -2194,7 +2196,7 @@ License: LGPL (>= 2.1)
 Archs: x64
 
 Package: rstudioapi
-Version: 0.15.0
+Version: 0.16.0
 Suggests: testthat, knitr, rmarkdown, clipr, covr
 License: MIT + file LICENSE
 
@@ -2208,7 +2210,7 @@ Suggests: chromote, covr, knitr, R6, readr, repurrrsive, rmarkdown,
 License: MIT + file LICENSE
 
 Package: S4Arrays
-Version: 1.2.0
+Version: 1.2.1
 Depends: R (>= 4.3.0), methods, Matrix, abind, BiocGenerics (>=
         0.45.2), S4Vectors, IRanges
 Imports: stats, crayon
@@ -2229,7 +2231,7 @@ License: Artistic-2.0
 Archs: x64
 
 Package: sass
-Version: 0.4.8
+Version: 0.4.9
 Imports: fs (>= 1.2.4), rlang (>= 0.4.10), htmltools (>= 0.5.1), R6,
         rappdirs
 Suggests: testthat, knitr, rmarkdown, withr, shiny, curl
@@ -2263,22 +2265,22 @@ License: GPL-3
 Archs: x64
 
 Package: shape
-Version: 1.4.6
+Version: 1.4.6.1
 Depends: R (>= 2.01)
 Imports: stats, graphics, grDevices
 License: GPL (>= 3)
 
 Package: shiny
-Version: 1.8.0
+Version: 1.8.1
 Depends: R (>= 3.0.2), methods
 Imports: utils, grDevices, httpuv (>= 1.5.2), mime (>= 0.3), jsonlite
         (>= 0.9.16), xtable, fontawesome (>= 0.4.0), htmltools (>=
         0.5.4), R6 (>= 2.0), sourcetools, later (>= 1.0.0), promises
         (>= 1.1.0), tools, crayon, rlang (>= 0.4.10), fastmap (>=
         1.1.1), withr, commonmark (>= 1.7), glue (>= 1.3.2), bslib (>=
-        0.3.0), cachem, ellipsis, lifecycle (>= 0.2.0)
-Suggests: datasets, Cairo (>= 1.5-5), testthat (>= 3.0.0), knitr (>=
-        1.6), markdown, rmarkdown, ggplot2, reactlog (>= 1.0.0),
+        0.3.0), cachem, lifecycle (>= 0.2.0)
+Suggests: datasets, DT, Cairo (>= 1.5-5), testthat (>= 3.0.0), knitr
+        (>= 1.6), markdown, rmarkdown, ggplot2, reactlog (>= 1.0.0),
         magrittr, yaml, future, dygraphs, ragg, showtext, sass
 License: GPL-3 | file LICENSE
 
@@ -2426,7 +2428,7 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: systemfonts
-Version: 1.0.5
+Version: 1.0.6
 Depends: R (>= 3.2.0)
 LinkingTo: cpp11 (>= 0.2.1)
 Suggests: covr, knitr, rmarkdown, testthat (>= 2.1.0), tools
@@ -2470,10 +2472,10 @@ License: MIT + file LICENSE
 Archs: x64
 
 Package: tidyselect
-Version: 1.2.0
+Version: 1.2.1
 Depends: R (>= 3.4)
 Imports: cli (>= 3.3.0), glue (>= 1.3.0), lifecycle (>= 1.0.3), rlang
-        (>= 1.0.4), vctrs (>= 0.4.1), withr
+        (>= 1.0.4), vctrs (>= 0.5.2), withr
 Suggests: covr, crayon, dplyr, knitr, magrittr, rmarkdown, stringr,
         testthat (>= 3.1.1), tibble (>= 2.1.3)
 License: MIT + file LICENSE
@@ -2512,7 +2514,7 @@ Suggests: RUnit
 License: GPL (>= 2)
 
 Package: tinytex
-Version: 0.49
+Version: 0.50
 Imports: xfun (>= 0.29)
 Suggests: testit, rstudioapi
 License: MIT + file LICENSE
@@ -2670,11 +2672,11 @@ License: GPL (>= 2) + file LICENSE
 Archs: x64
 
 Package: xfun
-Version: 0.42
+Version: 0.43
 Imports: grDevices, stats, tools
 Suggests: testit, parallel, codetools, rstudioapi, tinytex (>= 0.30),
         mime, markdown (>= 1.5), knitr (>= 1.42), htmltools, remotes,
-        pak, rhub, renv, curl, jsonlite, magick, yaml, rmarkdown
+        pak, rhub, renv, curl, xml2, jsonlite, magick, yaml, rmarkdown
 License: MIT + file LICENSE
 Archs: x64
 
@@ -2730,7 +2732,7 @@ License: BSD_3_clause + file LICENSE
 Archs: x64
 
 Package: zlibbioc
-Version: 1.48.0
-Suggests: BiocStyle
+Version: 1.48.2
+Suggests: BiocStyle, knitr
 License: Artistic-2.0 + file LICENSE
 Archs: x64
diff --git a/bin/windows/contrib/4.3/PACKAGES.gz b/bin/windows/contrib/4.3/PACKAGES.gz
index 4b18e61d..3c5b9d1a 100644
Binary files a/bin/windows/contrib/4.3/PACKAGES.gz and b/bin/windows/contrib/4.3/PACKAGES.gz differ
diff --git a/bin/windows/contrib/4.3/PACKAGES.rds b/bin/windows/contrib/4.3/PACKAGES.rds
index df4a338e..f594c229 100644
Binary files a/bin/windows/contrib/4.3/PACKAGES.rds and b/bin/windows/contrib/4.3/PACKAGES.rds differ
diff --git a/bin/windows/contrib/4.3/RSQLite_2.3.5.zip b/bin/windows/contrib/4.3/RSQLite_2.3.5.zip
deleted file mode 100644
index 67d6a8e5..00000000
Binary files a/bin/windows/contrib/4.3/RSQLite_2.3.5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/RSQLite_2.3.6.zip b/bin/windows/contrib/4.3/RSQLite_2.3.6.zip
new file mode 100644
index 00000000..e67fdbf6
Binary files /dev/null and b/bin/windows/contrib/4.3/RSQLite_2.3.6.zip differ
diff --git a/bin/windows/contrib/4.3/RcppArmadillo_0.12.8.0.0.zip b/bin/windows/contrib/4.3/RcppArmadillo_0.12.8.1.0.zip
similarity index 58%
rename from bin/windows/contrib/4.3/RcppArmadillo_0.12.8.0.0.zip
rename to bin/windows/contrib/4.3/RcppArmadillo_0.12.8.1.0.zip
index 4980fc99..55f60a24 100644
Binary files a/bin/windows/contrib/4.3/RcppArmadillo_0.12.8.0.0.zip and b/bin/windows/contrib/4.3/RcppArmadillo_0.12.8.1.0.zip differ
diff --git a/bin/windows/contrib/4.3/S4Arrays_1.2.0.zip b/bin/windows/contrib/4.3/S4Arrays_1.2.0.zip
deleted file mode 100644
index 477f92d2..00000000
Binary files a/bin/windows/contrib/4.3/S4Arrays_1.2.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/S4Arrays_1.2.1.zip b/bin/windows/contrib/4.3/S4Arrays_1.2.1.zip
new file mode 100644
index 00000000..9c1b0bd6
Binary files /dev/null and b/bin/windows/contrib/4.3/S4Arrays_1.2.1.zip differ
diff --git a/bin/windows/contrib/4.3/bookdown_0.37.zip b/bin/windows/contrib/4.3/bookdown_0.38.zip
similarity index 72%
rename from bin/windows/contrib/4.3/bookdown_0.37.zip
rename to bin/windows/contrib/4.3/bookdown_0.38.zip
index f70543b1..2d56b56a 100644
Binary files a/bin/windows/contrib/4.3/bookdown_0.37.zip and b/bin/windows/contrib/4.3/bookdown_0.38.zip differ
diff --git a/bin/windows/contrib/4.3/bslib_0.6.1.zip b/bin/windows/contrib/4.3/bslib_0.6.1.zip
deleted file mode 100644
index 6bcdf82e..00000000
Binary files a/bin/windows/contrib/4.3/bslib_0.6.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/bslib_0.7.0.zip b/bin/windows/contrib/4.3/bslib_0.7.0.zip
new file mode 100644
index 00000000..4006f717
Binary files /dev/null and b/bin/windows/contrib/4.3/bslib_0.7.0.zip differ
diff --git a/bin/windows/contrib/4.3/callr_3.7.5.zip b/bin/windows/contrib/4.3/callr_3.7.5.zip
deleted file mode 100644
index d84cd411..00000000
Binary files a/bin/windows/contrib/4.3/callr_3.7.5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/callr_3.7.6.zip b/bin/windows/contrib/4.3/callr_3.7.6.zip
new file mode 100644
index 00000000..745c2fec
Binary files /dev/null and b/bin/windows/contrib/4.3/callr_3.7.6.zip differ
diff --git a/bin/windows/contrib/4.3/circlize_0.4.15.zip b/bin/windows/contrib/4.3/circlize_0.4.16.zip
similarity index 74%
rename from bin/windows/contrib/4.3/circlize_0.4.15.zip
rename to bin/windows/contrib/4.3/circlize_0.4.16.zip
index c8cbc0a4..7a956ea4 100644
Binary files a/bin/windows/contrib/4.3/circlize_0.4.15.zip and b/bin/windows/contrib/4.3/circlize_0.4.16.zip differ
diff --git a/bin/windows/contrib/4.3/cliqueMS_1.7.1.zip b/bin/windows/contrib/4.3/cliqueMS_1.7.1.zip
index fe96a275..2322086f 100644
Binary files a/bin/windows/contrib/4.3/cliqueMS_1.7.1.zip and b/bin/windows/contrib/4.3/cliqueMS_1.7.1.zip differ
diff --git a/bin/windows/contrib/4.3/codetools_0.2-19.zip b/bin/windows/contrib/4.3/codetools_0.2-19.zip
deleted file mode 100644
index 20ae2bfd..00000000
Binary files a/bin/windows/contrib/4.3/codetools_0.2-19.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/codetools_0.2-20.zip b/bin/windows/contrib/4.3/codetools_0.2-20.zip
new file mode 100644
index 00000000..20c06d36
Binary files /dev/null and b/bin/windows/contrib/4.3/codetools_0.2-20.zip differ
diff --git a/bin/windows/contrib/4.3/curl_5.2.0.zip b/bin/windows/contrib/4.3/curl_5.2.0.zip
deleted file mode 100644
index f82bb966..00000000
Binary files a/bin/windows/contrib/4.3/curl_5.2.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/curl_5.2.1.zip b/bin/windows/contrib/4.3/curl_5.2.1.zip
new file mode 100644
index 00000000..89b003b2
Binary files /dev/null and b/bin/windows/contrib/4.3/curl_5.2.1.zip differ
diff --git a/bin/windows/contrib/4.3/data.table_1.15.0.zip b/bin/windows/contrib/4.3/data.table_1.15.0.zip
deleted file mode 100644
index 83c0a8ff..00000000
Binary files a/bin/windows/contrib/4.3/data.table_1.15.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/data.table_1.15.4.zip b/bin/windows/contrib/4.3/data.table_1.15.4.zip
new file mode 100644
index 00000000..592eb617
Binary files /dev/null and b/bin/windows/contrib/4.3/data.table_1.15.4.zip differ
diff --git a/bin/windows/contrib/4.3/dbplyr_2.4.0.zip b/bin/windows/contrib/4.3/dbplyr_2.4.0.zip
deleted file mode 100644
index 36a8c1a6..00000000
Binary files a/bin/windows/contrib/4.3/dbplyr_2.4.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/dbplyr_2.5.0.zip b/bin/windows/contrib/4.3/dbplyr_2.5.0.zip
new file mode 100644
index 00000000..663fc29e
Binary files /dev/null and b/bin/windows/contrib/4.3/dbplyr_2.5.0.zip differ
diff --git a/bin/windows/contrib/4.3/digest_0.6.34.zip b/bin/windows/contrib/4.3/digest_0.6.34.zip
deleted file mode 100644
index 70ac3d0d..00000000
Binary files a/bin/windows/contrib/4.3/digest_0.6.34.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/digest_0.6.35.zip b/bin/windows/contrib/4.3/digest_0.6.35.zip
new file mode 100644
index 00000000..034aa4bf
Binary files /dev/null and b/bin/windows/contrib/4.3/digest_0.6.35.zip differ
diff --git a/bin/windows/contrib/4.3/estimability_1.4.1.zip b/bin/windows/contrib/4.3/estimability_1.4.1.zip
deleted file mode 100644
index 2528209d..00000000
Binary files a/bin/windows/contrib/4.3/estimability_1.4.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/estimability_1.5.zip b/bin/windows/contrib/4.3/estimability_1.5.zip
new file mode 100644
index 00000000..df7c4493
Binary files /dev/null and b/bin/windows/contrib/4.3/estimability_1.5.zip differ
diff --git a/bin/windows/contrib/4.3/future.apply_1.11.1.zip b/bin/windows/contrib/4.3/future.apply_1.11.1.zip
deleted file mode 100644
index 53bcce64..00000000
Binary files a/bin/windows/contrib/4.3/future.apply_1.11.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/future.apply_1.11.2.zip b/bin/windows/contrib/4.3/future.apply_1.11.2.zip
new file mode 100644
index 00000000..2590882d
Binary files /dev/null and b/bin/windows/contrib/4.3/future.apply_1.11.2.zip differ
diff --git a/bin/windows/contrib/4.3/future_1.33.1.zip b/bin/windows/contrib/4.3/future_1.33.1.zip
deleted file mode 100644
index 5b2c48a7..00000000
Binary files a/bin/windows/contrib/4.3/future_1.33.1.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/future_1.33.2.zip b/bin/windows/contrib/4.3/future_1.33.2.zip
new file mode 100644
index 00000000..4f33c721
Binary files /dev/null and b/bin/windows/contrib/4.3/future_1.33.2.zip differ
diff --git a/bin/windows/contrib/4.3/ggplot2_3.4.4.zip b/bin/windows/contrib/4.3/ggplot2_3.4.4.zip
deleted file mode 100644
index 2858fd1b..00000000
Binary files a/bin/windows/contrib/4.3/ggplot2_3.4.4.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/ggplot2_3.5.0.zip b/bin/windows/contrib/4.3/ggplot2_3.5.0.zip
new file mode 100644
index 00000000..bc3e0410
Binary files /dev/null and b/bin/windows/contrib/4.3/ggplot2_3.5.0.zip differ
diff --git a/bin/windows/contrib/4.3/globals_0.16.2.zip b/bin/windows/contrib/4.3/globals_0.16.2.zip
deleted file mode 100644
index 55e5a02e..00000000
Binary files a/bin/windows/contrib/4.3/globals_0.16.2.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/globals_0.16.3.zip b/bin/windows/contrib/4.3/globals_0.16.3.zip
new file mode 100644
index 00000000..14eedffe
Binary files /dev/null and b/bin/windows/contrib/4.3/globals_0.16.3.zip differ
diff --git a/bin/windows/contrib/4.3/htmltools_0.5.7.zip b/bin/windows/contrib/4.3/htmltools_0.5.7.zip
deleted file mode 100644
index 02752124..00000000
Binary files a/bin/windows/contrib/4.3/htmltools_0.5.7.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/htmltools_0.5.8.zip b/bin/windows/contrib/4.3/htmltools_0.5.8.zip
new file mode 100644
index 00000000..3274289b
Binary files /dev/null and b/bin/windows/contrib/4.3/htmltools_0.5.8.zip differ
diff --git a/bin/windows/contrib/4.3/httpuv_1.6.14.zip b/bin/windows/contrib/4.3/httpuv_1.6.14.zip
deleted file mode 100644
index 4a0e9684..00000000
Binary files a/bin/windows/contrib/4.3/httpuv_1.6.14.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/httpuv_1.6.15.zip b/bin/windows/contrib/4.3/httpuv_1.6.15.zip
new file mode 100644
index 00000000..6c02bbc5
Binary files /dev/null and b/bin/windows/contrib/4.3/httpuv_1.6.15.zip differ
diff --git a/bin/windows/contrib/4.3/igraph_2.0.2.zip b/bin/windows/contrib/4.3/igraph_2.0.2.zip
deleted file mode 100644
index 736a3bb9..00000000
Binary files a/bin/windows/contrib/4.3/igraph_2.0.2.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/igraph_2.0.3.zip b/bin/windows/contrib/4.3/igraph_2.0.3.zip
new file mode 100644
index 00000000..29d0b9d9
Binary files /dev/null and b/bin/windows/contrib/4.3/igraph_2.0.3.zip differ
diff --git a/bin/windows/contrib/4.3/lattice_0.22-5.zip b/bin/windows/contrib/4.3/lattice_0.22-5.zip
deleted file mode 100644
index 112cb65b..00000000
Binary files a/bin/windows/contrib/4.3/lattice_0.22-5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/lattice_0.22-6.zip b/bin/windows/contrib/4.3/lattice_0.22-6.zip
new file mode 100644
index 00000000..6f362e11
Binary files /dev/null and b/bin/windows/contrib/4.3/lattice_0.22-6.zip differ
diff --git a/bin/windows/contrib/4.3/lava_1.7.3.zip b/bin/windows/contrib/4.3/lava_1.7.3.zip
deleted file mode 100644
index 0305ae42..00000000
Binary files a/bin/windows/contrib/4.3/lava_1.7.3.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/lava_1.8.0.zip b/bin/windows/contrib/4.3/lava_1.8.0.zip
new file mode 100644
index 00000000..cf0c99fb
Binary files /dev/null and b/bin/windows/contrib/4.3/lava_1.8.0.zip differ
diff --git a/bin/windows/contrib/4.3/munsell_0.5.0.zip b/bin/windows/contrib/4.3/munsell_0.5.0.zip
deleted file mode 100644
index 481af8df..00000000
Binary files a/bin/windows/contrib/4.3/munsell_0.5.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/munsell_0.5.1.zip b/bin/windows/contrib/4.3/munsell_0.5.1.zip
new file mode 100644
index 00000000..3d7a8cf8
Binary files /dev/null and b/bin/windows/contrib/4.3/munsell_0.5.1.zip differ
diff --git a/bin/windows/contrib/4.3/parallelly_1.37.0.zip b/bin/windows/contrib/4.3/parallelly_1.37.0.zip
deleted file mode 100644
index cce883f0..00000000
Binary files a/bin/windows/contrib/4.3/parallelly_1.37.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/parallelly_1.37.1.zip b/bin/windows/contrib/4.3/parallelly_1.37.1.zip
new file mode 100644
index 00000000..84558540
Binary files /dev/null and b/bin/windows/contrib/4.3/parallelly_1.37.1.zip differ
diff --git a/bin/windows/contrib/4.3/patRoon_2.3.1.zip b/bin/windows/contrib/4.3/patRoon_2.3.1.zip
index 00dfa34f..7729f31a 100644
Binary files a/bin/windows/contrib/4.3/patRoon_2.3.1.zip and b/bin/windows/contrib/4.3/patRoon_2.3.1.zip differ
diff --git a/bin/windows/contrib/4.3/processx_3.8.3.zip b/bin/windows/contrib/4.3/processx_3.8.3.zip
deleted file mode 100644
index bf889e73..00000000
Binary files a/bin/windows/contrib/4.3/processx_3.8.3.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/processx_3.8.4.zip b/bin/windows/contrib/4.3/processx_3.8.4.zip
new file mode 100644
index 00000000..87f45e63
Binary files /dev/null and b/bin/windows/contrib/4.3/processx_3.8.4.zip differ
diff --git a/bin/windows/contrib/4.3/ragg_1.2.7.zip b/bin/windows/contrib/4.3/ragg_1.2.7.zip
deleted file mode 100644
index f1ba901d..00000000
Binary files a/bin/windows/contrib/4.3/ragg_1.2.7.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/ragg_1.3.0.zip b/bin/windows/contrib/4.3/ragg_1.3.0.zip
new file mode 100644
index 00000000..e2e1af9c
Binary files /dev/null and b/bin/windows/contrib/4.3/ragg_1.3.0.zip differ
diff --git a/bin/windows/contrib/4.2/rcdklibs_2.8.zip b/bin/windows/contrib/4.3/rcdklibs_2.9.zip
similarity index 69%
rename from bin/windows/contrib/4.2/rcdklibs_2.8.zip
rename to bin/windows/contrib/4.3/rcdklibs_2.9.zip
index bad13049..8bd76818 100644
Binary files a/bin/windows/contrib/4.2/rcdklibs_2.8.zip and b/bin/windows/contrib/4.3/rcdklibs_2.9.zip differ
diff --git a/bin/windows/contrib/4.3/rmarkdown_2.25.zip b/bin/windows/contrib/4.3/rmarkdown_2.26.zip
similarity index 74%
rename from bin/windows/contrib/4.3/rmarkdown_2.25.zip
rename to bin/windows/contrib/4.3/rmarkdown_2.26.zip
index 25f0004e..3fe71486 100644
Binary files a/bin/windows/contrib/4.3/rmarkdown_2.25.zip and b/bin/windows/contrib/4.3/rmarkdown_2.26.zip differ
diff --git a/bin/windows/contrib/4.3/rstudioapi_0.15.0.zip b/bin/windows/contrib/4.3/rstudioapi_0.15.0.zip
deleted file mode 100644
index c2ea3b0b..00000000
Binary files a/bin/windows/contrib/4.3/rstudioapi_0.15.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/rstudioapi_0.16.0.zip b/bin/windows/contrib/4.3/rstudioapi_0.16.0.zip
new file mode 100644
index 00000000..dec0cefc
Binary files /dev/null and b/bin/windows/contrib/4.3/rstudioapi_0.16.0.zip differ
diff --git a/bin/windows/contrib/4.3/sass_0.4.8.zip b/bin/windows/contrib/4.3/sass_0.4.9.zip
similarity index 54%
rename from bin/windows/contrib/4.3/sass_0.4.8.zip
rename to bin/windows/contrib/4.3/sass_0.4.9.zip
index 881f3095..bfed8aa3 100644
Binary files a/bin/windows/contrib/4.3/sass_0.4.8.zip and b/bin/windows/contrib/4.3/sass_0.4.9.zip differ
diff --git a/bin/windows/contrib/4.3/shape_1.4.6.1.zip b/bin/windows/contrib/4.3/shape_1.4.6.1.zip
new file mode 100644
index 00000000..e8fe65f6
Binary files /dev/null and b/bin/windows/contrib/4.3/shape_1.4.6.1.zip differ
diff --git a/bin/windows/contrib/4.3/shape_1.4.6.zip b/bin/windows/contrib/4.3/shape_1.4.6.zip
deleted file mode 100644
index 088adde8..00000000
Binary files a/bin/windows/contrib/4.3/shape_1.4.6.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/shiny_1.8.0.zip b/bin/windows/contrib/4.3/shiny_1.8.1.zip
similarity index 50%
rename from bin/windows/contrib/4.3/shiny_1.8.0.zip
rename to bin/windows/contrib/4.3/shiny_1.8.1.zip
index 790544c2..d18b129a 100644
Binary files a/bin/windows/contrib/4.3/shiny_1.8.0.zip and b/bin/windows/contrib/4.3/shiny_1.8.1.zip differ
diff --git a/bin/windows/contrib/4.3/systemfonts_1.0.5.zip b/bin/windows/contrib/4.3/systemfonts_1.0.5.zip
deleted file mode 100644
index 98563fa1..00000000
Binary files a/bin/windows/contrib/4.3/systemfonts_1.0.5.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/systemfonts_1.0.6.zip b/bin/windows/contrib/4.3/systemfonts_1.0.6.zip
new file mode 100644
index 00000000..94af8425
Binary files /dev/null and b/bin/windows/contrib/4.3/systemfonts_1.0.6.zip differ
diff --git a/bin/windows/contrib/4.3/tidyselect_1.2.0.zip b/bin/windows/contrib/4.3/tidyselect_1.2.0.zip
deleted file mode 100644
index acd2f84d..00000000
Binary files a/bin/windows/contrib/4.3/tidyselect_1.2.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/tidyselect_1.2.1.zip b/bin/windows/contrib/4.3/tidyselect_1.2.1.zip
new file mode 100644
index 00000000..17e7d16a
Binary files /dev/null and b/bin/windows/contrib/4.3/tidyselect_1.2.1.zip differ
diff --git a/bin/windows/contrib/4.3/tinytex_0.49.zip b/bin/windows/contrib/4.3/tinytex_0.49.zip
deleted file mode 100644
index 15170d68..00000000
Binary files a/bin/windows/contrib/4.3/tinytex_0.49.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/tinytex_0.50.zip b/bin/windows/contrib/4.3/tinytex_0.50.zip
new file mode 100644
index 00000000..9a0e2c13
Binary files /dev/null and b/bin/windows/contrib/4.3/tinytex_0.50.zip differ
diff --git a/bin/windows/contrib/4.3/xfun_0.42.zip b/bin/windows/contrib/4.3/xfun_0.42.zip
deleted file mode 100644
index a9b34495..00000000
Binary files a/bin/windows/contrib/4.3/xfun_0.42.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/xfun_0.43.zip b/bin/windows/contrib/4.3/xfun_0.43.zip
new file mode 100644
index 00000000..b44ae4d2
Binary files /dev/null and b/bin/windows/contrib/4.3/xfun_0.43.zip differ
diff --git a/bin/windows/contrib/4.3/zlibbioc_1.48.0.zip b/bin/windows/contrib/4.3/zlibbioc_1.48.0.zip
deleted file mode 100644
index c2d704c5..00000000
Binary files a/bin/windows/contrib/4.3/zlibbioc_1.48.0.zip and /dev/null differ
diff --git a/bin/windows/contrib/4.3/zlibbioc_1.48.2.zip b/bin/windows/contrib/4.3/zlibbioc_1.48.2.zip
new file mode 100644
index 00000000..1eb2af34
Binary files /dev/null and b/bin/windows/contrib/4.3/zlibbioc_1.48.2.zip differ
diff --git a/patRoonDeps-4.2.tsv b/patRoonDeps-4.2.tsv
index 466bfc85..b82eed8c 100644
--- a/patRoonDeps-4.2.tsv
+++ b/patRoonDeps-4.2.tsv
@@ -16,13 +16,13 @@ bit	4.0.5
 bit64	4.0.5	
 bitops	1.0-7	
 blob	1.2.4	
-bookdown	0.37	
+bookdown	0.38	
 broom	1.0.5	
-bslib	0.6.1	
+bslib	0.7.0	
 ca	0.71.1	
 cachem	1.0.8	
 calibrate	1.7.7	
-callr	3.7.5	
+callr	3.7.6	
 CAMERA	1.54.0	
 caret	6.0-94	
 caTools	1.18.2	
@@ -46,17 +46,17 @@ conflicted	1.2.0
 cpp11	0.4.7	
 crayon	1.5.2	
 crosstalk	1.2.1	
-curl	5.2.0	
-data.table	1.15.0	
+curl	5.2.1	
+data.table	1.15.2	
 data.tree	1.1.0	
 DBI	1.2.2	
-dbplyr	2.4.0	
+dbplyr	2.5.0	
 dbscan	1.1-12	
 DelayedArray	0.23.2	
 dendextend	1.17.1	
 DEoptimR	1.1-3	
 diagram	1.6.5	
-digest	0.6.34	
+digest	0.6.35	
 docopt	0.7.1	
 doParallel	1.0.17	
 dplyr	1.1.4	
@@ -89,20 +89,20 @@ fst	0.9.8
 fstcore	0.9.18	
 futile.logger	1.4.3	
 futile.options	1.0.1	
-future	1.33.1	
-future.apply	1.11.1	
+future	1.33.2	
+future.apply	1.11.2	
 GA	3.2.4	
 gargle	1.5.2	
 gclus	1.3.2	
 generics	0.1.3	
 GenomeInfoDb	1.34.9	
-GenomeInfoDbData	1.2.11	f3111730888a3d83e9465ffa2552003de153bbf2
+GenomeInfoDbData	1.2.12	19f191e01a4ca92f1b8ca4307788b08f34287b7a
 GenomicRanges	1.50.2	
 getPass	0.2-4	
-ggplot2	3.4.4	
+ggplot2	3.5.0	
 ggrepel	0.9.5	
 GlobalOptions	0.1.2	
-globals	0.16.2	
+globals	0.16.3	
 glue	1.7.0	
 googledrive	2.1.1	
 googlesheets4	1.1.1	
@@ -116,15 +116,15 @@ hardhat	1.3.1
 haven	2.5.4	
 heatmaply	1.5.0	
 highr	0.10	
-Hmisc	5.1-1	
+Hmisc	5.1-2	
 hms	1.1.3	
 htmlTable	2.4.2	
-htmltools	0.5.7	
+htmltools	0.5.8	
 htmlwidgets	1.6.4	
-httpuv	1.6.14	
+httpuv	1.6.15	
 httr	1.4.7	
 ids	1.0.1	
-igraph	2.0.2	
+igraph	2.0.3	
 impute	1.72.3	
 InterpretMSSpectrum	1.3.3	0731d92accdf5db2a6d7b03c24b2d324b67b1c72
 ipred	0.9-14	
@@ -145,8 +145,8 @@ labeling	0.4.3
 labelled	2.12.0	
 lambda.r	1.2.4	
 later	1.3.2	
-lattice	0.22-5	
-lava	1.7.3	
+lattice	0.22-6	
+lava	1.8.0	
 lazyeval	0.2.2	
 lifecycle	1.0.4	
 limma	3.54.2	
@@ -169,7 +169,7 @@ MLmetrics	1.1.1
 ModelMetrics	1.2.2.2	
 modelr	0.1.11	
 MS2Quant	1.1.0	46e0c77ef4961a29a73a388105eeb28e33839630
-MS2Tox	0.3.2	9895f745536bf7d244f2f05cef186f9fc91be602
+MS2Tox	0.3.2	259b4f70ea6ee2fbd4ff68b43eaa3633b0a0e891
 MsCoreUtils	1.10.0	
 MsFeatures	1.6.0	
 MSnbase	2.24.2	
@@ -185,8 +185,8 @@ nontarget	2.2	e30221585182bc66e1f8e1113b2c1103a0f2cb56
 nontargetData	1.1	75b2a92cd549f72cc71dfe7b86bd42947d62f2c4
 numDeriv	2016.8-1.1	
 openssl	2.1.1	
-parallelly	1.37.0	
-patRoon	2.3.1	32746bbfaa262d367ff0162c349c567c4bedd6c4
+parallelly	1.37.1	
+patRoon	2.3.1	48004a15afe9a7a220d7d36e7ad287aa6fc9a50e
 pcaMethods	1.90.0	
 permute	0.9-7	
 pillar	1.9.0	
@@ -199,7 +199,7 @@ png	0.1-8
 preprocessCore	1.60.2	
 prettyunits	1.2.0	
 pROC	1.18.5	
-processx	3.8.3	
+processx	3.8.4	
 prodlim	2023.08.28	
 progress	1.2.3	
 progressr	0.14.0	
@@ -217,7 +217,7 @@ R.methodsS3	1.8.2
 R.oo	1.26.0	
 R.utils	2.12.3	
 R6	2.5.1	
-ragg	1.2.7	
+ragg	1.3.0	
 RAMClustR	1.3.1	e005614d808e0ca93c459ec8cc103b87cd5d11fd
 randomForest	4.7-1.1	
 RANN	2.6.1	
@@ -226,10 +226,10 @@ rappdirs	0.3.3
 RBGL	1.74.0	
 rbibutils	2.2.16	
 rcdk	3.8.1	
-rcdklibs	2.8	
+rcdklibs	2.9	
 RColorBrewer	1.1-3	
 Rcpp	1.0.12	
-RcppArmadillo	0.12.8.0.0	
+RcppArmadillo	0.12.8.1.0	
 RCurl	1.98-1.14	
 RDCOMClient	0.95-1	1554833f8659461427a93732119756ae1c25bc32
 Rdisop	1.58.0	
@@ -251,7 +251,7 @@ Rhdf5lib	1.20.0
 rJava	1.0-11	
 rlang	1.1.3	
 rlist	0.4.6.2	
-rmarkdown	2.25	
+rmarkdown	2.26	
 robustbase	0.99-2	
 ROCR	1.0-11	
 ropls	1.30.0	
@@ -259,15 +259,15 @@ rpart	4.1.23
 rprojroot	2.0.4	
 rsm	2.10.4	
 RSQLite	2.3.5	
-rstudioapi	0.15.0	
+rstudioapi	0.16.0	
 rvest	1.0.4	
 S4Vectors	0.36.2	
-sass	0.4.8	
+sass	0.4.9	
 scales	1.3.0	
 selectr	0.4-2	
 seriation	1.5.4	
-shape	1.4.6	
-shiny	1.8.0	
+shape	1.4.6.1	
+shiny	1.8.1	
 shinyjs	2.1.0	
 slam	0.1-50	
 snow	0.4-4	
@@ -282,15 +282,15 @@ SummarizedExperiment	1.28.0
 survival	3.5-8	
 svglite	2.1.3	
 sys	3.4.2	
-systemfonts	1.0.5	
+systemfonts	1.0.6	
 textshaping	0.3.7	
 tibble	3.2.1	
 tidyr	1.3.1	
-tidyselect	1.2.0	
+tidyselect	1.2.1	
 tidyverse	2.0.0	
 timechange	0.3.0	
 timeDate	4032.109	
-tinytex	0.49	
+tinytex	0.50	
 TSP	1.2-4	
 tzdb	0.4.0	
 UpSetR	1.4.0	
@@ -308,7 +308,7 @@ webchem	1.3.0
 webshot	0.5.5	
 withr	3.0.0	
 xcms	3.20.0	
-xfun	0.42	
+xfun	0.43	
 xgboost	1.7.7.1	
 XML	3.99-0.16.1	
 xml2	1.3.6	
diff --git a/patRoonDeps-4.3.tsv b/patRoonDeps-4.3.tsv
index 3a065d4d..ae788989 100644
--- a/patRoonDeps-4.3.tsv
+++ b/patRoonDeps-4.3.tsv
@@ -18,19 +18,19 @@ bit	4.0.5
 bit64	4.0.5	
 bitops	1.0-7	
 blob	1.2.4	
-bookdown	0.37	
+bookdown	0.38	
 broom	1.0.5	
-bslib	0.6.1	
+bslib	0.7.0	
 ca	0.71.1	
 cachem	1.0.8	
 calibrate	1.7.7	
-callr	3.7.5	
+callr	3.7.6	
 CAMERA	1.58.0	
 caret	6.0-94	
 caTools	1.18.2	
 cellranger	1.1.0	
 checkmate	2.3.1	
-circlize	0.4.15	
+circlize	0.4.16	
 Ckmeans.1d.dp	4.3.5	
 class	7.3-22	
 classInt	0.4-10	
@@ -40,7 +40,7 @@ cliqueMS	1.7.1	cb569e0b78ce0fa4254f1393874762bed08fa855
 clock	0.7.0	
 clue	0.3-65	
 cluster	2.1.6	
-codetools	0.2-19	
+codetools	0.2-20	
 colorspace	2.1-0	
 combinat	0.0-8	
 commonmark	1.9.1	
@@ -48,17 +48,17 @@ conflicted	1.2.0
 cpp11	0.4.7	
 crayon	1.5.2	
 crosstalk	1.2.1	
-curl	5.2.0	
-data.table	1.15.0	
+curl	5.2.1	
+data.table	1.15.4	
 data.tree	1.1.0	
 DBI	1.2.2	
-dbplyr	2.4.0	
+dbplyr	2.5.0	
 dbscan	1.1-12	
 DelayedArray	0.28.0	
 dendextend	1.17.1	
 DEoptimR	1.1-3	
 diagram	1.6.5	
-digest	0.6.34	
+digest	0.6.35	
 docopt	0.7.1	
 doParallel	1.0.17	
 dplyr	1.1.4	
@@ -70,7 +70,7 @@ egg	0.4.5
 ellipsis	0.3.2	
 enviPat	2.6	
 enviPick	1.7	d346b23b1f7dc7a226c4e3a45b74fcc617e19c1b
-estimability	1.4.1	
+estimability	1.5	
 evaluate	0.23	
 fansi	1.0.6	
 farver	2.1.1	
@@ -91,20 +91,20 @@ fst	0.9.8
 fstcore	0.9.18	
 futile.logger	1.4.3	
 futile.options	1.0.1	
-future	1.33.1	
-future.apply	1.11.1	
+future	1.33.2	
+future.apply	1.11.2	
 GA	3.2.4	
 gargle	1.5.2	
 gclus	1.3.2	
 generics	0.1.3	
-GenomeInfoDb	1.38.6	
-GenomeInfoDbData	1.2.11	f3111730888a3d83e9465ffa2552003de153bbf2
+GenomeInfoDb	1.38.8	
+GenomeInfoDbData	1.2.12	19f191e01a4ca92f1b8ca4307788b08f34287b7a
 GenomicRanges	1.54.1	
 getPass	0.2-4	
-ggplot2	3.4.4	
+ggplot2	3.5.0	
 ggrepel	0.9.5	
 GlobalOptions	0.1.2	
-globals	0.16.2	
+globals	0.16.3	
 glue	1.7.0	
 googledrive	2.1.1	
 googlesheets4	1.1.1	
@@ -118,15 +118,15 @@ hardhat	1.3.1
 haven	2.5.4	
 heatmaply	1.5.0	
 highr	0.10	
-Hmisc	5.1-1	
+Hmisc	5.1-2	
 hms	1.1.3	
 htmlTable	2.4.2	
-htmltools	0.5.7	
+htmltools	0.5.8	
 htmlwidgets	1.6.4	
-httpuv	1.6.14	
+httpuv	1.6.15	
 httr	1.4.7	
 ids	1.0.1	
-igraph	2.0.2	
+igraph	2.0.3	
 impute	1.76.0	
 InterpretMSSpectrum	1.3.3	0731d92accdf5db2a6d7b03c24b2d324b67b1c72
 ipred	0.9-14	
@@ -147,8 +147,8 @@ labeling	0.4.3
 labelled	2.12.0	
 lambda.r	1.2.4	
 later	1.3.2	
-lattice	0.22-5	
-lava	1.7.3	
+lattice	0.22-6	
+lava	1.8.0	
 lazyeval	0.2.2	
 lifecycle	1.0.4	
 limma	3.58.1	
@@ -172,7 +172,7 @@ MLmetrics	1.1.1
 ModelMetrics	1.2.2.2	
 modelr	0.1.11	
 MS2Quant	1.1.0	46e0c77ef4961a29a73a388105eeb28e33839630
-MS2Tox	0.3.2	9895f745536bf7d244f2f05cef186f9fc91be602
+MS2Tox	0.3.2	259b4f70ea6ee2fbd4ff68b43eaa3633b0a0e891
 MsCoreUtils	1.14.1	
 MsExperiment	1.4.0	
 MsFeatures	1.10.0	
@@ -180,7 +180,7 @@ MSnbase	2.28.1
 MultiAssayExperiment	1.28.0	
 MultiDataSet	1.30.0	
 multtest	2.58.0	
-munsell	0.5.0	
+munsell	0.5.1	
 mzID	1.40.0	
 mzR	2.36.0	
 ncdf4	1.22	
@@ -190,8 +190,8 @@ nontarget	2.2	e30221585182bc66e1f8e1113b2c1103a0f2cb56
 nontargetData	1.1	75b2a92cd549f72cc71dfe7b86bd42947d62f2c4
 numDeriv	2016.8-1.1	
 openssl	2.1.1	
-parallelly	1.37.0	
-patRoon	2.3.1	32746bbfaa262d367ff0162c349c567c4bedd6c4
+parallelly	1.37.1	
+patRoon	2.3.1	48004a15afe9a7a220d7d36e7ad287aa6fc9a50e
 pcaMethods	1.94.0	
 permute	0.9-7	
 pillar	1.9.0	
@@ -204,7 +204,7 @@ png	0.1-8
 preprocessCore	1.64.0	
 prettyunits	1.2.0	
 pROC	1.18.5	
-processx	3.8.3	
+processx	3.8.4	
 prodlim	2023.08.28	
 progress	1.2.3	
 progressr	0.14.0	
@@ -223,7 +223,7 @@ R.methodsS3	1.8.2
 R.oo	1.26.0	
 R.utils	2.12.3	
 R6	2.5.1	
-ragg	1.2.7	
+ragg	1.3.0	
 RAMClustR	1.3.1	e005614d808e0ca93c459ec8cc103b87cd5d11fd
 randomForest	4.7-1.1	
 RANN	2.6.1	
@@ -232,10 +232,10 @@ rappdirs	0.3.3
 RBGL	1.78.0	
 rbibutils	2.2.16	
 rcdk	3.8.1	
-rcdklibs	2.8	
+rcdklibs	2.9	
 RColorBrewer	1.1-3	
 Rcpp	1.0.12	
-RcppArmadillo	0.12.8.0.0	
+RcppArmadillo	0.12.8.1.0	
 RCurl	1.98-1.14	
 RDCOMClient	0.95-1	1554833f8659461427a93732119756ae1c25bc32
 Rdisop	1.62.0	
@@ -257,24 +257,24 @@ Rhdf5lib	1.24.2
 rJava	1.0-11	
 rlang	1.1.3	
 rlist	0.4.6.2	
-rmarkdown	2.25	
+rmarkdown	2.26	
 robustbase	0.99-2	
 ROCR	1.0-11	
 ropls	1.34.0	
 rpart	4.1.23	
 rprojroot	2.0.4	
 rsm	2.10.4	
-RSQLite	2.3.5	
-rstudioapi	0.15.0	
+RSQLite	2.3.6	
+rstudioapi	0.16.0	
 rvest	1.0.4	
-S4Arrays	1.2.0	
+S4Arrays	1.2.1	
 S4Vectors	0.40.2	
-sass	0.4.8	
+sass	0.4.9	
 scales	1.3.0	
 selectr	0.4-2	
 seriation	1.5.4	
-shape	1.4.6	
-shiny	1.8.0	
+shape	1.4.6.1	
+shiny	1.8.1	
 shinyjs	2.1.0	
 slam	0.1-50	
 snow	0.4-4	
@@ -292,15 +292,15 @@ SummarizedExperiment	1.32.0
 survival	3.5-8	
 svglite	2.1.3	
 sys	3.4.2	
-systemfonts	1.0.5	
+systemfonts	1.0.6	
 textshaping	0.3.7	
 tibble	3.2.1	
 tidyr	1.3.1	
-tidyselect	1.2.0	
+tidyselect	1.2.1	
 tidyverse	2.0.0	
 timechange	0.3.0	
 timeDate	4032.109	
-tinytex	0.49	
+tinytex	0.50	
 TSP	1.2-4	
 tzdb	0.4.0	
 UpSetR	1.4.0	
@@ -318,11 +318,11 @@ webchem	1.3.0
 webshot	0.5.5	
 withr	3.0.0	
 xcms	4.0.2	
-xfun	0.42	
+xfun	0.43	
 xgboost	1.7.7.1	
 XML	3.99-0.16.1	
 xml2	1.3.6	
 xtable	1.8-4	
 XVector	0.42.0	
 yaml	2.3.8	
-zlibbioc	1.48.0	
+zlibbioc	1.48.2