Genome-Wide Association Study Approach for Predicting Brain Disorders

[Remi-Gau]

Submitted by Samar S. M. Elsheikh*

Genetic variations affect the susceptibility of complex diseases including brain disorders. The availability of both genetic patient's information and brain images provides the researcher with more opportunities to propose models and pipelines that allows integrating imaging and genetic information. However, researchers have to deal with many issues in this context:

• Analyzing two heterogeneous datasets
• Existence of co-linearity within each dataset
• A need for a huge number of samples

Suggested solutions:

Using the following graph as a construct, in a Structural Equation Model settings.