diff --git a/pybind11/setup_helpers.py b/pybind11/setup_helpers.py
index f24291818c..c36c186db7 100644
--- a/pybind11/setup_helpers.py
+++ b/pybind11/setup_helpers.py
@@ -149,7 +149,7 @@ def __init__(self, *args: Any, **kwargs: Any) -> None:
         if WIN:
             cflags += ["/EHsc", "/bigobj"]
         else:
-            cflags += ["-fvisibility=hidden"]
+            cflags += ["-fvisibility=hidden", "-Wno-gnu-zero-variadic-macro-arguments"]
             env_cflags = os.environ.get("CFLAGS", "")
             env_cppflags = os.environ.get("CPPFLAGS", "")
             c_cpp_flags = shlex.split(env_cflags) + shlex.split(env_cppflags)
diff --git a/tests/CMakeLists.txt b/tests/CMakeLists.txt
index 01b6c0a3e6..779adbc9cf 100644
--- a/tests/CMakeLists.txt
+++ b/tests/CMakeLists.txt
@@ -389,6 +389,9 @@ function(pybind11_enable_warnings target_name)
     if(DEFINED CMAKE_CXX_STANDARD AND NOT CMAKE_CXX_STANDARD VERSION_LESS 20)
       target_compile_options(${target_name} PRIVATE -Wpedantic)
     endif()
+    if(CMAKE_CXX_COMPILER_ID MATCHES "Clang")
+      target_compile_options(${target_name} PRIVATE -Wno-gnu-zero-variadic-macro-arguments)
+    endif()
   endif()
 
   if(PYBIND11_WERROR)