diff --git a/ci/build_wheel_cuproj.sh b/ci/build_wheel_cuproj.sh
index 6001e44e9..4b29fbb46 100755
--- a/ci/build_wheel_cuproj.sh
+++ b/ci/build_wheel_cuproj.sh
@@ -3,4 +3,7 @@
 
 set -euo pipefail
 
-ci/build_wheel.sh cuproj python/cuproj python
+package_dir="python/cuproj"
+
+ci/build_wheel.sh cuproj ${package_dir} python
+ci/validate_wheel.sh ${package_dir} final_dist
diff --git a/ci/build_wheel_cuspatial.sh b/ci/build_wheel_cuspatial.sh
index e581a3e76..780ac0710 100755
--- a/ci/build_wheel_cuspatial.sh
+++ b/ci/build_wheel_cuspatial.sh
@@ -3,6 +3,8 @@
 
 set -euo pipefail
 
+package_dir="python/cuspatial"
+
 RAPIDS_PY_CUDA_SUFFIX="$(rapids-wheel-ctk-name-gen ${RAPIDS_CUDA_VERSION})"
 
 # Downloads libcuspatial wheel from this current build,
@@ -14,4 +16,5 @@ RAPIDS_PY_WHEEL_NAME="libcuspatial_${RAPIDS_PY_CUDA_SUFFIX}" rapids-download-whe
 echo "libcuspatial-${RAPIDS_PY_CUDA_SUFFIX} @ file://$(echo /tmp/libcuspatial_dist/libcuspatial_*.whl)" > /tmp/constraints.txt
 export PIP_CONSTRAINT="/tmp/constraints.txt"
 
-ci/build_wheel.sh cuspatial python/cuspatial python
+ci/build_wheel.sh cuspatial ${package_dir} python
+ci/validate_wheel.sh ${package_dir} final_dist
diff --git a/ci/build_wheel_libcuspatial.sh b/ci/build_wheel_libcuspatial.sh
index ed3822207..b6582d87f 100755
--- a/ci/build_wheel_libcuspatial.sh
+++ b/ci/build_wheel_libcuspatial.sh
@@ -3,6 +3,7 @@
 
 set -euo pipefail
 
+package_dir="python/libcuspatial"
 package_name="libcuspatial"
 
 rapids-logger "Generating build requirements"
@@ -25,4 +26,5 @@ python -m pip install \
 # 0 really means "add --no-build-isolation" (ref: https://github.com/pypa/pip/issues/5735)
 export PIP_NO_BUILD_ISOLATION=0
 
-ci/build_wheel.sh "${package_name}" python/libcuspatial cpp
+ci/build_wheel.sh "${package_name}" ${package_dir} cpp
+ci/validate_wheel.sh ${package_dir} final_dist
diff --git a/ci/validate_wheel.sh b/ci/validate_wheel.sh
new file mode 100755
index 000000000..5910a5c59
--- /dev/null
+++ b/ci/validate_wheel.sh
@@ -0,0 +1,21 @@
+#!/bin/bash
+# Copyright (c) 2024, NVIDIA CORPORATION.
+
+set -euo pipefail
+
+package_dir=$1
+wheel_dir_relative_path=$2
+
+cd "${package_dir}"
+
+rapids-logger "validate packages with 'pydistcheck'"
+
+pydistcheck \
+    --inspect \
+    "$(echo ${wheel_dir_relative_path}/*.whl)"
+
+rapids-logger "validate packages with 'twine'"
+
+twine check \
+    --strict \
+    "$(echo ${wheel_dir_relative_path}/*.whl)"
diff --git a/python/cuproj/pyproject.toml b/python/cuproj/pyproject.toml
index 35a95c728..c8049eadb 100644
--- a/python/cuproj/pyproject.toml
+++ b/python/cuproj/pyproject.toml
@@ -126,3 +126,11 @@ requires = [
     "ninja",
     "wheel",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../../dependencies.yaml and run `rapids-dependency-file-generator`.
+
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
diff --git a/python/cuspatial/pyproject.toml b/python/cuspatial/pyproject.toml
index c497434c4..662648337 100644
--- a/python/cuspatial/pyproject.toml
+++ b/python/cuspatial/pyproject.toml
@@ -145,3 +145,11 @@ requires = [
     "rmm==24.12.*,>=0.0.0a0",
     "wheel",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../../dependencies.yaml and run `rapids-dependency-file-generator`.
+
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'
diff --git a/python/libcuspatial/pyproject.toml b/python/libcuspatial/pyproject.toml
index 1de8df8c1..725d2d882 100644
--- a/python/libcuspatial/pyproject.toml
+++ b/python/libcuspatial/pyproject.toml
@@ -75,3 +75,11 @@ requires = [
     "ninja",
     "wheel",
 ] # This list was generated by `rapids-dependency-file-generator`. To make changes, edit ../../dependencies.yaml and run `rapids-dependency-file-generator`.
+
+[tool.pydistcheck]
+select = [
+    "distro-too-large-compressed",
+]
+
+# PyPI limit is 100 MiB, fail CI before we get too close to that
+max_allowed_size_compressed = '75M'