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make_lift should recognize PGC I/D variants #27

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ofrei opened this issue Apr 26, 2018 · 1 comment
Open

make_lift should recognize PGC I/D variants #27

ofrei opened this issue Apr 26, 2018 · 1 comment

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@ofrei
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ofrei commented Apr 26, 2018

1kG:

1       rs57589734      0       39741584        G       GCTT
1       rs71906760      0       39698705        GTTTTGTT        G
1       rs67966942      0       39711950        AAAGTT  A

PGC_SCZ_2014:

D       I8      39698705        1       chr1_39698705_D
D       I3      39707474        1       chr1_39707474_D
D       I6      39711950        1       chr1_39711950_D
D       I3      39714273        1       chr1_39714273_I
I2      D       39715857        1       chr1_39715857_I
I2      D       39716844        1       chr1_39716844_I
I2      D       39733604        1       chr1_39733604_D
I5      D       39736463        1       chr1_39736463_I
D       I4      39741584        1       chr1_39741584_I
I2      D       39742864        1       chr1_39742864_D
@ofrei
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ofrei commented Apr 26, 2018

I think solution is to lift PGC summary stats by

  • lookup each D/I variant from PGC in the reference (e.i. add --ref param to sumstats.py lift)
  • replacing A1/A2 from D/I codes to the actual allele codes
  • replacing marker names with the actual rs#

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