diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot-1.png b/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot-1.png index 6e50866..94cb7a0 100644 Binary files a/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot-1.png and b/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot-1.png differ diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot_5y-1.png b/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot_5y-1.png index ddddb5c..f4a8061 100644 Binary files a/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot_5y-1.png and b/reproduction/outputs/Sen1_No_Smoking_Cessation_CEplot_5y-1.png differ diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessationceplane.csv b/reproduction/outputs/Sen1_No_Smoking_Cessationceplane.csv index 83f37ab..7fd0674 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessationceplane.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessationceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37198402,1,79611221702.1073,2140.17854052191,0,2140.17854052191,466612084.315661,12.5438744469631,0,12.5438744469631,0,0,NA,NA,0 -"S1a",37192142,1,90029166180.6185,2420.6502056434,0,2420.6502056434,467067251.851173,12.5582240423575,0,12.5582240423575,280.471665121491,0.0143495953943766,19545.6148701867,18424.9596168519,437.008104597335 -"S1b",37187925,1,87358830750.2865,2349.1181815142,0,2349.1181815142,466782406.198794,12.5519884800992,0,12.5519884800992,208.939640992292,0.00811403313612935,25750.4051914635,23225.5913763347,196.762015814078 -"S1c",37195823,1,88369606438.0401,2375.79382066745,0,2375.79382066745,466792527.490138,12.5495953534927,0,12.5495953534927,235.615280145537,0.00572090652963908,41184.9553781123,35616.3831043441,50.4300463363761 -"S2NoCD",22078475,0.593532888859043,58623262797.6865,2655.22246430908,1388.09922193545,2140.17854052191,270860548.807215,12.268082320324,12.9465926329172,12.5438744469631,0,0,NA,NA,0 -"S2a",22076350,0.593475762749163,63456641764.5573,2874.4172729893,1388.09922193545,2270.19296097248,271102266.321126,12.2802123684905,12.9465926329172,12.5511120972056,130.014420450572,0.00723765024251577,17963.6230121808,18070.39886982,231.86809167522 -"S3NoCD",17251004,0.463756588253442,49706422473.1814,2881.36403383718,1499.18296255611,2140.17854052191,193732612.293423,11.2302224434834,13.6799532461446,12.5438744469631,0,0,NA,NA,1.16415321826935e-10 -"S3a",17249134,0.463706317276748,52783263534.7295,3060.05295887489,1499.18296255611,2222.96824029686,193741259.214591,11.2319412217791,13.6799532461446,12.5447946056769,82.7896997749544,0.000920158713757502,89973.2823665601,103962.753948155,-36.781764086918 -"S3b",17250219,0.46373548519638,54744732216.0787,3173.56737419268,1499.18296255611,2275.65443009165,193956703.474523,11.2437241216777,13.6799532461446,12.5501873510604,135.475889569744,0.00631290409728891,21460.1532799974,21642.0015461401,180.169315294828 -"S3c",17252836,0.463805837680877,53445425795.8674,3097.77626100818,1499.18296255611,2240.61986645571,193919004.9689,11.2398335536778,13.6799532461446,12.5482114881384,100.441325933803,0.00433704117531697,23158.9514310899,22516.881275472,116.410732832272 -"S3d",17252575,0.46379882125044,53805052917.5154,3118.66796217466,1499.18296255611,2250.29819641196,193882222.110877,11.2378715705266,13.6799532461446,12.5473186435957,110.119655890053,0.00344419663255913,31972.5229532646,31023.6615236639,62.0901757380925 +"S1NoCDAvg",74395846,1,159200698334.965,2139.91382536226,0,2139.91382536226,933196560.713127,12.5436649646401,0,12.5436649646401,0,0,NA,NA,0 +"S1a",74394771,1,180319782952.753,2423.82334845486,0,2423.82334845486,934242430.529448,12.5579045136042,0,12.5579045136042,283.9095230926,0.0142395489640812,19938.0980260508,19674.8879668881,428.067925111391 +"S1b",74384118,1,174899343545.033,2351.29955490005,0,2351.29955490005,933542719.911734,12.5502962865236,0,12.5502962865236,211.385729537788,0.00663132188351767,31876.8615444823,30896.9670850523,120.180364638101 +"S1c",74390209,1,176728465905.913,2375.69524647945,0,2375.69524647945,933496178.014765,12.5486430346602,0,12.5486430346602,235.781421117188,0.00497807002009409,47364.0226363732,45347.3564636064,13.1220798874274 +"S2NoCD",44166055,0.593662917684947,117144112005.875,2652.35624974599,1391.22980800924,2139.91381098032,541887055.653208,12.2693108010939,12.9444991882319,12.5436648803366,0,0,NA,NA,-0.00420079461764544 +"S2a",44161595,0.593602968101203,127021423439.75,2876.28704171011,1391.22980800924,2272.76418973424,542294219.918781,12.2797697845556,12.9444991882319,12.5499138412255,132.850378753921,0.00624896088892868,21259.595173542,21410.3782441873,179.593464897829 +"S3NoCD",34500349,0.463740260444111,99418734053.99,2881.67328550763,1498.46395649551,2139.91381098032,387394494.859054,11.2287123489404,13.680793746073,12.5436648803366,0,0,NA,NA,-0.00420079461764544 +"S3a",34498365,0.463713592288473,105579216551.398,3060.41218334255,1498.46395649551,2222.76057973536,387503366.075873,11.2325139488748,13.680793746073,12.5454931263869,82.8467687550437,0.00182824605033716,45314.8900498188,47016.756345148,8.56133296713233 +"S3b",34505121,0.463804403810396,109490006078.717,3173.15235841998,1498.46395649551,2275.19181231827,387996999.196217,11.2446207389395,13.680793746073,12.5508859769205,135.278001337954,0.00722109658389769,18733.7199781555,18322.3489573076,225.772627062281 +"S3c",34505668,0.463811756371451,107022937523.222,3101.60456894277,1498.46395649551,2242.01941966508,387810722.961726,11.23904405971,13.680793746073,12.5482815354215,102.105608684763,0.004616655084968,22116.7938270335,21287.015126507,128.722944768961 +"S3d",34507875,0.463841422006277,107608997576.599,3118.38957271635,1498.46395649551,2249.85255786778,387745307.909577,11.2364295949715,13.680793746073,12.5469964023249,109.938746887462,0.00333152198833631,32999.5561405144,30673.6737762919,56.6331517347135 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessationceplane_5y.csv b/reproduction/outputs/Sen1_No_Smoking_Cessationceplane_5y.csv index de55622..26c186c 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessationceplane_5y.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessationceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37198402,1,79611221702.1073,2140.17854052191,0,2140.17854052191,466612084.315661,12.5438744469631,0,12.5438744469631,0,0,NA,NA,0 -"S1a",37195208,1,87015658430.0403,2339.43196204307,0,2339.43196204307,466968791.714576,12.5545417494258,0,12.5545417494258,199.253421521165,0.0106673024627,18678.8948956766,20352.8249394169,334.111701613874 -"S1b",37197852,1,85019682450.6848,2285.60731008567,0,2285.60731008567,466815724.569652,12.5495344346672,0,12.5495344346672,145.428769563759,0.00565998770405685,25694.1847169601,30493.8034325589,137.570615638979 -"S1c",37186225,1,85476215420.646,2298.5988876431,0,2298.5988876431,466624752.222822,12.5483227249559,0,12.5483227249559,158.420347121191,0.00444827799278613,35613.8594256259,44640.360839816,63.9935525180772 -"S2NoCD",22087417,0.593773275529417,58618311506.2402,2653.92334043588,1389.24829823251,2140.17854052191,271012140.254789,12.2699788868381,12.9442219723514,12.5438744469631,0,0,NA,NA,0 -"S2a",22083208,0.593660125507542,62093405680.7366,2811.79281926505,1389.24829823251,2233.75625712876,271120515.09004,12.2772250793472,12.9442219723514,12.5482525131374,93.5777166068483,0.00437806617427938,21374.2124677343,21786.5421917709,125.325592107023 -"S3NoCD",17252656,0.463800998763334,49824346254.2723,2887.923242327,1493.39490474986,2140.17854052191,193730581.266238,11.2290293892278,13.6811881114611,12.5438744469631,0,0,NA,NA,0 -"S3a",17243481,0.46355434838303,51742662652.5135,3000.70865346234,1493.39490474986,2192.11674734306,193656912.259667,11.2307319073026,13.6811881114611,12.5452684825013,51.9382068211494,0.00139403553818163,37257.4481773236,66246.2342129985,17.7635700878454 -"S3b",17247748,0.463669057611668,53304765552.954,3090.53480796183,1493.39490474986,2233.93925854614,193842442.780176,11.2387102814916,13.6811881114611,12.5486867178018,93.7607180242344,0.00481227083865576,19483.674374908,20929.0177097903,146.852823908557 -"S3c",17255289,0.463871781373834,52372898312.0746,3035.17943466925,1493.39490474986,2208.58524113819,193880135.434407,11.2359830910051,13.6811881114611,12.546926502798,68.40670061628,0.00305205583487123,22413.3188635346,21176.66202229,84.1960911272326 -"S3d",17249786,0.463723844911402,52605759305.2856,3049.64706839178,1493.39490474986,2215.06614172558,193811770.80811,11.2356043610112,13.6811881114611,12.5471126116496,74.8876012036731,0.00323816468655025,23126.5573102935,24596.8851871209,87.0206331236986 +"S1NoCDAvg",74395846,1,159200698334.965,2139.91382536226,0,2139.91382536226,933196560.713127,12.5436649646401,0,12.5436649646401,0,0,NA,NA,0 +"S1a",74386358,1,174028848972.41,2339.52640849025,0,2339.52640849025,933898758.48662,12.5547047011849,0,12.5547047011849,199.612583127985,0.0110397365447703,18081.2814072583,18392.327010137,352.374244110542 +"S1b",74391545,1,169947664016.912,2284.50241243023,0,2284.50241243023,933536456.1998,12.5489591081863,0,12.5489591081863,144.588587067969,0.00529414354620172,27311.0439500084,28424.0238846907,120.118590242113 +"S1c",74393824,1,171127045500.989,2300.28564603681,0,2300.28564603681,933458732.305095,12.5475299173369,0,12.5475299173369,160.371820674552,0.00386495269680687,41493.8637689012,44006.436191652,32.8758141656872 +"S2NoCD",44157584,0.593549053800665,117261957082.6,2655.53380553157,1386.94284917449,2139.91381098032,541767606.755468,12.268959433004,12.944823150142,12.5436648803366,0,0,NA,NA,-0.00420079461764544 +"S2a",44167644,0.593684276404357,124138133750.894,2810.61253235274,1386.94284917449,2232.15315487099,542293812.182945,12.2780787714859,12.944823150142,12.5489874961528,92.2393438906761,0.00532261581629356,17329.7016118115,17005.4798525458,173.887246129336 +"S3NoCD",34503305,0.463779993845355,99600427723.9674,2886.69238277224,1494.02041376601,2139.91381098032,387416790.773151,11.2283965484799,13.6812485807805,12.5436648803366,0,0,NA,NA,-0.00420079461764544 +"S3a",34502959,0.463775343048051,103657451678.375,3004.3061430869,1494.02041376601,2194.45369598238,387588699.796419,11.2334915911537,13.6812485807805,12.546039243218,54.5398850020615,0.00237436288146498,22970.3241352942,23083.9598108719,64.1740582765779 +"S3b",34499019,0.463722383101874,106572608911.429,3089.14896714682,1494.02041376601,2233.7172278936,387784278.062257,11.2404436213754,13.6812485807805,12.5493926883182,93.8034169132857,0.00572780798169248,16376.8438490091,16805.4585651054,192.582781376666 +"S3c",34498158,0.463710809875057,104673766491.083,3034.18421618576,1494.02041376601,2208.21101792632,387592275.415558,11.2351585674678,13.6812485807805,12.54697019968,68.297206946002,0.00330531934340073,20662.8164635171,21811.804089629,96.9645594293252 +"S3d",34499680,0.46373126800655,104999032656.045,3043.47845127968,1494.02041376601,2212.55255422516,387583597.491654,11.2344113769071,13.6812485807805,12.5465736616227,72.6387432448455,0.00290878128610395,24972.2258568772,26066.5903286192,72.7961202656152 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults.csv b/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults.csv index d974c05..0cbddfd 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,0.414576424546409,0.0774587978268529,0.130292895377603,0.0112390715063513,0.842525131960795,0.0461019085701448,0.0491003989994473,0.0110213130086141,0.00191229417435485,0.186194060423021 -"S1a",1,1,1,0.0264454468360299,0.158359380406053,0.309086725751088,0.0938684682886393,0.401373440658513,0.0753646025550236,0.127161995671021,0.0110095568036926,0.842443868497273,0.0460517274286689,0.0491607809226874,0.0110686165279358,0.00192954195101687,0.464376476791797 -"S1b",1,1,1,0.0216383548237469,0.147534380773731,0.240228427710615,0.0873070792232327,0.406993963766465,0.0763274369301326,0.128610778902023,0.0111314626992498,0.842425567890996,0.0460984402418726,0.0491518214404969,0.0110580698929056,0.00192427062852478,0.333999629803126 -"S1c",1,1,1,0.0201783233063182,0.143831911608648,0.214122624693358,0.084992318136224,0.409279154812625,0.0768345682255774,0.129130951074802,0.0111616296270686,0.842424672770761,0.0460713602497146,0.0491646248526053,0.0110728391960319,0.00192519468853352,0.288509307771604 -"S2NoCD",0.593532888859043,0.58224202899343,0.705569444449141,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,0.414576424546409,0.0774587978268529,0.130292895377602,0.0112390715063513,0.842525131960795,0.0461019085701448,0.0491003989994473,0.0110213130086141,0.00191229417435485,0.186194060423021 -"S2a",0.593475762749163,0.582305124658785,0.705458838857616,0.0223999719282123,0.146108740417515,0.228424810190541,0.08657134879005,0.40740515210631,0.0764552066117195,0.128757466723239,0.0111115672885393,0.842542734688797,0.0460897134449722,0.0490808910111249,0.0110346695973592,0.00191137123114457,0.309928927161259 -"S3NoCD",0.463756588253442,0.415526544326985,0.586756562487125,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,0.414576424546409,0.0774587978268529,0.130292895377603,0.0112390715063513,0.842525131960795,0.0461019085701448,0.0491003989994473,0.0110213130086141,0.00191229417435485,0.186194060423021 -"S3a",0.463706317276748,0.415379456864573,0.586978692022244,0.0201724891280893,0.139182669649564,0.18061459420176,0.0822113440667067,0.411828268680443,0.0772011779928308,0.129862823715872,0.0112297370967753,0.842487355323,0.0461145795875551,0.0491019204489365,0.0110298057657046,0.00192270579825817,0.231159293307654 -"S3b",0.46373548519638,0.415533872887848,0.587106834359327,0.0227387434685853,0.146521606832711,0.232958003609601,0.0870327131350745,0.407378133180258,0.076521014511238,0.12881243857292,0.0111091251255703,0.842489237050869,0.0460946396218897,0.0491013087511228,0.0110452971937639,0.00192941238085603,0.317770312040096 -"S3c",0.463805837680877,0.415603403927939,0.586851957778309,0.0213772593756792,0.142918398689647,0.207204102734025,0.0846795014422536,0.409469478185061,0.0768155464661331,0.129312918698576,0.0111385167932226,0.842522590482225,0.0460943278748357,0.0490880469817344,0.0110316735115724,0.00192444712768483,0.274038001486602 -"S3d",0.46379882125044,0.415599078609114,0.587245606487595,0.0208136426086128,0.141185505125505,0.195300913100731,0.0836057621083008,0.410339860540738,0.0769590190480498,0.129608354246181,0.0111651862765627,0.842477393233695,0.0461184308556459,0.0491177741790075,0.0110249850806031,0.00192229559549136,0.254508030689352 +"S1NoCDAvg",1,1,1,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,0.414823859923577,0.0774716104444864,0.130259994623893,0.0112362590782286,0.842485491998997,0.0461135275232879,0.0491143834985112,0.0110301791002256,0.00191571908774902,0.186025490152701 +"S1a",1,1,1,0.0264236332734017,0.158508229366565,0.309599367787139,0.0937869497099445,0.402103206957919,0.0755534686705333,0.127419761800194,0.0110160564913897,0.842377516199942,0.0460989459861558,0.0491853154956286,0.0110685937112575,0.00192971361751565,0.464468309708502 +"S1b",1,1,1,0.0216557132041627,0.147709336891779,0.240339282715445,0.087535649098251,0.407298531119237,0.0763675385651545,0.128812268769524,0.011117090882223,0.842378827202628,0.046121162421782,0.0491562814893104,0.011069455811699,0.00193066896562442,0.334071604580599 +"S1c",1,1,1,0.0201668879758684,0.143921880619591,0.214150086536029,0.0851948404551918,0.409107910961777,0.076676313679936,0.129220002594696,0.0111515212976482,0.84250560481954,0.046031751332229,0.0491385157411519,0.0110559053230559,0.00192451023591186,0.288333183331823 +"S2NoCD",0.593662917684947,0.58241822916295,0.705150952047846,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,0.414823859923577,0.0774716104444864,0.130259994623893,0.0112362590782286,0.842485491998997,0.0461135275232879,0.0491143834985112,0.0110301791002256,0.00191571908774902,0.186025490152701 +"S2a",0.593602968101203,0.58241402548022,0.705342728682376,0.0224079836515832,0.146109445458714,0.228525350394662,0.0866425414774965,0.407684645652499,0.0764996395734143,0.128891003892322,0.0111278073533347,0.842462613258148,0.0460507065600692,0.0491680235785348,0.0110538810781277,0.00192251639219235,0.310008382503835 +"S3NoCD",0.463740260444111,0.415451055390394,0.586152959630864,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,0.414823859923577,0.0774716104444864,0.130259994623893,0.0112362590782286,0.842485491998997,0.0461135275232879,0.0491143834985112,0.0110301791002256,0.00191571908774902,0.186025490152701 +"S3a",0.463713592288473,0.415410520903306,0.586730765038499,0.0201579517312019,0.139026502119212,0.180388692225143,0.0821315148935111,0.412165641966074,0.0771194642091519,0.129809674672672,0.011207731686269,0.842419878208727,0.0461140947417048,0.0491531978313321,0.0110467384714033,0.00192529186214027,0.230912090044021 +"S3b",0.463804403810396,0.415635446836524,0.587096964653946,0.0227315602197262,0.14623407205971,0.232462301392697,0.0869038618868361,0.408055629179509,0.0763702662446643,0.128678816248485,0.0111235684382867,0.842398812891398,0.0461084418706195,0.049154421812074,0.0110670769913818,0.00193118868859615,0.317545206686976 +"S3c",0.463811756371451,0.415586303111819,0.587102454197951,0.0213684596521233,0.142645328340196,0.206868014690635,0.0845366934160244,0.409850512737668,0.0767430133340044,0.129314313487351,0.0111695612856069,0.842396604947955,0.0461341055318016,0.049153499488423,0.0110503875417815,0.00192691821755138,0.273852461306965 +"S3d",0.463841422006277,0.415577489268392,0.586488320897399,0.0207966965779384,0.141058016136999,0.195070284382104,0.0834918590243405,0.411007003855059,0.076889275897912,0.129526606179602,0.0111702139696136,0.842460541163522,0.0461084531134985,0.049121919701292,0.0110474023654893,0.00192191304695143,0.254325727448637 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults_5y.csv b/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults_5y.csv index a8650b6..0d3a212 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults_5y.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessationclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,0.414576424546409,0.0774587978268529,0.130292895377603,0.0112390715063513,0.842525131960795,0.0461019085701448,0.0491003989994473,0.0110213130086141,0.00191229417435485,0.186194060423021 -"S1a",1,1,1,0.0278481622821389,0.153424995403584,0.272962935489325,0.0908524888175213,0.404923155692529,0.0759127358556511,0.127946696789543,0.0110439495324236,0.842373712824212,0.0460813532994992,0.0491932513106142,0.0110760319300338,0.00193394591287838,0.400244067739566 -"S1b",1,1,1,0.0240916910521861,0.144661245549098,0.215856691551963,0.0855914873414668,0.408646257316148,0.0766199080527553,0.129212595393949,0.0111613434023018,0.84243952631142,0.0461278982107585,0.0491244095792881,0.0110414751449971,0.00192017771575953,0.294432755352329 -"S1c",1,1,1,0.0229832983076723,0.141567962351529,0.195891523021449,0.0835702256997331,0.410612531925464,0.0769541409486981,0.129386217611495,0.0111546950517295,0.842479869321983,0.0460773503993181,0.0491224492044914,0.0110557428214359,0.00192045119965364,0.260234576506399 -"S2NoCD",0.593773275529417,0.582544792958163,0.705150488633886,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,0.414576424546409,0.0774587978268529,0.130292895377603,0.0112390715063513,0.842525131960796,0.0461019085701448,0.0491003989994473,0.0110213130086141,0.00191229417435485,0.186194060423021 -"S2a",0.593660125507542,0.582463274649614,0.705888318123495,0.0214489641842132,0.143461242944309,0.20912219779941,0.0849060590970976,0.409983113465343,0.076795862826274,0.129372209215948,0.0111234375624572,0.84243818553669,0.0460993943899401,0.0491376094364369,0.0110580123656007,0.00192734984684083,0.277796576425682 -"S3NoCD",0.463800998763334,0.415517645651053,0.586900542193213,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,0.414576424546409,0.0774587978268529,0.130292895377602,0.0112390715063513,0.842525131960796,0.0461019085701448,0.0491003989994473,0.0110213130086141,0.00191229417435485,0.186194060423021 -"S3a",0.46355434838303,0.415225779216825,0.585899225724425,0.0198465714460302,0.138053558340149,0.171473875036982,0.0814649457009975,0.412096230750685,0.0770690224492575,0.129783786487954,0.0111966905430231,0.842607861860597,0.046082258357553,0.0490677272672617,0.0109955292444511,0.00190437073144506,0.217302179418445 -"S3b",0.463669057611668,0.415406165077998,0.587559256438161,0.0217857922281613,0.14403586362119,0.212518169672806,0.0853803281486011,0.409099320497244,0.0766787652712796,0.129068313432539,0.0111478520061746,0.842440404626878,0.0461319421996937,0.0491416278785521,0.011023563615533,0.00191870522936732,0.284396292750254 -"S3c",0.463871781373834,0.415605939732743,0.587225345003866,0.0207519161082042,0.140923667243447,0.191421116740374,0.08337272674396,0.41078291901266,0.0769046063335468,0.129482175982632,0.0111860637308477,0.842498306811159,0.046110758930759,0.0491177472605513,0.0110182717810448,0.00191394419568083,0.2494955396648 -"S3d",0.463723844911402,0.415517419703127,0.587194261557275,0.0203061779128958,0.139742750780078,0.18250383844742,0.0825486992411441,0.411549368256723,0.0770272374325198,0.129750746567474,0.0112165887445423,0.842492694549321,0.0461003992548034,0.0491311435192987,0.0110235956059755,0.0019129845059486,0.234642906327591 +"S1NoCDAvg",1,1,1,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,0.414823859923577,0.0774716104444864,0.130259994623893,0.0112362590782286,0.842485491998997,0.0461135275232879,0.0491143834985112,0.0110301791002256,0.00191571908774902,0.186025490152701 +"S1a",1,1,1,0.0278122729795478,0.153448241890984,0.272924851214408,0.0907984352813822,0.404398828075438,0.0757927280160698,0.127990497935119,0.0110865086310584,0.842420503977076,0.046079414543725,0.0491822441960129,0.0110529069378103,0.00192101562795507,0.399962887506169 +"S1b",1,1,1,0.0240695885970156,0.144433469913903,0.215590482867463,0.0853752830448135,0.408936512879253,0.0765706640452218,0.129123168499861,0.0111708124895107,0.842424244151055,0.0461087948691463,0.0491640681667337,0.0110415804255201,0.00191605331833081,0.294331206233115 +"S1c",1,1,1,0.0229702924563115,0.141638722099739,0.195817324843439,0.0837378920106278,0.410807018066446,0.0768670259509714,0.12951688032598,0.0111923941428256,0.842456982557058,0.0461103471447118,0.0491326720681835,0.0110409401916363,0.00191845887661775,0.260138224122077 +"S2NoCD",0.593549053800665,0.582285947877731,0.704572955210663,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,0.414823859923577,0.0774716104444864,0.130259994623893,0.0112362590782286,0.842485491998997,0.0461135275232879,0.0491143834985112,0.0110301791002256,0.00191571908774902,0.186025490152701 +"S2a",0.593684276404357,0.582530316229979,0.705472471504752,0.0214502318921747,0.143116925335182,0.208748349714574,0.0847760986361914,0.410213760850193,0.0767835908183059,0.129228258177031,0.0111333227992911,0.842408227276434,0.0461224523728785,0.04914920381173,0.0110491068683517,0.00192994720696256,0.277642108609294 +"S3NoCD",0.463779993845355,0.415480534930995,0.586885701047501,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,0.414823859923577,0.0774716104444864,0.130259994623893,0.0112362590782286,0.842485491998997,0.0461135275232879,0.0491143834985112,0.0110301791002256,0.00191571908774902,0.186025490152701 +"S3a",0.463775343048051,0.415546287905802,0.586475817070161,0.019825541262314,0.137948991357484,0.17152126846143,0.0813847161100176,0.412680083278406,0.0771648247595408,0.129864923614523,0.0112170474480284,0.8425337388547,0.0460773453520565,0.049077865350205,0.0110496593850659,0.00191867170840166,0.217272420127309 +"S3b",0.463722383101874,0.415522539824454,0.587001916738041,0.0217641653047701,0.14362506475593,0.212127273131077,0.0851967872667717,0.40922751248836,0.0766039029473366,0.129054825732769,0.0111541694579512,0.842474027940877,0.0460883212264744,0.0491107664899512,0.011057148435474,0.00192710337814214,0.284195787098864 +"S3c",0.463710809875057,0.415431748823674,0.586550786030388,0.0207094882970829,0.140742502682869,0.191538518912958,0.0832853342719402,0.410839869649574,0.0768743325036871,0.12948003808332,0.0111750013291636,0.84251557420843,0.0460916594519629,0.0490916629186117,0.0110393453044877,0.00191795828760873,0.249487018174973 +"S3d",0.46373126800655,0.41547916142502,0.586634808584703,0.0202885512414083,0.139327223616881,0.182177787629984,0.0823358025531667,0.411454907385373,0.076917022734159,0.129578216426904,0.0111899748974614,0.842510268040298,0.046082665711685,0.0490966137544137,0.0110497886404174,0.00191611642094193,0.234466839327561 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessations1.csv b/reproduction/outputs/Sen1_No_Smoking_Cessations1.csv index 603f9cf..21b8942 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessations1.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessations1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37204854,626018224.940456,71202557.0391507,190989723,13185985.8433274,13393668,0.0171940876216492,0.135414811265986,0.151213211659668,0.0796491535795988,15418908,2881539,4847882,418531,0.21654991956991,0.0404695999669729,0.0680857851401937,0.0058780332814434,527413624,28872284,30752411,6896116,1196927,79594247521.0896,2139.35115888614,466658875.012662,12.5429567607673,625008.486879481,0,0,NA,0 -"S1NoCD2",37191950,625889055.908563,71140468.187672,124648922,13317439.9965512,16364556,0.0209155472275561,0.135478793259558,0.151449991953223,0.0796920823572567,15424253,2881148,4845493,417620,0.216814049625174,0.0404994242151934,0.0681116265248263,0.00587035776737227,527349723,28843031,30716736,6901546,1197088,79628195883.1249,2141.00620922336,466565293.61866,12.5447924515563,625098.616368592,0,0,NA,0 -"S1NoCDAvg",37198402,625953640.424509,71171512.6134114,157819322.5,13251712.9199393,14879112,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,15421580.5,2881343.5,4846687.5,418075.5,0.216681984597542,0.0404845120910832,0.06809870583251,0.00587419552440783,527381673.5,28857657.5,30734573.5,6898831,1197007.5,79611221702.1073,2140.17854052191,466612084.315661,12.5438744469631,625053.551624037,0,0,NA,0 -"S1a",37192142,625969287.355205,71224394.3187244,186049005,33074933.295359,13391900,0.0264454468360299,0.158359380406053,0.309086725751088,0.0938684682886393,14927938,2802971,4729427,409469,0.209590241416424,0.0393540868519975,0.0664017861469784,0.00574899939713989,527343988,28826967,30773139,6928614,1207834,90029166180.6185,2420.6502056434,467067251.851173,12.5582240423575,625490.55191223,281.29904675726,0.0152672815901305,18424.9596168519,482.065032749204 -"S1b",37187925,625865188.683616,71225581.8193521,188347039,23789317.9601759,13384883,0.0216383548237469,0.147534380773731,0.240228427710615,0.0873070792232327,15135261,2838459,4782768,413956,0.21249754109959,0.0398516786735294,0.0671495813418615,0.00581190057597434,527244837,28851409,30762414,6920861,1204334,87358830750.2865,2349.1181815142,466782406.198794,12.5519884800992,625250.305823447,209.767022628062,0.00903171933188318,23225.5913763347,241.818943965947 -"S1c",37195823,625981365.509578,71238478.0994062,189184178,20552964.0031623,13386224,0.0201783233063182,0.143831911608648,0.214122624693358,0.084992318136224,15223475,2857925,4803132,415166,0.213697364207545,0.0401177155414809,0.0674232820260099,0.00582783365221078,527342147,28839813,30776139,6931391,1205136,88369606438.0401,2375.79382066745,466792527.490138,12.5495953534927,625103.973853969,236.442661781306,0.00663859272539291,35616.3831043441,95.4869744882453 +"S1NoCD",74397625,1251888615.40556,142400097.482606,381936924,26358453.5447083,26783324,0.0171958287073828,0.135249588369982,0.151090722821903,0.0795795155775136,30847754,5758388,9691126,836590,0.216627337658726,0.0404380902948706,0.0680556135236055,0.00587492575348965,1054688429,57727616,61505481,13799186,2398591,159124648209.342,2138.84042950755,933200650.811072,12.5434199117387,625032.155157429,0,0,NA,0 +"S1NoCD2",74394066,1251871998.91076,142377758.272772,249324170,26617486.656821,32718146,0.0208987811075114,0.135317679730024,0.151191180138899,0.0795269416588485,30874590,5768744,9690479,835272,0.216849811196279,0.0405171711507641,0.0680617472669761,0.00586659047124313,1054693564,57729618,61465178,13817742,2397911,159276748460.588,2140.98727256806,933192470.615182,12.5439100292647,625054.514190668,0,0,NA,0 +"S1NoCDAvg",74395846,1251880307.15816,142388927.877689,315630547,26487970.1007647,29750735,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,30861172,5763566,9690802.5,835931,0.216738574427502,0.0404776307228173,0.0680586803952908,0.00587075811236639,1054690996.5,57728617,61485329.5,13808464,2398251,159200698334.965,2139.91382536226,933196560.713127,12.5436649646401,625043.334674049,0,0,NA,0 +"S1a",74394771,1252091490.71075,142557437.697903,372128624,66213412.1239201,26771781,0.0264236332734017,0.158508229366565,0.309599367787139,0.0937869497099445,29914376,5620783,9479364,819537,0.209840864728449,0.0394281988422879,0.0664950503676135,0.00574881965637388,1054733720,57720098,61584515,13858892,2416178,180319782952.753,2423.82334845486,934242430.529448,12.5579045136042,625471.402331753,284.982918947312,0.0144846018654299,19674.8879668881,439.247174324119 +"S1b",74384118,1251703447.36878,142505866.677027,376679454,47607163.5429435,26787921,0.0216557132041627,0.147709336891779,0.240339282715445,0.087535649098251,30296542,5680532,9581587,826935,0.212598559669571,0.0398617413616679,0.0672364389159888,0.00580281373169113,1054408482,57730018,61529087,13855676,2416625,174899343545.033,2351.29955490005,933542719.911734,12.5502962865236,625163.51477128,212.4591253925,0.00687637478486636,30896.9670850523,131.359613850829 +"S1c",74390209,1251828104.12983,142354151.917186,378340031,41045425.7827844,26779722,0.0201668879758684,0.143921880619591,0.214150086536029,0.0851948404551918,30433623,5703967,9612703,829564,0.213788095325133,0.0400688488757127,0.0675266781512078,0.00582746613869466,1054672194,57623840,61512975,13840093,2409156,176728465905.913,2375.69524647945,933496178.014765,12.5486430346602,625056.456486529,236.854816971899,0.00522312292144278,45347.3564636064,24.3013291001553 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessations1_5y.csv b/reproduction/outputs/Sen1_No_Smoking_Cessations1_5y.csv index e008f65..ac5378e 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessations1_5y.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessations1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37204854,626018224.940456,71202557.0391507,190989723,13185985.8433274,13393668,0.0171940876216492,0.135414811265986,0.151213211659668,0.0796491535795988,15418908,2881539,4847882,418531,0.21654991956991,0.0404695999669729,0.0680857851401937,0.0058780332814434,527413624,28872284,30752411,6896116,1196927,79594247521.0896,2139.35115888614,466658875.012662,12.5429567607673,625008.486879481,0,0,NA,0 -"S1NoCD",37191950,625889055.908563,71140468.187672,124648922,13317439.9965512,16364556,0.0209155472275561,0.135478793259558,0.151449991953223,0.0796920823572567,15424253,2881148,4845493,417620,0.216814049625174,0.0404994242151934,0.0681116265248263,0.00587035776737227,527349723,28843031,30716736,6901546,1197088,79628195883.1249,2141.00620922336,466565293.61866,12.5447924515563,625098.616368592,0,0,NA,0 -"S1NoCDAvg",37198402,625953640.424509,71171512.6134114,157819322.5,13251712.9199393,14879112,0.0190548174246026,0.135446802262772,0.151331601806446,0.0796706179684278,15421580.5,2881343.5,4846687.5,418075.5,0.216681984597542,0.0404845120910832,0.06809870583251,0.00587419552440783,527381673.5,28857657.5,30734573.5,6898831,1197007.5,79611221702.1073,2140.17854052191,466612084.315661,12.5438744469631,625053.551624037,0,0,NA,0 -"S1a",37195208,625981312.061716,71272709.8742139,122751743,28526479.3188773,16361764,0.0278481622821389,0.153424995403584,0.272962935489325,0.0908524888175213,15061201,2823590,4759004,410782,0.211317922758667,0.0396167060994766,0.0667717560956916,0.00576352436612795,527310202,28846066,30794056,6933389,1210614,87015658430.0403,2339.43196204307,466968791.714576,12.5545417494258,625387.655509247,198.425752819711,0.00974929786947776,20352.8249394169,289.039140654262 -"S1b",37197852,625993620.348071,71228378.223709,123724740,20971967.6596844,16356344,0.0240916910521861,0.144661245549098,0.215856691551963,0.0855914873414668,15200763,2850096,4806431,415178,0.213408803893562,0.0400134900032207,0.0674791581650828,0.00582882848597281,527361769,28875770,30751567,6911893,1202019,85019682450.6848,2285.60731008567,466815724.569652,12.5495344346672,625191.114423272,144.601100862305,0.00474198311083462,30493.8034325589,92.4980546793668 -"S1c",37186225,625816474.907958,71183273.7777319,123996885,18524349.1058871,16346258,0.0229832983076723,0.141567962351529,0.195891523021449,0.0835702256997331,15269130,2861634,4811385,414801,0.214504464176198,0.0402009327210123,0.0675915105425389,0.00582722566673748,527237782,28835965,30741638,6918866,1201850,85476215420.646,2298.5988876431,466624752.222822,12.5483227249559,625117.537360151,157.592678419737,0.00353027339956391,44640.360839816,18.9209915584652 +"S1NoCD2",74397625,1251888615.40556,142400097.482606,381936924,26358453.5447083,26783324,0.0171958287073828,0.135249588369982,0.151090722821903,0.0795795155775136,30847754,5758388,9691126,836590,0.216627337658726,0.0404380902948706,0.0680556135236055,0.00587492575348965,1054688429,57727616,61505481,13799186,2398591,159124648209.342,2138.84042950755,933200650.811072,12.5434199117387,625032.155157429,0,0,NA,0 +"S1NoCD",74394066,1251871998.91076,142377758.272772,249324170,26617486.656821,32718146,0.0208987811075114,0.135317679730024,0.151191180138899,0.0795269416588485,30874590,5768744,9690479,835272,0.216849811196279,0.0405171711507641,0.0680617472669761,0.00586659047124313,1054693564,57729618,61465178,13817742,2397911,159276748460.588,2140.98727256806,933192470.615182,12.5439100292647,625054.514190668,0,0,NA,0 +"S1NoCDAvg",74395846,1251880307.15816,142388927.877689,315630547,26487970.1007647,29750735,0.0190473049074471,0.135283634050003,0.151140951480401,0.0795532286181811,30861172,5763566,9690802.5,835931,0.216738574427502,0.0404776307228173,0.0680586803952908,0.00587075811236639,1054690996.5,57728617,61485329.5,13808464,2398251,159200698334.965,2139.91382536226,933196560.713127,12.5436649646401,625043.334674049,0,0,NA,0 +"S1a",74386358,1251896634.78169,142473655.594415,245503789,56984174.6851017,32705395,0.0278122729795478,0.153448241890984,0.272924851214408,0.0907984352813822,30081756,5637945,9520747,824685,0.211139076024236,0.0395718420818074,0.0668246137173813,0.00578833326455567,1054623394,57686664,61571086,13837097,2404913,174028848972.41,2339.52640849025,933898758.48662,12.5547047011849,625395.708650753,198.53913592219,0.0107946719201308,18392.327010137,341.194460084429 +"S1b",74391545,1251861822.97349,142462209.38612,247434066,41931073.9312515,32705922,0.0240695885970156,0.144433469913903,0.215590482867463,0.0853752830448135,30421419,5696210,9605672,831014,0.213540272406893,0.0399840071591292,0.067426105781958,0.00583322414822077,1054598750,57721840,61546620,13822533,2398634,169947664016.912,2284.50241243023,933536456.1998,12.5489591081863,625163.452996884,143.515139862174,0.00504907892156226,28424.0238846907,108.938806216 +"S1c",74393824,1251906428.2651,142431704.901555,248055301,37051930.7717703,32690365,0.0229702924563115,0.141638722099739,0.195817324843439,0.0837378920106278,30561505,5718432,9635256,832645,0.214569537176595,0.0401485891357716,0.0676482529410122,0.00584592454731551,1054677312,57725840,61509508,13822224,2401731,171127045500.989,2300.28564603681,933458732.305095,12.5475299173369,625076.210220808,159.298373468757,0.0036198880721674,44006.436191652,21.6960301395738 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessations2.csv b/reproduction/outputs/Sen1_No_Smoking_Cessations2.csv index 3634f4b..4cb68c1 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessations2.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessations2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078475,364456517.65659,50216444.6152497,110945016,9669471.97880161,7747302,0.0172763187293212,0.141468940724062,0.159172160434852,0.0871643552623369,11485953,2127051,3548098,303898,0.228728917150617,0.0423576582591046,0.0706560973638209,0.00605176257157227,298681487,18624314,22530486,5565392,1033338,58623262797.6865,2655.22246430908,270860548.807215,12.268082320324,610748.893551889,0,0,NA,0 -"S2a",22076350,364496012.618014,50208572.6479974,108779574,18474523.9052724,7734901,0.023021456417017,0.156585627680087,0.268457280298273,0.0969502499649857,11218640,2089613,3490800,299139,0.223440727515831,0.0416186497602685,0.0695259756630272,0.00595792678866228,298727047,18618226,22519514,5573954,1032785,63456641764.5573,2874.4172729893,271102266.321126,12.2802123684905,611136.201151538,219.194808680214,0.0121300481665791,18070.39886982,387.307599648717 +"S2NoCD",44166055,729117911.619028,100405688.054024,221954036,19343537.4086331,15478949,0.0172677031834835,0.141307805640671,0.159020339956761,0.087068332370569,22957271,4249333,7089574,607905,0.228645124045637,0.0423216361777591,0.0706092865593966,0.00605448766680339,597585749,37297625,44999354,11122450,2059355,117144112005.875,2652.35624974599,541887055.653208,12.2693108010939,610813.18380495,0,0,NA,0 +"S2a",44161595,729112649.111399,100432994.923407,217571137,37001975.4298114,15492083,0.0230379296587062,0.156650549966554,0.268724843641739,0.0971122791982347,22424977,4176799,6987343,599803,0.223282966091989,0.0415879164330939,0.069572185966661,0.0059721708036032,597552506,37218775,45066339,11152095,2067861,127021423439.75,2876.28704171011,542294219.918781,12.2797697845556,611112.202186069,223.930791964115,0.0104589834616728,21410.3782441873,299.018381119589 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessations2_5y.csv b/reproduction/outputs/Sen1_No_Smoking_Cessations2_5y.csv index de75642..c7087e0 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessations2_5y.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessations2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22087417,364646033.862504,50186626.8961598,72526119,9746775.33878268,9462789,0.0209497676599648,0.141521596875195,0.159221468171808,0.0872212806913073,11464621,2124260,3543653,304619,0.228439759932885,0.0423272120757442,0.0706095073361298,0.00606972452303443,298890008,18629794,22515326,5556637,1022110,58618311506.2402,2653.92334043588,271012140.254789,12.2699788868381,610845.021001469,0,0,NA,0 -"S2a",22083208,364595007.180507,50239139.3369861,71692048,16275035.6947752,9453921,0.0250607852967275,0.152853756580684,0.241062817518018,0.0946113256399238,11292655,2099389,3509042,300286,0.22477803459675,0.0417879173032415,0.069846777757529,0.00597713264922374,298790965,18626223,22537013,5579347,1031500,62093405680.7366,2811.79281926505,271120515.09004,12.2772250793472,611049.461148094,157.869478829174,0.00724619250909875,21786.5421917709,204.44014662574 +"S2NoCD",44157584,728952311.283056,100323387.704061,144982166,19523087.5794101,18911929,0.0209492764642343,0.141811702826159,0.159601190203368,0.0873978905645692,22913196,4246236,7091076,607396,0.228393363944113,0.0423254845871608,0.0706821825127916,0.00605438087668776,597502927,37198908,45025648,11128697,2049374,117261957082.6,2655.53380553157,541767606.755468,12.268959433004,610792.43784467,0,0,NA,0 +"S2a",44167644,729258231.210927,100451468.864785,143393557,32589486.3321875,18909118,0.0250723482405978,0.152887137993859,0.241222572786426,0.0947673979522638,22572868,4195555,7015184,599814,0.22471416550797,0.0417669850666646,0.0698365497217661,0.00597118197253435,597673662,37222091,45078868,11153960,2067390,124138133750.894,2810.61253235274,542293812.182945,12.2780787714859,611093.32604194,155.078726821173,0.00911933848182223,17005.4798525458,300.888197269873 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessations3.csv b/reproduction/outputs/Sen1_No_Smoking_Cessations3.csv index 47ec85c..7ec73f1 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessations3.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessations3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17251004,260100353.114493,41760352.0880543,80093301,7808219.70487016,5817970,0.0184150314982946,0.136511732675845,0.15365363320101,0.0860226423966545,9778778,1815130,3033059,260471,0.234164165555425,0.0434653902383937,0.0726301108190996,0.00623727978755497,207449252,15297713,18728772,4824301,894240,49706422473.1814,2881.36403383718,193732612.293423,11.2302224434834,558629.758140335,0,0,NA,0 -"S3a",17249134,260008283.181935,41776161.3830648,79278529,11011389.3692548,5822190,0.0211053684365486,0.142875328166845,0.203539165058558,0.0903453064859476,9676022,1805447,3016891,260109,0.23161587086176,0.0432171587869222,0.0722156105329243,0.00622625419350862,207345092,15302232,18726703,4829095,900681,52783263534.7295,3060.05295887489,193741259.214591,11.2319412217791,558537.008130078,178.688925037707,0.00171877829560785,103962.753948155,-92.7500102572376 -"S3b",17250219,260104940.453844,41785281.4670249,77779970,17177314.5500211,5822903,0.027280576057851,0.15537355009899,0.292681879568769,0.0985530894238149,9510791,1780204,2977917,255631,0.227611031111649,0.0426036139401109,0.0712671279323568,0.00611772832502595,207430795,15293333,18729492,4839340,904959,54744732216.0787,3173.56737419268,193956703.474523,11.2437241216777,559012.638709692,292.2033403555,0.0135016781942525,21642.0015461401,382.880569357309 -"S3c",17252836,260148463.661511,41767141.515224,78572238,14061462.4689268,5825793,0.0240033545544673,0.149242968371158,0.24885986734078,0.0945553175844739,9589326,1791300,2996772,256745,0.229590191047781,0.0428877805618341,0.0717495114887784,0.00614705700907056,207489733,15294751,18722619,4831059,901887,53445425795.8674,3097.77626100818,193919004.9689,11.2398335536778,558893.90142288,216.412227171001,0.00961111019432082,22516.881275472,264.143282545032 -"S3d",17252575,260145756.212447,41795158.0893023,78912696,12676670.2855603,5832474,0.0226472463255341,0.146281822959203,0.228522755848803,0.0927108609727969,9621629,1796623,3007738,257735,0.230209178284283,0.0429863908197504,0.0719637904843778,0.00616662340286658,207459074,15309738,18741138,4826857,900538,53805052917.5154,3118.66796217466,193882222.110877,11.2378715705266,558774.910564154,237.303928337474,0.00764912704312692,31023.6615236639,145.152423818945 +"S3NoCD",34500349,520094994.831309,83461691.4941729,160143901,15618827.8956296,11654651,0.018427161207504,0.136610098091257,0.153827585473126,0.0860480213133546,19547537,3636418,6069919,520617,0.234209691297291,0.0435699053649528,0.0727270067420547,0.00623779593583181,414853261,30586952,37418093,9635730,1793033,99418734053.99,2881.67328550763,387394494.859054,11.2287123489404,558553.944161513,0,0,NA,0 +"S3a",34498365,520044250.505163,83543964.586688,158570002,22025358.0209284,11641972,0.0211006703391431,0.142986133418066,0.203669849522932,0.0904268923761054,19349214,3610114,6036237,518479,0.231605168556762,0.0432121460581874,0.0722522210893714,0.00620606171331513,414726752,30585780,37465015,9656171,1804975,105579216551.398,3060.41218334255,387503366.075873,11.2325139488748,558565.285260395,178.738897834914,0.00380159993434681,47016.756345148,11.3410988823744 +"S3b",34505121,520325830.851528,83596107.3573207,155591308,34370572.3643698,11646287,0.0272917827402887,0.155256783290561,0.292331489370406,0.0985430924438279,19045362,3554737,5952719,512271,0.227825943121886,0.0425227574868497,0.0712080883689461,0.00612792887365394,414946581,30589147,37475808,9683238,1812590,109490006078.717,3173.15235841998,387996999.196217,11.2446207389395,559057.884588555,291.479072912342,0.0159083899990939,18322.3489573076,503.940427042311 +"S3c",34505668,520264308.790349,83596889.0076061,157131912,28149353.3692508,11644831,0.0240127596995942,0.149143942762032,0.248735891226273,0.0945108776278229,19179049,3582497,6000047,515697,0.229422999201023,0.0428544296627359,0.0717735680266054,0.00616885396241335,414890025,30618993,37472630,9661994,1807193,107022937523.222,3101.60456894277,387810722.961726,11.23904405971,558850.598416558,219.931283435141,0.0103317107695986,21287.015126507,296.654255044647 +"S3d",34507875,520253274.913333,83509443.2253667,157815894,25352833.275711,11646210,0.02263702783514,0.146453955130063,0.228726188259577,0.0927546635528788,19265713,3593496,6016041,515763,0.230701011237827,0.0430310137537649,0.0720402479964395,0.00617610392405697,414960418,30586470,37432733,9658194,1800918,107608997576.599,3118.38957271635,387745307.909577,11.2364295949715,558703.090175858,236.716287208715,0.00771724603107948,30673.6737762919,149.146014345228 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessations3_5y.csv b/reproduction/outputs/Sen1_No_Smoking_Cessations3_5y.csv index 93319e5..830b680 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessations3_5y.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessations3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17252656,260094782.955898,41770599.3415222,52444190,7909134.93517632,7072687,0.0221913733157189,0.136774814350276,0.154200676860758,0.0861604267298537,9782958,1820515,3040238,260475,0.234206790283596,0.0435836456430806,0.0727841603406882,0.00623584540576782,207435240,15306525,18721148,4829059,898040,49824346254.2723,2887.923242327,193730581.266238,11.2290293892278,558563.546219064,0,0,NA,0 -"S3a",17243481,259912088.098875,41699334.1338339,52142253,10110196.883167,7079583,0.0241019490267343,0.141229462771659,0.188590938409989,0.0892497949595453,9688105,1805528,3020469,258826,0.23233236696073,0.0432987249677696,0.0724344659870543,0.00620695762597309,207327257,15287458,18694698,4811886,892931,51742662652.5135,3000.70865346234,193656912.259667,11.2307319073026,558535.886711669,112.785411135346,0.00170251807480426,66246.2342129985,-27.659507395234 -"S3b",17247748,260025001.285357,41817481.0307152,51563538,14906855.4437668,7078800,0.028767041374099,0.151389414770136,0.258329736640104,0.0958604896443194,9577831,1791238,2994241,257043,0.229038927355883,0.0428346699956491,0.0716026151312345,0.00614678344234078,207321180,15322740,18744664,4830073,901996,53304765552.954,3090.53480796183,193842442.780176,11.2387102814916,558844.979266617,202.611565634827,0.00968089226376101,20929.0177097903,281.433047553175 -"S3c",17255289,260150050.95776,41793716.0488575,51902628,12418597.6089005,7087241,0.0262736654621587,0.146099719800887,0.222466223369234,0.0924561463237565,9642590,1800040,3010319,258524,0.230718656094798,0.0430696327145384,0.0720280292013491,0.00618571461072716,207466781,15314112,18733822,4827468,899118,52372898312.0746,3035.17943466925,193880135.434407,11.2359830910051,558763.975115588,147.256192342254,0.00695370177732713,21176.66202229,200.428896524012 -"S3d",17249786,260094641.522971,41791503.7929464,52022800,11361111.228591,7083958,0.0252029479007513,0.144089266421316,0.207283955649464,0.0910539809044321,9669545,1804309,3019811,259616,0.231375856870507,0.0431740625783495,0.0722589695494443,0.00621217176788499,207414812,15305575,18740388,4830487,898472,52605759305.2856,3049.64706839178,193811770.80811,11.2356043610112,558730.570982169,161.723826064785,0.00657497178339739,24596.8851871209,167.024763104971 +"S3NoCD",34503305,520131899.687652,83566025.7588996,104876864,15818112.8965564,14153690,0.0222342080640183,0.136857295699243,0.154149401616996,0.0861839237649901,19571024,3639873,6075336,520651,0.234198333859568,0.0435568518060387,0.0727010282567254,0.00623041475613733,414791492,30617496,37480217,9639095,1796669,99600427723.9674,2886.69238277224,387416790.773151,11.2283965484799,558533.135041225,0,0,NA,0 +"S3a",34502959,520214214.54195,83507662.8188118,104354722,20256743.3301919,14160507,0.0241061484006248,0.141404659096601,0.188904972628611,0.08931801094331,19411438,3617031,6045913,519219,0.232450979284588,0.0433137616106913,0.0723994995898513,0.00621762102391202,414923874,30575250,37437201,9663951,1800433,103657451678.375,3004.3061430869,387588699.796419,11.2334915911537,558670.273414596,117.613760314655,0.00509504267371241,23083.9598108719,137.138373370981 +"S3b",34499019,520184484.786577,83582573.5864781,103156699,29799477.8304381,14153270,0.0287720757339342,0.151066768908409,0.258042546743686,0.0957949542686882,19153466,3575091,5985288,514510,0.22915621257083,0.0427731624738865,0.0716092810160645,0.00615570899438345,414823125,30587889,37477414,9673157,1810964,106572608911.429,3089.14896714682,387784278.062257,11.2404436213754,558933.032101621,202.456584374581,0.0120470728954079,16805.4585651054,399.897060395801 +"S3c",34498158,520070825.320634,83518337.5686826,103759249,24845681.6958237,14164602,0.0262359469412221,0.1461661987692,0.22302665379869,0.092555888988756,19273175,3595164,6016844,516053,0.230765788221663,0.0430464027979899,0.0720421906752149,0.0061789184869205,414775743,30587857,37449770,9650222,1799422,104673766491.083,3034.18421618576,387592275.415558,11.2351585674678,558723.744157204,147.491833413522,0.00676201898785855,21811.804089629,190.609115979285 +"S3d",34499680,520130180.22257,83530301.4501091,104037313,22709144.6557611,14168991,0.0252217317181545,0.143751781371509,0.20705908714278,0.0909340695902395,19319362,3598421,6024286,517179,0.23128567315825,0.0430792291842651,0.0721209656306362,0.00619151363064217,414821005,30578797,37457915,9663634,1797165,104999032656.045,3043.47845127968,387583597.491654,11.2344113769071,558677.090394075,156.786068507439,0.00601482842714951,26066.5903286192,143.955352850026 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessationsall.csv b/reproduction/outputs/Sen1_No_Smoking_Cessationsall.csv index 10f64e0..51ee8b0 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessationsall.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessationsall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37192142,90029166180.6185,2420.6502056434,467067251.851173,12.5582240423575,18424.9596168519,482.065032749204 -"S2a",22076350,63456641764.5573,2874.4172729893,271102266.321126,12.2802123684905,18070.39886982,387.307599648717 -"S3b",17250219,54744732216.0787,3173.56737419268,193956703.474523,11.2437241216777,21642.0015461401,382.880569357309 -"S3c",17252836,53445425795.8674,3097.77626100818,193919004.9689,11.2398335536778,22516.881275472,264.143282545032 -"S1b",37187925,87358830750.2865,2349.1181815142,466782406.198794,12.5519884800992,23225.5913763347,241.818943965947 -"S3d",17252575,53805052917.5154,3118.66796217466,193882222.110877,11.2378715705266,31023.6615236639,145.152423818945 -"S1c",37195823,88369606438.0401,2375.79382066745,466792527.490138,12.5495953534927,35616.3831043441,95.4869744882453 -"S1NoCD",37204854,79594247521.0896,2139.35115888614,466658875.012662,12.5429567607673,NA,0 -"S2NoCD",22078475,58623262797.6865,2655.22246430908,270860548.807215,12.268082320324,NA,0 -"S3NoCD",17251004,49706422473.1814,2881.36403383718,193732612.293423,11.2302224434834,NA,0 -"S3a",17249134,52783263534.7295,3060.05295887489,193741259.214591,11.2319412217791,103962.753948155,-92.7500102572376 +"S3b",34505121,109490006078.717,3173.15235841998,387996999.196217,11.2446207389395,18322.3489573076,503.940427042311 +"S1a",74394771,180319782952.753,2423.82334845486,934242430.529448,12.5579045136042,19674.8879668881,439.247174324119 +"S2a",44161595,127021423439.75,2876.28704171011,542294219.918781,12.2797697845556,21410.3782441873,299.018381119589 +"S3c",34505668,107022937523.222,3101.60456894277,387810722.961726,11.23904405971,21287.015126507,296.654255044647 +"S3d",34507875,107608997576.599,3118.38957271635,387745307.909577,11.2364295949715,30673.6737762919,149.146014345228 +"S1b",74384118,174899343545.033,2351.29955490005,933542719.911734,12.5502962865236,30896.9670850523,131.359613850829 +"S1c",74390209,176728465905.913,2375.69524647945,933496178.014765,12.5486430346602,45347.3564636064,24.3013291001553 +"S3a",34498365,105579216551.398,3060.41218334255,387503366.075873,11.2325139488748,47016.756345148,11.3410988823744 +"S1NoCD",74397625,159124648209.342,2138.84042950755,933200650.811072,12.5434199117387,NA,0 +"S2NoCD",44166055,117144112005.875,2652.35624974599,541887055.653208,12.2693108010939,NA,0 +"S3NoCD",34500349,99418734053.99,2881.67328550763,387394494.859054,11.2287123489404,NA,0 diff --git a/reproduction/outputs/Sen1_No_Smoking_Cessationsall_5y.csv b/reproduction/outputs/Sen1_No_Smoking_Cessationsall_5y.csv index 8b98d31..91e80a9 100644 --- a/reproduction/outputs/Sen1_No_Smoking_Cessationsall_5y.csv +++ b/reproduction/outputs/Sen1_No_Smoking_Cessationsall_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37195208,87015658430.0403,2339.43196204307,466968791.714576,12.5545417494258,20352.8249394169,289.039140654262 -"S3b",17247748,53304765552.954,3090.53480796183,193842442.780176,11.2387102814916,20929.0177097903,281.433047553175 -"S2a",22083208,62093405680.7366,2811.79281926505,271120515.09004,12.2772250793472,21786.5421917709,204.44014662574 -"S3c",17255289,52372898312.0746,3035.17943466925,193880135.434407,11.2359830910051,21176.66202229,200.428896524012 -"S3d",17249786,52605759305.2856,3049.64706839178,193811770.80811,11.2356043610112,24596.8851871209,167.024763104971 -"S1b",37197852,85019682450.6848,2285.60731008567,466815724.569652,12.5495344346672,30493.8034325589,92.4980546793668 -"S1c",37186225,85476215420.646,2298.5988876431,466624752.222822,12.5483227249559,44640.360839816,18.9209915584652 -"S1NoCD",37191950,79628195883.1249,2141.00620922336,466565293.61866,12.5447924515563,NA,0 -"S2NoCD",22087417,58618311506.2402,2653.92334043588,271012140.254789,12.2699788868381,NA,0 -"S3NoCD",17252656,49824346254.2723,2887.923242327,193730581.266238,11.2290293892278,NA,0 -"S3a",17243481,51742662652.5135,3000.70865346234,193656912.259667,11.2307319073026,66246.2342129985,-27.659507395234 +"S3b",34499019,106572608911.429,3089.14896714682,387784278.062257,11.2404436213754,16805.4585651054,399.897060395801 +"S1a",74386358,174028848972.41,2339.52640849025,933898758.48662,12.5547047011849,18392.327010137,341.194460084429 +"S2a",44167644,124138133750.894,2810.61253235274,542293812.182945,12.2780787714859,17005.4798525458,300.888197269873 +"S3c",34498158,104673766491.083,3034.18421618576,387592275.415558,11.2351585674678,21811.804089629,190.609115979285 +"S3d",34499680,104999032656.045,3043.47845127968,387583597.491654,11.2344113769071,26066.5903286192,143.955352850026 +"S3a",34502959,103657451678.375,3004.3061430869,387588699.796419,11.2334915911537,23083.9598108719,137.138373370981 +"S1b",74391545,169947664016.912,2284.50241243023,933536456.1998,12.5489591081863,28424.0238846907,108.938806216 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--git a/reproduction/outputs/Sen2_50_Med_Adherenceceplane.csv b/reproduction/outputs/Sen2_50_Med_Adherenceceplane.csv index 15cb844..9d8264b 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherenceceplane.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherenceceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466645458.453711,12.5452260864825,0,12.5452260864825,0,0,NA,NA,0 -"S1a",37195779,1,90753454325.5885,2439.88583558335,0,2439.88583558335,467242137.557907,12.5616978624888,0,12.5616978624888,291.045221313176,0.0164717760063304,17669.3285047903,17116.0871029401,532.543579003308 -"S1b",37200476,1,87878153021.8125,2362.2857143498,0,2362.2857143498,466988044.397164,12.5532814256776,0,12.5532814256776,213.445100079627,0.00805533919506018,26497.3447934407,24764.4612846515,189.321859673364 -"S1c",37192813,1,88797560537.4716,2387.49245821959,0,2387.49245821959,466783360.164217,12.5503645062883,0,12.5503645062883,238.651843949422,0.00513841980577467,46444.5983337562,41646.3318169583,18.2691463392694 -"S2NoCD",22078563,0.593556763930821,58731887920.9201,2660.13181749736,1402.16728772077,2148.84064315472,270917817.912949,12.270627300923,12.9462418266983,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S2a",22077788,0.593535928947491,63840415722.8595,2891.61286098315,1402.16728772077,2286.20674966379,271190365.071176,12.2834028966659,12.9462418266983,12.552823106619,137.366106509064,0.00759685150450196,18081.9786233362,18119.0018958139,242.484871430788 -"S3NoCD",17243525,0.463572330217334,49933527333.6569,2895.78420500779,1503.34379984433,2148.84064315472,193676014.256469,11.2318110279928,13.6802589756049,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S3a",17245589,0.463627818482614,53097071420.885,3078.87839730408,1503.34379984433,2233.80546820848,193814316.627281,11.2384863530773,13.6802589756049,12.5481852613919,84.9648250537575,0.00295900627738099,28713.9725600581,27428.5057246669,62.9938915299717 -"S3b",17248093,0.463695135641656,55163743514.5954,3198.251743807,1503.34379984433,2289.26436882022,193983109.582457,11.2466409812643,13.6802589756049,12.5518021496191,140.4237256655,0.00657589450465501,21354.3154571739,20395.7175900449,188.379402281949 -"S3c",17249568,0.463734789319606,53820717605.7799,3120.11973898592,1503.34379984433,2253.09904935917,193896397.024298,11.240652347021,13.6802589756049,12.5489285096758,104.258406204442,0.00370225456133788,28160.7881027949,25373.5368288094,80.8627245770767 -"S3d",17250373,0.463756430818419,54140141633.3456,3138.49107108267,1503.34379984433,2261.6538622163,193895422.308672,11.2400712905554,13.6802589756049,12.5486062442593,112.813219061578,0.00337998914478099,33376.7992230897,29382.4638424138,56.1946408922086 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,933240063.269734,12.5454738885578,0,12.5454738885578,0,0,NA,NA,0 +"S1a",74380275,1,181401075128.178,2438.8330794445,0,2438.8330794445,934239601.55953,12.560313894504,0,12.560313894504,288.966086316825,0.014840005946251,19472.1004400827,19152.7317138316,453.034210995655 +"S1b",74383024,1,175747140583.673,2362.73185913594,0,2362.73185913594,933787724.01465,12.5537746894325,0,12.5537746894325,212.864866008269,0.00830080087472673,25643.8949952859,24838.024508073,202.175177728059 +"S1c",74393892,1,177409072797.107,2384.72632668697,0,2384.72632668697,933746980.213024,12.5513930661542,0,12.5513930661542,234.859333559296,0.00591917759642335,39677.6967295607,37796.7045192932,61.0995462618303 +"S2NoCD",44156404,0.593591118938596,117605933754.634,2663.39473102553,1399.82062664894,2149.86699312767,541859031.247822,12.2713577683505,12.9458413561387,12.5454738885578,0,0,NA,NA,0 +"S2a",44164773,0.593703622757395,127735308298.483,2892.24419422426,1399.82062664894,2285.87790540693,542449119.230119,12.2823934639066,12.9458413561387,12.5519499390097,136.010912279254,0.00647605045197786,21002.1390796476,20737.2033810468,187.791610319633 +"S3NoCD",34500334,0.46378531781744,99842281257.7915,2893.95115009007,1506.29023425363,2149.86699312767,387517175.854486,11.2322731673985,13.6812936153544,12.5454738885578,0,0,NA,NA,-1.16415321826935e-10 +"S3a",34507415,0.463880507151998,106095806862.256,3074.57996671892,1506.29023425363,2233.7892707109,387796822.974073,11.2380722512559,13.6812936153544,12.5479308498918,83.9222775832291,0.00245696133404039,34156.9386626129,31147.8193918049,38.925789118628 +"S3b",34499539,0.463774630694015,110363699543.429,3198.99055878484,1506.29023425363,2291.32170213873,388038736.167987,11.2476498937562,13.6812936153544,12.5526313971294,141.454709011058,0.00715750857160558,19763.1211469618,19837.7340923965,216.420719569083 +"S3c",34496334,0.463731546127251,107627143927.157,3119.95888975209,1506.29023425363,2254.59929480501,387776879.328762,11.2411040352509,13.6812936153544,12.5497007285294,104.732301677339,0.00422683997161855,24777.9197652555,25592.925116818,106.609696903499 +"S3d",34507664,0.463883854439712,108255487965.337,3137.14333040154,1506.29023425363,2262.81665451966,387911627.531503,11.2413180889759,13.6812936153544,12.5494283634394,112.949661391986,0.00395447488162048,28562.4930675249,26887.1518929379,84.7740826888476 diff --git a/reproduction/outputs/Sen2_50_Med_Adherenceceplane_5y.csv b/reproduction/outputs/Sen2_50_Med_Adherenceceplane_5y.csv index 9c231fc..33fc538 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherenceceplane_5y.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherenceceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466645458.453711,12.5452260864825,0,12.5452260864825,0,0,NA,NA,0 -"S1a",37197502,1,87609315425.5502,2355.24728046389,0,2355.24728046389,467053611.148306,12.5560477461176,0,12.5560477461176,206.406666193722,0.0108216596351252,19073.4760797469,20089.6428297252,334.67631556245 -"S1b",37190655,1,85474784067.1315,2298.28660095208,0,2298.28660095208,466807667.374783,12.5517463291459,0,12.5517463291459,149.44598668191,0.00652024266343787,22920.3105460975,25093.0398812956,176.566146490048 -"S1c",37195162,1,86086185363.3803,2314.4457702155,0,2314.4457702155,466843146.799544,12.5511792850786,0,12.5511792850786,165.60515594533,0.00595319859612253,27817.8450242182,30805.4976534331,132.054773860844 -"S2NoCD",22074342,0.593443287202261,58922537504.9946,2669.27718638203,1389.16908130145,2148.84064315472,270895360.188654,12.2719562915467,12.9441133485222,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S2a",22077777,0.593535633225147,62347138313.8362,2823.97717459671,1389.16908130145,2240.77881151202,271063504.04804,12.2776629208656,12.9441133485222,12.5485512719299,91.9381683572924,0.00332501681541331,27650.4371139141,27108.8202105676,74.3210751280421 -"S3NoCD",17254548,0.463868670889904,50064966232.8174,2901.55188260031,1497.58386473614,2148.84064315472,193797356.892219,11.2316681313367,13.6817359644516,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S3a",17251608,0.463789632372499,52066304895.3422,3018.05518044128,1497.58386473614,2202.76269727995,193847859.558584,11.2365096377441,13.6817359644516,12.5476653453204,53.9220541252316,0.00243909020591815,22107.4456346044,24063.4397718265,68.0408588855062 -"S3b",17246874,0.463662364229167,53626126689.0333,3109.32443114232,1497.58386473614,2244.88730628008,193956938.999034,11.2459184776925,13.6817359644516,12.5523390697101,96.0466631253616,0.00711281459564361,13503.3272460367,14580.1753413121,259.602469371515 -"S3c",17246125,0.463642228225923,52687996543.3235,3055.06289345134,1497.58386473614,2219.6969120248,193867413.988793,11.2412158666827,13.6817359644516,12.5502077882919,70.8562688700772,0.00498153317740346,14223.78740575,16078.2641419832,178.228792714886 -"S3d",17255729,0.463900420716114,52823751958.8562,3061.22980714731,1497.58386473614,2222.95987527172,193917113.914449,11.2378395554571,13.6817359644516,12.5480113921325,74.1192321170006,0.00278513701798921,26612.4185769907,25873.7564345888,65.146021497203 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,933240063.269734,12.5454738885578,0,12.5454738885578,0,0,NA,NA,0 +"S1a",74386318,1,175298229824.161,2356.5923752828,0,2356.5923752828,934033198.37721,12.5565187724066,0,12.5565187724066,206.725382155124,0.0110448838488768,18716.8452818222,19145.7366308898,345.518810288631 +"S1b",74385413,1,170952563916.074,2298.20010431446,0,2298.20010431446,933637486.50531,12.551351788627,0,12.551351788627,148.33311118679,0.00587790006926348,25235.7320537735,26468.9578303756,145.561892276281 +"S1c",74390720,1,171904343831.839,2310.83048842435,0,2310.83048842435,933570750.279375,12.5495592767401,0,12.5495592767401,160.963495296681,0.00408538818233062,39399.8044036186,42521.8072883671,43.3059138196986 +"S2NoCD",44157029,0.593599520765188,117807957834.59,2667.93216170838,1393.16700996411,2149.86699312767,541828917.159047,12.2705021019201,12.9471051097595,12.5454738885578,0,0,NA,NA,1.16415321826935e-10 +"S2a",44154576,0.59356654527618,124844786046.661,2827.44841772824,1393.16700996411,2244.50847012452,542208652.492346,12.2797839230151,12.9471051097595,12.551005578354,94.6414769968451,0.00553168979623919,17108.9631709263,17185.879192054,181.943012815085 +"S3NoCD",34491937,0.463672437596811,99999943602.2554,2899.22666860534,1502.02143805571,2149.86699312767,387401839.065729,11.2316637672662,13.6813050189755,12.5454738885578,0,0,NA,NA,1.16415321826935e-10 +"S3a",34494037,0.46370066773416,104115381915.72,3018.35885187112,1502.02143805571,2205.14810935221,387590904.424574,11.2364610852761,13.6813050189755,12.5476292544133,55.2811162245339,0.00215536585552911,25648.1358293407,24833.0802794382,52.4871765519492 +"S3b",34509196,0.463904448997054,107308147372.611,3109.55222986393,1502.02143805571,2247.7621242753,388040453.250984,11.2445521260763,13.6813050189755,12.5508845108531,97.8951311476294,0.00541062229536848,18093.1371297952,16319.0336611223,172.63598362077 +"S3c",34504471,0.463840931188019,105270593424.191,3050.92616618268,1502.02143805571,2220.46684947165,387852045.425155,11.2406315525068,13.6813050189755,12.5492207655628,70.5998563439753,0.00374687700500331,18842.3202175308,16916.049337496,116.743993906188 +"S3d",34501231,0.463797376118965,105602366017.679,3060.82893151492,1502.02143805571,2224.99226339667,387776869.087764,11.2395082102364,13.6813050189755,12.5488060660667,75.1252702689999,0.00333217750890924,22545.3986374188,20600.8589166803,91.4836051765596 diff --git a/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults.csv b/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults.csv index 78cba28..be4d1af 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,0.400733319767278,0.0756570523768302,0.12787617648766,0.0110773590734583,0.842396438441783,0.046107470726434,0.0491632764596596,0.0110600304517264,0.00193027101638251,0.464626221589564 -"S1b",1,1,1,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,0.405990262060088,0.0763712808406,0.128937839397539,0.0111722226350007,0.842428092026923,0.0461200603625631,0.0491383508538841,0.0110450824446697,0.0019243970545918,0.334053051708208 -"S1c",1,1,1,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,0.407947954891178,0.0766530888642384,0.129489210724663,0.0112076760636524,0.842538166986253,0.0460584214654526,0.0491005034611762,0.0110279779725777,0.00192817614834111,0.288617682950729 -"S2NoCD",0.593556763930821,0.582309685946903,0.705357761730891,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535928947491,0.582469204763036,0.706205579755609,0.0223350819017627,0.146861435551105,0.229046748962462,0.0868671748983432,0.40717154949026,0.0764348498798735,0.129245718868216,0.0111517123369551,0.842521478413868,0.0460676071299697,0.0490956905759404,0.0110472695587943,0.00192542928407099,0.310401264733618 -"S3NoCD",0.463572330217334,0.415367575216711,0.586199735331415,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463627818482614,0.415521682993537,0.587418330972747,0.020135761944108,0.139262558345173,0.180514922789748,0.0822286518533507,0.41091282114974,0.0771068690707244,0.130110991228192,0.0112307468065051,0.842479359257107,0.0461006199327869,0.0491419221040822,0.0110143369803305,0.00191704201835805,0.230684563840532 -"S3b",0.463695135641656,0.415568309564907,0.587233190193687,0.022688346451263,0.146674288242097,0.23269825950894,0.087000110491251,0.406420061933482,0.0764673667010533,0.129141145874287,0.0111893784669518,0.842504903342492,0.0460727197764389,0.0491258682896983,0.011035402357133,0.00191563803310912,0.31741923502635 -"S3c",0.463734789319606,0.415536541294178,0.58767782317134,0.0213351323942394,0.142951005888522,0.207202321894185,0.0845726197929377,0.408416061307295,0.0768438830632355,0.129544969634437,0.0111987434083334,0.842454283191634,0.0461336208713429,0.049131868036605,0.0110135739715596,0.00192049474425886,0.273951977879277 -"S3d",0.463756430818419,0.415604987692288,0.587558132403041,0.0207663794232776,0.141381171887563,0.195210605479162,0.0835996238319034,0.409497721665754,0.0769666360150598,0.129714362011153,0.0112324729853736,0.842472623948323,0.0461088404884722,0.0491357216371956,0.0110219486609554,0.00191644348636688,0.254304413340487 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,0.400846084529803,0.0756315299990488,0.127733286815624,0.011087348090606,0.842364170321789,0.046129034765383,0.0491766451495284,0.011049622312511,0.00193589729339196,0.464833027470088 +"S1b",1,1,1,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,0.405907939424458,0.0764086574377509,0.129012461230401,0.0111605841676993,0.842479484739466,0.0460932357315975,0.0491198733047791,0.0110443784905514,0.00192158664025428,0.334294602837872 +"S1c",1,1,1,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,0.407967793915124,0.0766466687883462,0.129330321903309,0.0111360755262005,0.842511866298224,0.0461015049376835,0.0491018031400455,0.0110240858181335,0.00191735547661239,0.288407573923277 +"S2NoCD",0.593591118938596,0.582365621911992,0.705116455867408,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.593703622757395,0.582561633495118,0.706249983323194,0.0223572293275455,0.146520275764833,0.228783458335563,0.0867962070990575,0.406907175011621,0.0764857628938958,0.129161959754734,0.0111849702484567,0.842453436358219,0.0460995130135702,0.049162136254093,0.0110232564059888,0.00191909420686546,0.310203001792548 +"S3NoCD",0.46378531781744,0.415568056211066,0.586617239472126,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.463880507151998,0.415699320053362,0.586708781881545,0.0201156015599614,0.139591817454275,0.180822991967125,0.0824771154683174,0.410893918376555,0.0771596359153628,0.13002154727965,0.0112567726274374,0.842566021780609,0.0460728067506646,0.0490891975121309,0.0110179222026286,0.00191286787636638,0.231194614752874 +"S3b",0.463774630694015,0.415673744808273,0.587660544823951,0.022703218559012,0.147101677876022,0.233250693892965,0.0873282101842993,0.406897958993362,0.0765657243606348,0.12916424164248,0.0111938516834175,0.84245733212396,0.0460718832826625,0.0491420777172941,0.0110558113255998,0.00192827941971036,0.318156004167639 +"S3c",0.463731546127251,0.415538305063213,0.587311603486886,0.0213261904240776,0.143268049986543,0.207485881195491,0.0848645010202161,0.409017522509301,0.0768424095578439,0.12956240035588,0.0112182155362607,0.842485614704402,0.0460621493958521,0.0491521297235465,0.0110349049383035,0.00192076633511325,0.274243522611208 +"S3d",0.463883854439712,0.415752092299157,0.587221087548919,0.0207546147301295,0.141567271736428,0.195481611880112,0.0837050652172602,0.40984416843231,0.0769796311184294,0.1297896347637,0.0112424293950455,0.842510845247546,0.0460587342353947,0.0491389891816906,0.0110270863763496,0.00192123076545521,0.254532916078862 diff --git a/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults_5y.csv b/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults_5y.csv index fc6208a..2a670bd 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults_5y.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherenceclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,0.403047226128249,0.0760263148853383,0.12840956363145,0.0111267149068236,0.842461254812893,0.0461118957155039,0.049118855485952,0.0110334546540076,0.00192729365384067,0.399988053390932 -"S1b",1,1,1,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,0.408631980264935,0.0767122278432579,0.129370859426918,0.0112158820542419,0.8424572166305,0.0461045345921089,0.0491178381114376,0.0110465138362427,0.00192862473289225,0.294526778968184 -"S1c",1,1,1,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,0.409231958715491,0.0769956856216946,0.129978355787239,0.0112124528453459,0.842487284544981,0.0461078639931604,0.0491352633754891,0.0110153793798817,0.00191157483979592,0.26029455677229 -"S2NoCD",0.593443287202261,0.582273174807522,0.705545677347615,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535633225147,0.582295847461883,0.706034831690326,0.0214260856128922,0.143399662052018,0.208913322432459,0.0847853184386878,0.407655221861622,0.0767470760900907,0.129218216541159,0.011199194631369,0.842544394644732,0.046094763613817,0.0491127745862289,0.0109897656237673,0.00191086601779681,0.277612135628334 -"S3NoCD",0.463868670889904,0.415635368247289,0.587073562742789,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463789632372499,0.415622940758265,0.586809647097927,0.0197696669249095,0.138028597361208,0.171429592848262,0.081236444450917,0.411287856148879,0.07722846001244,0.130038331526943,0.0112026643175846,0.842626066479021,0.0461014349785822,0.0490229859734682,0.0109954420436182,0.00190926922852537,0.216839145396673 -"S3b",0.463662364229167,0.415627753354033,0.587309552953142,0.0217273072426316,0.144075656740584,0.212315561616708,0.085323826327292,0.407654369789789,0.0766217806454282,0.129340579136661,0.0111730977587919,0.84257351681126,0.0461000010925949,0.0490636336910152,0.0110096977534996,0.00191076692651309,0.284092335789576 -"S3c",0.463642228225923,0.415569605134916,0.587621281450251,0.0206710534473348,0.140931536559447,0.191763032350927,0.08324285525963,0.409917216243935,0.07702129939584,0.12970969386912,0.0111986612734943,0.842538118936641,0.0460823834781866,0.0491061374122304,0.0110204077894173,0.00191447077751689,0.249320504213185 -"S3d",0.463900420716114,0.415712328288473,0.587409792818855,0.0202416660684579,0.139590000283801,0.18228853527996,0.0822922365025336,0.410444613492492,0.077025066408215,0.129808877075041,0.0112098048644388,0.842570046688464,0.0461323938488098,0.0490485515602565,0.0110024025072699,0.00190357830414835,0.234231338952332 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,0.403687247969445,0.076043339045226,0.128491882068958,0.0111234434267872,0.842404538075766,0.0461249975109299,0.0491350481006971,0.0110626268806794,0.00192774403765099,0.400376813672669 +"S1b",1,1,1,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,0.408261469221123,0.0767148930126932,0.12942550981064,0.0111918986051741,0.842444102006296,0.0461405534347918,0.049119839074542,0.0110326731874807,0.0019206407489528,0.294383825212184 +"S1c",1,1,1,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,0.409414400075708,0.0768280371530212,0.129676147777572,0.0111990850471672,0.842566279080345,0.0460770376386533,0.0490825292231934,0.0110175512447196,0.00191369725957158,0.260088914224771 +"S2NoCD",0.593599520765188,0.582336120728919,0.705468838282451,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.59356654527618,0.582414633463478,0.70594630719989,0.0213965559374253,0.143850474561616,0.209480412096954,0.0850850980302915,0.408667539118558,0.0767385183547775,0.129416522072223,0.0112172729297281,0.842512558981358,0.0461063547945422,0.0490973671326712,0.0110198437844154,0.00191734574481944,0.277927102442024 +"S3NoCD",0.463672437596811,0.415434005363706,0.586089346363954,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.46370066773416,0.415527713942897,0.586531096227929,0.0197899392090461,0.138303277630978,0.171711091371148,0.0814794148216474,0.412123358096292,0.0772548393515772,0.130128312756924,0.0112117859678794,0.842519910814925,0.0460735235689768,0.0491516810272371,0.0110056311963728,0.00190514377766393,0.217315925410359 +"S3b",0.463904448997054,0.415785735654782,0.587675158368244,0.0217415888048102,0.144179021361847,0.212418250542373,0.0853294076058373,0.409418571728946,0.0768062462692041,0.129433160211189,0.0111817841277405,0.842414303912108,0.0460965101654088,0.0491882510131361,0.0110409375550577,0.00191758449244497,0.28441849116625 +"S3c",0.463840931188019,0.415695058927611,0.586925015622923,0.0206753702957292,0.141063374890625,0.191706805465128,0.0833410596328628,0.410579318361524,0.076984479764633,0.129710841719411,0.0112076528740334,0.842489353520781,0.0460832909926345,0.0491418310503537,0.0110238974057143,0.0019169509018325,0.24963076915198 +"S3d",0.463797376118965,0.41566768511288,0.586881023447397,0.02025846993191,0.139712240331005,0.182490438501157,0.0824624734254074,0.411214425863804,0.0771279852307872,0.129855466070449,0.0112227977270353,0.842491682442217,0.0460936959542376,0.0491366016280874,0.011022918093246,0.00191137314896782,0.234585140125143 diff --git a/reproduction/outputs/Sen2_50_Med_Adherences1.csv b/reproduction/outputs/Sen2_50_Med_Adherences1.csv index 69f1321..4385827 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherences1.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherences1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466614758.380329,12.5445924752228,625082.515223931,0,0,NA,0 -"S1NoCD2",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466676158.527093,12.545859678375,625142.41128036,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466645458.453711,12.5452260864825,625112.463252145,0,0,NA,0 -"S1a",37195779,626218800.231142,71281372.3281143,186100281,33119194.6945306,13388772,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,14905588,2814123,4756454,412031,0.209109161526637,0.0394790799908614,0.0667278679499271,0.0057803460643741,527524487,28873365,30786968,6925999,1208772,90753454325.5885,2439.88583558335,467242137.557907,12.5616978624888,625645.007288858,292.777298375314,0.0171053872660547,17116.0871029401,562.492064927472 -"S1b",37200476,626144171.819881,71252444.7802286,188422793,23802096.6205059,13372758,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,15103031,2841048,4796549,415612,0.211965091816623,0.0398729897446037,0.067317676113353,0.00583295073287542,527481440,28877807,30767692,6915814,1204950,87878153021.8125,2362.2857143498,466988044.397164,12.5532814256776,625301.785569528,215.177177141765,0.00868895045478446,24764.4612846515,219.270345597528 -"S1c",37192813,625960445.075725,71159107.171146,189176712,20537776.6325788,13372239,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,15172732,2850944,4816068,416845,0.213222630288317,0.0400643587776213,0.0676802758137028,0.0058579290349644,527395566,28830750,30734973,6903078,1206962,88797560537.4716,2387.49245821959,466783360.164217,12.5503645062883,625130.732856194,240.383921011561,0.00577203106549895,41646.3318169583,48.2176322634332 +"S1NoCD",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,933216569.304974,12.5451309094502,625108.508032418,0,0,NA,0 +"S1NoCD2",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,933263557.234494,12.5458168691499,625139.146903416,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,933240063.269734,12.5454738885578,625123.827467917,0,0,NA,0 +"S1a",74380275,1252107231.24309,142568770.421589,372100831,66270673.1777553,26745802,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,29815042,5625494,9500837,824680,0.209127440124749,0.0394581084157834,0.0666403797402835,0.00578443650430136,1054730269,57758498,61574433,13835312,2423951,181401075128.178,2438.8330794445,934239601.55953,12.560313894504,625576.861645756,290.795639349996,0.0151829850537712,19152.7317138316,468.35361333855 +"S1b",74383024,1252030977.73496,142410669.767258,376764647,47607118.2897207,26748888,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,30192660,5683507,9596337,830158,0.212011221134933,0.0399092779304288,0.0673849579928479,0.00582932445551117,1054810413,57710159,61499603,13827904,2405886,175747140583.673,2362.73185913594,933787724.01465,12.5537746894325,625326.002612489,214.694419041441,0.00864377998224697,24838.024508073,217.494580070954 +"S1c",74393892,1252166866.96087,142379317.946113,378416895,41063273.6656893,26758496,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,30350312,5702044,9621386,828456,0.213165173410135,0.0400482603952217,0.0675757275620708,0.00581865408509366,1054965444,57726777,61483651,13803995,2400849,177409072797.107,2384.72632668697,933746980.213024,12.5513930661542,625184.926981023,236.688886592467,0.00626215670394359,37796.7045192932,76.4189486047253 diff --git a/reproduction/outputs/Sen2_50_Med_Adherences1_5y.csv b/reproduction/outputs/Sen2_50_Med_Adherences1_5y.csv index b3c31be..31ba743 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherences1_5y.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherences1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466614758.380329,12.5445924752228,625082.515223931,0,0,NA,0 -"S1NoCD",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466676158.527093,12.545859678375,625142.41128036,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466645458.453711,12.5452260864825,625112.463252145,0,0,NA,0 -"S1a",37197502,626089852.781592,71222083.952196,122776626,28487982.7184844,16327137,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,14992350,2827989,4776515,413886,0.210501422705671,0.0397066309081624,0.0670650833975313,0.00581120316948039,527456443,28870190,30752817,6907934,1206659,87609315425.5502,2355.24728046389,467053611.148306,12.5560477461176,625447.140025417,204.674642075062,0.0101880677426589,20089.6428297252,304.72874505783 -"S1b",37190655,625992698.014129,71214502.2789584,123717512,20974577.9720441,16327973,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,15197291,2852978,4811387,417126,0.213401631882082,0.0400617558039574,0.0675618988552786,0.00585731819575248,527372066,28861102,30747408,6915037,1207305,85474784067.1315,2298.28660095208,466807667.374783,12.5517463291459,625289.029856345,147.71396256325,0.00588665077097161,25093.0398812956,146.618575985427 -"S1c",37195162,626110981.941873,71210037.1648892,124047387,18535585.0615731,16324587,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,15221449,2863867,4834566,417049,0.213754262826099,0.0402171816505112,0.0678916370848874,0.00585660416149354,527490541,28868640,30764128,6896850,1196858,86086185363.3803,2314.4457702155,466843146.799544,12.5511792850786,625244.518483716,163.87313182667,0.00531960670365628,30805.4976534331,102.107203356223 +"S1NoCD2",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,933216569.304974,12.5451309094502,625108.508032418,0,0,NA,0 +"S1NoCD",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,933263557.234494,12.5458168691499,625139.146903416,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,933240063.269734,12.5454738885578,625123.827467917,0,0,NA,0 +"S1a",74386318,1252092577.05249,142511621.315835,245523949,57058348.8537602,32655914,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,30028808,5656584,9558038,827432,0.210711293035183,0.0396920893031161,0.0670684812350664,0.00580606684816418,1054768469,57752767,61521629,13851433,2413714,175298229824.161,2356.5923752828,934033198.37721,12.5565187724066,625469.346245049,204.895821202494,0.0107019032567237,19145.7366308898,330.199341633706 +"S1b",74385413,1252007175.89227,142455061.307373,247448362,41936465.8685008,32651747,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,30368698,5706469,9627370,832514,0.213180898743035,0.0400580291611207,0.0675818037747859,0.0058440464828673,1054746061,57768304,61498391,13812986,2404656,170952563916.074,2298.20010431446,933637486.50531,12.551351788627,625269.389327037,146.503550234159,0.00553491947711038,26468.9578303756,130.242423621356 +"S1c",74390720,1252048090.68724,142295860.364143,248074520,37009575.8207896,32668233,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,30456632,5715293,9646702,833108,0.214037372008291,0.0401648578207,0.0677932722379522,0.00585475921694439,1054933501,57690667,61453687,13794504,2396041,171904343831.839,2310.83048842435,933570750.279375,12.5495592767401,625167.13334858,159.133934344051,0.00374240759017752,42521.8072883671,27.9864451647736 diff --git a/reproduction/outputs/Sen2_50_Med_Adherences2.csv b/reproduction/outputs/Sen2_50_Med_Adherences2.csv index d5798b5..c2df414 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherences2.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherences2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078563,364522748.573687,50166624.1671238,110968095,9653605.82348446,7738507,0.0172779795723912,0.141222462720366,0.158929640922804,0.0870932535738703,11438971,2125413,3543389,304919,0.228019548652357,0.0423670724368348,0.0706323987078669,0.00607812475051542,298790021,18633807,22502661,5543543,1025792,58731887920.9201,2660.13181749736,270917817.912949,12.270627300923,610871.233228654,0,0,NA,0 -"S2a",22077788,364622606.499305,50226922.8843361,108797477,18511083.7047635,7734136,0.0229898067769556,0.157327004308664,0.269003214018226,0.0973502415391329,11192847,2087413,3500787,300763,0.22284556483333,0.041559643317329,0.0696994121670902,0.00598808333714978,298828425,18622586,22524521,5579724,1036307,63840415722.8595,2891.61286098315,271190365.071176,12.2834028966659,611278.531972313,231.481043485787,0.0127755957429017,18119.0018958139,407.298743659281 +"S2NoCD",44156404,729084497.054691,100330759.79117,221928932,19330951.6588092,15481473,0.0172596709453046,0.141645486548806,0.159259990701265,0.08725337635747,22917076,4253860,7098458,609501,0.228415254182267,0.0423983632622146,0.070750565577046,0.00607491661847899,597619551,37246010,44990133,11123560,2050468,117605933754.634,2663.39473102553,541859031.247822,12.2713577683505,610904.493686498,0,0,NA,0 +"S2a",44164773,729329891.015329,100492048.993736,217625447,37010683.2532179,15485858,0.0230145995823502,0.157180410449991,0.268827891528291,0.0973046709934024,22383331,4181008,7006346,603148,0.222737333193348,0.0416053612386849,0.0697204014661571,0.00600194747783078,597700094,37284225,45068617,11147317,2064302,127735308298.483,2892.24419422426,542449119.230119,12.2823934639066,611227.429001106,228.84946319874,0.0110356955561279,20737.2033810468,322.93531460769 diff --git a/reproduction/outputs/Sen2_50_Med_Adherences2_5y.csv b/reproduction/outputs/Sen2_50_Med_Adherences2_5y.csv index 8aada95..a31217f 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherences2_5y.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherences2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22074342,364499892.795735,50179989.1467565,72492409,9769650.24862608,9434235,0.0208917555301636,0.141988942022567,0.159733364688847,0.0874666663868567,11472370,2126666,3551252,304704,0.228624401779918,0.0423807584688858,0.070770282345299,0.00607222132130921,298757005,18626945,22501053,5562438,1027303,58922537504.9946,2669.27718638203,270895360.188654,12.2719562915467,610928.537390955,0,0,NA,0 -"S2a",22077777,364514085.756087,50214778.8994209,71673455,16290550.2537317,9435494,0.0250429167756047,0.153202361136407,0.241328632393267,0.094789501013715,11245330,2100490,3507989,302346,0.223944628383691,0.0418301154767053,0.0698596922437202,0.00602105608401846,298734836,18629376,22530917,5562183,1028646,62347138313.8362,2823.97717459671,271063504.04804,12.2776629208656,611059.168868685,154.699988214681,0.00570662931890986,27108.8202105676,130.631477730698 +"S2NoCD",44157029,729047563.461063,100380900.154714,145000421,19524492.074223,18863743,0.0209029627109113,0.141781753914197,0.159519185673724,0.0873704363140082,22925265,4254784,7099566,609563,0.228382739790797,0.0423863901742486,0.0707262635527043,0.00607249983871931,597538799,37245010,45040554,11117169,2054803,117807957834.59,2667.93216170838,541828917.159047,12.2705021019201,610857.172934297,0,0,NA,0 +"S2a",44154576,729145856.381239,100448839.030434,143361789,32595478.4145126,18878233,0.0250078581664384,0.153560443203067,0.241814960491553,0.0950258179639202,22519648,4200194,7025459,605531,0.224190226759883,0.0418142612751096,0.0699406689794734,0.00602825284836329,597564735,37286040,45033303,11135908,2066352,124844786046.661,2827.44841772824,542208652.492346,12.2797839230151,611161.747733024,159.516256019854,0.00928182109493747,17185.879192054,304.574798727059 diff --git a/reproduction/outputs/Sen2_50_Med_Adherences3.csv b/reproduction/outputs/Sen2_50_Med_Adherences3.csv index ad3398b..6eeb1f2 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherences3.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherences3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17243525,260017880.24558,41691838.3900313,80059027,7819384.14256,5815322,0.0183575174217772,0.137156256672018,0.154366597029931,0.0863650846874626,9754415,1816466,3038101,261338,0.233964616977224,0.043568863119126,0.0728704014339272,0.00626832517086814,207433146,15294590,18682841,4808648,895345,49933527333.6569,2895.78420500779,193676014.256469,11.2318110279928,558694.76719463,0,0,NA,0 -"S3a",17245589,260114350.889536,41778507.6419587,79305268,11012874.3912697,5816924,0.0210701415875502,0.143601112787989,0.204102307078173,0.090802566674972,9648241,1803612,3027939,260144,0.230937904309204,0.0431708096291264,0.0724759971310943,0.00622674228168777,207442211,15303706,18733677,4824249,900624,53097071420.885,3078.87839730408,193814316.627281,11.2384863530773,558845.439256563,183.094192296297,0.00667532508457569,27428.5057246669,150.672061932506 -"S3b",17248093,260143538.873804,41765340.0149969,77789956,17179218.0534133,5809490,0.0272123567386269,0.156225870536493,0.292983388954392,0.0989344402695251,9481831,1779958,2992091,258625,0.227026309293671,0.0426180655864614,0.0716405277420372,0.00619233555639998,207483725,15287322,18724587,4837601,899769,55163743514.5954,3198.251743807,193983109.582457,11.2466409812643,559133.797319406,302.467538799216,0.0148299532715068,20395.7175900449,439.030124776182 -"S3c",17249568,260123652.106259,41796963.3084409,78552778,14093542.3037528,5811921,0.0239564020668036,0.149872778444183,0.249488678363603,0.0947819160826065,9556493,1794042,3007246,258985,0.228640844778072,0.0429227833314315,0.0719489111639047,0.00619626354404789,207434647,15324709,18727689,4823824,902793,53820717605.7799,3120.11973898592,193896397.024298,11.240652347021,558912.497612064,224.335533978136,0.00884131902823349,25373.5368288094,217.730417433544 -"S3d",17250373,260166499.185349,41788450.6328664,78909896,12694598.7095123,5812281,0.0225871693478081,0.14720440466007,0.229100157335109,0.0931309605323503,9596955,1798651,3013620,260246,0.229655678893537,0.0430418207126676,0.0721160979734865,0.00622770157923294,207483596,15310784,18731510,4829309,900292,54140141633.3456,3138.49107108267,193895422.308672,11.2400712905554,558865.073456686,242.706866074884,0.00826026256261514,29382.4638424138,170.306262055878 +"S3NoCD",34500334,520264617.028559,83469550.1049324,160191877,15617539.1621454,11630123,0.018371612334161,0.136660912007116,0.153889981724535,0.0860423303941354,19525292,3631989,6073558,522424,0.23392113621619,0.0435127420171081,0.0727637562723739,0.00625885726403513,415002016,30608834,37422882,9624470,1788687,99842281257.7915,2893.95115009007,387517175.854486,11.2322731673985,558719.707219835,0,0,NA,0 +"S3a",34507415,520428950.960441,83482575.6405212,158676520,22030097.8695766,11639538,0.0210425232718254,0.143591703407669,0.204088019848658,0.0908272943093332,19287934,3609226,6045313,521405,0.231041434119792,0.043233285177274,0.072414069087079,0.00624567457340066,415152628,30610103,37407716,9641236,1794702,106095806862.256,3074.57996671892,387796822.974073,11.2380722512559,558829.032596078,180.628816628857,0.00579908385742023,31147.8193918049,109.325376242166 +"S3b",34499539,520396932.389974,83618001.6376853,155590263,34428826.1327912,11625591,0.0272677362023387,0.156355277894248,0.293211112522871,0.0990494988470827,18988453,3564625,5980823,516662,0.227085706762959,0.0426298755074946,0.0715255433383203,0.00617883697147755,414988556,30607762,37472866,9688489,1813970,110363699543.429,3198.99055878484,388038736.167987,11.2476498937562,559183.504129024,305.03940869477,0.0153767263576583,19837.7340923965,463.796909188153 +"S3c",34496334,520227370.495019,83568350.903854,157099275,28171360.7955484,11622564,0.0239564406652199,0.14984119401007,0.249428440470547,0.0948714951513754,19145218,3585036,6010150,518449,0.229096515522087,0.0428994465156386,0.0719189733313599,0.00620389171728995,414875686,30589301,37479876,9661353,1804425,107627143927.157,3119.95888975209,387776879.328762,11.2411040352509,558935.242872791,226.007739662019,0.00883086785236209,25592.925116818,215.53565295611 +"S3d",34507664,520495018.435642,83555471.4245087,157877292,25364365.9811382,11630839,0.0225793272116635,0.14694733242596,0.229001602594022,0.0929007877476101,19209915,3595849,6028084,520340,0.229906129095997,0.0430354701935804,0.0721446949820192,0.00622747967462694,415141325,30594930,37472224,9653084,1805226,108255487965.337,3137.14333040154,387911627.531503,11.2413180889759,558928.761118394,243.192180311468,0.00904492157740755,26887.1518929379,209.053898558952 diff --git a/reproduction/outputs/Sen2_50_Med_Adherences3_5y.csv b/reproduction/outputs/Sen2_50_Med_Adherences3_5y.csv index cd986a9..289e0e9 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherences3_5y.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherences3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17254548,260185517.250271,41753986.9530892,52456874,7922835.39457538,7061036,0.0221592886073816,0.13726133321656,0.154573171523665,0.0864947424330528,9767617,1818208,3040076,262205,0.233932558607492,0.043545733777298,0.0728092386342779,0.00627975959025394,207533583,15301679,18724752,4815426,897482,50064966232.8174,2901.55188260031,193797356.892219,11.2316681313367,558681.854684234,0,0,NA,0 -"S3a",17251608,260177737.708618,41735216.681199,52193377,10112285.5219638,7056308,0.0239901655742498,0.141620447019917,0.188896901320193,0.0892874240346538,9673981,1809610,3026757,259927,0.23179419610772,0.0433593052558704,0.0725228533763311,0.00622800168944835,207543323,15307443,18697708,4818609,897810,52066304895.3422,3018.05518044128,193847859.558584,11.2365096377441,558807.426706766,116.503297840971,0.00484150640746606,24063.4397718265,125.572022532346 -"S3b",17246874,260180750.367826,41770771.1055183,51592135,14901907.2426103,7060341,0.0287001627876402,0.151909252445312,0.258476623670136,0.0962303406481393,9537491,1786791,3000373,258790,0.228329301748035,0.0427761076156898,0.0718294855611038,0.00619548055137079,207513062,15306657,18723252,4827550,898750,53626126689.0333,3109.32443114232,193956938.999034,11.2459184776925,559186.599453482,207.772548542013,0.0142503463558015,14580.1753413121,504.744769248064 -"S3c",17246125,260144349.893699,41792941.9345714,51894923,12432862.6252413,7060467,0.0261601311174318,0.146548593395628,0.223441477763239,0.0926749735395,9621451,1801612,3014035,259735,0.23021712649621,0.0431080444832167,0.0721182778833468,0.00621480537088358,207459068,15294280,18748666,4834049,901039,52687996543.3235,3055.06289345134,193867413.988793,11.2412158666827,559005.730440684,153.511010851031,0.00954773534601827,16078.2641419832,323.875756449881 -"S3d",17255729,260233693.824386,41777900.3893267,52047317,11356969.6042882,7062160,0.0251240111093077,0.14426968081771,0.207339855216131,0.0910648854849654,9643777,1802264,3018596,260225,0.23083441030138,0.0431391712653046,0.0722534156065723,0.00622877161310102,207557193,15328896,18715546,4823282,894293,52823751958.8562,3061.22980714731,193917113.914449,11.2378395554571,558830.747965709,159.677924547001,0.00617142412044736,25873.7564345888,148.893281475292 +"S3NoCD",34491937,520096793.944658,83394436.3897572,104866546,15798843.6062051,14116443,0.0221440059305719,0.13704346682043,0.154368086406791,0.0863943143443837,19479590,3630576,6075819,523166,0.233583807784959,0.0435349905481935,0.0728564070102194,0.00627339211880875,414917152,30599570,37365292,9614469,1790750,99999943602.2554,2899.22666860534,387401839.065729,11.2316637672662,558683.961694705,0,0,NA,0 +"S3a",34494037,520214111.090036,83457292.8145667,104351592,20245608.2892442,14129448,0.0240307345372679,0.14177714164029,0.189041590205167,0.0894698764862355,19332282,3614629,6055063,518761,0.231642812126129,0.0433111221092604,0.0725528326620145,0.00621588578427331,414968911,30599997,37426814,9615582,1787056,104115381915.72,3018.35885187112,387590904.424574,11.2364610852761,558804.695411934,119.132183265779,0.00479731800989747,24833.0802794382,120.733717229101 +"S3b",34509196,520537137.764278,83620080.9934994,103218767,29823148.4264926,14132996,0.0287201148667908,0.151759070463881,0.258228121857447,0.0959834805484866,19135380,3582069,6004729,516649,0.228837137834004,0.0428374256212269,0.0718096530002979,0.00617852785911753,415119150,30640730,37483240,9661621,1802895,107308147372.611,3109.55222986393,388040453.250984,11.2445521260763,559118.054073951,210.325561258588,0.0128883588100965,16319.0336611223,434.092379246256 +"S3c",34504471,520423616.303641,83513343.4596301,103824096,24853846.8628113,14121585,0.0261578150769642,0.14647414308412,0.223082059564315,0.0926287674905986,19220385,3595075,6024956,518536,0.23014747349076,0.0430479112806427,0.0721436329861758,0.00620901976281979,415113845,30619979,37421385,9639642,1802009,105270593424.191,3050.92616618268,387852045.425155,11.2406315525068,558980.651459156,151.699497577334,0.00896778524055719,16916.049337496,296.689764450537 +"S3d",34501231,520389346.039061,83507083.8292405,104079260,22711873.9482136,14135933,0.0251554674459531,0.144172895875718,0.20738377463961,0.0911334097630808,19266710,3605577,6035420,519637,0.230719468535119,0.0431768999067536,0.0722743475552509,0.00622266969665208,415086795,30631737,37413709,9638221,1794998,105602366017.679,3060.82893151492,387776869.087764,11.2395082102364,558914.581580307,161.602262909575,0.00784444297022624,20600.8589166803,230.619885601802 diff --git a/reproduction/outputs/Sen2_50_Med_Adherencesall.csv b/reproduction/outputs/Sen2_50_Med_Adherencesall.csv index 33ac403..9a8f40b 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherencesall.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherencesall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37195779,90753454325.5885,2439.88583558335,467242137.557907,12.5616978624888,17116.0871029401,562.492064927472 -"S3b",17248093,55163743514.5954,3198.251743807,193983109.582457,11.2466409812643,20395.7175900449,439.030124776182 -"S2a",22077788,63840415722.8595,2891.61286098315,271190365.071176,12.2834028966659,18119.0018958139,407.298743659281 -"S1b",37200476,87878153021.8125,2362.2857143498,466988044.397164,12.5532814256776,24764.4612846515,219.270345597528 -"S3c",17249568,53820717605.7799,3120.11973898592,193896397.024298,11.240652347021,25373.5368288094,217.730417433544 -"S3d",17250373,54140141633.3456,3138.49107108267,193895422.308672,11.2400712905554,29382.4638424138,170.306262055878 -"S3a",17245589,53097071420.885,3078.87839730408,193814316.627281,11.2384863530773,27428.5057246669,150.672061932506 -"S1c",37192813,88797560537.4716,2387.49245821959,466783360.164217,12.5503645062883,41646.3318169583,48.2176322634332 -"S1NoCD",37196486,79864892644.739,2147.10853720803,466614758.380329,12.5445924752228,NA,0 -"S2NoCD",22078563,58731887920.9201,2660.13181749736,270917817.912949,12.270627300923,NA,0 -"S3NoCD",17243525,49933527333.6569,2895.78420500779,193676014.256469,11.2318110279928,NA,0 +"S1a",74380275,181401075128.178,2438.8330794445,934239601.55953,12.560313894504,19152.7317138316,468.35361333855 +"S3b",34499539,110363699543.429,3198.99055878484,388038736.167987,11.2476498937562,19837.7340923965,463.796909188153 +"S2a",44164773,127735308298.483,2892.24419422426,542449119.230119,12.2823934639066,20737.2033810468,322.93531460769 +"S1b",74383024,175747140583.673,2362.73185913594,933787724.01465,12.5537746894325,24838.024508073,217.494580070954 +"S3c",34496334,107627143927.157,3119.95888975209,387776879.328762,11.2411040352509,25592.925116818,215.53565295611 +"S3d",34507664,108255487965.337,3137.14333040154,387911627.531503,11.2413180889759,26887.1518929379,209.053898558952 +"S3a",34507415,106095806862.256,3074.57996671892,387796822.974073,11.2380722512559,31147.8193918049,109.325376242166 +"S1c",74393892,177409072797.107,2384.72632668697,933746980.213024,12.5513930661542,37796.7045192932,76.4189486047253 +"S1NoCD",74388747,159789813677.717,2148.0374400945,933216569.304974,12.5451309094502,NA,0 +"S2NoCD",44156404,117605933754.634,2663.39473102553,541859031.247822,12.2713577683505,NA,0 +"S3NoCD",34500334,99842281257.7915,2893.95115009007,387517175.854486,11.2322731673985,NA,0 diff --git a/reproduction/outputs/Sen2_50_Med_Adherencesall_5y.csv b/reproduction/outputs/Sen2_50_Med_Adherencesall_5y.csv index 2347571..3f6d9c0 100644 --- a/reproduction/outputs/Sen2_50_Med_Adherencesall_5y.csv +++ b/reproduction/outputs/Sen2_50_Med_Adherencesall_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S3b",17246874,53626126689.0333,3109.32443114232,193956938.999034,11.2459184776925,14580.1753413121,504.744769248064 -"S3c",17246125,52687996543.3235,3055.06289345134,193867413.988793,11.2412158666827,16078.2641419832,323.875756449881 -"S1a",37197502,87609315425.5502,2355.24728046389,467053611.148306,12.5560477461176,20089.6428297252,304.72874505783 -"S3d",17255729,52823751958.8562,3061.22980714731,193917113.914449,11.2378395554571,25873.7564345888,148.893281475292 -"S1b",37190655,85474784067.1315,2298.28660095208,466807667.374783,12.5517463291459,25093.0398812956,146.618575985427 -"S2a",22077777,62347138313.8362,2823.97717459671,271063504.04804,12.2776629208656,27108.8202105676,130.631477730698 -"S3a",17251608,52066304895.3422,3018.05518044128,193847859.558584,11.2365096377441,24063.4397718265,125.572022532346 -"S1c",37195162,86086185363.3803,2314.4457702155,466843146.799544,12.5511792850786,30805.4976534331,102.107203356223 -"S1NoCD",37197623,79996190236.903,2150.57263838883,466676158.527093,12.545859678375,NA,0 -"S2NoCD",22074342,58922537504.9946,2669.27718638203,270895360.188654,12.2719562915467,NA,0 -"S3NoCD",17254548,50064966232.8174,2901.55188260031,193797356.892219,11.2316681313367,NA,0 +"S3b",34509196,107308147372.611,3109.55222986393,388040453.250984,11.2445521260763,16319.0336611223,434.092379246256 +"S1a",74386318,175298229824.161,2356.5923752828,934033198.37721,12.5565187724066,19145.7366308898,330.199341633706 +"S2a",44154576,124844786046.661,2827.44841772824,542208652.492346,12.2797839230151,17185.879192054,304.574798727059 +"S3c",34504471,105270593424.191,3050.92616618268,387852045.425155,11.2406315525068,16916.049337496,296.689764450537 +"S3d",34501231,105602366017.679,3060.82893151492,387776869.087764,11.2395082102364,20600.8589166803,230.619885601802 +"S1b",74385413,170952563916.074,2298.20010431446,933637486.50531,12.551351788627,26468.9578303756,130.242423621356 +"S3a",34494037,104115381915.72,3018.35885187112,387590904.424574,11.2364610852761,24833.0802794382,120.733717229101 +"S1c",74390720,171904343831.839,2310.83048842435,933570750.279375,12.5495592767401,42521.8072883671,27.9864451647736 +"S1NoCD",74388425,160061317735.961,2151.6965540803,933263557.234494,12.5458168691499,NA,0 +"S2NoCD",44157029,117807957834.59,2667.93216170838,541828917.159047,12.2705021019201,NA,0 +"S3NoCD",34491937,99999943602.2554,2899.22666860534,387401839.065729,11.2316637672662,NA,0 diff --git a/reproduction/outputs/Sen3_30_Med_Adherence_CEplot-1.png b/reproduction/outputs/Sen3_30_Med_Adherence_CEplot-1.png index 3f813ce..fb99f3c 100644 Binary files a/reproduction/outputs/Sen3_30_Med_Adherence_CEplot-1.png and b/reproduction/outputs/Sen3_30_Med_Adherence_CEplot-1.png differ diff --git a/reproduction/outputs/Sen3_30_Med_Adherence_CEplot_5y-1.png b/reproduction/outputs/Sen3_30_Med_Adherence_CEplot_5y-1.png index 15d1ba0..62c67a5 100644 Binary files a/reproduction/outputs/Sen3_30_Med_Adherence_CEplot_5y-1.png and b/reproduction/outputs/Sen3_30_Med_Adherence_CEplot_5y-1.png differ diff --git a/reproduction/outputs/Sen3_30_Med_Adherenceceplane.csv b/reproduction/outputs/Sen3_30_Med_Adherenceceplane.csv index 15cb844..9d8264b 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherenceceplane.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherenceceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466645458.453711,12.5452260864825,0,12.5452260864825,0,0,NA,NA,0 -"S1a",37195779,1,90753454325.5885,2439.88583558335,0,2439.88583558335,467242137.557907,12.5616978624888,0,12.5616978624888,291.045221313176,0.0164717760063304,17669.3285047903,17116.0871029401,532.543579003308 -"S1b",37200476,1,87878153021.8125,2362.2857143498,0,2362.2857143498,466988044.397164,12.5532814256776,0,12.5532814256776,213.445100079627,0.00805533919506018,26497.3447934407,24764.4612846515,189.321859673364 -"S1c",37192813,1,88797560537.4716,2387.49245821959,0,2387.49245821959,466783360.164217,12.5503645062883,0,12.5503645062883,238.651843949422,0.00513841980577467,46444.5983337562,41646.3318169583,18.2691463392694 -"S2NoCD",22078563,0.593556763930821,58731887920.9201,2660.13181749736,1402.16728772077,2148.84064315472,270917817.912949,12.270627300923,12.9462418266983,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S2a",22077788,0.593535928947491,63840415722.8595,2891.61286098315,1402.16728772077,2286.20674966379,271190365.071176,12.2834028966659,12.9462418266983,12.552823106619,137.366106509064,0.00759685150450196,18081.9786233362,18119.0018958139,242.484871430788 -"S3NoCD",17243525,0.463572330217334,49933527333.6569,2895.78420500779,1503.34379984433,2148.84064315472,193676014.256469,11.2318110279928,13.6802589756049,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S3a",17245589,0.463627818482614,53097071420.885,3078.87839730408,1503.34379984433,2233.80546820848,193814316.627281,11.2384863530773,13.6802589756049,12.5481852613919,84.9648250537575,0.00295900627738099,28713.9725600581,27428.5057246669,62.9938915299717 -"S3b",17248093,0.463695135641656,55163743514.5954,3198.251743807,1503.34379984433,2289.26436882022,193983109.582457,11.2466409812643,13.6802589756049,12.5518021496191,140.4237256655,0.00657589450465501,21354.3154571739,20395.7175900449,188.379402281949 -"S3c",17249568,0.463734789319606,53820717605.7799,3120.11973898592,1503.34379984433,2253.09904935917,193896397.024298,11.240652347021,13.6802589756049,12.5489285096758,104.258406204442,0.00370225456133788,28160.7881027949,25373.5368288094,80.8627245770767 -"S3d",17250373,0.463756430818419,54140141633.3456,3138.49107108267,1503.34379984433,2261.6538622163,193895422.308672,11.2400712905554,13.6802589756049,12.5486062442593,112.813219061578,0.00337998914478099,33376.7992230897,29382.4638424138,56.1946408922086 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,933240063.269734,12.5454738885578,0,12.5454738885578,0,0,NA,NA,0 +"S1a",74380275,1,181401075128.178,2438.8330794445,0,2438.8330794445,934239601.55953,12.560313894504,0,12.560313894504,288.966086316825,0.014840005946251,19472.1004400827,19152.7317138316,453.034210995655 +"S1b",74383024,1,175747140583.673,2362.73185913594,0,2362.73185913594,933787724.01465,12.5537746894325,0,12.5537746894325,212.864866008269,0.00830080087472673,25643.8949952859,24838.024508073,202.175177728059 +"S1c",74393892,1,177409072797.107,2384.72632668697,0,2384.72632668697,933746980.213024,12.5513930661542,0,12.5513930661542,234.859333559296,0.00591917759642335,39677.6967295607,37796.7045192932,61.0995462618303 +"S2NoCD",44156404,0.593591118938596,117605933754.634,2663.39473102553,1399.82062664894,2149.86699312767,541859031.247822,12.2713577683505,12.9458413561387,12.5454738885578,0,0,NA,NA,0 +"S2a",44164773,0.593703622757395,127735308298.483,2892.24419422426,1399.82062664894,2285.87790540693,542449119.230119,12.2823934639066,12.9458413561387,12.5519499390097,136.010912279254,0.00647605045197786,21002.1390796476,20737.2033810468,187.791610319633 +"S3NoCD",34500334,0.46378531781744,99842281257.7915,2893.95115009007,1506.29023425363,2149.86699312767,387517175.854486,11.2322731673985,13.6812936153544,12.5454738885578,0,0,NA,NA,-1.16415321826935e-10 +"S3a",34507415,0.463880507151998,106095806862.256,3074.57996671892,1506.29023425363,2233.7892707109,387796822.974073,11.2380722512559,13.6812936153544,12.5479308498918,83.9222775832291,0.00245696133404039,34156.9386626129,31147.8193918049,38.925789118628 +"S3b",34499539,0.463774630694015,110363699543.429,3198.99055878484,1506.29023425363,2291.32170213873,388038736.167987,11.2476498937562,13.6812936153544,12.5526313971294,141.454709011058,0.00715750857160558,19763.1211469618,19837.7340923965,216.420719569083 +"S3c",34496334,0.463731546127251,107627143927.157,3119.95888975209,1506.29023425363,2254.59929480501,387776879.328762,11.2411040352509,13.6812936153544,12.5497007285294,104.732301677339,0.00422683997161855,24777.9197652555,25592.925116818,106.609696903499 +"S3d",34507664,0.463883854439712,108255487965.337,3137.14333040154,1506.29023425363,2262.81665451966,387911627.531503,11.2413180889759,13.6812936153544,12.5494283634394,112.949661391986,0.00395447488162048,28562.4930675249,26887.1518929379,84.7740826888476 diff --git a/reproduction/outputs/Sen3_30_Med_Adherenceceplane_5y.csv b/reproduction/outputs/Sen3_30_Med_Adherenceceplane_5y.csv index 9c231fc..33fc538 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherenceceplane_5y.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherenceceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466645458.453711,12.5452260864825,0,12.5452260864825,0,0,NA,NA,0 -"S1a",37197502,1,87609315425.5502,2355.24728046389,0,2355.24728046389,467053611.148306,12.5560477461176,0,12.5560477461176,206.406666193722,0.0108216596351252,19073.4760797469,20089.6428297252,334.67631556245 -"S1b",37190655,1,85474784067.1315,2298.28660095208,0,2298.28660095208,466807667.374783,12.5517463291459,0,12.5517463291459,149.44598668191,0.00652024266343787,22920.3105460975,25093.0398812956,176.566146490048 -"S1c",37195162,1,86086185363.3803,2314.4457702155,0,2314.4457702155,466843146.799544,12.5511792850786,0,12.5511792850786,165.60515594533,0.00595319859612253,27817.8450242182,30805.4976534331,132.054773860844 -"S2NoCD",22074342,0.593443287202261,58922537504.9946,2669.27718638203,1389.16908130145,2148.84064315472,270895360.188654,12.2719562915467,12.9441133485222,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S2a",22077777,0.593535633225147,62347138313.8362,2823.97717459671,1389.16908130145,2240.77881151202,271063504.04804,12.2776629208656,12.9441133485222,12.5485512719299,91.9381683572924,0.00332501681541331,27650.4371139141,27108.8202105676,74.3210751280421 -"S3NoCD",17254548,0.463868670889904,50064966232.8174,2901.55188260031,1497.58386473614,2148.84064315472,193797356.892219,11.2316681313367,13.6817359644516,12.5452262551145,0,0,NA,NA,0.00840271473862231 -"S3a",17251608,0.463789632372499,52066304895.3422,3018.05518044128,1497.58386473614,2202.76269727995,193847859.558584,11.2365096377441,13.6817359644516,12.5476653453204,53.9220541252316,0.00243909020591815,22107.4456346044,24063.4397718265,68.0408588855062 -"S3b",17246874,0.463662364229167,53626126689.0333,3109.32443114232,1497.58386473614,2244.88730628008,193956938.999034,11.2459184776925,13.6817359644516,12.5523390697101,96.0466631253616,0.00711281459564361,13503.3272460367,14580.1753413121,259.602469371515 -"S3c",17246125,0.463642228225923,52687996543.3235,3055.06289345134,1497.58386473614,2219.6969120248,193867413.988793,11.2412158666827,13.6817359644516,12.5502077882919,70.8562688700772,0.00498153317740346,14223.78740575,16078.2641419832,178.228792714886 -"S3d",17255729,0.463900420716114,52823751958.8562,3061.22980714731,1497.58386473614,2222.95987527172,193917113.914449,11.2378395554571,13.6817359644516,12.5480113921325,74.1192321170006,0.00278513701798921,26612.4185769907,25873.7564345888,65.146021497203 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,933240063.269734,12.5454738885578,0,12.5454738885578,0,0,NA,NA,0 +"S1a",74386318,1,175298229824.161,2356.5923752828,0,2356.5923752828,934033198.37721,12.5565187724066,0,12.5565187724066,206.725382155124,0.0110448838488768,18716.8452818222,19145.7366308898,345.518810288631 +"S1b",74385413,1,170952563916.074,2298.20010431446,0,2298.20010431446,933637486.50531,12.551351788627,0,12.551351788627,148.33311118679,0.00587790006926348,25235.7320537735,26468.9578303756,145.561892276281 +"S1c",74390720,1,171904343831.839,2310.83048842435,0,2310.83048842435,933570750.279375,12.5495592767401,0,12.5495592767401,160.963495296681,0.00408538818233062,39399.8044036186,42521.8072883671,43.3059138196986 +"S2NoCD",44157029,0.593599520765188,117807957834.59,2667.93216170838,1393.16700996411,2149.86699312767,541828917.159047,12.2705021019201,12.9471051097595,12.5454738885578,0,0,NA,NA,1.16415321826935e-10 +"S2a",44154576,0.59356654527618,124844786046.661,2827.44841772824,1393.16700996411,2244.50847012452,542208652.492346,12.2797839230151,12.9471051097595,12.551005578354,94.6414769968451,0.00553168979623919,17108.9631709263,17185.879192054,181.943012815085 +"S3NoCD",34491937,0.463672437596811,99999943602.2554,2899.22666860534,1502.02143805571,2149.86699312767,387401839.065729,11.2316637672662,13.6813050189755,12.5454738885578,0,0,NA,NA,1.16415321826935e-10 +"S3a",34494037,0.46370066773416,104115381915.72,3018.35885187112,1502.02143805571,2205.14810935221,387590904.424574,11.2364610852761,13.6813050189755,12.5476292544133,55.2811162245339,0.00215536585552911,25648.1358293407,24833.0802794382,52.4871765519492 +"S3b",34509196,0.463904448997054,107308147372.611,3109.55222986393,1502.02143805571,2247.7621242753,388040453.250984,11.2445521260763,13.6813050189755,12.5508845108531,97.8951311476294,0.00541062229536848,18093.1371297952,16319.0336611223,172.63598362077 +"S3c",34504471,0.463840931188019,105270593424.191,3050.92616618268,1502.02143805571,2220.46684947165,387852045.425155,11.2406315525068,13.6813050189755,12.5492207655628,70.5998563439753,0.00374687700500331,18842.3202175308,16916.049337496,116.743993906188 +"S3d",34501231,0.463797376118965,105602366017.679,3060.82893151492,1502.02143805571,2224.99226339667,387776869.087764,11.2395082102364,13.6813050189755,12.5488060660667,75.1252702689999,0.00333217750890924,22545.3986374188,20600.8589166803,91.4836051765596 diff --git a/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults.csv b/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults.csv index 78cba28..be4d1af 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,0.400733319767278,0.0756570523768302,0.12787617648766,0.0110773590734583,0.842396438441783,0.046107470726434,0.0491632764596596,0.0110600304517264,0.00193027101638251,0.464626221589564 -"S1b",1,1,1,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,0.405990262060088,0.0763712808406,0.128937839397539,0.0111722226350007,0.842428092026923,0.0461200603625631,0.0491383508538841,0.0110450824446697,0.0019243970545918,0.334053051708208 -"S1c",1,1,1,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,0.407947954891178,0.0766530888642384,0.129489210724663,0.0112076760636524,0.842538166986253,0.0460584214654526,0.0491005034611762,0.0110279779725777,0.00192817614834111,0.288617682950729 -"S2NoCD",0.593556763930821,0.582309685946903,0.705357761730891,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535928947491,0.582469204763036,0.706205579755609,0.0223350819017627,0.146861435551105,0.229046748962462,0.0868671748983432,0.40717154949026,0.0764348498798735,0.129245718868216,0.0111517123369551,0.842521478413868,0.0460676071299697,0.0490956905759404,0.0110472695587943,0.00192542928407099,0.310401264733618 -"S3NoCD",0.463572330217334,0.415367575216711,0.586199735331415,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463627818482614,0.415521682993537,0.587418330972747,0.020135761944108,0.139262558345173,0.180514922789748,0.0822286518533507,0.41091282114974,0.0771068690707244,0.130110991228192,0.0112307468065051,0.842479359257107,0.0461006199327869,0.0491419221040822,0.0110143369803305,0.00191704201835805,0.230684563840532 -"S3b",0.463695135641656,0.415568309564907,0.587233190193687,0.022688346451263,0.146674288242097,0.23269825950894,0.087000110491251,0.406420061933482,0.0764673667010533,0.129141145874287,0.0111893784669518,0.842504903342492,0.0460727197764389,0.0491258682896983,0.011035402357133,0.00191563803310912,0.31741923502635 -"S3c",0.463734789319606,0.415536541294178,0.58767782317134,0.0213351323942394,0.142951005888522,0.207202321894185,0.0845726197929377,0.408416061307295,0.0768438830632355,0.129544969634437,0.0111987434083334,0.842454283191634,0.0461336208713429,0.049131868036605,0.0110135739715596,0.00192049474425886,0.273951977879277 -"S3d",0.463756430818419,0.415604987692288,0.587558132403041,0.0207663794232776,0.141381171887563,0.195210605479162,0.0835996238319034,0.409497721665754,0.0769666360150598,0.129714362011153,0.0112324729853736,0.842472623948323,0.0461088404884722,0.0491357216371956,0.0110219486609554,0.00191644348636688,0.254304413340487 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,0.400846084529803,0.0756315299990488,0.127733286815624,0.011087348090606,0.842364170321789,0.046129034765383,0.0491766451495284,0.011049622312511,0.00193589729339196,0.464833027470088 +"S1b",1,1,1,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,0.405907939424458,0.0764086574377509,0.129012461230401,0.0111605841676993,0.842479484739466,0.0460932357315975,0.0491198733047791,0.0110443784905514,0.00192158664025428,0.334294602837872 +"S1c",1,1,1,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,0.407967793915124,0.0766466687883462,0.129330321903309,0.0111360755262005,0.842511866298224,0.0461015049376835,0.0491018031400455,0.0110240858181335,0.00191735547661239,0.288407573923277 +"S2NoCD",0.593591118938596,0.582365621911992,0.705116455867408,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.593703622757395,0.582561633495118,0.706249983323194,0.0223572293275455,0.146520275764833,0.228783458335563,0.0867962070990575,0.406907175011621,0.0764857628938958,0.129161959754734,0.0111849702484567,0.842453436358219,0.0460995130135702,0.049162136254093,0.0110232564059888,0.00191909420686546,0.310203001792548 +"S3NoCD",0.46378531781744,0.415568056211066,0.586617239472126,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.463880507151998,0.415699320053362,0.586708781881545,0.0201156015599614,0.139591817454275,0.180822991967125,0.0824771154683174,0.410893918376555,0.0771596359153628,0.13002154727965,0.0112567726274374,0.842566021780609,0.0460728067506646,0.0490891975121309,0.0110179222026286,0.00191286787636638,0.231194614752874 +"S3b",0.463774630694015,0.415673744808273,0.587660544823951,0.022703218559012,0.147101677876022,0.233250693892965,0.0873282101842993,0.406897958993362,0.0765657243606348,0.12916424164248,0.0111938516834175,0.84245733212396,0.0460718832826625,0.0491420777172941,0.0110558113255998,0.00192827941971036,0.318156004167639 +"S3c",0.463731546127251,0.415538305063213,0.587311603486886,0.0213261904240776,0.143268049986543,0.207485881195491,0.0848645010202161,0.409017522509301,0.0768424095578439,0.12956240035588,0.0112182155362607,0.842485614704402,0.0460621493958521,0.0491521297235465,0.0110349049383035,0.00192076633511325,0.274243522611208 +"S3d",0.463883854439712,0.415752092299157,0.587221087548919,0.0207546147301295,0.141567271736428,0.195481611880112,0.0837050652172602,0.40984416843231,0.0769796311184294,0.1297896347637,0.0112424293950455,0.842510845247546,0.0460587342353947,0.0491389891816906,0.0110270863763496,0.00192123076545521,0.254532916078862 diff --git a/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults_5y.csv b/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults_5y.csv index fc6208a..2a670bd 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults_5y.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherenceclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,0.403047226128249,0.0760263148853383,0.12840956363145,0.0111267149068236,0.842461254812893,0.0461118957155039,0.049118855485952,0.0110334546540076,0.00192729365384067,0.399988053390932 -"S1b",1,1,1,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,0.408631980264935,0.0767122278432579,0.129370859426918,0.0112158820542419,0.8424572166305,0.0461045345921089,0.0491178381114376,0.0110465138362427,0.00192862473289225,0.294526778968184 -"S1c",1,1,1,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,0.409231958715491,0.0769956856216946,0.129978355787239,0.0112124528453459,0.842487284544981,0.0461078639931604,0.0491352633754891,0.0110153793798817,0.00191157483979592,0.26029455677229 -"S2NoCD",0.593443287202261,0.582273174807522,0.705545677347615,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535633225147,0.582295847461883,0.706034831690326,0.0214260856128922,0.143399662052018,0.208913322432459,0.0847853184386878,0.407655221861622,0.0767470760900907,0.129218216541159,0.011199194631369,0.842544394644732,0.046094763613817,0.0491127745862289,0.0109897656237673,0.00191086601779681,0.277612135628334 -"S3NoCD",0.463868670889904,0.415635368247289,0.587073562742789,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463789632372499,0.415622940758265,0.586809647097927,0.0197696669249095,0.138028597361208,0.171429592848262,0.081236444450917,0.411287856148879,0.07722846001244,0.130038331526943,0.0112026643175846,0.842626066479021,0.0461014349785822,0.0490229859734682,0.0109954420436182,0.00190926922852537,0.216839145396673 -"S3b",0.463662364229167,0.415627753354033,0.587309552953142,0.0217273072426316,0.144075656740584,0.212315561616708,0.085323826327292,0.407654369789789,0.0766217806454282,0.129340579136661,0.0111730977587919,0.84257351681126,0.0461000010925949,0.0490636336910152,0.0110096977534996,0.00191076692651309,0.284092335789576 -"S3c",0.463642228225923,0.415569605134916,0.587621281450251,0.0206710534473348,0.140931536559447,0.191763032350927,0.08324285525963,0.409917216243935,0.07702129939584,0.12970969386912,0.0111986612734943,0.842538118936641,0.0460823834781866,0.0491061374122304,0.0110204077894173,0.00191447077751689,0.249320504213185 -"S3d",0.463900420716114,0.415712328288473,0.587409792818855,0.0202416660684579,0.139590000283801,0.18228853527996,0.0822922365025336,0.410444613492492,0.077025066408215,0.129808877075041,0.0112098048644388,0.842570046688464,0.0461323938488098,0.0490485515602565,0.0110024025072699,0.00190357830414835,0.234231338952332 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,0.403687247969445,0.076043339045226,0.128491882068958,0.0111234434267872,0.842404538075766,0.0461249975109299,0.0491350481006971,0.0110626268806794,0.00192774403765099,0.400376813672669 +"S1b",1,1,1,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,0.408261469221123,0.0767148930126932,0.12942550981064,0.0111918986051741,0.842444102006296,0.0461405534347918,0.049119839074542,0.0110326731874807,0.0019206407489528,0.294383825212184 +"S1c",1,1,1,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,0.409414400075708,0.0768280371530212,0.129676147777572,0.0111990850471672,0.842566279080345,0.0460770376386533,0.0490825292231934,0.0110175512447196,0.00191369725957158,0.260088914224771 +"S2NoCD",0.593599520765188,0.582336120728919,0.705468838282451,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.59356654527618,0.582414633463478,0.70594630719989,0.0213965559374253,0.143850474561616,0.209480412096954,0.0850850980302915,0.408667539118558,0.0767385183547775,0.129416522072223,0.0112172729297281,0.842512558981358,0.0461063547945422,0.0490973671326712,0.0110198437844154,0.00191734574481944,0.277927102442024 +"S3NoCD",0.463672437596811,0.415434005363706,0.586089346363954,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.46370066773416,0.415527713942897,0.586531096227929,0.0197899392090461,0.138303277630978,0.171711091371148,0.0814794148216474,0.412123358096292,0.0772548393515772,0.130128312756924,0.0112117859678794,0.842519910814925,0.0460735235689768,0.0491516810272371,0.0110056311963728,0.00190514377766393,0.217315925410359 +"S3b",0.463904448997054,0.415785735654782,0.587675158368244,0.0217415888048102,0.144179021361847,0.212418250542373,0.0853294076058373,0.409418571728946,0.0768062462692041,0.129433160211189,0.0111817841277405,0.842414303912108,0.0460965101654088,0.0491882510131361,0.0110409375550577,0.00191758449244497,0.28441849116625 +"S3c",0.463840931188019,0.415695058927611,0.586925015622923,0.0206753702957292,0.141063374890625,0.191706805465128,0.0833410596328628,0.410579318361524,0.076984479764633,0.129710841719411,0.0112076528740334,0.842489353520781,0.0460832909926345,0.0491418310503537,0.0110238974057143,0.0019169509018325,0.24963076915198 +"S3d",0.463797376118965,0.41566768511288,0.586881023447397,0.02025846993191,0.139712240331005,0.182490438501157,0.0824624734254074,0.411214425863804,0.0771279852307872,0.129855466070449,0.0112227977270353,0.842491682442217,0.0460936959542376,0.0491366016280874,0.011022918093246,0.00191137314896782,0.234585140125143 diff --git a/reproduction/outputs/Sen3_30_Med_Adherences1.csv b/reproduction/outputs/Sen3_30_Med_Adherences1.csv index 69f1321..4385827 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherences1.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherences1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466614758.380329,12.5445924752228,625082.515223931,0,0,NA,0 -"S1NoCD2",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466676158.527093,12.545859678375,625142.41128036,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466645458.453711,12.5452260864825,625112.463252145,0,0,NA,0 -"S1a",37195779,626218800.231142,71281372.3281143,186100281,33119194.6945306,13388772,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,14905588,2814123,4756454,412031,0.209109161526637,0.0394790799908614,0.0667278679499271,0.0057803460643741,527524487,28873365,30786968,6925999,1208772,90753454325.5885,2439.88583558335,467242137.557907,12.5616978624888,625645.007288858,292.777298375314,0.0171053872660547,17116.0871029401,562.492064927472 -"S1b",37200476,626144171.819881,71252444.7802286,188422793,23802096.6205059,13372758,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,15103031,2841048,4796549,415612,0.211965091816623,0.0398729897446037,0.067317676113353,0.00583295073287542,527481440,28877807,30767692,6915814,1204950,87878153021.8125,2362.2857143498,466988044.397164,12.5532814256776,625301.785569528,215.177177141765,0.00868895045478446,24764.4612846515,219.270345597528 -"S1c",37192813,625960445.075725,71159107.171146,189176712,20537776.6325788,13372239,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,15172732,2850944,4816068,416845,0.213222630288317,0.0400643587776213,0.0676802758137028,0.0058579290349644,527395566,28830750,30734973,6903078,1206962,88797560537.4716,2387.49245821959,466783360.164217,12.5503645062883,625130.732856194,240.383921011561,0.00577203106549895,41646.3318169583,48.2176322634332 +"S1NoCD",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,933216569.304974,12.5451309094502,625108.508032418,0,0,NA,0 +"S1NoCD2",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,933263557.234494,12.5458168691499,625139.146903416,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,933240063.269734,12.5454738885578,625123.827467917,0,0,NA,0 +"S1a",74380275,1252107231.24309,142568770.421589,372100831,66270673.1777553,26745802,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,29815042,5625494,9500837,824680,0.209127440124749,0.0394581084157834,0.0666403797402835,0.00578443650430136,1054730269,57758498,61574433,13835312,2423951,181401075128.178,2438.8330794445,934239601.55953,12.560313894504,625576.861645756,290.795639349996,0.0151829850537712,19152.7317138316,468.35361333855 +"S1b",74383024,1252030977.73496,142410669.767258,376764647,47607118.2897207,26748888,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,30192660,5683507,9596337,830158,0.212011221134933,0.0399092779304288,0.0673849579928479,0.00582932445551117,1054810413,57710159,61499603,13827904,2405886,175747140583.673,2362.73185913594,933787724.01465,12.5537746894325,625326.002612489,214.694419041441,0.00864377998224697,24838.024508073,217.494580070954 +"S1c",74393892,1252166866.96087,142379317.946113,378416895,41063273.6656893,26758496,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,30350312,5702044,9621386,828456,0.213165173410135,0.0400482603952217,0.0675757275620708,0.00581865408509366,1054965444,57726777,61483651,13803995,2400849,177409072797.107,2384.72632668697,933746980.213024,12.5513930661542,625184.926981023,236.688886592467,0.00626215670394359,37796.7045192932,76.4189486047253 diff --git a/reproduction/outputs/Sen3_30_Med_Adherences1_5y.csv b/reproduction/outputs/Sen3_30_Med_Adherences1_5y.csv index b3c31be..31ba743 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherences1_5y.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherences1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466614758.380329,12.5445924752228,625082.515223931,0,0,NA,0 -"S1NoCD",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466676158.527093,12.545859678375,625142.41128036,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466645458.453711,12.5452260864825,625112.463252145,0,0,NA,0 -"S1a",37197502,626089852.781592,71222083.952196,122776626,28487982.7184844,16327137,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,14992350,2827989,4776515,413886,0.210501422705671,0.0397066309081624,0.0670650833975313,0.00581120316948039,527456443,28870190,30752817,6907934,1206659,87609315425.5502,2355.24728046389,467053611.148306,12.5560477461176,625447.140025417,204.674642075062,0.0101880677426589,20089.6428297252,304.72874505783 -"S1b",37190655,625992698.014129,71214502.2789584,123717512,20974577.9720441,16327973,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,15197291,2852978,4811387,417126,0.213401631882082,0.0400617558039574,0.0675618988552786,0.00585731819575248,527372066,28861102,30747408,6915037,1207305,85474784067.1315,2298.28660095208,466807667.374783,12.5517463291459,625289.029856345,147.71396256325,0.00588665077097161,25093.0398812956,146.618575985427 -"S1c",37195162,626110981.941873,71210037.1648892,124047387,18535585.0615731,16324587,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,15221449,2863867,4834566,417049,0.213754262826099,0.0402171816505112,0.0678916370848874,0.00585660416149354,527490541,28868640,30764128,6896850,1196858,86086185363.3803,2314.4457702155,466843146.799544,12.5511792850786,625244.518483716,163.87313182667,0.00531960670365628,30805.4976534331,102.107203356223 +"S1NoCD2",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,933216569.304974,12.5451309094502,625108.508032418,0,0,NA,0 +"S1NoCD",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,933263557.234494,12.5458168691499,625139.146903416,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,933240063.269734,12.5454738885578,625123.827467917,0,0,NA,0 +"S1a",74386318,1252092577.05249,142511621.315835,245523949,57058348.8537602,32655914,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,30028808,5656584,9558038,827432,0.210711293035183,0.0396920893031161,0.0670684812350664,0.00580606684816418,1054768469,57752767,61521629,13851433,2413714,175298229824.161,2356.5923752828,934033198.37721,12.5565187724066,625469.346245049,204.895821202494,0.0107019032567237,19145.7366308898,330.199341633706 +"S1b",74385413,1252007175.89227,142455061.307373,247448362,41936465.8685008,32651747,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,30368698,5706469,9627370,832514,0.213180898743035,0.0400580291611207,0.0675818037747859,0.0058440464828673,1054746061,57768304,61498391,13812986,2404656,170952563916.074,2298.20010431446,933637486.50531,12.551351788627,625269.389327037,146.503550234159,0.00553491947711038,26468.9578303756,130.242423621356 +"S1c",74390720,1252048090.68724,142295860.364143,248074520,37009575.8207896,32668233,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,30456632,5715293,9646702,833108,0.214037372008291,0.0401648578207,0.0677932722379522,0.00585475921694439,1054933501,57690667,61453687,13794504,2396041,171904343831.839,2310.83048842435,933570750.279375,12.5495592767401,625167.13334858,159.133934344051,0.00374240759017752,42521.8072883671,27.9864451647736 diff --git a/reproduction/outputs/Sen3_30_Med_Adherences2.csv b/reproduction/outputs/Sen3_30_Med_Adherences2.csv index d5798b5..c2df414 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherences2.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherences2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078563,364522748.573687,50166624.1671238,110968095,9653605.82348446,7738507,0.0172779795723912,0.141222462720366,0.158929640922804,0.0870932535738703,11438971,2125413,3543389,304919,0.228019548652357,0.0423670724368348,0.0706323987078669,0.00607812475051542,298790021,18633807,22502661,5543543,1025792,58731887920.9201,2660.13181749736,270917817.912949,12.270627300923,610871.233228654,0,0,NA,0 -"S2a",22077788,364622606.499305,50226922.8843361,108797477,18511083.7047635,7734136,0.0229898067769556,0.157327004308664,0.269003214018226,0.0973502415391329,11192847,2087413,3500787,300763,0.22284556483333,0.041559643317329,0.0696994121670902,0.00598808333714978,298828425,18622586,22524521,5579724,1036307,63840415722.8595,2891.61286098315,271190365.071176,12.2834028966659,611278.531972313,231.481043485787,0.0127755957429017,18119.0018958139,407.298743659281 +"S2NoCD",44156404,729084497.054691,100330759.79117,221928932,19330951.6588092,15481473,0.0172596709453046,0.141645486548806,0.159259990701265,0.08725337635747,22917076,4253860,7098458,609501,0.228415254182267,0.0423983632622146,0.070750565577046,0.00607491661847899,597619551,37246010,44990133,11123560,2050468,117605933754.634,2663.39473102553,541859031.247822,12.2713577683505,610904.493686498,0,0,NA,0 +"S2a",44164773,729329891.015329,100492048.993736,217625447,37010683.2532179,15485858,0.0230145995823502,0.157180410449991,0.268827891528291,0.0973046709934024,22383331,4181008,7006346,603148,0.222737333193348,0.0416053612386849,0.0697204014661571,0.00600194747783078,597700094,37284225,45068617,11147317,2064302,127735308298.483,2892.24419422426,542449119.230119,12.2823934639066,611227.429001106,228.84946319874,0.0110356955561279,20737.2033810468,322.93531460769 diff --git a/reproduction/outputs/Sen3_30_Med_Adherences2_5y.csv b/reproduction/outputs/Sen3_30_Med_Adherences2_5y.csv index 8aada95..a31217f 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherences2_5y.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherences2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22074342,364499892.795735,50179989.1467565,72492409,9769650.24862608,9434235,0.0208917555301636,0.141988942022567,0.159733364688847,0.0874666663868567,11472370,2126666,3551252,304704,0.228624401779918,0.0423807584688858,0.070770282345299,0.00607222132130921,298757005,18626945,22501053,5562438,1027303,58922537504.9946,2669.27718638203,270895360.188654,12.2719562915467,610928.537390955,0,0,NA,0 -"S2a",22077777,364514085.756087,50214778.8994209,71673455,16290550.2537317,9435494,0.0250429167756047,0.153202361136407,0.241328632393267,0.094789501013715,11245330,2100490,3507989,302346,0.223944628383691,0.0418301154767053,0.0698596922437202,0.00602105608401846,298734836,18629376,22530917,5562183,1028646,62347138313.8362,2823.97717459671,271063504.04804,12.2776629208656,611059.168868685,154.699988214681,0.00570662931890986,27108.8202105676,130.631477730698 +"S2NoCD",44157029,729047563.461063,100380900.154714,145000421,19524492.074223,18863743,0.0209029627109113,0.141781753914197,0.159519185673724,0.0873704363140082,22925265,4254784,7099566,609563,0.228382739790797,0.0423863901742486,0.0707262635527043,0.00607249983871931,597538799,37245010,45040554,11117169,2054803,117807957834.59,2667.93216170838,541828917.159047,12.2705021019201,610857.172934297,0,0,NA,0 +"S2a",44154576,729145856.381239,100448839.030434,143361789,32595478.4145126,18878233,0.0250078581664384,0.153560443203067,0.241814960491553,0.0950258179639202,22519648,4200194,7025459,605531,0.224190226759883,0.0418142612751096,0.0699406689794734,0.00602825284836329,597564735,37286040,45033303,11135908,2066352,124844786046.661,2827.44841772824,542208652.492346,12.2797839230151,611161.747733024,159.516256019854,0.00928182109493747,17185.879192054,304.574798727059 diff --git a/reproduction/outputs/Sen3_30_Med_Adherences3.csv b/reproduction/outputs/Sen3_30_Med_Adherences3.csv index ad3398b..6eeb1f2 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherences3.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherences3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17243525,260017880.24558,41691838.3900313,80059027,7819384.14256,5815322,0.0183575174217772,0.137156256672018,0.154366597029931,0.0863650846874626,9754415,1816466,3038101,261338,0.233964616977224,0.043568863119126,0.0728704014339272,0.00626832517086814,207433146,15294590,18682841,4808648,895345,49933527333.6569,2895.78420500779,193676014.256469,11.2318110279928,558694.76719463,0,0,NA,0 -"S3a",17245589,260114350.889536,41778507.6419587,79305268,11012874.3912697,5816924,0.0210701415875502,0.143601112787989,0.204102307078173,0.090802566674972,9648241,1803612,3027939,260144,0.230937904309204,0.0431708096291264,0.0724759971310943,0.00622674228168777,207442211,15303706,18733677,4824249,900624,53097071420.885,3078.87839730408,193814316.627281,11.2384863530773,558845.439256563,183.094192296297,0.00667532508457569,27428.5057246669,150.672061932506 -"S3b",17248093,260143538.873804,41765340.0149969,77789956,17179218.0534133,5809490,0.0272123567386269,0.156225870536493,0.292983388954392,0.0989344402695251,9481831,1779958,2992091,258625,0.227026309293671,0.0426180655864614,0.0716405277420372,0.00619233555639998,207483725,15287322,18724587,4837601,899769,55163743514.5954,3198.251743807,193983109.582457,11.2466409812643,559133.797319406,302.467538799216,0.0148299532715068,20395.7175900449,439.030124776182 -"S3c",17249568,260123652.106259,41796963.3084409,78552778,14093542.3037528,5811921,0.0239564020668036,0.149872778444183,0.249488678363603,0.0947819160826065,9556493,1794042,3007246,258985,0.228640844778072,0.0429227833314315,0.0719489111639047,0.00619626354404789,207434647,15324709,18727689,4823824,902793,53820717605.7799,3120.11973898592,193896397.024298,11.240652347021,558912.497612064,224.335533978136,0.00884131902823349,25373.5368288094,217.730417433544 -"S3d",17250373,260166499.185349,41788450.6328664,78909896,12694598.7095123,5812281,0.0225871693478081,0.14720440466007,0.229100157335109,0.0931309605323503,9596955,1798651,3013620,260246,0.229655678893537,0.0430418207126676,0.0721160979734865,0.00622770157923294,207483596,15310784,18731510,4829309,900292,54140141633.3456,3138.49107108267,193895422.308672,11.2400712905554,558865.073456686,242.706866074884,0.00826026256261514,29382.4638424138,170.306262055878 +"S3NoCD",34500334,520264617.028559,83469550.1049324,160191877,15617539.1621454,11630123,0.018371612334161,0.136660912007116,0.153889981724535,0.0860423303941354,19525292,3631989,6073558,522424,0.23392113621619,0.0435127420171081,0.0727637562723739,0.00625885726403513,415002016,30608834,37422882,9624470,1788687,99842281257.7915,2893.95115009007,387517175.854486,11.2322731673985,558719.707219835,0,0,NA,0 +"S3a",34507415,520428950.960441,83482575.6405212,158676520,22030097.8695766,11639538,0.0210425232718254,0.143591703407669,0.204088019848658,0.0908272943093332,19287934,3609226,6045313,521405,0.231041434119792,0.043233285177274,0.072414069087079,0.00624567457340066,415152628,30610103,37407716,9641236,1794702,106095806862.256,3074.57996671892,387796822.974073,11.2380722512559,558829.032596078,180.628816628857,0.00579908385742023,31147.8193918049,109.325376242166 +"S3b",34499539,520396932.389974,83618001.6376853,155590263,34428826.1327912,11625591,0.0272677362023387,0.156355277894248,0.293211112522871,0.0990494988470827,18988453,3564625,5980823,516662,0.227085706762959,0.0426298755074946,0.0715255433383203,0.00617883697147755,414988556,30607762,37472866,9688489,1813970,110363699543.429,3198.99055878484,388038736.167987,11.2476498937562,559183.504129024,305.03940869477,0.0153767263576583,19837.7340923965,463.796909188153 +"S3c",34496334,520227370.495019,83568350.903854,157099275,28171360.7955484,11622564,0.0239564406652199,0.14984119401007,0.249428440470547,0.0948714951513754,19145218,3585036,6010150,518449,0.229096515522087,0.0428994465156386,0.0719189733313599,0.00620389171728995,414875686,30589301,37479876,9661353,1804425,107627143927.157,3119.95888975209,387776879.328762,11.2411040352509,558935.242872791,226.007739662019,0.00883086785236209,25592.925116818,215.53565295611 +"S3d",34507664,520495018.435642,83555471.4245087,157877292,25364365.9811382,11630839,0.0225793272116635,0.14694733242596,0.229001602594022,0.0929007877476101,19209915,3595849,6028084,520340,0.229906129095997,0.0430354701935804,0.0721446949820192,0.00622747967462694,415141325,30594930,37472224,9653084,1805226,108255487965.337,3137.14333040154,387911627.531503,11.2413180889759,558928.761118394,243.192180311468,0.00904492157740755,26887.1518929379,209.053898558952 diff --git a/reproduction/outputs/Sen3_30_Med_Adherences3_5y.csv b/reproduction/outputs/Sen3_30_Med_Adherences3_5y.csv index cd986a9..289e0e9 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherences3_5y.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherences3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17254548,260185517.250271,41753986.9530892,52456874,7922835.39457538,7061036,0.0221592886073816,0.13726133321656,0.154573171523665,0.0864947424330528,9767617,1818208,3040076,262205,0.233932558607492,0.043545733777298,0.0728092386342779,0.00627975959025394,207533583,15301679,18724752,4815426,897482,50064966232.8174,2901.55188260031,193797356.892219,11.2316681313367,558681.854684234,0,0,NA,0 -"S3a",17251608,260177737.708618,41735216.681199,52193377,10112285.5219638,7056308,0.0239901655742498,0.141620447019917,0.188896901320193,0.0892874240346538,9673981,1809610,3026757,259927,0.23179419610772,0.0433593052558704,0.0725228533763311,0.00622800168944835,207543323,15307443,18697708,4818609,897810,52066304895.3422,3018.05518044128,193847859.558584,11.2365096377441,558807.426706766,116.503297840971,0.00484150640746606,24063.4397718265,125.572022532346 -"S3b",17246874,260180750.367826,41770771.1055183,51592135,14901907.2426103,7060341,0.0287001627876402,0.151909252445312,0.258476623670136,0.0962303406481393,9537491,1786791,3000373,258790,0.228329301748035,0.0427761076156898,0.0718294855611038,0.00619548055137079,207513062,15306657,18723252,4827550,898750,53626126689.0333,3109.32443114232,193956938.999034,11.2459184776925,559186.599453482,207.772548542013,0.0142503463558015,14580.1753413121,504.744769248064 -"S3c",17246125,260144349.893699,41792941.9345714,51894923,12432862.6252413,7060467,0.0261601311174318,0.146548593395628,0.223441477763239,0.0926749735395,9621451,1801612,3014035,259735,0.23021712649621,0.0431080444832167,0.0721182778833468,0.00621480537088358,207459068,15294280,18748666,4834049,901039,52687996543.3235,3055.06289345134,193867413.988793,11.2412158666827,559005.730440684,153.511010851031,0.00954773534601827,16078.2641419832,323.875756449881 -"S3d",17255729,260233693.824386,41777900.3893267,52047317,11356969.6042882,7062160,0.0251240111093077,0.14426968081771,0.207339855216131,0.0910648854849654,9643777,1802264,3018596,260225,0.23083441030138,0.0431391712653046,0.0722534156065723,0.00622877161310102,207557193,15328896,18715546,4823282,894293,52823751958.8562,3061.22980714731,193917113.914449,11.2378395554571,558830.747965709,159.677924547001,0.00617142412044736,25873.7564345888,148.893281475292 +"S3NoCD",34491937,520096793.944658,83394436.3897572,104866546,15798843.6062051,14116443,0.0221440059305719,0.13704346682043,0.154368086406791,0.0863943143443837,19479590,3630576,6075819,523166,0.233583807784959,0.0435349905481935,0.0728564070102194,0.00627339211880875,414917152,30599570,37365292,9614469,1790750,99999943602.2554,2899.22666860534,387401839.065729,11.2316637672662,558683.961694705,0,0,NA,0 +"S3a",34494037,520214111.090036,83457292.8145667,104351592,20245608.2892442,14129448,0.0240307345372679,0.14177714164029,0.189041590205167,0.0894698764862355,19332282,3614629,6055063,518761,0.231642812126129,0.0433111221092604,0.0725528326620145,0.00621588578427331,414968911,30599997,37426814,9615582,1787056,104115381915.72,3018.35885187112,387590904.424574,11.2364610852761,558804.695411934,119.132183265779,0.00479731800989747,24833.0802794382,120.733717229101 +"S3b",34509196,520537137.764278,83620080.9934994,103218767,29823148.4264926,14132996,0.0287201148667908,0.151759070463881,0.258228121857447,0.0959834805484866,19135380,3582069,6004729,516649,0.228837137834004,0.0428374256212269,0.0718096530002979,0.00617852785911753,415119150,30640730,37483240,9661621,1802895,107308147372.611,3109.55222986393,388040453.250984,11.2445521260763,559118.054073951,210.325561258588,0.0128883588100965,16319.0336611223,434.092379246256 +"S3c",34504471,520423616.303641,83513343.4596301,103824096,24853846.8628113,14121585,0.0261578150769642,0.14647414308412,0.223082059564315,0.0926287674905986,19220385,3595075,6024956,518536,0.23014747349076,0.0430479112806427,0.0721436329861758,0.00620901976281979,415113845,30619979,37421385,9639642,1802009,105270593424.191,3050.92616618268,387852045.425155,11.2406315525068,558980.651459156,151.699497577334,0.00896778524055719,16916.049337496,296.689764450537 +"S3d",34501231,520389346.039061,83507083.8292405,104079260,22711873.9482136,14135933,0.0251554674459531,0.144172895875718,0.20738377463961,0.0911334097630808,19266710,3605577,6035420,519637,0.230719468535119,0.0431768999067536,0.0722743475552509,0.00622266969665208,415086795,30631737,37413709,9638221,1794998,105602366017.679,3060.82893151492,387776869.087764,11.2395082102364,558914.581580307,161.602262909575,0.00784444297022624,20600.8589166803,230.619885601802 diff --git a/reproduction/outputs/Sen3_30_Med_Adherencesall.csv b/reproduction/outputs/Sen3_30_Med_Adherencesall.csv index 33ac403..9a8f40b 100644 --- a/reproduction/outputs/Sen3_30_Med_Adherencesall.csv +++ b/reproduction/outputs/Sen3_30_Med_Adherencesall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37195779,90753454325.5885,2439.88583558335,467242137.557907,12.5616978624888,17116.0871029401,562.492064927472 -"S3b",17248093,55163743514.5954,3198.251743807,193983109.582457,11.2466409812643,20395.7175900449,439.030124776182 -"S2a",22077788,63840415722.8595,2891.61286098315,271190365.071176,12.2834028966659,18119.0018958139,407.298743659281 -"S1b",37200476,87878153021.8125,2362.2857143498,466988044.397164,12.5532814256776,24764.4612846515,219.270345597528 -"S3c",17249568,53820717605.7799,3120.11973898592,193896397.024298,11.240652347021,25373.5368288094,217.730417433544 -"S3d",17250373,54140141633.3456,3138.49107108267,193895422.308672,11.2400712905554,29382.4638424138,170.306262055878 -"S3a",17245589,53097071420.885,3078.87839730408,193814316.627281,11.2384863530773,27428.5057246669,150.672061932506 -"S1c",37192813,88797560537.4716,2387.49245821959,466783360.164217,12.5503645062883,41646.3318169583,48.2176322634332 -"S1NoCD",37196486,79864892644.739,2147.10853720803,466614758.380329,12.5445924752228,NA,0 -"S2NoCD",22078563,58731887920.9201,2660.13181749736,270917817.912949,12.270627300923,NA,0 -"S3NoCD",17243525,49933527333.6569,2895.78420500779,193676014.256469,11.2318110279928,NA,0 +"S1a",74380275,181401075128.178,2438.8330794445,934239601.55953,12.560313894504,19152.7317138316,468.35361333855 +"S3b",34499539,110363699543.429,3198.99055878484,388038736.167987,11.2476498937562,19837.7340923965,463.796909188153 +"S2a",44164773,127735308298.483,2892.24419422426,542449119.230119,12.2823934639066,20737.2033810468,322.93531460769 +"S1b",74383024,175747140583.673,2362.73185913594,933787724.01465,12.5537746894325,24838.024508073,217.494580070954 +"S3c",34496334,107627143927.157,3119.95888975209,387776879.328762,11.2411040352509,25592.925116818,215.53565295611 +"S3d",34507664,108255487965.337,3137.14333040154,387911627.531503,11.2413180889759,26887.1518929379,209.053898558952 +"S3a",34507415,106095806862.256,3074.57996671892,387796822.974073,11.2380722512559,31147.8193918049,109.325376242166 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-"S3c",17246125,52687996543.3235,3055.06289345134,193867413.988793,11.2412158666827,16078.2641419832,323.875756449881 -"S1a",37197502,87609315425.5502,2355.24728046389,467053611.148306,12.5560477461176,20089.6428297252,304.72874505783 -"S3d",17255729,52823751958.8562,3061.22980714731,193917113.914449,11.2378395554571,25873.7564345888,148.893281475292 -"S1b",37190655,85474784067.1315,2298.28660095208,466807667.374783,12.5517463291459,25093.0398812956,146.618575985427 -"S2a",22077777,62347138313.8362,2823.97717459671,271063504.04804,12.2776629208656,27108.8202105676,130.631477730698 -"S3a",17251608,52066304895.3422,3018.05518044128,193847859.558584,11.2365096377441,24063.4397718265,125.572022532346 -"S1c",37195162,86086185363.3803,2314.4457702155,466843146.799544,12.5511792850786,30805.4976534331,102.107203356223 -"S1NoCD",37197623,79996190236.903,2150.57263838883,466676158.527093,12.545859678375,NA,0 -"S2NoCD",22074342,58922537504.9946,2669.27718638203,270895360.188654,12.2719562915467,NA,0 -"S3NoCD",17254548,50064966232.8174,2901.55188260031,193797356.892219,11.2316681313367,NA,0 +"S3b",34509196,107308147372.611,3109.55222986393,388040453.250984,11.2445521260763,16319.0336611223,434.092379246256 +"S1a",74386318,175298229824.161,2356.5923752828,934033198.37721,12.5565187724066,19145.7366308898,330.199341633706 +"S2a",44154576,124844786046.661,2827.44841772824,542208652.492346,12.2797839230151,17185.879192054,304.574798727059 +"S3c",34504471,105270593424.191,3050.92616618268,387852045.425155,11.2406315525068,16916.049337496,296.689764450537 +"S3d",34501231,105602366017.679,3060.82893151492,387776869.087764,11.2395082102364,20600.8589166803,230.619885601802 +"S1b",74385413,170952563916.074,2298.20010431446,933637486.50531,12.551351788627,26468.9578303756,130.242423621356 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a/reproduction/outputs/Sen4_01_Treat_Util_CEplot_5y-1.png and b/reproduction/outputs/Sen4_01_Treat_Util_CEplot_5y-1.png differ diff --git a/reproduction/outputs/Sen4_01_Treat_Utilceplane.csv b/reproduction/outputs/Sen4_01_Treat_Utilceplane.csv index 3a51a45..43c3d0c 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utilceplane.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utilceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466432642.709557,12.5395047801314,0,12.5395047801314,0,0,NA,NA,0 -"S1a",37195779,1,90753454325.5885,2439.88583558335,0,2439.88583558335,466710528.785287,12.5474056823837,0,12.5474056823837,291.045221313176,0.007900902252306,36836.9601368287,34372.2798098499,103.999891302199 -"S1b",37200476,1,87878153021.8125,2362.2857143498,0,2362.2857143498,466602621.887519,12.5429207380981,0,12.5429207380981,213.445100079627,0.00341595796669125,62484.6974584915,53355.6107865744,-42.6472017450724 -"S1c",37192813,1,88797560537.4716,2387.49245821959,0,2387.49245821959,466450152.720691,12.5414055860924,0,12.5414055860924,238.651843949422,0.00190080596105524,125552.975337332,95476.2401140166,-143.611545896623 -"S2NoCD",22078563,0.593556763930821,58731887920.9201,2660.13181749736,1402.16728772077,2148.84064315472,270758372.074819,12.2634055520198,12.9427117186985,12.5395049486864,0,0,NA,NA,0.00839886942412704 -"S2a",22077788,0.593535928947491,63840415722.8595,2891.61286098315,1402.16728772077,2286.20674966379,270883900.09493,12.2695217516778,12.9427117186985,12.5431492862647,137.366106509064,0.00364433757827598,37693.0247427977,37847.2019278165,44.8591712741181 -"S3NoCD",17243525,0.463572330217334,49933527333.6569,2895.78420500779,1503.34379984433,2148.84064315472,193546782.762299,11.2243165340207,13.6760700298808,12.5395049486864,0,0,NA,NA,0.00839886954054236 -"S3a",17245589,0.463627818482614,53097071420.885,3078.87839730408,1503.34379984433,2233.80546820848,193630822.054665,11.2278462657706,13.6760700298808,12.5410053869691,84.9648250537575,0.00150043828268132,56626.6710430259,51871.9849740528,-9.9345120502403 -"S3b",17248093,0.463695135641656,55163743514.5954,3198.251743807,1503.34379984433,2289.26436882022,193698483.397538,11.2301390882771,13.6760700298808,12.5419037501438,140.4237256655,0.00239880145732663,58539.1197077213,51947.5689668394,-20.4752539297333 -"S3c",17249568,0.463734789319606,53820717605.7799,3120.11973898592,1503.34379984433,2253.09904935917,193662077.976417,11.2270682939084,13.6760700298808,12.5403827258063,104.258406204442,0.000877777119869805,118775.488497474,81524.385531405,-60.3611513415817 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+"S1c",74393892,1,177409072797.107,2384.72632668697,0,2384.72632668697,933081226.100791,12.5424440235065,0,12.5424440235065,234.859333559296,0.00269794226511877,87051.2822293315,78383.0291268327,-99.9622203032486 +"S2NoCD",44156404,0.593591118938596,117605933754.634,2663.39473102553,1399.82062664894,2149.86699312767,541539871.750723,12.2641298360873,12.9423045955422,12.5397460812414,0,0,NA,NA,0 +"S2a",44164773,0.593703622757395,127735308298.483,2892.24419422426,1399.82062664894,2285.87790540693,541836400.919553,12.2685200016663,12.9423045955422,12.5422762412,136.010912279254,0.002530159958539,53755.8551664816,52127.7521491541,-9.50291435222607 +"S3NoCD",34500334,0.46378531781744,99842281257.7915,2893.95115009007,1506.29023425363,2149.86699312767,387259112.683023,11.2247931478873,13.6770813396277,12.5397460812414,0,0,NA,NA,0 +"S3a",34507415,0.463880507151998,106095806862.256,3074.57996671892,1506.29023425363,2233.7892707109,387430323.926254,11.2274513731688,13.6770813396277,12.540745748452,83.9222775832291,0.000999667210574984,83950.2153271178,67950.9061508423,-33.9389170544455 +"S3b",34499539,0.463774630694015,110363699543.429,3198.99055878484,1506.29023425363,2291.32170213873,387468229.642479,11.2311132517591,13.6770813396277,12.5427033929871,141.454709011058,0.00295731174566072,47832.1939574397,48264.9359699222,6.41087827191222 +"S3c",34496334,0.463731546127251,107627143927.157,3119.95888975209,1506.29023425363,2254.59929480501,387308369.15042,11.227522586905,13.6770813396277,12.5411436718981,104.732301677339,0.00139759065666389,74937.7517501009,82803.7329985258,-34.85276884411 +"S3d",34507664,0.463883854439712,108255487965.337,3137.14333040154,1506.29023425363,2262.81665451966,387489230.450196,11.2290774145186,13.6770813396277,12.5414918431645,112.949661391986,0.0017457619231287,64699.3498343473,56764.0161642444,-25.6615652355831 diff --git a/reproduction/outputs/Sen4_01_Treat_Utilceplane_5y.csv b/reproduction/outputs/Sen4_01_Treat_Utilceplane_5y.csv index d2d29d8..eb0283c 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utilceplane_5y.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utilceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466432642.709557,12.5395047801314,0,12.5395047801314,0,0,NA,NA,0 -"S1a",37197502,1,87609315425.5502,2355.24728046389,0,2355.24728046389,466595031.540288,12.5437195094522,0,12.5437195094522,206.406666193722,0.00421472932086431,48972.6980026785,56888.5382255813,4.32979984954 -"S1b",37190655,1,85474784067.1315,2298.28660095208,0,2298.28660095208,466468381.960123,12.5426234617305,0,12.5426234617305,149.44598668191,0.00311868159909245,47919.6038240643,59043.7608359928,6.48809327278286 -"S1c",37195162,1,86086185363.3803,2314.4457702155,0,2314.4457702155,466543276.828189,12.5431172158408,0,12.5431172158408,165.60515594533,0.00361243570947423,45843.0735558843,54705.9802113152,15.0166295284871 -"S2NoCD",22074342,0.593443287202261,58922537504.9946,2669.27718638203,1389.16908130145,2148.84064315472,270734518.104213,12.2646699097175,12.9406765536065,12.5395049486864,0,0,NA,NA,0.00839886954054236 -"S2a",22077777,0.593535633225147,62347138313.8362,2823.97717459671,1389.16908130145,2240.77881151202,270793672.348789,12.2654410518228,12.9406765536065,12.5399002224792,91.9381683572924,0.000395273792777928,232593.63518933,200611.517834995,-72.1660798490047 -"S3NoCD",17254548,0.463868670889904,50064966232.8174,2901.55188260031,1497.58386473614,2148.84064315472,193666885.097217,11.224106542647,13.6776068971643,12.5395049486864,0,0,NA,NA,0.00839886954054236 -"S3a",17251608,0.463789632372499,52066304895.3422,3018.05518044128,1497.58386473614,2202.76269727995,193680144.822432,11.2267879505744,13.6776068971643,12.5409424789138,53.9220541252316,0.00143753022734039,37510.205420163,43448.5542660892,17.9628561112331 -"S3b",17246874,0.463662364229167,53626126689.0333,3109.32443114232,1497.58386473614,2244.88730628008,193709816.601909,11.2315899450479,13.6776068971643,12.5434808942014,96.0466631253616,0.0039759455149575,24156.9364479554,27764.4495658514,102.759011492017 -"S3c",17246125,0.463642228225923,52687996543.3235,3055.06289345134,1497.58386473614,2219.6969120248,193660756.996613,11.229233059404,13.6776068971643,12.542437395495,70.8562688700772,0.00293244680858429,24162.8488068927,29944.5058172961,75.7744704285869 -"S3d",17255729,0.463900420716114,52823751958.8562,3061.22980714731,1497.58386473614,2222.95987527172,193728620.747026,11.2269160431892,13.6776068971643,12.5407303789601,74.1192321170006,0.00122543027368671,60484.2508860276,56834.9862000054,-12.839319563238 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,932813979.78259,12.5397460812414,0,12.5397460812414,0,0,NA,NA,0 +"S1a",74386318,1,175298229824.161,2356.5923752828,0,2356.5923752828,933114769.757555,12.5441720311732,0,12.5441720311732,206.725382155124,0.00442594993177714,46707.5735924826,49922.8867922169,14.572114433744 +"S1b",74385413,1,170952563916.074,2298.20010431446,0,2298.20010431446,932959011.793074,12.5422307165664,0,12.5422307165664,148.33311118679,0.0024846353249437,59700.1538606681,67733.7863611725,-24.1013449396705 +"S1c",74390720,1,171904343831.839,2310.83048842435,0,2310.83048842435,932972380.189837,12.5415156647205,0,12.5415156647205,160.963495296681,0.00176958347909029,90961.2330803574,109908.249280705,-72.4843213421991 +"S2NoCD",44157029,0.593599520765188,117807957834.59,2667.93216170838,1393.16700996411,2149.86699312767,541507456.212879,12.2632221523074,12.9436444034196,12.5397460812414,0,0,NA,NA,0 +"S2a",44154576,0.59356654527618,124844786046.661,2827.44841772824,1393.16700996411,2244.50847012452,541668367.876313,12.2675477141104,12.9436444034196,12.5423360272737,94.6414769968451,0.0025899460322627,36541.8722312765,36877.581059697,34.855824616272 +"S3NoCD",34491937,0.463672437596811,99999943602.2554,2899.22666860534,1502.02143805571,2149.86699312767,387141750.418356,11.2241232035868,13.6771443978725,12.5397460812414,0,0,NA,NA,0 +"S3a",34494037,0.46370066773416,104115381915.72,3018.35885187112,1502.02143805571,2205.14810935221,387255176.847052,11.2267281689021,13.6771443978725,12.5408847562723,55.2811162245339,0.00113867503088017,48548.6330387021,45732.7330108349,1.65263531950768 +"S3b",34509196,0.463904448997054,107308147372.611,3109.55222986393,1502.02143805571,2247.7621242753,387545996.216555,11.2302238573322,13.6771443978725,12.5420070727736,97.8951311476294,0.00226099153216808,43297.4337828489,34475.9053760666,15.1544454607647 +"S3c",34504471,0.463840931188019,105270593424.191,3050.92616618268,1502.02143805571,2220.46684947165,387439706.531714,11.228681249213,13.6771443978725,12.5414469710187,70.5998563439753,0.00170088977730387,41507.6022479746,33281.6979072271,14.4446325212484 +"S3d",34501231,0.463797376118965,105602366017.679,3060.82893151492,1502.02143805571,2224.99226339667,387400039.510324,11.2285860035059,13.6771443978725,12.5415094392912,75.1252702689999,0.00176335804977867,42603.5258570596,36210.9585552116,13.0426322199637 diff --git a/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults.csv b/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults.csv index 78cba28..be4d1af 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,0.400733319767278,0.0756570523768302,0.12787617648766,0.0110773590734583,0.842396438441783,0.046107470726434,0.0491632764596596,0.0110600304517264,0.00193027101638251,0.464626221589564 -"S1b",1,1,1,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,0.405990262060088,0.0763712808406,0.128937839397539,0.0111722226350007,0.842428092026923,0.0461200603625631,0.0491383508538841,0.0110450824446697,0.0019243970545918,0.334053051708208 -"S1c",1,1,1,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,0.407947954891178,0.0766530888642384,0.129489210724663,0.0112076760636524,0.842538166986253,0.0460584214654526,0.0491005034611762,0.0110279779725777,0.00192817614834111,0.288617682950729 -"S2NoCD",0.593556763930821,0.582309685946903,0.705357761730891,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535928947491,0.582469204763036,0.706205579755609,0.0223350819017627,0.146861435551105,0.229046748962462,0.0868671748983432,0.40717154949026,0.0764348498798735,0.129245718868216,0.0111517123369551,0.842521478413868,0.0460676071299697,0.0490956905759404,0.0110472695587943,0.00192542928407099,0.310401264733618 -"S3NoCD",0.463572330217334,0.415367575216711,0.586199735331415,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463627818482614,0.415521682993537,0.587418330972747,0.020135761944108,0.139262558345173,0.180514922789748,0.0822286518533507,0.41091282114974,0.0771068690707244,0.130110991228192,0.0112307468065051,0.842479359257107,0.0461006199327869,0.0491419221040822,0.0110143369803305,0.00191704201835805,0.230684563840532 -"S3b",0.463695135641656,0.415568309564907,0.587233190193687,0.022688346451263,0.146674288242097,0.23269825950894,0.087000110491251,0.406420061933482,0.0764673667010533,0.129141145874287,0.0111893784669518,0.842504903342492,0.0460727197764389,0.0491258682896983,0.011035402357133,0.00191563803310912,0.31741923502635 -"S3c",0.463734789319606,0.415536541294178,0.58767782317134,0.0213351323942394,0.142951005888522,0.207202321894185,0.0845726197929377,0.408416061307295,0.0768438830632355,0.129544969634437,0.0111987434083334,0.842454283191634,0.0461336208713429,0.049131868036605,0.0110135739715596,0.00192049474425886,0.273951977879277 -"S3d",0.463756430818419,0.415604987692288,0.587558132403041,0.0207663794232776,0.141381171887563,0.195210605479162,0.0835996238319034,0.409497721665754,0.0769666360150598,0.129714362011153,0.0112324729853736,0.842472623948323,0.0461088404884722,0.0491357216371956,0.0110219486609554,0.00191644348636688,0.254304413340487 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,0.400846084529803,0.0756315299990488,0.127733286815624,0.011087348090606,0.842364170321789,0.046129034765383,0.0491766451495284,0.011049622312511,0.00193589729339196,0.464833027470088 +"S1b",1,1,1,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,0.405907939424458,0.0764086574377509,0.129012461230401,0.0111605841676993,0.842479484739466,0.0460932357315975,0.0491198733047791,0.0110443784905514,0.00192158664025428,0.334294602837872 +"S1c",1,1,1,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,0.407967793915124,0.0766466687883462,0.129330321903309,0.0111360755262005,0.842511866298224,0.0461015049376835,0.0491018031400455,0.0110240858181335,0.00191735547661239,0.288407573923277 +"S2NoCD",0.593591118938596,0.582365621911992,0.705116455867408,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.593703622757395,0.582561633495118,0.706249983323194,0.0223572293275455,0.146520275764833,0.228783458335563,0.0867962070990575,0.406907175011621,0.0764857628938958,0.129161959754734,0.0111849702484567,0.842453436358219,0.0460995130135702,0.049162136254093,0.0110232564059888,0.00191909420686546,0.310203001792548 +"S3NoCD",0.46378531781744,0.415568056211066,0.586617239472126,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.463880507151998,0.415699320053362,0.586708781881545,0.0201156015599614,0.139591817454275,0.180822991967125,0.0824771154683174,0.410893918376555,0.0771596359153628,0.13002154727965,0.0112567726274374,0.842566021780609,0.0460728067506646,0.0490891975121309,0.0110179222026286,0.00191286787636638,0.231194614752874 +"S3b",0.463774630694015,0.415673744808273,0.587660544823951,0.022703218559012,0.147101677876022,0.233250693892965,0.0873282101842993,0.406897958993362,0.0765657243606348,0.12916424164248,0.0111938516834175,0.84245733212396,0.0460718832826625,0.0491420777172941,0.0110558113255998,0.00192827941971036,0.318156004167639 +"S3c",0.463731546127251,0.415538305063213,0.587311603486886,0.0213261904240776,0.143268049986543,0.207485881195491,0.0848645010202161,0.409017522509301,0.0768424095578439,0.12956240035588,0.0112182155362607,0.842485614704402,0.0460621493958521,0.0491521297235465,0.0110349049383035,0.00192076633511325,0.274243522611208 +"S3d",0.463883854439712,0.415752092299157,0.587221087548919,0.0207546147301295,0.141567271736428,0.195481611880112,0.0837050652172602,0.40984416843231,0.0769796311184294,0.1297896347637,0.0112424293950455,0.842510845247546,0.0460587342353947,0.0491389891816906,0.0110270863763496,0.00192123076545521,0.254532916078862 diff --git a/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults_5y.csv b/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults_5y.csv index fc6208a..2a670bd 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults_5y.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utilclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,0.403047226128249,0.0760263148853383,0.12840956363145,0.0111267149068236,0.842461254812893,0.0461118957155039,0.049118855485952,0.0110334546540076,0.00192729365384067,0.399988053390932 -"S1b",1,1,1,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,0.408631980264935,0.0767122278432579,0.129370859426918,0.0112158820542419,0.8424572166305,0.0461045345921089,0.0491178381114376,0.0110465138362427,0.00192862473289225,0.294526778968184 -"S1c",1,1,1,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,0.409231958715491,0.0769956856216946,0.129978355787239,0.0112124528453459,0.842487284544981,0.0461078639931604,0.0491352633754891,0.0110153793798817,0.00191157483979592,0.26029455677229 -"S2NoCD",0.593443287202261,0.582273174807522,0.705545677347615,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535633225147,0.582295847461883,0.706034831690326,0.0214260856128922,0.143399662052018,0.208913322432459,0.0847853184386878,0.407655221861622,0.0767470760900907,0.129218216541159,0.011199194631369,0.842544394644732,0.046094763613817,0.0491127745862289,0.0109897656237673,0.00191086601779681,0.277612135628334 -"S3NoCD",0.463868670889904,0.415635368247289,0.587073562742789,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463789632372499,0.415622940758265,0.586809647097927,0.0197696669249095,0.138028597361208,0.171429592848262,0.081236444450917,0.411287856148879,0.07722846001244,0.130038331526943,0.0112026643175846,0.842626066479021,0.0461014349785822,0.0490229859734682,0.0109954420436182,0.00190926922852537,0.216839145396673 -"S3b",0.463662364229167,0.415627753354033,0.587309552953142,0.0217273072426316,0.144075656740584,0.212315561616708,0.085323826327292,0.407654369789789,0.0766217806454282,0.129340579136661,0.0111730977587919,0.84257351681126,0.0461000010925949,0.0490636336910152,0.0110096977534996,0.00191076692651309,0.284092335789576 -"S3c",0.463642228225923,0.415569605134916,0.587621281450251,0.0206710534473348,0.140931536559447,0.191763032350927,0.08324285525963,0.409917216243935,0.07702129939584,0.12970969386912,0.0111986612734943,0.842538118936641,0.0460823834781866,0.0491061374122304,0.0110204077894173,0.00191447077751689,0.249320504213185 -"S3d",0.463900420716114,0.415712328288473,0.587409792818855,0.0202416660684579,0.139590000283801,0.18228853527996,0.0822922365025336,0.410444613492492,0.077025066408215,0.129808877075041,0.0112098048644388,0.842570046688464,0.0461323938488098,0.0490485515602565,0.0110024025072699,0.00190357830414835,0.234231338952332 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,0.403687247969445,0.076043339045226,0.128491882068958,0.0111234434267872,0.842404538075766,0.0461249975109299,0.0491350481006971,0.0110626268806794,0.00192774403765099,0.400376813672669 +"S1b",1,1,1,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,0.408261469221123,0.0767148930126932,0.12942550981064,0.0111918986051741,0.842444102006296,0.0461405534347918,0.049119839074542,0.0110326731874807,0.0019206407489528,0.294383825212184 +"S1c",1,1,1,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,0.409414400075708,0.0768280371530212,0.129676147777572,0.0111990850471672,0.842566279080345,0.0460770376386533,0.0490825292231934,0.0110175512447196,0.00191369725957158,0.260088914224771 +"S2NoCD",0.593599520765188,0.582336120728919,0.705468838282451,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.59356654527618,0.582414633463478,0.70594630719989,0.0213965559374253,0.143850474561616,0.209480412096954,0.0850850980302915,0.408667539118558,0.0767385183547775,0.129416522072223,0.0112172729297281,0.842512558981358,0.0461063547945422,0.0490973671326712,0.0110198437844154,0.00191734574481944,0.277927102442024 +"S3NoCD",0.463672437596811,0.415434005363706,0.586089346363954,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.46370066773416,0.415527713942897,0.586531096227929,0.0197899392090461,0.138303277630978,0.171711091371148,0.0814794148216474,0.412123358096292,0.0772548393515772,0.130128312756924,0.0112117859678794,0.842519910814925,0.0460735235689768,0.0491516810272371,0.0110056311963728,0.00190514377766393,0.217315925410359 +"S3b",0.463904448997054,0.415785735654782,0.587675158368244,0.0217415888048102,0.144179021361847,0.212418250542373,0.0853294076058373,0.409418571728946,0.0768062462692041,0.129433160211189,0.0111817841277405,0.842414303912108,0.0460965101654088,0.0491882510131361,0.0110409375550577,0.00191758449244497,0.28441849116625 +"S3c",0.463840931188019,0.415695058927611,0.586925015622923,0.0206753702957292,0.141063374890625,0.191706805465128,0.0833410596328628,0.410579318361524,0.076984479764633,0.129710841719411,0.0112076528740334,0.842489353520781,0.0460832909926345,0.0491418310503537,0.0110238974057143,0.0019169509018325,0.24963076915198 +"S3d",0.463797376118965,0.41566768511288,0.586881023447397,0.02025846993191,0.139712240331005,0.182490438501157,0.0824624734254074,0.411214425863804,0.0771279852307872,0.129855466070449,0.0112227977270353,0.842491682442217,0.0460936959542376,0.0491366016280874,0.011022918093246,0.00191137314896782,0.234585140125143 diff --git a/reproduction/outputs/Sen4_01_Treat_Utils1.csv b/reproduction/outputs/Sen4_01_Treat_Utils1.csv index 2ada274..32fd18a 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utils1.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utils1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466402566.389403,12.5388878505728,624797.283991434,0,0,NA,0 -"S1NoCD2",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466462719.029711,12.5401216908325,624855.511903238,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466432642.709557,12.5395047801314,624826.397947336,0,0,NA,0 -"S1a",37195779,626218800.231142,71281372.3281143,186100281,33119194.6945306,13388772,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,14905588,2814123,4756454,412031,0.209109161526637,0.0394790799908614,0.0667278679499271,0.0057803460643741,527524487,28873365,30786968,6925999,1208772,90753454325.5885,2439.88583558335,466710528.785287,12.5474056823837,624930.3982836,292.777298375314,0.00851783181083654,34372.2798098499,133.114292166545 -"S1b",37200476,626144171.819881,71252444.7802286,188422793,23802096.6205059,13372758,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,15103031,2841048,4796549,415612,0.211965091816623,0.0398729897446037,0.067317676113353,0.00583295073287542,527481440,28877807,30767692,6915814,1204950,87878153021.8125,2362.2857143498,466602621.887519,12.5429207380981,624783.751190553,215.177177141765,0.0040328875252218,53355.6107865744,-13.5328008807264 -"S1c",37192813,625960445.075725,71159107.171146,189176712,20537776.6325788,13372239,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,15172732,2850944,4816068,416845,0.213222630288317,0.0400643587776213,0.0676802758137028,0.0058579290349644,527395566,28830750,30734973,6903078,1206962,88797560537.4716,2387.49245821959,466450152.720691,12.5414055860924,624682.786846401,240.383921011561,0.00251773551958578,95476.2401140166,-114.497145032277 +"S1NoCD",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,932792067.651946,12.5394243789581,624823.18150781,0,0,NA,0 +"S1NoCD2",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,932835891.913233,12.5400677849173,624851.692691782,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,932813979.78259,12.5397460812414,624837.437099796,0,0,NA,0 +"S1a",74380275,1252107231.24309,142568770.421589,372100831,66270673.1777553,26745802,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,29815042,5625494,9500837,824680,0.209127440124749,0.0394581084157834,0.0666403797402835,0.00578443650430136,1054730269,57758498,61574433,13835312,2423951,181401075128.178,2438.8330794445,933176477.052734,12.5460207972172,624862.206781415,290.795639349996,0.00659641825909496,44083.8691435393,39.0252736047842 +"S1b",74383024,1252030977.73496,142410669.767258,376764647,47607118.2897207,26748888,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,30192660,5683507,9596337,830158,0.212011221134933,0.0399092779304288,0.0673849579928479,0.00582932445551117,1054810413,57710159,61499603,13827904,2405886,175747140583.673,2362.73185913594,933016458.991957,12.5434058581963,624807.56105068,214.694419041441,0.00398147923820957,53923.2798154653,-15.6204571308335 +"S1c",74393892,1252166866.96087,142379317.946113,378416895,41063273.6656893,26758496,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,30350312,5702044,9621386,828456,0.213165173410135,0.0400482603952217,0.0675757275620708,0.00581865408509366,1054965444,57726777,61483651,13803995,2400849,177409072797.107,2384.72632668697,933081226.100791,12.5424440235065,624737.47484864,236.688886592467,0.00301964454843251,78383.0291268327,-85.7066591706825 diff --git a/reproduction/outputs/Sen4_01_Treat_Utils1_5y.csv b/reproduction/outputs/Sen4_01_Treat_Utils1_5y.csv index dd55be8..b50c0dc 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utils1_5y.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utils1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466402566.389403,12.5388878505728,624797.283991434,0,0,NA,0 -"S1NoCD",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466462719.029711,12.5401216908325,624855.511903238,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466432642.709557,12.5395047801314,624826.397947336,0,0,NA,0 -"S1a",37197502,626089852.781592,71222083.952196,122776626,28487982.7184844,16327137,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,14992350,2827989,4776515,413886,0.210501422705671,0.0397066309081624,0.0670650833975313,0.00581120316948039,527456443,28870190,30752817,6907934,1206659,87609315425.5502,2355.24728046389,466595031.540288,12.5437195094522,624830.728192148,204.674642075062,0.00359781861969211,56888.5382255813,-24.7837110904511 -"S1b",37190655,625992698.014129,71214502.2789584,123717512,20974577.9720441,16327973,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,15197291,2852978,4811387,417126,0.213401631882082,0.0400617558039574,0.0675618988552786,0.00585731819575248,527372066,28861102,30747408,6915037,1207305,85474784067.1315,2298.28660095208,466468381.960123,12.5426234617305,624832.886485571,147.71396256325,0.00250177089792025,59043.7608359928,-22.6254176672082 -"S1c",37195162,626110981.941873,71210037.1648892,124047387,18535585.0615731,16324587,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,15221449,2863867,4834566,417049,0.213754262826099,0.0402171816505112,0.0678916370848874,0.00585660416149354,527490541,28868640,30764128,6896850,1196858,86086185363.3803,2314.4457702155,466543276.828189,12.5431172158408,624841.415021827,163.87313182667,0.00299552500830202,54705.9802113152,-14.096881411504 +"S1NoCD2",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,932792067.651946,12.5394243789581,624823.18150781,0,0,NA,0 +"S1NoCD",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,932835891.913233,12.5400677849173,624851.692691782,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,932813979.78259,12.5397460812414,624837.437099796,0,0,NA,0 +"S1a",74386318,1252092577.05249,142511621.315835,245523949,57058348.8537602,32655914,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,30028808,5656584,9558038,827432,0.210711293035183,0.0396920893031161,0.0670684812350664,0.00580606684816418,1054768469,57752767,61521629,13851433,2413714,175298229824.161,2356.5923752828,933114769.757555,12.5441720311732,624852.009183377,204.895821202494,0.00410424625593642,49922.8867922169,0.316491594421677 +"S1b",74385413,1252007175.89227,142455061.307373,247448362,41936465.8685008,32651747,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,30368698,5706469,9627370,832514,0.213180898743035,0.0400580291611207,0.0675818037747859,0.0058440464828673,1054746061,57768304,61498391,13812986,2404656,170952563916.074,2298.20010431446,932959011.793074,12.5422307165664,624813.335724003,146.503550234159,0.00216293164910297,67733.7863611725,-38.3569677789928 +"S1c",74390720,1252048090.68724,142295860.364143,248074520,37009575.8207896,32668233,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,30456632,5715293,9646702,833108,0.214037372008291,0.0401648578207,0.0677932722379522,0.00585475921694439,1054933501,57690667,61453687,13794504,2396041,171904343831.839,2310.83048842435,932972380.189837,12.5415156647205,624764.952747601,159.133934344051,0.00144787980324956,109908.249280705,-86.7399441815214 diff --git a/reproduction/outputs/Sen4_01_Treat_Utils2.csv b/reproduction/outputs/Sen4_01_Treat_Utils2.csv index 811fb2c..11c14e4 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utils2.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utils2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078563,364522748.573687,50166624.1671238,110968095,9653605.82348446,7738507,0.0172779795723912,0.141222462720366,0.158929640922804,0.0870932535738703,11438971,2125413,3543389,304919,0.228019548652357,0.0423670724368348,0.0706323987078669,0.00607812475051542,298790021,18633807,22502661,5543543,1025792,58731887920.9201,2660.13181749736,270758372.074819,12.2634055520198,610510.145783492,0,0,NA,0 -"S2a",22077788,364622606.499305,50226922.8843361,108797477,18511083.7047635,7734136,0.0229898067769556,0.157327004308664,0.269003214018226,0.0973502415391329,11192847,2087413,3500787,300763,0.22284556483333,0.041559643317329,0.0696994121670902,0.00598808333714978,298828425,18622586,22524521,5579724,1036307,63840415722.8595,2891.61286098315,270883900.09493,12.2695217516778,610584.474722905,231.481043485787,0.00611619965796351,37847.2019278165,74.3289394123713 +"S2NoCD",44156404,729084497.054691,100330759.79117,221928932,19330951.6588092,15481473,0.0172596709453046,0.141645486548806,0.159259990701265,0.08725337635747,22917076,4253860,7098458,609501,0.228415254182267,0.0423983632622146,0.070750565577046,0.00607491661847899,597619551,37246010,44990133,11123560,2050468,117605933754.634,2663.39473102553,541539871.750723,12.2641298360873,610543.097073338,0,0,NA,0 +"S2a",44164773,729329891.015329,100492048.993736,217625447,37010683.2532179,15485858,0.0230145995823502,0.157180410449991,0.268827891528291,0.0973046709934024,22383331,4181008,7006346,603148,0.222737333193348,0.0416053612386849,0.0697204014661571,0.00600194747783078,597700094,37284225,45068617,11147317,2064302,127735308298.483,2892.24419422426,541836400.919553,12.2685200016663,610533.755889092,228.84946319874,0.00439016557905525,52127.7521491541,-9.34118424588814 diff --git a/reproduction/outputs/Sen4_01_Treat_Utils2_5y.csv b/reproduction/outputs/Sen4_01_Treat_Utils2_5y.csv index d7bf13c..11000c8 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utils2_5y.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utils2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22074342,364499892.795735,50179989.1467565,72492409,9769650.24862608,9434235,0.0208917555301636,0.141988942022567,0.159733364688847,0.0874666663868567,11472370,2126666,3551252,304704,0.228624401779918,0.0423807584688858,0.070770282345299,0.00607222132130921,298757005,18626945,22501053,5562438,1027303,58922537504.9946,2669.27718638203,270734518.104213,12.2646699097175,610564.218299492,0,0,NA,0 -"S2a",22077777,364514085.756087,50214778.8994209,71673455,16290550.2537317,9435494,0.0250429167756047,0.153202361136407,0.241328632393267,0.094789501013715,11245330,2100490,3507989,302346,0.223944628383691,0.0418301154767053,0.0698596922437202,0.00602105608401846,298734836,18629376,22530917,5562183,1028646,62347138313.8362,2823.97717459671,270793672.348789,12.2654410518228,610448.075416543,154.699988214681,0.000771142105319811,200611.517834995,-116.142882948858 +"S2NoCD",44157029,729047563.461063,100380900.154714,145000421,19524492.074223,18863743,0.0209029627109113,0.141781753914197,0.159519185673724,0.0873704363140082,22925265,4254784,7099566,609563,0.228382739790797,0.0423863901742486,0.0707262635527043,0.00607249983871931,597538799,37245010,45040554,11117169,2054803,117807957834.59,2667.93216170838,541507456.212879,12.2632221523074,610493.17545366,0,0,NA,0 +"S2a",44154576,729145856.381239,100448839.030434,143361789,32595478.4145126,18878233,0.0250078581664384,0.153560443203067,0.241814960491553,0.0950258179639202,22519648,4200194,7025459,605531,0.224190226759883,0.0418142612751096,0.0699406689794734,0.00602825284836329,597564735,37286040,45033303,11135908,2066352,124844786046.661,2827.44841772824,541668367.876313,12.2675477141104,610549.937287791,159.516256019854,0.0043255618030269,36877.581059697,56.7618341315538 diff --git a/reproduction/outputs/Sen4_01_Treat_Utils3.csv b/reproduction/outputs/Sen4_01_Treat_Utils3.csv index 3a1fa30..5747b7f 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utils3.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utils3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17243525,260017880.24558,41691838.3900313,80059027,7819384.14256,5815322,0.0183575174217772,0.137156256672018,0.154366597029931,0.0863650846874626,9754415,1816466,3038101,261338,0.233964616977224,0.043568863119126,0.0728704014339272,0.00626832517086814,207433146,15294590,18682841,4808648,895345,49933527333.6569,2895.78420500779,193546782.762299,11.2243165340207,558320.042496025,0,0,NA,0 -"S3a",17245589,260114350.889536,41778507.6419587,79305268,11012874.3912697,5816924,0.0210701415875502,0.143601112787989,0.204102307078173,0.090802566674972,9648241,1803612,3027939,260144,0.230937904309204,0.0431708096291264,0.0724759971310943,0.00622674228168777,207442211,15303706,18733677,4824249,900624,53097071420.885,3078.87839730408,193630822.054665,11.2278462657706,558313.434891227,183.094192296297,0.00352973174995874,51871.9849740528,-6.60760479839519 -"S3b",17248093,260143538.873804,41765340.0149969,77789956,17179218.0534133,5809490,0.0272123567386269,0.156225870536493,0.292983388954392,0.0989344402695251,9481831,1779958,2992091,258625,0.227026309293671,0.0426180655864614,0.0716405277420372,0.00619233555639998,207483725,15287322,18724587,4837601,899769,55163743514.5954,3198.251743807,193698483.397538,11.2301390882771,558308.702670047,302.467538799216,0.00582255425643297,51947.5689668394,-11.3398259775713 -"S3c",17249568,260123652.106259,41796963.3084409,78552778,14093542.3037528,5811921,0.0239564020668036,0.149872778444183,0.249488678363603,0.0947819160826065,9556493,1794042,3007246,258985,0.228640844778072,0.0429227833314315,0.0719489111639047,0.00619626354404789,207434647,15324709,18727689,4823824,902793,53820717605.7799,3120.11973898592,193662077.976417,11.2270682939084,558233.294956434,224.335533978136,0.00275175988774201,81524.385531405,-86.7475395910442 -"S3d",17250373,260166499.185349,41788450.6328664,78909896,12694598.7095123,5812281,0.0225871693478081,0.14720440466007,0.229100157335109,0.0931309605323503,9596955,1798651,3013620,260246,0.229655678893537,0.0430418207126676,0.0721160979734865,0.00622770157923294,207483596,15310784,18731510,4829309,900292,54140141633.3456,3138.49107108267,193684186.470557,11.2278259995049,558252.808904162,242.706866074884,0.0035094654842478,69157.7868949762,-67.2335918624885 +"S3NoCD",34500334,520264617.028559,83469550.1049324,160191877,15617539.1621454,11630123,0.018371612334161,0.136660912007116,0.153889981724535,0.0860423303941354,19525292,3631989,6073558,522424,0.23392113621619,0.0435127420171081,0.0727637562723739,0.00625885726403513,415002016,30608834,37422882,9624470,1788687,99842281257.7915,2893.95115009007,387259112.683023,11.2247931478873,558345.706244274,0,0,NA,0 +"S3a",34507415,520428950.960441,83482575.6405212,158676520,22030097.8695766,11639538,0.0210425232718254,0.143591703407669,0.204088019848658,0.0908272943093332,19287934,3609226,6045313,521405,0.231041434119792,0.043233285177274,0.072414069087079,0.00624567457340066,415152628,30610103,37407716,9641236,1794702,106095806862.256,3074.57996671892,387430323.926254,11.2274513731688,558297.988691719,180.628816628857,0.00265822528146842,67950.9061508423,-47.7175525553757 +"S3b",34499539,520396932.389974,83618001.6376853,155590263,34428826.1327912,11625591,0.0272677362023387,0.156355277894248,0.293211112522871,0.0990494988470827,18988453,3564625,5980823,516662,0.227085706762959,0.0426298755074946,0.0715255433383203,0.00617883697147755,414988556,30607762,37472866,9688489,1813970,110363699543.429,3198.99055878484,387468229.642479,11.2311132517591,558356.672029168,305.03940869477,0.00632010387178106,48264.9359699222,10.9657848943025 +"S3c",34496334,520227370.495019,83568350.903854,157099275,28171360.7955484,11622564,0.0239564406652199,0.14984119401007,0.249428440470547,0.0948714951513754,19145218,3585036,6010150,518449,0.229096515522087,0.0428994465156386,0.0719189733313599,0.00620389171728995,414875686,30589301,37479876,9661353,1804425,107627143927.157,3119.95888975209,387308369.15042,11.227522586905,558256.1704555,226.007739662019,0.00272943901775591,82803.7329985258,-89.5357887741411 +"S3d",34507664,520495018.435642,83555471.4245087,157877292,25364365.9811382,11630839,0.0225793272116635,0.14694733242596,0.229001602594022,0.0929007877476101,19209915,3595849,6028084,520340,0.229906129095997,0.0430354701935804,0.0721446949820192,0.00622747967462694,415141325,30594930,37472224,9653084,1805226,108255487965.337,3137.14333040154,387489230.450196,11.2290774145186,558316.727395528,243.192180311468,0.00428426663130743,56764.0161642444,-28.9788487460464 diff --git a/reproduction/outputs/Sen4_01_Treat_Utils3_5y.csv b/reproduction/outputs/Sen4_01_Treat_Utils3_5y.csv index af0fa75..9460ef2 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utils3_5y.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utils3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17254548,260185517.250271,41753986.9530892,52456874,7922835.39457538,7061036,0.0221592886073816,0.13726133321656,0.154573171523665,0.0864947424330528,9767617,1818208,3040076,262205,0.233932558607492,0.043545733777298,0.0728092386342779,0.00627975959025394,207533583,15301679,18724752,4815426,897482,50064966232.8174,2901.55188260031,193666885.097217,11.224106542647,558303.77524975,0,0,NA,0 -"S3a",17251608,260177737.708618,41735216.681199,52193377,10112285.5219638,7056308,0.0239901655742498,0.141620447019917,0.188896901320193,0.0892874240346538,9673981,1809610,3026757,259927,0.23179419610772,0.0433593052558704,0.0725228533763311,0.00622800168944835,207543323,15307443,18697708,4818609,897810,52066304895.3422,3018.05518044128,193680144.822432,11.2267879505744,558321.342348276,116.503297840971,0.00268140792734961,43448.5542660892,17.5670985265169 -"S3b",17246874,260180750.367826,41770771.1055183,51592135,14901907.2426103,7060341,0.0287001627876402,0.151909252445312,0.258476623670136,0.0962303406481393,9537491,1786791,3000373,258790,0.228329301748035,0.0427761076156898,0.0718294855611038,0.00619548055137079,207513062,15306657,18723252,4827550,898750,53626126689.0333,3109.32443114232,193709816.601909,11.2315899450479,558470.172821255,207.772548542013,0.00748340240094514,27764.4495658514,166.39757150528 -"S3c",17246125,260144349.893699,41792941.9345714,51894923,12432862.6252413,7060467,0.0261601311174318,0.146548593395628,0.223441477763239,0.0926749735395,9621451,1801612,3014035,259735,0.23021712649621,0.0431080444832167,0.0721182778833468,0.00621480537088358,207459068,15294280,18748666,4834049,901039,52687996543.3235,3055.06289345134,193660756.996613,11.229233059404,558406.590076747,153.511010851031,0.00512651675695253,29944.5058172961,102.814826996648 -"S3d",17255729,260233693.824386,41777900.3893267,52047317,11356969.6042882,7062160,0.0251240111093077,0.14426968081771,0.207339855216131,0.0910648854849654,9643777,1802264,3018596,260225,0.23083441030138,0.0431391712653046,0.0722534156065723,0.00622877161310102,207557193,15328896,18715546,4823282,894293,52823751958.8562,3061.22980714731,193728620.747026,11.2269160431892,558284.572352315,159.677924547001,0.00280950054223794,56834.9862000054,-19.2028974350542 +"S3NoCD",34491937,520096793.944658,83394436.3897572,104866546,15798843.6062051,14116443,0.0221440059305719,0.13704346682043,0.154368086406791,0.0863943143443837,19479590,3630576,6075819,523166,0.233583807784959,0.0435349905481935,0.0728564070102194,0.00627339211880875,414917152,30599570,37365292,9614469,1790750,99999943602.2554,2899.22666860534,387141750.418356,11.2241232035868,558306.933510737,0,0,NA,0 +"S3a",34494037,520214111.090036,83457292.8145667,104351592,20245608.2892442,14129448,0.0240307345372679,0.14177714164029,0.189041590205167,0.0894698764862355,19332282,3614629,6055063,518761,0.231642812126129,0.0433111221092604,0.0725528326620145,0.00621588578427331,414968911,30599997,37426814,9615582,1787056,104115381915.72,3018.35885187112,387255176.847052,11.2267281689021,558318.049593235,119.132183265779,0.0026049653152711,45732.7330108349,11.116082497756 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+"S3d",34501231,520389346.039061,83507083.8292405,104079260,22711873.9482136,14135933,0.0251554674459531,0.144172895875718,0.20738377463961,0.0911334097630808,19266710,3605577,6035420,519637,0.230719468535119,0.0431768999067536,0.0722743475552509,0.00622266969665208,415086795,30631737,37413709,9638221,1794998,105602366017.679,3060.82893151492,387400039.510324,11.2285860035059,558368.471243781,161.602262909575,0.00446279991906806,36210.9585552116,61.5377330438932 diff --git a/reproduction/outputs/Sen4_01_Treat_Utilsall.csv b/reproduction/outputs/Sen4_01_Treat_Utilsall.csv index b04aa16..fbcd690 100644 --- a/reproduction/outputs/Sen4_01_Treat_Utilsall.csv +++ b/reproduction/outputs/Sen4_01_Treat_Utilsall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37195779,90753454325.5885,2439.88583558335,466710528.785287,12.5474056823837,34372.2798098499,133.114292166545 -"S2a",22077788,63840415722.8595,2891.61286098315,270883900.09493,12.2695217516778,37847.2019278165,74.3289394123713 -"S1NoCD",37196486,79864892644.739,2147.10853720803,466402566.389403,12.5388878505728,NA,0 -"S2NoCD",22078563,58731887920.9201,2660.13181749736,270758372.074819,12.2634055520198,NA,0 -"S3NoCD",17243525,49933527333.6569,2895.78420500779,193546782.762299,11.2243165340207,NA,0 -"S3a",17245589,53097071420.885,3078.87839730408,193630822.054665,11.2278462657706,51871.9849740528,-6.60760479839519 -"S3b",17248093,55163743514.5954,3198.251743807,193698483.397538,11.2301390882771,51947.5689668394,-11.3398259775713 -"S1b",37200476,87878153021.8125,2362.2857143498,466602621.887519,12.5429207380981,53355.6107865744,-13.5328008807264 -"S3d",17250373,54140141633.3456,3138.49107108267,193684186.470557,11.2278259995049,69157.7868949762,-67.2335918624885 -"S3c",17249568,53820717605.7799,3120.11973898592,193662077.976417,11.2270682939084,81524.385531405,-86.7475395910442 -"S1c",37192813,88797560537.4716,2387.49245821959,466450152.720691,12.5414055860924,95476.2401140166,-114.497145032277 +"S1a",74380275,181401075128.178,2438.8330794445,933176477.052734,12.5460207972172,44083.8691435393,39.0252736047842 +"S3b",34499539,110363699543.429,3198.99055878484,387468229.642479,11.2311132517591,48264.9359699222,10.9657848943025 +"S1NoCD",74388747,159789813677.717,2148.0374400945,932792067.651946,12.5394243789581,NA,0 +"S2NoCD",44156404,117605933754.634,2663.39473102553,541539871.750723,12.2641298360873,NA,0 +"S3NoCD",34500334,99842281257.7915,2893.95115009007,387259112.683023,11.2247931478873,NA,0 +"S2a",44164773,127735308298.483,2892.24419422426,541836400.919553,12.2685200016663,52127.7521491541,-9.34118424588814 +"S1b",74383024,175747140583.673,2362.73185913594,933016458.991957,12.5434058581963,53923.2798154653,-15.6204571308335 +"S3d",34507664,108255487965.337,3137.14333040154,387489230.450196,11.2290774145186,56764.0161642444,-28.9788487460464 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a/reproduction/outputs/Sen5_0_Treat_Utilceplane.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utilceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466352936.438342,12.537361968764,0,12.537361968764,0,0,NA,NA,0 -"S1a",37195779,1,90753454325.5885,2439.88583558335,0,2439.88583558335,466511424.376262,12.542052805945,0,12.542052805945,291.045221313176,0.00469083718102326,62045.4750573303,55225.1728822385,-56.503362261923 -"S1b",37200476,1,87878153021.8125,2362.2857143498,0,2362.2857143498,466458268.887722,12.5390403307668,0,12.5390403307668,213.445100079627,0.00167836200276206,127174.649883853,94003.0870112122,-129.526999941561 -"S1c",37192813,1,88797560537.4716,2387.49245821959,0,2387.49245821959,466325355.925408,12.5380501852712,0,12.5380501852712,238.651843949422,0.000688216507210626,346768.555315084,185067.555106979,-204.241018588888 -"S2NoCD",22078563,0.593556763930821,58731887920.9201,2660.13181749736,1402.16728772077,2148.84064315472,270698654.532468,12.2607007771506,12.9413895808699,12.5373621372903,0,0,NA,NA,0.00839742925018072 -"S2a",22077788,0.593535928947491,63840415722.8595,2891.61286098315,1402.16728772077,2286.20674966379,270769119.205,12.2643228209728,12.9413895808699,12.5395261325749,137.366106509064,0.0021639952846062,63478.0063922652,63908.9571649794,-29.1579448495759 -"S3NoCD",17243525,0.463572330217334,49933527333.6569,2895.78420500779,1503.34379984433,2148.84064315472,193498381.453622,11.2215096074395,13.6745011363514,12.5373621372903,0,0,NA,NA,0.00839742925018072 -"S3a",17245589,0.463627818482614,53097071420.885,3078.87839730408,1503.34379984433,2233.80546820848,193562097.495661,11.2238612143465,13.6745011363514,12.5383162954259,84.9648250537575,0.000954158135563432,89046.9010187558,77859.1829044328,-37.2485208463622 -"S3b",17248093,0.463695135641656,55163743514.5954,3198.251743807,1503.34379984433,2289.26436882022,193591881.830173,11.2239586040134,13.6745011363514,12.5381964844232,140.4237256655,0.000834347132954605,168303.719302335,123506.721905099,-98.6979715885827 -"S3c",17249568,0.463734789319606,53820717605.7799,3120.11973898592,1503.34379984433,2253.09904935917,193574318.033416,11.2219806335681,13.6745011363514,12.5371820576911,104.258406204442,-0.000180079599150673,-578957.342731581,476269.829526865,-113.253988732817 -"S3d",17250373,0.463756430818419,54140141633.3456,3138.49107108267,1503.34379984433,2261.6538622163,193605071.924471,11.2232397481765,13.6745011363514,12.5377129039684,112.813219061578,0.000350766678103298,321618.973819273,140281.574137935,-95.2664877271745 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,932654397.95218,12.5376008350553,0,12.5376008350553,0,0,NA,NA,0 +"S1a",74380275,1,181401075128.178,2438.8330794445,0,2438.8330794445,932778303.079907,12.5406675772563,0,12.5406675772563,288.966086316825,0.00306674220103531,94225.7507720315,86022.1077367553,-135.628976265085 +"S1b",74383024,1,175747140583.673,2362.73185913594,0,2362.73185913594,932727595.687409,12.5395224008022,0,12.5395224008022,212.864866008269,0.00192156574695801,110776.780001023,96047.2856566701,-116.786578660365 +"S1c",74393892,1,177409072797.107,2384.72632668697,0,2384.72632668697,932831879.991261,12.5390923221393,0,12.5390923221393,234.859333559296,0.00149148708404034,157466.55540796,131113.558769212,-160.284979357268 +"S2NoCD",44156404,0.593591118938596,117605933754.634,2663.39473102553,1399.82062664894,2149.86699312767,541420336.358576,12.2614227453525,12.9409799661038,12.5376008350553,0,0,NA,NA,0 +"S2a",44164773,0.593703622757395,127735308298.483,2892.24419422426,1399.82062664894,2285.87790540693,541606918.406355,12.2633239483956,12.9409799661038,12.5386531334071,136.010912279254,0.00105229835182641,129251.283196622,120370.869400854,-83.3959946879186 +"S3NoCD",34500334,0.46378531781744,99842281257.7915,2893.95115009007,1506.29023425363,2149.86699312767,387162459.809839,11.2219916424531,13.6755037082683,12.5376008350553,0,0,NA,NA,0 +"S3a",34507415,0.463880507151998,106095806862.256,3074.57996671892,1506.29023425363,2233.7892707109,387293058.365321,11.2234735162086,13.6755037082683,12.5380546992237,83.9222775832291,0.000453864168402873,184906.153483205,121892.17600221,-61.2290691630915 +"S3b",34499539,0.463774630694015,110363699543.429,3198.99055878484,1506.29023425363,2291.32170213873,387254556.786523,11.2249197528849,13.6755037082683,12.5389850393757,141.454709011058,0.00138420432043773,102192.0730361,104176.196831955,-72.2444929891499 +"S3c",34496334,0.463731546127251,107627143927.157,3119.95888975209,1506.29023425363,2254.59929480501,387132897.173568,11.2224359021329,13.6755037082683,12.5379387817742,104.732301677339,0.000337946718900639,309907.733438099,508728.903183803,-87.8349657322979 +"S3d",34507664,0.463883854439712,108255487965.337,3137.14333040154,1506.29023425363,2262.81665451966,387331029.29616,11.2244928922503,13.6755037082683,12.5385193636604,112.949661391986,0.000918528605170721,122968.039053061,97228.2658790675,-67.0232311334694 diff --git a/reproduction/outputs/Sen5_0_Treat_Utilceplane_5y.csv b/reproduction/outputs/Sen5_0_Treat_Utilceplane_5y.csv index ae6c517..3147d19 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utilceplane_5y.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utilceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,79930541440.821,2148.84061427017,0,2148.84061427017,466352936.438342,12.537361968764,0,12.537361968764,0,0,NA,NA,0 -"S1a",37197502,1,87609315425.5502,2355.24728046389,0,2355.24728046389,466423278.878238,12.5391021923525,0,12.5391021923525,206.406666193722,0.00174022358851822,118609.279609567,181198.472753851,-119.395486767869 -"S1b",37190655,1,85474784067.1315,2298.28660095208,0,2298.28660095208,466341308.771155,12.5392066574561,0,12.5392066574561,149.44598668191,0.00184468869212928,81014.2043584642,119700.887159478,-57.2115520753432 -"S1c",37195162,1,86086185363.3803,2314.4457702155,0,2314.4457702155,466430965.977534,12.5400977142547,0,12.5400977142547,165.60515594533,0.00273574549069799,60533.8312750276,77113.7767195942,-28.8178814103594 -"S2NoCD",22074342,0.593443287202261,58922537504.9946,2669.27718638203,1389.16908130145,2148.84064315472,270674277.623168,12.2619409277599,12.9393893644985,12.5373621372903,0,0,NA,NA,0.00839742925018072 -"S2a",22077777,0.593535633225147,62347138313.8362,2823.97717459671,1389.16908130145,2240.77881151202,270692611.787329,12.2608635727831,12.9393893644985,12.5366601290531,91.9381683572924,-0.000702008237158935,-130964.515073742,-143592.401350707,-127.030182786053 -"S3NoCD",17254548,0.463868670889904,50064966232.8174,2901.55188260031,1497.58386473614,2148.84064315472,193618019.256424,11.2212744869598,13.6760604300141,12.5373621372903,0,0,NA,NA,0.00839742936659604 -"S3a",17251608,0.463789632372499,52066304895.3422,3018.05518044128,1497.58386473614,2202.76269727995,193617330.314547,11.2231468692395,13.6760604300141,12.5384245514209,53.9220541252316,0.00106241413062058,50754.2704592365,62221.9613525697,-0.792950164875947 -"S3b",17246874,0.463662364229167,53626126689.0333,3109.32443114232,1497.58386473614,2244.88730628008,193617261.397024,11.2262234534226,13.6760604300141,12.5401632254716,96.0466631253616,0.00280108818134472,34289.0537202768,41983.0180919463,44.0161433712346 -"S3c",17246125,0.463642228225923,52687996543.3235,3055.06289345134,1497.58386473614,2219.6969120248,193583357.374095,11.2247451166042,13.6760604300141,12.5395271360204,70.8562688700772,0.00216499873009646,32728.0879591649,44231.4584333266,37.402065064176 -"S3d",17255729,0.463900420716114,52823751958.8562,3061.22980714731,1497.58386473614,2222.95987527172,193658024.055126,11.2228248400937,13.6760604300141,12.5380034077343,74.1192321170006,0.000641270444001307,115581.862239778,102994.55076111,-42.0473124876153 +"S1NoCDAvg",74388586,1,159925565706.839,2149.86699312767,0,2149.86699312767,932654397.95218,12.5376008350553,0,12.5376008350553,0,0,NA,NA,0 +"S1a",74386318,1,175298229824.161,2356.5923752828,0,2356.5923752828,932770789.000956,12.5395477835179,0,12.5395477835179,206.725382155124,0.00194694846261179,106179.175322292,125455.612451789,-109.37795902451 +"S1b",74385413,1,170952563916.074,2298.20010431446,0,2298.20010431446,932704901.413961,12.5388145847084,0,12.5388145847084,148.33311118679,0.001213749653175,122210.631161682,162779.034763924,-87.6456285280874 +"S1c",74390720,1,171904343831.839,2310.83048842435,0,2310.83048842435,932748271.542026,12.5385030759485,0,12.5385030759485,160.963495296681,0.000902240893260853,178404.122999714,270403.20268132,-115.851450633723 +"S2NoCD",44157029,0.593599520765188,117807957834.59,2667.93216170838,1393.16700996411,2149.86699312767,541387058.854761,12.2604955794186,12.9423482587225,12.5376008350553,0,0,NA,NA,0 +"S2a",44154576,0.59356654527618,124844786046.661,2827.44841772824,1393.16700996411,2244.50847012452,541466014.087624,12.2629648643353,12.9423482587225,12.5390890043981,94.6414769968451,0.00148816934282792,63595.9055687851,64600.1824018778,-20.2330098554958 +"S3NoCD",34491937,0.463672437596811,99999943602.2554,2899.22666860534,1502.02143805571,2149.86699312767,387044338.939967,11.2212990224343,13.675586112814,12.5376008350553,0,0,NA,NA,0 +"S3a",34494037,0.46370066773416,104115381915.72,3018.35885187112,1502.02143805571,2205.14810935221,387129436.181306,11.2230828818705,13.675586112814,12.5383587270053,55.2811162245339,0.000757891950012635,72940.6298927074,66783.3915914365,-17.3865187239135 +"S3b",34509196,0.463904448997054,107308147372.611,3109.55222986393,1502.02143805571,2247.7621242753,387360806.316069,11.2248574645457,13.675586112814,12.5386821895978,97.8951311476294,0.00108135454249947,90530.0965595911,59106.0791995802,-43.8274040226825 +"S3c",34504471,0.463840931188019,105270593424.191,3050.92616618268,1502.02143805571,2220.46684947165,387285272.489227,11.2242054801891,13.675586112814,12.538535437481,70.5998563439753,0.00093460242572263,75539.9883425166,52193.9454746539,-23.869735057815 +"S3d",34501231,0.463797376118965,105602366017.679,3060.82893151492,1502.02143805571,2224.99226339667,387258904.837192,11.2244952893765,13.675586112814,12.5387766202744,75.1252702689999,0.00117578521914474,63893.701881748,50559.6891101007,-16.3360093117226 diff --git a/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults.csv b/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults.csv index 78cba28..be4d1af 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,0.400733319767278,0.0756570523768302,0.12787617648766,0.0110773590734583,0.842396438441783,0.046107470726434,0.0491632764596596,0.0110600304517264,0.00193027101638251,0.464626221589564 -"S1b",1,1,1,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,0.405990262060088,0.0763712808406,0.128937839397539,0.0111722226350007,0.842428092026923,0.0461200603625631,0.0491383508538841,0.0110450824446697,0.0019243970545918,0.334053051708208 -"S1c",1,1,1,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,0.407947954891178,0.0766530888642384,0.129489210724663,0.0112076760636524,0.842538166986253,0.0460584214654526,0.0491005034611762,0.0110279779725777,0.00192817614834111,0.288617682950729 -"S2NoCD",0.593556763930821,0.582309685946903,0.705357761730891,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535928947491,0.582469204763036,0.706205579755609,0.0223350819017627,0.146861435551105,0.229046748962462,0.0868671748983432,0.40717154949026,0.0764348498798735,0.129245718868216,0.0111517123369551,0.842521478413868,0.0460676071299697,0.0490956905759404,0.0110472695587943,0.00192542928407099,0.310401264733618 -"S3NoCD",0.463572330217334,0.415367575216711,0.586199735331415,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463627818482614,0.415521682993537,0.587418330972747,0.020135761944108,0.139262558345173,0.180514922789748,0.0822286518533507,0.41091282114974,0.0771068690707244,0.130110991228192,0.0112307468065051,0.842479359257107,0.0461006199327869,0.0491419221040822,0.0110143369803305,0.00191704201835805,0.230684563840532 -"S3b",0.463695135641656,0.415568309564907,0.587233190193687,0.022688346451263,0.146674288242097,0.23269825950894,0.087000110491251,0.406420061933482,0.0764673667010533,0.129141145874287,0.0111893784669518,0.842504903342492,0.0460727197764389,0.0491258682896983,0.011035402357133,0.00191563803310912,0.31741923502635 -"S3c",0.463734789319606,0.415536541294178,0.58767782317134,0.0213351323942394,0.142951005888522,0.207202321894185,0.0845726197929377,0.408416061307295,0.0768438830632355,0.129544969634437,0.0111987434083334,0.842454283191634,0.0461336208713429,0.049131868036605,0.0110135739715596,0.00192049474425886,0.273951977879277 -"S3d",0.463756430818419,0.415604987692288,0.587558132403041,0.0207663794232776,0.141381171887563,0.195210605479162,0.0835996238319034,0.409497721665754,0.0769666360150598,0.129714362011153,0.0112324729853736,0.842472623948323,0.0461088404884722,0.0491357216371956,0.0110219486609554,0.00191644348636688,0.254304413340487 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,0.400846084529803,0.0756315299990488,0.127733286815624,0.011087348090606,0.842364170321789,0.046129034765383,0.0491766451495284,0.011049622312511,0.00193589729339196,0.464833027470088 +"S1b",1,1,1,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,0.405907939424458,0.0764086574377509,0.129012461230401,0.0111605841676993,0.842479484739466,0.0460932357315975,0.0491198733047791,0.0110443784905514,0.00192158664025428,0.334294602837872 +"S1c",1,1,1,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,0.407967793915124,0.0766466687883462,0.129330321903309,0.0111360755262005,0.842511866298224,0.0461015049376835,0.0491018031400455,0.0110240858181335,0.00191735547661239,0.288407573923277 +"S2NoCD",0.593591118938596,0.582365621911992,0.705116455867408,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.593703622757395,0.582561633495118,0.706249983323194,0.0223572293275455,0.146520275764833,0.228783458335563,0.0867962070990575,0.406907175011621,0.0764857628938958,0.129161959754734,0.0111849702484567,0.842453436358219,0.0460995130135702,0.049162136254093,0.0110232564059888,0.00191909420686546,0.310203001792548 +"S3NoCD",0.46378531781744,0.415568056211066,0.586617239472126,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.463880507151998,0.415699320053362,0.586708781881545,0.0201156015599614,0.139591817454275,0.180822991967125,0.0824771154683174,0.410893918376555,0.0771596359153628,0.13002154727965,0.0112567726274374,0.842566021780609,0.0460728067506646,0.0490891975121309,0.0110179222026286,0.00191286787636638,0.231194614752874 +"S3b",0.463774630694015,0.415673744808273,0.587660544823951,0.022703218559012,0.147101677876022,0.233250693892965,0.0873282101842993,0.406897958993362,0.0765657243606348,0.12916424164248,0.0111938516834175,0.84245733212396,0.0460718832826625,0.0491420777172941,0.0110558113255998,0.00192827941971036,0.318156004167639 +"S3c",0.463731546127251,0.415538305063213,0.587311603486886,0.0213261904240776,0.143268049986543,0.207485881195491,0.0848645010202161,0.409017522509301,0.0768424095578439,0.12956240035588,0.0112182155362607,0.842485614704402,0.0460621493958521,0.0491521297235465,0.0110349049383035,0.00192076633511325,0.274243522611208 +"S3d",0.463883854439712,0.415752092299157,0.587221087548919,0.0207546147301295,0.141567271736428,0.195481611880112,0.0837050652172602,0.40984416843231,0.0769796311184294,0.1297896347637,0.0112424293950455,0.842510845247546,0.0460587342353947,0.0491389891816906,0.0110270863763496,0.00192123076545521,0.254532916078862 diff --git a/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults_5y.csv b/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults_5y.csv index fc6208a..2a670bd 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults_5y.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utilclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,0.403047226128249,0.0760263148853383,0.12840956363145,0.0111267149068236,0.842461254812893,0.0461118957155039,0.049118855485952,0.0110334546540076,0.00192729365384067,0.399988053390932 -"S1b",1,1,1,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,0.408631980264935,0.0767122278432579,0.129370859426918,0.0112158820542419,0.8424572166305,0.0461045345921089,0.0491178381114376,0.0110465138362427,0.00192862473289225,0.294526778968184 -"S1c",1,1,1,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,0.409231958715491,0.0769956856216946,0.129978355787239,0.0112124528453459,0.842487284544981,0.0461078639931604,0.0491352633754891,0.0110153793798817,0.00191157483979592,0.26029455677229 -"S2NoCD",0.593443287202261,0.582273174807522,0.705545677347615,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535633225147,0.582295847461883,0.706034831690326,0.0214260856128922,0.143399662052018,0.208913322432459,0.0847853184386878,0.407655221861622,0.0767470760900907,0.129218216541159,0.011199194631369,0.842544394644732,0.046094763613817,0.0491127745862289,0.0109897656237673,0.00191086601779681,0.277612135628334 -"S3NoCD",0.463868670889904,0.415635368247289,0.587073562742789,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463789632372499,0.415622940758265,0.586809647097927,0.0197696669249095,0.138028597361208,0.171429592848262,0.081236444450917,0.411287856148879,0.07722846001244,0.130038331526943,0.0112026643175846,0.842626066479021,0.0461014349785822,0.0490229859734682,0.0109954420436182,0.00190926922852537,0.216839145396673 -"S3b",0.463662364229167,0.415627753354033,0.587309552953142,0.0217273072426316,0.144075656740584,0.212315561616708,0.085323826327292,0.407654369789789,0.0766217806454282,0.129340579136661,0.0111730977587919,0.84257351681126,0.0461000010925949,0.0490636336910152,0.0110096977534996,0.00191076692651309,0.284092335789576 -"S3c",0.463642228225923,0.415569605134916,0.587621281450251,0.0206710534473348,0.140931536559447,0.191763032350927,0.08324285525963,0.409917216243935,0.07702129939584,0.12970969386912,0.0111986612734943,0.842538118936641,0.0460823834781866,0.0491061374122304,0.0110204077894173,0.00191447077751689,0.249320504213185 -"S3d",0.463900420716114,0.415712328288473,0.587409792818855,0.0202416660684579,0.139590000283801,0.18228853527996,0.0822922365025336,0.410444613492492,0.077025066408215,0.129808877075041,0.0112098048644388,0.842570046688464,0.0461323938488098,0.0490485515602565,0.0110024025072699,0.00190357830414835,0.234231338952332 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,0.403687247969445,0.076043339045226,0.128491882068958,0.0111234434267872,0.842404538075766,0.0461249975109299,0.0491350481006971,0.0110626268806794,0.00192774403765099,0.400376813672669 +"S1b",1,1,1,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,0.408261469221123,0.0767148930126932,0.12942550981064,0.0111918986051741,0.842444102006296,0.0461405534347918,0.049119839074542,0.0110326731874807,0.0019206407489528,0.294383825212184 +"S1c",1,1,1,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,0.409414400075708,0.0768280371530212,0.129676147777572,0.0111990850471672,0.842566279080345,0.0460770376386533,0.0490825292231934,0.0110175512447196,0.00191369725957158,0.260088914224771 +"S2NoCD",0.593599520765188,0.582336120728919,0.705468838282451,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.59356654527618,0.582414633463478,0.70594630719989,0.0213965559374253,0.143850474561616,0.209480412096954,0.0850850980302915,0.408667539118558,0.0767385183547775,0.129416522072223,0.0112172729297281,0.842512558981358,0.0461063547945422,0.0490973671326712,0.0110198437844154,0.00191734574481944,0.277927102442024 +"S3NoCD",0.463672437596811,0.415434005363706,0.586089346363954,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.46370066773416,0.415527713942897,0.586531096227929,0.0197899392090461,0.138303277630978,0.171711091371148,0.0814794148216474,0.412123358096292,0.0772548393515772,0.130128312756924,0.0112117859678794,0.842519910814925,0.0460735235689768,0.0491516810272371,0.0110056311963728,0.00190514377766393,0.217315925410359 +"S3b",0.463904448997054,0.415785735654782,0.587675158368244,0.0217415888048102,0.144179021361847,0.212418250542373,0.0853294076058373,0.409418571728946,0.0768062462692041,0.129433160211189,0.0111817841277405,0.842414303912108,0.0460965101654088,0.0491882510131361,0.0110409375550577,0.00191758449244497,0.28441849116625 +"S3c",0.463840931188019,0.415695058927611,0.586925015622923,0.0206753702957292,0.141063374890625,0.191706805465128,0.0833410596328628,0.410579318361524,0.076984479764633,0.129710841719411,0.0112076528740334,0.842489353520781,0.0460832909926345,0.0491418310503537,0.0110238974057143,0.0019169509018325,0.24963076915198 +"S3d",0.463797376118965,0.41566768511288,0.586881023447397,0.02025846993191,0.139712240331005,0.182490438501157,0.0824624734254074,0.411214425863804,0.0771279852307872,0.129855466070449,0.0112227977270353,0.842491682442217,0.0460936959542376,0.0491366016280874,0.011022918093246,0.00191137314896782,0.234585140125143 diff --git a/reproduction/outputs/Sen5_0_Treat_Utils1.csv b/reproduction/outputs/Sen5_0_Treat_Utils1.csv index 9a1653f..ceff1f0 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utils1.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utils1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466323093.733659,12.5367512870345,624690.455814515,0,0,NA,0 -"S1NoCD2",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466382779.143026,12.5379726318272,624748.058952971,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466352936.438342,12.537361968764,624719.257383743,0,0,NA,0 -"S1a",37195779,626218800.231142,71281372.3281143,186100281,33119194.6945306,13388772,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,14905588,2814123,4756454,412031,0.209109161526637,0.0394790799908614,0.0667278679499271,0.0057803460643741,527524487,28873365,30786968,6925999,1208772,90753454325.5885,2439.88583558335,466511424.376262,12.542052805945,624662.754461669,292.777298375314,0.00530151891058139,55225.1728822385,-27.7013528461102 -"S1b",37200476,626144171.819881,71252444.7802286,188422793,23802096.6205059,13372758,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,15103031,2841048,4796549,415612,0.211965091816623,0.0398729897446037,0.067317676113353,0.00583295073287542,527481440,28877807,30767692,6915814,1204950,87878153021.8125,2362.2857143498,466458268.887722,12.5390403307668,624589.730823989,215.177177141765,0.0022890437323202,94003.0870112122,-100.724990525749 -"S1c",37192813,625960445.075725,71159107.171146,189176712,20537776.6325788,13372239,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,15172732,2850944,4816068,416845,0.213222630288317,0.0400643587776213,0.0676802758137028,0.0058579290349644,527395566,28830750,30734973,6903078,1206962,88797560537.4716,2387.49245821959,466325355.925408,12.5380501852712,624515.016805342,240.383921011561,0.00129889823676876,185067.555106979,-175.439009173075 +"S1NoCD",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,932633078.268806,12.5372871016204,624716.317640927,0,0,NA,0 +"S1NoCD2",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,932675717.635555,12.5379145698481,624744.031938326,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,932654397.95218,12.5376008350553,624730.174789627,0,0,NA,0 +"S1a",74380275,1252107231.24309,142568770.421589,372100831,66270673.1777553,26745802,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,29815042,5625494,9500837,824680,0.209127440124749,0.0394581084157834,0.0666403797402835,0.00578443650430136,1054730269,57758498,61574433,13835312,2423951,181401075128.178,2438.8330794445,932778303.079907,12.5406675772563,624594.545783371,290.795639349996,0.00338047563586663,86022.1077367553,-121.771857556654 +"S1b",74383024,1252030977.73496,142410669.767258,376764647,47607118.2897207,26748888,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,30192660,5683507,9596337,830158,0.212011221134933,0.0399092779304288,0.0673849579928479,0.00582932445551117,1054810413,57710159,61499603,13827904,2405886,175747140583.673,2362.73185913594,932727595.687409,12.5395224008022,624613.388180975,214.694419041441,0.00223529918178933,96047.2856566701,-102.929459951934 +"S1c",74393892,1252166866.96087,142379317.946113,378416895,41063273.6656893,26758496,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,30350312,5702044,9621386,828456,0.213165173410135,0.0400482603952217,0.0675757275620708,0.00581865408509366,1054965444,57726777,61483651,13803995,2400849,177409072797.107,2384.72632668697,932831879.991261,12.5390923221393,624569.889780278,236.688886592467,0.00180522051887166,131113.558769212,-146.427860648837 diff --git a/reproduction/outputs/Sen5_0_Treat_Utils1_5y.csv b/reproduction/outputs/Sen5_0_Treat_Utils1_5y.csv index 0357899..97c9a83 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utils1_5y.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utils1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,79864892644.739,2147.10853720803,466323093.733659,12.5367512870345,624690.455814515,0,0,NA,0 -"S1NoCD",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,79996190236.903,2150.57263838883,466382779.143026,12.5379726318272,624748.058952971,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,79930541440.821,2148.84061427017,466352936.438342,12.537361968764,624719.257383743,0,0,NA,0 -"S1a",37197502,626089852.781592,71222083.952196,122776626,28487982.7184844,16327137,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,14992350,2827989,4776515,413886,0.210501422705671,0.0397066309081624,0.0670650833975313,0.00581120316948039,527456443,28870190,30752817,6907934,1206659,87609315425.5502,2355.24728046389,466423278.878238,12.5391021923525,624599.862337163,204.674642075062,0.0011295605253423,181198.472753851,-148.196615808061 -"S1b",37190655,625992698.014129,71214502.2789584,123717512,20974577.9720441,16327973,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,15197291,2852978,4811387,417126,0.213401631882082,0.0400617558039574,0.0675618988552786,0.00585731819575248,527372066,28861102,30747408,6915037,1207305,85474784067.1315,2298.28660095208,466341308.771155,12.5392066574561,624662.046271855,147.71396256325,0.00123402562895336,119700.887159478,-86.0126811155351 -"S1c",37195162,626110981.941873,71210037.1648892,124047387,18535585.0615731,16324587,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,15221449,2863867,4834566,417049,0.213754262826099,0.0402171816505112,0.0678916370848874,0.00585660416149354,527490541,28868640,30764128,6896850,1196858,86086185363.3803,2314.4457702155,466430965.977534,12.5400977142547,624690.43994252,163.87313182667,0.00212508242752207,77113.7767195942,-57.6190104505513 +"S1NoCD2",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,159789813677.717,2148.0374400945,932633078.268806,12.5372871016204,624716.317640927,0,0,NA,0 +"S1NoCD",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,160061317735.961,2151.6965540803,932675717.635555,12.5379145698481,624744.031938326,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,159925565706.839,2149.86699312767,932654397.95218,12.5376008350553,624730.174789627,0,0,NA,0 +"S1a",74386318,1252092577.05249,142511621.315835,245523949,57058348.8537602,32655914,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,30028808,5656584,9558038,827432,0.210711293035183,0.0396920893031161,0.0670684812350664,0.00580606684816418,1054768469,57752767,61521629,13851433,2413714,175298229824.161,2356.5923752828,932770789.000956,12.5395477835179,624620.796800611,204.895821202494,0.001633213669745,125455.612451789,-123.235137715121 +"S1b",74385413,1252007175.89227,142455061.307373,247448362,41936465.8685008,32651747,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,30368698,5706469,9627370,832514,0.213180898743035,0.0400580291611207,0.0675818037747859,0.0058440464828673,1054746061,57768304,61498391,13812986,2404656,170952563916.074,2298.20010431446,932704901.413961,12.5388145847084,624642.529131107,146.503550234159,0.000900014860308218,162779.034763924,-101.502807218698 +"S1c",74390720,1252048090.68724,142295860.364143,248074520,37009575.8207896,32668233,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,30456632,5715293,9646702,833108,0.214037372008291,0.0401648578207,0.0677932722379522,0.00585475921694439,1054933501,57690667,61453687,13794504,2396041,171904343831.839,2310.83048842435,932748271.542026,12.5385030759485,624614.323309002,159.133934344051,0.000588506100394071,270403.20268132,-129.708629324334 diff --git a/reproduction/outputs/Sen5_0_Treat_Utils2.csv b/reproduction/outputs/Sen5_0_Treat_Utils2.csv index 604a4c4..6e88f00 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utils2.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utils2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078563,364522748.573687,50166624.1671238,110968095,9653605.82348446,7738507,0.0172779795723912,0.141222462720366,0.158929640922804,0.0870932535738703,11438971,2125413,3543389,304919,0.228019548652357,0.0423670724368348,0.0706323987078669,0.00607812475051542,298790021,18633807,22502661,5543543,1025792,58731887920.9201,2660.13181749736,270698654.532468,12.2607007771506,610374.907040031,0,0,NA,0 -"S2a",22077788,364622606.499305,50226922.8843361,108797477,18511083.7047635,7734136,0.0229898067769556,0.157327004308664,0.269003214018226,0.0973502415391329,11192847,2087413,3500787,300763,0.22284556483333,0.041559643317329,0.0696994121670902,0.00598808333714978,298828425,18622586,22524521,5579724,1036307,63840415722.8595,2891.61286098315,270769119.205,12.2643228209728,610324.528187658,231.481043485787,0.00362204382224895,63908.9571649794,-50.3788523734547 +"S2NoCD",44156404,729084497.054691,100330759.79117,221928932,19330951.6588092,15481473,0.0172596709453046,0.141645486548806,0.159259990701265,0.08725337635747,22917076,4253860,7098458,609501,0.228415254182267,0.0423983632622146,0.070750565577046,0.00607491661847899,597619551,37246010,44990133,11123560,2050468,117605933754.634,2663.39473102553,541420336.358576,12.2614227453525,610407.742536601,0,0,NA,0 +"S2a",44164773,729329891.015329,100492048.993736,217625447,37010683.2532179,15485858,0.0230145995823502,0.157180410449991,0.268827891528291,0.0973046709934024,22383331,4181008,7006346,603148,0.222737333193348,0.0416053612386849,0.0697204014661571,0.00600194747783078,597700094,37284225,45068617,11147317,2064302,127735308298.483,2892.24419422426,541606918.406355,12.2633239483956,610273.953225555,228.84946319874,0.00190120304304386,120370.869400854,-133.789311046479 diff --git a/reproduction/outputs/Sen5_0_Treat_Utils2_5y.csv b/reproduction/outputs/Sen5_0_Treat_Utils2_5y.csv index bd85c73..bfe775d 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utils2_5y.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utils2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22074342,364499892.795735,50179989.1467565,72492409,9769650.24862608,9434235,0.0208917555301636,0.141988942022567,0.159733364688847,0.0874666663868567,11472370,2126666,3551252,304704,0.228624401779918,0.0423807584688858,0.070770282345299,0.00607222132130921,298757005,18626945,22501053,5562438,1027303,58922537504.9946,2669.27718638203,270674277.623168,12.2619409277599,610427.769201611,0,0,NA,0 -"S2a",22077777,364514085.756087,50214778.8994209,71673455,16290550.2537317,9435494,0.0250429167756047,0.153202361136407,0.241328632393267,0.094789501013715,11245330,2100490,3507989,302346,0.223944628383691,0.0418301154767053,0.0698596922437202,0.00602105608401846,298734836,18629376,22530917,5562183,1028646,62347138313.8362,2823.97717459671,270692611.787329,12.2608635727831,610219.20146456,154.699988214681,-0.00107735497672223,-143592.401350707,-208.56773705082 +"S2NoCD",44157029,729047563.461063,100380900.154714,145000421,19524492.074223,18863743,0.0209029627109113,0.141781753914197,0.159519185673724,0.0873704363140082,22925265,4254784,7099566,609563,0.228382739790797,0.0423863901742486,0.0707262635527043,0.00607249983871931,597538799,37245010,45040554,11117169,2054803,117807957834.59,2667.93216170838,541387058.854761,12.2604955794186,610356.846809224,0,0,NA,0 +"S2a",44154576,729145856.381239,100448839.030434,143361789,32595478.4145126,18878233,0.0250078581664384,0.153560443203067,0.241814960491553,0.0950258179639202,22519648,4200194,7025459,605531,0.224190226759883,0.0418142612751096,0.0699406689794734,0.00602825284836329,597564735,37286040,45033303,11135908,2066352,124844786046.661,2827.44841772824,541466014.087624,12.2629648643353,610320.794799038,159.516256019854,0.00246928491668186,64600.1824018778,-36.0520101857837 diff --git a/reproduction/outputs/Sen5_0_Treat_Utils3.csv b/reproduction/outputs/Sen5_0_Treat_Utils3.csv index 31da2d8..11a4e82 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utils3.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utils3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17243525,260017880.24558,41691838.3900313,80059027,7819384.14256,5815322,0.0183575174217772,0.137156256672018,0.154366597029931,0.0863650846874626,9754415,1816466,3038101,261338,0.233964616977224,0.043568863119126,0.0728704014339272,0.00626832517086814,207433146,15294590,18682841,4808648,895345,49933527333.6569,2895.78420500779,193498381.453622,11.2215096074395,558179.696166965,0,0,NA,0 -"S3a",17245589,260114350.889536,41778507.6419587,79305268,11012874.3912697,5816924,0.0210701415875502,0.143601112787989,0.204102307078173,0.090802566674972,9648241,1803612,3027939,260144,0.230937904309204,0.0431708096291264,0.0724759971310943,0.00622674228168777,207442211,15303706,18733677,4824249,900624,53097071420.885,3078.87839730408,193562097.495661,11.2238612143465,558114.182320022,183.094192296297,0.00235160690706238,77859.1829044328,-65.5138469431549 -"S3b",17248093,260143538.873804,41765340.0149969,77789956,17179218.0534133,5809490,0.0272123567386269,0.156225870536493,0.292983388954392,0.0989344402695251,9481831,1779958,2992091,258625,0.227026309293671,0.0426180655864614,0.0716405277420372,0.00619233555639998,207483725,15287322,18724587,4837601,899769,55163743514.5954,3198.251743807,193591881.830173,11.2239586040134,557999.678456861,302.467538799216,0.00244899657390008,123506.721905099,-180.017710104119 -"S3c",17249568,260123652.106259,41796963.3084409,78552778,14093542.3037528,5811921,0.0239564020668036,0.149872778444183,0.249488678363603,0.0947819160826065,9556493,1794042,3007246,258985,0.228640844778072,0.0429227833314315,0.0719489111639047,0.00619626354404789,207434647,15324709,18727689,4823824,902793,53820717605.7799,3120.11973898592,193574318.033416,11.2219806335681,557978.911939418,224.335533978136,0.000471026128614938,476269.829526865,-200.784227547236 -"S3d",17250373,260166499.185349,41788450.6328664,78909896,12694598.7095123,5812281,0.0225871693478081,0.14720440466007,0.229100157335109,0.0931309605323503,9596955,1798651,3013620,260246,0.229655678893537,0.0430418207126676,0.0721160979734865,0.00622770157923294,207483596,15310784,18731510,4829309,900292,54140141633.3456,3138.49107108267,193605071.924471,11.2232397481765,558023.496337743,242.706866074884,0.00173014073705957,140281.574137935,-156.19982922182 +"S3NoCD",34500334,520264617.028559,83469550.1049324,160191877,15617539.1621454,11630123,0.018371612334161,0.136660912007116,0.153889981724535,0.0860423303941354,19525292,3631989,6073558,522424,0.23392113621619,0.0435127420171081,0.0727637562723739,0.00625885726403513,415002016,30608834,37422882,9624470,1788687,99842281257.7915,2893.95115009007,387162459.809839,11.2219916424531,558205.630972563,0,0,NA,0 +"S3a",34507415,520428950.960441,83482575.6405212,158676520,22030097.8695766,11639538,0.0210425232718254,0.143591703407669,0.204088019848658,0.0908272943093332,19287934,3609226,6045313,521405,0.231041434119792,0.043233285177274,0.072414069087079,0.00624567457340066,415152628,30610103,37407716,9641236,1794702,106095806862.256,3074.57996671892,387293058.365321,11.2234735162086,558099.095843713,180.628816628857,0.00148187375558528,121892.17600221,-106.535128849675 +"S3b",34499539,520396932.389974,83618001.6376853,155590263,34428826.1327912,11625591,0.0272677362023387,0.156355277894248,0.293211112522871,0.0990494988470827,18988453,3564625,5980823,516662,0.227085706762959,0.0426298755074946,0.0715255433383203,0.00617883697147755,414988556,30607762,37472866,9688489,1813970,110363699543.429,3198.99055878484,387254556.786523,11.2249197528849,558046.997085461,305.03940869477,0.00292811043185637,104176.196831955,-158.633887102013 +"S3c",34496334,520227370.495019,83568350.903854,157099275,28171360.7955484,11622564,0.0239564406652199,0.14984119401007,0.249428440470547,0.0948714951513754,19145218,3585036,6010150,518449,0.229096515522087,0.0428994465156386,0.0719189733313599,0.00620389171728995,414875686,30589301,37479876,9661353,1804425,107627143927.157,3119.95888975209,387132897.173568,11.2224359021329,558001.836216894,226.007739662019,0.000444259679856174,508728.903183803,-203.794755669194 +"S3d",34507664,520495018.435642,83555471.4245087,157877292,25364365.9811382,11630839,0.0225793272116635,0.14694733242596,0.229001602594022,0.0929007877476101,19209915,3595849,6028084,520340,0.229906129095997,0.0430354701935804,0.0721446949820192,0.00622747967462694,415141325,30594930,37472224,9653084,1805226,108255487965.337,3137.14333040154,387331029.29616,11.2244928922503,558087.501282111,243.192180311468,0.00250124979719324,97228.2658790675,-118.12969045178 diff --git a/reproduction/outputs/Sen5_0_Treat_Utils3_5y.csv b/reproduction/outputs/Sen5_0_Treat_Utils3_5y.csv index 84ae927..0b1b1d0 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utils3_5y.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utils3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17254548,260185517.250271,41753986.9530892,52456874,7922835.39457538,7061036,0.0221592886073816,0.13726133321656,0.154573171523665,0.0864947424330528,9767617,1818208,3040076,262205,0.233932558607492,0.043545733777298,0.0728092386342779,0.00627975959025394,207533583,15301679,18724752,4815426,897482,50064966232.8174,2901.55188260031,193618019.256424,11.2212744869598,558162.172465392,0,0,NA,0 -"S3a",17251608,260177737.708618,41735216.681199,52193377,10112285.5219638,7056308,0.0239901655742498,0.141620447019917,0.188896901320193,0.0892874240346538,9673981,1809610,3026757,259927,0.23179419610772,0.0433593052558704,0.0725228533763311,0.00622800168944835,207543323,15307443,18697708,4818609,897810,52066304895.3422,3018.05518044128,193617330.314547,11.2231468692395,558139.288281533,116.503297840971,0.0018723822796396,62221.9613525697,-22.8841838589869 -"S3b",17246874,260180750.367826,41770771.1055183,51592135,14901907.2426103,7060341,0.0287001627876402,0.151909252445312,0.258476623670136,0.0962303406481393,9537491,1786791,3000373,258790,0.228329301748035,0.0427761076156898,0.0718294855611038,0.00619548055137079,207513062,15306657,18723252,4827550,898750,53626126689.0333,3109.32443114232,193617261.397024,11.2262234534226,558201.848239987,207.772548542013,0.00494896646274867,41983.0180919463,39.675774595351 -"S3c",17246125,260144349.893699,41792941.9345714,51894923,12432862.6252413,7060467,0.0261601311174318,0.146548593395628,0.223441477763239,0.0926749735395,9621451,1801612,3014035,259735,0.23021712649621,0.0431080444832167,0.0721182778833468,0.00621480537088358,207459068,15294280,18748666,4834049,901039,52687996543.3235,3055.06289345134,193583357.374095,11.2247451166042,558182.192936758,153.511010851031,0.00347062964433853,44231.4584333266,20.0204713658895 -"S3d",17255729,260233693.824386,41777900.3893267,52047317,11356969.6042882,7062160,0.0251240111093077,0.14426968081771,0.207339855216131,0.0910648854849654,9643777,1802264,3018596,260225,0.23083441030138,0.0431391712653046,0.0722534156065723,0.00622877161310102,207557193,15328896,18715546,4823282,894293,52823751958.8562,3061.22980714731,193658024.055126,11.2228248400937,558080.01219754,159.677924547001,0.00155035313389895,102994.55076111,-82.1602678521303 +"S3NoCD",34491937,520096793.944658,83394436.3897572,104866546,15798843.6062051,14116443,0.0221440059305719,0.13704346682043,0.154368086406791,0.0863943143443837,19479590,3630576,6075819,523166,0.233583807784959,0.0435349905481935,0.0728564070102194,0.00627339211880875,414917152,30599570,37365292,9614469,1790750,99999943602.2554,2899.22666860534,387044338.939967,11.2212990224343,558165.724453112,0,0,NA,0 +"S3a",34494037,520214111.090036,83457292.8145667,104351592,20245608.2892442,14129448,0.0240307345372679,0.14177714164029,0.189041590205167,0.0894698764862355,19332282,3614629,6055063,518761,0.231642812126129,0.0433111221092604,0.0725528326620145,0.00621588578427331,414968911,30599997,37426814,9615582,1787056,104115381915.72,3018.35885187112,387129436.181306,11.2230828818705,558135.785241652,119.132183265779,0.00178385943610948,66783.3915914365,-29.9392114602961 +"S3b",34509196,520537137.764278,83620080.9934994,103218767,29823148.4264926,14132996,0.0287201148667908,0.151759070463881,0.258228121857447,0.0959834805484866,19135380,3582069,6004729,516649,0.228837137834004,0.0428374256212269,0.0718096530002979,0.00617852785911753,415119150,30640730,37483240,9661621,1802895,107308147372.611,3109.55222986393,387360806.316069,11.2248574645457,558133.320997419,210.325561258588,0.0035584421113164,59106.0791995802,-32.4034556926927 +"S3c",34504471,520423616.303641,83513343.4596301,103824096,24853846.8628113,14121585,0.0261578150769642,0.14647414308412,0.223082059564315,0.0926287674905986,19220385,3595075,6024956,518536,0.23014747349076,0.0430479112806427,0.0721436329861758,0.00620901976281979,415113845,30619979,37421385,9639642,1802009,105270593424.191,3050.92616618268,387285272.489227,11.2242054801891,558159.347843274,151.699497577334,0.00290645775477927,52193.9454746539,-6.37660983845126 +"S3d",34501231,520389346.039061,83507083.8292405,104079260,22711873.9482136,14135933,0.0251554674459531,0.144172895875718,0.20738377463961,0.0911334097630808,19266710,3605577,6035420,519637,0.230719468535119,0.0431768999067536,0.0722743475552509,0.00622266969665208,415086795,30631737,37413709,9638221,1794998,105602366017.679,3060.82893151492,387258904.837192,11.2244952893765,558163.935537312,161.602262909575,0.00319626694218123,50559.6891101007,-1.78891580039635 diff --git a/reproduction/outputs/Sen5_0_Treat_Utilsall.csv b/reproduction/outputs/Sen5_0_Treat_Utilsall.csv index 87fb525..ad319da 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utilsall.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utilsall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1NoCD",37196486,79864892644.739,2147.10853720803,466323093.733659,12.5367512870345,NA,0 -"S2NoCD",22078563,58731887920.9201,2660.13181749736,270698654.532468,12.2607007771506,NA,0 -"S3NoCD",17243525,49933527333.6569,2895.78420500779,193498381.453622,11.2215096074395,NA,0 -"S1a",37195779,90753454325.5885,2439.88583558335,466511424.376262,12.542052805945,55225.1728822385,-27.7013528461102 -"S2a",22077788,63840415722.8595,2891.61286098315,270769119.205,12.2643228209728,63908.9571649794,-50.3788523734547 -"S3a",17245589,53097071420.885,3078.87839730408,193562097.495661,11.2238612143465,77859.1829044328,-65.5138469431549 -"S1b",37200476,87878153021.8125,2362.2857143498,466458268.887722,12.5390403307668,94003.0870112122,-100.724990525749 -"S3d",17250373,54140141633.3456,3138.49107108267,193605071.924471,11.2232397481765,140281.574137935,-156.19982922182 -"S1c",37192813,88797560537.4716,2387.49245821959,466325355.925408,12.5380501852712,185067.555106979,-175.439009173075 -"S3b",17248093,55163743514.5954,3198.251743807,193591881.830173,11.2239586040134,123506.721905099,-180.017710104119 -"S3c",17249568,53820717605.7799,3120.11973898592,193574318.033416,11.2219806335681,476269.829526865,-200.784227547236 +"S1NoCD",74388747,159789813677.717,2148.0374400945,932633078.268806,12.5372871016204,NA,0 +"S2NoCD",44156404,117605933754.634,2663.39473102553,541420336.358576,12.2614227453525,NA,0 +"S3NoCD",34500334,99842281257.7915,2893.95115009007,387162459.809839,11.2219916424531,NA,0 +"S1b",74383024,175747140583.673,2362.73185913594,932727595.687409,12.5395224008022,96047.2856566701,-102.929459951934 +"S3a",34507415,106095806862.256,3074.57996671892,387293058.365321,11.2234735162086,121892.17600221,-106.535128849675 +"S3d",34507664,108255487965.337,3137.14333040154,387331029.29616,11.2244928922503,97228.2658790675,-118.12969045178 +"S1a",74380275,181401075128.178,2438.8330794445,932778303.079907,12.5406675772563,86022.1077367553,-121.771857556654 +"S2a",44164773,127735308298.483,2892.24419422426,541606918.406355,12.2633239483956,120370.869400854,-133.789311046479 +"S1c",74393892,177409072797.107,2384.72632668697,932831879.991261,12.5390923221393,131113.558769212,-146.427860648837 +"S3b",34499539,110363699543.429,3198.99055878484,387254556.786523,11.2249197528849,104176.196831955,-158.633887102013 +"S3c",34496334,107627143927.157,3119.95888975209,387132897.173568,11.2224359021329,508728.903183803,-203.794755669194 diff --git a/reproduction/outputs/Sen5_0_Treat_Utilsall_5y.csv b/reproduction/outputs/Sen5_0_Treat_Utilsall_5y.csv index f2f887e..514e5bf 100644 --- a/reproduction/outputs/Sen5_0_Treat_Utilsall_5y.csv +++ b/reproduction/outputs/Sen5_0_Treat_Utilsall_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S3b",17246874,53626126689.0333,3109.32443114232,193617261.397024,11.2262234534226,41983.0180919463,39.675774595351 -"S3c",17246125,52687996543.3235,3055.06289345134,193583357.374095,11.2247451166042,44231.4584333266,20.0204713658895 -"S1NoCD",37197623,79996190236.903,2150.57263838883,466382779.143026,12.5379726318272,NA,0 -"S2NoCD",22074342,58922537504.9946,2669.27718638203,270674277.623168,12.2619409277599,NA,0 -"S3NoCD",17254548,50064966232.8174,2901.55188260031,193618019.256424,11.2212744869598,NA,0 -"S3a",17251608,52066304895.3422,3018.05518044128,193617330.314547,11.2231468692395,62221.9613525697,-22.8841838589869 -"S1c",37195162,86086185363.3803,2314.4457702155,466430965.977534,12.5400977142547,77113.7767195942,-57.6190104505513 -"S3d",17255729,52823751958.8562,3061.22980714731,193658024.055126,11.2228248400937,102994.55076111,-82.1602678521303 -"S1b",37190655,85474784067.1315,2298.28660095208,466341308.771155,12.5392066574561,119700.887159478,-86.0126811155351 -"S1a",37197502,87609315425.5502,2355.24728046389,466423278.878238,12.5391021923525,181198.472753851,-148.196615808061 -"S2a",22077777,62347138313.8362,2823.97717459671,270692611.787329,12.2608635727831,-143592.401350707,-208.56773705082 +"S1NoCD",74388425,160061317735.961,2151.6965540803,932675717.635555,12.5379145698481,NA,0 +"S2NoCD",44157029,117807957834.59,2667.93216170838,541387058.854761,12.2604955794186,NA,0 +"S3NoCD",34491937,99999943602.2554,2899.22666860534,387044338.939967,11.2212990224343,NA,0 +"S3d",34501231,105602366017.679,3060.82893151492,387258904.837192,11.2244952893765,50559.6891101007,-1.78891580039635 +"S3c",34504471,105270593424.191,3050.92616618268,387285272.489227,11.2242054801891,52193.9454746539,-6.37660983845126 +"S3a",34494037,104115381915.72,3018.35885187112,387129436.181306,11.2230828818705,66783.3915914365,-29.9392114602961 +"S3b",34509196,107308147372.611,3109.55222986393,387360806.316069,11.2248574645457,59106.0791995802,-32.4034556926927 +"S2a",44154576,124844786046.661,2827.44841772824,541466014.087624,12.2629648643353,64600.1824018778,-36.0520101857837 +"S1b",74385413,170952563916.074,2298.20010431446,932704901.413961,12.5388145847084,162779.034763924,-101.502807218698 +"S1a",74386318,175298229824.161,2356.5923752828,932770789.000956,12.5395477835179,125455.612451789,-123.235137715121 +"S1c",74390720,171904343831.839,2310.83048842435,932748271.542026,12.5385030759485,270403.20268132,-129.708629324334 diff --git a/reproduction/outputs/Sen6_0_Discount_CEplot-1.png b/reproduction/outputs/Sen6_0_Discount_CEplot-1.png index 848fe10..49a180c 100644 Binary files a/reproduction/outputs/Sen6_0_Discount_CEplot-1.png and b/reproduction/outputs/Sen6_0_Discount_CEplot-1.png differ diff --git a/reproduction/outputs/Sen6_0_Discount_CEplot_5y-1.png b/reproduction/outputs/Sen6_0_Discount_CEplot_5y-1.png index b951921..71fd557 100644 Binary files a/reproduction/outputs/Sen6_0_Discount_CEplot_5y-1.png and b/reproduction/outputs/Sen6_0_Discount_CEplot_5y-1.png differ diff --git a/reproduction/outputs/Sen6_0_Discountceplane.csv b/reproduction/outputs/Sen6_0_Discountceplane.csv index 978d711..9851bf2 100644 --- a/reproduction/outputs/Sen6_0_Discountceplane.csv +++ b/reproduction/outputs/Sen6_0_Discountceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,92902829112.159,2497.58563845852,0,2497.58563845852,529963816.816132,14.247467277715,0,14.247467277715,0,0,NA,NA,0 -"S1a",37195779,1,105211197488.536,2828.57894946994,0,2828.57894946994,530667768.51192,14.2668814252262,0,14.2668814252262,330.993311011421,0.0194141475112133,17049.0777831087,16519.7451075161,639.714064549189 -"S1b",37200476,1,101909010383.134,2739.45447319368,0,2739.45447319368,530366539.389009,14.2569826092819,0,14.2569826092819,241.868834735153,0.00951533156687745,25418.8551429033,23772.8084339458,233.897743608686 -"S1c",37192813,1,102900329677.61,2766.67241269463,0,2766.67241269463,530129569.91612,14.2535486604931,0,14.2535486604931,269.086774236103,0.00608138277808301,44247.6298656743,39724.2728141054,34.9823646679288 -"S2NoCD",22078563,0.593556763930821,67978101358.6265,3078.91873935031,1648.62536568845,2497.58567203088,307350490.064811,13.9207651360648,14.7245731568925,14.2474674692284,0,0,NA,NA,0.00954209663905203 -"S2a",22077788,0.593535928947491,73774185782.3801,3341.55694322185,1648.62536568845,2653.44108220428,307671897.941364,13.9358117734151,14.7245731568925,14.2564149364324,155.855410173398,0.00894746720397599,17418.9417653456,17454.943437303,291.527492122143 -"S3NoCD",17243525,0.463572330217334,57710008551.5133,3346.76399120907,1763.73916416718,2497.58567203088,218436256.441118,12.6677263750375,15.6126548028178,14.2474674692284,0,0,NA,NA,0.00954209663905203 -"S3a",17245589,0.463627818482614,61268007224.7443,3552.67699031586,1763.73916416718,2593.14050590552,218598437.880415,12.6756144936781,15.6126548028178,14.2509612114958,95.5548338746426,0.0034937422674215,27350.281320312,26104.1965124738,79.1418215930462 -"S3b",17248093,0.463695135641656,63624999198.9553,3688.81355167527,1763.73916416718,2656.38679340302,218793326.615176,12.6850734521883,15.6126548028178,14.2551495713357,158.801121372141,0.00768210210727993,20671.5712905785,19717.9938436719,225.313526088488 -"S3c",17249568,0.463734789319606,62103127614.4747,3600.27147430444,1763.73916416718,2615.40308808733,218692117.107242,12.6781213945325,15.6126548028178,14.2518095709752,117.817416056453,0.00434210174683614,27133.7299136991,24387.3985246826,99.2972133819712 -"S3d",17250373,0.463756430818419,62445799073.8093,3619.96804786826,1763.73916416718,2624.57724605445,218689857.965539,12.6773987997557,15.6126548028178,14.2514109552994,126.99157402357,0.00394348607098927,32202.8712001289,28245.6637934493,70.1922716225963 +"S1NoCDAvg",74388586,1,185878883056.643,2498.75542810618,0,2498.75542810618,1059872894.53029,14.2477892311368,0,14.2477892311368,0,0,NA,NA,0 +"S1a",74380275,1,210298062988.674,2827.33645430423,0,2827.33645430423,1061052827.37569,14.2652447490371,0,14.2652447490371,328.58102619805,0.0174555179003164,18823.9058889278,18518.3920466481,544.194868817693 +"S1b",74383024,1,203807677144.238,2739.97568510038,0,2739.97568510038,1060522850.47389,14.2575925721155,0,14.2575925721155,241.220256994198,0.0098033409787508,24605.9233803103,23844.4463327645,248.946791943279 +"S1c",74393892,1,205585395445.529,2763.47143453026,0,2763.47143453026,1060470315.25251,14.2548035429107,0,14.2548035429107,264.716006424079,0.00701431177388478,37739.4126405462,35982.4230321943,85.9995822701603 +"S2NoCD",44156404,0.593591118938596,136124332102.838,3082.77667046524,1645.74793026205,2498.75542810618,614729143.469625,13.9216305627973,14.7241688033192,14.2477892311368,0,0,NA,NA,-1.16415321826935e-10 +"S2a",44164773,0.593703622757395,147612114723.849,3342.30439096446,1645.74793026205,2652.99964719353,615416265.999239,13.9345506428673,14.7241688033192,14.2553696408639,154.244219087353,0.00758040972709395,20347.7416973983,20087.1603808086,224.776267267182 +"S3NoCD",34500334,0.46378531781744,115393106843.54,3344.69535406642,1767.08109979609,2498.75542810618,437057823.162521,12.668220057305,15.6139976093154,14.2477892311368,0,0,NA,NA,-1.16415321826935e-10 +"S3a",34507415,0.463880507151998,122423689898.09,3547.7502414507,1767.08109979609,2593.09880429674,437381358.392527,12.6749963273843,15.6139976093154,14.2506522041329,94.3433761905635,0.00286297299607696,32952.9395910612,29965.5835742348,48.805273613194 +"S3b",34499539,0.463774630694015,127296658688.636,3689.80752724366,1767.08109979609,2658.79283861121,437670760.97409,12.6862785318404,15.6139976093154,14.2561957753836,160.037410505029,0.00840654424682441,19037.2412023506,19110.8153959055,260.28980183613 +"S3c",34496334,0.463731546127251,124195481660.429,3600.25159950123,1767.08109979609,2617.18008993922,437363545.965671,12.6785514647925,15.6139976093154,14.2527386301425,118.42466183304,0.00494939900573854,23927.0791657196,24735.8596342475,129.045288453694 +"S3d",34507664,0.463883854439712,124862452608.862,3618.39771619609,1767.08109979609,2625.87698760001,437518341.968706,12.6788745238943,15.6139976093154,14.2524413991953,127.121559493825,0.0046521680585343,27325.2294187059,25688.9784048922,105.486843432765 diff --git a/reproduction/outputs/Sen6_0_Discountceplane_5y.csv b/reproduction/outputs/Sen6_0_Discountceplane_5y.csv index 90cf2af..735556a 100644 --- a/reproduction/outputs/Sen6_0_Discountceplane_5y.csv +++ b/reproduction/outputs/Sen6_0_Discountceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,92902829112.159,2497.58563845852,0,2497.58563845852,529963816.816132,14.247467277715,0,14.247467277715,0,0,NA,NA,0 -"S1a",37197502,1,101593628148.474,2731.19491057422,0,2731.19491057422,530443726.842454,14.2601975488153,0,14.2601975488153,233.609272115697,0.0127302711003274,18350.6910634203,19321.3408439935,402.904282900621 -"S1b",37190655,1,99147551250.5217,2665.92646057247,0,2665.92646057247,530160005.562289,14.25519409546,0,14.25519409546,168.340822113943,0.00772681774494544,21786.5656562256,23817.8907300768,218.000065133208 -"S1c",37195162,1,99801217926.1646,2683.17739619375,0,2683.17739619375,530199954.883661,14.2545408159174,0,14.2545408159174,185.591757735224,0.00707353820241785,26237.4716053397,29000.466644741,168.08515238564 -"S2NoCD",22074342,0.593443287202261,68198452610.1151,3089.48971661829,1633.59432501551,2497.58567203088,307327847.064593,13.9224012686128,14.7219605684178,14.2474674692284,0,0,NA,NA,0.00954209663905203 -"S2a",22077777,0.593535633225147,72055390303.5079,3263.70677190497,1633.59432501551,2601.12414840824,307521349.116734,13.9289996957907,14.7219605684178,14.2513100347603,103.538476377359,0.00384256553190099,26945.1426443563,26402.8154878035,88.5993423145264 -"S3NoCD",17254548,0.463868670889904,57864310923.5952,3353.56863150488,1756.97669031985,2497.58567203088,218572819.44283,12.6675482570062,15.6144366898173,14.2474674692284,0,0,NA,NA,0.00954209663905203 -"S3a",17251608,0.463789632372499,60089152167.6302,3483.1044252588,1756.97669031985,2557.53683793516,218633446.064064,12.673221305751,15.6144366898173,14.2503314881129,59.9511659042805,0.00286401888446441,20932.5316356954,22833.5414662006,83.2593204156728 -"S3b",17246874,0.463662364229167,61869748507.0021,3587.30216890331,1756.97669031985,2605.62972902874,218763932.889481,12.6842657335747,15.6144366898173,14.2558266966502,108.044056997856,0.00835922742183648,12925.1247209302,13981.3886647681,309.926856190665 -"S3c",17246125,0.463642228225923,60807623937.5119,3525.87169219241,1756.97669031985,2577.11111048574,218659411.906197,12.6787560629531,15.6144366898173,14.2533311826183,79.5254384548625,0.00586371338991931,13562.2997180558,15373.4871485144,213.669773137779 -"S3d",17255729,0.463900420716114,60941413667.9918,3531.66265348696,1756.97669031985,2580.25425527205,218712958.12271,12.674802561092,15.6144366898173,14.2507391807502,82.6685832411708,0.00327171152181194,25267.6871692488,24550.1180919973,80.9265349460766 +"S1NoCDAvg",74388586,1,185878883056.643,2498.75542810618,0,2498.75542810618,1059872894.53029,14.2477892311368,0,14.2477892311368,0,0,NA,NA,0 +"S1a",74386318,1,203290806711.172,2732.90589152661,0,2732.90589152661,1060803037.08176,14.2607278543046,0,14.2607278543046,234.150463420425,0.0129386231677966,18097.0154539481,18508.8925540807,412.780694969348 +"S1b",74385413,1,198298896719.68,2665.83041919361,0,2665.83041919361,1060342608.87995,14.2547115908323,0,14.2547115908323,167.074991087432,0.00692235969553145,24135.5547004127,25298.0112796287,179.042993689072 +"S1c",74390720,1,199278771241.365,2678.81223950198,0,2678.81223950198,1060261851.16163,14.2526090776057,0,14.2526090776057,180.056811395802,0.00481984646894951,37357.3748781764,40270.480397409,60.9355120515684 +"S2NoCD",44157029,0.593599520765188,136358873736.606,3088.04457239652,1638.02378157492,2498.75542810618,614694012.163514,13.9206379161858,14.7256352812651,14.2477892311368,0,0,NA,NA,0 +"S2a",44154576,0.59356654527618,144286219339.485,3267.75234665339,1638.02378157492,2605.37613568645,615140303.22925,13.9315187451749,14.7256352812651,14.2542742723914,106.620707580272,0.00648504125459404,16441.0222532881,16516.0002455766,217.631355149439 +"S3NoCD",34491937,0.463672437596811,115570166575.01,3350.64297998138,1762.27122437359,2498.75542810618,436927836.474174,12.6675355018239,15.6139694352806,14.2477892311368,0,0,NA,NA,-1.16415321826935e-10 +"S3a",34494037,0.46370066773416,120160874412.554,3483.52599066771,1762.27122437359,2560.41820884478,437149997.768731,12.6732048721561,15.6139694352806,14.2503349437108,61.6627807386003,0.00254571257401537,24222.2084959651,23438.7600212088,65.6228479620768 +"S3b",34509196,0.463904448997054,123796077466.842,3587.33589350625,1762.27122437359,2608.92684409157,437667748.693372,12.6826411340725,15.6139694352806,14.2541131948792,110.171415985386,0.00632396374242461,17421.2599048119,15669.1828338689,206.026771135628 +"S3c",34504471,0.463840931188019,121485915693.67,3520.8746047337,1762.27122437359,2577.98345391022,437449142.201033,12.6780422804057,15.6139694352806,14.2521662498633,79.2280258040405,0.00437701872646912,18100.910860839,16202.0759671373,139.622910519247 +"S3d",34501231,0.463797376118965,121822210447.546,3530.95257521525,1762.27122437359,2582.5809940845,437363184.796397,12.6767414413821,15.6139694352806,14.2516907986473,83.8255659783158,0.00390156751052473,21485.0994509748,19586.224099597,111.252809547819 diff --git a/reproduction/outputs/Sen6_0_Discountclinicalresults.csv b/reproduction/outputs/Sen6_0_Discountclinicalresults.csv index 78cba28..be4d1af 100644 --- a/reproduction/outputs/Sen6_0_Discountclinicalresults.csv +++ b/reproduction/outputs/Sen6_0_Discountclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,0.400733319767278,0.0756570523768302,0.12787617648766,0.0110773590734583,0.842396438441783,0.046107470726434,0.0491632764596596,0.0110600304517264,0.00193027101638251,0.464626221589564 -"S1b",1,1,1,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,0.405990262060088,0.0763712808406,0.128937839397539,0.0111722226350007,0.842428092026923,0.0461200603625631,0.0491383508538841,0.0110450824446697,0.0019243970545918,0.334053051708208 -"S1c",1,1,1,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,0.407947954891178,0.0766530888642384,0.129489210724663,0.0112076760636524,0.842538166986253,0.0460584214654526,0.0491005034611762,0.0110279779725777,0.00192817614834111,0.288617682950729 -"S2NoCD",0.593556763930821,0.582309685946903,0.705357761730891,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535928947491,0.582469204763036,0.706205579755609,0.0223350819017627,0.146861435551105,0.229046748962462,0.0868671748983432,0.40717154949026,0.0764348498798735,0.129245718868216,0.0111517123369551,0.842521478413868,0.0460676071299697,0.0490956905759404,0.0110472695587943,0.00192542928407099,0.310401264733618 -"S3NoCD",0.463572330217334,0.415367575216711,0.586199735331415,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463627818482614,0.415521682993537,0.587418330972747,0.020135761944108,0.139262558345173,0.180514922789748,0.0822286518533507,0.41091282114974,0.0771068690707244,0.130110991228192,0.0112307468065051,0.842479359257107,0.0461006199327869,0.0491419221040822,0.0110143369803305,0.00191704201835805,0.230684563840532 -"S3b",0.463695135641656,0.415568309564907,0.587233190193687,0.022688346451263,0.146674288242097,0.23269825950894,0.087000110491251,0.406420061933482,0.0764673667010533,0.129141145874287,0.0111893784669518,0.842504903342492,0.0460727197764389,0.0491258682896983,0.011035402357133,0.00191563803310912,0.31741923502635 -"S3c",0.463734789319606,0.415536541294178,0.58767782317134,0.0213351323942394,0.142951005888522,0.207202321894185,0.0845726197929377,0.408416061307295,0.0768438830632355,0.129544969634437,0.0111987434083334,0.842454283191634,0.0461336208713429,0.049131868036605,0.0110135739715596,0.00192049474425886,0.273951977879277 -"S3d",0.463756430818419,0.415604987692288,0.587558132403041,0.0207663794232776,0.141381171887563,0.195210605479162,0.0835996238319034,0.409497721665754,0.0769666360150598,0.129714362011153,0.0112324729853736,0.842472623948323,0.0461088404884722,0.0491357216371956,0.0110219486609554,0.00191644348636688,0.254304413340487 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,0.400846084529803,0.0756315299990488,0.127733286815624,0.011087348090606,0.842364170321789,0.046129034765383,0.0491766451495284,0.011049622312511,0.00193589729339196,0.464833027470088 +"S1b",1,1,1,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,0.405907939424458,0.0764086574377509,0.129012461230401,0.0111605841676993,0.842479484739466,0.0460932357315975,0.0491198733047791,0.0110443784905514,0.00192158664025428,0.334294602837872 +"S1c",1,1,1,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,0.407967793915124,0.0766466687883462,0.129330321903309,0.0111360755262005,0.842511866298224,0.0461015049376835,0.0491018031400455,0.0110240858181335,0.00191735547661239,0.288407573923277 +"S2NoCD",0.593591118938596,0.582365621911992,0.705116455867408,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.593703622757395,0.582561633495118,0.706249983323194,0.0223572293275455,0.146520275764833,0.228783458335563,0.0867962070990575,0.406907175011621,0.0764857628938958,0.129161959754734,0.0111849702484567,0.842453436358219,0.0460995130135702,0.049162136254093,0.0110232564059888,0.00191909420686546,0.310203001792548 +"S3NoCD",0.46378531781744,0.415568056211066,0.586617239472126,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.463880507151998,0.415699320053362,0.586708781881545,0.0201156015599614,0.139591817454275,0.180822991967125,0.0824771154683174,0.410893918376555,0.0771596359153628,0.13002154727965,0.0112567726274374,0.842566021780609,0.0460728067506646,0.0490891975121309,0.0110179222026286,0.00191286787636638,0.231194614752874 +"S3b",0.463774630694015,0.415673744808273,0.587660544823951,0.022703218559012,0.147101677876022,0.233250693892965,0.0873282101842993,0.406897958993362,0.0765657243606348,0.12916424164248,0.0111938516834175,0.84245733212396,0.0460718832826625,0.0491420777172941,0.0110558113255998,0.00192827941971036,0.318156004167639 +"S3c",0.463731546127251,0.415538305063213,0.587311603486886,0.0213261904240776,0.143268049986543,0.207485881195491,0.0848645010202161,0.409017522509301,0.0768424095578439,0.12956240035588,0.0112182155362607,0.842485614704402,0.0460621493958521,0.0491521297235465,0.0110349049383035,0.00192076633511325,0.274243522611208 +"S3d",0.463883854439712,0.415752092299157,0.587221087548919,0.0207546147301295,0.141567271736428,0.195481611880112,0.0837050652172602,0.40984416843231,0.0769796311184294,0.1297896347637,0.0112424293950455,0.842510845247546,0.0460587342353947,0.0491389891816906,0.0110270863763496,0.00192123076545521,0.254532916078862 diff --git a/reproduction/outputs/Sen6_0_Discountclinicalresults_5y.csv b/reproduction/outputs/Sen6_0_Discountclinicalresults_5y.csv index fc6208a..2a670bd 100644 --- a/reproduction/outputs/Sen6_0_Discountclinicalresults_5y.csv +++ b/reproduction/outputs/Sen6_0_Discountclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,0.403047226128249,0.0760263148853383,0.12840956363145,0.0111267149068236,0.842461254812893,0.0461118957155039,0.049118855485952,0.0110334546540076,0.00192729365384067,0.399988053390932 -"S1b",1,1,1,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,0.408631980264935,0.0767122278432579,0.129370859426918,0.0112158820542419,0.8424572166305,0.0461045345921089,0.0491178381114376,0.0110465138362427,0.00192862473289225,0.294526778968184 -"S1c",1,1,1,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,0.409231958715491,0.0769956856216946,0.129978355787239,0.0112124528453459,0.842487284544981,0.0461078639931604,0.0491352633754891,0.0110153793798817,0.00191157483979592,0.26029455677229 -"S2NoCD",0.593443287202261,0.582273174807522,0.705545677347615,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535633225147,0.582295847461883,0.706034831690326,0.0214260856128922,0.143399662052018,0.208913322432459,0.0847853184386878,0.407655221861622,0.0767470760900907,0.129218216541159,0.011199194631369,0.842544394644732,0.046094763613817,0.0491127745862289,0.0109897656237673,0.00191086601779681,0.277612135628334 -"S3NoCD",0.463868670889904,0.415635368247289,0.587073562742789,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463789632372499,0.415622940758265,0.586809647097927,0.0197696669249095,0.138028597361208,0.171429592848262,0.081236444450917,0.411287856148879,0.07722846001244,0.130038331526943,0.0112026643175846,0.842626066479021,0.0461014349785822,0.0490229859734682,0.0109954420436182,0.00190926922852537,0.216839145396673 -"S3b",0.463662364229167,0.415627753354033,0.587309552953142,0.0217273072426316,0.144075656740584,0.212315561616708,0.085323826327292,0.407654369789789,0.0766217806454282,0.129340579136661,0.0111730977587919,0.84257351681126,0.0461000010925949,0.0490636336910152,0.0110096977534996,0.00191076692651309,0.284092335789576 -"S3c",0.463642228225923,0.415569605134916,0.587621281450251,0.0206710534473348,0.140931536559447,0.191763032350927,0.08324285525963,0.409917216243935,0.07702129939584,0.12970969386912,0.0111986612734943,0.842538118936641,0.0460823834781866,0.0491061374122304,0.0110204077894173,0.00191447077751689,0.249320504213185 -"S3d",0.463900420716114,0.415712328288473,0.587409792818855,0.0202416660684579,0.139590000283801,0.18228853527996,0.0822922365025336,0.410444613492492,0.077025066408215,0.129808877075041,0.0112098048644388,0.842570046688464,0.0461323938488098,0.0490485515602565,0.0110024025072699,0.00190357830414835,0.234231338952332 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,0.403687247969445,0.076043339045226,0.128491882068958,0.0111234434267872,0.842404538075766,0.0461249975109299,0.0491350481006971,0.0110626268806794,0.00192774403765099,0.400376813672669 +"S1b",1,1,1,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,0.408261469221123,0.0767148930126932,0.12942550981064,0.0111918986051741,0.842444102006296,0.0461405534347918,0.049119839074542,0.0110326731874807,0.0019206407489528,0.294383825212184 +"S1c",1,1,1,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,0.409414400075708,0.0768280371530212,0.129676147777572,0.0111990850471672,0.842566279080345,0.0460770376386533,0.0490825292231934,0.0110175512447196,0.00191369725957158,0.260088914224771 +"S2NoCD",0.593599520765188,0.582336120728919,0.705468838282451,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.59356654527618,0.582414633463478,0.70594630719989,0.0213965559374253,0.143850474561616,0.209480412096954,0.0850850980302915,0.408667539118558,0.0767385183547775,0.129416522072223,0.0112172729297281,0.842512558981358,0.0461063547945422,0.0490973671326712,0.0110198437844154,0.00191734574481944,0.277927102442024 +"S3NoCD",0.463672437596811,0.415434005363706,0.586089346363954,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.46370066773416,0.415527713942897,0.586531096227929,0.0197899392090461,0.138303277630978,0.171711091371148,0.0814794148216474,0.412123358096292,0.0772548393515772,0.130128312756924,0.0112117859678794,0.842519910814925,0.0460735235689768,0.0491516810272371,0.0110056311963728,0.00190514377766393,0.217315925410359 +"S3b",0.463904448997054,0.415785735654782,0.587675158368244,0.0217415888048102,0.144179021361847,0.212418250542373,0.0853294076058373,0.409418571728946,0.0768062462692041,0.129433160211189,0.0111817841277405,0.842414303912108,0.0460965101654088,0.0491882510131361,0.0110409375550577,0.00191758449244497,0.28441849116625 +"S3c",0.463840931188019,0.415695058927611,0.586925015622923,0.0206753702957292,0.141063374890625,0.191706805465128,0.0833410596328628,0.410579318361524,0.076984479764633,0.129710841719411,0.0112076528740334,0.842489353520781,0.0460832909926345,0.0491418310503537,0.0110238974057143,0.0019169509018325,0.24963076915198 +"S3d",0.463797376118965,0.41566768511288,0.586881023447397,0.02025846993191,0.139712240331005,0.182490438501157,0.0824624734254074,0.411214425863804,0.0771279852307872,0.129855466070449,0.0112227977270353,0.842491682442217,0.0460936959542376,0.0491366016280874,0.011022918093246,0.00191137314896782,0.234585140125143 diff --git a/reproduction/outputs/Sen6_0_Discounts1.csv b/reproduction/outputs/Sen6_0_Discounts1.csv index 307d11b..7988594 100644 --- a/reproduction/outputs/Sen6_0_Discounts1.csv +++ b/reproduction/outputs/Sen6_0_Discounts1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,92827349205.4231,2495.59458937662,529928094.955158,14.2467246759588,709840.639208566,0,0,NA,0 -"S1NoCD2",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,92978309018.8949,2499.57662668109,529999538.677107,14.2482098567725,709910.916211943,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,92902829112.159,2497.58563845852,529963816.816132,14.247467277715,709875.777710254,0,0,NA,0 -"S1a",37195779,626218800.231142,71281372.3281143,186100281,33119194.6945306,13388772,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,14905588,2814123,4756454,412031,0.209109161526637,0.0394790799908614,0.0667278679499271,0.0057803460643741,527524487,28873365,30786968,6925999,1208772,105211197488.536,2828.57894946994,530667768.51192,14.2668814252262,710515.492311842,332.984360093328,0.020156749267386,16519.7451075161,674.853103275993 -"S1b",37200476,626144171.819881,71252444.7802286,188422793,23802096.6205059,13372758,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,15103031,2841048,4796549,415612,0.211965091816623,0.0398729897446037,0.067317676113353,0.00583295073287542,527481440,28877807,30767692,6915814,1204950,101909010383.134,2739.45447319368,530366539.389009,14.2569826092819,710109.675990901,243.85988381706,0.0102579333230501,23772.8084339458,269.03678233549 -"S1c",37192813,625960445.075725,71159107.171146,189176712,20537776.6325788,13372239,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,15172732,2850944,4816068,416845,0.213222630288317,0.0400643587776213,0.0676802758137028,0.0058579290349644,527395566,28830750,30734973,6903078,1206962,102900329677.61,2766.67241269463,530129569.91612,14.2535486604931,709910.76061196,271.077823318009,0.0068239845342557,39724.2728141054,70.1214033947326 +"S1NoCD",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,185724530860.355,2496.67507990631,1059845409.25035,14.2473889128735,709872.77056377,0,0,NA,0 +"S1NoCD2",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,186033235252.932,2500.83578531112,1059900379.81023,14.2481895511329,709908.641771333,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,185878883056.643,2498.75542810618,1059872894.53029,14.2477892311368,709890.706167551,0,0,NA,0 +"S1a",74380275,1252107231.24309,142568770.421589,372100831,66270673.1777553,26745802,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,29815042,5625494,9500837,824680,0.209127440124749,0.0394581084157834,0.0666403797402835,0.00578443650430136,1054730269,57758498,61574433,13835312,2423951,210298062988.674,2827.33645430423,1061052827.37569,14.2652447490371,710434.900997551,330.661374397926,0.0178558361635819,18518.3920466481,562.130433781189 +"S1b",74383024,1252030977.73496,142410669.767258,376764647,47607118.2897207,26748888,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,30192660,5683507,9596337,830158,0.212011221134933,0.0399092779304288,0.0673849579928479,0.00582932445551117,1054810413,57710159,61499603,13827904,2405886,203807677144.238,2739.97568510038,1060522850.47389,14.2575925721155,710139.652920677,243.300605194074,0.0102036592420163,23844.4463327645,266.882356906775 +"S1c",74393892,1252166866.96087,142379317.946113,378416895,41063273.6656893,26758496,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,30350312,5702044,9621386,828456,0.213165173410135,0.0400482603952217,0.0675757275620708,0.00581865408509366,1054965444,57726777,61483651,13803995,2400849,205585395445.529,2763.47143453026,1060470315.25251,14.2548035429107,709976.705711003,266.796354623955,0.00741463003715026,35982.4230321943,103.935147233657 diff --git a/reproduction/outputs/Sen6_0_Discounts1_5y.csv b/reproduction/outputs/Sen6_0_Discounts1_5y.csv index efe7b52..17ad9fe 100644 --- a/reproduction/outputs/Sen6_0_Discounts1_5y.csv +++ b/reproduction/outputs/Sen6_0_Discounts1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,92827349205.4231,2495.59458937662,529928094.955158,14.2467246759588,709840.639208566,0,0,NA,0 -"S1NoCD",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,92978309018.8949,2499.57662668109,529999538.677107,14.2482098567725,709910.916211943,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,92902829112.159,2497.58563845852,529963816.816132,14.247467277715,709875.777710254,0,0,NA,0 -"S1a",37197502,626089852.781592,71222083.952196,122776626,28487982.7184844,16327137,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,14992350,2827989,4776515,413886,0.210501422705671,0.0397066309081624,0.0670650833975313,0.00581120316948039,527456443,28870190,30752817,6907934,1206659,101593628148.474,2731.19491057422,530443726.842454,14.2601975488153,710278.682530193,231.618283893131,0.0119876920428705,19321.3408439935,367.766318250448 -"S1b",37190655,625992698.014129,71214502.2789584,123717512,20974577.9720441,16327973,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,15197291,2852978,4811387,417126,0.213401631882082,0.0400617558039574,0.0675618988552786,0.00585731819575248,527372066,28861102,30747408,6915037,1207305,99147551250.5217,2665.92646057247,530160005.562289,14.25519409546,710093.778312426,166.349833891377,0.00698423868748854,23817.8907300768,182.862100483035 -"S1c",37195162,626110981.941873,71210037.1648892,124047387,18535585.0615731,16324587,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,15221449,2863867,4834566,417049,0.213754262826099,0.0402171816505112,0.0678916370848874,0.00585660416149354,527490541,28868640,30764128,6896850,1196858,99801217926.1646,2683.17739619375,530199954.883661,14.2545408159174,710043.863399678,183.600769512658,0.00633095914496096,29000.466644741,132.947187735466 +"S1NoCD2",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,185724530860.355,2496.67507990631,1059845409.25035,14.2473889128735,709872.77056377,0,0,NA,0 +"S1NoCD",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,186033235252.932,2500.83578531112,1059900379.81023,14.2481895511329,709908.641771333,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,185878883056.643,2498.75542810618,1059872894.53029,14.2477892311368,709890.706167551,0,0,NA,0 +"S1a",74386318,1252092577.05249,142511621.315835,245523949,57058348.8537602,32655914,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,30028808,5656584,9558038,827432,0.210711293035183,0.0396920893031161,0.0670684812350664,0.00580606684816418,1054768469,57752767,61521629,13851433,2413714,203290806711.172,2732.90589152661,1060803037.08176,14.2607278543046,710303.486823703,232.070106215491,0.0125383031717003,18508.8925540807,394.845052369521 +"S1b",74385413,1252007175.89227,142455061.307373,247448362,41936465.8685008,32651747,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,30368698,5706469,9627370,832514,0.213180898743035,0.0400580291611207,0.0675818037747859,0.0058440464828673,1054746061,57768304,61498391,13812986,2404656,198298896719.68,2665.83041919361,1060342608.87995,14.2547115908323,710069.749122422,164.994633882498,0.00652203969943521,25298.0112796287,161.107351089246 +"S1c",74390720,1252048090.68724,142295860.364143,248074520,37009575.8207896,32668233,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,30456632,5715293,9646702,833108,0.214037372008291,0.0401648578207,0.0677932722379522,0.00585475921694439,1054933501,57690667,61453687,13794504,2396041,199278771241.365,2678.81223950198,1060261851.16163,14.2526090776057,709951.641640785,177.976454190868,0.00441952647285326,40270.480397409,42.9998694517417 diff --git a/reproduction/outputs/Sen6_0_Discounts2.csv b/reproduction/outputs/Sen6_0_Discounts2.csv index ad19576..9c31ebd 100644 --- a/reproduction/outputs/Sen6_0_Discounts2.csv +++ b/reproduction/outputs/Sen6_0_Discounts2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078563,364522748.573687,50166624.1671238,110968095,9653605.82348446,7738507,0.0172779795723912,0.141222462720366,0.158929640922804,0.0870932535738703,11438971,2125413,3543389,304919,0.228019548652357,0.0423670724368348,0.0706323987078669,0.00607812475051542,298790021,18633807,22502661,5543543,1025792,67978101358.6265,3078.91873935031,307350490.064811,13.9207651360648,692959.338063891,0,0,NA,0 -"S2a",22077788,364622606.499305,50226922.8843361,108797477,18511083.7047635,7734136,0.0229898067769556,0.157327004308664,0.269003214018226,0.0973502415391329,11192847,2087413,3500787,300763,0.22284556483333,0.041559643317329,0.0696994121670902,0.00598808333714978,298828425,18622586,22524521,5579724,1036307,73774185782.3801,3341.55694322185,307671897.941364,13.9358117734151,693449.031727535,262.638203871539,0.0150466373503253,17454.943437303,489.693663644721 +"S2NoCD",44156404,729084497.054691,100330759.79117,221928932,19330951.6588092,15481473,0.0172596709453046,0.141645486548806,0.159259990701265,0.08725337635747,22917076,4253860,7098458,609501,0.228415254182267,0.0423983632622146,0.070750565577046,0.00607491661847899,597619551,37246010,44990133,11123560,2050468,136124332102.838,3082.77667046524,614729143.469625,13.9216305627973,692998.7514694,0,0,NA,0 +"S2a",44164773,729329891.015329,100492048.993736,217625447,37010683.2532179,15485858,0.0230145995823502,0.157180410449991,0.268827891528291,0.0973046709934024,22383331,4181008,7006346,603148,0.222737333193348,0.0416053612386849,0.0697204014661571,0.00600194747783078,597700094,37284225,45068617,11147317,2064302,147612114723.849,3342.30439096446,615416265.999239,13.9345506428673,693385.227752401,259.527720499224,0.0129200800700122,20087.1603808086,386.476283001481 diff --git a/reproduction/outputs/Sen6_0_Discounts2_5y.csv b/reproduction/outputs/Sen6_0_Discounts2_5y.csv index f1161f7..d0fd8da 100644 --- a/reproduction/outputs/Sen6_0_Discounts2_5y.csv +++ b/reproduction/outputs/Sen6_0_Discounts2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22074342,364499892.795735,50179989.1467565,72492409,9769650.24862608,9434235,0.0208917555301636,0.141988942022567,0.159733364688847,0.0874666663868567,11472370,2126666,3551252,304704,0.228624401779918,0.0423807584688858,0.070770282345299,0.00607222132130921,298757005,18626945,22501053,5562438,1027303,68198452610.1151,3089.48971661829,307327847.064593,13.9224012686128,693030.573714022,0,0,NA,0 -"S2a",22077777,364514085.756087,50214778.8994209,71673455,16290550.2537317,9435494,0.0250429167756047,0.153202361136407,0.241328632393267,0.094789501013715,11245330,2100490,3507989,302346,0.223944628383691,0.0418301154767053,0.0698596922437202,0.00602105608401846,298734836,18629376,22530917,5562183,1028646,72055390303.5079,3263.70677190497,307521349.116734,13.9289996957907,693186.278017629,174.217055286689,0.00659842717785786,26402.8154878035,155.704303606297 +"S2NoCD",44157029,729047563.461063,100380900.154714,145000421,19524492.074223,18863743,0.0209029627109113,0.141781753914197,0.159519185673724,0.0873704363140082,22925265,4254784,7099566,609563,0.228382739790797,0.0423863901742486,0.0707262635527043,0.00607249983871931,597538799,37245010,45040554,11117169,2054803,136358873736.606,3088.04457239652,614694012.163514,13.9206379161858,692943.851236892,0,0,NA,0 +"S2a",44154576,729145856.381239,100448839.030434,143361789,32595478.4145126,18878233,0.0250078581664384,0.153560443203067,0.241814960491553,0.0950258179639202,22519648,4200194,7025459,605531,0.224190226759883,0.0418142612751096,0.0699406689794734,0.00602825284836329,597564735,37286040,45033303,11135908,2066352,144286219339.485,3267.75234665339,615140303.22925,13.9315187451749,693308.184912092,179.707774256871,0.0108808289891495,16516.0002455766,364.333675200585 diff --git a/reproduction/outputs/Sen6_0_Discounts3.csv b/reproduction/outputs/Sen6_0_Discounts3.csv index 9bad801..51d2485 100644 --- a/reproduction/outputs/Sen6_0_Discounts3.csv +++ b/reproduction/outputs/Sen6_0_Discounts3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17243525,260017880.24558,41691838.3900313,80059027,7819384.14256,5815322,0.0183575174217772,0.137156256672018,0.154366597029931,0.0863650846874626,9754415,1816466,3038101,261338,0.233964616977224,0.043568863119126,0.0728704014339272,0.00626832517086814,207433146,15294590,18682841,4808648,895345,57710008551.5133,3346.76399120907,218436256.441118,12.6677263750375,630039.554760666,0,0,NA,0 -"S3a",17245589,260114350.889536,41778507.6419587,79305268,11012874.3912697,5816924,0.0210701415875502,0.143601112787989,0.204102307078173,0.090802566674972,9648241,1803612,3027939,260144,0.230937904309204,0.0431708096291264,0.0724759971310943,0.00622674228168777,207442211,15303706,18733677,4824249,900624,61268007224.7443,3552.67699031586,218598437.880415,12.6756144936781,630228.047693587,205.912999106791,0.00788811864055639,26104.1965124738,188.492932921043 -"S3b",17248093,260143538.873804,41765340.0149969,77789956,17179218.0534133,5809490,0.0272123567386269,0.156225870536493,0.292983388954392,0.0989344402695251,9481831,1779958,2992091,258625,0.227026309293671,0.0426180655864614,0.0716405277420372,0.00619233555639998,207483725,15287322,18724587,4837601,899769,63624999198.9553,3688.81355167527,218793326.615176,12.6850734521883,630564.859057742,342.049560466199,0.0173470771508519,19717.9938436719,525.304297076422 -"S3c",17249568,260123652.106259,41796963.3084409,78552778,14093542.3037528,5811921,0.0239564020668036,0.149872778444183,0.249488678363603,0.0947819160826065,9556493,1794042,3007246,258985,0.228640844778072,0.0429227833314315,0.0719489111639047,0.00619626354404789,207434647,15324709,18727689,4823824,902793,62103127614.4747,3600.27147430444,218692117.107242,12.6781213945325,630305.798252318,253.507483095375,0.0103950194949576,24387.3985246826,266.243491652422 -"S3d",17250373,260166499.185349,41788450.6328664,78909896,12694598.7095123,5812281,0.0225871693478081,0.14720440466007,0.229100157335109,0.0931309605323503,9596955,1798651,3013620,260246,0.229655678893537,0.0430418207126676,0.0721160979734865,0.00622770157923294,207483596,15310784,18731510,4829309,900292,62445799073.8093,3619.96804786826,218689857.965539,12.6773987997557,630249.971939919,273.204056659189,0.0096724247182518,28245.6637934493,210.417179253418 +"S3NoCD",34500334,520264617.028559,83469550.1049324,160191877,15617539.1621454,11630123,0.018371612334161,0.136660912007116,0.153889981724535,0.0860423303941354,19525292,3631989,6073558,522424,0.23392113621619,0.0435127420171081,0.0727637562723739,0.00625885726403513,415002016,30608834,37422882,9624470,1788687,115393106843.54,3344.69535406642,437057823.162521,12.668220057305,630066.307511183,0,0,NA,0 +"S3a",34507415,520428950.960441,83482575.6405212,158676520,22030097.8695766,11639538,0.0210425232718254,0.143591703407669,0.204088019848658,0.0908272943093332,19287934,3609226,6045313,521405,0.231041434119792,0.043233285177274,0.072414069087079,0.00624567457340066,415152628,30610103,37407716,9641236,1794702,122423689898.09,3547.7502414507,437381358.392527,12.6749963273843,630202.066127766,203.054887384279,0.00677627007934767,29965.5835742348,135.758616583073 +"S3b",34499539,520396932.389974,83618001.6376853,155590263,34428826.1327912,11625591,0.0272677362023387,0.156355277894248,0.293211112522871,0.0990494988470827,18988453,3564625,5980823,516662,0.227085706762959,0.0426298755074946,0.0715255433383203,0.00617883697147755,414988556,30607762,37472866,9688489,1813970,127296658688.636,3689.80752724366,437670760.97409,12.6862785318404,630624.119064775,345.112173177236,0.0180584745353762,19110.8153959055,557.811553591629 +"S3c",34496334,520227370.495019,83568350.903854,157099275,28171360.7955484,11622564,0.0239564406652199,0.14984119401007,0.249428440470547,0.0948714951513754,19145218,3585036,6010150,518449,0.229096515522087,0.0428994465156386,0.0719189733313599,0.00620389171728995,414875686,30589301,37479876,9661353,1804425,124195481660.429,3600.25159950123,437363545.965671,12.6785514647925,630327.321640123,255.556245434806,0.0103314074874916,24735.8596342475,261.014128939831 +"S3d",34507664,520495018.435642,83555471.4245087,157877292,25364365.9811382,11630839,0.0225793272116635,0.14694733242596,0.229001602594022,0.0929007877476101,19209915,3595849,6028084,520340,0.229906129095997,0.0430354701935804,0.0721446949820192,0.00622747967462694,415141325,30594930,37472224,9653084,1805226,124862452608.862,3618.39771619609,437518341.968706,12.6788745238943,630325.328478521,273.702362129663,0.010654466589358,25688.9784048922,259.020967338234 diff --git a/reproduction/outputs/Sen6_0_Discounts3_5y.csv b/reproduction/outputs/Sen6_0_Discounts3_5y.csv index e9daa46..3290f5e 100644 --- a/reproduction/outputs/Sen6_0_Discounts3_5y.csv +++ b/reproduction/outputs/Sen6_0_Discounts3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17254548,260185517.250271,41753986.9530892,52456874,7922835.39457538,7061036,0.0221592886073816,0.13726133321656,0.154573171523665,0.0864947424330528,9767617,1818208,3040076,262205,0.233932558607492,0.043545733777298,0.0728092386342779,0.00627975959025394,207533583,15301679,18724752,4815426,897482,57864310923.5952,3353.56863150488,218572819.44283,12.6675482570062,630023.844218806,0,0,NA,0 -"S3a",17251608,260177737.708618,41735216.681199,52193377,10112285.5219638,7056308,0.0239901655742498,0.141620447019917,0.188896901320193,0.0892874240346538,9673981,1809610,3026757,259927,0.23179419610772,0.0433593052558704,0.0725228533763311,0.00622800168944835,207543323,15307443,18697708,4818609,897810,60089152167.6302,3483.1044252588,218633446.064064,12.673221305751,630177.960862291,129.535793753925,0.00567304874478936,22833.5414662006,154.116643485613 -"S3b",17246874,260180750.367826,41770771.1055183,51592135,14901907.2426103,7060341,0.0287001627876402,0.151909252445312,0.258476623670136,0.0962303406481393,9537491,1786791,3000373,258790,0.228329301748035,0.0427761076156898,0.0718294855611038,0.00619548055137079,207513062,15306657,18723252,4827550,898750,61869748507.0021,3587.30216890331,218763932.889481,12.6842657335747,630625.984509833,233.733537398428,0.0167174765685054,13981.3886647681,602.14029102691 -"S3c",17246125,260144349.893699,41792941.9345714,51894923,12432862.6252413,7060467,0.0261601311174318,0.146548593395628,0.223441477763239,0.0926749735395,9621451,1801612,3014035,259735,0.23021712649621,0.0431080444832167,0.0721182778833468,0.00621480537088358,207459068,15294280,18748666,4834049,901039,60807623937.5119,3525.87169219241,218659411.906197,12.6787560629531,630411.931455463,172.303060687534,0.0112078059468885,15373.4871485144,388.087236656924 -"S3d",17255729,260233693.824386,41777900.3893267,52047317,11356969.6042882,7062160,0.0251240111093077,0.14426968081771,0.207339855216131,0.0910648854849654,9643777,1802264,3018596,260225,0.23083441030138,0.0431391712653046,0.0722534156065723,0.00622877161310102,207557193,15328896,18715546,4823282,894293,60941413667.9918,3531.66265348696,218712958.12271,12.674802561092,630208.465401115,178.094021982078,0.00725430408581751,24550.1180919973,184.621182308882 +"S3NoCD",34491937,520096793.944658,83394436.3897572,104866546,15798843.6062051,14116443,0.0221440059305719,0.13704346682043,0.154368086406791,0.0863943143443837,19479590,3630576,6075819,523166,0.233583807784959,0.0435349905481935,0.0728564070102194,0.00627339211880875,414917152,30599570,37365292,9614469,1790750,115570166575.01,3350.64297998138,436927836.474174,12.6675355018239,630026.132111215,0,0,NA,0 +"S3a",34494037,520214111.090036,83457292.8145667,104351592,20245608.2892442,14129448,0.0240307345372679,0.14177714164029,0.189041590205167,0.0894698764862355,19332282,3614629,6055063,518761,0.231642812126129,0.0433111221092604,0.0725528326620145,0.00621588578427331,414968911,30599997,37426814,9615582,1787056,120160874412.554,3483.52599066771,437149997.768731,12.6732048721561,630176.717617135,132.883010686333,0.00566937033213755,23438.7600212088,150.585505920462 +"S3b",34509196,520537137.764278,83620080.9934994,103218767,29823148.4264926,14132996,0.0287201148667908,0.151759070463881,0.258228121857447,0.0959834805484866,19135380,3582069,6004729,516649,0.228837137834004,0.0428374256212269,0.0718096530002979,0.00617852785911753,415119150,30640730,37483240,9661621,1802895,123796077466.842,3587.33589350625,437667748.693372,12.6826411340725,630544.720810121,236.692913524866,0.0151056322486234,15669.1828338689,518.588698906242 +"S3c",34504471,520423616.303641,83513343.4596301,103824096,24853846.8628113,14121585,0.0261578150769642,0.14647414308412,0.223082059564315,0.0926287674905986,19220385,3595075,6024956,518536,0.23014747349076,0.0430479112806427,0.0721436329861758,0.00620901976281979,415113845,30619979,37421385,9639642,1802009,121485915693.67,3520.8746047337,437449142.201033,12.6780422804057,630381.239415553,170.23162475232,0.0105067785818065,16202.0759671373,355.107304338017 +"S3d",34501231,520389346.039061,83507083.8292405,104079260,22711873.9482136,14135933,0.0251554674459531,0.144172895875718,0.20738377463961,0.0911334097630808,19266710,3605577,6035420,519637,0.230719468535119,0.0431768999067536,0.0722743475552509,0.00622266969665208,415086795,30631737,37413709,9638221,1794998,121822210447.546,3530.95257521525,437363184.796397,12.6767414413821,630306.11949389,180.309595233864,0.00920593955818028,19586.224099597,279.987382675055 diff --git a/reproduction/outputs/Sen6_0_Discountsall.csv b/reproduction/outputs/Sen6_0_Discountsall.csv index b6ffdda..649b201 100644 --- a/reproduction/outputs/Sen6_0_Discountsall.csv +++ b/reproduction/outputs/Sen6_0_Discountsall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37195779,105211197488.536,2828.57894946994,530667768.51192,14.2668814252262,16519.7451075161,674.853103275993 -"S3b",17248093,63624999198.9553,3688.81355167527,218793326.615176,12.6850734521883,19717.9938436719,525.304297076422 -"S2a",22077788,73774185782.3801,3341.55694322185,307671897.941364,13.9358117734151,17454.943437303,489.693663644721 -"S1b",37200476,101909010383.134,2739.45447319368,530366539.389009,14.2569826092819,23772.8084339458,269.03678233549 -"S3c",17249568,62103127614.4747,3600.27147430444,218692117.107242,12.6781213945325,24387.3985246826,266.243491652422 -"S3d",17250373,62445799073.8093,3619.96804786826,218689857.965539,12.6773987997557,28245.6637934493,210.417179253418 -"S3a",17245589,61268007224.7443,3552.67699031586,218598437.880415,12.6756144936781,26104.1965124738,188.492932921043 -"S1c",37192813,102900329677.61,2766.67241269463,530129569.91612,14.2535486604931,39724.2728141054,70.1214033947326 -"S1NoCD",37196486,92827349205.4231,2495.59458937662,529928094.955158,14.2467246759588,NA,0 -"S2NoCD",22078563,67978101358.6265,3078.91873935031,307350490.064811,13.9207651360648,NA,0 -"S3NoCD",17243525,57710008551.5133,3346.76399120907,218436256.441118,12.6677263750375,NA,0 +"S1a",74380275,210298062988.674,2827.33645430423,1061052827.37569,14.2652447490371,18518.3920466481,562.130433781189 +"S3b",34499539,127296658688.636,3689.80752724366,437670760.97409,12.6862785318404,19110.8153959055,557.811553591629 +"S2a",44164773,147612114723.849,3342.30439096446,615416265.999239,13.9345506428673,20087.1603808086,386.476283001481 +"S1b",74383024,203807677144.238,2739.97568510038,1060522850.47389,14.2575925721155,23844.4463327645,266.882356906775 +"S3c",34496334,124195481660.429,3600.25159950123,437363545.965671,12.6785514647925,24735.8596342475,261.014128939831 +"S3d",34507664,124862452608.862,3618.39771619609,437518341.968706,12.6788745238943,25688.9784048922,259.020967338234 +"S3a",34507415,122423689898.09,3547.7502414507,437381358.392527,12.6749963273843,29965.5835742348,135.758616583073 +"S1c",74393892,205585395445.529,2763.47143453026,1060470315.25251,14.2548035429107,35982.4230321943,103.935147233657 +"S1NoCD",74388747,185724530860.355,2496.67507990631,1059845409.25035,14.2473889128735,NA,0 +"S2NoCD",44156404,136124332102.838,3082.77667046524,614729143.469625,13.9216305627973,NA,0 +"S3NoCD",34500334,115393106843.54,3344.69535406642,437057823.162521,12.668220057305,NA,0 diff --git a/reproduction/outputs/Sen6_0_Discountsall_5y.csv b/reproduction/outputs/Sen6_0_Discountsall_5y.csv index 7cc365e..c480e42 100644 --- a/reproduction/outputs/Sen6_0_Discountsall_5y.csv +++ b/reproduction/outputs/Sen6_0_Discountsall_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S3b",17246874,61869748507.0021,3587.30216890331,218763932.889481,12.6842657335747,13981.3886647681,602.14029102691 -"S3c",17246125,60807623937.5119,3525.87169219241,218659411.906197,12.6787560629531,15373.4871485144,388.087236656924 -"S1a",37197502,101593628148.474,2731.19491057422,530443726.842454,14.2601975488153,19321.3408439935,367.766318250448 -"S3d",17255729,60941413667.9918,3531.66265348696,218712958.12271,12.674802561092,24550.1180919973,184.621182308882 -"S1b",37190655,99147551250.5217,2665.92646057247,530160005.562289,14.25519409546,23817.8907300768,182.862100483035 -"S2a",22077777,72055390303.5079,3263.70677190497,307521349.116734,13.9289996957907,26402.8154878035,155.704303606297 -"S3a",17251608,60089152167.6302,3483.1044252588,218633446.064064,12.673221305751,22833.5414662006,154.116643485613 -"S1c",37195162,99801217926.1646,2683.17739619375,530199954.883661,14.2545408159174,29000.466644741,132.947187735466 -"S1NoCD",37197623,92978309018.8949,2499.57662668109,529999538.677107,14.2482098567725,NA,0 -"S2NoCD",22074342,68198452610.1151,3089.48971661829,307327847.064593,13.9224012686128,NA,0 -"S3NoCD",17254548,57864310923.5952,3353.56863150488,218572819.44283,12.6675482570062,NA,0 +"S3b",34509196,123796077466.842,3587.33589350625,437667748.693372,12.6826411340725,15669.1828338689,518.588698906242 +"S1a",74386318,203290806711.172,2732.90589152661,1060803037.08176,14.2607278543046,18508.8925540807,394.845052369521 +"S2a",44154576,144286219339.485,3267.75234665339,615140303.22925,13.9315187451749,16516.0002455766,364.333675200585 +"S3c",34504471,121485915693.67,3520.8746047337,437449142.201033,12.6780422804057,16202.0759671373,355.107304338017 +"S3d",34501231,121822210447.546,3530.95257521525,437363184.796397,12.6767414413821,19586.224099597,279.987382675055 +"S1b",74385413,198298896719.68,2665.83041919361,1060342608.87995,14.2547115908323,25298.0112796287,161.107351089246 +"S3a",34494037,120160874412.554,3483.52599066771,437149997.768731,12.6732048721561,23438.7600212088,150.585505920462 +"S1c",74390720,199278771241.365,2678.81223950198,1060261851.16163,14.2526090776057,40270.480397409,42.9998694517417 +"S1NoCD",74388425,186033235252.932,2500.83578531112,1059900379.81023,14.2481895511329,NA,0 +"S2NoCD",44157029,136358873736.606,3088.04457239652,614694012.163514,13.9206379161858,NA,0 +"S3NoCD",34491937,115570166575.01,3350.64297998138,436927836.474174,12.6675355018239,NA,0 diff --git a/reproduction/outputs/Sen7_3_Discount_CEplot-1.png b/reproduction/outputs/Sen7_3_Discount_CEplot-1.png index d9820d3..bc5d4ee 100644 Binary files a/reproduction/outputs/Sen7_3_Discount_CEplot-1.png and b/reproduction/outputs/Sen7_3_Discount_CEplot-1.png differ diff --git a/reproduction/outputs/Sen7_3_Discount_CEplot_5y-1.png b/reproduction/outputs/Sen7_3_Discount_CEplot_5y-1.png index 595e760..0b59cb6 100644 Binary files a/reproduction/outputs/Sen7_3_Discount_CEplot_5y-1.png and b/reproduction/outputs/Sen7_3_Discount_CEplot_5y-1.png differ diff --git a/reproduction/outputs/Sen7_3_Discountceplane.csv b/reproduction/outputs/Sen7_3_Discountceplane.csv index 07910a0..cd6c024 100644 --- a/reproduction/outputs/Sen7_3_Discountceplane.csv +++ b/reproduction/outputs/Sen7_3_Discountceplane.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,69382514865.3417,1865.2690595526,0,1865.2690595526,414538063.162696,11.1443787346844,0,11.1443787346844,0,0,NA,NA,0 -"S1a",37195779,1,78988588612.6422,2123.59011522899,0,2123.59011522899,415048182.916947,11.1584753451984,0,11.1584753451984,258.321055676396,0.014096610513981,18325.0473878237,17747.5307178108,446.509470022633 -"S1b",37200476,1,76461197768.4769,2055.38224211101,0,2055.38224211101,414832041.59623,11.1512562795226,0,11.1512562795226,190.113182558415,0.00687754483822545,27642.5944185438,25820.1061500554,153.764059352921 -"S1c",37192813,1,77318972105.8953,2078.86862727741,0,2078.86862727741,414653652.849152,11.1487574991747,0,11.1487574991747,213.59956772481,0.00437876449031549,48780.7846704768,43696.5076013981,5.33865679090377 -"S2NoCD",22078563,0.593556763930821,51195392088.1397,2318.78279796288,1202.9720940537,1865.2690846254,240914015.067657,10.9116709754913,11.4842181071536,11.1443788844863,0,0,NA,NA,0.00746502226684242 -"S2a",22077788,0.593535928947491,55740228536.7613,2524.71980149285,1202.9720940537,1987.47684742281,241147117.181689,10.9226122282581,11.4842181071536,11.150884840121,122.207762797411,0.0065059556346867,18783.9834237198,18822.0679953945,203.097483959165 -"S3NoCD",17243525,0.463572330217334,43585079096.4942,2527.62002528452,1292.87585012393,1865.2690846254,173193983.206107,10.0440010500235,12.095308050851,11.1443788844863,0,0,NA,NA,0.00746502226684242 -"S3a",17245589,0.463627818482614,46423704300.026,2691.91758542001,1292.87585012393,1941.51051782538,173312928.019824,10.0496960712576,12.095308050851,11.1469054312903,76.2414331999803,0.00252654680395992,30176.1412377104,28849.3323169204,50.0933720202884 -"S3b",17248093,0.463695135641656,48252461324.4413,2797.5534063065,1292.87585012393,1990.58751363496,173460430.655696,10.0567889247638,12.095308050851,11.1500566481719,125.318429009558,0.00567776368561823,22071.7937463634,21108.541216104,158.577220293577 -"S3c",17249568,0.463734789319606,47056539449.2717,2727.98364859176,1292.87585012393,1958.38526269733,173385532.23841,10.0515869289254,12.095308050851,11.1475634669468,93.1161780719276,0.00318458246052522,29239.6818817404,26412.7104978867,66.1204099765746 -"S3d",17250373,0.463756430818419,47356022542.0812,2745.21730875508,1292.87585012393,1966.40854130833,173385479.345343,10.0511147988129,12.095308050851,11.1473002843827,101.139456682922,0.00292139989645435,34620.2027342006,30588.2720787578,44.9380031620385 +"S1NoCDAvg",74388586,1,138822291283.827,1866.17730956503,0,1866.17730956503,829028733.525985,11.144569054263,0,11.144569054263,0,0,NA,NA,0 +"S1a",74380275,1,157886317266.186,2122.6906900544,0,2122.6906900544,829882712.533117,11.1572955670454,0,11.1572955670454,256.513380489369,0.0127265127823488,20155.8262562815,19821.8607947787,379.812258628081 +"S1b",74383024,1,152914677120.41,2055.77387012942,0,2055.77387012942,829494032.024955,11.1516578302188,0,11.1516578302188,189.596560564393,0.0070887759557845,26746.0224088025,25892.7443652044,164.842237224919 +"S1c",74393892,1,154475292878.787,2076.4512882158,0,2076.4512882158,829462689.506534,11.1496074100618,0,11.1496074100618,210.273978650774,0.00503835579871392,41734.6426198102,39721.0321621392,41.6438112849137 +"S2NoCD",44156404,0.593591118938596,102511836117.178,2321.56214797695,1201.05307538333,1866.17730956503,481847557.683567,10.9122916278139,11.4838279235822,11.144569054263,0,0,NA,NA,0 +"S2a",44164773,0.593703622757395,111527223359.312,2525.25295124493,1201.05307538333,1987.23533893725,482358788.680347,10.9217993417593,11.4838279235822,11.1501495184607,121.058029372224,0.00558046419766356,21693.1826966847,21423.741231381,157.965180511004 +"S3NoCD",34500334,0.46378531781744,87147515107.9228,2525.99047614794,1295.48861092995,1866.17730956503,346536201.74847,10.0444303451807,12.0961061862905,11.144569054263,0,0,NA,NA,0 +"S3a",34507415,0.463880507151998,92759974975.707,2688.11717643025,1295.48861092995,1941.50185616859,346780019.65528,10.0494348723392,12.0961061862905,11.1466952592013,75.3245466035632,0.00212620493828553,35426.757433976,32396.0076843055,30.9857003106736 +"S3b",34499539,0.463774630694015,96533122890.8993,2798.09892215949,1295.48861092995,1992.36115309745,346983955.051516,10.0576403369192,12.0961061862905,11.1507174398159,126.183843532422,0.00614838555291186,20523.0856859101,20598.684041531,181.235434113187 +"S3c",34496334,0.463731546127251,94096368027.4299,2727.72080730172,1295.48861092995,1959.65986176666,346758703.786504,10.052045060397,12.0961061862905,11.1482105600013,93.4825522016345,0.00364150573825839,25671.4004922437,26492.1701500608,88.5927347113611 +"S3d",34507664,0.463883854439712,94690116841.6979,2744.03149519764,1295.48861092995,1967.44426740527,346877136.052445,10.0521767005858,12.0961061862905,11.1479602982589,101.266957840238,0.00339124399581436,29861.3010344365,28147.5620012545,68.295241950429 diff --git a/reproduction/outputs/Sen7_3_Discountceplane_5y.csv b/reproduction/outputs/Sen7_3_Discountceplane_5y.csv index 8ae004c..6f81652 100644 --- a/reproduction/outputs/Sen7_3_Discountceplane_5y.csv +++ b/reproduction/outputs/Sen7_3_Discountceplane_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","PropAgents","Cost","CostpAgent","CostpAgentExcluded","CostpAgentAll","QALY","QALYpAgent","QALYpAgentExcluded","QALYpAgentAll","IncrementalCosts","IncrementalQALY","ICERAdj","ICER","INMB" -"S1NoCDAvg",37197054,1,69382514865.3417,1865.2690595526,0,1865.2690595526,414538063.162696,11.1443787346844,0,11.1443787346844,0,0,NA,NA,0 -"S1a",37197502,1,76233049354.3059,2049.41313947119,0,2049.41313947119,414888345.892525,11.1536614983588,0,11.1536614983588,184.144079918593,0.00928276367442571,19837.2043474418,20898.9319414247,279.994103802717 -"S1b",37190655,1,74352383548.6806,1999.22221183468,0,1999.22221183468,414673206.381945,11.149930174178,0,11.149930174178,133.953152282087,0.00555143949363845,24129.4447026915,26448.8469858668,143.61882239976 -"S1c",37195162,1,74927136725.5007,2014.43232658862,0,2014.43232658862,414704948.175006,11.1494325034801,0,11.1494325034801,149.163267036025,0.0050537687956691,29515.2534805021,32740.5618588505,103.525172747439 -"S2NoCD",22074342,0.593443287202261,51361753549.0855,2326.76260742384,1191.63555559718,1865.2690846254,240891915.913164,10.9127563536509,11.4824739933904,11.1443788844863,0,0,NA,NA,0.0074650221504271 -"S2a",22077777,0.593535633225147,54432158311.1104,2465.47278338351,1191.63555559718,1947.70334121711,241039404.019419,10.9177388656212,11.4824739933904,11.1472835717254,82.4342565917027,0.00290468723915716,28379.7358560443,27839.4064652496,62.8075703883078 -"S3NoCD",17254548,0.463868670889904,43698225565.3525,2532.56275188156,1287.91683953808,1865.2690846254,173302715.863562,10.0438861605393,12.0965412922095,11.1443788844863,0,0,NA,NA,0.00746502226684242 -"S3a",17251608,0.463789632372499,45514928489.8059,2638.30064361571,1287.91683953808,1914.21084759302,173345067.882346,10.0480527891862,12.0965412922095,11.146473562473,48.9417629676186,0.00209467798669749,23364.8146772102,25377.3255781984,55.7996013894444 -"S3b",17246874,0.463662364229167,46894607074.7492,2719.02068019684,1287.91683953808,1951.46582975536,173436965.103661,10.0561391649096,12.0965412922095,11.1504836178874,86.1967451299611,0.00610473340109152,14119.6575618764,15217.323252373,219.047389946762 -"S3c",17246125,0.463642228225923,46057749842.9718,2670.61440427759,1287.91683953808,1928.99381941646,173359596.803533,10.0520897768938,12.0965412922095,11.1486472361487,63.7247347910602,0.00426835166236117,14929.5887105536,16828.1458359742,149.700313349254 -"S3d",17255729,0.463900420716114,46194581774.0476,2677.05767597808,1287.91683953808,1932.33985799653,173405973.100478,10.0491826859635,12.0965412922095,11.1467707734152,67.0707733711292,0.00239188892889963,28040.9230381716,27281.0781644868,52.5311380961211 +"S1NoCDAvg",74388586,1,138822291283.827,1866.17730956503,0,1866.17730956503,829028733.525985,11.144569054263,0,11.144569054263,0,0,NA,NA,0 +"S1a",74386318,1,152526962184.78,2050.47065489624,0,2050.47065489624,829711078.011919,11.154081830101,0,11.154081830101,184.29334533121,0.00951277583801158,19373.2458821117,19819.9795016984,291.345446569379 +"S1b",74385413,1,148706489800.896,1999.13509656652,0,1999.13509656652,829367943.822646,11.1496046116279,0,11.1496046116279,132.957787001493,0.00503555736485772,26403.787578587,27712.0202056701,118.820081241429 +"S1c",74390720,1,149630762735.017,2011.41705222126,0,2011.41705222126,829312432.582254,11.1480629920271,0,11.1480629920271,145.23974265623,0.00349393776411056,41569.069760807,44912.9866634021,29.4571455493569 +"S2NoCD",44157029,0.593599520765188,102687192587.025,2325.50049023961,1195.27746112455,1866.17730956503,481821542.857639,10.9115480314049,11.4849258563939,11.144569054263,0,0,NA,NA,0 +"S2a",44154576,0.59356654527618,108994087698.382,2468.46640987747,1195.27746112455,1950.99982691963,482147541.414379,10.919537341144,11.4849258563939,11.1493301486582,84.8225173546048,0.00476109439511951,17815.7604775814,17894.6522675052,153.232202401385 +"S3NoCD",34491937,0.463672437596811,87288548274.2129,2530.69429745894,1291.68098828586,1866.17730956503,346433081.148818,10.0438859420629,12.0961450265451,11.144569054263,0,0,NA,NA,0 +"S3a",34494037,0.46370066773416,91012637189.7398,2638.50349524875,1291.68098828586,1916.20348408395,346595429.487732,10.0479810318442,12.0961450265451,11.1464100145732,50.0261745189171,0.00184096031021141,27173.9560279668,26326.4552295907,42.0218409916852 +"S3b",34509196,0.463904448997054,93844195380.3901,2719.39674805493,1291.68098828586,1954.00468114594,346989244.017051,10.0549790849097,12.0961450265451,11.1492390650792,87.8273715809078,0.00467001081617191,18806.6741252007,17010.7293488179,145.673169227783 +"S3c",34504471,0.463840931188019,92029481714.0825,2667.17555861333,1291.68098828586,1929.69167063061,346825426.841392,10.0516082927743,12.0961450265451,11.1478052041048,63.5143610655857,0.00323614984173659,19626.5204554009,17673.5383115466,98.2931310213171 +"S3d",34501231,0.463797376118965,92355832428.4109,2676.88513573359,1291.68098828586,1934.13503726122,346759010.739109,10.0506272004935,12.0961450265451,11.1474392260178,67.9577276961941,0.00287017175477366,23677.2338042721,21685.9863449855,75.5508600425674 diff --git a/reproduction/outputs/Sen7_3_Discountclinicalresults.csv b/reproduction/outputs/Sen7_3_Discountclinicalresults.csv index 78cba28..be4d1af 100644 --- a/reproduction/outputs/Sen7_3_Discountclinicalresults.csv +++ b/reproduction/outputs/Sen7_3_Discountclinicalresults.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,0.400733319767278,0.0756570523768302,0.12787617648766,0.0110773590734583,0.842396438441783,0.046107470726434,0.0491632764596596,0.0110600304517264,0.00193027101638251,0.464626221589564 -"S1b",1,1,1,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,0.405990262060088,0.0763712808406,0.128937839397539,0.0111722226350007,0.842428092026923,0.0461200603625631,0.0491383508538841,0.0110450824446697,0.0019243970545918,0.334053051708208 -"S1c",1,1,1,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,0.407947954891178,0.0766530888642384,0.129489210724663,0.0112076760636524,0.842538166986253,0.0460584214654526,0.0491005034611762,0.0110279779725777,0.00192817614834111,0.288617682950729 -"S2NoCD",0.593556763930821,0.582309685946903,0.705357761730891,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535928947491,0.582469204763036,0.706205579755609,0.0223350819017627,0.146861435551105,0.229046748962462,0.0868671748983432,0.40717154949026,0.0764348498798735,0.129245718868216,0.0111517123369551,0.842521478413868,0.0460676071299697,0.0490956905759404,0.0110472695587943,0.00192542928407099,0.310401264733618 -"S3NoCD",0.463572330217334,0.415367575216711,0.586199735331415,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463627818482614,0.415521682993537,0.587418330972747,0.020135761944108,0.139262558345173,0.180514922789748,0.0822286518533507,0.41091282114974,0.0771068690707244,0.130110991228192,0.0112307468065051,0.842479359257107,0.0461006199327869,0.0491419221040822,0.0110143369803305,0.00191704201835805,0.230684563840532 -"S3b",0.463695135641656,0.415568309564907,0.587233190193687,0.022688346451263,0.146674288242097,0.23269825950894,0.087000110491251,0.406420061933482,0.0764673667010533,0.129141145874287,0.0111893784669518,0.842504903342492,0.0460727197764389,0.0491258682896983,0.011035402357133,0.00191563803310912,0.31741923502635 -"S3c",0.463734789319606,0.415536541294178,0.58767782317134,0.0213351323942394,0.142951005888522,0.207202321894185,0.0845726197929377,0.408416061307295,0.0768438830632355,0.129544969634437,0.0111987434083334,0.842454283191634,0.0461336208713429,0.049131868036605,0.0110135739715596,0.00192049474425886,0.273951977879277 -"S3d",0.463756430818419,0.415604987692288,0.587558132403041,0.0207663794232776,0.141381171887563,0.195210605479162,0.0835996238319034,0.409497721665754,0.0769666360150598,0.129714362011153,0.0112324729853736,0.842472623948323,0.0461088404884722,0.0491357216371956,0.0110219486609554,0.00191644348636688,0.254304413340487 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,0.400846084529803,0.0756315299990488,0.127733286815624,0.011087348090606,0.842364170321789,0.046129034765383,0.0491766451495284,0.011049622312511,0.00193589729339196,0.464833027470088 +"S1b",1,1,1,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,0.405907939424458,0.0764086574377509,0.129012461230401,0.0111605841676993,0.842479484739466,0.0460932357315975,0.0491198733047791,0.0110443784905514,0.00192158664025428,0.334294602837872 +"S1c",1,1,1,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,0.407967793915124,0.0766466687883462,0.129330321903309,0.0111360755262005,0.842511866298224,0.0461015049376835,0.0491018031400455,0.0110240858181335,0.00191735547661239,0.288407573923277 +"S2NoCD",0.593591118938596,0.582365621911992,0.705116455867408,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.593703622757395,0.582561633495118,0.706249983323194,0.0223572293275455,0.146520275764833,0.228783458335563,0.0867962070990575,0.406907175011621,0.0764857628938958,0.129161959754734,0.0111849702484567,0.842453436358219,0.0460995130135702,0.049162136254093,0.0110232564059888,0.00191909420686546,0.310203001792548 +"S3NoCD",0.46378531781744,0.415568056211066,0.586617239472126,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.463880507151998,0.415699320053362,0.586708781881545,0.0201156015599614,0.139591817454275,0.180822991967125,0.0824771154683174,0.410893918376555,0.0771596359153628,0.13002154727965,0.0112567726274374,0.842566021780609,0.0460728067506646,0.0490891975121309,0.0110179222026286,0.00191286787636638,0.231194614752874 +"S3b",0.463774630694015,0.415673744808273,0.587660544823951,0.022703218559012,0.147101677876022,0.233250693892965,0.0873282101842993,0.406897958993362,0.0765657243606348,0.12916424164248,0.0111938516834175,0.84245733212396,0.0460718832826625,0.0491420777172941,0.0110558113255998,0.00192827941971036,0.318156004167639 +"S3c",0.463731546127251,0.415538305063213,0.587311603486886,0.0213261904240776,0.143268049986543,0.207485881195491,0.0848645010202161,0.409017522509301,0.0768424095578439,0.12956240035588,0.0112182155362607,0.842485614704402,0.0460621493958521,0.0491521297235465,0.0110349049383035,0.00192076633511325,0.274243522611208 +"S3d",0.463883854439712,0.415752092299157,0.587221087548919,0.0207546147301295,0.141567271736428,0.195481611880112,0.0837050652172602,0.40984416843231,0.0769796311184294,0.1297896347637,0.0112424293950455,0.842510845247546,0.0460587342353947,0.0491389891816906,0.0110270863763496,0.00192123076545521,0.254532916078862 diff --git a/reproduction/outputs/Sen7_3_Discountclinicalresults_5y.csv b/reproduction/outputs/Sen7_3_Discountclinicalresults_5y.csv index fc6208a..2a670bd 100644 --- a/reproduction/outputs/Sen7_3_Discountclinicalresults_5y.csv +++ b/reproduction/outputs/Sen7_3_Discountclinicalresults_5y.csv @@ -1,12 +1,12 @@ "Scenario","PropAgents","ProppPatientYears","ProppCopdPYs","SABAAll","LAMAAll","LAMALABAAll","ICSLAMALABAAll","MildpAgentAll","ModeratepAgentAll","SeverepAgentAll","VerySeverepAgentAll","NoCOPDpPYAll","GOLD1pPYAll","GOLD2pPYAll","GOLD3pPYAll","GOLD4pPYAll","DiagnosedpPYAll" -"S1NoCDAvg",1,1,1,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S1a",1,1,1,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,0.403047226128249,0.0760263148853383,0.12840956363145,0.0111267149068236,0.842461254812893,0.0461118957155039,0.049118855485952,0.0110334546540076,0.00192729365384067,0.399988053390932 -"S1b",1,1,1,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,0.408631980264935,0.0767122278432579,0.129370859426918,0.0112158820542419,0.8424572166305,0.0461045345921089,0.0491178381114376,0.0110465138362427,0.00192862473289225,0.294526778968184 -"S1c",1,1,1,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,0.409231958715491,0.0769956856216946,0.129978355787239,0.0112124528453459,0.842487284544981,0.0461078639931604,0.0491352633754891,0.0110153793798817,0.00191157483979592,0.26029455677229 -"S2NoCD",0.593443287202261,0.582273174807522,0.705545677347615,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S2a",0.593535633225147,0.582295847461883,0.706034831690326,0.0214260856128922,0.143399662052018,0.208913322432459,0.0847853184386878,0.407655221861622,0.0767470760900907,0.129218216541159,0.011199194631369,0.842544394644732,0.046094763613817,0.0491127745862289,0.0109897656237673,0.00191086601779681,0.277612135628334 -"S3NoCD",0.463868670889904,0.415635368247289,0.587073562742789,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,0.413782863019206,0.0774553947202378,0.130389223834769,0.0112632844525806,0.842599638409618,0.046091766851725,0.0490657802834767,0.0109902872013995,0.00190873515974956,0.186007135168575 -"S3a",0.463789632372499,0.415622940758265,0.586809647097927,0.0197696669249095,0.138028597361208,0.171429592848262,0.081236444450917,0.411287856148879,0.07722846001244,0.130038331526943,0.0112026643175846,0.842626066479021,0.0461014349785822,0.0490229859734682,0.0109954420436182,0.00190926922852537,0.216839145396673 -"S3b",0.463662364229167,0.415627753354033,0.587309552953142,0.0217273072426316,0.144075656740584,0.212315561616708,0.085323826327292,0.407654369789789,0.0766217806454282,0.129340579136661,0.0111730977587919,0.84257351681126,0.0461000010925949,0.0490636336910152,0.0110096977534996,0.00191076692651309,0.284092335789576 -"S3c",0.463642228225923,0.415569605134916,0.587621281450251,0.0206710534473348,0.140931536559447,0.191763032350927,0.08324285525963,0.409917216243935,0.07702129939584,0.12970969386912,0.0111986612734943,0.842538118936641,0.0460823834781866,0.0491061374122304,0.0110204077894173,0.00191447077751689,0.249320504213185 -"S3d",0.463900420716114,0.415712328288473,0.587409792818855,0.0202416660684579,0.139590000283801,0.18228853527996,0.0822922365025336,0.410444613492492,0.077025066408215,0.129808877075041,0.0112098048644388,0.842570046688464,0.0461323938488098,0.0490485515602565,0.0110024025072699,0.00190357830414835,0.234231338952332 +"S1NoCDAvg",1,1,1,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S1a",1,1,1,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,0.403687247969445,0.076043339045226,0.128491882068958,0.0111234434267872,0.842404538075766,0.0461249975109299,0.0491350481006971,0.0110626268806794,0.00192774403765099,0.400376813672669 +"S1b",1,1,1,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,0.408261469221123,0.0767148930126932,0.12942550981064,0.0111918986051741,0.842444102006296,0.0461405534347918,0.049119839074542,0.0110326731874807,0.0019206407489528,0.294383825212184 +"S1c",1,1,1,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,0.409414400075708,0.0768280371530212,0.129676147777572,0.0111990850471672,0.842566279080345,0.0460770376386533,0.0490825292231934,0.0110175512447196,0.00191369725957158,0.260088914224771 +"S2NoCD",0.593599520765188,0.582336120728919,0.705468838282451,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S2a",0.59356654527618,0.582414633463478,0.70594630719989,0.0213965559374253,0.143850474561616,0.209480412096954,0.0850850980302915,0.408667539118558,0.0767385183547775,0.129416522072223,0.0112172729297281,0.842512558981358,0.0461063547945422,0.0490973671326712,0.0110198437844154,0.00191734574481944,0.277927102442024 +"S3NoCD",0.463672437596811,0.415434005363706,0.586089346363954,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,0.414111621909307,0.0774707224573404,0.130409899174586,0.0112712251312318,0.842560505721972,0.0460766506618468,0.0491056269425201,0.0110052752811752,0.00190817099901409,0.186144586802432 +"S3a",0.46370066773416,0.415527713942897,0.586531096227929,0.0197899392090461,0.138303277630978,0.171711091371148,0.0814794148216474,0.412123358096292,0.0772548393515772,0.130128312756924,0.0112117859678794,0.842519910814925,0.0460735235689768,0.0491516810272371,0.0110056311963728,0.00190514377766393,0.217315925410359 +"S3b",0.463904448997054,0.415785735654782,0.587675158368244,0.0217415888048102,0.144179021361847,0.212418250542373,0.0853294076058373,0.409418571728946,0.0768062462692041,0.129433160211189,0.0111817841277405,0.842414303912108,0.0460965101654088,0.0491882510131361,0.0110409375550577,0.00191758449244497,0.28441849116625 +"S3c",0.463840931188019,0.415695058927611,0.586925015622923,0.0206753702957292,0.141063374890625,0.191706805465128,0.0833410596328628,0.410579318361524,0.076984479764633,0.129710841719411,0.0112076528740334,0.842489353520781,0.0460832909926345,0.0491418310503537,0.0110238974057143,0.0019169509018325,0.24963076915198 +"S3d",0.463797376118965,0.41566768511288,0.586881023447397,0.02025846993191,0.139712240331005,0.182490438501157,0.0824624734254074,0.411214425863804,0.0771279852307872,0.129855466070449,0.0112227977270353,0.842491682442217,0.0460936959542376,0.0491366016280874,0.011022918093246,0.00191137314896782,0.234585140125143 diff --git a/reproduction/outputs/Sen7_3_Discounts1.csv b/reproduction/outputs/Sen7_3_Discounts1.csv index 6348ebb..2f2937a 100644 --- a/reproduction/outputs/Sen7_3_Discounts1.csv +++ b/reproduction/outputs/Sen7_3_Discounts1.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,69325010795.5079,1863.75161340531,414511484.695074,11.1438345196123,555327.974367207,0,0,NA,0 -"S1NoCD2",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,69440018935.1755,1866.78645931692,414564641.630319,11.1449229331218,555379.360196773,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,69382514865.3417,1865.2690595526,414538063.162696,11.1443787346844,555353.66728199,0,0,NA,0 -"S1a",37195779,626218800.231142,71281372.3281143,186100281,33119194.6945306,13388772,0.0264129670304063,0.159435537704009,0.310049787431074,0.0943011814813817,14905588,2814123,4756454,412031,0.209109161526637,0.0394790799908614,0.0667278679499271,0.0057803460643741,527524487,28873365,30786968,6925999,1208772,78988588612.6422,2123.59011522899,415048182.916947,11.1584753451984,555800.177144689,259.838501823687,0.014640825586115,17747.5307178108,472.202777481987 -"S1b",37200476,626144171.819881,71252444.7802286,188422793,23802096.6205059,13372758,0.0216055253670271,0.148060357940042,0.240495980498854,0.0875940938594751,15103031,2841048,4796549,415612,0.211965091816623,0.0398729897446037,0.067317676113353,0.00583295073287542,527481440,28877807,30767692,6915814,1204950,76461197768.4769,2055.38224211101,414832041.59623,11.1512562795226,555507.43173402,191.630628705706,0.00742175991035943,25820.1061500554,179.457366812276 -"S1c",37192813,625960445.075725,71159107.171146,189176712,20537776.6325788,13372239,0.0201493499699737,0.144241287100822,0.214385540584314,0.085209295309033,15172732,2850944,4816068,416845,0.213222630288317,0.0400643587776213,0.0676802758137028,0.0058579290349644,527395566,28830750,30734973,6903078,1206962,77318972105.8953,2078.86862727741,414653652.849152,11.1487574991747,555359.006331458,215.117013872101,0.00492297956244947,43696.5076013981,31.0319642502582 +"S1NoCD",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,138701936800.849,1864.55535809534,829008490.357008,11.1442728072434,555349.085004074,0,0,NA,0 +"S1NoCD2",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,138942645766.805,1867.79926805554,829048976.694961,11.144865302565,555375.465860196,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,138822291283.827,1866.17730956503,829028733.525985,11.144569054263,555362.275432135,0,0,NA,0 +"S1a",74380275,1252107231.24309,142568770.421589,372100831,66270673.1777553,26745802,0.0264033138925038,0.159301806617728,0.309994647139887,0.0940913632177455,29815042,5625494,9500837,824680,0.209127440124749,0.0394581084157834,0.0666403797402835,0.00578443650430136,1054730269,57758498,61574433,13835312,2423951,157886317266.186,2122.6906900544,829882712.533117,11.1572955670454,555742.087662215,258.135331959055,0.0130227598019985,19821.8607947787,393.002658140846 +"S1b",74383024,1252030977.73496,142410669.767258,376764647,47607118.2897207,26748888,0.0216397994557794,0.148234153545285,0.240652126036194,0.087794730719482,30192660,5683507,9596337,830158,0.212011221134933,0.0399092779304288,0.0673849579928479,0.00582932445551117,1054810413,57710159,61499603,13827904,2405886,152914677120.41,2055.77387012942,829494032.024955,11.1516578302188,555527.117640812,191.218512034078,0.0073850229754342,25892.7443652044,178.032636737684 +"S1c",74393892,1252166866.96087,142379317.946113,378416895,41063273.6656893,26758496,0.0201516811202333,0.144110984990596,0.214191162065294,0.0851719901555341,30350312,5702044,9621386,828456,0.213165173410135,0.0400482603952217,0.0675757275620708,0.00581865408509366,1054965444,57726777,61483651,13803995,2400849,154475292878.787,2076.4512882158,829462689.506534,11.1496074100618,555403.919214872,211.89593012046,0.00533460281836362,39721.0321621392,54.8342107976787 diff --git a/reproduction/outputs/Sen7_3_Discounts1_5y.csv b/reproduction/outputs/Sen7_3_Discounts1_5y.csv index c907920..d46cff5 100644 --- a/reproduction/outputs/Sen7_3_Discounts1_5y.csv +++ b/reproduction/outputs/Sen7_3_Discounts1_5y.csv @@ -1,7 +1,7 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S1NoCD2",37196486,625953635.838479,71118020.8847579,190966216,13166456.1704389,13371458,0.0171523229869794,0.135457495761723,0.151286050897898,0.0796452013453249,15396892,2883299,4850541,419077,0.216497756946157,0.0405424527304015,0.068204105508785,0.00589269772677008,527427474,28845970,30727603,6872520,1191666,69325010795.5079,1863.75161340531,414511484.695074,11.1438345196123,555327.974367207,0,0,NA,0 -"S1NoCD",37197623,626035665.974114,71126459.5446315,124680042,13292032.1277742,16339249,0.0208652359262356,0.135486046438232,0.15129433978913,0.0795589532302743,15386115,2878926,4849649,418845,0.21632055213356,0.0404761606079027,0.0681834725227237,0.00588873680317487,527498259,28860429,30702229,6887202,1198050,69440018935.1755,1866.78645931692,414564641.630319,11.1449229331218,555379.360196773,0,0,NA,0 -"S1NoCDAvg",37197054,625994650.906296,71122240.2146947,157823129,13229244.1491066,14855353.5,0.0190087794566075,0.135471771099978,0.151290195343514,0.0796020772877996,15391503.5,2881112.5,4850095,418961,0.216409154539858,0.0405093066691521,0.0681937890157543,0.00589071726497248,527462866.5,28853199.5,30714916,6879861,1194858,69382514865.3417,1865.2690595526,414538063.162696,11.1443787346844,555353.66728199,0,0,NA,0 -"S1a",37197502,626089852.781592,71222083.952196,122776626,28487982.7184844,16327137,0.027780056749288,0.154140998252729,0.273217272186502,0.0911565534267491,14992350,2827989,4776515,413886,0.210501422705671,0.0397066309081624,0.0670650833975313,0.00581120316948039,527456443,28870190,30752817,6907934,1206659,76233049354.3059,2049.41313947119,414888345.892525,11.1536614983588,555633.66177847,182.626680154273,0.00873856523702443,20898.9319414247,254.301581696956 -"S1b",37190655,625992698.014129,71214502.2789584,123717512,20974577.9720441,16327973,0.024055343673977,0.144780213608532,0.215751485560705,0.085624747115764,15197291,2852978,4811387,417126,0.213401631882082,0.0400617558039574,0.0675618988552786,0.00585731819575248,527372066,28861102,30747408,6915037,1207305,74352383548.6806,1999.22221183468,414673206.381945,11.149930174178,555497.286497067,132.435752517767,0.00500724105623718,26448.8469858668,117.926300293999 -"S1c",37195162,626110981.941873,71210037.1648892,124047387,18535585.0615731,16324587,0.0229349137974298,0.142216288837683,0.196258740261527,0.0839633650967104,15221449,2863867,4834566,417049,0.213754262826099,0.0402171816505112,0.0678916370848874,0.00585660416149354,527490541,28868640,30764128,6896850,1196858,74927136725.5007,2014.43232658862,414704948.175006,11.1494325034801,555457.192847414,147.645867271706,0.00450957035826782,32740.5618588505,77.8326506416779 +"S1NoCD2",74388747,1251903575.56793,142277085.797618,381929878,26336152.9722467,26747209,0.0171603650674267,0.135420487445155,0.151258231995981,0.0796367741476374,30809289,5766720,9701609,839538,0.216544279265213,0.0405316145440516,0.0681881340597605,0.00590072530157247,1054811684,57697202,61465410,13763906,2389153,138701936800.849,1864.55535809534,829008490.357008,11.1442728072434,555349.085004074,0,0,NA,0 +"S1NoCD",74388425,1251968458.15893,142302174.709773,249329256,26636735.8874433,32661650,0.0208505310510112,0.1356299321073,0.151483376607954,0.0796998730784238,30801067,5759155,9700407,837363,0.216448322471663,0.040471307003887,0.0681676651799881,0.00588440058423429,1054852003,57672835,61488796,13791895,2388663,138942645766.805,1867.79926805554,829048976.694961,11.144865302565,555375.465860196,0,0,NA,0 +"S1NoCDAvg",74388586,1251936016.86343,142289630.253695,315629567,26486444.429845,29704429.5,0.0190054480592189,0.135525209776227,0.151370804301967,0.0796683236130306,30805178,5762937.5,9701008,838450.5,0.216496300868438,0.0405014607739693,0.0681778996198743,0.00589256294290338,1054831843.5,57685018.5,61477103,13777900.5,2388908,138822291283.827,1866.17730956503,829028733.525985,11.144569054263,555362.275432135,0,0,NA,0 +"S1a",74386318,1252092577.05249,142511621.315835,245523949,57058348.8537602,32655914,0.0277769936975265,0.154167641188159,0.273572462100913,0.0911068073884312,30028808,5656584,9558038,827432,0.210711293035183,0.0396920893031161,0.0670684812350664,0.00580606684816418,1054768469,57752767,61521629,13851433,2413714,152526962184.78,2050.47065489624,829711078.011919,11.154081830101,555653.620850156,182.671386840696,0.00921652753601698,19819.9795016984,278.154989960138 +"S1b",74385413,1252007175.89227,142455061.307373,247448362,41936465.8685008,32651747,0.0240246475362399,0.144918411126393,0.215990836271363,0.0856255611013939,30368698,5706469,9627370,832514,0.213180898743035,0.0400580291611207,0.0675818037747859,0.0058440464828673,1054746061,57768304,61498391,13812986,2404656,148706489800.896,1999.13509656652,829367943.822646,11.1496046116279,555481.095484828,131.335828510979,0.00473930906286313,27712.0202056701,105.629624632187 +"S1c",74390720,1252048090.68724,142295860.364143,248074520,37009575.8207896,32668233,0.0229386696848866,0.141901113072544,0.195911935708657,0.0838224210413279,30456632,5715293,9646702,833108,0.214037372008291,0.0401648578207,0.0677932722379522,0.00585475921694439,1054933501,57690667,61453687,13794504,2396041,149630762735.017,2011.41705222126,829312432.582254,11.1480629920271,555391.732549136,143.617784165716,0.00319768946211596,44912.9866634021,16.2666889401153 diff --git a/reproduction/outputs/Sen7_3_Discounts2.csv b/reproduction/outputs/Sen7_3_Discounts2.csv index ffec94b..36f4c68 100644 --- a/reproduction/outputs/Sen7_3_Discounts2.csv +++ b/reproduction/outputs/Sen7_3_Discounts2.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22078563,364522748.573687,50166624.1671238,110968095,9653605.82348446,7738507,0.0172779795723912,0.141222462720366,0.158929640922804,0.0870932535738703,11438971,2125413,3543389,304919,0.228019548652357,0.0423670724368348,0.0706323987078669,0.00607812475051542,298790021,18633807,22502661,5543543,1025792,51195392088.1397,2318.78279796288,240914015.067657,10.9116709754913,543264.765976604,0,0,NA,0 -"S2a",22077788,364622606.499305,50226922.8843361,108797477,18511083.7047635,7734136,0.0229898067769556,0.157327004308664,0.269003214018226,0.0973502415391329,11192847,2087413,3500787,300763,0.22284556483333,0.041559643317329,0.0696994121670902,0.00598808333714978,298828425,18622586,22524521,5579724,1036307,55740228536.7613,2524.71980149285,241147117.181689,10.9226122282581,543605.89161141,205.937003529974,0.0109412527667185,18822.0679953945,341.125634805998 +"S2NoCD",44156404,729084497.054691,100330759.79117,221928932,19330951.6588092,15481473,0.0172596709453046,0.141645486548806,0.159259990701265,0.08725337635747,22917076,4253860,7098458,609501,0.228415254182267,0.0423983632622146,0.070750565577046,0.00607491661847899,597619551,37246010,44990133,11123560,2050468,102511836117.178,2321.56214797695,481847557.683567,10.9122916278139,543293.019242717,0,0,NA,0 +"S2a",44164773,729329891.015329,100492048.993736,217625447,37010683.2532179,15485858,0.0230145995823502,0.157180410449991,0.268827891528291,0.0973046709934024,22383331,4181008,7006346,603148,0.222737333193348,0.0416053612386849,0.0697204014661571,0.00600194747783078,597700094,37284225,45068617,11147317,2064302,111527223359.312,2525.25295124493,482358788.680347,10.9217993417593,543564.714136718,203.690803267972,0.00950771394538741,21423.741231381,271.69489400147 diff --git a/reproduction/outputs/Sen7_3_Discounts2_5y.csv b/reproduction/outputs/Sen7_3_Discounts2_5y.csv index 2b3f92f..a93e329 100644 --- a/reproduction/outputs/Sen7_3_Discounts2_5y.csv +++ b/reproduction/outputs/Sen7_3_Discounts2_5y.csv @@ -1,3 +1,3 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S2NoCD",22074342,364499892.795735,50179989.1467565,72492409,9769650.24862608,9434235,0.0208917555301636,0.141988942022567,0.159733364688847,0.0874666663868567,11472370,2126666,3551252,304704,0.228624401779918,0.0423807584688858,0.070770282345299,0.00607222132130921,298757005,18626945,22501053,5562438,1027303,51361753549.0855,2326.76260742384,240891915.913164,10.9127563536509,543311.055075123,0,0,NA,0 -"S2a",22077777,364514085.756087,50214778.8994209,71673455,16290550.2537317,9435494,0.0250429167756047,0.153202361136407,0.241328632393267,0.094789501013715,11245330,2100490,3507989,302346,0.223944628383691,0.0418301154767053,0.0698596922437202,0.00602105608401846,298734836,18629376,22530917,5562183,1028646,54432158311.1104,2465.47278338351,241039404.019419,10.9177388656212,543421.470497679,138.710175959672,0.00498251197031863,27839.4064652496,110.415422556223 +"S2NoCD",44157029,729047563.461063,100380900.154714,145000421,19524492.074223,18863743,0.0209029627109113,0.141781753914197,0.159519185673724,0.0873704363140082,22925265,4254784,7099566,609563,0.228382739790797,0.0423863901742486,0.0707262635527043,0.00607249983871931,597538799,37245010,45040554,11117169,2054803,102687192587.025,2325.50049023961,481821542.857639,10.9115480314049,543251.901080006,0,0,NA,0 +"S2a",44154576,729145856.381239,100448839.030434,143361789,32595478.4145126,18878233,0.0250078581664384,0.153560443203067,0.241814960491553,0.0950258179639202,22519648,4200194,7025459,605531,0.224190226759883,0.0418142612751096,0.0699406689794734,0.00602825284836329,597564735,37286040,45033303,11135908,2066352,108994087698.382,2468.46640987747,482147541.414379,10.919537341144,543508.400647321,142.965919637863,0.00798930973905954,17894.6522675052,256.499567315099 diff --git a/reproduction/outputs/Sen7_3_Discounts3.csv b/reproduction/outputs/Sen7_3_Discounts3.csv index c810f1a..9f4facb 100644 --- a/reproduction/outputs/Sen7_3_Discounts3.csv +++ b/reproduction/outputs/Sen7_3_Discounts3.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17243525,260017880.24558,41691838.3900313,80059027,7819384.14256,5815322,0.0183575174217772,0.137156256672018,0.154366597029931,0.0863650846874626,9754415,1816466,3038101,261338,0.233964616977224,0.043568863119126,0.0728704014339272,0.00626832517086814,207433146,15294590,18682841,4808648,895345,43585079096.4942,2527.62002528452,173193983.206107,10.0440010500235,499672.432475891,0,0,NA,0 -"S3a",17245589,260114350.889536,41778507.6419587,79305268,11012874.3912697,5816924,0.0210701415875502,0.143601112787989,0.204102307078173,0.090802566674972,9648241,1803612,3027939,260144,0.230937904309204,0.0431708096291264,0.0724759971310943,0.00622674228168777,207442211,15303706,18733677,4824249,900624,46423704300.026,2691.91758542001,173312928.019824,10.0496960712576,499792.885977462,164.297560135495,0.00569502123413557,28849.3323169204,120.453501571319 -"S3b",17248093,260143538.873804,41765340.0149969,77789956,17179218.0534133,5809490,0.0272123567386269,0.156225870536493,0.292983388954392,0.0989344402695251,9481831,1779958,2992091,258625,0.227026309293671,0.0426180655864614,0.0716405277420372,0.00619233555639998,207483725,15287322,18724587,4837601,899769,48252461324.4413,2797.5534063065,173460430.655696,10.0567889247638,500041.892831884,269.93338102198,0.0127878747402992,21108.541216104,369.460355993011 -"S3c",17249568,260123652.106259,41796963.3084409,78552778,14093542.3037528,5811921,0.0239564020668036,0.149872778444183,0.249488678363603,0.0947819160826065,9556493,1794042,3007246,258985,0.228640844778072,0.0429227833314315,0.0719489111639047,0.00619626354404789,207434647,15324709,18727689,4823824,902793,47056539449.2717,2727.98364859176,173385532.23841,10.0515869289254,499851.362797678,200.363623307239,0.00758587890187457,26412.7104978867,178.930321786494 -"S3d",17250373,260166499.185349,41788450.6328664,78909896,12694598.7095123,5812281,0.0225871693478081,0.14720440466007,0.229100157335109,0.0931309605323503,9596955,1798651,3013620,260246,0.229655678893537,0.0430418207126676,0.0721160979734865,0.00622770157923294,207483596,15310784,18731510,4829309,900292,47356022542.0812,2745.21730875508,173385479.345343,10.0511147988129,499810.522631891,217.597283470555,0.00711374878941484,30588.2720787578,138.090156000166 +"S3NoCD",34500334,520264617.028559,83469550.1049324,160191877,15617539.1621454,11630123,0.018371612334161,0.136660912007116,0.153889981724535,0.0860423303941354,19525292,3631989,6073558,522424,0.23392113621619,0.0435127420171081,0.0727637562723739,0.00625885726403513,415002016,30608834,37422882,9624470,1788687,87147515107.9228,2525.99047614794,346536201.74847,10.0444303451807,499695.526782887,0,0,NA,0 +"S3a",34507415,520428950.960441,83482575.6405212,158676520,22030097.8695766,11639538,0.0210425232718254,0.143591703407669,0.204088019848658,0.0908272943093332,19287934,3609226,6045313,521405,0.231041434119792,0.043233285177274,0.072414069087079,0.00624567457340066,415152628,30610103,37407716,9641236,1794702,92759974975.707,2688.11717643025,346780019.65528,10.0494348723392,499783.626440529,162.126700282318,0.00500452715847644,32396.0076843055,88.0996576414909 +"S3b",34499539,520396932.389974,83618001.6376853,155590263,34428826.1327912,11625591,0.0272677362023387,0.156355277894248,0.293211112522871,0.0990494988470827,18988453,3564625,5980823,516662,0.227085706762959,0.0426298755074946,0.0715255433383203,0.00617883697147755,414988556,30607762,37472866,9688489,1813970,96533122890.8993,2798.09892215949,346983955.051516,10.0576403369192,500083.917923798,272.108446011553,0.0132099917384494,20598.684041531,388.391140910913 +"S3c",34496334,520227370.495019,83568350.903854,157099275,28171360.7955484,11622564,0.0239564406652199,0.14984119401007,0.249428440470547,0.0948714951513754,19145218,3585036,6010150,518449,0.229096515522087,0.0428994465156386,0.0719189733313599,0.00620389171728995,414875686,30589301,37479876,9661353,1804425,94096368027.4299,2727.72080730172,346758703.786504,10.052045060397,499874.532212547,201.730331153788,0.00761471521627399,26492.1701500608,179.005429659912 +"S3d",34507664,520495018.435642,83555471.4245087,157877292,25364365.9811382,11630839,0.0225793272116635,0.14694733242596,0.229001602594022,0.0929007877476101,19209915,3595849,6028084,520340,0.229906129095997,0.0430354701935804,0.0721446949820192,0.00622747967462694,415141325,30594930,37472224,9653084,1805226,94690116841.6979,2744.03149519764,346877136.052445,10.0521767005858,499864.803534094,218.041019049706,0.00774635540513202,28147.5620012545,169.276751206897 diff --git a/reproduction/outputs/Sen7_3_Discounts3_5y.csv b/reproduction/outputs/Sen7_3_Discounts3_5y.csv index 517b968..074c72e 100644 --- a/reproduction/outputs/Sen7_3_Discounts3_5y.csv +++ b/reproduction/outputs/Sen7_3_Discounts3_5y.csv @@ -1,6 +1,6 @@ "Scenario","Agents","PatientYears","CopdPYs","NCaseDetections","DiagnosedPYs","OverdiagnosedPYs","SABA","LAMA","LAMALABA","ICSLAMALABA","Mild","Moderate","Severe","VerySevere","MildPY","ModeratePY","SeverePY","VerySeverePY","NoCOPD","GOLD1","GOLD2","GOLD3","GOLD4","Cost","CostpAgent","QALY","QALYpAgent","NMB","IncrementalCosts","IncrementalQALY","ICER","IncrementalNMB" -"S3NoCD",17254548,260185517.250271,41753986.9530892,52456874,7922835.39457538,7061036,0.0221592886073816,0.13726133321656,0.154573171523665,0.0864947424330528,9767617,1818208,3040076,262205,0.233932558607492,0.043545733777298,0.0728092386342779,0.00627975959025394,207533583,15301679,18724752,4815426,897482,43698225565.3525,2532.56275188156,173302715.863562,10.0438861605393,499661.745275085,0,0,NA,0 -"S3a",17251608,260177737.708618,41735216.681199,52193377,10112285.5219638,7056308,0.0239901655742498,0.141620447019917,0.188896901320193,0.0892874240346538,9673981,1809610,3026757,259927,0.23179419610772,0.0433593052558704,0.0725228533763311,0.00622800168944835,207543323,15307443,18697708,4818609,897810,45514928489.8059,2638.30064361571,173345067.882346,10.0480527891862,499764.338815692,105.73789173415,0.00416662864683381,25377.3255781984,102.593540607544 -"S3b",17246874,260180750.367826,41770771.1055183,51592135,14901907.2426103,7060341,0.0287001627876402,0.151909252445312,0.258476623670136,0.0962303406481393,9537491,1786791,3000373,258790,0.228329301748035,0.0427761076156898,0.0718294855611038,0.00619548055137079,207513062,15306657,18723252,4827550,898750,46894607074.7492,2719.02068019684,173436965.103661,10.0561391649096,500087.937565284,186.457928315283,0.0122530043702795,15217.323252373,426.192290198756 -"S3c",17246125,260144349.893699,41792941.9345714,51894923,12432862.6252413,7060467,0.0261601311174318,0.146548593395628,0.223441477763239,0.0926749735395,9621451,1801612,3014035,259735,0.23021712649621,0.0431080444832167,0.0721182778833468,0.00621480537088358,207459068,15294280,18748666,4834049,901039,46057749842.9718,2670.61440427759,173359596.803533,10.0520897768938,499933.874440414,138.051652396026,0.00820361635450695,16828.1458359742,272.12916532933 -"S3d",17255729,260233693.824386,41777900.3893267,52047317,11356969.6042882,7062160,0.0251240111093077,0.14426968081771,0.207339855216131,0.0910648854849654,9643777,1802264,3018596,260225,0.23083441030138,0.0431391712653046,0.0722534156065723,0.00622877161310102,207557193,15328896,18715546,4823282,894293,46194581774.0476,2677.05767597808,173405973.100478,10.0491826859635,499782.076622196,144.494924096523,0.00529652542415349,27281.0781644868,120.331347111147 +"S3NoCD",34491937,520096793.944658,83394436.3897572,104866546,15798843.6062051,14116443,0.0221440059305719,0.13704346682043,0.154368086406791,0.0863943143443837,19479590,3630576,6075819,523166,0.233583807784959,0.0435349905481935,0.0728564070102194,0.00627339211880875,414917152,30599570,37365292,9614469,1790750,87288548274.2129,2530.69429745894,346433081.148818,10.0438859420629,499663.602805684,0,0,NA,0 +"S3a",34494037,520214111.090036,83457292.8145667,104351592,20245608.2892442,14129448,0.0240307345372679,0.14177714164029,0.189041590205167,0.0894698764862355,19332282,3614629,6055063,518761,0.231642812126129,0.0433111221092604,0.0725528326620145,0.00621588578427331,414968911,30599997,37426814,9615582,1787056,91012637189.7398,2638.50349524875,346595429.487732,10.0479810318442,499760.548096962,107.809197789815,0.00409508978134809,26326.4552295907,96.9452912776032 +"S3b",34509196,520537137.764278,83620080.9934994,103218767,29823148.4264926,14132996,0.0287201148667908,0.151759070463881,0.258228121857447,0.0959834805484866,19135380,3582069,6004729,516649,0.228837137834004,0.0428374256212269,0.0718096530002979,0.00617852785911753,415119150,30640730,37483240,9661621,1802895,93844195380.3901,2719.39674805493,346989244.017051,10.0549790849097,500029.557497432,188.702450595989,0.0110931428468763,17010.7293488179,365.954691747786 +"S3c",34504471,520423616.303641,83513343.4596301,103824096,24853846.8628113,14121585,0.0261578150769642,0.14647414308412,0.223082059564315,0.0926287674905986,19220385,3595075,6024956,518536,0.23014747349076,0.0430479112806427,0.0721436329861758,0.00620901976281979,415113845,30619979,37421385,9639642,1802009,92029481714.0825,2667.17555861333,346825426.841392,10.0516082927743,499913.239080103,136.481261154393,0.00772235071147165,17673.5383115466,249.636274419143 +"S3d",34501231,520389346.039061,83507083.8292405,104079260,22711873.9482136,14135933,0.0251554674459531,0.144172895875718,0.20738377463961,0.0911334097630808,19266710,3605577,6035420,519637,0.230719468535119,0.0431768999067536,0.0722743475552509,0.00622266969665208,415086795,30631737,37413709,9638221,1794998,92355832428.4109,2676.88513573359,346759010.739109,10.0506272004935,499854.474888941,146.190838274653,0.00674125843062967,21685.9863449855,190.872083256836 diff --git a/reproduction/outputs/Sen7_3_Discountsall.csv b/reproduction/outputs/Sen7_3_Discountsall.csv index 9edb464..4f2ef5e 100644 --- a/reproduction/outputs/Sen7_3_Discountsall.csv +++ b/reproduction/outputs/Sen7_3_Discountsall.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S1a",37195779,78988588612.6422,2123.59011522899,415048182.916947,11.1584753451984,17747.5307178108,472.202777481987 -"S3b",17248093,48252461324.4413,2797.5534063065,173460430.655696,10.0567889247638,21108.541216104,369.460355993011 -"S2a",22077788,55740228536.7613,2524.71980149285,241147117.181689,10.9226122282581,18822.0679953945,341.125634805998 -"S1b",37200476,76461197768.4769,2055.38224211101,414832041.59623,11.1512562795226,25820.1061500554,179.457366812276 -"S3c",17249568,47056539449.2717,2727.98364859176,173385532.23841,10.0515869289254,26412.7104978867,178.930321786494 -"S3d",17250373,47356022542.0812,2745.21730875508,173385479.345343,10.0511147988129,30588.2720787578,138.090156000166 -"S3a",17245589,46423704300.026,2691.91758542001,173312928.019824,10.0496960712576,28849.3323169204,120.453501571319 -"S1c",37192813,77318972105.8953,2078.86862727741,414653652.849152,11.1487574991747,43696.5076013981,31.0319642502582 -"S1NoCD",37196486,69325010795.5079,1863.75161340531,414511484.695074,11.1438345196123,NA,0 -"S2NoCD",22078563,51195392088.1397,2318.78279796288,240914015.067657,10.9116709754913,NA,0 -"S3NoCD",17243525,43585079096.4942,2527.62002528452,173193983.206107,10.0440010500235,NA,0 +"S1a",74380275,157886317266.186,2122.6906900544,829882712.533117,11.1572955670454,19821.8607947787,393.002658140846 +"S3b",34499539,96533122890.8993,2798.09892215949,346983955.051516,10.0576403369192,20598.684041531,388.391140910913 +"S2a",44164773,111527223359.312,2525.25295124493,482358788.680347,10.9217993417593,21423.741231381,271.69489400147 +"S3c",34496334,94096368027.4299,2727.72080730172,346758703.786504,10.052045060397,26492.1701500608,179.005429659912 +"S1b",74383024,152914677120.41,2055.77387012942,829494032.024955,11.1516578302188,25892.7443652044,178.032636737684 +"S3d",34507664,94690116841.6979,2744.03149519764,346877136.052445,10.0521767005858,28147.5620012545,169.276751206897 +"S3a",34507415,92759974975.707,2688.11717643025,346780019.65528,10.0494348723392,32396.0076843055,88.0996576414909 +"S1c",74393892,154475292878.787,2076.4512882158,829462689.506534,11.1496074100618,39721.0321621392,54.8342107976787 +"S1NoCD",74388747,138701936800.849,1864.55535809534,829008490.357008,11.1442728072434,NA,0 +"S2NoCD",44156404,102511836117.178,2321.56214797695,481847557.683567,10.9122916278139,NA,0 +"S3NoCD",34500334,87147515107.9228,2525.99047614794,346536201.74847,10.0444303451807,NA,0 diff --git a/reproduction/outputs/Sen7_3_Discountsall_5y.csv b/reproduction/outputs/Sen7_3_Discountsall_5y.csv index 159e6a2..89a8a80 100644 --- a/reproduction/outputs/Sen7_3_Discountsall_5y.csv +++ b/reproduction/outputs/Sen7_3_Discountsall_5y.csv @@ -1,12 +1,12 @@ "Scenario","Agents","Cost","CostpAgent","QALY","QALYpAgent","ICER","IncrementalNMB" -"S3b",17246874,46894607074.7492,2719.02068019684,173436965.103661,10.0561391649096,15217.323252373,426.192290198756 -"S3c",17246125,46057749842.9718,2670.61440427759,173359596.803533,10.0520897768938,16828.1458359742,272.12916532933 -"S1a",37197502,76233049354.3059,2049.41313947119,414888345.892525,11.1536614983588,20898.9319414247,254.301581696956 -"S3d",17255729,46194581774.0476,2677.05767597808,173405973.100478,10.0491826859635,27281.0781644868,120.331347111147 -"S1b",37190655,74352383548.6806,1999.22221183468,414673206.381945,11.149930174178,26448.8469858668,117.926300293999 -"S2a",22077777,54432158311.1104,2465.47278338351,241039404.019419,10.9177388656212,27839.4064652496,110.415422556223 -"S3a",17251608,45514928489.8059,2638.30064361571,173345067.882346,10.0480527891862,25377.3255781984,102.593540607544 -"S1c",37195162,74927136725.5007,2014.43232658862,414704948.175006,11.1494325034801,32740.5618588505,77.8326506416779 -"S1NoCD",37197623,69440018935.1755,1866.78645931692,414564641.630319,11.1449229331218,NA,0 -"S2NoCD",22074342,51361753549.0855,2326.76260742384,240891915.913164,10.9127563536509,NA,0 -"S3NoCD",17254548,43698225565.3525,2532.56275188156,173302715.863562,10.0438861605393,NA,0 +"S3b",34509196,93844195380.3901,2719.39674805493,346989244.017051,10.0549790849097,17010.7293488179,365.954691747786 +"S1a",74386318,152526962184.78,2050.47065489624,829711078.011919,11.154081830101,19819.9795016984,278.154989960138 +"S2a",44154576,108994087698.382,2468.46640987747,482147541.414379,10.919537341144,17894.6522675052,256.499567315099 +"S3c",34504471,92029481714.0825,2667.17555861333,346825426.841392,10.0516082927743,17673.5383115466,249.636274419143 +"S3d",34501231,92355832428.4109,2676.88513573359,346759010.739109,10.0506272004935,21685.9863449855,190.872083256836 +"S1b",74385413,148706489800.896,1999.13509656652,829367943.822646,11.1496046116279,27712.0202056701,105.629624632187 +"S3a",34494037,91012637189.7398,2638.50349524875,346595429.487732,10.0479810318442,26326.4552295907,96.9452912776032 +"S1c",74390720,149630762735.017,2011.41705222126,829312432.582254,11.1480629920271,44912.9866634021,16.2666889401153 +"S1NoCD",74388425,138942645766.805,1867.79926805554,829048976.694961,11.144865302565,NA,0 +"S2NoCD",44157029,102687192587.025,2325.50049023961,481821542.857639,10.9115480314049,NA,0 +"S3NoCD",34491937,87288548274.2129,2530.69429745894,346433081.148818,10.0438859420629,NA,0 diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation3yrs.md index 6d1cbeb..7b2baee 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: No Smoking Cessation ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD | 37204854 | 626018225 | 71202557 | 190989723 | 13185986 | 13393668 | 0.017 | 0.135 | 0.151 | 0.080 | 15418908 | 2881539 | 4847882 | 418531.0 | 0.217 | 0.040 | 0.068 | 0.006 | 527413624 | 28872284 | 30752411 | 6896116 | 1196927 | 79594247521 | 2139.351 | 466658875 | 12.543 | 625008.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37191950 | 625889056 | 71140468 | 124648922 | 13317440 | 16364556 | 0.021 | 0.135 | 0.151 | 0.080 | 15424253 | 2881148 | 4845493 | 417620.0 | 0.217 | 0.040 | 0.068 | 0.006 | 527349723 | 28843031 | 30716736 | 6901546 | 1197088 | 79628195883 | 2141.006 | 466565294 | 12.545 | 625098.6 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37198402 | 625953640 | 71171513 | 157819322 | 13251713 | 14879112 | 0.019 | 0.135 | 0.151 | 0.080 | 15421580 | 2881344 | 4846688 | 418075.5 | 0.217 | 0.040 | 0.068 | 0.006 | 527381674 | 28857658 | 30734574 | 6898831 | 1197008 | 79611221702 | 2140.179 | 466612084 | 12.544 | 625053.6 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37192142 | 625969287 | 71224394 | 186049005 | 33074933 | 13391900 | 0.026 | 0.158 | 0.309 | 0.094 | 14927938 | 2802971 | 4729427 | 409469.0 | 0.210 | 0.039 | 0.066 | 0.006 | 527343988 | 28826967 | 30773139 | 6928614 | 1207834 | 90029166181 | 2420.650 | 467067252 | 12.558 | 625490.6 | 281.299 | 0.015 | 18424.96 | 482.065 | -| S1b | 37187925 | 625865189 | 71225582 | 188347039 | 23789318 | 13384883 | 0.022 | 0.148 | 0.240 | 0.087 | 15135261 | 2838459 | 4782768 | 413956.0 | 0.212 | 0.040 | 0.067 | 0.006 | 527244837 | 28851409 | 30762414 | 6920861 | 1204334 | 87358830750 | 2349.118 | 466782406 | 12.552 | 625250.3 | 209.767 | 0.009 | 23225.59 | 241.819 | -| S1c | 37195823 | 625981366 | 71238478 | 189184178 | 20552964 | 13386224 | 0.020 | 0.144 | 0.214 | 0.085 | 15223475 | 2857925 | 4803132 | 415166.0 | 0.214 | 0.040 | 0.067 | 0.006 | 527342147 | 28839813 | 30776139 | 6931391 | 1205136 | 88369606438 | 2375.794 | 466792527 | 12.550 | 625104.0 | 236.443 | 0.007 | 35616.38 | 95.487 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD | 74397625 | 1251888615 | 142400097 | 381936924 | 26358454 | 26783324 | 0.017 | 0.135 | 0.151 | 0.080 | 30847754 | 5758388 | 9691126 | 836590 | 0.217 | 0.040 | 0.068 | 0.006 | 1054688429 | 57727616 | 61505481 | 13799186 | 2398591 | 159124648209 | 2138.840 | 933200651 | 12.543 | 625032.2 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74394066 | 1251871999 | 142377758 | 249324170 | 26617487 | 32718146 | 0.021 | 0.135 | 0.151 | 0.080 | 30874590 | 5768744 | 9690479 | 835272 | 0.217 | 0.041 | 0.068 | 0.006 | 1054693564 | 57729618 | 61465178 | 13817742 | 2397911 | 159276748461 | 2140.987 | 933192471 | 12.544 | 625054.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74395846 | 1251880307 | 142388928 | 315630547 | 26487970 | 29750735 | 0.019 | 0.135 | 0.151 | 0.080 | 30861172 | 5763566 | 9690802 | 835931 | 0.217 | 0.040 | 0.068 | 0.006 | 1054690996 | 57728617 | 61485330 | 13808464 | 2398251 | 159200698335 | 2139.914 | 933196561 | 12.544 | 625043.3 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74394771 | 1252091491 | 142557438 | 372128624 | 66213412 | 26771781 | 0.026 | 0.159 | 0.310 | 0.094 | 29914376 | 5620783 | 9479364 | 819537 | 0.210 | 0.039 | 0.066 | 0.006 | 1054733720 | 57720098 | 61584515 | 13858892 | 2416178 | 180319782953 | 2423.823 | 934242431 | 12.558 | 625471.4 | 284.983 | 0.014 | 19674.89 | 439.247 | +| S1b | 74384118 | 1251703447 | 142505867 | 376679454 | 47607164 | 26787921 | 0.022 | 0.148 | 0.240 | 0.088 | 30296542 | 5680532 | 9581587 | 826935 | 0.213 | 0.040 | 0.067 | 0.006 | 1054408482 | 57730018 | 61529087 | 13855676 | 2416625 | 174899343545 | 2351.300 | 933542720 | 12.550 | 625163.5 | 212.459 | 0.007 | 30896.97 | 131.360 | +| S1c | 74390209 | 1251828104 | 142354152 | 378340031 | 41045426 | 26779722 | 0.020 | 0.144 | 0.214 | 0.085 | 30433623 | 5703967 | 9612703 | 829564 | 0.214 | 0.040 | 0.068 | 0.006 | 1054672194 | 57623840 | 61512975 | 13840093 | 2409156 | 176728465906 | 2375.695 | 933496178 | 12.549 | 625056.5 | 236.855 | 0.005 | 45347.36 | 24.301 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ------: | -------------: | -| S2NoCD | 22078475 | 364456518 | 50216445 | 110945016 | 9669472 | 7747302 | 0.017 | 0.141 | 0.159 | 0.087 | 11485953 | 2127051 | 3548098 | 303898 | 0.229 | 0.042 | 0.071 | 0.006 | 298681487 | 18624314 | 22530486 | 5565392 | 1033338 | 58623262798 | 2655.222 | 270860549 | 12.268 | 610748.9 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22076350 | 364496013 | 50208573 | 108779574 | 18474524 | 7734901 | 0.023 | 0.157 | 0.268 | 0.097 | 11218640 | 2089613 | 3490800 | 299139 | 0.223 | 0.042 | 0.070 | 0.006 | 298727047 | 18618226 | 22519514 | 5573954 | 1032785 | 63456641765 | 2874.417 | 271102266 | 12.280 | 611136.2 | 219.195 | 0.012 | 18070.4 | 387.308 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44166055 | 729117912 | 100405688 | 221954036 | 19343537 | 15478949 | 0.017 | 0.141 | 0.159 | 0.087 | 22957271 | 4249333 | 7089574 | 607905 | 0.229 | 0.042 | 0.071 | 0.006 | 597585749 | 37297625 | 44999354 | 11122450 | 2059355 | 117144112006 | 2652.356 | 541887056 | 12.269 | 610813.2 | 0.000 | 0.00 | NaN | 0.000 | +| S2a | 44161595 | 729112649 | 100432995 | 217571137 | 37001975 | 15492083 | 0.023 | 0.157 | 0.269 | 0.097 | 22424977 | 4176799 | 6987343 | 599803 | 0.223 | 0.042 | 0.070 | 0.006 | 597552506 | 37218775 | 45066339 | 11152095 | 2067861 | 127021423440 | 2876.287 | 542294220 | 12.280 | 611112.2 | 223.931 | 0.01 | 21410.38 | 299.018 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | -| S3NoCD | 17251004 | 260100353 | 41760352 | 80093301 | 7808220 | 5817970 | 0.018 | 0.137 | 0.154 | 0.086 | 9778778 | 1815130 | 3033059 | 260471 | 0.234 | 0.043 | 0.073 | 0.006 | 207449252 | 15297713 | 18728772 | 4824301 | 894240 | 49706422473 | 2881.364 | 193732612 | 11.230 | 558629.8 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17249134 | 260008283 | 41776161 | 79278529 | 11011389 | 5822190 | 0.021 | 0.143 | 0.204 | 0.090 | 9676022 | 1805447 | 3016891 | 260109 | 0.232 | 0.043 | 0.072 | 0.006 | 207345092 | 15302232 | 18726703 | 4829095 | 900681 | 52783263535 | 3060.053 | 193741259 | 11.232 | 558537.0 | 178.689 | 0.002 | 103962.75 | \-92.750 | -| S3b | 17250219 | 260104940 | 41785281 | 77779970 | 17177315 | 5822903 | 0.027 | 0.155 | 0.293 | 0.099 | 9510791 | 1780204 | 2977917 | 255631 | 0.228 | 0.043 | 0.071 | 0.006 | 207430795 | 15293333 | 18729492 | 4839340 | 904959 | 54744732216 | 3173.567 | 193956703 | 11.244 | 559012.6 | 292.203 | 0.014 | 21642.00 | 382.881 | -| S3c | 17252836 | 260148464 | 41767142 | 78572238 | 14061462 | 5825793 | 0.024 | 0.149 | 0.249 | 0.095 | 9589326 | 1791300 | 2996772 | 256745 | 0.230 | 0.043 | 0.072 | 0.006 | 207489733 | 15294751 | 18722619 | 4831059 | 901887 | 53445425796 | 3097.776 | 193919005 | 11.240 | 558893.9 | 216.412 | 0.010 | 22516.88 | 264.143 | -| S3d | 17252575 | 260145756 | 41795158 | 78912696 | 12676670 | 5832474 | 0.023 | 0.146 | 0.229 | 0.093 | 9621629 | 1796623 | 3007738 | 257735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459074 | 15309738 | 18741138 | 4826857 | 900538 | 53805052918 | 3118.668 | 193882222 | 11.238 | 558774.9 | 237.304 | 0.008 | 31023.66 | 145.152 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34500349 | 520094995 | 83461691 | 160143901 | 15618828 | 11654651 | 0.018 | 0.137 | 0.154 | 0.086 | 19547537 | 3636418 | 6069919 | 520617 | 0.234 | 0.044 | 0.073 | 0.006 | 414853261 | 30586952 | 37418093 | 9635730 | 1793033 | 99418734054 | 2881.673 | 387394495 | 11.229 | 558553.9 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34498365 | 520044251 | 83543965 | 158570002 | 22025358 | 11641972 | 0.021 | 0.143 | 0.204 | 0.090 | 19349214 | 3610114 | 6036237 | 518479 | 0.232 | 0.043 | 0.072 | 0.006 | 414726752 | 30585780 | 37465015 | 9656171 | 1804975 | 105579216551 | 3060.412 | 387503366 | 11.233 | 558565.3 | 178.739 | 0.004 | 47016.76 | 11.341 | +| S3b | 34505121 | 520325831 | 83596107 | 155591308 | 34370572 | 11646287 | 0.027 | 0.155 | 0.292 | 0.099 | 19045362 | 3554737 | 5952719 | 512271 | 0.228 | 0.043 | 0.071 | 0.006 | 414946581 | 30589147 | 37475808 | 9683238 | 1812590 | 109490006079 | 3173.152 | 387996999 | 11.245 | 559057.9 | 291.479 | 0.016 | 18322.35 | 503.940 | +| S3c | 34505668 | 520264309 | 83596889 | 157131912 | 28149353 | 11644831 | 0.024 | 0.149 | 0.249 | 0.095 | 19179049 | 3582497 | 6000047 | 515697 | 0.229 | 0.043 | 0.072 | 0.006 | 414890025 | 30618993 | 37472630 | 9661994 | 1807193 | 107022937523 | 3101.605 | 387810723 | 11.239 | 558850.6 | 219.931 | 0.010 | 21287.01 | 296.654 | +| S3d | 34507875 | 520253275 | 83509443 | 157815894 | 25352833 | 11646210 | 0.023 | 0.146 | 0.229 | 0.093 | 19265713 | 3593496 | 6016041 | 515763 | 0.231 | 0.043 | 0.072 | 0.006 | 414960418 | 30586470 | 37432733 | 9658194 | 1800918 | 107608997577 | 3118.390 | 387745308 | 11.236 | 558703.1 | 236.716 | 0.008 | 30673.67 | 149.146 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | --------: | -------------: | -| S1a | 37192142 | 90029166181 | 2420.650 | 467067252 | 12.558 | 18424.96 | 482.065 | -| S2a | 22076350 | 63456641765 | 2874.417 | 271102266 | 12.280 | 18070.40 | 387.308 | -| S3b | 17250219 | 54744732216 | 3173.567 | 193956703 | 11.244 | 21642.00 | 382.881 | -| S3c | 17252836 | 53445425796 | 3097.776 | 193919005 | 11.240 | 22516.88 | 264.143 | -| S1b | 37187925 | 87358830750 | 2349.118 | 466782406 | 12.552 | 23225.59 | 241.819 | -| S3d | 17252575 | 53805052918 | 3118.668 | 193882222 | 11.238 | 31023.66 | 145.152 | -| S1c | 37195823 | 88369606438 | 2375.794 | 466792527 | 12.550 | 35616.38 | 95.487 | -| S1NoCD | 37204854 | 79594247521 | 2139.351 | 466658875 | 12.543 | NaN | 0.000 | -| S2NoCD | 22078475 | 58623262798 | 2655.222 | 270860549 | 12.268 | NaN | 0.000 | -| S3NoCD | 17251004 | 49706422473 | 2881.364 | 193732612 | 11.230 | NaN | 0.000 | -| S3a | 17249134 | 52783263535 | 3060.053 | 193741259 | 11.232 | 103962.75 | \-92.750 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S3b | 34505121 | 109490006079 | 3173.152 | 387996999 | 11.245 | 18322.35 | 503.940 | +| S1a | 74394771 | 180319782953 | 2423.823 | 934242431 | 12.558 | 19674.89 | 439.247 | +| S2a | 44161595 | 127021423440 | 2876.287 | 542294220 | 12.280 | 21410.38 | 299.018 | +| S3c | 34505668 | 107022937523 | 3101.605 | 387810723 | 11.239 | 21287.01 | 296.654 | +| S3d | 34507875 | 107608997577 | 3118.390 | 387745308 | 11.236 | 30673.67 | 149.146 | +| S1b | 74384118 | 174899343545 | 2351.300 | 933542720 | 12.550 | 30896.97 | 131.360 | +| S1c | 74390209 | 176728465906 | 2375.695 | 933496178 | 12.549 | 45347.36 | 24.301 | +| S3a | 34498365 | 105579216551 | 3060.412 | 387503366 | 11.233 | 47016.76 | 11.341 | +| S1NoCD | 74397625 | 159124648209 | 2138.840 | 933200651 | 12.543 | NaN | 0.000 | +| S2NoCD | 44166055 | 117144112006 | 2652.356 | 541887056 | 12.269 | NaN | 0.000 | +| S3NoCD | 34500349 | 99418734054 | 2881.673 | 387394495 | 11.229 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | --------: | ---------: | -| S1NoCDAvg | 37198402 | 1.0000000 | 79611221702 | 2140.179 | 0.000 | 2140.179 | 466612084 | 12.54387 | 0.00000 | 12.54387 | 0.0000 | 0.0000000 | NaN | NaN | 0.00000 | -| S1a | 37192142 | 1.0000000 | 90029166181 | 2420.650 | 0.000 | 2420.650 | 467067252 | 12.55822 | 0.00000 | 12.55822 | 280.4717 | 0.0143496 | 19545.61 | 18424.96 | 437.00810 | -| S1b | 37187925 | 1.0000000 | 87358830750 | 2349.118 | 0.000 | 2349.118 | 466782406 | 12.55199 | 0.00000 | 12.55199 | 208.9396 | 0.0081140 | 25750.41 | 23225.59 | 196.76202 | -| S1c | 37195823 | 1.0000000 | 88369606438 | 2375.794 | 0.000 | 2375.794 | 466792527 | 12.54960 | 0.00000 | 12.54960 | 235.6153 | 0.0057209 | 41184.96 | 35616.38 | 50.43005 | -| S2NoCD | 22078475 | 0.5935329 | 58623262798 | 2655.222 | 1388.099 | 2140.179 | 270860549 | 12.26808 | 12.94659 | 12.54387 | 0.0000 | 0.0000000 | NaN | NaN | 0.00000 | -| S2a | 22076350 | 0.5934758 | 63456641765 | 2874.417 | 1388.099 | 2270.193 | 271102266 | 12.28021 | 12.94659 | 12.55111 | 130.0144 | 0.0072377 | 17963.62 | 18070.40 | 231.86809 | -| S3NoCD | 17251004 | 0.4637566 | 49706422473 | 2881.364 | 1499.183 | 2140.179 | 193732612 | 11.23022 | 13.67995 | 12.54387 | 0.0000 | 0.0000000 | NaN | NaN | 0.00000 | -| S3a | 17249134 | 0.4637063 | 52783263535 | 3060.053 | 1499.183 | 2222.968 | 193741259 | 11.23194 | 13.67995 | 12.54479 | 82.7897 | 0.0009202 | 89973.28 | 103962.75 | \-36.78176 | -| S3b | 17250219 | 0.4637355 | 54744732216 | 3173.567 | 1499.183 | 2275.654 | 193956703 | 11.24372 | 13.67995 | 12.55019 | 135.4759 | 0.0063129 | 21460.15 | 21642.00 | 180.16932 | -| S3c | 17252836 | 0.4638058 | 53445425796 | 3097.776 | 1499.183 | 2240.620 | 193919005 | 11.23983 | 13.67995 | 12.54821 | 100.4413 | 0.0043370 | 23158.95 | 22516.88 | 116.41073 | -| S3d | 17252575 | 0.4637988 | 53805052918 | 3118.668 | 1499.183 | 2250.298 | 193882222 | 11.23787 | 13.67995 | 12.54732 | 110.1197 | 0.0034442 | 31972.52 | 31023.66 | 62.09018 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | +| S1NoCDAvg | 74395846 | 1.0000000 | 159200698335 | 2139.914 | 0.000 | 2139.914 | 933196561 | 12.54367 | 0.00000 | 12.54367 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | +| S1a | 74394771 | 1.0000000 | 180319782953 | 2423.823 | 0.000 | 2423.823 | 934242431 | 12.55790 | 0.00000 | 12.55790 | 283.90952 | 0.0142395 | 19938.10 | 19674.89 | 428.0679251 | +| S1b | 74384118 | 1.0000000 | 174899343545 | 2351.300 | 0.000 | 2351.300 | 933542720 | 12.55030 | 0.00000 | 12.55030 | 211.38573 | 0.0066313 | 31876.86 | 30896.97 | 120.1803646 | +| S1c | 74390209 | 1.0000000 | 176728465906 | 2375.695 | 0.000 | 2375.695 | 933496178 | 12.54864 | 0.00000 | 12.54864 | 235.78142 | 0.0049781 | 47364.02 | 45347.36 | 13.1220799 | +| S2NoCD | 44166055 | 0.5936629 | 117144112006 | 2652.356 | 1391.230 | 2139.914 | 541887056 | 12.26931 | 12.94450 | 12.54366 | 0.00000 | 0.0000000 | NaN | NaN | \-0.0042008 | +| S2a | 44161595 | 0.5936030 | 127021423440 | 2876.287 | 1391.230 | 2272.764 | 542294220 | 12.27977 | 12.94450 | 12.54991 | 132.85038 | 0.0062490 | 21259.60 | 21410.38 | 179.5934649 | +| S3NoCD | 34500349 | 0.4637403 | 99418734054 | 2881.673 | 1498.464 | 2139.914 | 387394495 | 11.22871 | 13.68079 | 12.54366 | 0.00000 | 0.0000000 | NaN | NaN | \-0.0042008 | +| S3a | 34498365 | 0.4637136 | 105579216551 | 3060.412 | 1498.464 | 2222.761 | 387503366 | 11.23251 | 13.68079 | 12.54549 | 82.84677 | 0.0018282 | 45314.89 | 47016.76 | 8.5613330 | +| S3b | 34505121 | 0.4638044 | 109490006079 | 3173.152 | 1498.464 | 2275.192 | 387996999 | 11.24462 | 13.68079 | 12.55089 | 135.27800 | 0.0072211 | 18733.72 | 18322.35 | 225.7726271 | +| S3c | 34505668 | 0.4638118 | 107022937523 | 3101.605 | 1498.464 | 2242.019 | 387810723 | 11.23904 | 13.68079 | 12.54828 | 102.10561 | 0.0046167 | 22116.79 | 21287.02 | 128.7229448 | +| S3d | 34507875 | 0.4638414 | 107608997577 | 3118.390 | 1498.464 | 2249.853 | 387745308 | 11.23643 | 13.68079 | 12.54700 | 109.93875 | 0.0033315 | 32999.56 | 30673.67 | 56.6331517 | ![](../../outputs/Sen1_No_Smoking_Cessation_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190548 | 0.1354468 | 0.1513316 | 0.0796706 | 0.4145764 | 0.0774588 | 0.1302929 | 0.0112391 | 0.8425251 | 0.0461019 | 0.0491004 | 0.0110213 | 0.0019123 | 0.1861941 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264454 | 0.1583594 | 0.3090867 | 0.0938685 | 0.4013734 | 0.0753646 | 0.1271620 | 0.0110096 | 0.8424439 | 0.0460517 | 0.0491608 | 0.0110686 | 0.0019295 | 0.4643765 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216384 | 0.1475344 | 0.2402284 | 0.0873071 | 0.4069940 | 0.0763274 | 0.1286108 | 0.0111315 | 0.8424256 | 0.0460984 | 0.0491518 | 0.0110581 | 0.0019243 | 0.3339996 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201783 | 0.1438319 | 0.2141226 | 0.0849923 | 0.4092792 | 0.0768346 | 0.1291310 | 0.0111616 | 0.8424247 | 0.0460714 | 0.0491646 | 0.0110728 | 0.0019252 | 0.2885093 | -| S2NoCD | 0.5935329 | 0.5822420 | 0.7055694 | 0.0190548 | 0.1354468 | 0.1513316 | 0.0796706 | 0.4145764 | 0.0774588 | 0.1302929 | 0.0112391 | 0.8425251 | 0.0461019 | 0.0491004 | 0.0110213 | 0.0019123 | 0.1861941 | -| S2a | 0.5934758 | 0.5823051 | 0.7054588 | 0.0224000 | 0.1461087 | 0.2284248 | 0.0865713 | 0.4074052 | 0.0764552 | 0.1287575 | 0.0111116 | 0.8425427 | 0.0460897 | 0.0490809 | 0.0110347 | 0.0019114 | 0.3099289 | -| S3NoCD | 0.4637566 | 0.4155265 | 0.5867566 | 0.0190548 | 0.1354468 | 0.1513316 | 0.0796706 | 0.4145764 | 0.0774588 | 0.1302929 | 0.0112391 | 0.8425251 | 0.0461019 | 0.0491004 | 0.0110213 | 0.0019123 | 0.1861941 | -| S3a | 0.4637063 | 0.4153795 | 0.5869787 | 0.0201725 | 0.1391827 | 0.1806146 | 0.0822113 | 0.4118283 | 0.0772012 | 0.1298628 | 0.0112297 | 0.8424874 | 0.0461146 | 0.0491019 | 0.0110298 | 0.0019227 | 0.2311593 | -| S3b | 0.4637355 | 0.4155339 | 0.5871068 | 0.0227387 | 0.1465216 | 0.2329580 | 0.0870327 | 0.4073781 | 0.0765210 | 0.1288124 | 0.0111091 | 0.8424892 | 0.0460946 | 0.0491013 | 0.0110453 | 0.0019294 | 0.3177703 | -| S3c | 0.4638058 | 0.4156034 | 0.5868520 | 0.0213773 | 0.1429184 | 0.2072041 | 0.0846795 | 0.4094695 | 0.0768155 | 0.1293129 | 0.0111385 | 0.8425226 | 0.0460943 | 0.0490880 | 0.0110317 | 0.0019244 | 0.2740380 | -| S3d | 0.4637988 | 0.4155991 | 0.5872456 | 0.0208136 | 0.1411855 | 0.1953009 | 0.0836058 | 0.4103399 | 0.0769590 | 0.1296084 | 0.0111652 | 0.8424774 | 0.0461184 | 0.0491178 | 0.0110250 | 0.0019223 | 0.2545080 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190473 | 0.1352836 | 0.1511410 | 0.0795532 | 0.4148239 | 0.0774716 | 0.1302600 | 0.0112363 | 0.8424855 | 0.0461135 | 0.0491144 | 0.0110302 | 0.0019157 | 0.1860255 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264236 | 0.1585082 | 0.3095994 | 0.0937869 | 0.4021032 | 0.0755535 | 0.1274198 | 0.0110161 | 0.8423775 | 0.0460989 | 0.0491853 | 0.0110686 | 0.0019297 | 0.4644683 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216557 | 0.1477093 | 0.2403393 | 0.0875356 | 0.4072985 | 0.0763675 | 0.1288123 | 0.0111171 | 0.8423788 | 0.0461212 | 0.0491563 | 0.0110695 | 0.0019307 | 0.3340716 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201669 | 0.1439219 | 0.2141501 | 0.0851948 | 0.4091079 | 0.0766763 | 0.1292200 | 0.0111515 | 0.8425056 | 0.0460318 | 0.0491385 | 0.0110559 | 0.0019245 | 0.2883332 | +| S2NoCD | 0.5936629 | 0.5824182 | 0.7051510 | 0.0190473 | 0.1352836 | 0.1511410 | 0.0795532 | 0.4148239 | 0.0774716 | 0.1302600 | 0.0112363 | 0.8424855 | 0.0461135 | 0.0491144 | 0.0110302 | 0.0019157 | 0.1860255 | +| S2a | 0.5936030 | 0.5824140 | 0.7053427 | 0.0224080 | 0.1461094 | 0.2285254 | 0.0866425 | 0.4076846 | 0.0764996 | 0.1288910 | 0.0111278 | 0.8424626 | 0.0460507 | 0.0491680 | 0.0110539 | 0.0019225 | 0.3100084 | +| S3NoCD | 0.4637403 | 0.4154511 | 0.5861530 | 0.0190473 | 0.1352836 | 0.1511410 | 0.0795532 | 0.4148239 | 0.0774716 | 0.1302600 | 0.0112363 | 0.8424855 | 0.0461135 | 0.0491144 | 0.0110302 | 0.0019157 | 0.1860255 | +| S3a | 0.4637136 | 0.4154105 | 0.5867308 | 0.0201580 | 0.1390265 | 0.1803887 | 0.0821315 | 0.4121656 | 0.0771195 | 0.1298097 | 0.0112077 | 0.8424199 | 0.0461141 | 0.0491532 | 0.0110467 | 0.0019253 | 0.2309121 | +| S3b | 0.4638044 | 0.4156354 | 0.5870970 | 0.0227316 | 0.1462341 | 0.2324623 | 0.0869039 | 0.4080556 | 0.0763703 | 0.1286788 | 0.0111236 | 0.8423988 | 0.0461084 | 0.0491544 | 0.0110671 | 0.0019312 | 0.3175452 | +| S3c | 0.4638118 | 0.4155863 | 0.5871025 | 0.0213685 | 0.1426453 | 0.2068680 | 0.0845367 | 0.4098505 | 0.0767430 | 0.1293143 | 0.0111696 | 0.8423966 | 0.0461341 | 0.0491535 | 0.0110504 | 0.0019269 | 0.2738525 | +| S3d | 0.4638414 | 0.4155775 | 0.5864883 | 0.0207967 | 0.1410580 | 0.1950703 | 0.0834919 | 0.4110070 | 0.0768893 | 0.1295266 | 0.0111702 | 0.8424605 | 0.0461085 | 0.0491219 | 0.0110474 | 0.0019219 | 0.2543257 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 15.45267 hours + ## Time difference of 1.275262 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation5yrs.md index a208e25..1b4a692 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen1_No_Smoking_Cessation5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: No Smoking Cessation ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD2 | 37204854 | 626018225 | 71202557 | 190989723 | 13185986 | 13393668 | 0.017 | 0.135 | 0.151 | 0.080 | 15418908 | 2881539 | 4847882 | 418531.0 | 0.217 | 0.04 | 0.068 | 0.006 | 527413624 | 28872284 | 30752411 | 6896116 | 1196927 | 79594247521 | 2139.351 | 466658875 | 12.543 | 625008.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37191950 | 625889056 | 71140468 | 124648922 | 13317440 | 16364556 | 0.021 | 0.135 | 0.151 | 0.080 | 15424253 | 2881148 | 4845493 | 417620.0 | 0.217 | 0.04 | 0.068 | 0.006 | 527349723 | 28843031 | 30716736 | 6901546 | 1197088 | 79628195883 | 2141.006 | 466565294 | 12.545 | 625098.6 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37198402 | 625953640 | 71171513 | 157819322 | 13251713 | 14879112 | 0.019 | 0.135 | 0.151 | 0.080 | 15421580 | 2881344 | 4846688 | 418075.5 | 0.217 | 0.04 | 0.068 | 0.006 | 527381674 | 28857658 | 30734574 | 6898831 | 1197008 | 79611221702 | 2140.179 | 466612084 | 12.544 | 625053.6 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195208 | 625981312 | 71272710 | 122751743 | 28526479 | 16361764 | 0.028 | 0.153 | 0.273 | 0.091 | 15061201 | 2823590 | 4759004 | 410782.0 | 0.211 | 0.04 | 0.067 | 0.006 | 527310202 | 28846066 | 30794056 | 6933389 | 1210614 | 87015658430 | 2339.432 | 466968792 | 12.555 | 625387.7 | 198.426 | 0.010 | 20352.83 | 289.039 | -| S1b | 37197852 | 625993620 | 71228378 | 123724740 | 20971968 | 16356344 | 0.024 | 0.145 | 0.216 | 0.086 | 15200763 | 2850096 | 4806431 | 415178.0 | 0.213 | 0.04 | 0.067 | 0.006 | 527361769 | 28875770 | 30751567 | 6911893 | 1202019 | 85019682451 | 2285.607 | 466815725 | 12.550 | 625191.1 | 144.601 | 0.005 | 30493.80 | 92.498 | -| S1c | 37186225 | 625816475 | 71183274 | 123996885 | 18524349 | 16346258 | 0.023 | 0.142 | 0.196 | 0.084 | 15269130 | 2861634 | 4811385 | 414801.0 | 0.215 | 0.04 | 0.068 | 0.006 | 527237782 | 28835965 | 30741638 | 6918866 | 1201850 | 85476215421 | 2298.599 | 466624752 | 12.548 | 625117.5 | 157.593 | 0.004 | 44640.36 | 18.921 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD2 | 74397625 | 1251888615 | 142400097 | 381936924 | 26358454 | 26783324 | 0.017 | 0.135 | 0.151 | 0.080 | 30847754 | 5758388 | 9691126 | 836590 | 0.217 | 0.040 | 0.068 | 0.006 | 1054688429 | 57727616 | 61505481 | 13799186 | 2398591 | 159124648209 | 2138.840 | 933200651 | 12.543 | 625032.2 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74394066 | 1251871999 | 142377758 | 249324170 | 26617487 | 32718146 | 0.021 | 0.135 | 0.151 | 0.080 | 30874590 | 5768744 | 9690479 | 835272 | 0.217 | 0.041 | 0.068 | 0.006 | 1054693564 | 57729618 | 61465178 | 13817742 | 2397911 | 159276748461 | 2140.987 | 933192471 | 12.544 | 625054.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74395846 | 1251880307 | 142388928 | 315630547 | 26487970 | 29750735 | 0.019 | 0.135 | 0.151 | 0.080 | 30861172 | 5763566 | 9690802 | 835931 | 0.217 | 0.040 | 0.068 | 0.006 | 1054690996 | 57728617 | 61485330 | 13808464 | 2398251 | 159200698335 | 2139.914 | 933196561 | 12.544 | 625043.3 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386358 | 1251896635 | 142473656 | 245503789 | 56984175 | 32705395 | 0.028 | 0.153 | 0.273 | 0.091 | 30081756 | 5637945 | 9520747 | 824685 | 0.211 | 0.040 | 0.067 | 0.006 | 1054623394 | 57686664 | 61571086 | 13837097 | 2404913 | 174028848972 | 2339.526 | 933898758 | 12.555 | 625395.7 | 198.539 | 0.011 | 18392.33 | 341.194 | +| S1b | 74391545 | 1251861823 | 142462209 | 247434066 | 41931074 | 32705922 | 0.024 | 0.144 | 0.216 | 0.085 | 30421419 | 5696210 | 9605672 | 831014 | 0.214 | 0.040 | 0.067 | 0.006 | 1054598750 | 57721840 | 61546620 | 13822533 | 2398634 | 169947664017 | 2284.502 | 933536456 | 12.549 | 625163.5 | 143.515 | 0.005 | 28424.02 | 108.939 | +| S1c | 74393824 | 1251906428 | 142431705 | 248055301 | 37051931 | 32690365 | 0.023 | 0.142 | 0.196 | 0.084 | 30561505 | 5718432 | 9635256 | 832645 | 0.215 | 0.040 | 0.068 | 0.006 | 1054677312 | 57725840 | 61509508 | 13822224 | 2401731 | 171127045501 | 2300.286 | 933458732 | 12.548 | 625076.2 | 159.298 | 0.004 | 44006.44 | 21.696 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22087417 | 364646034 | 50186627 | 72526119 | 9746775 | 9462789 | 0.021 | 0.142 | 0.159 | 0.087 | 11464621 | 2124260 | 3543653 | 304619 | 0.228 | 0.042 | 0.071 | 0.006 | 298890008 | 18629794 | 22515326 | 5556637 | 1022110 | 58618311506 | 2653.923 | 271012140 | 12.270 | 610845.0 | 0.000 | 0.000 | NaN | 0.00 | -| S2a | 22083208 | 364595007 | 50239139 | 71692048 | 16275036 | 9453921 | 0.025 | 0.153 | 0.241 | 0.095 | 11292655 | 2099389 | 3509042 | 300286 | 0.225 | 0.042 | 0.070 | 0.006 | 298790965 | 18626223 | 22537013 | 5579347 | 1031500 | 62093405681 | 2811.793 | 271120515 | 12.277 | 611049.5 | 157.869 | 0.007 | 21786.54 | 204.44 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44157584 | 728952311 | 100323388 | 144982166 | 19523088 | 18911929 | 0.021 | 0.142 | 0.160 | 0.087 | 22913196 | 4246236 | 7091076 | 607396 | 0.228 | 0.042 | 0.071 | 0.006 | 597502927 | 37198908 | 45025648 | 11128697 | 2049374 | 117261957083 | 2655.534 | 541767607 | 12.269 | 610792.4 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44167644 | 729258231 | 100451469 | 143393557 | 32589486 | 18909118 | 0.025 | 0.153 | 0.241 | 0.095 | 22572868 | 4195555 | 7015184 | 599814 | 0.225 | 0.042 | 0.070 | 0.006 | 597673662 | 37222091 | 45078868 | 11153960 | 2067390 | 124138133751 | 2810.613 | 542293812 | 12.278 | 611093.3 | 155.079 | 0.009 | 17005.48 | 300.888 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17252656 | 260094783 | 41770599 | 52444190 | 7909135 | 7072687 | 0.022 | 0.137 | 0.154 | 0.086 | 9782958 | 1820515 | 3040238 | 260475 | 0.234 | 0.044 | 0.073 | 0.006 | 207435240 | 15306525 | 18721148 | 4829059 | 898040 | 49824346254 | 2887.923 | 193730581 | 11.229 | 558563.5 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17243481 | 259912088 | 41699334 | 52142253 | 10110197 | 7079583 | 0.024 | 0.141 | 0.189 | 0.089 | 9688105 | 1805528 | 3020469 | 258826 | 0.232 | 0.043 | 0.072 | 0.006 | 207327257 | 15287458 | 18694698 | 4811886 | 892931 | 51742662653 | 3000.709 | 193656912 | 11.231 | 558535.9 | 112.785 | 0.002 | 66246.23 | \-27.660 | -| S3b | 17247748 | 260025001 | 41817481 | 51563538 | 14906855 | 7078800 | 0.029 | 0.151 | 0.258 | 0.096 | 9577831 | 1791238 | 2994241 | 257043 | 0.229 | 0.043 | 0.072 | 0.006 | 207321180 | 15322740 | 18744664 | 4830073 | 901996 | 53304765553 | 3090.535 | 193842443 | 11.239 | 558845.0 | 202.612 | 0.010 | 20929.02 | 281.433 | -| S3c | 17255289 | 260150051 | 41793716 | 51902628 | 12418598 | 7087241 | 0.026 | 0.146 | 0.222 | 0.092 | 9642590 | 1800040 | 3010319 | 258524 | 0.231 | 0.043 | 0.072 | 0.006 | 207466781 | 15314112 | 18733822 | 4827468 | 899118 | 52372898312 | 3035.179 | 193880135 | 11.236 | 558764.0 | 147.256 | 0.007 | 21176.66 | 200.429 | -| S3d | 17249786 | 260094642 | 41791504 | 52022800 | 11361111 | 7083958 | 0.025 | 0.144 | 0.207 | 0.091 | 9669545 | 1804309 | 3019811 | 259616 | 0.231 | 0.043 | 0.072 | 0.006 | 207414812 | 15305575 | 18740388 | 4830487 | 898472 | 52605759305 | 3049.647 | 193811771 | 11.236 | 558730.6 | 161.724 | 0.007 | 24596.88 | 167.025 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34503305 | 520131900 | 83566026 | 104876864 | 15818113 | 14153690 | 0.022 | 0.137 | 0.154 | 0.086 | 19571024 | 3639873 | 6075336 | 520651 | 0.234 | 0.044 | 0.073 | 0.006 | 414791492 | 30617496 | 37480217 | 9639095 | 1796669 | 99600427724 | 2886.692 | 387416791 | 11.228 | 558533.1 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34502959 | 520214215 | 83507663 | 104354722 | 20256743 | 14160507 | 0.024 | 0.141 | 0.189 | 0.089 | 19411438 | 3617031 | 6045913 | 519219 | 0.232 | 0.043 | 0.072 | 0.006 | 414923874 | 30575250 | 37437201 | 9663951 | 1800433 | 103657451678 | 3004.306 | 387588700 | 11.233 | 558670.3 | 117.614 | 0.005 | 23083.96 | 137.138 | +| S3b | 34499019 | 520184485 | 83582574 | 103156699 | 29799478 | 14153270 | 0.029 | 0.151 | 0.258 | 0.096 | 19153466 | 3575091 | 5985288 | 514510 | 0.229 | 0.043 | 0.072 | 0.006 | 414823125 | 30587889 | 37477414 | 9673157 | 1810964 | 106572608911 | 3089.149 | 387784278 | 11.240 | 558933.0 | 202.457 | 0.012 | 16805.46 | 399.897 | +| S3c | 34498158 | 520070825 | 83518338 | 103759249 | 24845682 | 14164602 | 0.026 | 0.146 | 0.223 | 0.093 | 19273175 | 3595164 | 6016844 | 516053 | 0.231 | 0.043 | 0.072 | 0.006 | 414775743 | 30587857 | 37449770 | 9650222 | 1799422 | 104673766491 | 3034.184 | 387592275 | 11.235 | 558723.7 | 147.492 | 0.007 | 21811.80 | 190.609 | +| S3d | 34499680 | 520130180 | 83530301 | 104037313 | 22709145 | 14168991 | 0.025 | 0.144 | 0.207 | 0.091 | 19319362 | 3598421 | 6024286 | 517179 | 0.231 | 0.043 | 0.072 | 0.006 | 414821005 | 30578797 | 37457915 | 9663634 | 1797165 | 104999032656 | 3043.478 | 387583597 | 11.234 | 558677.1 | 156.786 | 0.006 | 26066.59 | 143.955 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S1a | 37195208 | 87015658430 | 2339.432 | 466968792 | 12.555 | 20352.83 | 289.039 | -| S3b | 17247748 | 53304765553 | 3090.535 | 193842443 | 11.239 | 20929.02 | 281.433 | -| S2a | 22083208 | 62093405681 | 2811.793 | 271120515 | 12.277 | 21786.54 | 204.440 | -| S3c | 17255289 | 52372898312 | 3035.179 | 193880135 | 11.236 | 21176.66 | 200.429 | -| S3d | 17249786 | 52605759305 | 3049.647 | 193811771 | 11.236 | 24596.88 | 167.025 | -| S1b | 37197852 | 85019682451 | 2285.607 | 466815725 | 12.550 | 30493.80 | 92.498 | -| S1c | 37186225 | 85476215421 | 2298.599 | 466624752 | 12.548 | 44640.36 | 18.921 | -| S1NoCD | 37191950 | 79628195883 | 2141.006 | 466565294 | 12.545 | NaN | 0.000 | -| S2NoCD | 22087417 | 58618311506 | 2653.923 | 271012140 | 12.270 | NaN | 0.000 | -| S3NoCD | 17252656 | 49824346254 | 2887.923 | 193730581 | 11.229 | NaN | 0.000 | -| S3a | 17243481 | 51742662653 | 3000.709 | 193656912 | 11.231 | 66246.23 | \-27.660 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S3b | 34499019 | 106572608911 | 3089.149 | 387784278 | 11.240 | 16805.46 | 399.897 | +| S1a | 74386358 | 174028848972 | 2339.526 | 933898758 | 12.555 | 18392.33 | 341.194 | +| S2a | 44167644 | 124138133751 | 2810.613 | 542293812 | 12.278 | 17005.48 | 300.888 | +| S3c | 34498158 | 104673766491 | 3034.184 | 387592275 | 11.235 | 21811.80 | 190.609 | +| S3d | 34499680 | 104999032656 | 3043.478 | 387583597 | 11.234 | 26066.59 | 143.955 | +| S3a | 34502959 | 103657451678 | 3004.306 | 387588700 | 11.233 | 23083.96 | 137.138 | +| S1b | 74391545 | 169947664017 | 2284.502 | 933536456 | 12.549 | 28424.02 | 108.939 | +| S1c | 74393824 | 171127045501 | 2300.286 | 933458732 | 12.548 | 44006.44 | 21.696 | +| S1NoCD | 74394066 | 159276748461 | 2140.987 | 933192471 | 12.544 | NaN | 0.000 | +| S2NoCD | 44157584 | 117261957083 | 2655.534 | 541767607 | 12.269 | NaN | 0.000 | +| S3NoCD | 34503305 | 99600427724 | 2886.692 | 387416791 | 11.228 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | -| S1NoCDAvg | 37198402 | 1.0000000 | 79611221702 | 2140.179 | 0.000 | 2140.179 | 466612084 | 12.54387 | 0.00000 | 12.54387 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | -| S1a | 37195208 | 1.0000000 | 87015658430 | 2339.432 | 0.000 | 2339.432 | 466968792 | 12.55454 | 0.00000 | 12.55454 | 199.25342 | 0.0106673 | 18678.89 | 20352.82 | 334.11170 | -| S1b | 37197852 | 1.0000000 | 85019682451 | 2285.607 | 0.000 | 2285.607 | 466815725 | 12.54953 | 0.00000 | 12.54953 | 145.42877 | 0.0056600 | 25694.18 | 30493.80 | 137.57062 | -| S1c | 37186225 | 1.0000000 | 85476215421 | 2298.599 | 0.000 | 2298.599 | 466624752 | 12.54832 | 0.00000 | 12.54832 | 158.42035 | 0.0044483 | 35613.86 | 44640.36 | 63.99355 | -| S2NoCD | 22087417 | 0.5937733 | 58618311506 | 2653.923 | 1389.248 | 2140.179 | 271012140 | 12.26998 | 12.94422 | 12.54387 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | -| S2a | 22083208 | 0.5936601 | 62093405681 | 2811.793 | 1389.248 | 2233.756 | 271120515 | 12.27723 | 12.94422 | 12.54825 | 93.57772 | 0.0043781 | 21374.21 | 21786.54 | 125.32559 | -| S3NoCD | 17252656 | 0.4638010 | 49824346254 | 2887.923 | 1493.395 | 2140.179 | 193730581 | 11.22903 | 13.68119 | 12.54387 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | -| S3a | 17243481 | 0.4635543 | 51742662653 | 3000.709 | 1493.395 | 2192.117 | 193656912 | 11.23073 | 13.68119 | 12.54527 | 51.93821 | 0.0013940 | 37257.45 | 66246.23 | 17.76357 | -| S3b | 17247748 | 0.4636691 | 53304765553 | 3090.535 | 1493.395 | 2233.939 | 193842443 | 11.23871 | 13.68119 | 12.54869 | 93.76072 | 0.0048123 | 19483.67 | 20929.02 | 146.85282 | -| S3c | 17255289 | 0.4638718 | 52372898312 | 3035.179 | 1493.395 | 2208.585 | 193880135 | 11.23598 | 13.68119 | 12.54693 | 68.40670 | 0.0030521 | 22413.32 | 21176.66 | 84.19609 | -| S3d | 17249786 | 0.4637238 | 52605759305 | 3049.647 | 1493.395 | 2215.066 | 193811771 | 11.23560 | 13.68119 | 12.54711 | 74.88760 | 0.0032382 | 23126.56 | 24596.89 | 87.02063 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | +| S1NoCDAvg | 74395846 | 1.0000000 | 159200698335 | 2139.914 | 0.000 | 2139.914 | 933196561 | 12.54367 | 0.00000 | 12.54367 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | +| S1a | 74386358 | 1.0000000 | 174028848972 | 2339.526 | 0.000 | 2339.526 | 933898758 | 12.55470 | 0.00000 | 12.55470 | 199.61258 | 0.0110397 | 18081.28 | 18392.33 | 352.3742441 | +| S1b | 74391545 | 1.0000000 | 169947664017 | 2284.502 | 0.000 | 2284.502 | 933536456 | 12.54896 | 0.00000 | 12.54896 | 144.58859 | 0.0052941 | 27311.04 | 28424.02 | 120.1185902 | +| S1c | 74393824 | 1.0000000 | 171127045501 | 2300.286 | 0.000 | 2300.286 | 933458732 | 12.54753 | 0.00000 | 12.54753 | 160.37182 | 0.0038650 | 41493.86 | 44006.44 | 32.8758142 | +| S2NoCD | 44157584 | 0.5935491 | 117261957083 | 2655.534 | 1386.943 | 2139.914 | 541767607 | 12.26896 | 12.94482 | 12.54366 | 0.00000 | 0.0000000 | NaN | NaN | \-0.0042008 | +| S2a | 44167644 | 0.5936843 | 124138133751 | 2810.613 | 1386.943 | 2232.153 | 542293812 | 12.27808 | 12.94482 | 12.54899 | 92.23934 | 0.0053226 | 17329.70 | 17005.48 | 173.8872461 | +| S3NoCD | 34503305 | 0.4637800 | 99600427724 | 2886.692 | 1494.020 | 2139.914 | 387416791 | 11.22840 | 13.68125 | 12.54366 | 0.00000 | 0.0000000 | NaN | NaN | \-0.0042008 | +| S3a | 34502959 | 0.4637753 | 103657451678 | 3004.306 | 1494.020 | 2194.454 | 387588700 | 11.23349 | 13.68125 | 12.54604 | 54.53988 | 0.0023744 | 22970.32 | 23083.96 | 64.1740583 | +| S3b | 34499019 | 0.4637224 | 106572608911 | 3089.149 | 1494.020 | 2233.717 | 387784278 | 11.24044 | 13.68125 | 12.54939 | 93.80342 | 0.0057278 | 16376.84 | 16805.46 | 192.5827814 | +| S3c | 34498158 | 0.4637108 | 104673766491 | 3034.184 | 1494.020 | 2208.211 | 387592275 | 11.23516 | 13.68125 | 12.54697 | 68.29721 | 0.0033053 | 20662.82 | 21811.80 | 96.9645594 | +| S3d | 34499680 | 0.4637313 | 104999032656 | 3043.478 | 1494.020 | 2212.553 | 387583597 | 11.23441 | 13.68125 | 12.54657 | 72.63874 | 0.0029088 | 24972.23 | 26066.59 | 72.7961203 | ![](../../outputs/Sen1_No_Smoking_Cessation_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190548 | 0.1354468 | 0.1513316 | 0.0796706 | 0.4145764 | 0.0774588 | 0.1302929 | 0.0112391 | 0.8425251 | 0.0461019 | 0.0491004 | 0.0110213 | 0.0019123 | 0.1861941 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0278482 | 0.1534250 | 0.2729629 | 0.0908525 | 0.4049232 | 0.0759127 | 0.1279467 | 0.0110439 | 0.8423737 | 0.0460814 | 0.0491933 | 0.0110760 | 0.0019339 | 0.4002441 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240917 | 0.1446612 | 0.2158567 | 0.0855915 | 0.4086463 | 0.0766199 | 0.1292126 | 0.0111613 | 0.8424395 | 0.0461279 | 0.0491244 | 0.0110415 | 0.0019202 | 0.2944328 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229833 | 0.1415680 | 0.1958915 | 0.0835702 | 0.4106125 | 0.0769541 | 0.1293862 | 0.0111547 | 0.8424799 | 0.0460774 | 0.0491224 | 0.0110557 | 0.0019205 | 0.2602346 | -| S2NoCD | 0.5937733 | 0.5825448 | 0.7051505 | 0.0190548 | 0.1354468 | 0.1513316 | 0.0796706 | 0.4145764 | 0.0774588 | 0.1302929 | 0.0112391 | 0.8425251 | 0.0461019 | 0.0491004 | 0.0110213 | 0.0019123 | 0.1861941 | -| S2a | 0.5936601 | 0.5824633 | 0.7058883 | 0.0214490 | 0.1434612 | 0.2091222 | 0.0849061 | 0.4099831 | 0.0767959 | 0.1293722 | 0.0111234 | 0.8424382 | 0.0460994 | 0.0491376 | 0.0110580 | 0.0019273 | 0.2777966 | -| S3NoCD | 0.4638010 | 0.4155176 | 0.5869005 | 0.0190548 | 0.1354468 | 0.1513316 | 0.0796706 | 0.4145764 | 0.0774588 | 0.1302929 | 0.0112391 | 0.8425251 | 0.0461019 | 0.0491004 | 0.0110213 | 0.0019123 | 0.1861941 | -| S3a | 0.4635543 | 0.4152258 | 0.5858992 | 0.0198466 | 0.1380536 | 0.1714739 | 0.0814649 | 0.4120962 | 0.0770690 | 0.1297838 | 0.0111967 | 0.8426079 | 0.0460823 | 0.0490677 | 0.0109955 | 0.0019044 | 0.2173022 | -| S3b | 0.4636691 | 0.4154062 | 0.5875593 | 0.0217858 | 0.1440359 | 0.2125182 | 0.0853803 | 0.4090993 | 0.0766788 | 0.1290683 | 0.0111479 | 0.8424404 | 0.0461319 | 0.0491416 | 0.0110236 | 0.0019187 | 0.2843963 | -| S3c | 0.4638718 | 0.4156059 | 0.5872253 | 0.0207519 | 0.1409237 | 0.1914211 | 0.0833727 | 0.4107829 | 0.0769046 | 0.1294822 | 0.0111861 | 0.8424983 | 0.0461108 | 0.0491177 | 0.0110183 | 0.0019139 | 0.2494955 | -| S3d | 0.4637238 | 0.4155174 | 0.5871943 | 0.0203062 | 0.1397428 | 0.1825038 | 0.0825487 | 0.4115494 | 0.0770272 | 0.1297507 | 0.0112166 | 0.8424927 | 0.0461004 | 0.0491311 | 0.0110236 | 0.0019130 | 0.2346429 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190473 | 0.1352836 | 0.1511410 | 0.0795532 | 0.4148239 | 0.0774716 | 0.1302600 | 0.0112363 | 0.8424855 | 0.0461135 | 0.0491144 | 0.0110302 | 0.0019157 | 0.1860255 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0278123 | 0.1534482 | 0.2729249 | 0.0907984 | 0.4043988 | 0.0757927 | 0.1279905 | 0.0110865 | 0.8424205 | 0.0460794 | 0.0491822 | 0.0110529 | 0.0019210 | 0.3999629 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240696 | 0.1444335 | 0.2155905 | 0.0853753 | 0.4089365 | 0.0765707 | 0.1291232 | 0.0111708 | 0.8424242 | 0.0461088 | 0.0491641 | 0.0110416 | 0.0019161 | 0.2943312 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229703 | 0.1416387 | 0.1958173 | 0.0837379 | 0.4108070 | 0.0768670 | 0.1295169 | 0.0111924 | 0.8424570 | 0.0461103 | 0.0491327 | 0.0110409 | 0.0019185 | 0.2601382 | +| S2NoCD | 0.5935491 | 0.5822859 | 0.7045730 | 0.0190473 | 0.1352836 | 0.1511410 | 0.0795532 | 0.4148239 | 0.0774716 | 0.1302600 | 0.0112363 | 0.8424855 | 0.0461135 | 0.0491144 | 0.0110302 | 0.0019157 | 0.1860255 | +| S2a | 0.5936843 | 0.5825303 | 0.7054725 | 0.0214502 | 0.1431169 | 0.2087483 | 0.0847761 | 0.4102138 | 0.0767836 | 0.1292283 | 0.0111333 | 0.8424082 | 0.0461225 | 0.0491492 | 0.0110491 | 0.0019299 | 0.2776421 | +| S3NoCD | 0.4637800 | 0.4154805 | 0.5868857 | 0.0190473 | 0.1352836 | 0.1511410 | 0.0795532 | 0.4148239 | 0.0774716 | 0.1302600 | 0.0112363 | 0.8424855 | 0.0461135 | 0.0491144 | 0.0110302 | 0.0019157 | 0.1860255 | +| S3a | 0.4637753 | 0.4155463 | 0.5864758 | 0.0198255 | 0.1379490 | 0.1715213 | 0.0813847 | 0.4126801 | 0.0771648 | 0.1298649 | 0.0112170 | 0.8425337 | 0.0460773 | 0.0490779 | 0.0110497 | 0.0019187 | 0.2172724 | +| S3b | 0.4637224 | 0.4155225 | 0.5870019 | 0.0217642 | 0.1436251 | 0.2121273 | 0.0851968 | 0.4092275 | 0.0766039 | 0.1290548 | 0.0111542 | 0.8424740 | 0.0460883 | 0.0491108 | 0.0110571 | 0.0019271 | 0.2841958 | +| S3c | 0.4637108 | 0.4154317 | 0.5865508 | 0.0207095 | 0.1407425 | 0.1915385 | 0.0832853 | 0.4108399 | 0.0768743 | 0.1294800 | 0.0111750 | 0.8425156 | 0.0460917 | 0.0490917 | 0.0110393 | 0.0019180 | 0.2494870 | +| S3d | 0.4637313 | 0.4154792 | 0.5866348 | 0.0202886 | 0.1393272 | 0.1821778 | 0.0823358 | 0.4114549 | 0.0769170 | 0.1295782 | 0.0111900 | 0.8425103 | 0.0460827 | 0.0490966 | 0.0110498 | 0.0019161 | 0.2344668 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 14.48371 hours + ## Time difference of 1.361881 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence3yrs.md index a3434b3..dc8ca2c 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 50% Medication Adherence ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466614758 | 12.545 | 625082.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466676159 | 12.546 | 625142.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466645458 | 12.545 | 625112.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195779 | 626218800 | 71281372 | 186100281 | 33119195 | 13388772 | 0.026 | 0.159 | 0.310 | 0.094 | 14905588 | 2814123 | 4756454 | 412031 | 0.209 | 0.039 | 0.067 | 0.006 | 527524487 | 28873365 | 30786968 | 6925999 | 1208772 | 90753454326 | 2439.886 | 467242138 | 12.562 | 625645.0 | 292.777 | 0.017 | 17116.09 | 562.492 | -| S1b | 37200476 | 626144172 | 71252445 | 188422793 | 23802097 | 13372758 | 0.022 | 0.148 | 0.240 | 0.088 | 15103031 | 2841048 | 4796549 | 415612 | 0.212 | 0.040 | 0.067 | 0.006 | 527481440 | 28877807 | 30767692 | 6915814 | 1204950 | 87878153022 | 2362.286 | 466988044 | 12.553 | 625301.8 | 215.177 | 0.009 | 24764.46 | 219.270 | -| S1c | 37192813 | 625960445 | 71159107 | 189176712 | 20537777 | 13372239 | 0.020 | 0.144 | 0.214 | 0.085 | 15172732 | 2850944 | 4816068 | 416845 | 0.213 | 0.040 | 0.068 | 0.006 | 527395566 | 28830750 | 30734973 | 6903078 | 1206962 | 88797560537 | 2387.492 | 466783360 | 12.550 | 625130.7 | 240.384 | 0.006 | 41646.33 | 48.218 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 933216569 | 12.545 | 625108.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 933263557 | 12.546 | 625139.1 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 933240063 | 12.545 | 625123.8 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74380275 | 1252107231 | 142568770 | 372100831 | 66270673 | 26745802 | 0.026 | 0.159 | 0.310 | 0.094 | 29815042 | 5625494 | 9500837 | 824680.0 | 0.209 | 0.039 | 0.067 | 0.006 | 1054730269 | 57758498 | 61574433 | 13835312 | 2423951 | 181401075128 | 2438.833 | 934239602 | 12.560 | 625576.9 | 290.796 | 0.015 | 19152.73 | 468.354 | +| S1b | 74383024 | 1252030978 | 142410670 | 376764647 | 47607118 | 26748888 | 0.022 | 0.148 | 0.241 | 0.088 | 30192660 | 5683507 | 9596337 | 830158.0 | 0.212 | 0.040 | 0.067 | 0.006 | 1054810413 | 57710159 | 61499603 | 13827904 | 2405886 | 175747140584 | 2362.732 | 933787724 | 12.554 | 625326.0 | 214.694 | 0.009 | 24838.03 | 217.495 | +| S1c | 74393892 | 1252166867 | 142379318 | 378416895 | 41063274 | 26758496 | 0.020 | 0.144 | 0.214 | 0.085 | 30350312 | 5702044 | 9621386 | 828456.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054965444 | 57726777 | 61483651 | 13803995 | 2400849 | 177409072797 | 2384.726 | 933746980 | 12.551 | 625184.9 | 236.689 | 0.006 | 37796.71 | 76.419 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ----: | -------------: | -| S2NoCD | 22078563 | 364522749 | 50166624 | 110968095 | 9653606 | 7738507 | 0.017 | 0.141 | 0.159 | 0.087 | 11438971 | 2125413 | 3543389 | 304919 | 0.228 | 0.042 | 0.071 | 0.006 | 298790021 | 18633807 | 22502661 | 5543543 | 1025792 | 58731887921 | 2660.132 | 270917818 | 12.271 | 610871.2 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077788 | 364622606 | 50226923 | 108797477 | 18511084 | 7734136 | 0.023 | 0.157 | 0.269 | 0.097 | 11192847 | 2087413 | 3500787 | 300763 | 0.223 | 0.042 | 0.070 | 0.006 | 298828425 | 18622586 | 22524521 | 5579724 | 1036307 | 63840415723 | 2891.613 | 271190365 | 12.283 | 611278.5 | 231.481 | 0.013 | 18119 | 407.299 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ------: | -------------: | +| S2NoCD | 44156404 | 729084497 | 100330760 | 221928932 | 19330952 | 15481473 | 0.017 | 0.142 | 0.159 | 0.087 | 22917076 | 4253860 | 7098458 | 609501 | 0.228 | 0.042 | 0.071 | 0.006 | 597619551 | 37246010 | 44990133 | 11123560 | 2050468 | 117605933755 | 2663.395 | 541859031 | 12.271 | 610904.5 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44164773 | 729329891 | 100492049 | 217625447 | 37010683 | 15485858 | 0.023 | 0.157 | 0.269 | 0.097 | 22383331 | 4181008 | 7006346 | 603148 | 0.223 | 0.042 | 0.070 | 0.006 | 597700094 | 37284225 | 45068617 | 11147317 | 2064302 | 127735308298 | 2892.244 | 542449119 | 12.282 | 611227.4 | 228.849 | 0.011 | 20737.2 | 322.935 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17243525 | 260017880 | 41691838 | 80059027 | 7819384 | 5815322 | 0.018 | 0.137 | 0.154 | 0.086 | 9754415 | 1816466 | 3038101 | 261338 | 0.234 | 0.044 | 0.073 | 0.006 | 207433146 | 15294590 | 18682841 | 4808648 | 895345 | 49933527334 | 2895.784 | 193676014 | 11.232 | 558694.8 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17245589 | 260114351 | 41778508 | 79305268 | 11012874 | 5816924 | 0.021 | 0.144 | 0.204 | 0.091 | 9648241 | 1803612 | 3027939 | 260144 | 0.231 | 0.043 | 0.072 | 0.006 | 207442211 | 15303706 | 18733677 | 4824249 | 900624 | 53097071421 | 3078.878 | 193814317 | 11.238 | 558845.4 | 183.094 | 0.007 | 27428.51 | 150.672 | -| S3b | 17248093 | 260143539 | 41765340 | 77789956 | 17179218 | 5809490 | 0.027 | 0.156 | 0.293 | 0.099 | 9481831 | 1779958 | 2992091 | 258625 | 0.227 | 0.043 | 0.072 | 0.006 | 207483725 | 15287322 | 18724587 | 4837601 | 899769 | 55163743515 | 3198.252 | 193983110 | 11.247 | 559133.8 | 302.468 | 0.015 | 20395.72 | 439.030 | -| S3c | 17249568 | 260123652 | 41796963 | 78552778 | 14093542 | 5811921 | 0.024 | 0.150 | 0.249 | 0.095 | 9556493 | 1794042 | 3007246 | 258985 | 0.229 | 0.043 | 0.072 | 0.006 | 207434647 | 15324709 | 18727689 | 4823824 | 902793 | 53820717606 | 3120.120 | 193896397 | 11.241 | 558912.5 | 224.336 | 0.009 | 25373.54 | 217.730 | -| S3d | 17250373 | 260166499 | 41788451 | 78909896 | 12694599 | 5812281 | 0.023 | 0.147 | 0.229 | 0.093 | 9596955 | 1798651 | 3013620 | 260246 | 0.230 | 0.043 | 0.072 | 0.006 | 207483596 | 15310784 | 18731510 | 4829309 | 900292 | 54140141633 | 3138.491 | 193895422 | 11.240 | 558865.1 | 242.707 | 0.008 | 29382.46 | 170.306 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34500334 | 520264617 | 83469550 | 160191877 | 15617539 | 11630123 | 0.018 | 0.137 | 0.154 | 0.086 | 19525292 | 3631989 | 6073558 | 522424 | 0.234 | 0.044 | 0.073 | 0.006 | 415002016 | 30608834 | 37422882 | 9624470 | 1788687 | 99842281258 | 2893.951 | 387517176 | 11.232 | 558719.7 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34507415 | 520428951 | 83482576 | 158676520 | 22030098 | 11639538 | 0.021 | 0.144 | 0.204 | 0.091 | 19287934 | 3609226 | 6045313 | 521405 | 0.231 | 0.043 | 0.072 | 0.006 | 415152628 | 30610103 | 37407716 | 9641236 | 1794702 | 106095806862 | 3074.580 | 387796823 | 11.238 | 558829.0 | 180.629 | 0.006 | 31147.82 | 109.325 | +| S3b | 34499539 | 520396932 | 83618002 | 155590263 | 34428826 | 11625591 | 0.027 | 0.156 | 0.293 | 0.099 | 18988453 | 3564625 | 5980823 | 516662 | 0.227 | 0.043 | 0.072 | 0.006 | 414988556 | 30607762 | 37472866 | 9688489 | 1813970 | 110363699543 | 3198.991 | 388038736 | 11.248 | 559183.5 | 305.039 | 0.015 | 19837.73 | 463.797 | +| S3c | 34496334 | 520227370 | 83568351 | 157099275 | 28171361 | 11622564 | 0.024 | 0.150 | 0.249 | 0.095 | 19145218 | 3585036 | 6010150 | 518449 | 0.229 | 0.043 | 0.072 | 0.006 | 414875686 | 30589301 | 37479876 | 9661353 | 1804425 | 107627143927 | 3119.959 | 387776879 | 11.241 | 558935.2 | 226.008 | 0.009 | 25592.92 | 215.536 | +| S3d | 34507664 | 520495018 | 83555471 | 157877292 | 25364366 | 11630839 | 0.023 | 0.147 | 0.229 | 0.093 | 19209915 | 3595849 | 6028084 | 520340 | 0.230 | 0.043 | 0.072 | 0.006 | 415141325 | 30594930 | 37472224 | 9653084 | 1805226 | 108255487965 | 3137.143 | 387911628 | 11.241 | 558928.8 | 243.192 | 0.009 | 26887.15 | 209.054 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S1a | 37195779 | 90753454326 | 2439.886 | 467242138 | 12.562 | 17116.09 | 562.492 | -| S3b | 17248093 | 55163743515 | 3198.252 | 193983110 | 11.247 | 20395.72 | 439.030 | -| S2a | 22077788 | 63840415723 | 2891.613 | 271190365 | 12.283 | 18119.00 | 407.299 | -| S1b | 37200476 | 87878153022 | 2362.286 | 466988044 | 12.553 | 24764.46 | 219.270 | -| S3c | 17249568 | 53820717606 | 3120.120 | 193896397 | 11.241 | 25373.54 | 217.730 | -| S3d | 17250373 | 54140141633 | 3138.491 | 193895422 | 11.240 | 29382.46 | 170.306 | -| S3a | 17245589 | 53097071421 | 3078.878 | 193814317 | 11.238 | 27428.51 | 150.672 | -| S1c | 37192813 | 88797560537 | 2387.492 | 466783360 | 12.550 | 41646.33 | 48.218 | -| S1NoCD | 37196486 | 79864892645 | 2147.109 | 466614758 | 12.545 | NaN | 0.000 | -| S2NoCD | 22078563 | 58731887921 | 2660.132 | 270917818 | 12.271 | NaN | 0.000 | -| S3NoCD | 17243525 | 49933527334 | 2895.784 | 193676014 | 11.232 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S1a | 74380275 | 181401075128 | 2438.833 | 934239602 | 12.560 | 19152.73 | 468.354 | +| S3b | 34499539 | 110363699543 | 3198.991 | 388038736 | 11.248 | 19837.73 | 463.797 | +| S2a | 44164773 | 127735308298 | 2892.244 | 542449119 | 12.282 | 20737.20 | 322.935 | +| S1b | 74383024 | 175747140584 | 2362.732 | 933787724 | 12.554 | 24838.03 | 217.495 | +| S3c | 34496334 | 107627143927 | 3119.959 | 387776879 | 11.241 | 25592.92 | 215.536 | +| S3d | 34507664 | 108255487965 | 3137.143 | 387911628 | 11.241 | 26887.15 | 209.054 | +| S3a | 34507415 | 106095806862 | 3074.580 | 387796823 | 11.238 | 31147.82 | 109.325 | +| S1c | 74393892 | 177409072797 | 2384.726 | 933746980 | 12.551 | 37796.71 | 76.419 | +| S1NoCD | 74388747 | 159789813678 | 2148.037 | 933216569 | 12.545 | NaN | 0.000 | +| S2NoCD | 44156404 | 117605933755 | 2663.395 | 541859031 | 12.271 | NaN | 0.000 | +| S3NoCD | 34500334 | 99842281258 | 2893.951 | 387517176 | 11.232 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466645458 | 12.54523 | 0.00000 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37195779 | 1.0000000 | 90753454326 | 2439.886 | 0.000 | 2439.886 | 467242138 | 12.56170 | 0.00000 | 12.56170 | 291.04522 | 0.0164718 | 17669.33 | 17116.09 | 532.5435790 | -| S1b | 37200476 | 1.0000000 | 87878153022 | 2362.286 | 0.000 | 2362.286 | 466988044 | 12.55328 | 0.00000 | 12.55328 | 213.44510 | 0.0080553 | 26497.34 | 24764.46 | 189.3218597 | -| S1c | 37192813 | 1.0000000 | 88797560537 | 2387.492 | 0.000 | 2387.492 | 466783360 | 12.55036 | 0.00000 | 12.55036 | 238.65184 | 0.0051384 | 46444.60 | 41646.33 | 18.2691463 | -| S2NoCD | 22078563 | 0.5935568 | 58731887921 | 2660.132 | 1402.167 | 2148.841 | 270917818 | 12.27063 | 12.94624 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S2a | 22077788 | 0.5935359 | 63840415723 | 2891.613 | 1402.167 | 2286.207 | 271190365 | 12.28340 | 12.94624 | 12.55282 | 137.36611 | 0.0075969 | 18081.98 | 18119.00 | 242.4848714 | -| S3NoCD | 17243525 | 0.4635723 | 49933527334 | 2895.784 | 1503.344 | 2148.841 | 193676014 | 11.23181 | 13.68026 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S3a | 17245589 | 0.4636278 | 53097071421 | 3078.878 | 1503.344 | 2233.805 | 193814317 | 11.23849 | 13.68026 | 12.54819 | 84.96483 | 0.0029590 | 28713.97 | 27428.51 | 62.9938915 | -| S3b | 17248093 | 0.4636951 | 55163743515 | 3198.252 | 1503.344 | 2289.264 | 193983110 | 11.24664 | 13.68026 | 12.55180 | 140.42373 | 0.0065759 | 21354.32 | 20395.72 | 188.3794023 | -| S3c | 17249568 | 0.4637348 | 53820717606 | 3120.120 | 1503.344 | 2253.099 | 193896397 | 11.24065 | 13.68026 | 12.54893 | 104.25841 | 0.0037023 | 28160.79 | 25373.54 | 80.8627246 | -| S3d | 17250373 | 0.4637564 | 54140141633 | 3138.491 | 1503.344 | 2261.654 | 193895422 | 11.24007 | 13.68026 | 12.54861 | 112.81322 | 0.0033800 | 33376.80 | 29382.46 | 56.1946409 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 933240063 | 12.54547 | 0.00000 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74380275 | 1.0000000 | 181401075128 | 2438.833 | 0.000 | 2438.833 | 934239602 | 12.56031 | 0.00000 | 12.56031 | 288.96609 | 0.0148400 | 19472.10 | 19152.73 | 453.03421 | +| S1b | 74383024 | 1.0000000 | 175747140584 | 2362.732 | 0.000 | 2362.732 | 933787724 | 12.55377 | 0.00000 | 12.55377 | 212.86487 | 0.0083008 | 25643.89 | 24838.02 | 202.17518 | +| S1c | 74393892 | 1.0000000 | 177409072797 | 2384.726 | 0.000 | 2384.726 | 933746980 | 12.55139 | 0.00000 | 12.55139 | 234.85933 | 0.0059192 | 39677.70 | 37796.70 | 61.09955 | +| S2NoCD | 44156404 | 0.5935911 | 117605933755 | 2663.395 | 1399.821 | 2149.867 | 541859031 | 12.27136 | 12.94584 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44164773 | 0.5937036 | 127735308298 | 2892.244 | 1399.821 | 2285.878 | 542449119 | 12.28239 | 12.94584 | 12.55195 | 136.01091 | 0.0064761 | 21002.14 | 20737.20 | 187.79161 | +| S3NoCD | 34500334 | 0.4637853 | 99842281258 | 2893.951 | 1506.290 | 2149.867 | 387517176 | 11.23227 | 13.68129 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34507415 | 0.4638805 | 106095806862 | 3074.580 | 1506.290 | 2233.789 | 387796823 | 11.23807 | 13.68129 | 12.54793 | 83.92228 | 0.0024570 | 34156.94 | 31147.82 | 38.92579 | +| S3b | 34499539 | 0.4637746 | 110363699543 | 3198.991 | 1506.290 | 2291.322 | 388038736 | 11.24765 | 13.68129 | 12.55263 | 141.45471 | 0.0071575 | 19763.12 | 19837.73 | 216.42072 | +| S3c | 34496334 | 0.4637315 | 107627143927 | 3119.959 | 1506.290 | 2254.599 | 387776879 | 11.24110 | 13.68129 | 12.54970 | 104.73230 | 0.0042268 | 24777.92 | 25592.93 | 106.60970 | +| S3d | 34507664 | 0.4638839 | 108255487965 | 3137.143 | 1506.290 | 2262.817 | 387911628 | 11.24132 | 13.68129 | 12.54943 | 112.94966 | 0.0039545 | 28562.49 | 26887.15 | 84.77408 | ![](../../outputs/Sen2_50_Med_Adherence_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264130 | 0.1594355 | 0.3100498 | 0.0943012 | 0.4007333 | 0.0756571 | 0.1278762 | 0.0110774 | 0.8423964 | 0.0461075 | 0.0491633 | 0.0110600 | 0.0019303 | 0.4646262 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216055 | 0.1480604 | 0.2404960 | 0.0875941 | 0.4059903 | 0.0763713 | 0.1289378 | 0.0111722 | 0.8424281 | 0.0461201 | 0.0491384 | 0.0110451 | 0.0019244 | 0.3340531 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201493 | 0.1442413 | 0.2143855 | 0.0852093 | 0.4079480 | 0.0766531 | 0.1294892 | 0.0112077 | 0.8425382 | 0.0460584 | 0.0491005 | 0.0110280 | 0.0019282 | 0.2886177 | -| S2NoCD | 0.5935568 | 0.5823097 | 0.7053578 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935359 | 0.5824692 | 0.7062056 | 0.0223351 | 0.1468614 | 0.2290467 | 0.0868672 | 0.4071715 | 0.0764348 | 0.1292457 | 0.0111517 | 0.8425215 | 0.0460676 | 0.0490957 | 0.0110473 | 0.0019254 | 0.3104013 | -| S3NoCD | 0.4635723 | 0.4153676 | 0.5861997 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4636278 | 0.4155217 | 0.5874183 | 0.0201358 | 0.1392626 | 0.1805149 | 0.0822287 | 0.4109128 | 0.0771069 | 0.1301110 | 0.0112307 | 0.8424794 | 0.0461006 | 0.0491419 | 0.0110143 | 0.0019170 | 0.2306846 | -| S3b | 0.4636951 | 0.4155683 | 0.5872332 | 0.0226883 | 0.1466743 | 0.2326983 | 0.0870001 | 0.4064201 | 0.0764674 | 0.1291411 | 0.0111894 | 0.8425049 | 0.0460727 | 0.0491259 | 0.0110354 | 0.0019156 | 0.3174192 | -| S3c | 0.4637348 | 0.4155365 | 0.5876778 | 0.0213351 | 0.1429510 | 0.2072023 | 0.0845726 | 0.4084161 | 0.0768439 | 0.1295450 | 0.0111987 | 0.8424543 | 0.0461336 | 0.0491319 | 0.0110136 | 0.0019205 | 0.2739520 | -| S3d | 0.4637564 | 0.4156050 | 0.5875581 | 0.0207664 | 0.1413812 | 0.1952106 | 0.0835996 | 0.4094977 | 0.0769666 | 0.1297144 | 0.0112325 | 0.8424726 | 0.0461088 | 0.0491357 | 0.0110219 | 0.0019164 | 0.2543044 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264033 | 0.1593018 | 0.3099946 | 0.0940914 | 0.4008461 | 0.0756315 | 0.1277333 | 0.0110873 | 0.8423642 | 0.0461290 | 0.0491766 | 0.0110496 | 0.0019359 | 0.4648330 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216398 | 0.1482342 | 0.2406521 | 0.0877947 | 0.4059079 | 0.0764087 | 0.1290125 | 0.0111606 | 0.8424795 | 0.0460932 | 0.0491199 | 0.0110444 | 0.0019216 | 0.3342946 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201517 | 0.1441110 | 0.2141912 | 0.0851720 | 0.4079678 | 0.0766467 | 0.1293303 | 0.0111361 | 0.8425119 | 0.0461015 | 0.0491018 | 0.0110241 | 0.0019174 | 0.2884076 | +| S2NoCD | 0.5935911 | 0.5823656 | 0.7051165 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5937036 | 0.5825616 | 0.7062500 | 0.0223572 | 0.1465203 | 0.2287835 | 0.0867962 | 0.4069072 | 0.0764858 | 0.1291620 | 0.0111850 | 0.8424534 | 0.0460995 | 0.0491621 | 0.0110233 | 0.0019191 | 0.3102030 | +| S3NoCD | 0.4637853 | 0.4155681 | 0.5866172 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4638805 | 0.4156993 | 0.5867088 | 0.0201156 | 0.1395918 | 0.1808230 | 0.0824771 | 0.4108939 | 0.0771596 | 0.1300215 | 0.0112568 | 0.8425660 | 0.0460728 | 0.0490892 | 0.0110179 | 0.0019129 | 0.2311946 | +| S3b | 0.4637746 | 0.4156737 | 0.5876605 | 0.0227032 | 0.1471017 | 0.2332507 | 0.0873282 | 0.4068980 | 0.0765657 | 0.1291642 | 0.0111939 | 0.8424573 | 0.0460719 | 0.0491421 | 0.0110558 | 0.0019283 | 0.3181560 | +| S3c | 0.4637315 | 0.4155383 | 0.5873116 | 0.0213262 | 0.1432680 | 0.2074859 | 0.0848645 | 0.4090175 | 0.0768424 | 0.1295624 | 0.0112182 | 0.8424856 | 0.0460621 | 0.0491521 | 0.0110349 | 0.0019208 | 0.2742435 | +| S3d | 0.4638839 | 0.4157521 | 0.5872211 | 0.0207546 | 0.1415673 | 0.1954816 | 0.0837051 | 0.4098442 | 0.0769796 | 0.1297896 | 0.0112424 | 0.8425108 | 0.0460587 | 0.0491390 | 0.0110271 | 0.0019212 | 0.2545329 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 17.02702 hours + ## Time difference of 1.2965 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence5yrs.md index 9f95f32..749acf7 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen2_50_Med_Adherence5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 50% Medication Adherence ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD2 | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466614758 | 12.545 | 625082.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466676159 | 12.546 | 625142.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466645458 | 12.545 | 625112.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37197502 | 626089853 | 71222084 | 122776626 | 28487983 | 16327137 | 0.028 | 0.154 | 0.273 | 0.091 | 14992350 | 2827989 | 4776515 | 413886 | 0.211 | 0.040 | 0.067 | 0.006 | 527456443 | 28870190 | 30752817 | 6907934 | 1206659 | 87609315426 | 2355.247 | 467053611 | 12.556 | 625447.1 | 204.675 | 0.010 | 20089.64 | 304.729 | -| S1b | 37190655 | 625992698 | 71214502 | 123717512 | 20974578 | 16327973 | 0.024 | 0.145 | 0.216 | 0.086 | 15197291 | 2852978 | 4811387 | 417126 | 0.213 | 0.040 | 0.068 | 0.006 | 527372066 | 28861102 | 30747408 | 6915037 | 1207305 | 85474784067 | 2298.287 | 466807667 | 12.552 | 625289.0 | 147.714 | 0.006 | 25093.04 | 146.619 | -| S1c | 37195162 | 626110982 | 71210037 | 124047387 | 18535585 | 16324587 | 0.023 | 0.142 | 0.196 | 0.084 | 15221449 | 2863867 | 4834566 | 417049 | 0.214 | 0.040 | 0.068 | 0.006 | 527490541 | 28868640 | 30764128 | 6896850 | 1196858 | 86086185363 | 2314.446 | 466843147 | 12.551 | 625244.5 | 163.873 | 0.005 | 30805.50 | 102.107 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD2 | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 933216569 | 12.545 | 625108.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 933263557 | 12.546 | 625139.1 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 933240063 | 12.545 | 625123.8 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386318 | 1252092577 | 142511621 | 245523949 | 57058349 | 32655914 | 0.028 | 0.154 | 0.274 | 0.091 | 30028808 | 5656584 | 9558038 | 827432.0 | 0.211 | 0.040 | 0.067 | 0.006 | 1054768469 | 57752767 | 61521629 | 13851433 | 2413714 | 175298229824 | 2356.592 | 934033198 | 12.557 | 625469.3 | 204.896 | 0.011 | 19145.74 | 330.199 | +| S1b | 74385413 | 1252007176 | 142455061 | 247448362 | 41936466 | 32651747 | 0.024 | 0.145 | 0.216 | 0.086 | 30368698 | 5706469 | 9627370 | 832514.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054746061 | 57768304 | 61498391 | 13812986 | 2404656 | 170952563916 | 2298.200 | 933637487 | 12.551 | 625269.4 | 146.504 | 0.006 | 26468.96 | 130.242 | +| S1c | 74390720 | 1252048091 | 142295860 | 248074520 | 37009576 | 32668233 | 0.023 | 0.142 | 0.196 | 0.084 | 30456632 | 5715293 | 9646702 | 833108.0 | 0.214 | 0.040 | 0.068 | 0.006 | 1054933501 | 57690667 | 61453687 | 13794504 | 2396041 | 171904343832 | 2310.830 | 933570750 | 12.550 | 625167.1 | 159.134 | 0.004 | 42521.81 | 27.986 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22074342 | 364499893 | 50179989 | 72492409 | 9769650 | 9434235 | 0.021 | 0.142 | 0.160 | 0.087 | 11472370 | 2126666 | 3551252 | 304704 | 0.229 | 0.042 | 0.071 | 0.006 | 298757005 | 18626945 | 22501053 | 5562438 | 1027303 | 58922537505 | 2669.277 | 270895360 | 12.272 | 610928.5 | 0.0 | 0.000 | NaN | 0.000 | -| S2a | 22077777 | 364514086 | 50214779 | 71673455 | 16290550 | 9435494 | 0.025 | 0.153 | 0.241 | 0.095 | 11245330 | 2100490 | 3507989 | 302346 | 0.224 | 0.042 | 0.070 | 0.006 | 298734836 | 18629376 | 22530917 | 5562183 | 1028646 | 62347138314 | 2823.977 | 271063504 | 12.278 | 611059.2 | 154.7 | 0.006 | 27108.82 | 130.631 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44157029 | 729047563 | 100380900 | 145000421 | 19524492 | 18863743 | 0.021 | 0.142 | 0.160 | 0.087 | 22925265 | 4254784 | 7099566 | 609563 | 0.228 | 0.042 | 0.071 | 0.006 | 597538799 | 37245010 | 45040554 | 11117169 | 2054803 | 117807957835 | 2667.932 | 541828917 | 12.271 | 610857.2 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44154576 | 729145856 | 100448839 | 143361789 | 32595478 | 18878233 | 0.025 | 0.154 | 0.242 | 0.095 | 22519648 | 4200194 | 7025459 | 605531 | 0.224 | 0.042 | 0.070 | 0.006 | 597564735 | 37286040 | 45033303 | 11135908 | 2066352 | 124844786047 | 2827.448 | 542208652 | 12.280 | 611161.7 | 159.516 | 0.009 | 17185.88 | 304.575 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17254548 | 260185517 | 41753987 | 52456874 | 7922835 | 7061036 | 0.022 | 0.137 | 0.155 | 0.086 | 9767617 | 1818208 | 3040076 | 262205 | 0.234 | 0.044 | 0.073 | 0.006 | 207533583 | 15301679 | 18724752 | 4815426 | 897482 | 50064966233 | 2901.552 | 193797357 | 11.232 | 558681.9 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17251608 | 260177738 | 41735217 | 52193377 | 10112286 | 7056308 | 0.024 | 0.142 | 0.189 | 0.089 | 9673981 | 1809610 | 3026757 | 259927 | 0.232 | 0.043 | 0.073 | 0.006 | 207543323 | 15307443 | 18697708 | 4818609 | 897810 | 52066304895 | 3018.055 | 193847860 | 11.237 | 558807.4 | 116.503 | 0.005 | 24063.44 | 125.572 | -| S3b | 17246874 | 260180750 | 41770771 | 51592135 | 14901907 | 7060341 | 0.029 | 0.152 | 0.258 | 0.096 | 9537491 | 1786791 | 3000373 | 258790 | 0.228 | 0.043 | 0.072 | 0.006 | 207513062 | 15306657 | 18723252 | 4827550 | 898750 | 53626126689 | 3109.324 | 193956939 | 11.246 | 559186.6 | 207.773 | 0.014 | 14580.17 | 504.745 | -| S3c | 17246125 | 260144350 | 41792942 | 51894923 | 12432863 | 7060467 | 0.026 | 0.147 | 0.223 | 0.093 | 9621451 | 1801612 | 3014035 | 259735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459068 | 15294280 | 18748666 | 4834049 | 901039 | 52687996543 | 3055.063 | 193867414 | 11.241 | 559005.7 | 153.511 | 0.010 | 16078.26 | 323.876 | -| S3d | 17255729 | 260233694 | 41777900 | 52047317 | 11356970 | 7062160 | 0.025 | 0.144 | 0.207 | 0.091 | 9643777 | 1802264 | 3018596 | 260225 | 0.231 | 0.043 | 0.072 | 0.006 | 207557193 | 15328896 | 18715546 | 4823282 | 894293 | 52823751959 | 3061.230 | 193917114 | 11.238 | 558830.7 | 159.678 | 0.006 | 25873.76 | 148.893 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34491937 | 520096794 | 83394436 | 104866546 | 15798844 | 14116443 | 0.022 | 0.137 | 0.154 | 0.086 | 19479590 | 3630576 | 6075819 | 523166 | 0.234 | 0.044 | 0.073 | 0.006 | 414917152 | 30599570 | 37365292 | 9614469 | 1790750 | 99999943602 | 2899.227 | 387401839 | 11.232 | 558684.0 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34494037 | 520214111 | 83457293 | 104351592 | 20245608 | 14129448 | 0.024 | 0.142 | 0.189 | 0.089 | 19332282 | 3614629 | 6055063 | 518761 | 0.232 | 0.043 | 0.073 | 0.006 | 414968911 | 30599997 | 37426814 | 9615582 | 1787056 | 104115381916 | 3018.359 | 387590904 | 11.236 | 558804.7 | 119.132 | 0.005 | 24833.08 | 120.734 | +| S3b | 34509196 | 520537138 | 83620081 | 103218767 | 29823148 | 14132996 | 0.029 | 0.152 | 0.258 | 0.096 | 19135380 | 3582069 | 6004729 | 516649 | 0.229 | 0.043 | 0.072 | 0.006 | 415119150 | 30640730 | 37483240 | 9661621 | 1802895 | 107308147373 | 3109.552 | 388040453 | 11.245 | 559118.1 | 210.326 | 0.013 | 16319.03 | 434.092 | +| S3c | 34504471 | 520423616 | 83513343 | 103824096 | 24853847 | 14121585 | 0.026 | 0.146 | 0.223 | 0.093 | 19220385 | 3595075 | 6024956 | 518536 | 0.230 | 0.043 | 0.072 | 0.006 | 415113845 | 30619979 | 37421385 | 9639642 | 1802009 | 105270593424 | 3050.926 | 387852045 | 11.241 | 558980.7 | 151.699 | 0.009 | 16916.05 | 296.690 | +| S3d | 34501231 | 520389346 | 83507084 | 104079260 | 22711874 | 14135933 | 0.025 | 0.144 | 0.207 | 0.091 | 19266710 | 3605577 | 6035420 | 519637 | 0.231 | 0.043 | 0.072 | 0.006 | 415086795 | 30631737 | 37413709 | 9638221 | 1794998 | 105602366018 | 3060.829 | 387776869 | 11.240 | 558914.6 | 161.602 | 0.008 | 20600.86 | 230.620 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S3b | 17246874 | 53626126689 | 3109.324 | 193956939 | 11.246 | 14580.17 | 504.745 | -| S3c | 17246125 | 52687996543 | 3055.063 | 193867414 | 11.241 | 16078.26 | 323.876 | -| S1a | 37197502 | 87609315426 | 2355.247 | 467053611 | 12.556 | 20089.64 | 304.729 | -| S3d | 17255729 | 52823751959 | 3061.230 | 193917114 | 11.238 | 25873.76 | 148.893 | -| S1b | 37190655 | 85474784067 | 2298.287 | 466807667 | 12.552 | 25093.04 | 146.619 | -| S2a | 22077777 | 62347138314 | 2823.977 | 271063504 | 12.278 | 27108.82 | 130.631 | -| S3a | 17251608 | 52066304895 | 3018.055 | 193847860 | 11.237 | 24063.44 | 125.572 | -| S1c | 37195162 | 86086185363 | 2314.446 | 466843147 | 12.551 | 30805.50 | 102.107 | -| S1NoCD | 37197623 | 79996190237 | 2150.573 | 466676159 | 12.546 | NaN | 0.000 | -| S2NoCD | 22074342 | 58922537505 | 2669.277 | 270895360 | 12.272 | NaN | 0.000 | -| S3NoCD | 17254548 | 50064966233 | 2901.552 | 193797357 | 11.232 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S3b | 34509196 | 107308147373 | 3109.552 | 388040453 | 11.245 | 16319.03 | 434.092 | +| S1a | 74386318 | 175298229824 | 2356.592 | 934033198 | 12.557 | 19145.74 | 330.199 | +| S2a | 44154576 | 124844786047 | 2827.448 | 542208652 | 12.280 | 17185.88 | 304.575 | +| S3c | 34504471 | 105270593424 | 3050.926 | 387852045 | 11.241 | 16916.05 | 296.690 | +| S3d | 34501231 | 105602366018 | 3060.829 | 387776869 | 11.240 | 20600.86 | 230.620 | +| S1b | 74385413 | 170952563916 | 2298.200 | 933637487 | 12.551 | 26468.96 | 130.242 | +| S3a | 34494037 | 104115381916 | 3018.359 | 387590904 | 11.236 | 24833.08 | 120.734 | +| S1c | 74390720 | 171904343832 | 2310.830 | 933570750 | 12.550 | 42521.81 | 27.986 | +| S1NoCD | 74388425 | 160061317736 | 2151.697 | 933263557 | 12.546 | NaN | 0.000 | +| S2NoCD | 44157029 | 117807957835 | 2667.932 | 541828917 | 12.271 | NaN | 0.000 | +| S3NoCD | 34491937 | 99999943602 | 2899.227 | 387401839 | 11.232 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466645458 | 12.54523 | 0.00000 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37197502 | 1.0000000 | 87609315426 | 2355.247 | 0.000 | 2355.247 | 467053611 | 12.55605 | 0.00000 | 12.55605 | 206.40667 | 0.0108217 | 19073.48 | 20089.64 | 334.6763156 | -| S1b | 37190655 | 1.0000000 | 85474784067 | 2298.287 | 0.000 | 2298.287 | 466807667 | 12.55175 | 0.00000 | 12.55175 | 149.44599 | 0.0065202 | 22920.31 | 25093.04 | 176.5661465 | -| S1c | 37195162 | 1.0000000 | 86086185363 | 2314.446 | 0.000 | 2314.446 | 466843147 | 12.55118 | 0.00000 | 12.55118 | 165.60516 | 0.0059532 | 27817.85 | 30805.50 | 132.0547739 | -| S2NoCD | 22074342 | 0.5934433 | 58922537505 | 2669.277 | 1389.169 | 2148.841 | 270895360 | 12.27196 | 12.94411 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S2a | 22077777 | 0.5935356 | 62347138314 | 2823.977 | 1389.169 | 2240.779 | 271063504 | 12.27766 | 12.94411 | 12.54855 | 91.93817 | 0.0033250 | 27650.44 | 27108.82 | 74.3210751 | -| S3NoCD | 17254548 | 0.4638687 | 50064966233 | 2901.552 | 1497.584 | 2148.841 | 193797357 | 11.23167 | 13.68174 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S3a | 17251608 | 0.4637896 | 52066304895 | 3018.055 | 1497.584 | 2202.763 | 193847860 | 11.23651 | 13.68174 | 12.54767 | 53.92205 | 0.0024391 | 22107.45 | 24063.44 | 68.0408589 | -| S3b | 17246874 | 0.4636624 | 53626126689 | 3109.324 | 1497.584 | 2244.887 | 193956939 | 11.24592 | 13.68174 | 12.55234 | 96.04666 | 0.0071128 | 13503.33 | 14580.18 | 259.6024694 | -| S3c | 17246125 | 0.4636422 | 52687996543 | 3055.063 | 1497.584 | 2219.697 | 193867414 | 11.24122 | 13.68174 | 12.55021 | 70.85627 | 0.0049815 | 14223.79 | 16078.26 | 178.2287927 | -| S3d | 17255729 | 0.4639004 | 52823751959 | 3061.230 | 1497.584 | 2222.960 | 193917114 | 11.23784 | 13.68174 | 12.54801 | 74.11923 | 0.0027851 | 26612.42 | 25873.76 | 65.1460215 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 933240063 | 12.54547 | 0.00000 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74386318 | 1.0000000 | 175298229824 | 2356.592 | 0.000 | 2356.592 | 934033198 | 12.55652 | 0.00000 | 12.55652 | 206.72538 | 0.0110449 | 18716.85 | 19145.74 | 345.51881 | +| S1b | 74385413 | 1.0000000 | 170952563916 | 2298.200 | 0.000 | 2298.200 | 933637487 | 12.55135 | 0.00000 | 12.55135 | 148.33311 | 0.0058779 | 25235.73 | 26468.96 | 145.56189 | +| S1c | 74390720 | 1.0000000 | 171904343832 | 2310.830 | 0.000 | 2310.830 | 933570750 | 12.54956 | 0.00000 | 12.54956 | 160.96350 | 0.0040854 | 39399.80 | 42521.81 | 43.30591 | +| S2NoCD | 44157029 | 0.5935995 | 117807957835 | 2667.932 | 1393.167 | 2149.867 | 541828917 | 12.27050 | 12.94711 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44154576 | 0.5935665 | 124844786047 | 2827.448 | 1393.167 | 2244.508 | 542208652 | 12.27978 | 12.94711 | 12.55101 | 94.64148 | 0.0055317 | 17108.96 | 17185.88 | 181.94301 | +| S3NoCD | 34491937 | 0.4636724 | 99999943602 | 2899.227 | 1502.021 | 2149.867 | 387401839 | 11.23166 | 13.68131 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34494037 | 0.4637007 | 104115381916 | 3018.359 | 1502.021 | 2205.148 | 387590904 | 11.23646 | 13.68131 | 12.54763 | 55.28112 | 0.0021554 | 25648.14 | 24833.08 | 52.48718 | +| S3b | 34509196 | 0.4639044 | 107308147373 | 3109.552 | 1502.021 | 2247.762 | 388040453 | 11.24455 | 13.68131 | 12.55088 | 97.89513 | 0.0054106 | 18093.14 | 16319.03 | 172.63598 | +| S3c | 34504471 | 0.4638409 | 105270593424 | 3050.926 | 1502.021 | 2220.467 | 387852045 | 11.24063 | 13.68131 | 12.54922 | 70.59986 | 0.0037469 | 18842.32 | 16916.05 | 116.74399 | +| S3d | 34501231 | 0.4637974 | 105602366018 | 3060.829 | 1502.021 | 2224.992 | 387776869 | 11.23951 | 13.68131 | 12.54881 | 75.12527 | 0.0033322 | 22545.40 | 20600.86 | 91.48361 | ![](../../outputs/Sen2_50_Med_Adherence_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277801 | 0.1541410 | 0.2732173 | 0.0911566 | 0.4030472 | 0.0760263 | 0.1284096 | 0.0111267 | 0.8424613 | 0.0461119 | 0.0491189 | 0.0110335 | 0.0019273 | 0.3999881 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240553 | 0.1447802 | 0.2157515 | 0.0856247 | 0.4086320 | 0.0767122 | 0.1293709 | 0.0112159 | 0.8424572 | 0.0461045 | 0.0491178 | 0.0110465 | 0.0019286 | 0.2945268 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229349 | 0.1422163 | 0.1962587 | 0.0839634 | 0.4092320 | 0.0769957 | 0.1299784 | 0.0112125 | 0.8424873 | 0.0461079 | 0.0491353 | 0.0110154 | 0.0019116 | 0.2602946 | -| S2NoCD | 0.5934433 | 0.5822732 | 0.7055457 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935356 | 0.5822958 | 0.7060348 | 0.0214261 | 0.1433997 | 0.2089133 | 0.0847853 | 0.4076552 | 0.0767471 | 0.1292182 | 0.0111992 | 0.8425444 | 0.0460948 | 0.0491128 | 0.0109898 | 0.0019109 | 0.2776121 | -| S3NoCD | 0.4638687 | 0.4156354 | 0.5870736 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4637896 | 0.4156229 | 0.5868096 | 0.0197697 | 0.1380286 | 0.1714296 | 0.0812364 | 0.4112879 | 0.0772285 | 0.1300383 | 0.0112027 | 0.8426261 | 0.0461014 | 0.0490230 | 0.0109954 | 0.0019093 | 0.2168391 | -| S3b | 0.4636624 | 0.4156278 | 0.5873096 | 0.0217273 | 0.1440757 | 0.2123156 | 0.0853238 | 0.4076544 | 0.0766218 | 0.1293406 | 0.0111731 | 0.8425735 | 0.0461000 | 0.0490636 | 0.0110097 | 0.0019108 | 0.2840923 | -| S3c | 0.4636422 | 0.4155696 | 0.5876213 | 0.0206711 | 0.1409315 | 0.1917630 | 0.0832429 | 0.4099172 | 0.0770213 | 0.1297097 | 0.0111987 | 0.8425381 | 0.0460824 | 0.0491061 | 0.0110204 | 0.0019145 | 0.2493205 | -| S3d | 0.4639004 | 0.4157123 | 0.5874098 | 0.0202417 | 0.1395900 | 0.1822885 | 0.0822922 | 0.4104446 | 0.0770251 | 0.1298089 | 0.0112098 | 0.8425700 | 0.0461324 | 0.0490486 | 0.0110024 | 0.0019036 | 0.2342313 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277770 | 0.1541676 | 0.2735725 | 0.0911068 | 0.4036872 | 0.0760433 | 0.1284919 | 0.0111234 | 0.8424045 | 0.0461250 | 0.0491350 | 0.0110626 | 0.0019277 | 0.4003768 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240246 | 0.1449184 | 0.2159908 | 0.0856256 | 0.4082615 | 0.0767149 | 0.1294255 | 0.0111919 | 0.8424441 | 0.0461406 | 0.0491198 | 0.0110327 | 0.0019206 | 0.2943838 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229387 | 0.1419011 | 0.1959119 | 0.0838224 | 0.4094144 | 0.0768280 | 0.1296761 | 0.0111991 | 0.8425663 | 0.0460770 | 0.0490825 | 0.0110176 | 0.0019137 | 0.2600889 | +| S2NoCD | 0.5935995 | 0.5823361 | 0.7054688 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5935665 | 0.5824146 | 0.7059463 | 0.0213966 | 0.1438505 | 0.2094804 | 0.0850851 | 0.4086675 | 0.0767385 | 0.1294165 | 0.0112173 | 0.8425126 | 0.0461064 | 0.0490974 | 0.0110198 | 0.0019173 | 0.2779271 | +| S3NoCD | 0.4636724 | 0.4154340 | 0.5860893 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4637007 | 0.4155277 | 0.5865311 | 0.0197899 | 0.1383033 | 0.1717111 | 0.0814794 | 0.4121234 | 0.0772548 | 0.1301283 | 0.0112118 | 0.8425199 | 0.0460735 | 0.0491517 | 0.0110056 | 0.0019051 | 0.2173159 | +| S3b | 0.4639044 | 0.4157857 | 0.5876752 | 0.0217416 | 0.1441790 | 0.2124183 | 0.0853294 | 0.4094186 | 0.0768062 | 0.1294332 | 0.0111818 | 0.8424143 | 0.0460965 | 0.0491883 | 0.0110409 | 0.0019176 | 0.2844185 | +| S3c | 0.4638409 | 0.4156951 | 0.5869250 | 0.0206754 | 0.1410634 | 0.1917068 | 0.0833411 | 0.4105793 | 0.0769845 | 0.1297108 | 0.0112077 | 0.8424894 | 0.0460833 | 0.0491418 | 0.0110239 | 0.0019170 | 0.2496308 | +| S3d | 0.4637974 | 0.4156677 | 0.5868810 | 0.0202585 | 0.1397122 | 0.1824904 | 0.0824625 | 0.4112144 | 0.0771280 | 0.1298555 | 0.0112228 | 0.8424917 | 0.0460937 | 0.0491366 | 0.0110229 | 0.0019114 | 0.2345851 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 14.44677 hours + ## Time difference of 1.269854 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence3yrs.md index b9a0b75..4bbf467 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 30% Medication Adherence ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466614758 | 12.545 | 625082.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466676159 | 12.546 | 625142.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466645458 | 12.545 | 625112.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195779 | 626218800 | 71281372 | 186100281 | 33119195 | 13388772 | 0.026 | 0.159 | 0.310 | 0.094 | 14905588 | 2814123 | 4756454 | 412031 | 0.209 | 0.039 | 0.067 | 0.006 | 527524487 | 28873365 | 30786968 | 6925999 | 1208772 | 90753454326 | 2439.886 | 467242138 | 12.562 | 625645.0 | 292.777 | 0.017 | 17116.09 | 562.492 | -| S1b | 37200476 | 626144172 | 71252445 | 188422793 | 23802097 | 13372758 | 0.022 | 0.148 | 0.240 | 0.088 | 15103031 | 2841048 | 4796549 | 415612 | 0.212 | 0.040 | 0.067 | 0.006 | 527481440 | 28877807 | 30767692 | 6915814 | 1204950 | 87878153022 | 2362.286 | 466988044 | 12.553 | 625301.8 | 215.177 | 0.009 | 24764.46 | 219.270 | -| S1c | 37192813 | 625960445 | 71159107 | 189176712 | 20537777 | 13372239 | 0.020 | 0.144 | 0.214 | 0.085 | 15172732 | 2850944 | 4816068 | 416845 | 0.213 | 0.040 | 0.068 | 0.006 | 527395566 | 28830750 | 30734973 | 6903078 | 1206962 | 88797560537 | 2387.492 | 466783360 | 12.550 | 625130.7 | 240.384 | 0.006 | 41646.33 | 48.218 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 933216569 | 12.545 | 625108.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 933263557 | 12.546 | 625139.1 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 933240063 | 12.545 | 625123.8 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74380275 | 1252107231 | 142568770 | 372100831 | 66270673 | 26745802 | 0.026 | 0.159 | 0.310 | 0.094 | 29815042 | 5625494 | 9500837 | 824680.0 | 0.209 | 0.039 | 0.067 | 0.006 | 1054730269 | 57758498 | 61574433 | 13835312 | 2423951 | 181401075128 | 2438.833 | 934239602 | 12.560 | 625576.9 | 290.796 | 0.015 | 19152.73 | 468.354 | +| S1b | 74383024 | 1252030978 | 142410670 | 376764647 | 47607118 | 26748888 | 0.022 | 0.148 | 0.241 | 0.088 | 30192660 | 5683507 | 9596337 | 830158.0 | 0.212 | 0.040 | 0.067 | 0.006 | 1054810413 | 57710159 | 61499603 | 13827904 | 2405886 | 175747140584 | 2362.732 | 933787724 | 12.554 | 625326.0 | 214.694 | 0.009 | 24838.03 | 217.495 | +| S1c | 74393892 | 1252166867 | 142379318 | 378416895 | 41063274 | 26758496 | 0.020 | 0.144 | 0.214 | 0.085 | 30350312 | 5702044 | 9621386 | 828456.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054965444 | 57726777 | 61483651 | 13803995 | 2400849 | 177409072797 | 2384.726 | 933746980 | 12.551 | 625184.9 | 236.689 | 0.006 | 37796.71 | 76.419 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ----: | -------------: | -| S2NoCD | 22078563 | 364522749 | 50166624 | 110968095 | 9653606 | 7738507 | 0.017 | 0.141 | 0.159 | 0.087 | 11438971 | 2125413 | 3543389 | 304919 | 0.228 | 0.042 | 0.071 | 0.006 | 298790021 | 18633807 | 22502661 | 5543543 | 1025792 | 58731887921 | 2660.132 | 270917818 | 12.271 | 610871.2 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077788 | 364622606 | 50226923 | 108797477 | 18511084 | 7734136 | 0.023 | 0.157 | 0.269 | 0.097 | 11192847 | 2087413 | 3500787 | 300763 | 0.223 | 0.042 | 0.070 | 0.006 | 298828425 | 18622586 | 22524521 | 5579724 | 1036307 | 63840415723 | 2891.613 | 271190365 | 12.283 | 611278.5 | 231.481 | 0.013 | 18119 | 407.299 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ------: | -------------: | +| S2NoCD | 44156404 | 729084497 | 100330760 | 221928932 | 19330952 | 15481473 | 0.017 | 0.142 | 0.159 | 0.087 | 22917076 | 4253860 | 7098458 | 609501 | 0.228 | 0.042 | 0.071 | 0.006 | 597619551 | 37246010 | 44990133 | 11123560 | 2050468 | 117605933755 | 2663.395 | 541859031 | 12.271 | 610904.5 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44164773 | 729329891 | 100492049 | 217625447 | 37010683 | 15485858 | 0.023 | 0.157 | 0.269 | 0.097 | 22383331 | 4181008 | 7006346 | 603148 | 0.223 | 0.042 | 0.070 | 0.006 | 597700094 | 37284225 | 45068617 | 11147317 | 2064302 | 127735308298 | 2892.244 | 542449119 | 12.282 | 611227.4 | 228.849 | 0.011 | 20737.2 | 322.935 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17243525 | 260017880 | 41691838 | 80059027 | 7819384 | 5815322 | 0.018 | 0.137 | 0.154 | 0.086 | 9754415 | 1816466 | 3038101 | 261338 | 0.234 | 0.044 | 0.073 | 0.006 | 207433146 | 15294590 | 18682841 | 4808648 | 895345 | 49933527334 | 2895.784 | 193676014 | 11.232 | 558694.8 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17245589 | 260114351 | 41778508 | 79305268 | 11012874 | 5816924 | 0.021 | 0.144 | 0.204 | 0.091 | 9648241 | 1803612 | 3027939 | 260144 | 0.231 | 0.043 | 0.072 | 0.006 | 207442211 | 15303706 | 18733677 | 4824249 | 900624 | 53097071421 | 3078.878 | 193814317 | 11.238 | 558845.4 | 183.094 | 0.007 | 27428.51 | 150.672 | -| S3b | 17248093 | 260143539 | 41765340 | 77789956 | 17179218 | 5809490 | 0.027 | 0.156 | 0.293 | 0.099 | 9481831 | 1779958 | 2992091 | 258625 | 0.227 | 0.043 | 0.072 | 0.006 | 207483725 | 15287322 | 18724587 | 4837601 | 899769 | 55163743515 | 3198.252 | 193983110 | 11.247 | 559133.8 | 302.468 | 0.015 | 20395.72 | 439.030 | -| S3c | 17249568 | 260123652 | 41796963 | 78552778 | 14093542 | 5811921 | 0.024 | 0.150 | 0.249 | 0.095 | 9556493 | 1794042 | 3007246 | 258985 | 0.229 | 0.043 | 0.072 | 0.006 | 207434647 | 15324709 | 18727689 | 4823824 | 902793 | 53820717606 | 3120.120 | 193896397 | 11.241 | 558912.5 | 224.336 | 0.009 | 25373.54 | 217.730 | -| S3d | 17250373 | 260166499 | 41788451 | 78909896 | 12694599 | 5812281 | 0.023 | 0.147 | 0.229 | 0.093 | 9596955 | 1798651 | 3013620 | 260246 | 0.230 | 0.043 | 0.072 | 0.006 | 207483596 | 15310784 | 18731510 | 4829309 | 900292 | 54140141633 | 3138.491 | 193895422 | 11.240 | 558865.1 | 242.707 | 0.008 | 29382.46 | 170.306 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34500334 | 520264617 | 83469550 | 160191877 | 15617539 | 11630123 | 0.018 | 0.137 | 0.154 | 0.086 | 19525292 | 3631989 | 6073558 | 522424 | 0.234 | 0.044 | 0.073 | 0.006 | 415002016 | 30608834 | 37422882 | 9624470 | 1788687 | 99842281258 | 2893.951 | 387517176 | 11.232 | 558719.7 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34507415 | 520428951 | 83482576 | 158676520 | 22030098 | 11639538 | 0.021 | 0.144 | 0.204 | 0.091 | 19287934 | 3609226 | 6045313 | 521405 | 0.231 | 0.043 | 0.072 | 0.006 | 415152628 | 30610103 | 37407716 | 9641236 | 1794702 | 106095806862 | 3074.580 | 387796823 | 11.238 | 558829.0 | 180.629 | 0.006 | 31147.82 | 109.325 | +| S3b | 34499539 | 520396932 | 83618002 | 155590263 | 34428826 | 11625591 | 0.027 | 0.156 | 0.293 | 0.099 | 18988453 | 3564625 | 5980823 | 516662 | 0.227 | 0.043 | 0.072 | 0.006 | 414988556 | 30607762 | 37472866 | 9688489 | 1813970 | 110363699543 | 3198.991 | 388038736 | 11.248 | 559183.5 | 305.039 | 0.015 | 19837.73 | 463.797 | +| S3c | 34496334 | 520227370 | 83568351 | 157099275 | 28171361 | 11622564 | 0.024 | 0.150 | 0.249 | 0.095 | 19145218 | 3585036 | 6010150 | 518449 | 0.229 | 0.043 | 0.072 | 0.006 | 414875686 | 30589301 | 37479876 | 9661353 | 1804425 | 107627143927 | 3119.959 | 387776879 | 11.241 | 558935.2 | 226.008 | 0.009 | 25592.92 | 215.536 | +| S3d | 34507664 | 520495018 | 83555471 | 157877292 | 25364366 | 11630839 | 0.023 | 0.147 | 0.229 | 0.093 | 19209915 | 3595849 | 6028084 | 520340 | 0.230 | 0.043 | 0.072 | 0.006 | 415141325 | 30594930 | 37472224 | 9653084 | 1805226 | 108255487965 | 3137.143 | 387911628 | 11.241 | 558928.8 | 243.192 | 0.009 | 26887.15 | 209.054 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S1a | 37195779 | 90753454326 | 2439.886 | 467242138 | 12.562 | 17116.09 | 562.492 | -| S3b | 17248093 | 55163743515 | 3198.252 | 193983110 | 11.247 | 20395.72 | 439.030 | -| S2a | 22077788 | 63840415723 | 2891.613 | 271190365 | 12.283 | 18119.00 | 407.299 | -| S1b | 37200476 | 87878153022 | 2362.286 | 466988044 | 12.553 | 24764.46 | 219.270 | -| S3c | 17249568 | 53820717606 | 3120.120 | 193896397 | 11.241 | 25373.54 | 217.730 | -| S3d | 17250373 | 54140141633 | 3138.491 | 193895422 | 11.240 | 29382.46 | 170.306 | -| S3a | 17245589 | 53097071421 | 3078.878 | 193814317 | 11.238 | 27428.51 | 150.672 | -| S1c | 37192813 | 88797560537 | 2387.492 | 466783360 | 12.550 | 41646.33 | 48.218 | -| S1NoCD | 37196486 | 79864892645 | 2147.109 | 466614758 | 12.545 | NaN | 0.000 | -| S2NoCD | 22078563 | 58731887921 | 2660.132 | 270917818 | 12.271 | NaN | 0.000 | -| S3NoCD | 17243525 | 49933527334 | 2895.784 | 193676014 | 11.232 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S1a | 74380275 | 181401075128 | 2438.833 | 934239602 | 12.560 | 19152.73 | 468.354 | +| S3b | 34499539 | 110363699543 | 3198.991 | 388038736 | 11.248 | 19837.73 | 463.797 | +| S2a | 44164773 | 127735308298 | 2892.244 | 542449119 | 12.282 | 20737.20 | 322.935 | +| S1b | 74383024 | 175747140584 | 2362.732 | 933787724 | 12.554 | 24838.03 | 217.495 | +| S3c | 34496334 | 107627143927 | 3119.959 | 387776879 | 11.241 | 25592.92 | 215.536 | +| S3d | 34507664 | 108255487965 | 3137.143 | 387911628 | 11.241 | 26887.15 | 209.054 | +| S3a | 34507415 | 106095806862 | 3074.580 | 387796823 | 11.238 | 31147.82 | 109.325 | +| S1c | 74393892 | 177409072797 | 2384.726 | 933746980 | 12.551 | 37796.71 | 76.419 | +| S1NoCD | 74388747 | 159789813678 | 2148.037 | 933216569 | 12.545 | NaN | 0.000 | +| S2NoCD | 44156404 | 117605933755 | 2663.395 | 541859031 | 12.271 | NaN | 0.000 | +| S3NoCD | 34500334 | 99842281258 | 2893.951 | 387517176 | 11.232 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466645458 | 12.54523 | 0.00000 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37195779 | 1.0000000 | 90753454326 | 2439.886 | 0.000 | 2439.886 | 467242138 | 12.56170 | 0.00000 | 12.56170 | 291.04522 | 0.0164718 | 17669.33 | 17116.09 | 532.5435790 | -| S1b | 37200476 | 1.0000000 | 87878153022 | 2362.286 | 0.000 | 2362.286 | 466988044 | 12.55328 | 0.00000 | 12.55328 | 213.44510 | 0.0080553 | 26497.34 | 24764.46 | 189.3218597 | -| S1c | 37192813 | 1.0000000 | 88797560537 | 2387.492 | 0.000 | 2387.492 | 466783360 | 12.55036 | 0.00000 | 12.55036 | 238.65184 | 0.0051384 | 46444.60 | 41646.33 | 18.2691463 | -| S2NoCD | 22078563 | 0.5935568 | 58731887921 | 2660.132 | 1402.167 | 2148.841 | 270917818 | 12.27063 | 12.94624 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S2a | 22077788 | 0.5935359 | 63840415723 | 2891.613 | 1402.167 | 2286.207 | 271190365 | 12.28340 | 12.94624 | 12.55282 | 137.36611 | 0.0075969 | 18081.98 | 18119.00 | 242.4848714 | -| S3NoCD | 17243525 | 0.4635723 | 49933527334 | 2895.784 | 1503.344 | 2148.841 | 193676014 | 11.23181 | 13.68026 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S3a | 17245589 | 0.4636278 | 53097071421 | 3078.878 | 1503.344 | 2233.805 | 193814317 | 11.23849 | 13.68026 | 12.54819 | 84.96483 | 0.0029590 | 28713.97 | 27428.51 | 62.9938915 | -| S3b | 17248093 | 0.4636951 | 55163743515 | 3198.252 | 1503.344 | 2289.264 | 193983110 | 11.24664 | 13.68026 | 12.55180 | 140.42373 | 0.0065759 | 21354.32 | 20395.72 | 188.3794023 | -| S3c | 17249568 | 0.4637348 | 53820717606 | 3120.120 | 1503.344 | 2253.099 | 193896397 | 11.24065 | 13.68026 | 12.54893 | 104.25841 | 0.0037023 | 28160.79 | 25373.54 | 80.8627246 | -| S3d | 17250373 | 0.4637564 | 54140141633 | 3138.491 | 1503.344 | 2261.654 | 193895422 | 11.24007 | 13.68026 | 12.54861 | 112.81322 | 0.0033800 | 33376.80 | 29382.46 | 56.1946409 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 933240063 | 12.54547 | 0.00000 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74380275 | 1.0000000 | 181401075128 | 2438.833 | 0.000 | 2438.833 | 934239602 | 12.56031 | 0.00000 | 12.56031 | 288.96609 | 0.0148400 | 19472.10 | 19152.73 | 453.03421 | +| S1b | 74383024 | 1.0000000 | 175747140584 | 2362.732 | 0.000 | 2362.732 | 933787724 | 12.55377 | 0.00000 | 12.55377 | 212.86487 | 0.0083008 | 25643.89 | 24838.02 | 202.17518 | +| S1c | 74393892 | 1.0000000 | 177409072797 | 2384.726 | 0.000 | 2384.726 | 933746980 | 12.55139 | 0.00000 | 12.55139 | 234.85933 | 0.0059192 | 39677.70 | 37796.70 | 61.09955 | +| S2NoCD | 44156404 | 0.5935911 | 117605933755 | 2663.395 | 1399.821 | 2149.867 | 541859031 | 12.27136 | 12.94584 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44164773 | 0.5937036 | 127735308298 | 2892.244 | 1399.821 | 2285.878 | 542449119 | 12.28239 | 12.94584 | 12.55195 | 136.01091 | 0.0064761 | 21002.14 | 20737.20 | 187.79161 | +| S3NoCD | 34500334 | 0.4637853 | 99842281258 | 2893.951 | 1506.290 | 2149.867 | 387517176 | 11.23227 | 13.68129 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34507415 | 0.4638805 | 106095806862 | 3074.580 | 1506.290 | 2233.789 | 387796823 | 11.23807 | 13.68129 | 12.54793 | 83.92228 | 0.0024570 | 34156.94 | 31147.82 | 38.92579 | +| S3b | 34499539 | 0.4637746 | 110363699543 | 3198.991 | 1506.290 | 2291.322 | 388038736 | 11.24765 | 13.68129 | 12.55263 | 141.45471 | 0.0071575 | 19763.12 | 19837.73 | 216.42072 | +| S3c | 34496334 | 0.4637315 | 107627143927 | 3119.959 | 1506.290 | 2254.599 | 387776879 | 11.24110 | 13.68129 | 12.54970 | 104.73230 | 0.0042268 | 24777.92 | 25592.93 | 106.60970 | +| S3d | 34507664 | 0.4638839 | 108255487965 | 3137.143 | 1506.290 | 2262.817 | 387911628 | 11.24132 | 13.68129 | 12.54943 | 112.94966 | 0.0039545 | 28562.49 | 26887.15 | 84.77408 | ![](../../outputs/Sen3_30_Med_Adherence_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264130 | 0.1594355 | 0.3100498 | 0.0943012 | 0.4007333 | 0.0756571 | 0.1278762 | 0.0110774 | 0.8423964 | 0.0461075 | 0.0491633 | 0.0110600 | 0.0019303 | 0.4646262 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216055 | 0.1480604 | 0.2404960 | 0.0875941 | 0.4059903 | 0.0763713 | 0.1289378 | 0.0111722 | 0.8424281 | 0.0461201 | 0.0491384 | 0.0110451 | 0.0019244 | 0.3340531 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201493 | 0.1442413 | 0.2143855 | 0.0852093 | 0.4079480 | 0.0766531 | 0.1294892 | 0.0112077 | 0.8425382 | 0.0460584 | 0.0491005 | 0.0110280 | 0.0019282 | 0.2886177 | -| S2NoCD | 0.5935568 | 0.5823097 | 0.7053578 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935359 | 0.5824692 | 0.7062056 | 0.0223351 | 0.1468614 | 0.2290467 | 0.0868672 | 0.4071715 | 0.0764348 | 0.1292457 | 0.0111517 | 0.8425215 | 0.0460676 | 0.0490957 | 0.0110473 | 0.0019254 | 0.3104013 | -| S3NoCD | 0.4635723 | 0.4153676 | 0.5861997 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4636278 | 0.4155217 | 0.5874183 | 0.0201358 | 0.1392626 | 0.1805149 | 0.0822287 | 0.4109128 | 0.0771069 | 0.1301110 | 0.0112307 | 0.8424794 | 0.0461006 | 0.0491419 | 0.0110143 | 0.0019170 | 0.2306846 | -| S3b | 0.4636951 | 0.4155683 | 0.5872332 | 0.0226883 | 0.1466743 | 0.2326983 | 0.0870001 | 0.4064201 | 0.0764674 | 0.1291411 | 0.0111894 | 0.8425049 | 0.0460727 | 0.0491259 | 0.0110354 | 0.0019156 | 0.3174192 | -| S3c | 0.4637348 | 0.4155365 | 0.5876778 | 0.0213351 | 0.1429510 | 0.2072023 | 0.0845726 | 0.4084161 | 0.0768439 | 0.1295450 | 0.0111987 | 0.8424543 | 0.0461336 | 0.0491319 | 0.0110136 | 0.0019205 | 0.2739520 | -| S3d | 0.4637564 | 0.4156050 | 0.5875581 | 0.0207664 | 0.1413812 | 0.1952106 | 0.0835996 | 0.4094977 | 0.0769666 | 0.1297144 | 0.0112325 | 0.8424726 | 0.0461088 | 0.0491357 | 0.0110219 | 0.0019164 | 0.2543044 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264033 | 0.1593018 | 0.3099946 | 0.0940914 | 0.4008461 | 0.0756315 | 0.1277333 | 0.0110873 | 0.8423642 | 0.0461290 | 0.0491766 | 0.0110496 | 0.0019359 | 0.4648330 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216398 | 0.1482342 | 0.2406521 | 0.0877947 | 0.4059079 | 0.0764087 | 0.1290125 | 0.0111606 | 0.8424795 | 0.0460932 | 0.0491199 | 0.0110444 | 0.0019216 | 0.3342946 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201517 | 0.1441110 | 0.2141912 | 0.0851720 | 0.4079678 | 0.0766467 | 0.1293303 | 0.0111361 | 0.8425119 | 0.0461015 | 0.0491018 | 0.0110241 | 0.0019174 | 0.2884076 | +| S2NoCD | 0.5935911 | 0.5823656 | 0.7051165 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5937036 | 0.5825616 | 0.7062500 | 0.0223572 | 0.1465203 | 0.2287835 | 0.0867962 | 0.4069072 | 0.0764858 | 0.1291620 | 0.0111850 | 0.8424534 | 0.0460995 | 0.0491621 | 0.0110233 | 0.0019191 | 0.3102030 | +| S3NoCD | 0.4637853 | 0.4155681 | 0.5866172 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4638805 | 0.4156993 | 0.5867088 | 0.0201156 | 0.1395918 | 0.1808230 | 0.0824771 | 0.4108939 | 0.0771596 | 0.1300215 | 0.0112568 | 0.8425660 | 0.0460728 | 0.0490892 | 0.0110179 | 0.0019129 | 0.2311946 | +| S3b | 0.4637746 | 0.4156737 | 0.5876605 | 0.0227032 | 0.1471017 | 0.2332507 | 0.0873282 | 0.4068980 | 0.0765657 | 0.1291642 | 0.0111939 | 0.8424573 | 0.0460719 | 0.0491421 | 0.0110558 | 0.0019283 | 0.3181560 | +| S3c | 0.4637315 | 0.4155383 | 0.5873116 | 0.0213262 | 0.1432680 | 0.2074859 | 0.0848645 | 0.4090175 | 0.0768424 | 0.1295624 | 0.0112182 | 0.8424856 | 0.0460621 | 0.0491521 | 0.0110349 | 0.0019208 | 0.2742435 | +| S3d | 0.4638839 | 0.4157521 | 0.5872211 | 0.0207546 | 0.1415673 | 0.1954816 | 0.0837051 | 0.4098442 | 0.0769796 | 0.1297896 | 0.0112424 | 0.8425108 | 0.0460587 | 0.0491390 | 0.0110271 | 0.0019212 | 0.2545329 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 14.46069 hours + ## Time difference of 1.210629 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence5yrs.md index 3755008..fc870e5 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen3_30_Med_Adherence5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 30% Medication Adherence ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD2 | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466614758 | 12.545 | 625082.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466676159 | 12.546 | 625142.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466645458 | 12.545 | 625112.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37197502 | 626089853 | 71222084 | 122776626 | 28487983 | 16327137 | 0.028 | 0.154 | 0.273 | 0.091 | 14992350 | 2827989 | 4776515 | 413886 | 0.211 | 0.040 | 0.067 | 0.006 | 527456443 | 28870190 | 30752817 | 6907934 | 1206659 | 87609315426 | 2355.247 | 467053611 | 12.556 | 625447.1 | 204.675 | 0.010 | 20089.64 | 304.729 | -| S1b | 37190655 | 625992698 | 71214502 | 123717512 | 20974578 | 16327973 | 0.024 | 0.145 | 0.216 | 0.086 | 15197291 | 2852978 | 4811387 | 417126 | 0.213 | 0.040 | 0.068 | 0.006 | 527372066 | 28861102 | 30747408 | 6915037 | 1207305 | 85474784067 | 2298.287 | 466807667 | 12.552 | 625289.0 | 147.714 | 0.006 | 25093.04 | 146.619 | -| S1c | 37195162 | 626110982 | 71210037 | 124047387 | 18535585 | 16324587 | 0.023 | 0.142 | 0.196 | 0.084 | 15221449 | 2863867 | 4834566 | 417049 | 0.214 | 0.040 | 0.068 | 0.006 | 527490541 | 28868640 | 30764128 | 6896850 | 1196858 | 86086185363 | 2314.446 | 466843147 | 12.551 | 625244.5 | 163.873 | 0.005 | 30805.50 | 102.107 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD2 | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 933216569 | 12.545 | 625108.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 933263557 | 12.546 | 625139.1 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 933240063 | 12.545 | 625123.8 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386318 | 1252092577 | 142511621 | 245523949 | 57058349 | 32655914 | 0.028 | 0.154 | 0.274 | 0.091 | 30028808 | 5656584 | 9558038 | 827432.0 | 0.211 | 0.040 | 0.067 | 0.006 | 1054768469 | 57752767 | 61521629 | 13851433 | 2413714 | 175298229824 | 2356.592 | 934033198 | 12.557 | 625469.3 | 204.896 | 0.011 | 19145.74 | 330.199 | +| S1b | 74385413 | 1252007176 | 142455061 | 247448362 | 41936466 | 32651747 | 0.024 | 0.145 | 0.216 | 0.086 | 30368698 | 5706469 | 9627370 | 832514.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054746061 | 57768304 | 61498391 | 13812986 | 2404656 | 170952563916 | 2298.200 | 933637487 | 12.551 | 625269.4 | 146.504 | 0.006 | 26468.96 | 130.242 | +| S1c | 74390720 | 1252048091 | 142295860 | 248074520 | 37009576 | 32668233 | 0.023 | 0.142 | 0.196 | 0.084 | 30456632 | 5715293 | 9646702 | 833108.0 | 0.214 | 0.040 | 0.068 | 0.006 | 1054933501 | 57690667 | 61453687 | 13794504 | 2396041 | 171904343832 | 2310.830 | 933570750 | 12.550 | 625167.1 | 159.134 | 0.004 | 42521.81 | 27.986 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22074342 | 364499893 | 50179989 | 72492409 | 9769650 | 9434235 | 0.021 | 0.142 | 0.160 | 0.087 | 11472370 | 2126666 | 3551252 | 304704 | 0.229 | 0.042 | 0.071 | 0.006 | 298757005 | 18626945 | 22501053 | 5562438 | 1027303 | 58922537505 | 2669.277 | 270895360 | 12.272 | 610928.5 | 0.0 | 0.000 | NaN | 0.000 | -| S2a | 22077777 | 364514086 | 50214779 | 71673455 | 16290550 | 9435494 | 0.025 | 0.153 | 0.241 | 0.095 | 11245330 | 2100490 | 3507989 | 302346 | 0.224 | 0.042 | 0.070 | 0.006 | 298734836 | 18629376 | 22530917 | 5562183 | 1028646 | 62347138314 | 2823.977 | 271063504 | 12.278 | 611059.2 | 154.7 | 0.006 | 27108.82 | 130.631 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44157029 | 729047563 | 100380900 | 145000421 | 19524492 | 18863743 | 0.021 | 0.142 | 0.160 | 0.087 | 22925265 | 4254784 | 7099566 | 609563 | 0.228 | 0.042 | 0.071 | 0.006 | 597538799 | 37245010 | 45040554 | 11117169 | 2054803 | 117807957835 | 2667.932 | 541828917 | 12.271 | 610857.2 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44154576 | 729145856 | 100448839 | 143361789 | 32595478 | 18878233 | 0.025 | 0.154 | 0.242 | 0.095 | 22519648 | 4200194 | 7025459 | 605531 | 0.224 | 0.042 | 0.070 | 0.006 | 597564735 | 37286040 | 45033303 | 11135908 | 2066352 | 124844786047 | 2827.448 | 542208652 | 12.280 | 611161.7 | 159.516 | 0.009 | 17185.88 | 304.575 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17254548 | 260185517 | 41753987 | 52456874 | 7922835 | 7061036 | 0.022 | 0.137 | 0.155 | 0.086 | 9767617 | 1818208 | 3040076 | 262205 | 0.234 | 0.044 | 0.073 | 0.006 | 207533583 | 15301679 | 18724752 | 4815426 | 897482 | 50064966233 | 2901.552 | 193797357 | 11.232 | 558681.9 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17251608 | 260177738 | 41735217 | 52193377 | 10112286 | 7056308 | 0.024 | 0.142 | 0.189 | 0.089 | 9673981 | 1809610 | 3026757 | 259927 | 0.232 | 0.043 | 0.073 | 0.006 | 207543323 | 15307443 | 18697708 | 4818609 | 897810 | 52066304895 | 3018.055 | 193847860 | 11.237 | 558807.4 | 116.503 | 0.005 | 24063.44 | 125.572 | -| S3b | 17246874 | 260180750 | 41770771 | 51592135 | 14901907 | 7060341 | 0.029 | 0.152 | 0.258 | 0.096 | 9537491 | 1786791 | 3000373 | 258790 | 0.228 | 0.043 | 0.072 | 0.006 | 207513062 | 15306657 | 18723252 | 4827550 | 898750 | 53626126689 | 3109.324 | 193956939 | 11.246 | 559186.6 | 207.773 | 0.014 | 14580.17 | 504.745 | -| S3c | 17246125 | 260144350 | 41792942 | 51894923 | 12432863 | 7060467 | 0.026 | 0.147 | 0.223 | 0.093 | 9621451 | 1801612 | 3014035 | 259735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459068 | 15294280 | 18748666 | 4834049 | 901039 | 52687996543 | 3055.063 | 193867414 | 11.241 | 559005.7 | 153.511 | 0.010 | 16078.26 | 323.876 | -| S3d | 17255729 | 260233694 | 41777900 | 52047317 | 11356970 | 7062160 | 0.025 | 0.144 | 0.207 | 0.091 | 9643777 | 1802264 | 3018596 | 260225 | 0.231 | 0.043 | 0.072 | 0.006 | 207557193 | 15328896 | 18715546 | 4823282 | 894293 | 52823751959 | 3061.230 | 193917114 | 11.238 | 558830.7 | 159.678 | 0.006 | 25873.76 | 148.893 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34491937 | 520096794 | 83394436 | 104866546 | 15798844 | 14116443 | 0.022 | 0.137 | 0.154 | 0.086 | 19479590 | 3630576 | 6075819 | 523166 | 0.234 | 0.044 | 0.073 | 0.006 | 414917152 | 30599570 | 37365292 | 9614469 | 1790750 | 99999943602 | 2899.227 | 387401839 | 11.232 | 558684.0 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34494037 | 520214111 | 83457293 | 104351592 | 20245608 | 14129448 | 0.024 | 0.142 | 0.189 | 0.089 | 19332282 | 3614629 | 6055063 | 518761 | 0.232 | 0.043 | 0.073 | 0.006 | 414968911 | 30599997 | 37426814 | 9615582 | 1787056 | 104115381916 | 3018.359 | 387590904 | 11.236 | 558804.7 | 119.132 | 0.005 | 24833.08 | 120.734 | +| S3b | 34509196 | 520537138 | 83620081 | 103218767 | 29823148 | 14132996 | 0.029 | 0.152 | 0.258 | 0.096 | 19135380 | 3582069 | 6004729 | 516649 | 0.229 | 0.043 | 0.072 | 0.006 | 415119150 | 30640730 | 37483240 | 9661621 | 1802895 | 107308147373 | 3109.552 | 388040453 | 11.245 | 559118.1 | 210.326 | 0.013 | 16319.03 | 434.092 | +| S3c | 34504471 | 520423616 | 83513343 | 103824096 | 24853847 | 14121585 | 0.026 | 0.146 | 0.223 | 0.093 | 19220385 | 3595075 | 6024956 | 518536 | 0.230 | 0.043 | 0.072 | 0.006 | 415113845 | 30619979 | 37421385 | 9639642 | 1802009 | 105270593424 | 3050.926 | 387852045 | 11.241 | 558980.7 | 151.699 | 0.009 | 16916.05 | 296.690 | +| S3d | 34501231 | 520389346 | 83507084 | 104079260 | 22711874 | 14135933 | 0.025 | 0.144 | 0.207 | 0.091 | 19266710 | 3605577 | 6035420 | 519637 | 0.231 | 0.043 | 0.072 | 0.006 | 415086795 | 30631737 | 37413709 | 9638221 | 1794998 | 105602366018 | 3060.829 | 387776869 | 11.240 | 558914.6 | 161.602 | 0.008 | 20600.86 | 230.620 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S3b | 17246874 | 53626126689 | 3109.324 | 193956939 | 11.246 | 14580.17 | 504.745 | -| S3c | 17246125 | 52687996543 | 3055.063 | 193867414 | 11.241 | 16078.26 | 323.876 | -| S1a | 37197502 | 87609315426 | 2355.247 | 467053611 | 12.556 | 20089.64 | 304.729 | -| S3d | 17255729 | 52823751959 | 3061.230 | 193917114 | 11.238 | 25873.76 | 148.893 | -| S1b | 37190655 | 85474784067 | 2298.287 | 466807667 | 12.552 | 25093.04 | 146.619 | -| S2a | 22077777 | 62347138314 | 2823.977 | 271063504 | 12.278 | 27108.82 | 130.631 | -| S3a | 17251608 | 52066304895 | 3018.055 | 193847860 | 11.237 | 24063.44 | 125.572 | -| S1c | 37195162 | 86086185363 | 2314.446 | 466843147 | 12.551 | 30805.50 | 102.107 | -| S1NoCD | 37197623 | 79996190237 | 2150.573 | 466676159 | 12.546 | NaN | 0.000 | -| S2NoCD | 22074342 | 58922537505 | 2669.277 | 270895360 | 12.272 | NaN | 0.000 | -| S3NoCD | 17254548 | 50064966233 | 2901.552 | 193797357 | 11.232 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S3b | 34509196 | 107308147373 | 3109.552 | 388040453 | 11.245 | 16319.03 | 434.092 | +| S1a | 74386318 | 175298229824 | 2356.592 | 934033198 | 12.557 | 19145.74 | 330.199 | +| S2a | 44154576 | 124844786047 | 2827.448 | 542208652 | 12.280 | 17185.88 | 304.575 | +| S3c | 34504471 | 105270593424 | 3050.926 | 387852045 | 11.241 | 16916.05 | 296.690 | +| S3d | 34501231 | 105602366018 | 3060.829 | 387776869 | 11.240 | 20600.86 | 230.620 | +| S1b | 74385413 | 170952563916 | 2298.200 | 933637487 | 12.551 | 26468.96 | 130.242 | +| S3a | 34494037 | 104115381916 | 3018.359 | 387590904 | 11.236 | 24833.08 | 120.734 | +| S1c | 74390720 | 171904343832 | 2310.830 | 933570750 | 12.550 | 42521.81 | 27.986 | +| S1NoCD | 74388425 | 160061317736 | 2151.697 | 933263557 | 12.546 | NaN | 0.000 | +| S2NoCD | 44157029 | 117807957835 | 2667.932 | 541828917 | 12.271 | NaN | 0.000 | +| S3NoCD | 34491937 | 99999943602 | 2899.227 | 387401839 | 11.232 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466645458 | 12.54523 | 0.00000 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37197502 | 1.0000000 | 87609315426 | 2355.247 | 0.000 | 2355.247 | 467053611 | 12.55605 | 0.00000 | 12.55605 | 206.40667 | 0.0108217 | 19073.48 | 20089.64 | 334.6763156 | -| S1b | 37190655 | 1.0000000 | 85474784067 | 2298.287 | 0.000 | 2298.287 | 466807667 | 12.55175 | 0.00000 | 12.55175 | 149.44599 | 0.0065202 | 22920.31 | 25093.04 | 176.5661465 | -| S1c | 37195162 | 1.0000000 | 86086185363 | 2314.446 | 0.000 | 2314.446 | 466843147 | 12.55118 | 0.00000 | 12.55118 | 165.60516 | 0.0059532 | 27817.85 | 30805.50 | 132.0547739 | -| S2NoCD | 22074342 | 0.5934433 | 58922537505 | 2669.277 | 1389.169 | 2148.841 | 270895360 | 12.27196 | 12.94411 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S2a | 22077777 | 0.5935356 | 62347138314 | 2823.977 | 1389.169 | 2240.779 | 271063504 | 12.27766 | 12.94411 | 12.54855 | 91.93817 | 0.0033250 | 27650.44 | 27108.82 | 74.3210751 | -| S3NoCD | 17254548 | 0.4638687 | 50064966233 | 2901.552 | 1497.584 | 2148.841 | 193797357 | 11.23167 | 13.68174 | 12.54523 | 0.00000 | 0.0000000 | NaN | NaN | 0.0084027 | -| S3a | 17251608 | 0.4637896 | 52066304895 | 3018.055 | 1497.584 | 2202.763 | 193847860 | 11.23651 | 13.68174 | 12.54767 | 53.92205 | 0.0024391 | 22107.45 | 24063.44 | 68.0408589 | -| S3b | 17246874 | 0.4636624 | 53626126689 | 3109.324 | 1497.584 | 2244.887 | 193956939 | 11.24592 | 13.68174 | 12.55234 | 96.04666 | 0.0071128 | 13503.33 | 14580.18 | 259.6024694 | -| S3c | 17246125 | 0.4636422 | 52687996543 | 3055.063 | 1497.584 | 2219.697 | 193867414 | 11.24122 | 13.68174 | 12.55021 | 70.85627 | 0.0049815 | 14223.79 | 16078.26 | 178.2287927 | -| S3d | 17255729 | 0.4639004 | 52823751959 | 3061.230 | 1497.584 | 2222.960 | 193917114 | 11.23784 | 13.68174 | 12.54801 | 74.11923 | 0.0027851 | 26612.42 | 25873.76 | 65.1460215 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 933240063 | 12.54547 | 0.00000 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74386318 | 1.0000000 | 175298229824 | 2356.592 | 0.000 | 2356.592 | 934033198 | 12.55652 | 0.00000 | 12.55652 | 206.72538 | 0.0110449 | 18716.85 | 19145.74 | 345.51881 | +| S1b | 74385413 | 1.0000000 | 170952563916 | 2298.200 | 0.000 | 2298.200 | 933637487 | 12.55135 | 0.00000 | 12.55135 | 148.33311 | 0.0058779 | 25235.73 | 26468.96 | 145.56189 | +| S1c | 74390720 | 1.0000000 | 171904343832 | 2310.830 | 0.000 | 2310.830 | 933570750 | 12.54956 | 0.00000 | 12.54956 | 160.96350 | 0.0040854 | 39399.80 | 42521.81 | 43.30591 | +| S2NoCD | 44157029 | 0.5935995 | 117807957835 | 2667.932 | 1393.167 | 2149.867 | 541828917 | 12.27050 | 12.94711 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44154576 | 0.5935665 | 124844786047 | 2827.448 | 1393.167 | 2244.508 | 542208652 | 12.27978 | 12.94711 | 12.55101 | 94.64148 | 0.0055317 | 17108.96 | 17185.88 | 181.94301 | +| S3NoCD | 34491937 | 0.4636724 | 99999943602 | 2899.227 | 1502.021 | 2149.867 | 387401839 | 11.23166 | 13.68131 | 12.54547 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34494037 | 0.4637007 | 104115381916 | 3018.359 | 1502.021 | 2205.148 | 387590904 | 11.23646 | 13.68131 | 12.54763 | 55.28112 | 0.0021554 | 25648.14 | 24833.08 | 52.48718 | +| S3b | 34509196 | 0.4639044 | 107308147373 | 3109.552 | 1502.021 | 2247.762 | 388040453 | 11.24455 | 13.68131 | 12.55088 | 97.89513 | 0.0054106 | 18093.14 | 16319.03 | 172.63598 | +| S3c | 34504471 | 0.4638409 | 105270593424 | 3050.926 | 1502.021 | 2220.467 | 387852045 | 11.24063 | 13.68131 | 12.54922 | 70.59986 | 0.0037469 | 18842.32 | 16916.05 | 116.74399 | +| S3d | 34501231 | 0.4637974 | 105602366018 | 3060.829 | 1502.021 | 2224.992 | 387776869 | 11.23951 | 13.68131 | 12.54881 | 75.12527 | 0.0033322 | 22545.40 | 20600.86 | 91.48361 | ![](../../outputs/Sen3_30_Med_Adherence_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277801 | 0.1541410 | 0.2732173 | 0.0911566 | 0.4030472 | 0.0760263 | 0.1284096 | 0.0111267 | 0.8424613 | 0.0461119 | 0.0491189 | 0.0110335 | 0.0019273 | 0.3999881 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240553 | 0.1447802 | 0.2157515 | 0.0856247 | 0.4086320 | 0.0767122 | 0.1293709 | 0.0112159 | 0.8424572 | 0.0461045 | 0.0491178 | 0.0110465 | 0.0019286 | 0.2945268 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229349 | 0.1422163 | 0.1962587 | 0.0839634 | 0.4092320 | 0.0769957 | 0.1299784 | 0.0112125 | 0.8424873 | 0.0461079 | 0.0491353 | 0.0110154 | 0.0019116 | 0.2602946 | -| S2NoCD | 0.5934433 | 0.5822732 | 0.7055457 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935356 | 0.5822958 | 0.7060348 | 0.0214261 | 0.1433997 | 0.2089133 | 0.0847853 | 0.4076552 | 0.0767471 | 0.1292182 | 0.0111992 | 0.8425444 | 0.0460948 | 0.0491128 | 0.0109898 | 0.0019109 | 0.2776121 | -| S3NoCD | 0.4638687 | 0.4156354 | 0.5870736 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4637896 | 0.4156229 | 0.5868096 | 0.0197697 | 0.1380286 | 0.1714296 | 0.0812364 | 0.4112879 | 0.0772285 | 0.1300383 | 0.0112027 | 0.8426261 | 0.0461014 | 0.0490230 | 0.0109954 | 0.0019093 | 0.2168391 | -| S3b | 0.4636624 | 0.4156278 | 0.5873096 | 0.0217273 | 0.1440757 | 0.2123156 | 0.0853238 | 0.4076544 | 0.0766218 | 0.1293406 | 0.0111731 | 0.8425735 | 0.0461000 | 0.0490636 | 0.0110097 | 0.0019108 | 0.2840923 | -| S3c | 0.4636422 | 0.4155696 | 0.5876213 | 0.0206711 | 0.1409315 | 0.1917630 | 0.0832429 | 0.4099172 | 0.0770213 | 0.1297097 | 0.0111987 | 0.8425381 | 0.0460824 | 0.0491061 | 0.0110204 | 0.0019145 | 0.2493205 | -| S3d | 0.4639004 | 0.4157123 | 0.5874098 | 0.0202417 | 0.1395900 | 0.1822885 | 0.0822922 | 0.4104446 | 0.0770251 | 0.1298089 | 0.0112098 | 0.8425700 | 0.0461324 | 0.0490486 | 0.0110024 | 0.0019036 | 0.2342313 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277770 | 0.1541676 | 0.2735725 | 0.0911068 | 0.4036872 | 0.0760433 | 0.1284919 | 0.0111234 | 0.8424045 | 0.0461250 | 0.0491350 | 0.0110626 | 0.0019277 | 0.4003768 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240246 | 0.1449184 | 0.2159908 | 0.0856256 | 0.4082615 | 0.0767149 | 0.1294255 | 0.0111919 | 0.8424441 | 0.0461406 | 0.0491198 | 0.0110327 | 0.0019206 | 0.2943838 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229387 | 0.1419011 | 0.1959119 | 0.0838224 | 0.4094144 | 0.0768280 | 0.1296761 | 0.0111991 | 0.8425663 | 0.0460770 | 0.0490825 | 0.0110176 | 0.0019137 | 0.2600889 | +| S2NoCD | 0.5935995 | 0.5823361 | 0.7054688 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5935665 | 0.5824146 | 0.7059463 | 0.0213966 | 0.1438505 | 0.2094804 | 0.0850851 | 0.4086675 | 0.0767385 | 0.1294165 | 0.0112173 | 0.8425126 | 0.0461064 | 0.0490974 | 0.0110198 | 0.0019173 | 0.2779271 | +| S3NoCD | 0.4636724 | 0.4154340 | 0.5860893 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4637007 | 0.4155277 | 0.5865311 | 0.0197899 | 0.1383033 | 0.1717111 | 0.0814794 | 0.4121234 | 0.0772548 | 0.1301283 | 0.0112118 | 0.8425199 | 0.0460735 | 0.0491517 | 0.0110056 | 0.0019051 | 0.2173159 | +| S3b | 0.4639044 | 0.4157857 | 0.5876752 | 0.0217416 | 0.1441790 | 0.2124183 | 0.0853294 | 0.4094186 | 0.0768062 | 0.1294332 | 0.0111818 | 0.8424143 | 0.0460965 | 0.0491883 | 0.0110409 | 0.0019176 | 0.2844185 | +| S3c | 0.4638409 | 0.4156951 | 0.5869250 | 0.0206754 | 0.1410634 | 0.1917068 | 0.0833411 | 0.4105793 | 0.0769845 | 0.1297108 | 0.0112077 | 0.8424894 | 0.0460833 | 0.0491418 | 0.0110239 | 0.0019170 | 0.2496308 | +| S3d | 0.4637974 | 0.4156677 | 0.5868810 | 0.0202585 | 0.1397122 | 0.1824904 | 0.0824625 | 0.4112144 | 0.0771280 | 0.1298555 | 0.0112228 | 0.8424917 | 0.0460937 | 0.0491366 | 0.0110229 | 0.0019114 | 0.2345851 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 13.28409 hours + ## Time difference of 1.186785 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util3yrs.md index 7307578..fb45aca 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 0.01 Treatment Utility ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466402566 | 12.539 | 624797.3 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466462719 | 12.540 | 624855.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466432643 | 12.540 | 624826.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195779 | 626218800 | 71281372 | 186100281 | 33119195 | 13388772 | 0.026 | 0.159 | 0.310 | 0.094 | 14905588 | 2814123 | 4756454 | 412031 | 0.209 | 0.039 | 0.067 | 0.006 | 527524487 | 28873365 | 30786968 | 6925999 | 1208772 | 90753454326 | 2439.886 | 466710529 | 12.547 | 624930.4 | 292.777 | 0.009 | 34372.28 | 133.114 | -| S1b | 37200476 | 626144172 | 71252445 | 188422793 | 23802097 | 13372758 | 0.022 | 0.148 | 0.240 | 0.088 | 15103031 | 2841048 | 4796549 | 415612 | 0.212 | 0.040 | 0.067 | 0.006 | 527481440 | 28877807 | 30767692 | 6915814 | 1204950 | 87878153022 | 2362.286 | 466602622 | 12.543 | 624783.8 | 215.177 | 0.004 | 53355.61 | \-13.533 | -| S1c | 37192813 | 625960445 | 71159107 | 189176712 | 20537777 | 13372239 | 0.020 | 0.144 | 0.214 | 0.085 | 15172732 | 2850944 | 4816068 | 416845 | 0.213 | 0.040 | 0.068 | 0.006 | 527395566 | 28830750 | 30734973 | 6903078 | 1206962 | 88797560537 | 2387.492 | 466450153 | 12.541 | 624682.8 | 240.384 | 0.003 | 95476.24 | \-114.497 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 932792068 | 12.539 | 624823.2 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 932835892 | 12.540 | 624851.7 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 932813980 | 12.540 | 624837.4 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74380275 | 1252107231 | 142568770 | 372100831 | 66270673 | 26745802 | 0.026 | 0.159 | 0.310 | 0.094 | 29815042 | 5625494 | 9500837 | 824680.0 | 0.209 | 0.039 | 0.067 | 0.006 | 1054730269 | 57758498 | 61574433 | 13835312 | 2423951 | 181401075128 | 2438.833 | 933176477 | 12.546 | 624862.2 | 290.796 | 0.007 | 44083.87 | 39.025 | +| S1b | 74383024 | 1252030978 | 142410670 | 376764647 | 47607118 | 26748888 | 0.022 | 0.148 | 0.241 | 0.088 | 30192660 | 5683507 | 9596337 | 830158.0 | 0.212 | 0.040 | 0.067 | 0.006 | 1054810413 | 57710159 | 61499603 | 13827904 | 2405886 | 175747140584 | 2362.732 | 933016459 | 12.543 | 624807.6 | 214.694 | 0.004 | 53923.28 | \-15.620 | +| S1c | 74393892 | 1252166867 | 142379318 | 378416895 | 41063274 | 26758496 | 0.020 | 0.144 | 0.214 | 0.085 | 30350312 | 5702044 | 9621386 | 828456.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054965444 | 57726777 | 61483651 | 13803995 | 2400849 | 177409072797 | 2384.726 | 933081226 | 12.542 | 624737.5 | 236.689 | 0.003 | 78383.03 | \-85.707 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ------: | -------------: | -| S2NoCD | 22078563 | 364522749 | 50166624 | 110968095 | 9653606 | 7738507 | 0.017 | 0.141 | 0.159 | 0.087 | 11438971 | 2125413 | 3543389 | 304919 | 0.228 | 0.042 | 0.071 | 0.006 | 298790021 | 18633807 | 22502661 | 5543543 | 1025792 | 58731887921 | 2660.132 | 270758372 | 12.263 | 610510.1 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077788 | 364622606 | 50226923 | 108797477 | 18511084 | 7734136 | 0.023 | 0.157 | 0.269 | 0.097 | 11192847 | 2087413 | 3500787 | 300763 | 0.223 | 0.042 | 0.070 | 0.006 | 298828425 | 18622586 | 22524521 | 5579724 | 1036307 | 63840415723 | 2891.613 | 270883900 | 12.270 | 610584.5 | 231.481 | 0.006 | 37847.2 | 74.329 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44156404 | 729084497 | 100330760 | 221928932 | 19330952 | 15481473 | 0.017 | 0.142 | 0.159 | 0.087 | 22917076 | 4253860 | 7098458 | 609501 | 0.228 | 0.042 | 0.071 | 0.006 | 597619551 | 37246010 | 44990133 | 11123560 | 2050468 | 117605933755 | 2663.395 | 541539872 | 12.264 | 610543.1 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44164773 | 729329891 | 100492049 | 217625447 | 37010683 | 15485858 | 0.023 | 0.157 | 0.269 | 0.097 | 22383331 | 4181008 | 7006346 | 603148 | 0.223 | 0.042 | 0.070 | 0.006 | 597700094 | 37284225 | 45068617 | 11147317 | 2064302 | 127735308298 | 2892.244 | 541836401 | 12.269 | 610533.8 | 228.849 | 0.004 | 52127.75 | \-9.341 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17243525 | 260017880 | 41691838 | 80059027 | 7819384 | 5815322 | 0.018 | 0.137 | 0.154 | 0.086 | 9754415 | 1816466 | 3038101 | 261338 | 0.234 | 0.044 | 0.073 | 0.006 | 207433146 | 15294590 | 18682841 | 4808648 | 895345 | 49933527334 | 2895.784 | 193546783 | 11.224 | 558320.0 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17245589 | 260114351 | 41778508 | 79305268 | 11012874 | 5816924 | 0.021 | 0.144 | 0.204 | 0.091 | 9648241 | 1803612 | 3027939 | 260144 | 0.231 | 0.043 | 0.072 | 0.006 | 207442211 | 15303706 | 18733677 | 4824249 | 900624 | 53097071421 | 3078.878 | 193630822 | 11.228 | 558313.4 | 183.094 | 0.004 | 51871.99 | \-6.608 | -| S3b | 17248093 | 260143539 | 41765340 | 77789956 | 17179218 | 5809490 | 0.027 | 0.156 | 0.293 | 0.099 | 9481831 | 1779958 | 2992091 | 258625 | 0.227 | 0.043 | 0.072 | 0.006 | 207483725 | 15287322 | 18724587 | 4837601 | 899769 | 55163743515 | 3198.252 | 193698483 | 11.230 | 558308.7 | 302.468 | 0.006 | 51947.57 | \-11.340 | -| S3c | 17249568 | 260123652 | 41796963 | 78552778 | 14093542 | 5811921 | 0.024 | 0.150 | 0.249 | 0.095 | 9556493 | 1794042 | 3007246 | 258985 | 0.229 | 0.043 | 0.072 | 0.006 | 207434647 | 15324709 | 18727689 | 4823824 | 902793 | 53820717606 | 3120.120 | 193662078 | 11.227 | 558233.3 | 224.336 | 0.003 | 81524.39 | \-86.748 | -| S3d | 17250373 | 260166499 | 41788451 | 78909896 | 12694599 | 5812281 | 0.023 | 0.147 | 0.229 | 0.093 | 9596955 | 1798651 | 3013620 | 260246 | 0.230 | 0.043 | 0.072 | 0.006 | 207483596 | 15310784 | 18731510 | 4829309 | 900292 | 54140141633 | 3138.491 | 193684186 | 11.228 | 558252.8 | 242.707 | 0.004 | 69157.79 | \-67.234 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34500334 | 520264617 | 83469550 | 160191877 | 15617539 | 11630123 | 0.018 | 0.137 | 0.154 | 0.086 | 19525292 | 3631989 | 6073558 | 522424 | 0.234 | 0.044 | 0.073 | 0.006 | 415002016 | 30608834 | 37422882 | 9624470 | 1788687 | 99842281258 | 2893.951 | 387259113 | 11.225 | 558345.7 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34507415 | 520428951 | 83482576 | 158676520 | 22030098 | 11639538 | 0.021 | 0.144 | 0.204 | 0.091 | 19287934 | 3609226 | 6045313 | 521405 | 0.231 | 0.043 | 0.072 | 0.006 | 415152628 | 30610103 | 37407716 | 9641236 | 1794702 | 106095806862 | 3074.580 | 387430324 | 11.227 | 558298.0 | 180.629 | 0.003 | 67950.91 | \-47.718 | +| S3b | 34499539 | 520396932 | 83618002 | 155590263 | 34428826 | 11625591 | 0.027 | 0.156 | 0.293 | 0.099 | 18988453 | 3564625 | 5980823 | 516662 | 0.227 | 0.043 | 0.072 | 0.006 | 414988556 | 30607762 | 37472866 | 9688489 | 1813970 | 110363699543 | 3198.991 | 387468230 | 11.231 | 558356.7 | 305.039 | 0.006 | 48264.94 | 10.966 | +| S3c | 34496334 | 520227370 | 83568351 | 157099275 | 28171361 | 11622564 | 0.024 | 0.150 | 0.249 | 0.095 | 19145218 | 3585036 | 6010150 | 518449 | 0.229 | 0.043 | 0.072 | 0.006 | 414875686 | 30589301 | 37479876 | 9661353 | 1804425 | 107627143927 | 3119.959 | 387308369 | 11.228 | 558256.2 | 226.008 | 0.003 | 82803.73 | \-89.536 | +| S3d | 34507664 | 520495018 | 83555471 | 157877292 | 25364366 | 11630839 | 0.023 | 0.147 | 0.229 | 0.093 | 19209915 | 3595849 | 6028084 | 520340 | 0.230 | 0.043 | 0.072 | 0.006 | 415141325 | 30594930 | 37472224 | 9653084 | 1805226 | 108255487965 | 3137.143 | 387489230 | 11.229 | 558316.7 | 243.192 | 0.004 | 56764.02 | \-28.979 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S1a | 37195779 | 90753454326 | 2439.886 | 466710529 | 12.547 | 34372.28 | 133.114 | -| S2a | 22077788 | 63840415723 | 2891.613 | 270883900 | 12.270 | 37847.20 | 74.329 | -| S1NoCD | 37196486 | 79864892645 | 2147.109 | 466402566 | 12.539 | NaN | 0.000 | -| S2NoCD | 22078563 | 58731887921 | 2660.132 | 270758372 | 12.263 | NaN | 0.000 | -| S3NoCD | 17243525 | 49933527334 | 2895.784 | 193546783 | 11.224 | NaN | 0.000 | -| S3a | 17245589 | 53097071421 | 3078.878 | 193630822 | 11.228 | 51871.99 | \-6.608 | -| S3b | 17248093 | 55163743515 | 3198.252 | 193698483 | 11.230 | 51947.57 | \-11.340 | -| S1b | 37200476 | 87878153022 | 2362.286 | 466602622 | 12.543 | 53355.61 | \-13.533 | -| S3d | 17250373 | 54140141633 | 3138.491 | 193684186 | 11.228 | 69157.79 | \-67.234 | -| S3c | 17249568 | 53820717606 | 3120.120 | 193662078 | 11.227 | 81524.39 | \-86.748 | -| S1c | 37192813 | 88797560537 | 2387.492 | 466450153 | 12.541 | 95476.24 | \-114.497 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S1a | 74380275 | 181401075128 | 2438.833 | 933176477 | 12.546 | 44083.87 | 39.025 | +| S3b | 34499539 | 110363699543 | 3198.991 | 387468230 | 11.231 | 48264.94 | 10.966 | +| S1NoCD | 74388747 | 159789813678 | 2148.037 | 932792068 | 12.539 | NaN | 0.000 | +| S2NoCD | 44156404 | 117605933755 | 2663.395 | 541539872 | 12.264 | NaN | 0.000 | +| S3NoCD | 34500334 | 99842281258 | 2893.951 | 387259113 | 11.225 | NaN | 0.000 | +| S2a | 44164773 | 127735308298 | 2892.244 | 541836401 | 12.269 | 52127.75 | \-9.341 | +| S1b | 74383024 | 175747140584 | 2362.732 | 933016459 | 12.543 | 53923.28 | \-15.620 | +| S3d | 34507664 | 108255487965 | 3137.143 | 387489230 | 11.229 | 56764.02 | \-28.979 | +| S3a | 34507415 | 106095806862 | 3074.580 | 387430324 | 11.227 | 67950.91 | \-47.718 | +| S1c | 74393892 | 177409072797 | 2384.726 | 933081226 | 12.542 | 78383.03 | \-85.707 | +| S3c | 34496334 | 107627143927 | 3119.959 | 387308369 | 11.228 | 82803.73 | \-89.536 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | --------: | -------: | ------------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466432643 | 12.53950 | 0.00000 | 12.53950 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37195779 | 1.0000000 | 90753454326 | 2439.886 | 0.000 | 2439.886 | 466710529 | 12.54741 | 0.00000 | 12.54741 | 291.04522 | 0.0079009 | 36836.96 | 34372.28 | 103.9998913 | -| S1b | 37200476 | 1.0000000 | 87878153022 | 2362.286 | 0.000 | 2362.286 | 466602622 | 12.54292 | 0.00000 | 12.54292 | 213.44510 | 0.0034160 | 62484.70 | 53355.61 | \-42.6472017 | -| S1c | 37192813 | 1.0000000 | 88797560537 | 2387.492 | 0.000 | 2387.492 | 466450153 | 12.54141 | 0.00000 | 12.54141 | 238.65184 | 0.0019008 | 125552.98 | 95476.24 | \-143.6115459 | -| S2NoCD | 22078563 | 0.5935568 | 58731887921 | 2660.132 | 1402.167 | 2148.841 | 270758372 | 12.26341 | 12.94271 | 12.53950 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083989 | -| S2a | 22077788 | 0.5935359 | 63840415723 | 2891.613 | 1402.167 | 2286.207 | 270883900 | 12.26952 | 12.94271 | 12.54315 | 137.36611 | 0.0036443 | 37693.02 | 37847.20 | 44.8591713 | -| S3NoCD | 17243525 | 0.4635723 | 49933527334 | 2895.784 | 1503.344 | 2148.841 | 193546783 | 11.22432 | 13.67607 | 12.53950 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083989 | -| S3a | 17245589 | 0.4636278 | 53097071421 | 3078.878 | 1503.344 | 2233.805 | 193630822 | 11.22785 | 13.67607 | 12.54101 | 84.96483 | 0.0015004 | 56626.67 | 51871.98 | \-9.9345121 | -| S3b | 17248093 | 0.4636951 | 55163743515 | 3198.252 | 1503.344 | 2289.264 | 193698483 | 11.23014 | 13.67607 | 12.54190 | 140.42373 | 0.0023988 | 58539.12 | 51947.57 | \-20.4752539 | -| S3c | 17249568 | 0.4637348 | 53820717606 | 3120.120 | 1503.344 | 2253.099 | 193662078 | 11.22707 | 13.67607 | 12.54038 | 104.25841 | 0.0008778 | 118775.49 | 81524.39 | \-60.3611513 | -| S3d | 17250373 | 0.4637564 | 54140141633 | 3138.491 | 1503.344 | 2261.654 | 193684186 | 11.22783 | 13.67607 | 12.54068 | 112.81322 | 0.0011762 | 95915.91 | 69157.79 | \-53.9964255 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 932813980 | 12.53975 | 0.00000 | 12.53975 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | +| S1a | 74380275 | 1.0000000 | 181401075128 | 2438.833 | 0.000 | 2438.833 | 933176477 | 12.54602 | 0.00000 | 12.54602 | 288.96609 | 0.0062747 | 46052.46 | 44083.87 | 24.769713 | +| S1b | 74383024 | 1.0000000 | 175747140584 | 2362.732 | 0.000 | 2362.732 | 933016459 | 12.54341 | 0.00000 | 12.54341 | 212.86487 | 0.0036598 | 58163.34 | 53923.28 | \-29.876018 | +| S1c | 74393892 | 1.0000000 | 177409072797 | 2384.726 | 0.000 | 2384.726 | 933081226 | 12.54244 | 0.00000 | 12.54244 | 234.85933 | 0.0026979 | 87051.28 | 78383.03 | \-99.962220 | +| S2NoCD | 44156404 | 0.5935911 | 117605933755 | 2663.395 | 1399.821 | 2149.867 | 541539872 | 12.26413 | 12.94230 | 12.53975 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | +| S2a | 44164773 | 0.5937036 | 127735308298 | 2892.244 | 1399.821 | 2285.878 | 541836401 | 12.26852 | 12.94230 | 12.54228 | 136.01091 | 0.0025302 | 53755.86 | 52127.75 | \-9.502914 | +| S3NoCD | 34500334 | 0.4637853 | 99842281258 | 2893.951 | 1506.290 | 2149.867 | 387259113 | 11.22479 | 13.67708 | 12.53975 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | +| S3a | 34507415 | 0.4638805 | 106095806862 | 3074.580 | 1506.290 | 2233.789 | 387430324 | 11.22745 | 13.67708 | 12.54075 | 83.92228 | 0.0009997 | 83950.22 | 67950.91 | \-33.938917 | +| S3b | 34499539 | 0.4637746 | 110363699543 | 3198.991 | 1506.290 | 2291.322 | 387468230 | 11.23111 | 13.67708 | 12.54270 | 141.45471 | 0.0029573 | 47832.19 | 48264.94 | 6.410878 | +| S3c | 34496334 | 0.4637315 | 107627143927 | 3119.959 | 1506.290 | 2254.599 | 387308369 | 11.22752 | 13.67708 | 12.54114 | 104.73230 | 0.0013976 | 74937.75 | 82803.73 | \-34.852769 | +| S3d | 34507664 | 0.4638839 | 108255487965 | 3137.143 | 1506.290 | 2262.817 | 387489230 | 11.22908 | 13.67708 | 12.54149 | 112.94966 | 0.0017458 | 64699.35 | 56764.02 | \-25.661565 | ![](../../outputs/Sen4_01_Treat_Util_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264130 | 0.1594355 | 0.3100498 | 0.0943012 | 0.4007333 | 0.0756571 | 0.1278762 | 0.0110774 | 0.8423964 | 0.0461075 | 0.0491633 | 0.0110600 | 0.0019303 | 0.4646262 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216055 | 0.1480604 | 0.2404960 | 0.0875941 | 0.4059903 | 0.0763713 | 0.1289378 | 0.0111722 | 0.8424281 | 0.0461201 | 0.0491384 | 0.0110451 | 0.0019244 | 0.3340531 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201493 | 0.1442413 | 0.2143855 | 0.0852093 | 0.4079480 | 0.0766531 | 0.1294892 | 0.0112077 | 0.8425382 | 0.0460584 | 0.0491005 | 0.0110280 | 0.0019282 | 0.2886177 | -| S2NoCD | 0.5935568 | 0.5823097 | 0.7053578 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935359 | 0.5824692 | 0.7062056 | 0.0223351 | 0.1468614 | 0.2290467 | 0.0868672 | 0.4071715 | 0.0764348 | 0.1292457 | 0.0111517 | 0.8425215 | 0.0460676 | 0.0490957 | 0.0110473 | 0.0019254 | 0.3104013 | -| S3NoCD | 0.4635723 | 0.4153676 | 0.5861997 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4636278 | 0.4155217 | 0.5874183 | 0.0201358 | 0.1392626 | 0.1805149 | 0.0822287 | 0.4109128 | 0.0771069 | 0.1301110 | 0.0112307 | 0.8424794 | 0.0461006 | 0.0491419 | 0.0110143 | 0.0019170 | 0.2306846 | -| S3b | 0.4636951 | 0.4155683 | 0.5872332 | 0.0226883 | 0.1466743 | 0.2326983 | 0.0870001 | 0.4064201 | 0.0764674 | 0.1291411 | 0.0111894 | 0.8425049 | 0.0460727 | 0.0491259 | 0.0110354 | 0.0019156 | 0.3174192 | -| S3c | 0.4637348 | 0.4155365 | 0.5876778 | 0.0213351 | 0.1429510 | 0.2072023 | 0.0845726 | 0.4084161 | 0.0768439 | 0.1295450 | 0.0111987 | 0.8424543 | 0.0461336 | 0.0491319 | 0.0110136 | 0.0019205 | 0.2739520 | -| S3d | 0.4637564 | 0.4156050 | 0.5875581 | 0.0207664 | 0.1413812 | 0.1952106 | 0.0835996 | 0.4094977 | 0.0769666 | 0.1297144 | 0.0112325 | 0.8424726 | 0.0461088 | 0.0491357 | 0.0110219 | 0.0019164 | 0.2543044 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264033 | 0.1593018 | 0.3099946 | 0.0940914 | 0.4008461 | 0.0756315 | 0.1277333 | 0.0110873 | 0.8423642 | 0.0461290 | 0.0491766 | 0.0110496 | 0.0019359 | 0.4648330 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216398 | 0.1482342 | 0.2406521 | 0.0877947 | 0.4059079 | 0.0764087 | 0.1290125 | 0.0111606 | 0.8424795 | 0.0460932 | 0.0491199 | 0.0110444 | 0.0019216 | 0.3342946 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201517 | 0.1441110 | 0.2141912 | 0.0851720 | 0.4079678 | 0.0766467 | 0.1293303 | 0.0111361 | 0.8425119 | 0.0461015 | 0.0491018 | 0.0110241 | 0.0019174 | 0.2884076 | +| S2NoCD | 0.5935911 | 0.5823656 | 0.7051165 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5937036 | 0.5825616 | 0.7062500 | 0.0223572 | 0.1465203 | 0.2287835 | 0.0867962 | 0.4069072 | 0.0764858 | 0.1291620 | 0.0111850 | 0.8424534 | 0.0460995 | 0.0491621 | 0.0110233 | 0.0019191 | 0.3102030 | +| S3NoCD | 0.4637853 | 0.4155681 | 0.5866172 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4638805 | 0.4156993 | 0.5867088 | 0.0201156 | 0.1395918 | 0.1808230 | 0.0824771 | 0.4108939 | 0.0771596 | 0.1300215 | 0.0112568 | 0.8425660 | 0.0460728 | 0.0490892 | 0.0110179 | 0.0019129 | 0.2311946 | +| S3b | 0.4637746 | 0.4156737 | 0.5876605 | 0.0227032 | 0.1471017 | 0.2332507 | 0.0873282 | 0.4068980 | 0.0765657 | 0.1291642 | 0.0111939 | 0.8424573 | 0.0460719 | 0.0491421 | 0.0110558 | 0.0019283 | 0.3181560 | +| S3c | 0.4637315 | 0.4155383 | 0.5873116 | 0.0213262 | 0.1432680 | 0.2074859 | 0.0848645 | 0.4090175 | 0.0768424 | 0.1295624 | 0.0112182 | 0.8424856 | 0.0460621 | 0.0491521 | 0.0110349 | 0.0019208 | 0.2742435 | +| S3d | 0.4638839 | 0.4157521 | 0.5872211 | 0.0207546 | 0.1415673 | 0.1954816 | 0.0837051 | 0.4098442 | 0.0769796 | 0.1297896 | 0.0112424 | 0.8425108 | 0.0460587 | 0.0491390 | 0.0110271 | 0.0019212 | 0.2545329 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 17.10892 hours + ## Time difference of 1.291363 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util5yrs.md index 2cf37e3..bd11d7a 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen4_01_Treat_Util5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 0.01 Treatment Utility ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD2 | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466402566 | 12.539 | 624797.3 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466462719 | 12.540 | 624855.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466432643 | 12.540 | 624826.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37197502 | 626089853 | 71222084 | 122776626 | 28487983 | 16327137 | 0.028 | 0.154 | 0.273 | 0.091 | 14992350 | 2827989 | 4776515 | 413886 | 0.211 | 0.040 | 0.067 | 0.006 | 527456443 | 28870190 | 30752817 | 6907934 | 1206659 | 87609315426 | 2355.247 | 466595032 | 12.544 | 624830.7 | 204.675 | 0.004 | 56888.54 | \-24.784 | -| S1b | 37190655 | 625992698 | 71214502 | 123717512 | 20974578 | 16327973 | 0.024 | 0.145 | 0.216 | 0.086 | 15197291 | 2852978 | 4811387 | 417126 | 0.213 | 0.040 | 0.068 | 0.006 | 527372066 | 28861102 | 30747408 | 6915037 | 1207305 | 85474784067 | 2298.287 | 466468382 | 12.543 | 624832.9 | 147.714 | 0.003 | 59043.76 | \-22.625 | -| S1c | 37195162 | 626110982 | 71210037 | 124047387 | 18535585 | 16324587 | 0.023 | 0.142 | 0.196 | 0.084 | 15221449 | 2863867 | 4834566 | 417049 | 0.214 | 0.040 | 0.068 | 0.006 | 527490541 | 28868640 | 30764128 | 6896850 | 1196858 | 86086185363 | 2314.446 | 466543277 | 12.543 | 624841.4 | 163.873 | 0.003 | 54705.98 | \-14.097 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | +| S1NoCD2 | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 932792068 | 12.539 | 624823.2 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 932835892 | 12.540 | 624851.7 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 932813980 | 12.540 | 624837.4 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386318 | 1252092577 | 142511621 | 245523949 | 57058349 | 32655914 | 0.028 | 0.154 | 0.274 | 0.091 | 30028808 | 5656584 | 9558038 | 827432.0 | 0.211 | 0.040 | 0.067 | 0.006 | 1054768469 | 57752767 | 61521629 | 13851433 | 2413714 | 175298229824 | 2356.592 | 933114770 | 12.544 | 624852.0 | 204.896 | 0.004 | 49922.89 | 0.316 | +| S1b | 74385413 | 1252007176 | 142455061 | 247448362 | 41936466 | 32651747 | 0.024 | 0.145 | 0.216 | 0.086 | 30368698 | 5706469 | 9627370 | 832514.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054746061 | 57768304 | 61498391 | 13812986 | 2404656 | 170952563916 | 2298.200 | 932959012 | 12.542 | 624813.3 | 146.504 | 0.002 | 67733.79 | \-38.357 | +| S1c | 74390720 | 1252048091 | 142295860 | 248074520 | 37009576 | 32668233 | 0.023 | 0.142 | 0.196 | 0.084 | 30456632 | 5715293 | 9646702 | 833108.0 | 0.214 | 0.040 | 0.068 | 0.006 | 1054933501 | 57690667 | 61453687 | 13794504 | 2396041 | 171904343832 | 2310.830 | 932972380 | 12.542 | 624765.0 | 159.134 | 0.001 | 109908.25 | \-86.740 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22074342 | 364499893 | 50179989 | 72492409 | 9769650 | 9434235 | 0.021 | 0.142 | 0.160 | 0.087 | 11472370 | 2126666 | 3551252 | 304704 | 0.229 | 0.042 | 0.071 | 0.006 | 298757005 | 18626945 | 22501053 | 5562438 | 1027303 | 58922537505 | 2669.277 | 270734518 | 12.265 | 610564.2 | 0.0 | 0.000 | NaN | 0.000 | -| S2a | 22077777 | 364514086 | 50214779 | 71673455 | 16290550 | 9435494 | 0.025 | 0.153 | 0.241 | 0.095 | 11245330 | 2100490 | 3507989 | 302346 | 0.224 | 0.042 | 0.070 | 0.006 | 298734836 | 18629376 | 22530917 | 5562183 | 1028646 | 62347138314 | 2823.977 | 270793672 | 12.265 | 610448.1 | 154.7 | 0.001 | 200611.5 | \-116.143 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44157029 | 729047563 | 100380900 | 145000421 | 19524492 | 18863743 | 0.021 | 0.142 | 0.160 | 0.087 | 22925265 | 4254784 | 7099566 | 609563 | 0.228 | 0.042 | 0.071 | 0.006 | 597538799 | 37245010 | 45040554 | 11117169 | 2054803 | 117807957835 | 2667.932 | 541507456 | 12.263 | 610493.2 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44154576 | 729145856 | 100448839 | 143361789 | 32595478 | 18878233 | 0.025 | 0.154 | 0.242 | 0.095 | 22519648 | 4200194 | 7025459 | 605531 | 0.224 | 0.042 | 0.070 | 0.006 | 597564735 | 37286040 | 45033303 | 11135908 | 2066352 | 124844786047 | 2827.448 | 541668368 | 12.268 | 610549.9 | 159.516 | 0.004 | 36877.58 | 56.762 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17254548 | 260185517 | 41753987 | 52456874 | 7922835 | 7061036 | 0.022 | 0.137 | 0.155 | 0.086 | 9767617 | 1818208 | 3040076 | 262205 | 0.234 | 0.044 | 0.073 | 0.006 | 207533583 | 15301679 | 18724752 | 4815426 | 897482 | 50064966233 | 2901.552 | 193666885 | 11.224 | 558303.8 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17251608 | 260177738 | 41735217 | 52193377 | 10112286 | 7056308 | 0.024 | 0.142 | 0.189 | 0.089 | 9673981 | 1809610 | 3026757 | 259927 | 0.232 | 0.043 | 0.073 | 0.006 | 207543323 | 15307443 | 18697708 | 4818609 | 897810 | 52066304895 | 3018.055 | 193680145 | 11.227 | 558321.3 | 116.503 | 0.003 | 43448.55 | 17.567 | -| S3b | 17246874 | 260180750 | 41770771 | 51592135 | 14901907 | 7060341 | 0.029 | 0.152 | 0.258 | 0.096 | 9537491 | 1786791 | 3000373 | 258790 | 0.228 | 0.043 | 0.072 | 0.006 | 207513062 | 15306657 | 18723252 | 4827550 | 898750 | 53626126689 | 3109.324 | 193709817 | 11.232 | 558470.2 | 207.773 | 0.007 | 27764.45 | 166.398 | -| S3c | 17246125 | 260144350 | 41792942 | 51894923 | 12432863 | 7060467 | 0.026 | 0.147 | 0.223 | 0.093 | 9621451 | 1801612 | 3014035 | 259735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459068 | 15294280 | 18748666 | 4834049 | 901039 | 52687996543 | 3055.063 | 193660757 | 11.229 | 558406.6 | 153.511 | 0.005 | 29944.51 | 102.815 | -| S3d | 17255729 | 260233694 | 41777900 | 52047317 | 11356970 | 7062160 | 0.025 | 0.144 | 0.207 | 0.091 | 9643777 | 1802264 | 3018596 | 260225 | 0.231 | 0.043 | 0.072 | 0.006 | 207557193 | 15328896 | 18715546 | 4823282 | 894293 | 52823751959 | 3061.230 | 193728621 | 11.227 | 558284.6 | 159.678 | 0.003 | 56834.99 | \-19.203 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34491937 | 520096794 | 83394436 | 104866546 | 15798844 | 14116443 | 0.022 | 0.137 | 0.154 | 0.086 | 19479590 | 3630576 | 6075819 | 523166 | 0.234 | 0.044 | 0.073 | 0.006 | 414917152 | 30599570 | 37365292 | 9614469 | 1790750 | 99999943602 | 2899.227 | 387141750 | 11.224 | 558306.9 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34494037 | 520214111 | 83457293 | 104351592 | 20245608 | 14129448 | 0.024 | 0.142 | 0.189 | 0.089 | 19332282 | 3614629 | 6055063 | 518761 | 0.232 | 0.043 | 0.073 | 0.006 | 414968911 | 30599997 | 37426814 | 9615582 | 1787056 | 104115381916 | 3018.359 | 387255177 | 11.227 | 558318.1 | 119.132 | 0.003 | 45732.73 | 11.116 | +| S3b | 34509196 | 520537138 | 83620081 | 103218767 | 29823148 | 14132996 | 0.029 | 0.152 | 0.258 | 0.096 | 19135380 | 3582069 | 6004729 | 516649 | 0.229 | 0.043 | 0.072 | 0.006 | 415119150 | 30640730 | 37483240 | 9661621 | 1802895 | 107308147373 | 3109.552 | 387545996 | 11.230 | 558401.6 | 210.326 | 0.006 | 34475.90 | 94.707 | +| S3c | 34504471 | 520423616 | 83513343 | 103824096 | 24853847 | 14121585 | 0.026 | 0.146 | 0.223 | 0.093 | 19220385 | 3595075 | 6024956 | 518536 | 0.230 | 0.043 | 0.072 | 0.006 | 415113845 | 30619979 | 37421385 | 9639642 | 1802009 | 105270593424 | 3050.926 | 387439707 | 11.229 | 558383.1 | 151.699 | 0.005 | 33281.70 | 76.203 | +| S3d | 34501231 | 520389346 | 83507084 | 104079260 | 22711874 | 14135933 | 0.025 | 0.144 | 0.207 | 0.091 | 19266710 | 3605577 | 6035420 | 519637 | 0.231 | 0.043 | 0.072 | 0.006 | 415086795 | 30631737 | 37413709 | 9638221 | 1794998 | 105602366018 | 3060.829 | 387400040 | 11.229 | 558368.5 | 161.602 | 0.004 | 36210.96 | 61.538 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | --------: | -------------: | -| S3b | 17246874 | 53626126689 | 3109.324 | 193709817 | 11.232 | 27764.45 | 166.398 | -| S3c | 17246125 | 52687996543 | 3055.063 | 193660757 | 11.229 | 29944.51 | 102.815 | -| S3a | 17251608 | 52066304895 | 3018.055 | 193680145 | 11.227 | 43448.55 | 17.567 | -| S1NoCD | 37197623 | 79996190237 | 2150.573 | 466462719 | 12.540 | NaN | 0.000 | -| S2NoCD | 22074342 | 58922537505 | 2669.277 | 270734518 | 12.265 | NaN | 0.000 | -| S3NoCD | 17254548 | 50064966233 | 2901.552 | 193666885 | 11.224 | NaN | 0.000 | -| S1c | 37195162 | 86086185363 | 2314.446 | 466543277 | 12.543 | 54705.98 | \-14.097 | -| S3d | 17255729 | 52823751959 | 3061.230 | 193728621 | 11.227 | 56834.99 | \-19.203 | -| S1b | 37190655 | 85474784067 | 2298.287 | 466468382 | 12.543 | 59043.76 | \-22.625 | -| S1a | 37197502 | 87609315426 | 2355.247 | 466595032 | 12.544 | 56888.54 | \-24.784 | -| S2a | 22077777 | 62347138314 | 2823.977 | 270793672 | 12.265 | 200611.52 | \-116.143 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | --------: | -------------: | +| S3b | 34509196 | 107308147373 | 3109.552 | 387545996 | 11.230 | 34475.90 | 94.707 | +| S3c | 34504471 | 105270593424 | 3050.926 | 387439707 | 11.229 | 33281.70 | 76.203 | +| S3d | 34501231 | 105602366018 | 3060.829 | 387400040 | 11.229 | 36210.96 | 61.538 | +| S2a | 44154576 | 124844786047 | 2827.448 | 541668368 | 12.268 | 36877.58 | 56.762 | +| S3a | 34494037 | 104115381916 | 3018.359 | 387255177 | 11.227 | 45732.73 | 11.116 | +| S1a | 74386318 | 175298229824 | 2356.592 | 933114770 | 12.544 | 49922.89 | 0.316 | +| S1NoCD | 74388425 | 160061317736 | 2151.697 | 932835892 | 12.540 | NaN | 0.000 | +| S2NoCD | 44157029 | 117807957835 | 2667.932 | 541507456 | 12.263 | NaN | 0.000 | +| S3NoCD | 34491937 | 99999943602 | 2899.227 | 387141750 | 11.224 | NaN | 0.000 | +| S1b | 74385413 | 170952563916 | 2298.200 | 932959012 | 12.542 | 67733.79 | \-38.357 | +| S1c | 74390720 | 171904343832 | 2310.830 | 932972380 | 12.542 | 109908.25 | \-86.740 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | --------: | --------: | -----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466432643 | 12.53950 | 0.00000 | 12.53950 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37197502 | 1.0000000 | 87609315426 | 2355.247 | 0.000 | 2355.247 | 466595032 | 12.54372 | 0.00000 | 12.54372 | 206.40667 | 0.0042147 | 48972.70 | 56888.54 | 4.3297998 | -| S1b | 37190655 | 1.0000000 | 85474784067 | 2298.287 | 0.000 | 2298.287 | 466468382 | 12.54262 | 0.00000 | 12.54262 | 149.44599 | 0.0031187 | 47919.60 | 59043.76 | 6.4880933 | -| S1c | 37195162 | 1.0000000 | 86086185363 | 2314.446 | 0.000 | 2314.446 | 466543277 | 12.54312 | 0.00000 | 12.54312 | 165.60516 | 0.0036124 | 45843.07 | 54705.98 | 15.0166295 | -| S2NoCD | 22074342 | 0.5934433 | 58922537505 | 2669.277 | 1389.169 | 2148.841 | 270734518 | 12.26467 | 12.94068 | 12.53950 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083989 | -| S2a | 22077777 | 0.5935356 | 62347138314 | 2823.977 | 1389.169 | 2240.779 | 270793672 | 12.26544 | 12.94068 | 12.53990 | 91.93817 | 0.0003953 | 232593.64 | 200611.52 | \-72.1660798 | -| S3NoCD | 17254548 | 0.4638687 | 50064966233 | 2901.552 | 1497.584 | 2148.841 | 193666885 | 11.22411 | 13.67761 | 12.53950 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083989 | -| S3a | 17251608 | 0.4637896 | 52066304895 | 3018.055 | 1497.584 | 2202.763 | 193680145 | 11.22679 | 13.67761 | 12.54094 | 53.92205 | 0.0014375 | 37510.21 | 43448.55 | 17.9628561 | -| S3b | 17246874 | 0.4636624 | 53626126689 | 3109.324 | 1497.584 | 2244.887 | 193709817 | 11.23159 | 13.67761 | 12.54348 | 96.04666 | 0.0039759 | 24156.94 | 27764.45 | 102.7590115 | -| S3c | 17246125 | 0.4636422 | 52687996543 | 3055.063 | 1497.584 | 2219.697 | 193660757 | 11.22923 | 13.67761 | 12.54244 | 70.85627 | 0.0029324 | 24162.85 | 29944.51 | 75.7744704 | -| S3d | 17255729 | 0.4639004 | 52823751959 | 3061.230 | 1497.584 | 2222.960 | 193728621 | 11.22692 | 13.67761 | 12.54073 | 74.11923 | 0.0012254 | 60484.25 | 56834.99 | \-12.8393196 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | --------: | ----------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 932813980 | 12.53975 | 0.00000 | 12.53975 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | +| S1a | 74386318 | 1.0000000 | 175298229824 | 2356.592 | 0.000 | 2356.592 | 933114770 | 12.54417 | 0.00000 | 12.54417 | 206.72538 | 0.0044259 | 46707.57 | 49922.89 | 14.572114 | +| S1b | 74385413 | 1.0000000 | 170952563916 | 2298.200 | 0.000 | 2298.200 | 932959012 | 12.54223 | 0.00000 | 12.54223 | 148.33311 | 0.0024846 | 59700.15 | 67733.79 | \-24.101345 | +| S1c | 74390720 | 1.0000000 | 171904343832 | 2310.830 | 0.000 | 2310.830 | 932972380 | 12.54152 | 0.00000 | 12.54152 | 160.96350 | 0.0017696 | 90961.23 | 109908.25 | \-72.484321 | +| S2NoCD | 44157029 | 0.5935995 | 117807957835 | 2667.932 | 1393.167 | 2149.867 | 541507456 | 12.26322 | 12.94364 | 12.53975 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | +| S2a | 44154576 | 0.5935665 | 124844786047 | 2827.448 | 1393.167 | 2244.508 | 541668368 | 12.26755 | 12.94364 | 12.54234 | 94.64148 | 0.0025899 | 36541.87 | 36877.58 | 34.855825 | +| S3NoCD | 34491937 | 0.4636724 | 99999943602 | 2899.227 | 1502.021 | 2149.867 | 387141750 | 11.22412 | 13.67714 | 12.53975 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | +| S3a | 34494037 | 0.4637007 | 104115381916 | 3018.359 | 1502.021 | 2205.148 | 387255177 | 11.22673 | 13.67714 | 12.54088 | 55.28112 | 0.0011387 | 48548.63 | 45732.73 | 1.652635 | +| S3b | 34509196 | 0.4639044 | 107308147373 | 3109.552 | 1502.021 | 2247.762 | 387545996 | 11.23022 | 13.67714 | 12.54201 | 97.89513 | 0.0022610 | 43297.43 | 34475.91 | 15.154445 | +| S3c | 34504471 | 0.4638409 | 105270593424 | 3050.926 | 1502.021 | 2220.467 | 387439707 | 11.22868 | 13.67714 | 12.54145 | 70.59986 | 0.0017009 | 41507.60 | 33281.70 | 14.444633 | +| S3d | 34501231 | 0.4637974 | 105602366018 | 3060.829 | 1502.021 | 2224.992 | 387400040 | 11.22859 | 13.67714 | 12.54151 | 75.12527 | 0.0017634 | 42603.53 | 36210.96 | 13.042632 | ![](../../outputs/Sen4_01_Treat_Util_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277801 | 0.1541410 | 0.2732173 | 0.0911566 | 0.4030472 | 0.0760263 | 0.1284096 | 0.0111267 | 0.8424613 | 0.0461119 | 0.0491189 | 0.0110335 | 0.0019273 | 0.3999881 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240553 | 0.1447802 | 0.2157515 | 0.0856247 | 0.4086320 | 0.0767122 | 0.1293709 | 0.0112159 | 0.8424572 | 0.0461045 | 0.0491178 | 0.0110465 | 0.0019286 | 0.2945268 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229349 | 0.1422163 | 0.1962587 | 0.0839634 | 0.4092320 | 0.0769957 | 0.1299784 | 0.0112125 | 0.8424873 | 0.0461079 | 0.0491353 | 0.0110154 | 0.0019116 | 0.2602946 | -| S2NoCD | 0.5934433 | 0.5822732 | 0.7055457 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935356 | 0.5822958 | 0.7060348 | 0.0214261 | 0.1433997 | 0.2089133 | 0.0847853 | 0.4076552 | 0.0767471 | 0.1292182 | 0.0111992 | 0.8425444 | 0.0460948 | 0.0491128 | 0.0109898 | 0.0019109 | 0.2776121 | -| S3NoCD | 0.4638687 | 0.4156354 | 0.5870736 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4637896 | 0.4156229 | 0.5868096 | 0.0197697 | 0.1380286 | 0.1714296 | 0.0812364 | 0.4112879 | 0.0772285 | 0.1300383 | 0.0112027 | 0.8426261 | 0.0461014 | 0.0490230 | 0.0109954 | 0.0019093 | 0.2168391 | -| S3b | 0.4636624 | 0.4156278 | 0.5873096 | 0.0217273 | 0.1440757 | 0.2123156 | 0.0853238 | 0.4076544 | 0.0766218 | 0.1293406 | 0.0111731 | 0.8425735 | 0.0461000 | 0.0490636 | 0.0110097 | 0.0019108 | 0.2840923 | -| S3c | 0.4636422 | 0.4155696 | 0.5876213 | 0.0206711 | 0.1409315 | 0.1917630 | 0.0832429 | 0.4099172 | 0.0770213 | 0.1297097 | 0.0111987 | 0.8425381 | 0.0460824 | 0.0491061 | 0.0110204 | 0.0019145 | 0.2493205 | -| S3d | 0.4639004 | 0.4157123 | 0.5874098 | 0.0202417 | 0.1395900 | 0.1822885 | 0.0822922 | 0.4104446 | 0.0770251 | 0.1298089 | 0.0112098 | 0.8425700 | 0.0461324 | 0.0490486 | 0.0110024 | 0.0019036 | 0.2342313 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277770 | 0.1541676 | 0.2735725 | 0.0911068 | 0.4036872 | 0.0760433 | 0.1284919 | 0.0111234 | 0.8424045 | 0.0461250 | 0.0491350 | 0.0110626 | 0.0019277 | 0.4003768 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240246 | 0.1449184 | 0.2159908 | 0.0856256 | 0.4082615 | 0.0767149 | 0.1294255 | 0.0111919 | 0.8424441 | 0.0461406 | 0.0491198 | 0.0110327 | 0.0019206 | 0.2943838 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229387 | 0.1419011 | 0.1959119 | 0.0838224 | 0.4094144 | 0.0768280 | 0.1296761 | 0.0111991 | 0.8425663 | 0.0460770 | 0.0490825 | 0.0110176 | 0.0019137 | 0.2600889 | +| S2NoCD | 0.5935995 | 0.5823361 | 0.7054688 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5935665 | 0.5824146 | 0.7059463 | 0.0213966 | 0.1438505 | 0.2094804 | 0.0850851 | 0.4086675 | 0.0767385 | 0.1294165 | 0.0112173 | 0.8425126 | 0.0461064 | 0.0490974 | 0.0110198 | 0.0019173 | 0.2779271 | +| S3NoCD | 0.4636724 | 0.4154340 | 0.5860893 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4637007 | 0.4155277 | 0.5865311 | 0.0197899 | 0.1383033 | 0.1717111 | 0.0814794 | 0.4121234 | 0.0772548 | 0.1301283 | 0.0112118 | 0.8425199 | 0.0460735 | 0.0491517 | 0.0110056 | 0.0019051 | 0.2173159 | +| S3b | 0.4639044 | 0.4157857 | 0.5876752 | 0.0217416 | 0.1441790 | 0.2124183 | 0.0853294 | 0.4094186 | 0.0768062 | 0.1294332 | 0.0111818 | 0.8424143 | 0.0460965 | 0.0491883 | 0.0110409 | 0.0019176 | 0.2844185 | +| S3c | 0.4638409 | 0.4156951 | 0.5869250 | 0.0206754 | 0.1410634 | 0.1917068 | 0.0833411 | 0.4105793 | 0.0769845 | 0.1297108 | 0.0112077 | 0.8424894 | 0.0460833 | 0.0491418 | 0.0110239 | 0.0019170 | 0.2496308 | +| S3d | 0.4637974 | 0.4156677 | 0.5868810 | 0.0202585 | 0.1397122 | 0.1824904 | 0.0824625 | 0.4112144 | 0.0771280 | 0.1298555 | 0.0112228 | 0.8424917 | 0.0460937 | 0.0491366 | 0.0110229 | 0.0019114 | 0.2345851 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 16.41272 hours + ## Time difference of 1.415365 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util3yrs.md index 510fe0e..e2e1ea2 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 0 Treatment Utility ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | -| S1NoCD | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466323094 | 12.537 | 624690.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466382779 | 12.538 | 624748.1 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466352936 | 12.537 | 624719.3 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195779 | 626218800 | 71281372 | 186100281 | 33119195 | 13388772 | 0.026 | 0.159 | 0.310 | 0.094 | 14905588 | 2814123 | 4756454 | 412031 | 0.209 | 0.039 | 0.067 | 0.006 | 527524487 | 28873365 | 30786968 | 6925999 | 1208772 | 90753454326 | 2439.886 | 466511424 | 12.542 | 624662.8 | 292.777 | 0.005 | 55225.17 | \-27.701 | -| S1b | 37200476 | 626144172 | 71252445 | 188422793 | 23802097 | 13372758 | 0.022 | 0.148 | 0.240 | 0.088 | 15103031 | 2841048 | 4796549 | 415612 | 0.212 | 0.040 | 0.067 | 0.006 | 527481440 | 28877807 | 30767692 | 6915814 | 1204950 | 87878153022 | 2362.286 | 466458269 | 12.539 | 624589.7 | 215.177 | 0.002 | 94003.09 | \-100.725 | -| S1c | 37192813 | 625960445 | 71159107 | 189176712 | 20537777 | 13372239 | 0.020 | 0.144 | 0.214 | 0.085 | 15172732 | 2850944 | 4816068 | 416845 | 0.213 | 0.040 | 0.068 | 0.006 | 527395566 | 28830750 | 30734973 | 6903078 | 1206962 | 88797560537 | 2387.492 | 466325356 | 12.538 | 624515.0 | 240.384 | 0.001 | 185067.55 | \-175.439 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | +| S1NoCD | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 932633078 | 12.537 | 624716.3 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 932675718 | 12.538 | 624744.0 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 932654398 | 12.538 | 624730.2 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74380275 | 1252107231 | 142568770 | 372100831 | 66270673 | 26745802 | 0.026 | 0.159 | 0.310 | 0.094 | 29815042 | 5625494 | 9500837 | 824680.0 | 0.209 | 0.039 | 0.067 | 0.006 | 1054730269 | 57758498 | 61574433 | 13835312 | 2423951 | 181401075128 | 2438.833 | 932778303 | 12.541 | 624594.5 | 290.796 | 0.003 | 86022.11 | \-121.772 | +| S1b | 74383024 | 1252030978 | 142410670 | 376764647 | 47607118 | 26748888 | 0.022 | 0.148 | 0.241 | 0.088 | 30192660 | 5683507 | 9596337 | 830158.0 | 0.212 | 0.040 | 0.067 | 0.006 | 1054810413 | 57710159 | 61499603 | 13827904 | 2405886 | 175747140584 | 2362.732 | 932727596 | 12.540 | 624613.4 | 214.694 | 0.002 | 96047.29 | \-102.929 | +| S1c | 74393892 | 1252166867 | 142379318 | 378416895 | 41063274 | 26758496 | 0.020 | 0.144 | 0.214 | 0.085 | 30350312 | 5702044 | 9621386 | 828456.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054965444 | 57726777 | 61483651 | 13803995 | 2400849 | 177409072797 | 2384.726 | 932831880 | 12.539 | 624569.9 | 236.689 | 0.002 | 131113.56 | \-146.428 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22078563 | 364522749 | 50166624 | 110968095 | 9653606 | 7738507 | 0.017 | 0.141 | 0.159 | 0.087 | 11438971 | 2125413 | 3543389 | 304919 | 0.228 | 0.042 | 0.071 | 0.006 | 298790021 | 18633807 | 22502661 | 5543543 | 1025792 | 58731887921 | 2660.132 | 270698655 | 12.261 | 610374.9 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077788 | 364622606 | 50226923 | 108797477 | 18511084 | 7734136 | 0.023 | 0.157 | 0.269 | 0.097 | 11192847 | 2087413 | 3500787 | 300763 | 0.223 | 0.042 | 0.070 | 0.006 | 298828425 | 18622586 | 22524521 | 5579724 | 1036307 | 63840415723 | 2891.613 | 270769119 | 12.264 | 610324.5 | 231.481 | 0.004 | 63908.96 | \-50.379 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44156404 | 729084497 | 100330760 | 221928932 | 19330952 | 15481473 | 0.017 | 0.142 | 0.159 | 0.087 | 22917076 | 4253860 | 7098458 | 609501 | 0.228 | 0.042 | 0.071 | 0.006 | 597619551 | 37246010 | 44990133 | 11123560 | 2050468 | 117605933755 | 2663.395 | 541420336 | 12.261 | 610407.7 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44164773 | 729329891 | 100492049 | 217625447 | 37010683 | 15485858 | 0.023 | 0.157 | 0.269 | 0.097 | 22383331 | 4181008 | 7006346 | 603148 | 0.223 | 0.042 | 0.070 | 0.006 | 597700094 | 37284225 | 45068617 | 11147317 | 2064302 | 127735308298 | 2892.244 | 541606918 | 12.263 | 610274.0 | 228.849 | 0.002 | 120370.9 | \-133.789 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | -| S3NoCD | 17243525 | 260017880 | 41691838 | 80059027 | 7819384 | 5815322 | 0.018 | 0.137 | 0.154 | 0.086 | 9754415 | 1816466 | 3038101 | 261338 | 0.234 | 0.044 | 0.073 | 0.006 | 207433146 | 15294590 | 18682841 | 4808648 | 895345 | 49933527334 | 2895.784 | 193498381 | 11.222 | 558179.7 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17245589 | 260114351 | 41778508 | 79305268 | 11012874 | 5816924 | 0.021 | 0.144 | 0.204 | 0.091 | 9648241 | 1803612 | 3027939 | 260144 | 0.231 | 0.043 | 0.072 | 0.006 | 207442211 | 15303706 | 18733677 | 4824249 | 900624 | 53097071421 | 3078.878 | 193562097 | 11.224 | 558114.2 | 183.094 | 0.002 | 77859.18 | \-65.514 | -| S3b | 17248093 | 260143539 | 41765340 | 77789956 | 17179218 | 5809490 | 0.027 | 0.156 | 0.293 | 0.099 | 9481831 | 1779958 | 2992091 | 258625 | 0.227 | 0.043 | 0.072 | 0.006 | 207483725 | 15287322 | 18724587 | 4837601 | 899769 | 55163743515 | 3198.252 | 193591882 | 11.224 | 557999.7 | 302.468 | 0.002 | 123506.72 | \-180.018 | -| S3c | 17249568 | 260123652 | 41796963 | 78552778 | 14093542 | 5811921 | 0.024 | 0.150 | 0.249 | 0.095 | 9556493 | 1794042 | 3007246 | 258985 | 0.229 | 0.043 | 0.072 | 0.006 | 207434647 | 15324709 | 18727689 | 4823824 | 902793 | 53820717606 | 3120.120 | 193574318 | 11.222 | 557978.9 | 224.336 | 0.000 | 476269.83 | \-200.784 | -| S3d | 17250373 | 260166499 | 41788451 | 78909896 | 12694599 | 5812281 | 0.023 | 0.147 | 0.229 | 0.093 | 9596955 | 1798651 | 3013620 | 260246 | 0.230 | 0.043 | 0.072 | 0.006 | 207483596 | 15310784 | 18731510 | 4829309 | 900292 | 54140141633 | 3138.491 | 193605072 | 11.223 | 558023.5 | 242.707 | 0.002 | 140281.57 | \-156.200 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | +| S3NoCD | 34500334 | 520264617 | 83469550 | 160191877 | 15617539 | 11630123 | 0.018 | 0.137 | 0.154 | 0.086 | 19525292 | 3631989 | 6073558 | 522424 | 0.234 | 0.044 | 0.073 | 0.006 | 415002016 | 30608834 | 37422882 | 9624470 | 1788687 | 99842281258 | 2893.951 | 387162460 | 11.222 | 558205.6 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34507415 | 520428951 | 83482576 | 158676520 | 22030098 | 11639538 | 0.021 | 0.144 | 0.204 | 0.091 | 19287934 | 3609226 | 6045313 | 521405 | 0.231 | 0.043 | 0.072 | 0.006 | 415152628 | 30610103 | 37407716 | 9641236 | 1794702 | 106095806862 | 3074.580 | 387293058 | 11.223 | 558099.1 | 180.629 | 0.001 | 121892.18 | \-106.535 | +| S3b | 34499539 | 520396932 | 83618002 | 155590263 | 34428826 | 11625591 | 0.027 | 0.156 | 0.293 | 0.099 | 18988453 | 3564625 | 5980823 | 516662 | 0.227 | 0.043 | 0.072 | 0.006 | 414988556 | 30607762 | 37472866 | 9688489 | 1813970 | 110363699543 | 3198.991 | 387254557 | 11.225 | 558047.0 | 305.039 | 0.003 | 104176.20 | \-158.634 | +| S3c | 34496334 | 520227370 | 83568351 | 157099275 | 28171361 | 11622564 | 0.024 | 0.150 | 0.249 | 0.095 | 19145218 | 3585036 | 6010150 | 518449 | 0.229 | 0.043 | 0.072 | 0.006 | 414875686 | 30589301 | 37479876 | 9661353 | 1804425 | 107627143927 | 3119.959 | 387132897 | 11.222 | 558001.8 | 226.008 | 0.000 | 508728.90 | \-203.795 | +| S3d | 34507664 | 520495018 | 83555471 | 157877292 | 25364366 | 11630839 | 0.023 | 0.147 | 0.229 | 0.093 | 19209915 | 3595849 | 6028084 | 520340 | 0.230 | 0.043 | 0.072 | 0.006 | 415141325 | 30594930 | 37472224 | 9653084 | 1805226 | 108255487965 | 3137.143 | 387331029 | 11.224 | 558087.5 | 243.192 | 0.003 | 97228.27 | \-118.130 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | --------: | -------------: | -| S1NoCD | 37196486 | 79864892645 | 2147.109 | 466323094 | 12.537 | NaN | 0.000 | -| S2NoCD | 22078563 | 58731887921 | 2660.132 | 270698655 | 12.261 | NaN | 0.000 | -| S3NoCD | 17243525 | 49933527334 | 2895.784 | 193498381 | 11.222 | NaN | 0.000 | -| S1a | 37195779 | 90753454326 | 2439.886 | 466511424 | 12.542 | 55225.17 | \-27.701 | -| S2a | 22077788 | 63840415723 | 2891.613 | 270769119 | 12.264 | 63908.96 | \-50.379 | -| S3a | 17245589 | 53097071421 | 3078.878 | 193562097 | 11.224 | 77859.18 | \-65.514 | -| S1b | 37200476 | 87878153022 | 2362.286 | 466458269 | 12.539 | 94003.09 | \-100.725 | -| S3d | 17250373 | 54140141633 | 3138.491 | 193605072 | 11.223 | 140281.57 | \-156.200 | -| S1c | 37192813 | 88797560537 | 2387.492 | 466325356 | 12.538 | 185067.55 | \-175.439 | -| S3b | 17248093 | 55163743515 | 3198.252 | 193591882 | 11.224 | 123506.72 | \-180.018 | -| S3c | 17249568 | 53820717606 | 3120.120 | 193574318 | 11.222 | 476269.83 | \-200.784 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | --------: | -------------: | +| S1NoCD | 74388747 | 159789813678 | 2148.037 | 932633078 | 12.537 | NaN | 0.000 | +| S2NoCD | 44156404 | 117605933755 | 2663.395 | 541420336 | 12.261 | NaN | 0.000 | +| S3NoCD | 34500334 | 99842281258 | 2893.951 | 387162460 | 11.222 | NaN | 0.000 | +| S1b | 74383024 | 175747140584 | 2362.732 | 932727596 | 12.540 | 96047.29 | \-102.929 | +| S3a | 34507415 | 106095806862 | 3074.580 | 387293058 | 11.223 | 121892.18 | \-106.535 | +| S3d | 34507664 | 108255487965 | 3137.143 | 387331029 | 11.224 | 97228.27 | \-118.130 | +| S1a | 74380275 | 181401075128 | 2438.833 | 932778303 | 12.541 | 86022.11 | \-121.772 | +| S2a | 44164773 | 127735308298 | 2892.244 | 541606918 | 12.263 | 120370.87 | \-133.789 | +| S1c | 74393892 | 177409072797 | 2384.726 | 932831880 | 12.539 | 131113.56 | \-146.428 | +| S3b | 34499539 | 110363699543 | 3198.991 | 387254557 | 11.225 | 104176.20 | \-158.634 | +| S3c | 34496334 | 107627143927 | 3119.959 | 387132897 | 11.222 | 508728.90 | \-203.795 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | ----------: | --------: | ------------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466352936 | 12.53736 | 0.00000 | 12.53736 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37195779 | 1.0000000 | 90753454326 | 2439.886 | 0.000 | 2439.886 | 466511424 | 12.54205 | 0.00000 | 12.54205 | 291.04522 | 0.0046908 | 62045.48 | 55225.17 | \-56.5033623 | -| S1b | 37200476 | 1.0000000 | 87878153022 | 2362.286 | 0.000 | 2362.286 | 466458269 | 12.53904 | 0.00000 | 12.53904 | 213.44510 | 0.0016784 | 127174.65 | 94003.09 | \-129.5269999 | -| S1c | 37192813 | 1.0000000 | 88797560537 | 2387.492 | 0.000 | 2387.492 | 466325356 | 12.53805 | 0.00000 | 12.53805 | 238.65184 | 0.0006882 | 346768.56 | 185067.56 | \-204.2410186 | -| S2NoCD | 22078563 | 0.5935568 | 58731887921 | 2660.132 | 1402.167 | 2148.841 | 270698655 | 12.26070 | 12.94139 | 12.53736 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083974 | -| S2a | 22077788 | 0.5935359 | 63840415723 | 2891.613 | 1402.167 | 2286.207 | 270769119 | 12.26432 | 12.94139 | 12.53953 | 137.36611 | 0.0021640 | 63478.01 | 63908.96 | \-29.1579448 | -| S3NoCD | 17243525 | 0.4635723 | 49933527334 | 2895.784 | 1503.344 | 2148.841 | 193498381 | 11.22151 | 13.67450 | 12.53736 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083974 | -| S3a | 17245589 | 0.4636278 | 53097071421 | 3078.878 | 1503.344 | 2233.805 | 193562097 | 11.22386 | 13.67450 | 12.53832 | 84.96483 | 0.0009542 | 89046.90 | 77859.18 | \-37.2485208 | -| S3b | 17248093 | 0.4636951 | 55163743515 | 3198.252 | 1503.344 | 2289.264 | 193591882 | 11.22396 | 13.67450 | 12.53820 | 140.42373 | 0.0008343 | 168303.72 | 123506.72 | \-98.6979716 | -| S3c | 17249568 | 0.4637348 | 53820717606 | 3120.120 | 1503.344 | 2253.099 | 193574318 | 11.22198 | 13.67450 | 12.53718 | 104.25841 | \-0.0001801 | \-578957.34 | 476269.83 | \-113.2539887 | -| S3d | 17250373 | 0.4637564 | 54140141633 | 3138.491 | 1503.344 | 2261.654 | 193605072 | 11.22324 | 13.67450 | 12.53771 | 112.81322 | 0.0003508 | 321618.97 | 140281.57 | \-95.2664877 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | --------: | --------: | ----------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 932654398 | 12.53760 | 0.00000 | 12.53760 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74380275 | 1.0000000 | 181401075128 | 2438.833 | 0.000 | 2438.833 | 932778303 | 12.54067 | 0.00000 | 12.54067 | 288.96609 | 0.0030667 | 94225.75 | 86022.11 | \-135.62898 | +| S1b | 74383024 | 1.0000000 | 175747140584 | 2362.732 | 0.000 | 2362.732 | 932727596 | 12.53952 | 0.00000 | 12.53952 | 212.86487 | 0.0019216 | 110776.78 | 96047.29 | \-116.78658 | +| S1c | 74393892 | 1.0000000 | 177409072797 | 2384.726 | 0.000 | 2384.726 | 932831880 | 12.53909 | 0.00000 | 12.53909 | 234.85933 | 0.0014915 | 157466.56 | 131113.56 | \-160.28498 | +| S2NoCD | 44156404 | 0.5935911 | 117605933755 | 2663.395 | 1399.821 | 2149.867 | 541420336 | 12.26142 | 12.94098 | 12.53760 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44164773 | 0.5937036 | 127735308298 | 2892.244 | 1399.821 | 2285.878 | 541606918 | 12.26332 | 12.94098 | 12.53865 | 136.01091 | 0.0010523 | 129251.28 | 120370.87 | \-83.39599 | +| S3NoCD | 34500334 | 0.4637853 | 99842281258 | 2893.951 | 1506.290 | 2149.867 | 387162460 | 11.22199 | 13.67550 | 12.53760 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34507415 | 0.4638805 | 106095806862 | 3074.580 | 1506.290 | 2233.789 | 387293058 | 11.22347 | 13.67550 | 12.53805 | 83.92228 | 0.0004539 | 184906.15 | 121892.18 | \-61.22907 | +| S3b | 34499539 | 0.4637746 | 110363699543 | 3198.991 | 1506.290 | 2291.322 | 387254557 | 11.22492 | 13.67550 | 12.53899 | 141.45471 | 0.0013842 | 102192.07 | 104176.20 | \-72.24449 | +| S3c | 34496334 | 0.4637315 | 107627143927 | 3119.959 | 1506.290 | 2254.599 | 387132897 | 11.22244 | 13.67550 | 12.53794 | 104.73230 | 0.0003379 | 309907.73 | 508728.90 | \-87.83497 | +| S3d | 34507664 | 0.4638839 | 108255487965 | 3137.143 | 1506.290 | 2262.817 | 387331029 | 11.22449 | 13.67550 | 12.53852 | 112.94966 | 0.0009185 | 122968.04 | 97228.27 | \-67.02323 | ![](../../outputs/Sen5_0_Treat_Util_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264130 | 0.1594355 | 0.3100498 | 0.0943012 | 0.4007333 | 0.0756571 | 0.1278762 | 0.0110774 | 0.8423964 | 0.0461075 | 0.0491633 | 0.0110600 | 0.0019303 | 0.4646262 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216055 | 0.1480604 | 0.2404960 | 0.0875941 | 0.4059903 | 0.0763713 | 0.1289378 | 0.0111722 | 0.8424281 | 0.0461201 | 0.0491384 | 0.0110451 | 0.0019244 | 0.3340531 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201493 | 0.1442413 | 0.2143855 | 0.0852093 | 0.4079480 | 0.0766531 | 0.1294892 | 0.0112077 | 0.8425382 | 0.0460584 | 0.0491005 | 0.0110280 | 0.0019282 | 0.2886177 | -| S2NoCD | 0.5935568 | 0.5823097 | 0.7053578 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935359 | 0.5824692 | 0.7062056 | 0.0223351 | 0.1468614 | 0.2290467 | 0.0868672 | 0.4071715 | 0.0764348 | 0.1292457 | 0.0111517 | 0.8425215 | 0.0460676 | 0.0490957 | 0.0110473 | 0.0019254 | 0.3104013 | -| S3NoCD | 0.4635723 | 0.4153676 | 0.5861997 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4636278 | 0.4155217 | 0.5874183 | 0.0201358 | 0.1392626 | 0.1805149 | 0.0822287 | 0.4109128 | 0.0771069 | 0.1301110 | 0.0112307 | 0.8424794 | 0.0461006 | 0.0491419 | 0.0110143 | 0.0019170 | 0.2306846 | -| S3b | 0.4636951 | 0.4155683 | 0.5872332 | 0.0226883 | 0.1466743 | 0.2326983 | 0.0870001 | 0.4064201 | 0.0764674 | 0.1291411 | 0.0111894 | 0.8425049 | 0.0460727 | 0.0491259 | 0.0110354 | 0.0019156 | 0.3174192 | -| S3c | 0.4637348 | 0.4155365 | 0.5876778 | 0.0213351 | 0.1429510 | 0.2072023 | 0.0845726 | 0.4084161 | 0.0768439 | 0.1295450 | 0.0111987 | 0.8424543 | 0.0461336 | 0.0491319 | 0.0110136 | 0.0019205 | 0.2739520 | -| S3d | 0.4637564 | 0.4156050 | 0.5875581 | 0.0207664 | 0.1413812 | 0.1952106 | 0.0835996 | 0.4094977 | 0.0769666 | 0.1297144 | 0.0112325 | 0.8424726 | 0.0461088 | 0.0491357 | 0.0110219 | 0.0019164 | 0.2543044 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264033 | 0.1593018 | 0.3099946 | 0.0940914 | 0.4008461 | 0.0756315 | 0.1277333 | 0.0110873 | 0.8423642 | 0.0461290 | 0.0491766 | 0.0110496 | 0.0019359 | 0.4648330 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216398 | 0.1482342 | 0.2406521 | 0.0877947 | 0.4059079 | 0.0764087 | 0.1290125 | 0.0111606 | 0.8424795 | 0.0460932 | 0.0491199 | 0.0110444 | 0.0019216 | 0.3342946 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201517 | 0.1441110 | 0.2141912 | 0.0851720 | 0.4079678 | 0.0766467 | 0.1293303 | 0.0111361 | 0.8425119 | 0.0461015 | 0.0491018 | 0.0110241 | 0.0019174 | 0.2884076 | +| S2NoCD | 0.5935911 | 0.5823656 | 0.7051165 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5937036 | 0.5825616 | 0.7062500 | 0.0223572 | 0.1465203 | 0.2287835 | 0.0867962 | 0.4069072 | 0.0764858 | 0.1291620 | 0.0111850 | 0.8424534 | 0.0460995 | 0.0491621 | 0.0110233 | 0.0019191 | 0.3102030 | +| S3NoCD | 0.4637853 | 0.4155681 | 0.5866172 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4638805 | 0.4156993 | 0.5867088 | 0.0201156 | 0.1395918 | 0.1808230 | 0.0824771 | 0.4108939 | 0.0771596 | 0.1300215 | 0.0112568 | 0.8425660 | 0.0460728 | 0.0490892 | 0.0110179 | 0.0019129 | 0.2311946 | +| S3b | 0.4637746 | 0.4156737 | 0.5876605 | 0.0227032 | 0.1471017 | 0.2332507 | 0.0873282 | 0.4068980 | 0.0765657 | 0.1291642 | 0.0111939 | 0.8424573 | 0.0460719 | 0.0491421 | 0.0110558 | 0.0019283 | 0.3181560 | +| S3c | 0.4637315 | 0.4155383 | 0.5873116 | 0.0213262 | 0.1432680 | 0.2074859 | 0.0848645 | 0.4090175 | 0.0768424 | 0.1295624 | 0.0112182 | 0.8424856 | 0.0460621 | 0.0491521 | 0.0110349 | 0.0019208 | 0.2742435 | +| S3d | 0.4638839 | 0.4157521 | 0.5872211 | 0.0207546 | 0.1415673 | 0.1954816 | 0.0837051 | 0.4098442 | 0.0769796 | 0.1297896 | 0.0112424 | 0.8425108 | 0.0460587 | 0.0491390 | 0.0110271 | 0.0019212 | 0.2545329 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 17.25901 hours + ## Time difference of 1.45615 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util5yrs.md index 52746ff..95fc814 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen5_0_Treat_Util5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 0 Treatment Utility ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | -| S1NoCD2 | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 79864892645 | 2147.109 | 466323094 | 12.537 | 624690.5 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 79996190237 | 2150.573 | 466382779 | 12.538 | 624748.1 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 79930541441 | 2148.841 | 466352936 | 12.537 | 624719.3 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37197502 | 626089853 | 71222084 | 122776626 | 28487983 | 16327137 | 0.028 | 0.154 | 0.273 | 0.091 | 14992350 | 2827989 | 4776515 | 413886 | 0.211 | 0.040 | 0.067 | 0.006 | 527456443 | 28870190 | 30752817 | 6907934 | 1206659 | 87609315426 | 2355.247 | 466423279 | 12.539 | 624599.9 | 204.675 | 0.001 | 181198.47 | \-148.197 | -| S1b | 37190655 | 625992698 | 71214502 | 123717512 | 20974578 | 16327973 | 0.024 | 0.145 | 0.216 | 0.086 | 15197291 | 2852978 | 4811387 | 417126 | 0.213 | 0.040 | 0.068 | 0.006 | 527372066 | 28861102 | 30747408 | 6915037 | 1207305 | 85474784067 | 2298.287 | 466341309 | 12.539 | 624662.0 | 147.714 | 0.001 | 119700.89 | \-86.013 | -| S1c | 37195162 | 626110982 | 71210037 | 124047387 | 18535585 | 16324587 | 0.023 | 0.142 | 0.196 | 0.084 | 15221449 | 2863867 | 4834566 | 417049 | 0.214 | 0.040 | 0.068 | 0.006 | 527490541 | 28868640 | 30764128 | 6896850 | 1196858 | 86086185363 | 2314.446 | 466430966 | 12.540 | 624690.4 | 163.873 | 0.002 | 77113.78 | \-57.619 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD2 | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 159789813678 | 2148.037 | 932633078 | 12.537 | 624716.3 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 160061317736 | 2151.697 | 932675718 | 12.538 | 624744.0 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 159925565707 | 2149.867 | 932654398 | 12.538 | 624730.2 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386318 | 1252092577 | 142511621 | 245523949 | 57058349 | 32655914 | 0.028 | 0.154 | 0.274 | 0.091 | 30028808 | 5656584 | 9558038 | 827432.0 | 0.211 | 0.040 | 0.067 | 0.006 | 1054768469 | 57752767 | 61521629 | 13851433 | 2413714 | 175298229824 | 2356.592 | 932770789 | 12.540 | 624620.8 | 204.896 | 0.002 | 125455.6 | \-123.235 | +| S1b | 74385413 | 1252007176 | 142455061 | 247448362 | 41936466 | 32651747 | 0.024 | 0.145 | 0.216 | 0.086 | 30368698 | 5706469 | 9627370 | 832514.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054746061 | 57768304 | 61498391 | 13812986 | 2404656 | 170952563916 | 2298.200 | 932704901 | 12.539 | 624642.5 | 146.504 | 0.001 | 162779.0 | \-101.503 | +| S1c | 74390720 | 1252048091 | 142295860 | 248074520 | 37009576 | 32668233 | 0.023 | 0.142 | 0.196 | 0.084 | 30456632 | 5715293 | 9646702 | 833108.0 | 0.214 | 0.040 | 0.068 | 0.006 | 1054933501 | 57690667 | 61453687 | 13794504 | 2396041 | 171904343832 | 2310.830 | 932748272 | 12.539 | 624614.3 | 159.134 | 0.001 | 270403.2 | \-129.709 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ---------: | -------------: | -| S2NoCD | 22074342 | 364499893 | 50179989 | 72492409 | 9769650 | 9434235 | 0.021 | 0.142 | 0.160 | 0.087 | 11472370 | 2126666 | 3551252 | 304704 | 0.229 | 0.042 | 0.071 | 0.006 | 298757005 | 18626945 | 22501053 | 5562438 | 1027303 | 58922537505 | 2669.277 | 270674278 | 12.262 | 610427.8 | 0.0 | 0.000 | NaN | 0.000 | -| S2a | 22077777 | 364514086 | 50214779 | 71673455 | 16290550 | 9435494 | 0.025 | 0.153 | 0.241 | 0.095 | 11245330 | 2100490 | 3507989 | 302346 | 0.224 | 0.042 | 0.070 | 0.006 | 298734836 | 18629376 | 22530917 | 5562183 | 1028646 | 62347138314 | 2823.977 | 270692612 | 12.261 | 610219.2 | 154.7 | \-0.001 | \-143592.4 | \-208.568 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44157029 | 729047563 | 100380900 | 145000421 | 19524492 | 18863743 | 0.021 | 0.142 | 0.160 | 0.087 | 22925265 | 4254784 | 7099566 | 609563 | 0.228 | 0.042 | 0.071 | 0.006 | 597538799 | 37245010 | 45040554 | 11117169 | 2054803 | 117807957835 | 2667.932 | 541387059 | 12.260 | 610356.8 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44154576 | 729145856 | 100448839 | 143361789 | 32595478 | 18878233 | 0.025 | 0.154 | 0.242 | 0.095 | 22519648 | 4200194 | 7025459 | 605531 | 0.224 | 0.042 | 0.070 | 0.006 | 597564735 | 37286040 | 45033303 | 11135908 | 2066352 | 124844786047 | 2827.448 | 541466014 | 12.263 | 610320.8 | 159.516 | 0.002 | 64600.18 | \-36.052 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | --------: | -------------: | -| S3NoCD | 17254548 | 260185517 | 41753987 | 52456874 | 7922835 | 7061036 | 0.022 | 0.137 | 0.155 | 0.086 | 9767617 | 1818208 | 3040076 | 262205 | 0.234 | 0.044 | 0.073 | 0.006 | 207533583 | 15301679 | 18724752 | 4815426 | 897482 | 50064966233 | 2901.552 | 193618019 | 11.221 | 558162.2 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17251608 | 260177738 | 41735217 | 52193377 | 10112286 | 7056308 | 0.024 | 0.142 | 0.189 | 0.089 | 9673981 | 1809610 | 3026757 | 259927 | 0.232 | 0.043 | 0.073 | 0.006 | 207543323 | 15307443 | 18697708 | 4818609 | 897810 | 52066304895 | 3018.055 | 193617330 | 11.223 | 558139.3 | 116.503 | 0.002 | 62221.96 | \-22.884 | -| S3b | 17246874 | 260180750 | 41770771 | 51592135 | 14901907 | 7060341 | 0.029 | 0.152 | 0.258 | 0.096 | 9537491 | 1786791 | 3000373 | 258790 | 0.228 | 0.043 | 0.072 | 0.006 | 207513062 | 15306657 | 18723252 | 4827550 | 898750 | 53626126689 | 3109.324 | 193617261 | 11.226 | 558201.8 | 207.773 | 0.005 | 41983.02 | 39.676 | -| S3c | 17246125 | 260144350 | 41792942 | 51894923 | 12432863 | 7060467 | 0.026 | 0.147 | 0.223 | 0.093 | 9621451 | 1801612 | 3014035 | 259735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459068 | 15294280 | 18748666 | 4834049 | 901039 | 52687996543 | 3055.063 | 193583357 | 11.225 | 558182.2 | 153.511 | 0.003 | 44231.46 | 20.020 | -| S3d | 17255729 | 260233694 | 41777900 | 52047317 | 11356970 | 7062160 | 0.025 | 0.144 | 0.207 | 0.091 | 9643777 | 1802264 | 3018596 | 260225 | 0.231 | 0.043 | 0.072 | 0.006 | 207557193 | 15328896 | 18715546 | 4823282 | 894293 | 52823751959 | 3061.230 | 193658024 | 11.223 | 558080.0 | 159.678 | 0.002 | 102994.55 | \-82.160 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34491937 | 520096794 | 83394436 | 104866546 | 15798844 | 14116443 | 0.022 | 0.137 | 0.154 | 0.086 | 19479590 | 3630576 | 6075819 | 523166 | 0.234 | 0.044 | 0.073 | 0.006 | 414917152 | 30599570 | 37365292 | 9614469 | 1790750 | 99999943602 | 2899.227 | 387044339 | 11.221 | 558165.7 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34494037 | 520214111 | 83457293 | 104351592 | 20245608 | 14129448 | 0.024 | 0.142 | 0.189 | 0.089 | 19332282 | 3614629 | 6055063 | 518761 | 0.232 | 0.043 | 0.073 | 0.006 | 414968911 | 30599997 | 37426814 | 9615582 | 1787056 | 104115381916 | 3018.359 | 387129436 | 11.223 | 558135.8 | 119.132 | 0.002 | 66783.39 | \-29.939 | +| S3b | 34509196 | 520537138 | 83620081 | 103218767 | 29823148 | 14132996 | 0.029 | 0.152 | 0.258 | 0.096 | 19135380 | 3582069 | 6004729 | 516649 | 0.229 | 0.043 | 0.072 | 0.006 | 415119150 | 30640730 | 37483240 | 9661621 | 1802895 | 107308147373 | 3109.552 | 387360806 | 11.225 | 558133.3 | 210.326 | 0.004 | 59106.08 | \-32.403 | +| S3c | 34504471 | 520423616 | 83513343 | 103824096 | 24853847 | 14121585 | 0.026 | 0.146 | 0.223 | 0.093 | 19220385 | 3595075 | 6024956 | 518536 | 0.230 | 0.043 | 0.072 | 0.006 | 415113845 | 30619979 | 37421385 | 9639642 | 1802009 | 105270593424 | 3050.926 | 387285272 | 11.224 | 558159.3 | 151.699 | 0.003 | 52193.94 | \-6.377 | +| S3d | 34501231 | 520389346 | 83507084 | 104079260 | 22711874 | 14135933 | 0.025 | 0.144 | 0.207 | 0.091 | 19266710 | 3605577 | 6035420 | 519637 | 0.231 | 0.043 | 0.072 | 0.006 | 415086795 | 30631737 | 37413709 | 9638221 | 1794998 | 105602366018 | 3060.829 | 387258905 | 11.224 | 558163.9 | 161.602 | 0.003 | 50559.69 | \-1.789 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | ----------: | -------------: | -| S3b | 17246874 | 53626126689 | 3109.324 | 193617261 | 11.226 | 41983.02 | 39.676 | -| S3c | 17246125 | 52687996543 | 3055.063 | 193583357 | 11.225 | 44231.46 | 20.020 | -| S1NoCD | 37197623 | 79996190237 | 2150.573 | 466382779 | 12.538 | NaN | 0.000 | -| S2NoCD | 22074342 | 58922537505 | 2669.277 | 270674278 | 12.262 | NaN | 0.000 | -| S3NoCD | 17254548 | 50064966233 | 2901.552 | 193618019 | 11.221 | NaN | 0.000 | -| S3a | 17251608 | 52066304895 | 3018.055 | 193617330 | 11.223 | 62221.96 | \-22.884 | -| S1c | 37195162 | 86086185363 | 2314.446 | 466430966 | 12.540 | 77113.78 | \-57.619 | -| S3d | 17255729 | 52823751959 | 3061.230 | 193658024 | 11.223 | 102994.55 | \-82.160 | -| S1b | 37190655 | 85474784067 | 2298.287 | 466341309 | 12.539 | 119700.89 | \-86.013 | -| S1a | 37197502 | 87609315426 | 2355.247 | 466423279 | 12.539 | 181198.47 | \-148.197 | -| S2a | 22077777 | 62347138314 | 2823.977 | 270692612 | 12.261 | \-143592.40 | \-208.568 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | --------: | -------------: | +| S1NoCD | 74388425 | 160061317736 | 2151.697 | 932675718 | 12.538 | NaN | 0.000 | +| S2NoCD | 44157029 | 117807957835 | 2667.932 | 541387059 | 12.260 | NaN | 0.000 | +| S3NoCD | 34491937 | 99999943602 | 2899.227 | 387044339 | 11.221 | NaN | 0.000 | +| S3d | 34501231 | 105602366018 | 3060.829 | 387258905 | 11.224 | 50559.69 | \-1.789 | +| S3c | 34504471 | 105270593424 | 3050.926 | 387285272 | 11.224 | 52193.94 | \-6.377 | +| S3a | 34494037 | 104115381916 | 3018.359 | 387129436 | 11.223 | 66783.39 | \-29.939 | +| S3b | 34509196 | 107308147373 | 3109.552 | 387360806 | 11.225 | 59106.08 | \-32.403 | +| S2a | 44154576 | 124844786047 | 2827.448 | 541466014 | 12.263 | 64600.18 | \-36.052 | +| S1b | 74385413 | 170952563916 | 2298.200 | 932704901 | 12.539 | 162779.04 | \-101.503 | +| S1a | 74386318 | 175298229824 | 2356.592 | 932770789 | 12.540 | 125455.61 | \-123.235 | +| S1c | 74390720 | 171904343832 | 2310.830 | 932748272 | 12.539 | 270403.20 | \-129.709 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | ----------: | ----------: | ------------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 79930541441 | 2148.841 | 0.000 | 2148.841 | 466352936 | 12.53736 | 0.00000 | 12.53736 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37197502 | 1.0000000 | 87609315426 | 2355.247 | 0.000 | 2355.247 | 466423279 | 12.53910 | 0.00000 | 12.53910 | 206.40667 | 0.0017402 | 118609.28 | 181198.47 | \-119.3954868 | -| S1b | 37190655 | 1.0000000 | 85474784067 | 2298.287 | 0.000 | 2298.287 | 466341309 | 12.53921 | 0.00000 | 12.53921 | 149.44599 | 0.0018447 | 81014.20 | 119700.89 | \-57.2115521 | -| S1c | 37195162 | 1.0000000 | 86086185363 | 2314.446 | 0.000 | 2314.446 | 466430966 | 12.54010 | 0.00000 | 12.54010 | 165.60516 | 0.0027357 | 60533.83 | 77113.78 | \-28.8178814 | -| S2NoCD | 22074342 | 0.5934433 | 58922537505 | 2669.277 | 1389.169 | 2148.841 | 270674278 | 12.26194 | 12.93939 | 12.53736 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083974 | -| S2a | 22077777 | 0.5935356 | 62347138314 | 2823.977 | 1389.169 | 2240.779 | 270692612 | 12.26086 | 12.93939 | 12.53666 | 91.93817 | \-0.0007020 | \-130964.52 | \-143592.40 | \-127.0301828 | -| S3NoCD | 17254548 | 0.4638687 | 50064966233 | 2901.552 | 1497.584 | 2148.841 | 193618019 | 11.22127 | 13.67606 | 12.53736 | 0.00000 | 0.0000000 | NaN | NaN | 0.0083974 | -| S3a | 17251608 | 0.4637896 | 52066304895 | 3018.055 | 1497.584 | 2202.763 | 193617330 | 11.22315 | 13.67606 | 12.53842 | 53.92205 | 0.0010624 | 50754.27 | 62221.96 | \-0.7929502 | -| S3b | 17246874 | 0.4636624 | 53626126689 | 3109.324 | 1497.584 | 2244.887 | 193617261 | 11.22622 | 13.67606 | 12.54016 | 96.04666 | 0.0028011 | 34289.05 | 41983.02 | 44.0161434 | -| S3c | 17246125 | 0.4636422 | 52687996543 | 3055.063 | 1497.584 | 2219.697 | 193583357 | 11.22475 | 13.67606 | 12.53953 | 70.85627 | 0.0021650 | 32728.09 | 44231.46 | 37.4020651 | -| S3d | 17255729 | 0.4639004 | 52823751959 | 3061.230 | 1497.584 | 2222.960 | 193658024 | 11.22282 | 13.67606 | 12.53800 | 74.11923 | 0.0006413 | 115581.86 | 102994.55 | \-42.0473125 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | --------: | --------: | ----------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 159925565707 | 2149.867 | 0.000 | 2149.867 | 932654398 | 12.53760 | 0.00000 | 12.53760 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74386318 | 1.0000000 | 175298229824 | 2356.592 | 0.000 | 2356.592 | 932770789 | 12.53955 | 0.00000 | 12.53955 | 206.72538 | 0.0019469 | 106179.18 | 125455.61 | \-109.37796 | +| S1b | 74385413 | 1.0000000 | 170952563916 | 2298.200 | 0.000 | 2298.200 | 932704901 | 12.53881 | 0.00000 | 12.53881 | 148.33311 | 0.0012137 | 122210.63 | 162779.03 | \-87.64563 | +| S1c | 74390720 | 1.0000000 | 171904343832 | 2310.830 | 0.000 | 2310.830 | 932748272 | 12.53850 | 0.00000 | 12.53850 | 160.96350 | 0.0009022 | 178404.12 | 270403.20 | \-115.85145 | +| S2NoCD | 44157029 | 0.5935995 | 117807957835 | 2667.932 | 1393.167 | 2149.867 | 541387059 | 12.26050 | 12.94235 | 12.53760 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44154576 | 0.5935665 | 124844786047 | 2827.448 | 1393.167 | 2244.508 | 541466014 | 12.26296 | 12.94235 | 12.53909 | 94.64148 | 0.0014882 | 63595.91 | 64600.18 | \-20.23301 | +| S3NoCD | 34491937 | 0.4636724 | 99999943602 | 2899.227 | 1502.021 | 2149.867 | 387044339 | 11.22130 | 13.67559 | 12.53760 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34494037 | 0.4637007 | 104115381916 | 3018.359 | 1502.021 | 2205.148 | 387129436 | 11.22308 | 13.67559 | 12.53836 | 55.28112 | 0.0007579 | 72940.63 | 66783.39 | \-17.38652 | +| S3b | 34509196 | 0.4639044 | 107308147373 | 3109.552 | 1502.021 | 2247.762 | 387360806 | 11.22486 | 13.67559 | 12.53868 | 97.89513 | 0.0010814 | 90530.10 | 59106.08 | \-43.82740 | +| S3c | 34504471 | 0.4638409 | 105270593424 | 3050.926 | 1502.021 | 2220.467 | 387285272 | 11.22421 | 13.67559 | 12.53854 | 70.59986 | 0.0009346 | 75539.99 | 52193.95 | \-23.86974 | +| S3d | 34501231 | 0.4637974 | 105602366018 | 3060.829 | 1502.021 | 2224.992 | 387258905 | 11.22450 | 13.67559 | 12.53878 | 75.12527 | 0.0011758 | 63893.70 | 50559.69 | \-16.33601 | ![](../../outputs/Sen5_0_Treat_Util_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277801 | 0.1541410 | 0.2732173 | 0.0911566 | 0.4030472 | 0.0760263 | 0.1284096 | 0.0111267 | 0.8424613 | 0.0461119 | 0.0491189 | 0.0110335 | 0.0019273 | 0.3999881 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240553 | 0.1447802 | 0.2157515 | 0.0856247 | 0.4086320 | 0.0767122 | 0.1293709 | 0.0112159 | 0.8424572 | 0.0461045 | 0.0491178 | 0.0110465 | 0.0019286 | 0.2945268 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229349 | 0.1422163 | 0.1962587 | 0.0839634 | 0.4092320 | 0.0769957 | 0.1299784 | 0.0112125 | 0.8424873 | 0.0461079 | 0.0491353 | 0.0110154 | 0.0019116 | 0.2602946 | -| S2NoCD | 0.5934433 | 0.5822732 | 0.7055457 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935356 | 0.5822958 | 0.7060348 | 0.0214261 | 0.1433997 | 0.2089133 | 0.0847853 | 0.4076552 | 0.0767471 | 0.1292182 | 0.0111992 | 0.8425444 | 0.0460948 | 0.0491128 | 0.0109898 | 0.0019109 | 0.2776121 | -| S3NoCD | 0.4638687 | 0.4156354 | 0.5870736 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4637896 | 0.4156229 | 0.5868096 | 0.0197697 | 0.1380286 | 0.1714296 | 0.0812364 | 0.4112879 | 0.0772285 | 0.1300383 | 0.0112027 | 0.8426261 | 0.0461014 | 0.0490230 | 0.0109954 | 0.0019093 | 0.2168391 | -| S3b | 0.4636624 | 0.4156278 | 0.5873096 | 0.0217273 | 0.1440757 | 0.2123156 | 0.0853238 | 0.4076544 | 0.0766218 | 0.1293406 | 0.0111731 | 0.8425735 | 0.0461000 | 0.0490636 | 0.0110097 | 0.0019108 | 0.2840923 | -| S3c | 0.4636422 | 0.4155696 | 0.5876213 | 0.0206711 | 0.1409315 | 0.1917630 | 0.0832429 | 0.4099172 | 0.0770213 | 0.1297097 | 0.0111987 | 0.8425381 | 0.0460824 | 0.0491061 | 0.0110204 | 0.0019145 | 0.2493205 | -| S3d | 0.4639004 | 0.4157123 | 0.5874098 | 0.0202417 | 0.1395900 | 0.1822885 | 0.0822922 | 0.4104446 | 0.0770251 | 0.1298089 | 0.0112098 | 0.8425700 | 0.0461324 | 0.0490486 | 0.0110024 | 0.0019036 | 0.2342313 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277770 | 0.1541676 | 0.2735725 | 0.0911068 | 0.4036872 | 0.0760433 | 0.1284919 | 0.0111234 | 0.8424045 | 0.0461250 | 0.0491350 | 0.0110626 | 0.0019277 | 0.4003768 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240246 | 0.1449184 | 0.2159908 | 0.0856256 | 0.4082615 | 0.0767149 | 0.1294255 | 0.0111919 | 0.8424441 | 0.0461406 | 0.0491198 | 0.0110327 | 0.0019206 | 0.2943838 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229387 | 0.1419011 | 0.1959119 | 0.0838224 | 0.4094144 | 0.0768280 | 0.1296761 | 0.0111991 | 0.8425663 | 0.0460770 | 0.0490825 | 0.0110176 | 0.0019137 | 0.2600889 | +| S2NoCD | 0.5935995 | 0.5823361 | 0.7054688 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5935665 | 0.5824146 | 0.7059463 | 0.0213966 | 0.1438505 | 0.2094804 | 0.0850851 | 0.4086675 | 0.0767385 | 0.1294165 | 0.0112173 | 0.8425126 | 0.0461064 | 0.0490974 | 0.0110198 | 0.0019173 | 0.2779271 | +| S3NoCD | 0.4636724 | 0.4154340 | 0.5860893 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4637007 | 0.4155277 | 0.5865311 | 0.0197899 | 0.1383033 | 0.1717111 | 0.0814794 | 0.4121234 | 0.0772548 | 0.1301283 | 0.0112118 | 0.8425199 | 0.0460735 | 0.0491517 | 0.0110056 | 0.0019051 | 0.2173159 | +| S3b | 0.4639044 | 0.4157857 | 0.5876752 | 0.0217416 | 0.1441790 | 0.2124183 | 0.0853294 | 0.4094186 | 0.0768062 | 0.1294332 | 0.0111818 | 0.8424143 | 0.0460965 | 0.0491883 | 0.0110409 | 0.0019176 | 0.2844185 | +| S3c | 0.4638409 | 0.4156951 | 0.5869250 | 0.0206754 | 0.1410634 | 0.1917068 | 0.0833411 | 0.4105793 | 0.0769845 | 0.1297108 | 0.0112077 | 0.8424894 | 0.0460833 | 0.0491418 | 0.0110239 | 0.0019170 | 0.2496308 | +| S3d | 0.4637974 | 0.4156677 | 0.5868810 | 0.0202585 | 0.1397122 | 0.1824904 | 0.0824625 | 0.4112144 | 0.0771280 | 0.1298555 | 0.0112228 | 0.8424917 | 0.0460937 | 0.0491366 | 0.0110229 | 0.0019114 | 0.2345851 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 14.6137 hours + ## Time difference of 1.315001 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount3yrs.md index 12fd800..04b108e 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 0% Discount Rate ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 92827349205 | 2495.595 | 529928095 | 14.247 | 709840.6 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 92978309019 | 2499.577 | 529999539 | 14.248 | 709910.9 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 92902829112 | 2497.586 | 529963817 | 14.247 | 709875.8 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195779 | 626218800 | 71281372 | 186100281 | 33119195 | 13388772 | 0.026 | 0.159 | 0.310 | 0.094 | 14905588 | 2814123 | 4756454 | 412031 | 0.209 | 0.039 | 0.067 | 0.006 | 527524487 | 28873365 | 30786968 | 6925999 | 1208772 | 105211197489 | 2828.579 | 530667769 | 14.267 | 710515.5 | 332.984 | 0.020 | 16519.74 | 674.853 | -| S1b | 37200476 | 626144172 | 71252445 | 188422793 | 23802097 | 13372758 | 0.022 | 0.148 | 0.240 | 0.088 | 15103031 | 2841048 | 4796549 | 415612 | 0.212 | 0.040 | 0.067 | 0.006 | 527481440 | 28877807 | 30767692 | 6915814 | 1204950 | 101909010383 | 2739.454 | 530366539 | 14.257 | 710109.7 | 243.860 | 0.010 | 23772.81 | 269.037 | -| S1c | 37192813 | 625960445 | 71159107 | 189176712 | 20537777 | 13372239 | 0.020 | 0.144 | 0.214 | 0.085 | 15172732 | 2850944 | 4816068 | 416845 | 0.213 | 0.040 | 0.068 | 0.006 | 527395566 | 28830750 | 30734973 | 6903078 | 1206962 | 102900329678 | 2766.672 | 530129570 | 14.254 | 709910.8 | 271.078 | 0.007 | 39724.27 | 70.121 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | ---------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 185724530860 | 2496.675 | 1059845409 | 14.247 | 709872.8 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 186033235253 | 2500.836 | 1059900380 | 14.248 | 709908.6 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 185878883057 | 2498.755 | 1059872895 | 14.248 | 709890.7 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74380275 | 1252107231 | 142568770 | 372100831 | 66270673 | 26745802 | 0.026 | 0.159 | 0.310 | 0.094 | 29815042 | 5625494 | 9500837 | 824680.0 | 0.209 | 0.039 | 0.067 | 0.006 | 1054730269 | 57758498 | 61574433 | 13835312 | 2423951 | 210298062989 | 2827.336 | 1061052827 | 14.265 | 710434.9 | 330.661 | 0.018 | 18518.39 | 562.130 | +| S1b | 74383024 | 1252030978 | 142410670 | 376764647 | 47607118 | 26748888 | 0.022 | 0.148 | 0.241 | 0.088 | 30192660 | 5683507 | 9596337 | 830158.0 | 0.212 | 0.040 | 0.067 | 0.006 | 1054810413 | 57710159 | 61499603 | 13827904 | 2405886 | 203807677144 | 2739.976 | 1060522850 | 14.258 | 710139.7 | 243.301 | 0.010 | 23844.45 | 266.882 | +| S1c | 74393892 | 1252166867 | 142379318 | 378416895 | 41063274 | 26758496 | 0.020 | 0.144 | 0.214 | 0.085 | 30350312 | 5702044 | 9621386 | 828456.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054965444 | 57726777 | 61483651 | 13803995 | 2400849 | 205585395446 | 2763.471 | 1060470315 | 14.255 | 709976.7 | 266.796 | 0.007 | 35982.42 | 103.935 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22078563 | 364522749 | 50166624 | 110968095 | 9653606 | 7738507 | 0.017 | 0.141 | 0.159 | 0.087 | 11438971 | 2125413 | 3543389 | 304919 | 0.228 | 0.042 | 0.071 | 0.006 | 298790021 | 18633807 | 22502661 | 5543543 | 1025792 | 67978101359 | 3078.919 | 307350490 | 13.921 | 692959.3 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077788 | 364622606 | 50226923 | 108797477 | 18511084 | 7734136 | 0.023 | 0.157 | 0.269 | 0.097 | 11192847 | 2087413 | 3500787 | 300763 | 0.223 | 0.042 | 0.070 | 0.006 | 298828425 | 18622586 | 22524521 | 5579724 | 1036307 | 73774185782 | 3341.557 | 307671898 | 13.936 | 693449.0 | 262.638 | 0.015 | 17454.94 | 489.694 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44156404 | 729084497 | 100330760 | 221928932 | 19330952 | 15481473 | 0.017 | 0.142 | 0.159 | 0.087 | 22917076 | 4253860 | 7098458 | 609501 | 0.228 | 0.042 | 0.071 | 0.006 | 597619551 | 37246010 | 44990133 | 11123560 | 2050468 | 136124332103 | 3082.777 | 614729143 | 13.922 | 692998.8 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44164773 | 729329891 | 100492049 | 217625447 | 37010683 | 15485858 | 0.023 | 0.157 | 0.269 | 0.097 | 22383331 | 4181008 | 7006346 | 603148 | 0.223 | 0.042 | 0.070 | 0.006 | 597700094 | 37284225 | 45068617 | 11147317 | 2064302 | 147612114724 | 3342.304 | 615416266 | 13.935 | 693385.2 | 259.528 | 0.013 | 20087.16 | 386.476 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17243525 | 260017880 | 41691838 | 80059027 | 7819384 | 5815322 | 0.018 | 0.137 | 0.154 | 0.086 | 9754415 | 1816466 | 3038101 | 261338 | 0.234 | 0.044 | 0.073 | 0.006 | 207433146 | 15294590 | 18682841 | 4808648 | 895345 | 57710008552 | 3346.764 | 218436256 | 12.668 | 630039.6 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17245589 | 260114351 | 41778508 | 79305268 | 11012874 | 5816924 | 0.021 | 0.144 | 0.204 | 0.091 | 9648241 | 1803612 | 3027939 | 260144 | 0.231 | 0.043 | 0.072 | 0.006 | 207442211 | 15303706 | 18733677 | 4824249 | 900624 | 61268007225 | 3552.677 | 218598438 | 12.676 | 630228.0 | 205.913 | 0.008 | 26104.20 | 188.493 | -| S3b | 17248093 | 260143539 | 41765340 | 77789956 | 17179218 | 5809490 | 0.027 | 0.156 | 0.293 | 0.099 | 9481831 | 1779958 | 2992091 | 258625 | 0.227 | 0.043 | 0.072 | 0.006 | 207483725 | 15287322 | 18724587 | 4837601 | 899769 | 63624999199 | 3688.814 | 218793327 | 12.685 | 630564.9 | 342.050 | 0.017 | 19717.99 | 525.304 | -| S3c | 17249568 | 260123652 | 41796963 | 78552778 | 14093542 | 5811921 | 0.024 | 0.150 | 0.249 | 0.095 | 9556493 | 1794042 | 3007246 | 258985 | 0.229 | 0.043 | 0.072 | 0.006 | 207434647 | 15324709 | 18727689 | 4823824 | 902793 | 62103127614 | 3600.271 | 218692117 | 12.678 | 630305.8 | 253.507 | 0.010 | 24387.40 | 266.243 | -| S3d | 17250373 | 260166499 | 41788451 | 78909896 | 12694599 | 5812281 | 0.023 | 0.147 | 0.229 | 0.093 | 9596955 | 1798651 | 3013620 | 260246 | 0.230 | 0.043 | 0.072 | 0.006 | 207483596 | 15310784 | 18731510 | 4829309 | 900292 | 62445799074 | 3619.968 | 218689858 | 12.677 | 630250.0 | 273.204 | 0.010 | 28245.66 | 210.417 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34500334 | 520264617 | 83469550 | 160191877 | 15617539 | 11630123 | 0.018 | 0.137 | 0.154 | 0.086 | 19525292 | 3631989 | 6073558 | 522424 | 0.234 | 0.044 | 0.073 | 0.006 | 415002016 | 30608834 | 37422882 | 9624470 | 1788687 | 115393106844 | 3344.695 | 437057823 | 12.668 | 630066.3 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34507415 | 520428951 | 83482576 | 158676520 | 22030098 | 11639538 | 0.021 | 0.144 | 0.204 | 0.091 | 19287934 | 3609226 | 6045313 | 521405 | 0.231 | 0.043 | 0.072 | 0.006 | 415152628 | 30610103 | 37407716 | 9641236 | 1794702 | 122423689898 | 3547.750 | 437381358 | 12.675 | 630202.1 | 203.055 | 0.007 | 29965.58 | 135.759 | +| S3b | 34499539 | 520396932 | 83618002 | 155590263 | 34428826 | 11625591 | 0.027 | 0.156 | 0.293 | 0.099 | 18988453 | 3564625 | 5980823 | 516662 | 0.227 | 0.043 | 0.072 | 0.006 | 414988556 | 30607762 | 37472866 | 9688489 | 1813970 | 127296658689 | 3689.808 | 437670761 | 12.686 | 630624.1 | 345.112 | 0.018 | 19110.81 | 557.812 | +| S3c | 34496334 | 520227370 | 83568351 | 157099275 | 28171361 | 11622564 | 0.024 | 0.150 | 0.249 | 0.095 | 19145218 | 3585036 | 6010150 | 518449 | 0.229 | 0.043 | 0.072 | 0.006 | 414875686 | 30589301 | 37479876 | 9661353 | 1804425 | 124195481660 | 3600.252 | 437363546 | 12.679 | 630327.3 | 255.556 | 0.010 | 24735.86 | 261.014 | +| S3d | 34507664 | 520495018 | 83555471 | 157877292 | 25364366 | 11630839 | 0.023 | 0.147 | 0.229 | 0.093 | 19209915 | 3595849 | 6028084 | 520340 | 0.230 | 0.043 | 0.072 | 0.006 | 415141325 | 30594930 | 37472224 | 9653084 | 1805226 | 124862452609 | 3618.398 | 437518342 | 12.679 | 630325.3 | 273.702 | 0.011 | 25688.98 | 259.021 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S1a | 37195779 | 105211197489 | 2828.579 | 530667769 | 14.267 | 16519.74 | 674.853 | -| S3b | 17248093 | 63624999199 | 3688.814 | 218793327 | 12.685 | 19717.99 | 525.304 | -| S2a | 22077788 | 73774185782 | 3341.557 | 307671898 | 13.936 | 17454.94 | 489.694 | -| S1b | 37200476 | 101909010383 | 2739.454 | 530366539 | 14.257 | 23772.81 | 269.037 | -| S3c | 17249568 | 62103127614 | 3600.271 | 218692117 | 12.678 | 24387.40 | 266.243 | -| S3d | 17250373 | 62445799074 | 3619.968 | 218689858 | 12.677 | 28245.66 | 210.417 | -| S3a | 17245589 | 61268007225 | 3552.677 | 218598438 | 12.676 | 26104.20 | 188.493 | -| S1c | 37192813 | 102900329678 | 2766.672 | 530129570 | 14.254 | 39724.27 | 70.121 | -| S1NoCD | 37196486 | 92827349205 | 2495.595 | 529928095 | 14.247 | NaN | 0.000 | -| S2NoCD | 22078563 | 67978101359 | 3078.919 | 307350490 | 13.921 | NaN | 0.000 | -| S3NoCD | 17243525 | 57710008552 | 3346.764 | 218436256 | 12.668 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | ---------: | ---------: | -------: | -------------: | +| S1a | 74380275 | 210298062989 | 2827.336 | 1061052827 | 14.265 | 18518.39 | 562.130 | +| S3b | 34499539 | 127296658689 | 3689.808 | 437670761 | 12.686 | 19110.81 | 557.812 | +| S2a | 44164773 | 147612114724 | 3342.304 | 615416266 | 13.935 | 20087.16 | 386.476 | +| S1b | 74383024 | 203807677144 | 2739.976 | 1060522850 | 14.258 | 23844.45 | 266.882 | +| S3c | 34496334 | 124195481660 | 3600.252 | 437363546 | 12.679 | 24735.86 | 261.014 | +| S3d | 34507664 | 124862452609 | 3618.398 | 437518342 | 12.679 | 25688.98 | 259.021 | +| S3a | 34507415 | 122423689898 | 3547.750 | 437381358 | 12.675 | 29965.58 | 135.759 | +| S1c | 74393892 | 205585395446 | 2763.471 | 1060470315 | 14.255 | 35982.42 | 103.935 | +| S1NoCD | 74388747 | 185724530860 | 2496.675 | 1059845409 | 14.247 | NaN | 0.000 | +| S2NoCD | 44156404 | 136124332103 | 3082.777 | 614729143 | 13.922 | NaN | 0.000 | +| S3NoCD | 34500334 | 115393106844 | 3344.695 | 437057823 | 12.668 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 92902829112 | 2497.586 | 0.000 | 2497.586 | 529963817 | 14.24747 | 0.00000 | 14.24747 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37195779 | 1.0000000 | 105211197489 | 2828.579 | 0.000 | 2828.579 | 530667769 | 14.26688 | 0.00000 | 14.26688 | 330.99331 | 0.0194141 | 17049.08 | 16519.75 | 639.7140645 | -| S1b | 37200476 | 1.0000000 | 101909010383 | 2739.454 | 0.000 | 2739.454 | 530366539 | 14.25698 | 0.00000 | 14.25698 | 241.86883 | 0.0095153 | 25418.86 | 23772.81 | 233.8977436 | -| S1c | 37192813 | 1.0000000 | 102900329678 | 2766.672 | 0.000 | 2766.672 | 530129570 | 14.25355 | 0.00000 | 14.25355 | 269.08677 | 0.0060814 | 44247.63 | 39724.27 | 34.9823647 | -| S2NoCD | 22078563 | 0.5935568 | 67978101359 | 3078.919 | 1648.625 | 2497.586 | 307350490 | 13.92077 | 14.72457 | 14.24747 | 0.00000 | 0.0000000 | NaN | NaN | 0.0095421 | -| S2a | 22077788 | 0.5935359 | 73774185782 | 3341.557 | 1648.625 | 2653.441 | 307671898 | 13.93581 | 14.72457 | 14.25641 | 155.85541 | 0.0089475 | 17418.94 | 17454.94 | 291.5274921 | -| S3NoCD | 17243525 | 0.4635723 | 57710008552 | 3346.764 | 1763.739 | 2497.586 | 218436256 | 12.66773 | 15.61265 | 14.24747 | 0.00000 | 0.0000000 | NaN | NaN | 0.0095421 | -| S3a | 17245589 | 0.4636278 | 61268007225 | 3552.677 | 1763.739 | 2593.141 | 218598438 | 12.67561 | 15.61265 | 14.25096 | 95.55483 | 0.0034937 | 27350.28 | 26104.20 | 79.1418216 | -| S3b | 17248093 | 0.4636951 | 63624999199 | 3688.814 | 1763.739 | 2656.387 | 218793327 | 12.68507 | 15.61265 | 14.25515 | 158.80112 | 0.0076821 | 20671.57 | 19717.99 | 225.3135261 | -| S3c | 17249568 | 0.4637348 | 62103127614 | 3600.271 | 1763.739 | 2615.403 | 218692117 | 12.67812 | 15.61265 | 14.25181 | 117.81742 | 0.0043421 | 27133.73 | 24387.40 | 99.2972134 | -| S3d | 17250373 | 0.4637564 | 62445799074 | 3619.968 | 1763.739 | 2624.577 | 218689858 | 12.67740 | 15.61265 | 14.25141 | 126.99157 | 0.0039435 | 32202.87 | 28245.66 | 70.1922716 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | ---------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 185878883057 | 2498.755 | 0.000 | 2498.755 | 1059872895 | 14.24779 | 0.00000 | 14.24779 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74380275 | 1.0000000 | 210298062989 | 2827.336 | 0.000 | 2827.336 | 1061052827 | 14.26524 | 0.00000 | 14.26524 | 328.58103 | 0.0174555 | 18823.91 | 18518.39 | 544.19487 | +| S1b | 74383024 | 1.0000000 | 203807677144 | 2739.976 | 0.000 | 2739.976 | 1060522850 | 14.25759 | 0.00000 | 14.25759 | 241.22026 | 0.0098033 | 24605.92 | 23844.45 | 248.94679 | +| S1c | 74393892 | 1.0000000 | 205585395446 | 2763.471 | 0.000 | 2763.471 | 1060470315 | 14.25480 | 0.00000 | 14.25480 | 264.71601 | 0.0070143 | 37739.41 | 35982.42 | 85.99958 | +| S2NoCD | 44156404 | 0.5935911 | 136124332103 | 3082.777 | 1645.748 | 2498.755 | 614729143 | 13.92163 | 14.72417 | 14.24779 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44164773 | 0.5937036 | 147612114724 | 3342.304 | 1645.748 | 2653.000 | 615416266 | 13.93455 | 14.72417 | 14.25537 | 154.24422 | 0.0075804 | 20347.74 | 20087.16 | 224.77627 | +| S3NoCD | 34500334 | 0.4637853 | 115393106844 | 3344.695 | 1767.081 | 2498.755 | 437057823 | 12.66822 | 15.61400 | 14.24779 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34507415 | 0.4638805 | 122423689898 | 3547.750 | 1767.081 | 2593.099 | 437381358 | 12.67500 | 15.61400 | 14.25065 | 94.34338 | 0.0028630 | 32952.94 | 29965.58 | 48.80527 | +| S3b | 34499539 | 0.4637746 | 127296658689 | 3689.808 | 1767.081 | 2658.793 | 437670761 | 12.68628 | 15.61400 | 14.25620 | 160.03741 | 0.0084065 | 19037.24 | 19110.82 | 260.28980 | +| S3c | 34496334 | 0.4637315 | 124195481660 | 3600.252 | 1767.081 | 2617.180 | 437363546 | 12.67855 | 15.61400 | 14.25274 | 118.42466 | 0.0049494 | 23927.08 | 24735.86 | 129.04529 | +| S3d | 34507664 | 0.4638839 | 124862452609 | 3618.398 | 1767.081 | 2625.877 | 437518342 | 12.67887 | 15.61400 | 14.25244 | 127.12156 | 0.0046522 | 27325.23 | 25688.98 | 105.48684 | ![](../../outputs/Sen6_0_Discount_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264130 | 0.1594355 | 0.3100498 | 0.0943012 | 0.4007333 | 0.0756571 | 0.1278762 | 0.0110774 | 0.8423964 | 0.0461075 | 0.0491633 | 0.0110600 | 0.0019303 | 0.4646262 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216055 | 0.1480604 | 0.2404960 | 0.0875941 | 0.4059903 | 0.0763713 | 0.1289378 | 0.0111722 | 0.8424281 | 0.0461201 | 0.0491384 | 0.0110451 | 0.0019244 | 0.3340531 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201493 | 0.1442413 | 0.2143855 | 0.0852093 | 0.4079480 | 0.0766531 | 0.1294892 | 0.0112077 | 0.8425382 | 0.0460584 | 0.0491005 | 0.0110280 | 0.0019282 | 0.2886177 | -| S2NoCD | 0.5935568 | 0.5823097 | 0.7053578 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935359 | 0.5824692 | 0.7062056 | 0.0223351 | 0.1468614 | 0.2290467 | 0.0868672 | 0.4071715 | 0.0764348 | 0.1292457 | 0.0111517 | 0.8425215 | 0.0460676 | 0.0490957 | 0.0110473 | 0.0019254 | 0.3104013 | -| S3NoCD | 0.4635723 | 0.4153676 | 0.5861997 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4636278 | 0.4155217 | 0.5874183 | 0.0201358 | 0.1392626 | 0.1805149 | 0.0822287 | 0.4109128 | 0.0771069 | 0.1301110 | 0.0112307 | 0.8424794 | 0.0461006 | 0.0491419 | 0.0110143 | 0.0019170 | 0.2306846 | -| S3b | 0.4636951 | 0.4155683 | 0.5872332 | 0.0226883 | 0.1466743 | 0.2326983 | 0.0870001 | 0.4064201 | 0.0764674 | 0.1291411 | 0.0111894 | 0.8425049 | 0.0460727 | 0.0491259 | 0.0110354 | 0.0019156 | 0.3174192 | -| S3c | 0.4637348 | 0.4155365 | 0.5876778 | 0.0213351 | 0.1429510 | 0.2072023 | 0.0845726 | 0.4084161 | 0.0768439 | 0.1295450 | 0.0111987 | 0.8424543 | 0.0461336 | 0.0491319 | 0.0110136 | 0.0019205 | 0.2739520 | -| S3d | 0.4637564 | 0.4156050 | 0.5875581 | 0.0207664 | 0.1413812 | 0.1952106 | 0.0835996 | 0.4094977 | 0.0769666 | 0.1297144 | 0.0112325 | 0.8424726 | 0.0461088 | 0.0491357 | 0.0110219 | 0.0019164 | 0.2543044 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264033 | 0.1593018 | 0.3099946 | 0.0940914 | 0.4008461 | 0.0756315 | 0.1277333 | 0.0110873 | 0.8423642 | 0.0461290 | 0.0491766 | 0.0110496 | 0.0019359 | 0.4648330 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216398 | 0.1482342 | 0.2406521 | 0.0877947 | 0.4059079 | 0.0764087 | 0.1290125 | 0.0111606 | 0.8424795 | 0.0460932 | 0.0491199 | 0.0110444 | 0.0019216 | 0.3342946 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201517 | 0.1441110 | 0.2141912 | 0.0851720 | 0.4079678 | 0.0766467 | 0.1293303 | 0.0111361 | 0.8425119 | 0.0461015 | 0.0491018 | 0.0110241 | 0.0019174 | 0.2884076 | +| S2NoCD | 0.5935911 | 0.5823656 | 0.7051165 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5937036 | 0.5825616 | 0.7062500 | 0.0223572 | 0.1465203 | 0.2287835 | 0.0867962 | 0.4069072 | 0.0764858 | 0.1291620 | 0.0111850 | 0.8424534 | 0.0460995 | 0.0491621 | 0.0110233 | 0.0019191 | 0.3102030 | +| S3NoCD | 0.4637853 | 0.4155681 | 0.5866172 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4638805 | 0.4156993 | 0.5867088 | 0.0201156 | 0.1395918 | 0.1808230 | 0.0824771 | 0.4108939 | 0.0771596 | 0.1300215 | 0.0112568 | 0.8425660 | 0.0460728 | 0.0490892 | 0.0110179 | 0.0019129 | 0.2311946 | +| S3b | 0.4637746 | 0.4156737 | 0.5876605 | 0.0227032 | 0.1471017 | 0.2332507 | 0.0873282 | 0.4068980 | 0.0765657 | 0.1291642 | 0.0111939 | 0.8424573 | 0.0460719 | 0.0491421 | 0.0110558 | 0.0019283 | 0.3181560 | +| S3c | 0.4637315 | 0.4155383 | 0.5873116 | 0.0213262 | 0.1432680 | 0.2074859 | 0.0848645 | 0.4090175 | 0.0768424 | 0.1295624 | 0.0112182 | 0.8424856 | 0.0460621 | 0.0491521 | 0.0110349 | 0.0019208 | 0.2742435 | +| S3d | 0.4638839 | 0.4157521 | 0.5872211 | 0.0207546 | 0.1415673 | 0.1954816 | 0.0837051 | 0.4098442 | 0.0769796 | 0.1297896 | 0.0112424 | 0.8425108 | 0.0460587 | 0.0491390 | 0.0110271 | 0.0019212 | 0.2545329 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 16.08891 hours + ## Time difference of 1.148049 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount5yrs.md index ceed09b..f2d6f8c 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen6_0_Discount5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 0% Discount Rate ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD2 | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 92827349205 | 2495.595 | 529928095 | 14.247 | 709840.6 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 92978309019 | 2499.577 | 529999539 | 14.248 | 709910.9 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 92902829112 | 2497.586 | 529963817 | 14.247 | 709875.8 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37197502 | 626089853 | 71222084 | 122776626 | 28487983 | 16327137 | 0.028 | 0.154 | 0.273 | 0.091 | 14992350 | 2827989 | 4776515 | 413886 | 0.211 | 0.040 | 0.067 | 0.006 | 527456443 | 28870190 | 30752817 | 6907934 | 1206659 | 101593628148 | 2731.195 | 530443727 | 14.260 | 710278.7 | 231.618 | 0.012 | 19321.34 | 367.766 | -| S1b | 37190655 | 625992698 | 71214502 | 123717512 | 20974578 | 16327973 | 0.024 | 0.145 | 0.216 | 0.086 | 15197291 | 2852978 | 4811387 | 417126 | 0.213 | 0.040 | 0.068 | 0.006 | 527372066 | 28861102 | 30747408 | 6915037 | 1207305 | 99147551251 | 2665.926 | 530160006 | 14.255 | 710093.8 | 166.350 | 0.007 | 23817.89 | 182.862 | -| S1c | 37195162 | 626110982 | 71210037 | 124047387 | 18535585 | 16324587 | 0.023 | 0.142 | 0.196 | 0.084 | 15221449 | 2863867 | 4834566 | 417049 | 0.214 | 0.040 | 0.068 | 0.006 | 527490541 | 28868640 | 30764128 | 6896850 | 1196858 | 99801217926 | 2683.177 | 530199955 | 14.255 | 710043.9 | 183.601 | 0.006 | 29000.47 | 132.947 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | ---------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD2 | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 185724530860 | 2496.675 | 1059845409 | 14.247 | 709872.8 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 186033235253 | 2500.836 | 1059900380 | 14.248 | 709908.6 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 185878883057 | 2498.755 | 1059872895 | 14.248 | 709890.7 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386318 | 1252092577 | 142511621 | 245523949 | 57058349 | 32655914 | 0.028 | 0.154 | 0.274 | 0.091 | 30028808 | 5656584 | 9558038 | 827432.0 | 0.211 | 0.040 | 0.067 | 0.006 | 1054768469 | 57752767 | 61521629 | 13851433 | 2413714 | 203290806711 | 2732.906 | 1060803037 | 14.261 | 710303.5 | 232.070 | 0.013 | 18508.89 | 394.845 | +| S1b | 74385413 | 1252007176 | 142455061 | 247448362 | 41936466 | 32651747 | 0.024 | 0.145 | 0.216 | 0.086 | 30368698 | 5706469 | 9627370 | 832514.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054746061 | 57768304 | 61498391 | 13812986 | 2404656 | 198298896720 | 2665.830 | 1060342609 | 14.255 | 710069.7 | 164.995 | 0.007 | 25298.01 | 161.107 | +| S1c | 74390720 | 1252048091 | 142295860 | 248074520 | 37009576 | 32668233 | 0.023 | 0.142 | 0.196 | 0.084 | 30456632 | 5715293 | 9646702 | 833108.0 | 0.214 | 0.040 | 0.068 | 0.006 | 1054933501 | 57690667 | 61453687 | 13794504 | 2396041 | 199278771241 | 2678.812 | 1060261851 | 14.253 | 709951.6 | 177.976 | 0.004 | 40270.48 | 43.000 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22074342 | 364499893 | 50179989 | 72492409 | 9769650 | 9434235 | 0.021 | 0.142 | 0.160 | 0.087 | 11472370 | 2126666 | 3551252 | 304704 | 0.229 | 0.042 | 0.071 | 0.006 | 298757005 | 18626945 | 22501053 | 5562438 | 1027303 | 68198452610 | 3089.490 | 307327847 | 13.922 | 693030.6 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077777 | 364514086 | 50214779 | 71673455 | 16290550 | 9435494 | 0.025 | 0.153 | 0.241 | 0.095 | 11245330 | 2100490 | 3507989 | 302346 | 0.224 | 0.042 | 0.070 | 0.006 | 298734836 | 18629376 | 22530917 | 5562183 | 1028646 | 72055390304 | 3263.707 | 307521349 | 13.929 | 693186.3 | 174.217 | 0.007 | 26402.81 | 155.704 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | ----: | -------------: | +| S2NoCD | 44157029 | 729047563 | 100380900 | 145000421 | 19524492 | 18863743 | 0.021 | 0.142 | 0.160 | 0.087 | 22925265 | 4254784 | 7099566 | 609563 | 0.228 | 0.042 | 0.071 | 0.006 | 597538799 | 37245010 | 45040554 | 11117169 | 2054803 | 136358873737 | 3088.045 | 614694012 | 13.921 | 692943.9 | 0.000 | 0.000 | NaN | 0.000 | +| S2a | 44154576 | 729145856 | 100448839 | 143361789 | 32595478 | 18878233 | 0.025 | 0.154 | 0.242 | 0.095 | 22519648 | 4200194 | 7025459 | 605531 | 0.224 | 0.042 | 0.070 | 0.006 | 597564735 | 37286040 | 45033303 | 11135908 | 2066352 | 144286219339 | 3267.752 | 615140303 | 13.932 | 693308.2 | 179.708 | 0.011 | 16516 | 364.334 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17254548 | 260185517 | 41753987 | 52456874 | 7922835 | 7061036 | 0.022 | 0.137 | 0.155 | 0.086 | 9767617 | 1818208 | 3040076 | 262205 | 0.234 | 0.044 | 0.073 | 0.006 | 207533583 | 15301679 | 18724752 | 4815426 | 897482 | 57864310924 | 3353.569 | 218572819 | 12.668 | 630023.8 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17251608 | 260177738 | 41735217 | 52193377 | 10112286 | 7056308 | 0.024 | 0.142 | 0.189 | 0.089 | 9673981 | 1809610 | 3026757 | 259927 | 0.232 | 0.043 | 0.073 | 0.006 | 207543323 | 15307443 | 18697708 | 4818609 | 897810 | 60089152168 | 3483.104 | 218633446 | 12.673 | 630178.0 | 129.536 | 0.006 | 22833.54 | 154.117 | -| S3b | 17246874 | 260180750 | 41770771 | 51592135 | 14901907 | 7060341 | 0.029 | 0.152 | 0.258 | 0.096 | 9537491 | 1786791 | 3000373 | 258790 | 0.228 | 0.043 | 0.072 | 0.006 | 207513062 | 15306657 | 18723252 | 4827550 | 898750 | 61869748507 | 3587.302 | 218763933 | 12.684 | 630626.0 | 233.734 | 0.017 | 13981.39 | 602.140 | -| S3c | 17246125 | 260144350 | 41792942 | 51894923 | 12432863 | 7060467 | 0.026 | 0.147 | 0.223 | 0.093 | 9621451 | 1801612 | 3014035 | 259735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459068 | 15294280 | 18748666 | 4834049 | 901039 | 60807623938 | 3525.872 | 218659412 | 12.679 | 630411.9 | 172.303 | 0.011 | 15373.49 | 388.087 | -| S3d | 17255729 | 260233694 | 41777900 | 52047317 | 11356970 | 7062160 | 0.025 | 0.144 | 0.207 | 0.091 | 9643777 | 1802264 | 3018596 | 260225 | 0.231 | 0.043 | 0.072 | 0.006 | 207557193 | 15328896 | 18715546 | 4823282 | 894293 | 60941413668 | 3531.663 | 218712958 | 12.675 | 630208.5 | 178.094 | 0.007 | 24550.12 | 184.621 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34491937 | 520096794 | 83394436 | 104866546 | 15798844 | 14116443 | 0.022 | 0.137 | 0.154 | 0.086 | 19479590 | 3630576 | 6075819 | 523166 | 0.234 | 0.044 | 0.073 | 0.006 | 414917152 | 30599570 | 37365292 | 9614469 | 1790750 | 115570166575 | 3350.643 | 436927836 | 12.668 | 630026.1 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34494037 | 520214111 | 83457293 | 104351592 | 20245608 | 14129448 | 0.024 | 0.142 | 0.189 | 0.089 | 19332282 | 3614629 | 6055063 | 518761 | 0.232 | 0.043 | 0.073 | 0.006 | 414968911 | 30599997 | 37426814 | 9615582 | 1787056 | 120160874413 | 3483.526 | 437149998 | 12.673 | 630176.7 | 132.883 | 0.006 | 23438.76 | 150.586 | +| S3b | 34509196 | 520537138 | 83620081 | 103218767 | 29823148 | 14132996 | 0.029 | 0.152 | 0.258 | 0.096 | 19135380 | 3582069 | 6004729 | 516649 | 0.229 | 0.043 | 0.072 | 0.006 | 415119150 | 30640730 | 37483240 | 9661621 | 1802895 | 123796077467 | 3587.336 | 437667749 | 12.683 | 630544.7 | 236.693 | 0.015 | 15669.18 | 518.589 | +| S3c | 34504471 | 520423616 | 83513343 | 103824096 | 24853847 | 14121585 | 0.026 | 0.146 | 0.223 | 0.093 | 19220385 | 3595075 | 6024956 | 518536 | 0.230 | 0.043 | 0.072 | 0.006 | 415113845 | 30619979 | 37421385 | 9639642 | 1802009 | 121485915694 | 3520.875 | 437449142 | 12.678 | 630381.2 | 170.232 | 0.011 | 16202.08 | 355.107 | +| S3d | 34501231 | 520389346 | 83507084 | 104079260 | 22711874 | 14135933 | 0.025 | 0.144 | 0.207 | 0.091 | 19266710 | 3605577 | 6035420 | 519637 | 0.231 | 0.043 | 0.072 | 0.006 | 415086795 | 30631737 | 37413709 | 9638221 | 1794998 | 121822210448 | 3530.953 | 437363185 | 12.677 | 630306.1 | 180.310 | 0.009 | 19586.22 | 279.987 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S3b | 17246874 | 61869748507 | 3587.302 | 218763933 | 12.684 | 13981.39 | 602.140 | -| S3c | 17246125 | 60807623938 | 3525.872 | 218659412 | 12.679 | 15373.49 | 388.087 | -| S1a | 37197502 | 101593628148 | 2731.195 | 530443727 | 14.260 | 19321.34 | 367.766 | -| S3d | 17255729 | 60941413668 | 3531.663 | 218712958 | 12.675 | 24550.12 | 184.621 | -| S1b | 37190655 | 99147551251 | 2665.926 | 530160006 | 14.255 | 23817.89 | 182.862 | -| S2a | 22077777 | 72055390304 | 3263.707 | 307521349 | 13.929 | 26402.81 | 155.704 | -| S3a | 17251608 | 60089152168 | 3483.104 | 218633446 | 12.673 | 22833.54 | 154.117 | -| S1c | 37195162 | 99801217926 | 2683.177 | 530199955 | 14.255 | 29000.47 | 132.947 | -| S1NoCD | 37197623 | 92978309019 | 2499.577 | 529999539 | 14.248 | NaN | 0.000 | -| S2NoCD | 22074342 | 68198452610 | 3089.490 | 307327847 | 13.922 | NaN | 0.000 | -| S3NoCD | 17254548 | 57864310924 | 3353.569 | 218572819 | 12.668 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | ---------: | ---------: | -------: | -------------: | +| S3b | 34509196 | 123796077467 | 3587.336 | 437667749 | 12.683 | 15669.18 | 518.589 | +| S1a | 74386318 | 203290806711 | 2732.906 | 1060803037 | 14.261 | 18508.89 | 394.845 | +| S2a | 44154576 | 144286219339 | 3267.752 | 615140303 | 13.932 | 16516.00 | 364.334 | +| S3c | 34504471 | 121485915694 | 3520.875 | 437449142 | 12.678 | 16202.08 | 355.107 | +| S3d | 34501231 | 121822210448 | 3530.953 | 437363185 | 12.677 | 19586.22 | 279.987 | +| S1b | 74385413 | 198298896720 | 2665.830 | 1060342609 | 14.255 | 25298.01 | 161.107 | +| S3a | 34494037 | 120160874413 | 3483.526 | 437149998 | 12.673 | 23438.76 | 150.586 | +| S1c | 74390720 | 199278771241 | 2678.812 | 1060261851 | 14.253 | 40270.48 | 43.000 | +| S1NoCD | 74388425 | 186033235253 | 2500.836 | 1059900380 | 14.248 | NaN | 0.000 | +| S2NoCD | 44157029 | 136358873737 | 3088.045 | 614694012 | 13.921 | NaN | 0.000 | +| S3NoCD | 34491937 | 115570166575 | 3350.643 | 436927836 | 12.668 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ----------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 92902829112 | 2497.586 | 0.000 | 2497.586 | 529963817 | 14.24747 | 0.00000 | 14.24747 | 0.00000 | 0.0000000 | NaN | NaN | 0.0000000 | -| S1a | 37197502 | 1.0000000 | 101593628148 | 2731.195 | 0.000 | 2731.195 | 530443727 | 14.26020 | 0.00000 | 14.26020 | 233.60927 | 0.0127303 | 18350.69 | 19321.34 | 402.9042829 | -| S1b | 37190655 | 1.0000000 | 99147551251 | 2665.926 | 0.000 | 2665.926 | 530160006 | 14.25519 | 0.00000 | 14.25519 | 168.34082 | 0.0077268 | 21786.57 | 23817.89 | 218.0000651 | -| S1c | 37195162 | 1.0000000 | 99801217926 | 2683.177 | 0.000 | 2683.177 | 530199955 | 14.25454 | 0.00000 | 14.25454 | 185.59176 | 0.0070735 | 26237.47 | 29000.47 | 168.0851524 | -| S2NoCD | 22074342 | 0.5934433 | 68198452610 | 3089.490 | 1633.594 | 2497.586 | 307327847 | 13.92240 | 14.72196 | 14.24747 | 0.00000 | 0.0000000 | NaN | NaN | 0.0095421 | -| S2a | 22077777 | 0.5935356 | 72055390304 | 3263.707 | 1633.594 | 2601.124 | 307521349 | 13.92900 | 14.72196 | 14.25131 | 103.53848 | 0.0038426 | 26945.14 | 26402.82 | 88.5993423 | -| S3NoCD | 17254548 | 0.4638687 | 57864310924 | 3353.569 | 1756.977 | 2497.586 | 218572819 | 12.66755 | 15.61444 | 14.24747 | 0.00000 | 0.0000000 | NaN | NaN | 0.0095421 | -| S3a | 17251608 | 0.4637896 | 60089152168 | 3483.104 | 1756.977 | 2557.537 | 218633446 | 12.67322 | 15.61444 | 14.25033 | 59.95117 | 0.0028640 | 20932.53 | 22833.54 | 83.2593204 | -| S3b | 17246874 | 0.4636624 | 61869748507 | 3587.302 | 1756.977 | 2605.630 | 218763933 | 12.68427 | 15.61444 | 14.25583 | 108.04406 | 0.0083592 | 12925.12 | 13981.39 | 309.9268562 | -| S3c | 17246125 | 0.4636422 | 60807623938 | 3525.872 | 1756.977 | 2577.111 | 218659412 | 12.67876 | 15.61444 | 14.25333 | 79.52544 | 0.0058637 | 13562.30 | 15373.49 | 213.6697731 | -| S3d | 17255729 | 0.4639004 | 60941413668 | 3531.663 | 1756.977 | 2580.254 | 218712958 | 12.67480 | 15.61444 | 14.25074 | 82.66858 | 0.0032717 | 25267.69 | 24550.12 | 80.9265349 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | ---------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 185878883057 | 2498.755 | 0.000 | 2498.755 | 1059872895 | 14.24779 | 0.00000 | 14.24779 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74386318 | 1.0000000 | 203290806711 | 2732.906 | 0.000 | 2732.906 | 1060803037 | 14.26073 | 0.00000 | 14.26073 | 234.15046 | 0.0129386 | 18097.02 | 18508.89 | 412.78069 | +| S1b | 74385413 | 1.0000000 | 198298896720 | 2665.830 | 0.000 | 2665.830 | 1060342609 | 14.25471 | 0.00000 | 14.25471 | 167.07499 | 0.0069224 | 24135.55 | 25298.01 | 179.04299 | +| S1c | 74390720 | 1.0000000 | 199278771241 | 2678.812 | 0.000 | 2678.812 | 1060261851 | 14.25261 | 0.00000 | 14.25261 | 180.05681 | 0.0048198 | 37357.37 | 40270.48 | 60.93551 | +| S2NoCD | 44157029 | 0.5935995 | 136358873737 | 3088.045 | 1638.024 | 2498.755 | 614694012 | 13.92064 | 14.72564 | 14.24779 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44154576 | 0.5935665 | 144286219339 | 3267.752 | 1638.024 | 2605.376 | 615140303 | 13.93152 | 14.72564 | 14.25427 | 106.62071 | 0.0064850 | 16441.02 | 16516.00 | 217.63136 | +| S3NoCD | 34491937 | 0.4636724 | 115570166575 | 3350.643 | 1762.271 | 2498.755 | 436927836 | 12.66754 | 15.61397 | 14.24779 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34494037 | 0.4637007 | 120160874413 | 3483.526 | 1762.271 | 2560.418 | 437149998 | 12.67320 | 15.61397 | 14.25033 | 61.66278 | 0.0025457 | 24222.21 | 23438.76 | 65.62285 | +| S3b | 34509196 | 0.4639044 | 123796077467 | 3587.336 | 1762.271 | 2608.927 | 437667749 | 12.68264 | 15.61397 | 14.25411 | 110.17142 | 0.0063240 | 17421.26 | 15669.18 | 206.02677 | +| S3c | 34504471 | 0.4638409 | 121485915694 | 3520.875 | 1762.271 | 2577.983 | 437449142 | 12.67804 | 15.61397 | 14.25217 | 79.22803 | 0.0043770 | 18100.91 | 16202.08 | 139.62291 | +| S3d | 34501231 | 0.4637974 | 121822210448 | 3530.953 | 1762.271 | 2582.581 | 437363185 | 12.67674 | 15.61397 | 14.25169 | 83.82557 | 0.0039016 | 21485.10 | 19586.22 | 111.25281 | ![](../../outputs/Sen6_0_Discount_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277801 | 0.1541410 | 0.2732173 | 0.0911566 | 0.4030472 | 0.0760263 | 0.1284096 | 0.0111267 | 0.8424613 | 0.0461119 | 0.0491189 | 0.0110335 | 0.0019273 | 0.3999881 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240553 | 0.1447802 | 0.2157515 | 0.0856247 | 0.4086320 | 0.0767122 | 0.1293709 | 0.0112159 | 0.8424572 | 0.0461045 | 0.0491178 | 0.0110465 | 0.0019286 | 0.2945268 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229349 | 0.1422163 | 0.1962587 | 0.0839634 | 0.4092320 | 0.0769957 | 0.1299784 | 0.0112125 | 0.8424873 | 0.0461079 | 0.0491353 | 0.0110154 | 0.0019116 | 0.2602946 | -| S2NoCD | 0.5934433 | 0.5822732 | 0.7055457 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935356 | 0.5822958 | 0.7060348 | 0.0214261 | 0.1433997 | 0.2089133 | 0.0847853 | 0.4076552 | 0.0767471 | 0.1292182 | 0.0111992 | 0.8425444 | 0.0460948 | 0.0491128 | 0.0109898 | 0.0019109 | 0.2776121 | -| S3NoCD | 0.4638687 | 0.4156354 | 0.5870736 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4637896 | 0.4156229 | 0.5868096 | 0.0197697 | 0.1380286 | 0.1714296 | 0.0812364 | 0.4112879 | 0.0772285 | 0.1300383 | 0.0112027 | 0.8426261 | 0.0461014 | 0.0490230 | 0.0109954 | 0.0019093 | 0.2168391 | -| S3b | 0.4636624 | 0.4156278 | 0.5873096 | 0.0217273 | 0.1440757 | 0.2123156 | 0.0853238 | 0.4076544 | 0.0766218 | 0.1293406 | 0.0111731 | 0.8425735 | 0.0461000 | 0.0490636 | 0.0110097 | 0.0019108 | 0.2840923 | -| S3c | 0.4636422 | 0.4155696 | 0.5876213 | 0.0206711 | 0.1409315 | 0.1917630 | 0.0832429 | 0.4099172 | 0.0770213 | 0.1297097 | 0.0111987 | 0.8425381 | 0.0460824 | 0.0491061 | 0.0110204 | 0.0019145 | 0.2493205 | -| S3d | 0.4639004 | 0.4157123 | 0.5874098 | 0.0202417 | 0.1395900 | 0.1822885 | 0.0822922 | 0.4104446 | 0.0770251 | 0.1298089 | 0.0112098 | 0.8425700 | 0.0461324 | 0.0490486 | 0.0110024 | 0.0019036 | 0.2342313 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277770 | 0.1541676 | 0.2735725 | 0.0911068 | 0.4036872 | 0.0760433 | 0.1284919 | 0.0111234 | 0.8424045 | 0.0461250 | 0.0491350 | 0.0110626 | 0.0019277 | 0.4003768 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240246 | 0.1449184 | 0.2159908 | 0.0856256 | 0.4082615 | 0.0767149 | 0.1294255 | 0.0111919 | 0.8424441 | 0.0461406 | 0.0491198 | 0.0110327 | 0.0019206 | 0.2943838 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229387 | 0.1419011 | 0.1959119 | 0.0838224 | 0.4094144 | 0.0768280 | 0.1296761 | 0.0111991 | 0.8425663 | 0.0460770 | 0.0490825 | 0.0110176 | 0.0019137 | 0.2600889 | +| S2NoCD | 0.5935995 | 0.5823361 | 0.7054688 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5935665 | 0.5824146 | 0.7059463 | 0.0213966 | 0.1438505 | 0.2094804 | 0.0850851 | 0.4086675 | 0.0767385 | 0.1294165 | 0.0112173 | 0.8425126 | 0.0461064 | 0.0490974 | 0.0110198 | 0.0019173 | 0.2779271 | +| S3NoCD | 0.4636724 | 0.4154340 | 0.5860893 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4637007 | 0.4155277 | 0.5865311 | 0.0197899 | 0.1383033 | 0.1717111 | 0.0814794 | 0.4121234 | 0.0772548 | 0.1301283 | 0.0112118 | 0.8425199 | 0.0460735 | 0.0491517 | 0.0110056 | 0.0019051 | 0.2173159 | +| S3b | 0.4639044 | 0.4157857 | 0.5876752 | 0.0217416 | 0.1441790 | 0.2124183 | 0.0853294 | 0.4094186 | 0.0768062 | 0.1294332 | 0.0111818 | 0.8424143 | 0.0460965 | 0.0491883 | 0.0110409 | 0.0019176 | 0.2844185 | +| S3c | 0.4638409 | 0.4156951 | 0.5869250 | 0.0206754 | 0.1410634 | 0.1917068 | 0.0833411 | 0.4105793 | 0.0769845 | 0.1297108 | 0.0112077 | 0.8424894 | 0.0460833 | 0.0491418 | 0.0110239 | 0.0019170 | 0.2496308 | +| S3d | 0.4637974 | 0.4156677 | 0.5868810 | 0.0202585 | 0.1397122 | 0.1824904 | 0.0824625 | 0.4112144 | 0.0771280 | 0.1298555 | 0.0112228 | 0.8424917 | 0.0460937 | 0.0491366 | 0.0110229 | 0.0019114 | 0.2345851 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 13.80011 hours + ## Time difference of 1.163011 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount3yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount3yrs.md index e763f2e..c953f5f 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount3yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount3yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 3% Discount Rate ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 69325010796 | 1863.752 | 414511485 | 11.144 | 555328.0 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD2 | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 69440018935 | 1866.786 | 414564642 | 11.145 | 555379.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 69382514865 | 1865.269 | 414538063 | 11.144 | 555353.7 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37195779 | 626218800 | 71281372 | 186100281 | 33119195 | 13388772 | 0.026 | 0.159 | 0.310 | 0.094 | 14905588 | 2814123 | 4756454 | 412031 | 0.209 | 0.039 | 0.067 | 0.006 | 527524487 | 28873365 | 30786968 | 6925999 | 1208772 | 78988588613 | 2123.590 | 415048183 | 11.158 | 555800.2 | 259.839 | 0.015 | 17747.53 | 472.203 | -| S1b | 37200476 | 626144172 | 71252445 | 188422793 | 23802097 | 13372758 | 0.022 | 0.148 | 0.240 | 0.088 | 15103031 | 2841048 | 4796549 | 415612 | 0.212 | 0.040 | 0.067 | 0.006 | 527481440 | 28877807 | 30767692 | 6915814 | 1204950 | 76461197768 | 2055.382 | 414832042 | 11.151 | 555507.4 | 191.631 | 0.007 | 25820.11 | 179.457 | -| S1c | 37192813 | 625960445 | 71159107 | 189176712 | 20537777 | 13372239 | 0.020 | 0.144 | 0.214 | 0.085 | 15172732 | 2850944 | 4816068 | 416845 | 0.213 | 0.040 | 0.068 | 0.006 | 527395566 | 28830750 | 30734973 | 6903078 | 1206962 | 77318972106 | 2078.869 | 414653653 | 11.149 | 555359.0 | 215.117 | 0.005 | 43696.51 | 31.032 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 138701936801 | 1864.555 | 829008490 | 11.144 | 555349.1 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD2 | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 138942645767 | 1867.799 | 829048977 | 11.145 | 555375.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 138822291284 | 1866.177 | 829028734 | 11.145 | 555362.3 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74380275 | 1252107231 | 142568770 | 372100831 | 66270673 | 26745802 | 0.026 | 0.159 | 0.310 | 0.094 | 29815042 | 5625494 | 9500837 | 824680.0 | 0.209 | 0.039 | 0.067 | 0.006 | 1054730269 | 57758498 | 61574433 | 13835312 | 2423951 | 157886317266 | 2122.691 | 829882713 | 11.157 | 555742.1 | 258.135 | 0.013 | 19821.86 | 393.003 | +| S1b | 74383024 | 1252030978 | 142410670 | 376764647 | 47607118 | 26748888 | 0.022 | 0.148 | 0.241 | 0.088 | 30192660 | 5683507 | 9596337 | 830158.0 | 0.212 | 0.040 | 0.067 | 0.006 | 1054810413 | 57710159 | 61499603 | 13827904 | 2405886 | 152914677120 | 2055.774 | 829494032 | 11.152 | 555527.1 | 191.219 | 0.007 | 25892.74 | 178.033 | +| S1c | 74393892 | 1252166867 | 142379318 | 378416895 | 41063274 | 26758496 | 0.020 | 0.144 | 0.214 | 0.085 | 30350312 | 5702044 | 9621386 | 828456.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054965444 | 57726777 | 61483651 | 13803995 | 2400849 | 154475292879 | 2076.451 | 829462690 | 11.150 | 555403.9 | 211.896 | 0.005 | 39721.03 | 54.834 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22078563 | 364522749 | 50166624 | 110968095 | 9653606 | 7738507 | 0.017 | 0.141 | 0.159 | 0.087 | 11438971 | 2125413 | 3543389 | 304919 | 0.228 | 0.042 | 0.071 | 0.006 | 298790021 | 18633807 | 22502661 | 5543543 | 1025792 | 51195392088 | 2318.783 | 240914015 | 10.912 | 543264.8 | 0.000 | 0.000 | NaN | 0.000 | -| S2a | 22077788 | 364622606 | 50226923 | 108797477 | 18511084 | 7734136 | 0.023 | 0.157 | 0.269 | 0.097 | 11192847 | 2087413 | 3500787 | 300763 | 0.223 | 0.042 | 0.070 | 0.006 | 298828425 | 18622586 | 22524521 | 5579724 | 1036307 | 55740228537 | 2524.720 | 241147117 | 10.923 | 543605.9 | 205.937 | 0.011 | 18822.07 | 341.126 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44156404 | 729084497 | 100330760 | 221928932 | 19330952 | 15481473 | 0.017 | 0.142 | 0.159 | 0.087 | 22917076 | 4253860 | 7098458 | 609501 | 0.228 | 0.042 | 0.071 | 0.006 | 597619551 | 37246010 | 44990133 | 11123560 | 2050468 | 102511836117 | 2321.562 | 481847558 | 10.912 | 543293.0 | 0.000 | 0.00 | NaN | 0.000 | +| S2a | 44164773 | 729329891 | 100492049 | 217625447 | 37010683 | 15485858 | 0.023 | 0.157 | 0.269 | 0.097 | 22383331 | 4181008 | 7006346 | 603148 | 0.223 | 0.042 | 0.070 | 0.006 | 597700094 | 37284225 | 45068617 | 11147317 | 2064302 | 111527223359 | 2525.253 | 482358789 | 10.922 | 543564.7 | 203.691 | 0.01 | 21423.74 | 271.695 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17243525 | 260017880 | 41691838 | 80059027 | 7819384 | 5815322 | 0.018 | 0.137 | 0.154 | 0.086 | 9754415 | 1816466 | 3038101 | 261338 | 0.234 | 0.044 | 0.073 | 0.006 | 207433146 | 15294590 | 18682841 | 4808648 | 895345 | 43585079096 | 2527.620 | 173193983 | 10.044 | 499672.4 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17245589 | 260114351 | 41778508 | 79305268 | 11012874 | 5816924 | 0.021 | 0.144 | 0.204 | 0.091 | 9648241 | 1803612 | 3027939 | 260144 | 0.231 | 0.043 | 0.072 | 0.006 | 207442211 | 15303706 | 18733677 | 4824249 | 900624 | 46423704300 | 2691.918 | 173312928 | 10.050 | 499792.9 | 164.298 | 0.006 | 28849.33 | 120.454 | -| S3b | 17248093 | 260143539 | 41765340 | 77789956 | 17179218 | 5809490 | 0.027 | 0.156 | 0.293 | 0.099 | 9481831 | 1779958 | 2992091 | 258625 | 0.227 | 0.043 | 0.072 | 0.006 | 207483725 | 15287322 | 18724587 | 4837601 | 899769 | 48252461324 | 2797.553 | 173460431 | 10.057 | 500041.9 | 269.933 | 0.013 | 21108.54 | 369.460 | -| S3c | 17249568 | 260123652 | 41796963 | 78552778 | 14093542 | 5811921 | 0.024 | 0.150 | 0.249 | 0.095 | 9556493 | 1794042 | 3007246 | 258985 | 0.229 | 0.043 | 0.072 | 0.006 | 207434647 | 15324709 | 18727689 | 4823824 | 902793 | 47056539449 | 2727.984 | 173385532 | 10.052 | 499851.4 | 200.364 | 0.008 | 26412.71 | 178.930 | -| S3d | 17250373 | 260166499 | 41788451 | 78909896 | 12694599 | 5812281 | 0.023 | 0.147 | 0.229 | 0.093 | 9596955 | 1798651 | 3013620 | 260246 | 0.230 | 0.043 | 0.072 | 0.006 | 207483596 | 15310784 | 18731510 | 4829309 | 900292 | 47356022542 | 2745.217 | 173385479 | 10.051 | 499810.5 | 217.597 | 0.007 | 30588.27 | 138.090 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34500334 | 520264617 | 83469550 | 160191877 | 15617539 | 11630123 | 0.018 | 0.137 | 0.154 | 0.086 | 19525292 | 3631989 | 6073558 | 522424 | 0.234 | 0.044 | 0.073 | 0.006 | 415002016 | 30608834 | 37422882 | 9624470 | 1788687 | 87147515108 | 2525.990 | 346536202 | 10.044 | 499695.5 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34507415 | 520428951 | 83482576 | 158676520 | 22030098 | 11639538 | 0.021 | 0.144 | 0.204 | 0.091 | 19287934 | 3609226 | 6045313 | 521405 | 0.231 | 0.043 | 0.072 | 0.006 | 415152628 | 30610103 | 37407716 | 9641236 | 1794702 | 92759974976 | 2688.117 | 346780020 | 10.049 | 499783.6 | 162.127 | 0.005 | 32396.01 | 88.100 | +| S3b | 34499539 | 520396932 | 83618002 | 155590263 | 34428826 | 11625591 | 0.027 | 0.156 | 0.293 | 0.099 | 18988453 | 3564625 | 5980823 | 516662 | 0.227 | 0.043 | 0.072 | 0.006 | 414988556 | 30607762 | 37472866 | 9688489 | 1813970 | 96533122891 | 2798.099 | 346983955 | 10.058 | 500083.9 | 272.108 | 0.013 | 20598.68 | 388.391 | +| S3c | 34496334 | 520227370 | 83568351 | 157099275 | 28171361 | 11622564 | 0.024 | 0.150 | 0.249 | 0.095 | 19145218 | 3585036 | 6010150 | 518449 | 0.229 | 0.043 | 0.072 | 0.006 | 414875686 | 30589301 | 37479876 | 9661353 | 1804425 | 94096368027 | 2727.721 | 346758704 | 10.052 | 499874.5 | 201.730 | 0.008 | 26492.17 | 179.005 | +| S3d | 34507664 | 520495018 | 83555471 | 157877292 | 25364366 | 11630839 | 0.023 | 0.147 | 0.229 | 0.093 | 19209915 | 3595849 | 6028084 | 520340 | 0.230 | 0.043 | 0.072 | 0.006 | 415141325 | 30594930 | 37472224 | 9653084 | 1805226 | 94690116842 | 2744.031 | 346877136 | 10.052 | 499864.8 | 218.041 | 0.008 | 28147.56 | 169.277 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S1a | 37195779 | 78988588613 | 2123.590 | 415048183 | 11.158 | 17747.53 | 472.203 | -| S3b | 17248093 | 48252461324 | 2797.553 | 173460431 | 10.057 | 21108.54 | 369.460 | -| S2a | 22077788 | 55740228537 | 2524.720 | 241147117 | 10.923 | 18822.07 | 341.126 | -| S1b | 37200476 | 76461197768 | 2055.382 | 414832042 | 11.151 | 25820.11 | 179.457 | -| S3c | 17249568 | 47056539449 | 2727.984 | 173385532 | 10.052 | 26412.71 | 178.930 | -| S3d | 17250373 | 47356022542 | 2745.217 | 173385479 | 10.051 | 30588.27 | 138.090 | -| S3a | 17245589 | 46423704300 | 2691.918 | 173312928 | 10.050 | 28849.33 | 120.454 | -| S1c | 37192813 | 77318972106 | 2078.869 | 414653653 | 11.149 | 43696.51 | 31.032 | -| S1NoCD | 37196486 | 69325010796 | 1863.752 | 414511485 | 11.144 | NaN | 0.000 | -| S2NoCD | 22078563 | 51195392088 | 2318.783 | 240914015 | 10.912 | NaN | 0.000 | -| S3NoCD | 17243525 | 43585079096 | 2527.620 | 173193983 | 10.044 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S1a | 74380275 | 157886317266 | 2122.691 | 829882713 | 11.157 | 19821.86 | 393.003 | +| S3b | 34499539 | 96533122891 | 2798.099 | 346983955 | 10.058 | 20598.68 | 388.391 | +| S2a | 44164773 | 111527223359 | 2525.253 | 482358789 | 10.922 | 21423.74 | 271.695 | +| S3c | 34496334 | 94096368027 | 2727.721 | 346758704 | 10.052 | 26492.17 | 179.005 | +| S1b | 74383024 | 152914677120 | 2055.774 | 829494032 | 11.152 | 25892.74 | 178.033 | +| S3d | 34507664 | 94690116842 | 2744.031 | 346877136 | 10.052 | 28147.56 | 169.277 | +| S3a | 34507415 | 92759974976 | 2688.117 | 346780020 | 10.049 | 32396.01 | 88.100 | +| S1c | 74393892 | 154475292879 | 2076.451 | 829462690 | 11.150 | 39721.03 | 54.834 | +| S1NoCD | 74388747 | 138701936801 | 1864.555 | 829008490 | 11.144 | NaN | 0.000 | +| S2NoCD | 44156404 | 102511836117 | 2321.562 | 481847558 | 10.912 | NaN | 0.000 | +| S3NoCD | 34500334 | 87147515108 | 2525.990 | 346536202 | 10.044 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ---------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 69382514865 | 1865.269 | 0.000 | 1865.269 | 414538063 | 11.14438 | 0.00000 | 11.14438 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | -| S1a | 37195779 | 1.0000000 | 78988588613 | 2123.590 | 0.000 | 2123.590 | 415048183 | 11.15848 | 0.00000 | 11.15848 | 258.32106 | 0.0140966 | 18325.05 | 17747.53 | 446.509470 | -| S1b | 37200476 | 1.0000000 | 76461197768 | 2055.382 | 0.000 | 2055.382 | 414832042 | 11.15126 | 0.00000 | 11.15126 | 190.11318 | 0.0068775 | 27642.59 | 25820.11 | 153.764059 | -| S1c | 37192813 | 1.0000000 | 77318972106 | 2078.869 | 0.000 | 2078.869 | 414653653 | 11.14876 | 0.00000 | 11.14876 | 213.59957 | 0.0043788 | 48780.78 | 43696.51 | 5.338657 | -| S2NoCD | 22078563 | 0.5935568 | 51195392088 | 2318.783 | 1202.972 | 1865.269 | 240914015 | 10.91167 | 11.48422 | 11.14438 | 0.00000 | 0.0000000 | NaN | NaN | 0.007465 | -| S2a | 22077788 | 0.5935359 | 55740228537 | 2524.720 | 1202.972 | 1987.477 | 241147117 | 10.92261 | 11.48422 | 11.15088 | 122.20776 | 0.0065060 | 18783.98 | 18822.07 | 203.097484 | -| S3NoCD | 17243525 | 0.4635723 | 43585079096 | 2527.620 | 1292.876 | 1865.269 | 173193983 | 10.04400 | 12.09531 | 11.14438 | 0.00000 | 0.0000000 | NaN | NaN | 0.007465 | -| S3a | 17245589 | 0.4636278 | 46423704300 | 2691.918 | 1292.876 | 1941.511 | 173312928 | 10.04970 | 12.09531 | 11.14691 | 76.24143 | 0.0025265 | 30176.14 | 28849.33 | 50.093372 | -| S3b | 17248093 | 0.4636951 | 48252461324 | 2797.553 | 1292.876 | 1990.588 | 173460431 | 10.05679 | 12.09531 | 11.15006 | 125.31843 | 0.0056778 | 22071.79 | 21108.54 | 158.577220 | -| S3c | 17249568 | 0.4637348 | 47056539449 | 2727.984 | 1292.876 | 1958.385 | 173385532 | 10.05159 | 12.09531 | 11.14756 | 93.11618 | 0.0031846 | 29239.68 | 26412.71 | 66.120410 | -| S3d | 17250373 | 0.4637564 | 47356022542 | 2745.217 | 1292.876 | 1966.409 | 173385479 | 10.05111 | 12.09531 | 11.14730 | 101.13946 | 0.0029214 | 34620.20 | 30588.27 | 44.938003 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 138822291284 | 1866.177 | 0.000 | 1866.177 | 829028734 | 11.14457 | 0.00000 | 11.14457 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74380275 | 1.0000000 | 157886317266 | 2122.691 | 0.000 | 2122.691 | 829882713 | 11.15730 | 0.00000 | 11.15730 | 256.51338 | 0.0127265 | 20155.83 | 19821.86 | 379.81226 | +| S1b | 74383024 | 1.0000000 | 152914677120 | 2055.774 | 0.000 | 2055.774 | 829494032 | 11.15166 | 0.00000 | 11.15166 | 189.59656 | 0.0070888 | 26746.02 | 25892.74 | 164.84224 | +| S1c | 74393892 | 1.0000000 | 154475292879 | 2076.451 | 0.000 | 2076.451 | 829462690 | 11.14961 | 0.00000 | 11.14961 | 210.27398 | 0.0050384 | 41734.64 | 39721.03 | 41.64381 | +| S2NoCD | 44156404 | 0.5935911 | 102511836117 | 2321.562 | 1201.053 | 1866.177 | 481847558 | 10.91229 | 11.48383 | 11.14457 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44164773 | 0.5937036 | 111527223359 | 2525.253 | 1201.053 | 1987.235 | 482358789 | 10.92180 | 11.48383 | 11.15015 | 121.05803 | 0.0055805 | 21693.18 | 21423.74 | 157.96518 | +| S3NoCD | 34500334 | 0.4637853 | 87147515108 | 2525.990 | 1295.489 | 1866.177 | 346536202 | 10.04443 | 12.09611 | 11.14457 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34507415 | 0.4638805 | 92759974976 | 2688.117 | 1295.489 | 1941.502 | 346780020 | 10.04943 | 12.09611 | 11.14670 | 75.32455 | 0.0021262 | 35426.76 | 32396.01 | 30.98570 | +| S3b | 34499539 | 0.4637746 | 96533122891 | 2798.099 | 1295.489 | 1992.361 | 346983955 | 10.05764 | 12.09611 | 11.15072 | 126.18384 | 0.0061484 | 20523.09 | 20598.68 | 181.23543 | +| S3c | 34496334 | 0.4637315 | 94096368027 | 2727.721 | 1295.489 | 1959.660 | 346758704 | 10.05205 | 12.09611 | 11.14821 | 93.48255 | 0.0036415 | 25671.40 | 26492.17 | 88.59273 | +| S3d | 34507664 | 0.4638839 | 94690116842 | 2744.031 | 1295.489 | 1967.444 | 346877136 | 10.05218 | 12.09611 | 11.14796 | 101.26696 | 0.0033912 | 29861.30 | 28147.56 | 68.29524 | ![](../../outputs/Sen7_3_Discount_CEplot-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264130 | 0.1594355 | 0.3100498 | 0.0943012 | 0.4007333 | 0.0756571 | 0.1278762 | 0.0110774 | 0.8423964 | 0.0461075 | 0.0491633 | 0.0110600 | 0.0019303 | 0.4646262 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216055 | 0.1480604 | 0.2404960 | 0.0875941 | 0.4059903 | 0.0763713 | 0.1289378 | 0.0111722 | 0.8424281 | 0.0461201 | 0.0491384 | 0.0110451 | 0.0019244 | 0.3340531 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201493 | 0.1442413 | 0.2143855 | 0.0852093 | 0.4079480 | 0.0766531 | 0.1294892 | 0.0112077 | 0.8425382 | 0.0460584 | 0.0491005 | 0.0110280 | 0.0019282 | 0.2886177 | -| S2NoCD | 0.5935568 | 0.5823097 | 0.7053578 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935359 | 0.5824692 | 0.7062056 | 0.0223351 | 0.1468614 | 0.2290467 | 0.0868672 | 0.4071715 | 0.0764348 | 0.1292457 | 0.0111517 | 0.8425215 | 0.0460676 | 0.0490957 | 0.0110473 | 0.0019254 | 0.3104013 | -| S3NoCD | 0.4635723 | 0.4153676 | 0.5861997 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4636278 | 0.4155217 | 0.5874183 | 0.0201358 | 0.1392626 | 0.1805149 | 0.0822287 | 0.4109128 | 0.0771069 | 0.1301110 | 0.0112307 | 0.8424794 | 0.0461006 | 0.0491419 | 0.0110143 | 0.0019170 | 0.2306846 | -| S3b | 0.4636951 | 0.4155683 | 0.5872332 | 0.0226883 | 0.1466743 | 0.2326983 | 0.0870001 | 0.4064201 | 0.0764674 | 0.1291411 | 0.0111894 | 0.8425049 | 0.0460727 | 0.0491259 | 0.0110354 | 0.0019156 | 0.3174192 | -| S3c | 0.4637348 | 0.4155365 | 0.5876778 | 0.0213351 | 0.1429510 | 0.2072023 | 0.0845726 | 0.4084161 | 0.0768439 | 0.1295450 | 0.0111987 | 0.8424543 | 0.0461336 | 0.0491319 | 0.0110136 | 0.0019205 | 0.2739520 | -| S3d | 0.4637564 | 0.4156050 | 0.5875581 | 0.0207664 | 0.1413812 | 0.1952106 | 0.0835996 | 0.4094977 | 0.0769666 | 0.1297144 | 0.0112325 | 0.8424726 | 0.0461088 | 0.0491357 | 0.0110219 | 0.0019164 | 0.2543044 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0264033 | 0.1593018 | 0.3099946 | 0.0940914 | 0.4008461 | 0.0756315 | 0.1277333 | 0.0110873 | 0.8423642 | 0.0461290 | 0.0491766 | 0.0110496 | 0.0019359 | 0.4648330 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0216398 | 0.1482342 | 0.2406521 | 0.0877947 | 0.4059079 | 0.0764087 | 0.1290125 | 0.0111606 | 0.8424795 | 0.0460932 | 0.0491199 | 0.0110444 | 0.0019216 | 0.3342946 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0201517 | 0.1441110 | 0.2141912 | 0.0851720 | 0.4079678 | 0.0766467 | 0.1293303 | 0.0111361 | 0.8425119 | 0.0461015 | 0.0491018 | 0.0110241 | 0.0019174 | 0.2884076 | +| S2NoCD | 0.5935911 | 0.5823656 | 0.7051165 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5937036 | 0.5825616 | 0.7062500 | 0.0223572 | 0.1465203 | 0.2287835 | 0.0867962 | 0.4069072 | 0.0764858 | 0.1291620 | 0.0111850 | 0.8424534 | 0.0460995 | 0.0491621 | 0.0110233 | 0.0019191 | 0.3102030 | +| S3NoCD | 0.4637853 | 0.4155681 | 0.5866172 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4638805 | 0.4156993 | 0.5867088 | 0.0201156 | 0.1395918 | 0.1808230 | 0.0824771 | 0.4108939 | 0.0771596 | 0.1300215 | 0.0112568 | 0.8425660 | 0.0460728 | 0.0490892 | 0.0110179 | 0.0019129 | 0.2311946 | +| S3b | 0.4637746 | 0.4156737 | 0.5876605 | 0.0227032 | 0.1471017 | 0.2332507 | 0.0873282 | 0.4068980 | 0.0765657 | 0.1291642 | 0.0111939 | 0.8424573 | 0.0460719 | 0.0491421 | 0.0110558 | 0.0019283 | 0.3181560 | +| S3c | 0.4637315 | 0.4155383 | 0.5873116 | 0.0213262 | 0.1432680 | 0.2074859 | 0.0848645 | 0.4090175 | 0.0768424 | 0.1295624 | 0.0112182 | 0.8424856 | 0.0460621 | 0.0491521 | 0.0110349 | 0.0019208 | 0.2742435 | +| S3d | 0.4638839 | 0.4157521 | 0.5872211 | 0.0207546 | 0.1415673 | 0.1954816 | 0.0837051 | 0.4098442 | 0.0769796 | 0.1297896 | 0.0112424 | 0.8425108 | 0.0460587 | 0.0491390 | 0.0110271 | 0.0019212 | 0.2545329 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 14.43033 hours + ## Time difference of 1.217285 days diff --git a/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount5yrs.md b/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount5yrs.md index a67bbf9..8317157 100644 --- a/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount5yrs.md +++ b/reproduction/scripts/Sensitivity_Analysis/Sen7_3_Discount5yrs.md @@ -1,6 +1,6 @@ Sensitivity analysis: 3% Discount Rate ================ -15 October, 2024 +16 October, 2024 ## ## > errors<-c( @@ -144,14 +144,14 @@ All patients are eligible. The cost of case detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :-------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S1NoCD2 | 37196486 | 625953636 | 71118021 | 190966216 | 13166456 | 13371458 | 0.017 | 0.135 | 0.151 | 0.080 | 15396892 | 2883299 | 4850541 | 419077 | 0.216 | 0.041 | 0.068 | 0.006 | 527427474 | 28845970 | 30727603 | 6872520 | 1191666 | 69325010796 | 1863.752 | 414511485 | 11.144 | 555328.0 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCD | 37197623 | 626035666 | 71126460 | 124680042 | 13292032 | 16339249 | 0.021 | 0.135 | 0.151 | 0.080 | 15386115 | 2878926 | 4849649 | 418845 | 0.216 | 0.040 | 0.068 | 0.006 | 527498259 | 28860429 | 30702229 | 6887202 | 1198050 | 69440018935 | 1866.786 | 414564642 | 11.145 | 555379.4 | 0.000 | 0.000 | NaN | 0.000 | -| S1NoCDAvg | 37197054 | 625994651 | 71122240 | 157823129 | 13229244 | 14855354 | 0.019 | 0.135 | 0.151 | 0.080 | 15391504 | 2881112 | 4850095 | 418961 | 0.216 | 0.041 | 0.068 | 0.006 | 527462866 | 28853200 | 30714916 | 6879861 | 1194858 | 69382514865 | 1865.269 | 414538063 | 11.144 | 555353.7 | 0.000 | 0.000 | NaN | 0.000 | -| S1a | 37197502 | 626089853 | 71222084 | 122776626 | 28487983 | 16327137 | 0.028 | 0.154 | 0.273 | 0.091 | 14992350 | 2827989 | 4776515 | 413886 | 0.211 | 0.040 | 0.067 | 0.006 | 527456443 | 28870190 | 30752817 | 6907934 | 1206659 | 76233049354 | 2049.413 | 414888346 | 11.154 | 555633.7 | 182.627 | 0.009 | 20898.93 | 254.302 | -| S1b | 37190655 | 625992698 | 71214502 | 123717512 | 20974578 | 16327973 | 0.024 | 0.145 | 0.216 | 0.086 | 15197291 | 2852978 | 4811387 | 417126 | 0.213 | 0.040 | 0.068 | 0.006 | 527372066 | 28861102 | 30747408 | 6915037 | 1207305 | 74352383549 | 1999.222 | 414673206 | 11.150 | 555497.3 | 132.436 | 0.005 | 26448.85 | 117.926 | -| S1c | 37195162 | 626110982 | 71210037 | 124047387 | 18535585 | 16324587 | 0.023 | 0.142 | 0.196 | 0.084 | 15221449 | 2863867 | 4834566 | 417049 | 0.214 | 0.040 | 0.068 | 0.006 | 527490541 | 28868640 | 30764128 | 6896850 | 1196858 | 74927136726 | 2014.432 | 414704948 | 11.149 | 555457.2 | 147.646 | 0.005 | 32740.56 | 77.833 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :-------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | ---------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S1NoCD2 | 74388747 | 1251903576 | 142277086 | 381929878 | 26336153 | 26747209 | 0.017 | 0.135 | 0.151 | 0.080 | 30809289 | 5766720 | 9701609 | 839538.0 | 0.217 | 0.041 | 0.068 | 0.006 | 1054811684 | 57697202 | 61465410 | 13763906 | 2389153 | 138701936801 | 1864.555 | 829008490 | 11.144 | 555349.1 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCD | 74388425 | 1251968458 | 142302175 | 249329256 | 26636736 | 32661650 | 0.021 | 0.136 | 0.151 | 0.080 | 30801067 | 5759155 | 9700407 | 837363.0 | 0.216 | 0.040 | 0.068 | 0.006 | 1054852003 | 57672835 | 61488796 | 13791895 | 2388663 | 138942645767 | 1867.799 | 829048977 | 11.145 | 555375.5 | 0.000 | 0.000 | NaN | 0.000 | +| S1NoCDAvg | 74388586 | 1251936017 | 142289630 | 315629567 | 26486444 | 29704430 | 0.019 | 0.136 | 0.151 | 0.080 | 30805178 | 5762938 | 9701008 | 838450.5 | 0.216 | 0.041 | 0.068 | 0.006 | 1054831844 | 57685018 | 61477103 | 13777900 | 2388908 | 138822291284 | 1866.177 | 829028734 | 11.145 | 555362.3 | 0.000 | 0.000 | NaN | 0.000 | +| S1a | 74386318 | 1252092577 | 142511621 | 245523949 | 57058349 | 32655914 | 0.028 | 0.154 | 0.274 | 0.091 | 30028808 | 5656584 | 9558038 | 827432.0 | 0.211 | 0.040 | 0.067 | 0.006 | 1054768469 | 57752767 | 61521629 | 13851433 | 2413714 | 152526962185 | 2050.471 | 829711078 | 11.154 | 555653.6 | 182.671 | 0.009 | 19819.98 | 278.155 | +| S1b | 74385413 | 1252007176 | 142455061 | 247448362 | 41936466 | 32651747 | 0.024 | 0.145 | 0.216 | 0.086 | 30368698 | 5706469 | 9627370 | 832514.0 | 0.213 | 0.040 | 0.068 | 0.006 | 1054746061 | 57768304 | 61498391 | 13812986 | 2404656 | 148706489801 | 1999.135 | 829367944 | 11.150 | 555481.1 | 131.336 | 0.005 | 27712.02 | 105.630 | +| S1c | 74390720 | 1252048091 | 142295860 | 248074520 | 37009576 | 32668233 | 0.023 | 0.142 | 0.196 | 0.084 | 30456632 | 5715293 | 9646702 | 833108.0 | 0.214 | 0.040 | 0.068 | 0.006 | 1054933501 | 57690667 | 61453687 | 13794504 | 2396041 | 149630762735 | 2011.417 | 829312433 | 11.148 | 555391.7 | 143.618 | 0.003 | 44912.99 | 16.267 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -195,10 +195,10 @@ detection is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S2NoCD | 22074342 | 364499893 | 50179989 | 72492409 | 9769650 | 9434235 | 0.021 | 0.142 | 0.160 | 0.087 | 11472370 | 2126666 | 3551252 | 304704 | 0.229 | 0.042 | 0.071 | 0.006 | 298757005 | 18626945 | 22501053 | 5562438 | 1027303 | 51361753549 | 2326.763 | 240891916 | 10.913 | 543311.1 | 0.00 | 0.000 | NaN | 0.000 | -| S2a | 22077777 | 364514086 | 50214779 | 71673455 | 16290550 | 9435494 | 0.025 | 0.153 | 0.241 | 0.095 | 11245330 | 2100490 | 3507989 | 302346 | 0.224 | 0.042 | 0.070 | 0.006 | 298734836 | 18629376 | 22530917 | 5562183 | 1028646 | 54432158311 | 2465.473 | 241039404 | 10.918 | 543421.5 | 138.71 | 0.005 | 27839.41 | 110.415 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | --------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | -------: | ------: | -----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S2NoCD | 44157029 | 729047563 | 100380900 | 145000421 | 19524492 | 18863743 | 0.021 | 0.142 | 0.160 | 0.087 | 22925265 | 4254784 | 7099566 | 609563 | 0.228 | 0.042 | 0.071 | 0.006 | 597538799 | 37245010 | 45040554 | 11117169 | 2054803 | 102687192587 | 2325.500 | 481821543 | 10.912 | 543251.9 | 0.000 | 0.000 | NaN | 0.0 | +| S2a | 44154576 | 729145856 | 100448839 | 143361789 | 32595478 | 18878233 | 0.025 | 0.154 | 0.242 | 0.095 | 22519648 | 4200194 | 7025459 | 605531 | 0.224 | 0.042 | 0.070 | 0.006 | 597564735 | 37286040 | 45033303 | 11135908 | 2066352 | 108994087698 | 2468.466 | 482147541 | 10.920 | 543508.4 | 142.966 | 0.008 | 17894.65 | 256.5 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -278,13 +278,13 @@ is: ## [1] 0 -| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | -| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | ------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | -----: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | -| S3NoCD | 17254548 | 260185517 | 41753987 | 52456874 | 7922835 | 7061036 | 0.022 | 0.137 | 0.155 | 0.086 | 9767617 | 1818208 | 3040076 | 262205 | 0.234 | 0.044 | 0.073 | 0.006 | 207533583 | 15301679 | 18724752 | 4815426 | 897482 | 43698225565 | 2532.563 | 173302716 | 10.044 | 499661.7 | 0.000 | 0.000 | NaN | 0.000 | -| S3a | 17251608 | 260177738 | 41735217 | 52193377 | 10112286 | 7056308 | 0.024 | 0.142 | 0.189 | 0.089 | 9673981 | 1809610 | 3026757 | 259927 | 0.232 | 0.043 | 0.073 | 0.006 | 207543323 | 15307443 | 18697708 | 4818609 | 897810 | 45514928490 | 2638.301 | 173345068 | 10.048 | 499764.3 | 105.738 | 0.004 | 25377.33 | 102.594 | -| S3b | 17246874 | 260180750 | 41770771 | 51592135 | 14901907 | 7060341 | 0.029 | 0.152 | 0.258 | 0.096 | 9537491 | 1786791 | 3000373 | 258790 | 0.228 | 0.043 | 0.072 | 0.006 | 207513062 | 15306657 | 18723252 | 4827550 | 898750 | 46894607075 | 2719.021 | 173436965 | 10.056 | 500087.9 | 186.458 | 0.012 | 15217.32 | 426.192 | -| S3c | 17246125 | 260144350 | 41792942 | 51894923 | 12432863 | 7060467 | 0.026 | 0.147 | 0.223 | 0.093 | 9621451 | 1801612 | 3014035 | 259735 | 0.230 | 0.043 | 0.072 | 0.006 | 207459068 | 15294280 | 18748666 | 4834049 | 901039 | 46057749843 | 2670.614 | 173359597 | 10.052 | 499933.9 | 138.052 | 0.008 | 16828.15 | 272.129 | -| S3d | 17255729 | 260233694 | 41777900 | 52047317 | 11356970 | 7062160 | 0.025 | 0.144 | 0.207 | 0.091 | 9643777 | 1802264 | 3018596 | 260225 | 0.231 | 0.043 | 0.072 | 0.006 | 207557193 | 15328896 | 18715546 | 4823282 | 894293 | 46194581774 | 2677.058 | 173405973 | 10.049 | 499782.1 | 144.495 | 0.005 | 27281.08 | 120.331 | +| Scenario | Agents | PatientYears | CopdPYs | NCaseDetections | DiagnosedPYs | OverdiagnosedPYs | SABA | LAMA | LAMALABA | ICSLAMALABA | Mild | Moderate | Severe | VerySevere | MildPY | ModeratePY | SeverePY | VerySeverePY | NoCOPD | GOLD1 | GOLD2 | GOLD3 | GOLD4 | Cost | CostpAgent | QALY | QALYpAgent | NMB | IncrementalCosts | IncrementalQALY | ICER | IncrementalNMB | +| :------- | -------: | -----------: | -------: | --------------: | -----------: | ---------------: | ----: | ----: | -------: | ----------: | -------: | -------: | ------: | ---------: | -----: | ---------: | -------: | -----------: | --------: | -------: | -------: | ------: | ------: | ----------: | ---------: | --------: | ---------: | -------: | ---------------: | --------------: | -------: | -------------: | +| S3NoCD | 34491937 | 520096794 | 83394436 | 104866546 | 15798844 | 14116443 | 0.022 | 0.137 | 0.154 | 0.086 | 19479590 | 3630576 | 6075819 | 523166 | 0.234 | 0.044 | 0.073 | 0.006 | 414917152 | 30599570 | 37365292 | 9614469 | 1790750 | 87288548274 | 2530.694 | 346433081 | 10.044 | 499663.6 | 0.000 | 0.000 | NaN | 0.000 | +| S3a | 34494037 | 520214111 | 83457293 | 104351592 | 20245608 | 14129448 | 0.024 | 0.142 | 0.189 | 0.089 | 19332282 | 3614629 | 6055063 | 518761 | 0.232 | 0.043 | 0.073 | 0.006 | 414968911 | 30599997 | 37426814 | 9615582 | 1787056 | 91012637190 | 2638.503 | 346595429 | 10.048 | 499760.5 | 107.809 | 0.004 | 26326.46 | 96.945 | +| S3b | 34509196 | 520537138 | 83620081 | 103218767 | 29823148 | 14132996 | 0.029 | 0.152 | 0.258 | 0.096 | 19135380 | 3582069 | 6004729 | 516649 | 0.229 | 0.043 | 0.072 | 0.006 | 415119150 | 30640730 | 37483240 | 9661621 | 1802895 | 93844195380 | 2719.397 | 346989244 | 10.055 | 500029.6 | 188.702 | 0.011 | 17010.73 | 365.955 | +| S3c | 34504471 | 520423616 | 83513343 | 103824096 | 24853847 | 14121585 | 0.026 | 0.146 | 0.223 | 0.093 | 19220385 | 3595075 | 6024956 | 518536 | 0.230 | 0.043 | 0.072 | 0.006 | 415113845 | 30619979 | 37421385 | 9639642 | 1802009 | 92029481714 | 2667.176 | 346825427 | 10.052 | 499913.2 | 136.481 | 0.008 | 17673.54 | 249.636 | +| S3d | 34501231 | 520389346 | 83507084 | 104079260 | 22711874 | 14135933 | 0.025 | 0.144 | 0.207 | 0.091 | 19266710 | 3605577 | 6035420 | 519637 | 0.231 | 0.043 | 0.072 | 0.006 | 415086795 | 30631737 | 37413709 | 9638221 | 1794998 | 92355832428 | 2676.885 | 346759011 | 10.051 | 499854.5 | 146.191 | 0.007 | 21685.99 | 190.872 | *Treatment rate:* SABA is expressed per all patient-years, LAMA, LAMA/LABA, ICS/LAMA/LABA are per COPD patient-years *Exacerbations:* @@ -299,19 +299,19 @@ per patient-year *Ordered by descending Net Monetary Benefit* -| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | -| :------- | -------: | ----------: | ---------: | --------: | ---------: | -------: | -------------: | -| S3b | 17246874 | 46894607075 | 2719.021 | 173436965 | 10.056 | 15217.32 | 426.192 | -| S3c | 17246125 | 46057749843 | 2670.614 | 173359597 | 10.052 | 16828.15 | 272.129 | -| S1a | 37197502 | 76233049354 | 2049.413 | 414888346 | 11.154 | 20898.93 | 254.302 | -| S3d | 17255729 | 46194581774 | 2677.058 | 173405973 | 10.049 | 27281.08 | 120.331 | -| S1b | 37190655 | 74352383549 | 1999.222 | 414673206 | 11.150 | 26448.85 | 117.926 | -| S2a | 22077777 | 54432158311 | 2465.473 | 241039404 | 10.918 | 27839.41 | 110.415 | -| S3a | 17251608 | 45514928490 | 2638.301 | 173345068 | 10.048 | 25377.33 | 102.594 | -| S1c | 37195162 | 74927136726 | 2014.432 | 414704948 | 11.149 | 32740.56 | 77.833 | -| S1NoCD | 37197623 | 69440018935 | 1866.786 | 414564642 | 11.145 | NaN | 0.000 | -| S2NoCD | 22074342 | 51361753549 | 2326.763 | 240891916 | 10.913 | NaN | 0.000 | -| S3NoCD | 17254548 | 43698225565 | 2532.563 | 173302716 | 10.044 | NaN | 0.000 | +| Scenario | Agents | Cost | CostpAgent | QALY | QALYpAgent | ICER | IncrementalNMB | +| :------- | -------: | -----------: | ---------: | --------: | ---------: | -------: | -------------: | +| S3b | 34509196 | 93844195380 | 2719.397 | 346989244 | 10.055 | 17010.73 | 365.955 | +| S1a | 74386318 | 152526962185 | 2050.471 | 829711078 | 11.154 | 19819.98 | 278.155 | +| S2a | 44154576 | 108994087698 | 2468.466 | 482147541 | 10.920 | 17894.65 | 256.500 | +| S3c | 34504471 | 92029481714 | 2667.176 | 346825427 | 10.052 | 17673.54 | 249.636 | +| S3d | 34501231 | 92355832428 | 2676.885 | 346759011 | 10.051 | 21685.99 | 190.872 | +| S1b | 74385413 | 148706489801 | 1999.135 | 829367944 | 11.150 | 27712.02 | 105.630 | +| S3a | 34494037 | 91012637190 | 2638.503 | 346595429 | 10.048 | 26326.46 | 96.945 | +| S1c | 74390720 | 149630762735 | 2011.417 | 829312433 | 11.148 | 44912.99 | 16.267 | +| S1NoCD | 74388425 | 138942645767 | 1867.799 | 829048977 | 11.145 | NaN | 0.000 | +| S2NoCD | 44157029 | 102687192587 | 2325.500 | 481821543 | 10.912 | NaN | 0.000 | +| S3NoCD | 34491937 | 87288548274 | 2530.694 | 346433081 | 10.044 | NaN | 0.000 | ----- @@ -319,19 +319,19 @@ per patient-year Adjusted to the total population -| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | -| :-------- | -------: | ---------: | ----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | ---------: | -| S1NoCDAvg | 37197054 | 1.0000000 | 69382514865 | 1865.269 | 0.000 | 1865.269 | 414538063 | 11.14438 | 0.00000 | 11.14438 | 0.00000 | 0.0000000 | NaN | NaN | 0.000000 | -| S1a | 37197502 | 1.0000000 | 76233049354 | 2049.413 | 0.000 | 2049.413 | 414888346 | 11.15366 | 0.00000 | 11.15366 | 184.14408 | 0.0092828 | 19837.20 | 20898.93 | 279.994104 | -| S1b | 37190655 | 1.0000000 | 74352383549 | 1999.222 | 0.000 | 1999.222 | 414673206 | 11.14993 | 0.00000 | 11.14993 | 133.95315 | 0.0055514 | 24129.44 | 26448.85 | 143.618822 | -| S1c | 37195162 | 1.0000000 | 74927136726 | 2014.432 | 0.000 | 2014.432 | 414704948 | 11.14943 | 0.00000 | 11.14943 | 149.16327 | 0.0050538 | 29515.25 | 32740.56 | 103.525173 | -| S2NoCD | 22074342 | 0.5934433 | 51361753549 | 2326.763 | 1191.636 | 1865.269 | 240891916 | 10.91276 | 11.48247 | 11.14438 | 0.00000 | 0.0000000 | NaN | NaN | 0.007465 | -| S2a | 22077777 | 0.5935356 | 54432158311 | 2465.473 | 1191.636 | 1947.703 | 241039404 | 10.91774 | 11.48247 | 11.14728 | 82.43426 | 0.0029047 | 28379.74 | 27839.41 | 62.807570 | -| S3NoCD | 17254548 | 0.4638687 | 43698225565 | 2532.563 | 1287.917 | 1865.269 | 173302716 | 10.04389 | 12.09654 | 11.14438 | 0.00000 | 0.0000000 | NaN | NaN | 0.007465 | -| S3a | 17251608 | 0.4637896 | 45514928490 | 2638.301 | 1287.917 | 1914.211 | 173345068 | 10.04805 | 12.09654 | 11.14647 | 48.94176 | 0.0020947 | 23364.81 | 25377.33 | 55.799601 | -| S3b | 17246874 | 0.4636624 | 46894607075 | 2719.021 | 1287.917 | 1951.466 | 173436965 | 10.05614 | 12.09654 | 11.15048 | 86.19675 | 0.0061047 | 14119.66 | 15217.32 | 219.047390 | -| S3c | 17246125 | 0.4636422 | 46057749843 | 2670.614 | 1287.917 | 1928.994 | 173359597 | 10.05209 | 12.09654 | 11.14865 | 63.72473 | 0.0042684 | 14929.59 | 16828.15 | 149.700313 | -| S3d | 17255729 | 0.4639004 | 46194581774 | 2677.058 | 1287.917 | 1932.340 | 173405973 | 10.04918 | 12.09654 | 11.14677 | 67.07077 | 0.0023919 | 28040.92 | 27281.08 | 52.531138 | +| Scenario | Agents | PropAgents | Cost | CostpAgent | CostpAgentExcluded | CostpAgentAll | QALY | QALYpAgent | QALYpAgentExcluded | QALYpAgentAll | IncrementalCosts | IncrementalQALY | ICERAdj | ICER | INMB | +| :-------- | -------: | ---------: | -----------: | ---------: | -----------------: | ------------: | --------: | ---------: | -----------------: | ------------: | ---------------: | --------------: | -------: | -------: | --------: | +| S1NoCDAvg | 74388586 | 1.0000000 | 138822291284 | 1866.177 | 0.000 | 1866.177 | 829028734 | 11.14457 | 0.00000 | 11.14457 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S1a | 74386318 | 1.0000000 | 152526962185 | 2050.471 | 0.000 | 2050.471 | 829711078 | 11.15408 | 0.00000 | 11.15408 | 184.29335 | 0.0095128 | 19373.25 | 19819.98 | 291.34545 | +| S1b | 74385413 | 1.0000000 | 148706489801 | 1999.135 | 0.000 | 1999.135 | 829367944 | 11.14960 | 0.00000 | 11.14960 | 132.95779 | 0.0050356 | 26403.79 | 27712.02 | 118.82008 | +| S1c | 74390720 | 1.0000000 | 149630762735 | 2011.417 | 0.000 | 2011.417 | 829312433 | 11.14806 | 0.00000 | 11.14806 | 145.23974 | 0.0034939 | 41569.07 | 44912.99 | 29.45715 | +| S2NoCD | 44157029 | 0.5935995 | 102687192587 | 2325.500 | 1195.277 | 1866.177 | 481821543 | 10.91155 | 11.48493 | 11.14457 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S2a | 44154576 | 0.5935665 | 108994087698 | 2468.466 | 1195.277 | 1951.000 | 482147541 | 10.91954 | 11.48493 | 11.14933 | 84.82252 | 0.0047611 | 17815.76 | 17894.65 | 153.23220 | +| S3NoCD | 34491937 | 0.4636724 | 87288548274 | 2530.694 | 1291.681 | 1866.177 | 346433081 | 10.04389 | 12.09614 | 11.14457 | 0.00000 | 0.0000000 | NaN | NaN | 0.00000 | +| S3a | 34494037 | 0.4637007 | 91012637190 | 2638.503 | 1291.681 | 1916.203 | 346595429 | 10.04798 | 12.09614 | 11.14641 | 50.02617 | 0.0018410 | 27173.96 | 26326.46 | 42.02184 | +| S3b | 34509196 | 0.4639044 | 93844195380 | 2719.397 | 1291.681 | 1954.005 | 346989244 | 10.05498 | 12.09614 | 11.14924 | 87.82737 | 0.0046700 | 18806.67 | 17010.73 | 145.67317 | +| S3c | 34504471 | 0.4638409 | 92029481714 | 2667.176 | 1291.681 | 1929.692 | 346825427 | 10.05161 | 12.09614 | 11.14781 | 63.51436 | 0.0032361 | 19626.52 | 17673.54 | 98.29313 | +| S3d | 34501231 | 0.4637974 | 92355832428 | 2676.885 | 1291.681 | 1934.135 | 346759011 | 10.05063 | 12.09614 | 11.14744 | 67.95773 | 0.0028702 | 23677.23 | 21685.99 | 75.55086 | ![](../../outputs/Sen7_3_Discount_CEplot_5y-1.png) @@ -341,17 +341,17 @@ Adjusted to the total population | Scenario | PropAgents | ProppPatientYears | ProppCopdPYs | SABAAll | LAMAAll | LAMALABAAll | ICSLAMALABAAll | MildpAgentAll | ModeratepAgentAll | SeverepAgentAll | VerySeverepAgentAll | NoCOPDpPYAll | GOLD1pPYAll | GOLD2pPYAll | GOLD3pPYAll | GOLD4pPYAll | DiagnosedpPYAll | | :-------- | ---------: | ----------------: | -----------: | --------: | --------: | ----------: | -------------: | ------------: | ----------------: | --------------: | ------------------: | -----------: | ----------: | ----------: | ----------: | ----------: | --------------: | -| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277801 | 0.1541410 | 0.2732173 | 0.0911566 | 0.4030472 | 0.0760263 | 0.1284096 | 0.0111267 | 0.8424613 | 0.0461119 | 0.0491189 | 0.0110335 | 0.0019273 | 0.3999881 | -| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240553 | 0.1447802 | 0.2157515 | 0.0856247 | 0.4086320 | 0.0767122 | 0.1293709 | 0.0112159 | 0.8424572 | 0.0461045 | 0.0491178 | 0.0110465 | 0.0019286 | 0.2945268 | -| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229349 | 0.1422163 | 0.1962587 | 0.0839634 | 0.4092320 | 0.0769957 | 0.1299784 | 0.0112125 | 0.8424873 | 0.0461079 | 0.0491353 | 0.0110154 | 0.0019116 | 0.2602946 | -| S2NoCD | 0.5934433 | 0.5822732 | 0.7055457 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S2a | 0.5935356 | 0.5822958 | 0.7060348 | 0.0214261 | 0.1433997 | 0.2089133 | 0.0847853 | 0.4076552 | 0.0767471 | 0.1292182 | 0.0111992 | 0.8425444 | 0.0460948 | 0.0491128 | 0.0109898 | 0.0019109 | 0.2776121 | -| S3NoCD | 0.4638687 | 0.4156354 | 0.5870736 | 0.0190088 | 0.1354718 | 0.1512902 | 0.0796021 | 0.4137829 | 0.0774554 | 0.1303892 | 0.0112633 | 0.8425996 | 0.0460918 | 0.0490658 | 0.0109903 | 0.0019087 | 0.1860071 | -| S3a | 0.4637896 | 0.4156229 | 0.5868096 | 0.0197697 | 0.1380286 | 0.1714296 | 0.0812364 | 0.4112879 | 0.0772285 | 0.1300383 | 0.0112027 | 0.8426261 | 0.0461014 | 0.0490230 | 0.0109954 | 0.0019093 | 0.2168391 | -| S3b | 0.4636624 | 0.4156278 | 0.5873096 | 0.0217273 | 0.1440757 | 0.2123156 | 0.0853238 | 0.4076544 | 0.0766218 | 0.1293406 | 0.0111731 | 0.8425735 | 0.0461000 | 0.0490636 | 0.0110097 | 0.0019108 | 0.2840923 | -| S3c | 0.4636422 | 0.4155696 | 0.5876213 | 0.0206711 | 0.1409315 | 0.1917630 | 0.0832429 | 0.4099172 | 0.0770213 | 0.1297097 | 0.0111987 | 0.8425381 | 0.0460824 | 0.0491061 | 0.0110204 | 0.0019145 | 0.2493205 | -| S3d | 0.4639004 | 0.4157123 | 0.5874098 | 0.0202417 | 0.1395900 | 0.1822885 | 0.0822922 | 0.4104446 | 0.0770251 | 0.1298089 | 0.0112098 | 0.8425700 | 0.0461324 | 0.0490486 | 0.0110024 | 0.0019036 | 0.2342313 | +| S1NoCDAvg | 1.0000000 | 1.0000000 | 1.0000000 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S1a | 1.0000000 | 1.0000000 | 1.0000000 | 0.0277770 | 0.1541676 | 0.2735725 | 0.0911068 | 0.4036872 | 0.0760433 | 0.1284919 | 0.0111234 | 0.8424045 | 0.0461250 | 0.0491350 | 0.0110626 | 0.0019277 | 0.4003768 | +| S1b | 1.0000000 | 1.0000000 | 1.0000000 | 0.0240246 | 0.1449184 | 0.2159908 | 0.0856256 | 0.4082615 | 0.0767149 | 0.1294255 | 0.0111919 | 0.8424441 | 0.0461406 | 0.0491198 | 0.0110327 | 0.0019206 | 0.2943838 | +| S1c | 1.0000000 | 1.0000000 | 1.0000000 | 0.0229387 | 0.1419011 | 0.1959119 | 0.0838224 | 0.4094144 | 0.0768280 | 0.1296761 | 0.0111991 | 0.8425663 | 0.0460770 | 0.0490825 | 0.0110176 | 0.0019137 | 0.2600889 | +| S2NoCD | 0.5935995 | 0.5823361 | 0.7054688 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S2a | 0.5935665 | 0.5824146 | 0.7059463 | 0.0213966 | 0.1438505 | 0.2094804 | 0.0850851 | 0.4086675 | 0.0767385 | 0.1294165 | 0.0112173 | 0.8425126 | 0.0461064 | 0.0490974 | 0.0110198 | 0.0019173 | 0.2779271 | +| S3NoCD | 0.4636724 | 0.4154340 | 0.5860893 | 0.0190054 | 0.1355252 | 0.1513708 | 0.0796683 | 0.4141116 | 0.0774707 | 0.1304099 | 0.0112712 | 0.8425605 | 0.0460767 | 0.0491056 | 0.0110053 | 0.0019082 | 0.1861446 | +| S3a | 0.4637007 | 0.4155277 | 0.5865311 | 0.0197899 | 0.1383033 | 0.1717111 | 0.0814794 | 0.4121234 | 0.0772548 | 0.1301283 | 0.0112118 | 0.8425199 | 0.0460735 | 0.0491517 | 0.0110056 | 0.0019051 | 0.2173159 | +| S3b | 0.4639044 | 0.4157857 | 0.5876752 | 0.0217416 | 0.1441790 | 0.2124183 | 0.0853294 | 0.4094186 | 0.0768062 | 0.1294332 | 0.0111818 | 0.8424143 | 0.0460965 | 0.0491883 | 0.0110409 | 0.0019176 | 0.2844185 | +| S3c | 0.4638409 | 0.4156951 | 0.5869250 | 0.0206754 | 0.1410634 | 0.1917068 | 0.0833411 | 0.4105793 | 0.0769845 | 0.1297108 | 0.0112077 | 0.8424894 | 0.0460833 | 0.0491418 | 0.0110239 | 0.0019170 | 0.2496308 | +| S3d | 0.4637974 | 0.4156677 | 0.5868810 | 0.0202585 | 0.1397122 | 0.1824904 | 0.0824625 | 0.4112144 | 0.0771280 | 0.1298555 | 0.0112228 | 0.8424917 | 0.0460937 | 0.0491366 | 0.0110229 | 0.0019114 | 0.2345851 | ## Time elapsed @@ -363,4 +363,4 @@ time.taken <- end.time - start.time time.taken ``` - ## Time difference of 14.04066 hours + ## Time difference of 1.276366 days