diff --git a/cl-base.owl b/cl-base.owl
index 00ed838d4..b9c675cc4 100644
--- a/cl-base.owl
+++ b/cl-base.owl
@@ -17,7 +17,7 @@
xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
-
+
An ontology of cell types.
Cell Ontology
@@ -33,7 +33,7 @@
See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo.
- 2023-09-21
+ 2023-10-19
@@ -133,17 +133,6 @@
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -467,9 +456,9 @@
-
+
-
+
@@ -1496,7 +1485,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
mature oocyte
ovum
egg cell
- https://www.swissbiopics.org/api/image/Egg_cell.svg
+ https://www.swissbiopics.org/api/image/Egg_cell.svg
@@ -1922,7 +1911,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
HSC
-
+
@@ -1966,13 +1955,13 @@ Covers cells actively being cultured or stored in a quiescent state for future u
BFU-E
-
+
CFU-E
-
+
@@ -2069,7 +2058,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
CFU-M
-
+
@@ -2473,21 +2462,21 @@ Covers cells actively being cultured or stored in a quiescent state for future u
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -2626,13 +2615,13 @@ Covers cells actively being cultured or stored in a quiescent state for future u
CLP
-
+
ELP
-
+
@@ -3063,7 +3052,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -3398,10 +3387,8 @@ Covers cells actively being cultured or stored in a quiescent state for future u
An epithelial cell of the lung.
-
BTO:0004299
lung epithelial cell
-
epithelial cell of lung
@@ -4447,7 +4434,9 @@ Covers cells actively being cultured or stored in a quiescent state for future u
A vertebrate phagocyte with a single nucleus.
+
BTO:0001433
+
mononuclear phagocyte
@@ -4717,6 +4706,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
+
BTO:0002606
CALOHA:TS-0415
FMA:54536
@@ -4724,6 +4714,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
neuroglial cell
neuroglia
+
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
glial cell
@@ -5111,20 +5102,20 @@ Covers cells actively being cultured or stored in a quiescent state for future u
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -5460,7 +5451,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
APC
-
+
@@ -5584,10 +5575,8 @@ Covers cells actively being cultured or stored in a quiescent state for future u
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -6677,7 +6666,7 @@ The modern definition of neurosecretion has evolved to include the release of an
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -7233,7 +7222,7 @@ The modern definition of neurosecretion has evolved to include the release of an
CALOHA:TS-0868
FMA:86740
photoreceptor cell
- https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
+ https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
@@ -9089,10 +9078,8 @@ The modern definition of neurosecretion has evolved to include the release of an
An epithelial cell found in the trachea.
-
FMA:74793
tracheocyte
-
This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
tracheal epithelial cell
@@ -11193,6 +11180,8 @@ The modern definition of neurosecretion has evolved to include the release of an
A cell whose nucleus contains a single haploid genome.
+
+
haploid cell
@@ -13690,7 +13679,7 @@ The modern definition of neurosecretion has evolved to include the release of an
-
+
A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.
@@ -14010,7 +13999,7 @@ The modern definition of neurosecretion has evolved to include the release of an
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -14417,7 +14406,7 @@ The modern definition of neurosecretion has evolved to include the release of an
https://github.com/obophenotype/cell-ontology/issues/2124
obsolete animal cell
true
- https://www.swissbiopics.org/api/image/Animal_cells.svg
+ https://www.swissbiopics.org/api/image/Animal_cells.svg
@@ -14993,7 +14982,7 @@ The modern definition of neurosecretion has evolved to include the release of an
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -15002,7 +14991,7 @@ The modern definition of neurosecretion has evolved to include the release of an
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -15292,15 +15281,15 @@ The modern definition of neurosecretion has evolved to include the release of an
AC
doi:10.1038/s41598-020-66092-9
-
+
ACs
doi:10.1038/s41598-020-66092-9
+
-
@@ -15484,10 +15473,8 @@ The modern definition of neurosecretion has evolved to include the release of an
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -16612,7 +16599,7 @@ The modern definition of neurosecretion has evolved to include the release of an
RBC
-
+
@@ -17046,7 +17033,7 @@ The modern definition of neurosecretion has evolved to include the release of an
CFU-Eo
-
+
@@ -17054,7 +17041,7 @@ The modern definition of neurosecretion has evolved to include the release of an
EoP
PMCID:PMC2212039
PMCID:PMC2626675
-
+
@@ -18113,14 +18100,14 @@ The modern definition of neurosecretion has evolved to include the release of an
FS cell
PMID:34734454
-
+
FSC
doi:10.23937/2572-407X.1510006
-
+
@@ -19683,10 +19670,12 @@ radial glial cells acting as neural progenitors throughout life.
Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord.
+
2023-08-04T08:48:30Z
choroid plexus cell
FMA:70549
epithelial cell of choroid plexus
+
choroid plexus epithelial cell
@@ -20364,15 +20353,15 @@ radial glial cells acting as neural progenitors throughout life.
RGC
doi:10.1038/s41598-020-66092-9
-
+
RGCs
doi:10.1038/s41598-020-66092-9
+
-
@@ -20427,6 +20416,8 @@ radial glial cells acting as neural progenitors throughout life.
Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification).
+
+
is hypertrophic pathological or normal? and can it be described using a pato term?
hypertrophic chondrocyte
@@ -20487,15 +20478,15 @@ radial glial cells acting as neural progenitors throughout life.
HC
doi:10.1038/s41598-020-66092-9
-
+
HCs
doi:10.1038/s41598-020-66092-9
+
-
@@ -20648,23 +20639,23 @@ radial glial cells acting as neural progenitors throughout life.
BC
doi:10.1038/s41598-020-66092-9
-
+
BCs
doi:10.1038/s41598-020-66092-9
+
-
BPs
GSE137537
+
-
@@ -21308,8 +21299,6 @@ radial glial cells acting as neural progenitors throughout life.
A cell of the monocyte, granulocyte, or mast cell lineage.
-
-
myeloid leukocyte
@@ -22136,13 +22125,11 @@ radial glial cells acting as neural progenitors throughout life.
A dendritic cell of the myeloid lineage.
-
interdigitating cell
veiled cell
BTO:0004721
CD11c+CD123- DC
mDC
-
These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
myeloid dendritic cell
@@ -23009,7 +22996,7 @@ radial glial cells acting as neural progenitors throughout life.
gd T cell
-
+
@@ -26154,10 +26141,12 @@ radial glial cells acting as neural progenitors throughout life.
A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
+
FMA:84642
FMA:84644
fixed macrophage
resting histiocyte
+
tissue-resident macrophage
@@ -29810,10 +29799,12 @@ radial glial cells acting as neural progenitors throughout life.
A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative.
+
lymphoid-primed multipotent progenitor
ELP
GMLP
LMPP
+
Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative.
early lymphoid progenitor
@@ -29838,20 +29829,20 @@ radial glial cells acting as neural progenitors throughout life.
ELP
-
+
GMLP
PMID:18371378
-
+
LMPP
-
+
@@ -35759,21 +35750,21 @@ radial glial cells acting as neural progenitors throughout life.
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -36197,13 +36188,13 @@ radial glial cells acting as neural progenitors throughout life.
BFU-E
-
+
CFU-E
-
+
@@ -40869,7 +40860,7 @@ radial glial cells acting as neural progenitors throughout life.
P cell
-
+
@@ -45038,7 +45029,7 @@ radial glial cells acting as neural progenitors throughout life.
HpSC
PMID:18442648
-
+
@@ -45241,11 +45232,9 @@ radial glial cells acting as neural progenitors throughout life.
An epithelial cell of the tracheobronchial tree.
-
2010-09-02T02:09:14Z
FMA:66816
-
epithelial cell of tracheobronchial tree
@@ -46378,13 +46367,11 @@ radial glial cells acting as neural progenitors throughout life.
A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.
-
2010-09-07T02:29:38Z
FMA:84467
pulmonary myofibroblast
pulmonary septal cell
-
pulmonary interstitial fibroblast
@@ -48454,7 +48441,6 @@ radial glial cells acting as neural progenitors throughout life.
An ecto-epithelial cell of the prostate gland that secretes hormones.
-
2010-09-14T03:01:58Z
CALOHA:TS-1280
@@ -48462,7 +48448,6 @@ radial glial cells acting as neural progenitors throughout life.
FMA:86774
glandular cell of prostate
neuro-epithelial cell of prostate gland
-
endocrine-paracrine cell of prostate gland
@@ -48644,13 +48629,11 @@ radial glial cells acting as neural progenitors throughout life.
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -48808,16 +48791,28 @@ radial glial cells acting as neural progenitors throughout life.
- The milk-producing cell of the alveolar unit that emerges during pregnancy.
+
+
+
+
+
+
+ A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland.
+
+
2010-09-20T01:30:57Z
+ mammary alveolar cell
FMA:74506
FMA:79866
epithelial cell of lactiferous gland
+ lactaction-associated mammary epithelial cell
+ lactation-derived mammary cell
luminal cell of alveolus of lactiferous gland
mammary alveolar epithelial cell
mammary gland alveolar epithelial cell
- mammary alveolar cell
+ LMC
+ lactocyte
@@ -48828,9 +48823,38 @@ radial glial cells acting as neural progenitors throughout life.
- The milk-producing cell of the alveolar unit that emerges during pregnancy.
+ A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland.
GOC:tfm
PMID:19022771
+ PMID:28717367
+ PMID:35091553
+ PMID:35377806
+ doi:10.1177/156482659601700404
+
+
+
+
+ mammary alveolar cell
+ PMID:19022771
+
+
+
+
+ lactaction-associated mammary epithelial cell
+ PMID:35091553
+
+
+
+
+ lactation-derived mammary cell
+ PMID:35091553
+
+
+
+
+ LMC
+ PMID:35091553
+
@@ -49316,10 +49340,12 @@ radial glial cells acting as neural progenitors throughout life.
A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy.
+
2010-09-20T04:00:02Z
dNK cell
decidual NK cell
+
decidual natural killer cell, human
@@ -50175,7 +50201,7 @@ radial glial cells acting as neural progenitors throughout life.
GCP
doi:10.3389/fncir.2020.611841
-
+
@@ -52664,7 +52690,7 @@ radial glial cells acting as neural progenitors throughout life.
T.4SP24-.Th
-
+
@@ -53260,14 +53286,14 @@ radial glial cells acting as neural progenitors throughout life.
O-2A/OPC
PMID:24133281
-
+
O2A/OPC
PMID:11756508
-
+
@@ -54215,7 +54241,7 @@ radial glial cells acting as neural progenitors throughout life.
MF.BM
-
+
@@ -56489,8 +56515,10 @@ radial glial cells acting as neural progenitors throughout life.
A mesenchymal stem cell of the chorionic membrane.
+
2011-02-28T03:04:35Z
+
chorionic membrane mesenchymal stem cell
@@ -56841,12 +56869,10 @@ radial glial cells acting as neural progenitors throughout life.
A fibroblast that is part of lung.
-
2011-02-28T05:11:03Z
BTO:0000764
CALOHA:TS-0575
-
fibroblast of lung
@@ -56985,8 +57011,10 @@ radial glial cells acting as neural progenitors throughout life.
A fibroblast of pulmonary artery.
+
2011-02-28T05:22:27Z
+
fibroblast of pulmonary artery
@@ -57015,8 +57043,10 @@ radial glial cells acting as neural progenitors throughout life.
A fibroblast that is part of villous mesenchyme.
+
2011-02-28T05:24:28Z
+
fibroblast of villous mesenchyme
@@ -58093,9 +58123,11 @@ radial glial cells acting as neural progenitors throughout life.
A smooth muscle of the pulmonary artery.
+
2011-03-06T05:01:28Z
BTO:0003336
+
smooth muscle cell of the pulmonary artery
@@ -60265,7 +60297,7 @@ radial glial cells acting as neural progenitors throughout life.
CPC
PMID:19745164
-
+
@@ -60753,17 +60785,11 @@ radial glial cells acting as neural progenitors throughout life.
-
+ A cell that is part of a cortex of kidney.
2011-10-25T03:49:41Z
kidney cortical cell
-
-
-
-
- true
-
@@ -62872,7 +62898,7 @@ radial glial cells acting as neural progenitors throughout life.
H1
doi:10.1038/s41598-020-66092-9
-
+
@@ -62907,7 +62933,7 @@ radial glial cells acting as neural progenitors throughout life.
H2
doi:10.1038/s41598-020-66092-9
-
+
@@ -64197,6 +64223,8 @@ radial glial cells acting as neural progenitors throughout life.
Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment.
+
+
ionocyte
@@ -64221,6 +64249,12 @@ radial glial cells acting as neural progenitors throughout life.
Kolmer-Agduhr cell
Kolmer-Agduhr neuron
+
+
+
+ Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons.
+ PMID:18680739
+
@@ -64233,12 +64267,6 @@ radial glial cells acting as neural progenitors throughout life.
KA neuron
PMID:9634146
-
-
-
- Kolmer-Agduhr neurons are ciliated GABAergic neurons that contact the central canal of the spinal cord and have ipsilateral ascending axons.
- PMID:18680739
-
@@ -64390,7 +64418,7 @@ radial glial cells acting as neural progenitors throughout life.
MCC
-
+
@@ -65385,8 +65413,6 @@ Covers cells actively being cultured or stored in a quiescent state for future u
Any muscle cell in which the fibers are not organised into sarcomeres.
-
-
non-striated muscle cell
@@ -65792,18 +65818,18 @@ Covers cells actively being cultured or stored in a quiescent state for future u
-
+
A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage.
activated skeletal muscle satellite cell
-
+
-
+
More accurately - transformation_of ?
@@ -65891,7 +65917,9 @@ Covers cells actively being cultured or stored in a quiescent state for future u
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -66513,7 +66541,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
2020-09-28T09:52:58Z
pyramidal cell of Betz
Betz cell
- https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg
+ https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg
@@ -69061,11 +69089,13 @@ Covers cells actively being cultured or stored in a quiescent state for future u
An epithelial cell that is part of an endometrial gland.
+
2021-11-30T16:13:30Z
EFO:0010710
endometrial glandular epithelial cell
+
epithelial cell of endometrial gland
@@ -69531,9 +69561,11 @@ Covers cells actively being cultured or stored in a quiescent state for future u
A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.
+
2022-03-17T12:00:44Z
portal fibroblast
+
hepatic portal fibroblast
@@ -69748,7 +69780,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u
MedRC
-
+
@@ -70004,7 +70036,9 @@ Covers cells actively being cultured or stored in a quiescent state for future u
An endothelial cell located in a lymph node lymphatic vessel.
+
+
lymph node lymphatic vessel endothelial cell
https://github.com/obophenotype/cell-ontology/issues/1472
@@ -71873,9 +71907,11 @@ plexiform layer using GABA.
A neuroendocrine cell that is part of the prostate epithelium.
+
neuroendocrine cell of prostate epithelium
neuroendocrine cell of the prostate
+
prostate neuroendocrine cell
@@ -72440,10 +72476,12 @@ plexiform layer using GABA.
Any goblet cell that is part of the tracheobronchial epithelium.
+
2020-05-07T18:14:52Z
goblet cell of tracheobronchial tree
+
tracheobronchial goblet cell
@@ -73111,8 +73149,6 @@ plexiform layer using GABA.
-
-
lung goblet cell
@@ -73319,7 +73355,7 @@ plexiform layer using GABA.
PNEC
PMID:33355253
-
+
@@ -79179,8 +79215,10 @@ plexiform layer using GABA.
A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role.
+
FMA:84150
urothelial basal cell
+
It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells.
basal cell of urothelium
@@ -79465,7 +79503,9 @@ plexiform layer using GABA.
A mesothelial cell that is part of the visceral pleura.
+
FMA:86739
+
mesothelial cell of visceral pleura
@@ -79563,6 +79603,7 @@ plexiform layer using GABA.
+ A cell that is part of a kidney.
KUPO:0001010
kidney cell
@@ -79583,22 +79624,10 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+ A cell that is part of kidney interstitium.
KUPO:0001013
kidney interstitial cell
-
-
-
-
- true
-
@@ -79616,22 +79645,10 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+ A cell that is part of a renal medulla.
KUPO:0001017
kidney medulla cell
-
-
-
-
- true
-
@@ -79649,22 +79666,10 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+ A cell that is part of a renal pelvis.
KUPO:0001018
kidney pelvis cell
-
-
-
-
- true
-
@@ -79682,22 +79687,10 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+ A cell that is part of a nephron tubule.
KUPO:0001020
kidney tubule cell
-
-
-
-
- true
-
@@ -79740,7 +79733,7 @@ plexiform layer using GABA.
-
+
@@ -79748,22 +79741,10 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+ An epithelial cell that is part of a renal medulla collecting duct.
KUPO:0001060
kidney medulla collecting duct epithelial cell
-
-
-
-
- true
-
@@ -79773,7 +79754,7 @@ plexiform layer using GABA.
-
+
@@ -79781,23 +79762,11 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+
An epithelial cell that is part of some inner medullary collecting duct.
KUPO:0001061
kidney inner medulla collecting duct epithelial cell
-
-
-
-
- true
-
@@ -79807,7 +79776,7 @@ plexiform layer using GABA.
-
+
@@ -79815,22 +79784,11 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+
+ An epithelial cell that is part of an outer medullary collecting duct.
KUPO:0001062
kidney outer medulla collecting duct epithelial cell
-
-
-
-
- true
-
@@ -79840,7 +79798,7 @@ plexiform layer using GABA.
-
+
@@ -79848,22 +79806,10 @@ plexiform layer using GABA.
-
-
-
-
-
-
-
+ An epithelial cell that is part of a cortical collecting duct.
KUPO:0001063
kidney cortex collecting duct epithelial cell
-
-
-
-
- true
-
@@ -81476,7 +81422,9 @@ plexiform layer using GABA.
+
KUPO:0001118
+
ureter smooth muscle cell
@@ -82866,17 +82814,11 @@ plexiform layer using GABA.
-
+ A cell that is part of a collecting duct of renal tubule.
KUPO:0001012
Wikipedia:Kidney_collecting_duct_cell
kidney collecting duct cell
-
-
-
-
- true
-
@@ -83705,10 +83647,8 @@ plexiform layer using GABA.
-
endothelial cell of lung
pulmonary vessel endothelial cell
-
lung endothelial cell
@@ -83734,8 +83674,10 @@ plexiform layer using GABA.
+
BTO:0001141
PAEC cell
+
pulmonary artery endothelial cell
@@ -85216,7 +85158,9 @@ plexiform layer using GABA.
Chondrocyte forming the hyaline cartilage found in joints.
+
CALOHA:TS-0056
+
articular chondrocyte
@@ -87072,11 +87016,9 @@ plexiform layer using GABA.
Any microvascular endothelial cell that is part of a prostate gland.
-
2014-10-07T17:46:27Z
CL:2000059
-
http://www.sciencellonline.com/site/productInformation.php?keyword=4400
prostate gland microvascular endothelial cell
@@ -87145,9 +87087,11 @@ plexiform layer using GABA.
Any mesenchymal stem cell that is part of a placenta.
+
2014-10-07T17:51:11Z
CL:2000061
+
http://www.sciencellonline.com/site/productInformation.php?keyword=7140
placental amniotic mesenchymal stromal cell
@@ -87175,11 +87119,9 @@ plexiform layer using GABA.
Any capillary endothelial cell that is part of a placenta.
-
2014-10-07T17:55:56Z
CL:2000062
-
http://www.ncbi.nlm.nih.gov/books/NBK53245/
placental villus capillary endothelial cell
@@ -88274,21 +88216,43 @@ plexiform layer using GABA.
-
- Oval eosinophilic histiocytes with granules and vacuoles found in placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy.
-
+
+
+
+
+
+
+
+ A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin and is present throughout pregnancy.
+
2019-02-18T19:41:20Z
+ HBC
CL:3000001
-
+ Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve.
Hofbauer cell
- Oval eosinophilic histiocytes with granules and vacuoles found in placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy.
+ A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin and is present throughout pregnancy.
GOC:CellBLAST
PMID:30429548
+ PMID:30498493
+ PMID:34745147
+ PMID:35438172
+
+
+
+
+ HBC
+
+
+
+
+
+ Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve.
+ PMID:30498493
@@ -88847,9 +88811,11 @@ plexiform layer using GABA.
CT glut
A glutamatergic neuron located in the cerebral cortex that projects to the thalamus.
+
CT projecting neuron
+
corticothalamic-projecting glutamatergic cortical neuron
@@ -89352,14 +89318,14 @@ plexiform layer using GABA.
D1-MSN
PMID:34727523
-
+
dSPN
PMID:30096299
-
+
@@ -89501,7 +89467,7 @@ plexiform layer using GABA.
D2-MSN
PMID:34727523
-
+
@@ -89514,7 +89480,7 @@ plexiform layer using GABA.
iSPN
PMID:30096299
-
+
@@ -89893,7 +89859,7 @@ plexiform layer using GABA.
L5b neuron
DOI:10.1016/j.neuron.2011.07.029
-
+
@@ -90074,15 +90040,11 @@ plexiform layer using GABA.
-
+
-
-
-
-
@@ -90109,15 +90071,11 @@ plexiform layer using GABA.
-
+
-
-
-
-
@@ -90145,15 +90103,11 @@ plexiform layer using GABA.
-
+
-
-
-
-
@@ -90181,15 +90135,11 @@ plexiform layer using GABA.
-
+
-
-
-
-
@@ -90371,43 +90321,43 @@ plexiform layer using GABA.
-
-
-
+
+
+
A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain.
VLMC (Mus musculus)
vascular leptomeningeal cell (Mmus)
-
+
-
+
-
+
-
+
PMID:30096314
-
+
PMID:30096314
-
+
PMID:30096314
@@ -90498,7 +90448,7 @@ plexiform layer using GABA.
COP
-
+
@@ -90903,9 +90853,7 @@ plexiform layer using GABA.
OBSOLETE. A cell that is part of the choroid plexus.
-
-
https://github.com/obophenotype/cell-ontology/issues/2043
obsolete choroid plexus cell
true
@@ -91175,7 +91123,7 @@ plexiform layer using GABA.
-
+
@@ -91183,20 +91131,28 @@ plexiform layer using GABA.
- An interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling a chandelier. Chandelier cells can be multipolar or bitufted.
+ A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted.
+ axo-axonic cell
ILX:0777213
- ChC
+ ChC
chandelier cell
- An interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling a chandelier. Chandelier cells can be multipolar or bitufted.
+ A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted.
PMID:15378039
PMID:27199673
+
+
+
+ axo-axonic cell
+ PMID:27199673
+ PMID:33862423
+
@@ -91205,9 +91161,10 @@ plexiform layer using GABA.
-
+
ChC
PMID:15378039
+
@@ -91525,14 +91482,14 @@ plexiform layer using GABA.
AB cell
PMID:23298861
-
+
ABC
PMID:30096314
-
+
@@ -92244,7 +92201,7 @@ plexiform layer using GABA.
OxtrINs
PMID:25303526
-
+
@@ -92696,7 +92653,7 @@ plexiform layer using GABA.
A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive.
- SBC
+ SBC
spherical bushy cell
@@ -92708,10 +92665,10 @@ plexiform layer using GABA.
-
+
SBC
PMID:31881018
-
+
@@ -92737,7 +92694,7 @@ plexiform layer using GABA.
GBC
PMID:31881018
-
+
@@ -93048,14 +93005,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
CAP1
-
+
gCAP
PMID:33057196
-
+
@@ -93103,7 +93060,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
aCAP
-
+
@@ -93152,7 +93109,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
AF1
-
+
@@ -93196,13 +93153,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
AF2
-
+
MANC
-
+
@@ -93493,10 +93450,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An epithelial cell that is part of the fallopian tube epithelium that secretes mucous fluid and oviduct-specific products through the stimulation of estrogen and luteinizing hormone. The fallopian tube secretory cell has approximately the same height as the ciliated cell and is usually a more narrow columnar cell. The nucleus is ovoid and perpendicular to the long axis of the cell. The chromatin is more dense and the nucleolus smaller than that seen in the ciliated cell.
+
2022-03-03T10:39:31Z
oviduct secretory epithelial cell
uterine tube secretory epithelial cell
+
The other cell types of the fallopian tube epithelium include the ciliated cell and the intercalary cell, or peg cell. The fallopian tube secretory epithelial cell type has been implicated as a source of high-grade serous ovarian carcinoma.
fallopian tube secretory epithelial cell
@@ -93536,10 +93495,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An epithelial ciliated cell that is part of the fallopian tube. This cell type is found mainly on the apex of the mucosal folds and contributes, together with peristaltic contractions, to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube. A fallopian tube ciliated cell has a columnar shape and contains an oval or round nucleus, often located perpendicular or parallel to the long axis of the cell.
+
2022-03-08T12:40:19Z
oviduct ciliated cell
uterine tube ciliated epithelial cell
+
fallopian tube ciliated cell
@@ -93878,6 +93839,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
A renal principal cell located in the connecting tubule.
@@ -94348,11 +94310,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.
+
2022-12-06T14:18:45Z
VIC
cardiac valve interstitial cell
valvular interstitial cell
+
Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis).
valve interstitial cell
@@ -94373,7 +94337,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
VIC
PMID:25311230
PMID:30796046
-
+
@@ -94424,7 +94388,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
VEC
PMID:25311230
PMID:30796046
-
+
@@ -94507,7 +94471,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DPSC
-
+
@@ -94689,7 +94653,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
VEN
PMID:32127543
-
+
@@ -94825,21 +94789,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D1-matrix
doi:10.1016/j.cub.2021.10.015
-
+
D1M
doi:10.1016/j.cub.2021.10.015
-
+
matrix D1-MSN
doi:10.1016/j.cub.2021.10.015
-
+
@@ -94889,21 +94853,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D2-matrix
doi:10.1016/j.cub.2021.10.015
-
+
D2M
doi:10.1016/j.cub.2021.10.015
-
+
matrix D2-MSN
doi:10.1016/j.cub.2021.10.015
-
+
@@ -94960,21 +94924,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D1-striosome
DOI:10.1016/j.cub.2021.10.015
-
+
D1S
doi:10.1016/j.cub.2021.10.015
-
+
striosome D1-MSN
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95031,21 +94995,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D2-striosome
doi:10.1016/j.cub.2021.10.015
-
+
D2S
doi:10.1016/j.cub.2021.10.015
-
+
striosome D2-MSN
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95098,28 +95062,28 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D1/2
doi:10.1016/j.cub.2021.10.015
-
+
D1/D2 hybrid
doi:10.1016/j.cub.2021.10.015
-
+
D1/D2-hybrid MSN
doi:10.1016/j.cub.2021.10.015
-
+
hybrid D1/2 cell type
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95171,14 +95135,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D1Sh
doi:10.1016/j.cub.2021.10.015
-
+
NAc shell and OT D1-MSN
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95231,21 +95195,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D2Sh
doi:10.1016/j.cub.2021.10.015
-
+
NAc shell and OT D2-MSN
doi:10.1016/j.cub.2021.10.015
-
+
nucleus accumbens shell and olfactory tubercle D2-MSN
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95299,7 +95263,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D1-ICj
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95356,7 +95320,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
D1-NUDAP
doi:10.1016/j.cub.2021.10.015
-
+
@@ -95372,10 +95336,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes.
+
https://orcid.org/0000-0003-3065-9183
2023-06-16T07:53:43Z
FMA:84155
urothelial intermediate cell
+
It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells.
intermediate cell of urothelium
@@ -95405,11 +95371,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled.
+
https://orcid.org/0000-0003-3065-9183
2023-06-16T07:59:43Z
FMA:84149
facet cell of urothelium
superficial cell of urothelium
+
Umbrella cells are attached to sub-superficial cell layers via desmosomes, while tight junctions localized between superficial cells aid in forming a high-resistance barrier function. Another distinguishing feature of an umbrella cell type is the presence of subapical discoidal/fusiform-shaped vesicles contributing to the plasticity in urothelial cell surface area through a regulated process of endocytosis/exocytosis. It has been noted in at least some mammalian species that the urothelial umbrella cell type expresses UPK1A, UPK1B, UPK2 and UPK3A. Unlike intermediate and basal cells of the urothelium, CK17 is reported to be completely absent and p63 not expressed in umbrella cells.
umbrella cell of urothelium
@@ -95471,21 +95439,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
eSPN
doi:10.1016/j.cell.2018.07.028
-
+
eccentric MSN
doi:10.1101/2022.10.12.511898
-
+
eccentric SPN
doi:10.1016/j.cell.2018.07.028
-
+
@@ -95497,6 +95465,361 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ A macrophage that expresses the T cell receptor complex at the cell surface.
+
+ 2023-09-26T12:27:14Z
+ T cell receptor positive macrophage
+ TCR+ macrophage
+ TCR.macs
+ TCR-positive macrophage
+
+
+
+
+ A macrophage that expresses the T cell receptor complex at the cell surface.
+
+ PMID:26074923
+
+
+
+
+ T cell receptor positive macrophage
+ PMID:26074923
+
+
+
+
+ TCR+ macrophage
+ PMID:26074923
+
+
+
+
+ TCR.macs
+
+ PMID:37500727
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3.
+
+ 2023-10-10T14:10:21Z
+ L2/3 IT
+ L2/3 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3.
+ PMID:34004146
+ PMID:37292694
+
+
+
+
+ L2/3 IT
+ PMID:34004146
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2.
+
+ 2023-10-10T14:10:36Z
+ L2 IT
+ L2 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2.
+ PMID:34004146
+
+
+
+
+ L2 IT
+ PMID:34004146
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3.
+
+ 2023-10-10T14:10:47Z
+ L3 IT
+ L3 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3.
+ PMID:34004146
+
+
+
+
+ L3 IT
+ PMID:34004146
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5.
+
+ 2023-10-10T14:11:04Z
+ L4/5 IT
+ L4/5 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5.
+ PMID:34004146
+
+
+
+
+ L4/5 IT
+ PMID:34004146
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 4.
+
+ 2023-10-10T14:11:25Z
+ L4 IT
+ L4 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 4.
+ PMID:37292694
+
+
+
+
+ L4 IT
+ PMID:37292694
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5.
+
+ 2023-10-10T14:11:59Z
+ L5 IT
+ L5 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5.
+ PMID:37292694
+ PMID:37609206
+
+
+
+
+ L5 IT
+
+ PMID:37292694
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 6.
+
+ 2023-10-10T14:12:23Z
+ L6 IT
+ L6 intratelencephalic projecting glutamatergic neuron
+
+
+
+
+ An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 6.
+ PMID:37292694
+ PMID:37609206
+
+
+
+
+ L6 IT
+ PMID:37292694
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion.
+ https://orcid.org/0000-0002-1425-877X
+ 2023-10-13T11:22:42Z
+ UB cell
+ ureteric bud cell
+
+
+
+
+
+
+
+
+
+ PMID:9374839
+
+
+
+
+ An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion.
+ PMID:17133361
+ PMID:24183650
+ PMID:9374839
+
+
+
+
+ UB cell
+ PMID:24183650
+
+
+
+
+
@@ -95744,7 +96067,9 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A(n) serous secreting cell that is part of a(n) bronchus submucosal gland.
+
+
serous secreting cell of bronchus submucosal gland
@@ -95996,12 +96321,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6.
+
2023-02-02T15:07:12Z
FTE stem-like cell
FTESC
fallopian tube epithelial stem-like cell
intercalary cell
+
In vitro evidence supports a stem-cell/regenerative function for these cells
peg cell
@@ -96024,7 +96351,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
FTESC
PMID:22911892
-
+
@@ -96139,15 +96466,15 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
SCMF
PMID:33624948
-
+
SCMFs
PMID:25448080
+
-
@@ -96246,15 +96573,15 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
MKL
PMID:36524131
-
+
lung MKs
PMID:33351116
+
-
@@ -96283,7 +96610,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
BB cell
PMID:32032773
-
+
@@ -96504,10 +96831,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A perichondrial fibroblast that is part of the lung.
+
2023-03-16T16:15:39Z
PC-fibro
+
lung perichondrial fibroblast
@@ -96521,7 +96850,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
PC-fibro
PMID:36543915
-
+
@@ -96559,21 +96888,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DB1 bipolar
PMID:22006647
-
+
DB1 bipolar cell
PMID:22006647
-
+
DB1 cell
PMID:32032773
-
+
@@ -96611,7 +96940,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DB2 cell
PMID:32032773
-
+
@@ -96649,14 +96978,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DB3 cell
DOI:10.3389/fnana.2015.00122
-
+
DB3a cell
PMID:32032773
-
+
@@ -96693,7 +97022,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DB3b cell
PMID:32032773
-
+
@@ -96731,7 +97060,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DB4 cell
PMID:32032773
-
+
@@ -96760,7 +97089,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
DB6 cell
PMID:32032773
-
+
@@ -96789,7 +97118,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
FMB cell
PMID:32032773
-
+
@@ -96818,7 +97147,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
IMB cell
PMID:32032773
-
+
@@ -96846,7 +97175,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
GB cell
PMID:32032773
-
+
@@ -96928,11 +97257,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An alpha-beta CD4 T cell that resides in the lung.
+
2023-04-27T10:15:45Z
lung resident memory CD4 T cell
lung CD4-positive TRM
+
lung resident memory CD4-positive, alpha-beta T cell
@@ -96953,7 +97284,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
lung CD4-positive TRM
PMID:31265968
-
+
@@ -96969,10 +97300,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An alpha-beta CD8 T cell that resides in the lung.
+
2023-04-27T10:16:07Z
lung CD8-positive TRM
+
In the lung, CXCR6 regulates the localization of lung resident memory CD8-positive, alpha-beta T cells.
lung resident memory CD8-positive, alpha-beta T cell
@@ -96988,7 +97321,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
lung CD8-positive TRM
PMID:31265968
-
+
@@ -97060,10 +97393,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An alveolar macrophage that expresses CCL3.
+
2023-06-15T12:53:08Z
alveolar macrophage CCL3-positive
+
CCL3-positive alveolar macrophage
@@ -97086,11 +97421,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An alveolar macrophage that expresses metallothionein.
+
2023-06-15T12:55:34Z
alveolar macrophage MT-positive
alveolar macrophage metallothionein-positive
+
metallothionein-positive alveolar macrophage
@@ -97125,10 +97462,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation.
+
2023-06-15T12:58:11Z
lung IM
+
lung interstitial macrophage
@@ -97144,7 +97483,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
lung IM
PMID:36211428
-
+
@@ -97160,9 +97499,11 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis.
+
2023-06-20T10:27:17Z
+
In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification.
deuterosomal cell
@@ -97191,11 +97532,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells.
+
2023-06-21T10:04:46Z
lung mDC
lung mDCs
+
lung migratory dendritic cell
@@ -97209,15 +97552,15 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
lung mDC
PMID:34516781
-
+
lung mDCs
PMID:34516781
+
-
@@ -97332,11 +97675,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A respiratory epithelial cell with topographic nuclear position in between the basal and luminal cell of the airway epithelium. This non-basal, intermediate cell has limited proliferative capacity, ultrastructural features of basal cells and no defined features of the typically differentiated cellular phenotypes.
+
2023-06-20T10:44:30Z
respiratory parabasal cell
respiratory suprabasal progenitor cell
+
In humans, respiratory suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3.
respiratory suprabasal cell
@@ -97586,14 +97931,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
SBS ganglion cell
PMID:32032773
-
+
sbRGC
PMID:34093409
-
+
@@ -97646,9 +97991,11 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A ciliated cell that is part of a ciliated duct of an airway submucosal gland.
+
2023-09-08T10:32:27Z
+
airway submucosal gland duct ciliated cell
@@ -97661,6 +98008,333 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
+
+
+
+
+ A differentiated flat keratinocyte that is part of a nail plate. An onychocyte is firmly adherent and does not desquamate.
+
+ 2023-10-03T12:49:46Z
+ onychocyte
+
+
+
+
+ A differentiated flat keratinocyte that is part of a nail plate. An onychocyte is firmly adherent and does not desquamate.
+ PMID:24079581
+
+
+
+
+
+
+
+
+
+ A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8.
+
+
+ 2023-10-13T13:02:55Z
+ alveolar cell
+ alveolar progenitor
+ luminal progenitor
+ luminal progenitor cell
+ luminal secretory cell
+ ER-negative luminal alveolar progenitor
+ AP
+ AV
+ LASP
+ LP
+ LumSec
+ luminal adaptive secretory precursor cell of mammary gland
+
+
+
+
+ A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8.
+ PMID:19648928
+ PMID:35617956
+ https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
+ https://orcid.org/0000-0001-6677-8489
+
+
+
+
+ alveolar cell
+ PMID:35617956
+
+
+
+
+ alveolar progenitor
+ PMID:26390871
+
+
+
+
+ luminal progenitor
+ doi:10.1101/2023.04.21.537845
+
+
+
+
+ luminal progenitor cell
+ PMID:20346151
+
+
+
+
+ luminal secretory cell
+ PMID:37380767
+
+
+
+
+ ER-negative luminal alveolar progenitor
+ https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
+
+
+
+
+ AP
+ https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
+
+
+
+
+
+ AV
+ PMID:35617956
+
+
+
+
+
+ LASP
+ https://orcid.org/0000-0001-6677-8489
+
+
+
+
+
+ LP
+ doi:10.1101/2023.04.21.537845
+
+
+
+
+
+ LumSec
+ PMID:37380767
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+ A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a).
+
+
+ 2023-10-16T08:30:25Z
+ hormone sensing cell
+ hormone-sensing mammary epithelial cell
+ luminal hormone-responsive cell
+ luminal mature cell
+ ER-positive luminal hormone-sensor cell
+ HS
+ HS-MEC
+ LHS
+ LumHR
+ Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad.
+ luminal hormone-sensing cell of mammary gland
+
+
+
+
+ A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a).
+ PMID:19648928
+ PMID:26390871
+ PMID:34156490
+ https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
+ https://orcid.org/0000-0001-6677-8489
+
+
+
+
+ hormone sensing cell
+ doi:10.1101/2023.04.21.537845
+
+
+
+
+ hormone-sensing mammary epithelial cell
+ PMID:26390871
+
+
+
+
+ luminal hormone-responsive cell
+ PMID:37380767
+
+
+
+
+ luminal mature cell
+ PMID:20346151
+
+
+
+
+ ER-positive luminal hormone-sensor cell
+ https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328
+
+
+
+
+ HS
+ doi:10.1101/2023.04.21.537845
+
+
+
+
+
+ HS-MEC
+ PMID:26390871
+
+
+
+
+
+ LHS
+ https://orcid.org/0000-0001-6677-8489
+
+
+
+
+
+ LumHR
+ PMID:37380767
+
+
+
+
+
+ Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad.
+ PMID:26390871
+ PMID:34156490
+ https://orcid.org/0000-0003-4969-670X
+
+
+
+
+
+
+
+
+ A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2.
+
+
+ 2023-10-16T13:15:36Z
+ luminal cluster 1 cell
+ LC1
+ LMC major luminal cluster 1
+ progenitor MEC
+ lactocyte type 1
+
+
+
+
+ A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2.
+ PMID:35091553
+ PMID:35377806
+
+
+
+
+ luminal cluster 1 cell
+ PMID:34097179
+
+
+
+
+ LC1
+ PMID:35091553
+
+
+
+
+
+ LMC major luminal cluster 1
+ PMID:35091553
+
+
+
+
+ progenitor MEC
+ PMID:35091553
+
+
+
+
+
+
+
+
+
+ A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis.
+
+
+ 2023-10-16T13:15:55Z
+ luminal cluster 2 cell
+ LC2
+ LMC major luminal cluster 2
+ lactocyte type 2
+
+
+
+
+ A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis.
+ PMID:35091553
+ PMID:35377806
+
+
+
+
+ luminal cluster 2 cell
+ PMID:35377806
+
+
+
+
+ LC2
+ PMID:35091553
+
+
+
+
+
+ LMC major luminal cluster 2
+ PMID:35091553
+
+
+
+
@@ -97697,7 +98371,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
GRP cell
PMID:11756508
-
+
@@ -99685,6 +100359,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -101137,6 +101817,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -101737,6 +102423,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -101857,6 +102549,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -104743,6 +105441,18 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
+
+
+
+
+
+
@@ -104989,6 +105699,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -105787,14 +106503,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
-
+
-
+
-
+
@@ -105802,5 +106518,5 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
-
+
diff --git a/cl.obo b/cl.obo
index ab1b56667..343fc916d 100644
--- a/cl.obo
+++ b/cl.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: releases/2023-09-21
+data-version: releases/2023-10-19
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,7 +82,6 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
@@ -110,7 +101,7 @@ property_value: dc-description "An ontology of cell types." xsd:string
property_value: dc-title "Cell Ontology" xsd:string
property_value: dcterms-license http://creativecommons.org/licenses/by/4.0/
property_value: has_ontology_root_term CL:0000000
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -180,8 +171,7 @@ relationship: part_of BFO:0000020 {all_only="true"} ! specifically dependent con
id: BFO:0000023
name: role
def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." []
-is_a: CHEBI:50906
-equivalent_to: CHEBI:50906
+is_a: BFO:0000017 ! realizable entity
[Term]
id: BFO:0000031
@@ -208,394 +198,15 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-disjoint_from: CARO:0000004 ! organism substance
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000004
-name: organism substance
-def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body and that does not have inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note - CARO explicitly declares organisms substances to be part of (some) organism.
-synonym: "portion of organism substance" EXACT []
-is_a: CARO:0001008 ! gross anatomical part
-property_value: IAO:0000112 "Examples include feces, urine, blood, blood plasma, lymph, hemolymph, cerbro-spinal fluid. This class does not encompass anatomical entities with inherent 3D structure such as dentine and arthropod cuticle." xsd:string
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-disjoint_from: CARO:0000007 ! immaterial anatomical entity
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000007
-name: immaterial anatomical entity
-def: "Anatomical entity that has no mass." []
-subset: core
-is_a: BFO:0000141 ! immaterial entity
-is_a: CARO:0000000 ! anatomical entity
-
-[Term]
-id: CARO:0000010
-name: anatomical boundary
-def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." []
-comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms.
-is_a: BFO:0000009
-is_a: CARO:0000007 ! immaterial anatomical entity
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0000013
-name: cell
-def: "An anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." []
-comment: deprecate and replace with CL or GO term?
-xref: CL:0000000
-xref: GO:0005623
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0020003 ! cellular anatomical structure
-disjoint_from: CARO:0000014 ! cell part
-disjoint_from: CARO:0000040 ! acellular anatomical structure
-disjoint_from: CARO:0000042 ! extraembryonic structure
-disjoint_from: CARO:0001000 ! multi-cell-part structure
-disjoint_from: CARO:0010000 ! multicellular anatomical structure
-
-[Term]
-id: CARO:0000014
-name: cell part
-def: "Anatomical structure that is part of a cell and that has a granularity level equal to that of a protein complex or higher." []
-comment: This is declared equivalent with GO:0044464. The definition should be co-ordinated with GO. We could obsolete the CARO class and just use the GO class.
-is_a: CARO:0000003 ! connected anatomical structure
-disjoint_from: CARO:0000040 ! acellular anatomical structure
-disjoint_from: CARO:0000042 ! extraembryonic structure
-disjoint_from: CARO:0001000 ! multi-cell-part structure
-disjoint_from: CARO:0010000 ! multicellular anatomical structure
-relationship: part_of CARO:0000013 ! cell
-property_value: IAO:0000118 "cell component" xsd:string
-
-[Term]
-id: CARO:0000032
-name: organism subdivision
-def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." []
-subset: core
-is_a: CARO:0010000 ! multicellular anatomical structure
-property_value: editor_note "Old definition: Anatomical structure which is a primary subdivision of whole organism. The mereological sum of these is the whole organism." xsd:string
-
-[Term]
-id: CARO:0000040
-name: acellular anatomical structure
-def: "An anatomical structure that has no cells or cell parts as a part." []
-comment: Example. Insect cuticle, eggshell, hair.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 ! connected anatomical structure
-intersection_of: has_component CARO:0000013 {cardinality="0"} ! cell
-intersection_of: has_component CARO:0000014 {cardinality="0"} ! cell part
-disjoint_from: CARO:0000042 ! extraembryonic structure
-disjoint_from: CARO:0001000 ! multi-cell-part structure
-disjoint_from: CARO:0010000 ! multicellular anatomical structure
-
-[Term]
-id: CARO:0000042
-name: extraembryonic structure
-def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." []
-comment: MH: define as not part of embryo, or will not develop into embryo? MH: changed def to exclude cells so this class could be included in gross anatomical part. DOS: Changed to something that I think works for both vertebrates and invertebrates and that keeps the restriction to multicellular structures. Old def: "Anatomical structure that is contiguous with the embryo and is comprised of portions of tissue that will not contribute to the embryo.". One remaining question - perhaps zygote is too restrictive given that some organisms have parthenogenesis e.g. aphids?\n
-subset: plus
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-disjoint_from: CARO:0001000 ! multi-cell-part structure
-disjoint_from: CARO:0010000 ! multicellular anatomical structure
-
-[Term]
-id: CARO:0001000
-name: multi-cell-part structure
-def: "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." []
-comment: Examples: a bundle of neuron projections in the brain; a region neuropil in an arthropod central nervous system; a region of cortex (preikaryal rind) in an arthropod brain.
-subset: core
-is_a: CARO:0001008 ! gross anatomical part
-disjoint_from: CARO:0010000 ! multicellular anatomical structure
-property_value: IAO:0000118 "multi-cell-component structure" xsd:string
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-union_of: CARO:0000004 ! organism substance
-union_of: CARO:0000032 ! organism subdivision
-union_of: CARO:0000040 ! acellular anatomical structure
-union_of: CARO:0000042 ! extraembryonic structure
-union_of: CARO:0001000 ! multi-cell-part structure
-union_of: CARO:0010000 ! multicellular anatomical structure
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0020000
-name: disconnected anatomical group
-def: "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." []
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0010001 ! disconnected
-intersection_of: has_component CARO:0000003 {minCardinality="2"} ! connected anatomical structure
-relationship: bearer_of PATO:0010001 ! disconnected
-relationship: has_component CARO:0000003 ! connected anatomical structure
-
-[Term]
-id: CARO:0020003
-name: cellular anatomical structure
-def: "An anatomical structure consisting of one or more cells." []
-is_a: CARO:0000006 ! material anatomical entity
-created_by: https://orcid.org/0000-0002-7073-9172
-creation_date: 2018-09-28T14:20:19Z
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:15355
-namespace: chebi_ontology
-def: "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter." [ANON:ANON]
-synonym: "2-acetyloxy-N,N,N-trimethylethanaminium" EXACT IUPAC_NAME [IUPAC:]
-synonym: "ACETYLCHOLINE" EXACT [PDBeChem:]
-synonym: "Acetylcholine" EXACT [KEGG COMPOUND:]
-synonym: "ACh" RELATED [ChemIDplus:]
-synonym: "Azetylcholin" RELATED [ChEBI:]
-synonym: "C7H16NO2" RELATED FORMULA [KEGG COMPOUND:]
-synonym: "CC(=O)OCC[N+](C)(C)C" RELATED SMILES [ChEBI:]
-synonym: "choline acetate" RELATED [ChemIDplus:]
-synonym: "InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1" RELATED InChI [ChEBI:]
-synonym: "InChIKey=OIPILFWXSMYKGL-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:]
-synonym: "O-Acetylcholine" RELATED [KEGG COMPOUND:]
-
-[Term]
-id: CHEBI:16670
-namespace: chebi_ontology
-def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid." [ANON:ANON]
-synonym: "C2H4NO2R(C2H2NOR)n" RELATED FORMULA [KEGG COMPOUND:]
-synonym: "Peptid" RELATED [ChEBI:]
-synonym: "Peptide" EXACT [KEGG COMPOUND:]
-synonym: "peptides" EXACT IUPAC_NAME [IUPAC:]
-synonym: "peptido" RELATED [ChEBI:]
-synonym: "peptidos" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:18059
-namespace: chebi_ontology
-def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." [ANON:ANON]
-synonym: "Lipid" EXACT [KEGG COMPOUND:]
-synonym: "lipid" EXACT [UniProt:]
-synonym: "lipids" EXACT IUPAC_NAME [IUPAC:]
-
[Term]
id: CHEBI:24431
-namespace: chebi_ontology
-def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [ANON:ANON]
is_a: BFO:0000040 ! material entity
-[Term]
-id: CHEBI:24780
-namespace: chebi_ontology
-def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [ANON:ANON]
-
-[Term]
-id: CHEBI:24828
-namespace: chebi_ontology
-def: "Any compound containing an indole skeleton." [ANON:ANON]
-
-[Term]
-id: CHEBI:25806
-namespace: chebi_ontology
-synonym: "oxygen molecular entities" RELATED [ChEBI:]
-synonym: "oxygen molecular entity" EXACT [ChEBI:]
-
-[Term]
-id: CHEBI:32952
-namespace: chebi_ontology
-def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [ANON:ANON]
-synonym: "Amin" RELATED [ChEBI:]
-synonym: "Amine" EXACT [KEGG COMPOUND:]
-synonym: "amines" EXACT IUPAC_NAME [IUPAC:]
-synonym: "an amine" RELATED [UniProt:]
-
-[Term]
-id: CHEBI:32988
-namespace: chebi_ontology
-def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ANON:ANON]
-synonym: "Amide" EXACT [KEGG COMPOUND:]
-synonym: "amides" EXACT IUPAC_NAME [IUPAC:]
-
-[Term]
-id: CHEBI:33566
-namespace: chebi_ontology
-
-[Term]
-id: CHEBI:33567
-namespace: chebi_ontology
-def: "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [ANON:ANON]
-synonym: "C8H9NO2R2" RELATED FORMULA [KEGG COMPOUND:]
-synonym: "Catecholamine" EXACT [KEGG COMPOUND:]
-synonym: "catecholamines" EXACT IUPAC_NAME [IUPAC:]
-synonym: "catecholamines" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:33655
-namespace: chebi_ontology
-def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." [ANON:ANON]
-synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC:]
-synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC:]
-synonym: "aromatics" RELATED [ChEBI:]
-synonym: "aromatische Verbindungen" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:33709
-namespace: chebi_ontology
-def: "A carboxylic acid containing one or more amino groups." [ANON:ANON]
-synonym: "amino acids" RELATED [ChEBI:]
-synonym: "Aminocarbonsaeure" RELATED [ChEBI:]
-synonym: "Aminokarbonsaeure" RELATED [ChEBI:]
-synonym: "Aminosaeure" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:33822
-namespace: chebi_ontology
-def: "An organic compound having at least one hydroxy group attached to a carbon atom." [ANON:ANON]
-synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC:]
-synonym: "organic hydroxy compounds" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:33832
-namespace: chebi_ontology
-synonym: "organic cyclic compounds" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:33853
-namespace: chebi_ontology
-def: "Compounds having one or more hydroxy groups attached to a benzene or other arene ring." [ANON:ANON]
-synonym: "arenols" RELATED [IUPAC:]
-synonym: "Aryl alcohol" RELATED [KEGG COMPOUND:]
-synonym: "aryl alcohol" RELATED [UniProt:]
-synonym: "phenols" EXACT IUPAC_NAME [IUPAC:]
-
-[Term]
-id: CHEBI:35352
-namespace: chebi_ontology
-def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." [ANON:ANON]
-synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC:]
-synonym: "organonitrogens" RELATED [ChEBI:]
-
[Term]
id: CHEBI:36080
is_a: PR:000000001 ! protein
equivalent_to: PR:000000001 ! protein
-[Term]
-id: CHEBI:50047
-namespace: chebi_ontology
-def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." [ANON:ANON]
-synonym: "organic amino compounds" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:50906
-is_a: BFO:0000023 ! role
-
-[Term]
-id: CHEBI:50994
-namespace: chebi_ontology
-def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." [ANON:ANON]
-synonym: "primary amino compounds" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:51143
-namespace: chebi_ontology
-synonym: "nitrogen compounds" RELATED [ChEBI:]
-synonym: "nitrogen molecular entities" RELATED [ChEBI:]
-synonym: "Nitrogenous compounds" RELATED [KEGG COMPOUND:]
-
-[Term]
-id: CHEBI:5686
-namespace: chebi_ontology
-def: "A cyclic compound having as ring members atoms of at least two different elements." [ANON:ANON]
-synonym: "compuesto heterociclico" RELATED [IUPAC:]
-synonym: "compuestos heterociclicos" RELATED [IUPAC:]
-synonym: "heterocycle" RELATED [ChEBI:]
-synonym: "Heterocyclic compound" EXACT [KEGG COMPOUND:]
-synonym: "heterocyclic compounds" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -900,7 +511,7 @@ xref: MESH:D010063
is_a: CL:0000675 {is_inferred="true"} ! female gamete
relationship: develops_from CL:0000023 ! oocyte
relationship: participates_in GO:0007143 ! female meiotic nuclear division
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Egg_cell.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Egg_cell.svg" xsd:anyURI
[Term]
id: CL:0000026
@@ -1020,7 +631,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -1066,10 +677,10 @@ id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
-synonym: "BFU-E" RELATED abbreviation []
+synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
-synonym: "CFU-E" RELATED abbreviation []
+synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
@@ -1092,7 +703,7 @@ id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
-synonym: "CFU-M" RELATED abbreviation []
+synonym: "CFU-M" RELATED OMO:0003000 []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
@@ -1231,9 +842,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -1278,13 +889,13 @@ alt_id: CL:0000044
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: human_reference_atlas
-synonym: "CLP" RELATED abbreviation []
+synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
-synonym: "ELP" RELATED abbreviation []
+synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
@@ -1474,7 +1085,7 @@ is_a: CL:0000000 ! cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000067
@@ -1599,14 +1210,12 @@ relationship: capable_of GO:0008015 ! blood circulation
id: CL:0000082
name: epithelial cell of lung
def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432]
-subset: human_reference_atlas
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000115 ! lung epithelium
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000083
@@ -2031,11 +1640,13 @@ is_a: CL:0000540 ! neuron
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149]
+subset: human_reference_atlas
xref: BTO:0001433
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: bearer_of PATO:0001407 ! mononucleate
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000114
@@ -2153,6 +1764,7 @@ name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: general_cell_types_upper_slim
+subset: human_reference_atlas
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
@@ -2160,6 +1772,7 @@ xref: CALOHA:TS-0415
xref: FBbt:00005144
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000126
@@ -2275,9 +1888,9 @@ name: mesenchymal stem cell
alt_id: CL:0002452
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -2285,7 +1898,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -2402,7 +2015,7 @@ name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
-synonym: "APC" RELATED abbreviation []
+synonym: "APC" RELATED OMO:0003000 []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
@@ -2465,14 +2078,12 @@ relationship: part_of UBERON:0006799 ! glandular epithelium
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000152
@@ -2878,7 +2489,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000188
@@ -2978,8 +2589,8 @@ id: CL:0000198
name: pain receptor cell
def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:D009619]
comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship
-synonym: "nociceptor" EXACT [] {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://meshb.nlm.nih.gov/record/ui?ui=D009619"}
-synonym: "nocireceptor" EXACT [] {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://www.thefreedictionary.com/nocireceptor"}
+synonym: "nociceptor" EXACT [] {seeAlso="https://meshb.nlm.nih.gov/record/ui?ui=D009619"}
+synonym: "nocireceptor" EXACT [] {seeAlso="https://www.thefreedictionary.com/nocireceptor"}
is_a: CL:0000006 ! neuronal receptor cell
[Term]
@@ -3092,7 +2703,7 @@ is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -3899,7 +3510,6 @@ name: tracheal epithelial cell
alt_id: CL:1000474
def: "An epithelial cell found in the trachea." [GOC:tfm]
comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'
-subset: human_reference_atlas
synonym: "tracheocyte" EXACT []
xref: FMA:74793
is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree
@@ -3907,7 +3517,6 @@ intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from CL:0000377 ! tracheoblast
relationship: part_of UBERON:0003126 ! trachea
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000308
@@ -4725,10 +4334,12 @@ relationship: bearer_of PATO:0001377 ! polyploid
id: CL:0000413
name: haploid cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm]
+subset: human_reference_atlas
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: bearer_of PATO:0001375 ! haploid
relationship: bearer_of PATO:0001375 ! haploid
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000414
@@ -4950,7 +4561,7 @@ synonym: "somatic stem cell" BROAD [doi:10.1016/j.devcel.2005.08.012]
xref: FBbt:00004903
is_a: CL:0000036 ! epithelial fate stem cell
is_a: CL:0000255 ! eukaryotic cell
-relationship: only_in_taxon NCBITaxon:6656 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/obophenotype/cell-ontology/issues/1943"} ! Arthropoda
+relationship: only_in_taxon NCBITaxon:6656 {IAO:0000233="https://github.com/obophenotype/cell-ontology/issues/1943"} ! Arthropoda
[Term]
id: CL:0000442
@@ -5712,9 +5323,10 @@ synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368]
synonym: "syntrophoblast cell" RELATED []
xref: FMA:83043
is_a: CL:0000228 ! multinucleate cell
-is_a: CL:2000060 ! placental villous trophoblast
+is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: bearer_of PATO:0001908 ! multinucleate
+relationship: part_of UBERON:0000371 ! syncytiotrophoblast
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/2100" xsd:string
@@ -5753,7 +5365,7 @@ name: primary neuron (sensu Teleostei)
def: "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." [doi:10.1242/dev.108.1.121, PMID:1842357]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000540 ! neuron
-relationship: only_in_taxon NCBITaxon:32443 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! Teleostei
+relationship: only_in_taxon NCBITaxon:32443 {IAO:0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! Teleostei
[Term]
id: CL:0000531
@@ -5789,7 +5401,7 @@ name: secondary neuron (sensu Teleostei)
def: "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages." [doi:10.1242/dev.108.1.121, PMID:1842357]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000540 ! neuron
-relationship: only_in_taxon NCBITaxon:32443 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! Teleostei
+relationship: only_in_taxon NCBITaxon:32443 {IAO:0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! Teleostei
[Term]
id: CL:0000536
@@ -5840,7 +5452,7 @@ is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata)
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000541
@@ -6000,7 +5612,7 @@ def: "OBSOLETE. A native cell that is part of some Metazoa." []
comment: https://github.com/obophenotype/cell-ontology/issues/2124
subset: ubprop:upper_level
synonym: "metazoan cell" EXACT []
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Animal_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Animal_cells.svg" xsd:anyURI
is_obsolete: true
replaced_by: CL:0000000
@@ -6159,9 +5771,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: human_reference_atlas
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
-synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
-synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
@@ -6286,8 +5898,8 @@ name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "AC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "ACs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "AC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "ACs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FMA:67766
@@ -6355,7 +5967,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -6366,7 +5977,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -6786,7 +6396,7 @@ is_a: CL:0000680 ! muscle precursor cell
id: CL:0000595
name: enucleate erythrocyte
def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm]
-synonym: "RBC" RELATED abbreviation []
+synonym: "RBC" RELATED OMO:0003000 []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
@@ -6922,9 +6532,9 @@ consider: PO:0009002
id: CL:0000611
name: eosinophil progenitor cell
comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76).
-synonym: "CFU-Eo" RELATED abbreviation []
+synonym: "CFU-Eo" RELATED OMO:0003000 []
synonym: "colony forming unit eosinophil" RELATED []
-synonym: "EoP" RELATED abbreviation [PMCID:PMC2212039, PMCID:PMC2626675]
+synonym: "EoP" RELATED OMO:0003000 [PMCID:PMC2212039, PMCID:PMC2626675]
synonym: "eosinophil stem cell" RELATED []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
@@ -7378,8 +6988,8 @@ name: folliculostellate cell
def: "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." [doi:10.23937/2572-407X.1510006, JB:jb, PMID:10495875, PMID:15961560]
comment: Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets. {xref="doi:10.23937/2572-407X.1510006", xref="PMID:34734454", xref="PMID:31620083", xref="PMID:18287078"}
synonym: "folliculo-stellate cell" EXACT [doi:10.23937/2572-407X.1510006]
-synonym: "FS cell" RELATED abbreviation [PMID:34734454]
-synonym: "FSC" RELATED abbreviation [doi:10.23937/2572-407X.1510006]
+synonym: "FS cell" RELATED OMO:0003000 [PMID:34734454]
+synonym: "FSC" RELATED OMO:0003000 [doi:10.23937/2572-407X.1510006]
synonym: "pituitary folliculostellate cell" EXACT [PMID:34734454]
synonym: "Sox2-positive stem cell" RELATED [PMID:34734454]
is_a: CL:0000512 ! paracrine cell
@@ -7999,6 +7609,7 @@ id: CL:0000706
name: choroid plexus epithelial cell
alt_id: CL:1000430
def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134]
+subset: human_reference_atlas
synonym: "choroid plexus cell" BROAD [DOI:10.1101/2022.10.12.511898]
synonym: "epithelial cell of choroid plexus" EXACT []
xref: FMA:70549
@@ -8008,6 +7619,7 @@ is_a: CL:0002319 ! neural cell
intersection_of: CL:0000065 ! ependymal cell
intersection_of: part_of UBERON:0001886 ! choroid plexus
relationship: part_of UBERON:0001886 ! choroid plexus
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-08-04T08:48:30Z" xsd:dateTime
[Term]
@@ -8287,8 +7899,8 @@ subset: eye_upper_slim
subset: human_reference_atlas
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
-synonym: "RGC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "RGCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
@@ -8314,7 +7926,9 @@ id: CL:0000743
name: hypertrophic chondrocyte
def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [GO_REF:0000034, PMID:15951842]
comment: is hypertrophic pathological or normal? and can it be described using a pato term?
+subset: human_reference_atlas
is_a: CL:0000138 ! chondrocyte
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000744
@@ -8328,8 +7942,8 @@ name: retina horizontal cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "HC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "HCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "HC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "HCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
is_a: CL:0000099 ! interneuron
@@ -8379,9 +7993,9 @@ name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "BC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "BCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "BPs" RELATED abbreviation [GSE137537]
+synonym: "BC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "BCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
+synonym: "BPs" RELATED OMO:0003004 [GSE137537]
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
@@ -8600,12 +8214,10 @@ relationship: has_part GO:0005634 ! nucleus
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
-subset: human_reference_atlas
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000767
@@ -8877,7 +8489,6 @@ id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
-subset: human_reference_atlas
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
@@ -8890,7 +8501,6 @@ intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleuki
intersection_of: develops_from CL:0000763 ! myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000763 ! myeloid cell
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000783
@@ -9198,7 +8808,7 @@ synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
-synonym: "gd T cell" RELATED abbreviation []
+synonym: "gd T cell" RELATED OMO:0003000 []
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
@@ -10366,6 +9976,7 @@ relationship: capable_of GO:0051767 ! nitric-oxide synthase biosynthetic process
id: CL:0000864
name: tissue-resident macrophage
def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654]
+subset: human_reference_atlas
synonym: "fixed macrophage" EXACT []
synonym: "resting histiocyte" EXACT []
xref: FMA:84642
@@ -10374,6 +9985,7 @@ is_a: CL:0000235 {is_inferred="true"} ! macrophage
intersection_of: CL:0000235 ! macrophage
intersection_of: part_of UBERON:0000479 ! tissue
relationship: part_of UBERON:0000479 ! tissue
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0000865
@@ -11622,9 +11234,10 @@ id: CL:0000936
name: early lymphoid progenitor
def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770]
comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative.
-synonym: "ELP" RELATED abbreviation []
-synonym: "GMLP" RELATED abbreviation [PMID:18371378]
-synonym: "LMPP" RELATED abbreviation []
+subset: human_reference_atlas
+synonym: "ELP" RELATED OMO:0003000 []
+synonym: "GMLP" RELATED OMO:0003000 [PMID:18371378]
+synonym: "LMPP" RELATED OMO:0003000 []
synonym: "lymphoid-primed multipotent progenitor" EXACT []
is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell
is_a: CL:0011026 ! progenitor cell
@@ -11638,6 +11251,7 @@ intersection_of: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte a
relationship: capable_of GO:0030098 ! lymphocyte differentiation
relationship: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part glycophorin-A
relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000002001 ! has plasma membrane part receptor-type tyrosine-protein kinase FLT3
relationship: RO:0002104 PR:000002065 ! has plasma membrane part mast/stem cell growth factor receptor
relationship: RO:0002104 PR:000002979 ! has plasma membrane part lymphocyte antigen 6A-2/6E-1
@@ -13570,9 +13184,9 @@ id: CL:0001059
name: common myeloid progenitor, CD34-positive
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566]
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -13720,10 +13334,10 @@ property_value: dcterms-date "2017-01-30T20:20:48Z" xsd:dateTime
id: CL:0001066
name: erythroid progenitor cell, mammalian
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464]
-synonym: "BFU-E" RELATED abbreviation []
+synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
-synonym: "CFU-E" RELATED abbreviation []
+synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
@@ -15405,7 +15019,7 @@ name: Feyrter cell
def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651]
synonym: "bronchiolar Kulchitsky cell" EXACT []
synonym: "Kultschitzky cell of bronchiole" EXACT []
-synonym: "P cell" RELATED abbreviation []
+synonym: "P cell" RELATED OMO:0003000 []
synonym: "respiratory enterochromaffin cell" EXACT []
xref: FMA:14118
is_a: CL:0000165 ! neuroendocrine cell
@@ -17021,7 +16635,7 @@ creation_date: 2010-08-30T01:27:48Z
id: CL:0002195
name: hepatic stem cell
def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363]
-synonym: "HpSC" RELATED abbreviation [PMID:18442648]
+synonym: "HpSC" RELATED OMO:0003000 [PMID:18442648]
xref: FMA:86577
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
intersection_of: CL:0000048 ! multi fate stem cell
@@ -17109,14 +16723,12 @@ id: CL:0002202
name: epithelial cell of tracheobronchial tree
alt_id: CL:1000407
def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm]
-subset: human_reference_atlas
xref: FMA:66816
is_a: CL:0002632 ! epithelial cell of lower respiratory tract
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0007196 ! tracheobronchial tree
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-09-02T02:09:14Z
[Term]
@@ -17593,7 +17205,6 @@ creation_date: 2010-09-07T02:25:18Z
id: CL:0002241
name: pulmonary interstitial fibroblast
def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm]
-subset: human_reference_atlas
synonym: "pulmonary myofibroblast" EXACT []
synonym: "pulmonary septal cell" EXACT []
xref: FMA:84467
@@ -17604,7 +17215,6 @@ intersection_of: part_of UBERON:0001004 ! respiratory system
intersection_of: part_of UBERON:0005169 ! interstitial tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001004 ! respiratory system
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-09-07T02:29:38Z
[Term]
@@ -18484,7 +18094,6 @@ creation_date: 2010-09-14T02:33:09Z
id: CL:0002313
name: endocrine-paracrine cell of prostate gland
def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm]
-subset: human_reference_atlas
synonym: "glandular cell of prostate" EXACT []
synonym: "neuro-epithelial cell of prostate gland" EXACT []
xref: CALOHA:TS-1280
@@ -18498,7 +18107,6 @@ intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: capable_of GO:0046879 ! hormone secretion
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002367 ! prostate gland
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-09-14T03:01:58Z
[Term]
@@ -18572,7 +18180,6 @@ id: CL:0002320
name: connective tissue cell
alt_id: CL:1000406
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -18581,7 +18188,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -18640,12 +18246,16 @@ creation_date: 2010-09-20T11:42:14Z
[Term]
id: CL:0002325
-name: mammary alveolar cell
+name: lactocyte
alt_id: CL:0002230
alt_id: CL:1000476
-def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771]
+def: "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland." [doi:10.1177/156482659601700404, GOC:tfm, PMID:19022771, PMID:28717367, PMID:35091553, PMID:35377806]
synonym: "epithelial cell of lactiferous gland" EXACT []
+synonym: "lactaction-associated mammary epithelial cell" EXACT [PMID:35091553]
+synonym: "lactation-derived mammary cell" EXACT [PMID:35091553]
+synonym: "LMC" RELATED OMO:0003000 [PMID:35091553]
synonym: "luminal cell of alveolus of lactiferous gland" EXACT []
+synonym: "mammary alveolar cell" BROAD [PMID:19022771]
synonym: "mammary alveolar epithelial cell" EXACT []
synonym: "mammary gland alveolar epithelial cell" EXACT []
xref: FMA:74506
@@ -18655,7 +18265,10 @@ is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell
is_a: CL:1001586 ! mammary gland glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0003214 ! mammary gland alveolus
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
+relationship: dc-contributor https://orcid.org/0000-0003-4361-817X
+relationship: develops_from CL:4033057 ! luminal adaptive secretory precursor cell of mammary gland
relationship: part_of UBERON:0003214 ! mammary gland alveolus
creation_date: 2010-09-20T01:30:57Z
@@ -18845,6 +18458,7 @@ creation_date: 2010-09-20T03:49:58Z
id: CL:0002343
name: decidual natural killer cell, human
def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965]
+subset: human_reference_atlas
synonym: "decidual NK cell" EXACT []
synonym: "dNK cell" EXACT []
is_a: CL:0000824 ! mature natural killer cell
@@ -18856,6 +18470,7 @@ intersection_of: RO:0015015 PR:000001024 ! has high plasma membrane amount neura
relationship: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: in_taxon NCBITaxon:9606 ! Homo sapiens
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002104 PR:000009766 ! has plasma membrane part galectin-1
relationship: RO:0015015 PR:000001024 ! has high plasma membrane amount neural cell adhesion molecule 1
creation_date: 2010-09-20T04:00:02Z
@@ -19163,7 +18778,7 @@ creation_date: 2010-09-22T10:47:28Z
id: CL:0002362
name: cerebellar granule cell precursor
def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [GOC:tfm, PMID:14745007]
-synonym: "GCP" RELATED abbreviation [doi:10.3389/fncir.2020.611841]
+synonym: "GCP" RELATED OMO:0003000 [doi:10.3389/fncir.2020.611841]
synonym: "granule cell precursor" BROAD [doi:10.3389/fncir.2020.611841]
synonym: "granule cell progenitor" BROAD [doi:10.3389/fncir.2020.611841]
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
@@ -20107,7 +19722,7 @@ id: CL:0002436
name: mature CD4 single-positive thymocyte
def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html]
subset: human_reference_atlas
-synonym: "T.4SP24-.Th" RELATED abbreviation []
+synonym: "T.4SP24-.Th" RELATED OMO:0003000 []
is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell
intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell
intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex
@@ -20324,8 +19939,8 @@ name: oligodendrocyte precursor cell
def: "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:10704434, PMID:11756508, PMID:20142420, PMID:2182078, PMID:24133281, PMID:9826671]
comment: This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). {xref="PMID:10704434", xref="ISBN:9780702028991", xref="PMID:2182078"}
subset: human_reference_atlas
-synonym: "O-2A/OPC" RELATED abbreviation [PMID:24133281]
-synonym: "O2A/OPC" RELATED abbreviation [PMID:11756508]
+synonym: "O-2A/OPC" RELATED OMO:0003000 [PMID:24133281]
+synonym: "O2A/OPC" RELATED OMO:0003000 [PMID:11756508]
synonym: "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" BROAD [PMID:2253328]
synonym: "oligodendrocyte/type-2 astrocyte progenitor cell" BROAD [PMID:24133281] {http://purl.org/dc/terms/contributor="https://orcid.org/0000-0002-0819-0473"}
xref: MESH:D000073637
@@ -20639,7 +20254,7 @@ creation_date: 2010-11-23T04:09:09Z
id: CL:0002476
name: bone marrow macrophage
def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
-synonym: "MF.BM" RELATED abbreviation []
+synonym: "MF.BM" RELATED OMO:0003000 []
xref: BTO:0004732
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: CL:1001610 ! bone marrow hematopoietic cell
@@ -21450,11 +21065,13 @@ creation_date: 2011-02-28T01:47:47Z
id: CL:0002541
name: chorionic membrane mesenchymal stem cell
def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm]
+subset: human_reference_atlas
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003124 ! chorion membrane
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0003124 ! chorion membrane
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-02-28T03:04:35Z
[Term]
@@ -21576,7 +21193,6 @@ creation_date: 2011-02-28T05:09:12Z
id: CL:0002553
name: fibroblast of lung
def: "A fibroblast that is part of lung." [GOC:tfm]
-subset: human_reference_atlas
xref: BTO:0000764
xref: CALOHA:TS-0575
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
@@ -21584,7 +21200,6 @@ intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002048 ! lung
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-02-28T05:11:03Z
[Term]
@@ -21624,20 +21239,24 @@ creation_date: 2011-02-28T05:19:48Z
id: CL:0002557
name: fibroblast of pulmonary artery
def: "A fibroblast of pulmonary artery." [GOC:tfm]
+subset: human_reference_atlas
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002012 ! pulmonary artery
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-02-28T05:22:27Z
[Term]
id: CL:0002558
name: fibroblast of villous mesenchyme
def: "A fibroblast that is part of villous mesenchyme." [GOC:tfm]
+subset: human_reference_atlas
is_a: CL:0000057 ! fibroblast
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0001987 ! placenta
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-02-28T05:24:28Z
[Term]
@@ -22011,12 +21630,14 @@ creation_date: 2011-03-06T05:01:20Z
id: CL:0002591
name: smooth muscle cell of the pulmonary artery
def: "A smooth muscle of the pulmonary artery." [GOC:tfm]
+subset: human_reference_atlas
xref: BTO:0003336
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002012 ! pulmonary artery
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2011-03-06T05:01:28Z
[Term]
@@ -22815,7 +22436,7 @@ name: cardioblast
def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164]
comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.
synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164]
-synonym: "CPC" RELATED abbreviation [PMID:19745164]
+synonym: "CPC" RELATED OMO:0003000 [PMID:19745164]
is_a: CL:0000048 ! multi fate stem cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-11T03:15:38Z
@@ -23007,7 +22628,8 @@ creation_date: 2011-09-27T11:59:01Z
[Term]
id: CL:0002681
name: kidney cortical cell
-is_a: CL:1000497 {is_inferred="true"} ! kidney cell
+def: "A cell that is part of a cortex of kidney." []
+is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: dc-contributor https://orcid.org/0000-0002-0956-8634
@@ -23794,7 +23416,7 @@ name: H1 horizontal cell
namespace: cell
def: "A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor." [PMID:8571130]
synonym: "A Horizontal Cell" EXACT []
-synonym: "H1" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "H1" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
is_a: CL:0000745 ! retina horizontal cell
relationship: CL:4030045 GO:0030424 ! lacks_part axon
property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string
@@ -23806,7 +23428,7 @@ name: H2 horizontal cell
namespace: cell
def: "A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor." [PMID:8571130]
synonym: "B Horizontal Cell" EXACT []
-synonym: "H2" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "H2" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
is_a: CL:0000745 ! retina horizontal cell
relationship: RO:0002120 GO:0044316 ! synapsed to cone cell pedicle
property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string
@@ -24261,7 +23883,9 @@ relationship: develops_from CL:0000333 ! migratory neural crest cell
id: CL:0005006
name: ionocyte
def: "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment." [PMID:17555741, PMID:19268451]
+subset: human_reference_atlas
is_a: CL:0000066 ! epithelial cell
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0005007
@@ -24317,7 +23941,7 @@ relationship: capable_of GO:0046717 ! acid secretion
id: CL:0005012
name: multi-ciliated epithelial cell
def: "A ciliated epithelial cell with many cilia." [CL:CVS]
-synonym: "MCC" RELATED abbreviation []
+synonym: "MCC" RELATED OMO:0003000 []
synonym: "multi-ciliated cell" BROAD []
synonym: "multiciliated cell" BROAD []
synonym: "multiciliated epithelial cell" EXACT []
@@ -24694,9 +24318,7 @@ relationship: part_of UBERON:0001003 ! skin epidermis
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
-subset: human_reference_atlas
is_a: CL:0000187 ! muscle cell
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0008001
@@ -24866,10 +24488,12 @@ relationship: RO:0002203 CL:0008003 ! develops into somatic muscle myotube
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:0008020
@@ -25120,7 +24744,7 @@ relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: present_in_taxon NCBITaxon:9443 ! Primates
relationship: RO:0002100 UBERON:0022315 ! has soma location primary motor cortex layer 5
relationship: RO:0002101 UBERON:0002707 ! fasciculates with corticospinal tract
-property_value: depicted_by "https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg" xsd:string
+property_value: http://xmlns.com/foaf/0.1/depiction "https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg" xsd:string
creation_date: 2020-09-28T09:52:58Z
[Term]
@@ -26191,6 +25815,7 @@ property_value: dcterms-date "2021-11-25T09:32:13Z" xsd:dateTime
id: CL:0009084
name: epithelial cell of endometrial gland
def: "An epithelial cell that is part of an endometrial gland." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
+subset: human_reference_atlas
subset: location_grouping
synonym: "endometrial glandular epithelial cell" EXACT []
xref: EFO:0010710
@@ -26199,6 +25824,7 @@ intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002451 ! endometrial gland
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0002451 ! endometrial gland
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2021-11-30T16:13:30Z" xsd:dateTime
[Term]
@@ -26396,12 +26022,14 @@ property_value: dcterms-date "2022-02-21T16:50:02Z" xsd:dateTime
id: CL:0009100
name: hepatic portal fibroblast
def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904]
+subset: human_reference_atlas
synonym: "portal fibroblast" BROAD []
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001279 ! portal triad
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0001279 ! portal triad
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-03-17T12:00:44Z" xsd:dateTime
[Term]
@@ -26477,7 +26105,7 @@ def: "A specialized fibroblast found in the medulla of lymph node." [https://orc
comment: Origin and phenotype of medullary reticular cells are less well understood in humans than in mice.
subset: human_reference_atlas
synonym: "lymph node medullary reticular cell" EXACT []
-synonym: "MedRC" RELATED abbreviation []
+synonym: "MedRC" RELATED OMO:0003000 []
synonym: "medullary reticular cell of lymph node" EXACT []
is_a: CL:0009102 ! lymph node fibroblastic reticular cell
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
@@ -26590,6 +26218,7 @@ property_value: dcterms-date "2022-03-24T10:18:12Z" xsd:dateTime
id: CL:0009115
name: lymph node lymphatic vessel endothelial cell
def: "An endothelial cell located in a lymph node lymphatic vessel." [https://orcid.org/0000-0001-7655-4833]
+subset: human_reference_atlas
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000029 ! lymph node
@@ -26597,6 +26226,7 @@ intersection_of: part_of UBERON:0001473 ! lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0001473 ! lymphatic vessel
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/1472" xsd:string
[Term]
@@ -27326,12 +26956,14 @@ relationship: part_of UBERON:0004872 ! splanchnic layer of lateral plate mesoder
id: CL:0017002
name: prostate neuroendocrine cell
def: "A neuroendocrine cell that is part of the prostate epithelium." [http://orcid.org/0000-0001-7772-9578, PMID:33842835]
+subset: human_reference_atlas
synonym: "neuroendocrine cell of prostate epithelium" EXACT []
synonym: "neuroendocrine cell of the prostate" EXACT []
is_a: CL:0000165 ! neuroendocrine cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0000428 ! prostate epithelium
relationship: part_of UBERON:0000428 ! prostate epithelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
created_by: http://orcid.org/0000-0003-2473-2313
[Term]
@@ -27556,12 +27188,14 @@ id: CL:0019003
name: tracheobronchial goblet cell
def: "Any goblet cell that is part of the tracheobronchial epithelium." []
subset: added_for_HCA
+subset: human_reference_atlas
synonym: "goblet cell of tracheobronchial tree" EXACT []
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0002370 ! respiratory goblet cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0007196 ! tracheobronchial tree
relationship: dc-contributor https://orcid.org/0000-0003-2034-601X
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2020-05-07T18:14:52Z" xsd:dateTime
[Term]
@@ -27819,13 +27453,11 @@ relationship: part_of UBERON:0005146 ! metanephric nephron tubule
[Term]
id: CL:1000143
name: lung goblet cell
-subset: human_reference_atlas
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002370 ! respiratory goblet cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000160 ! goblet cell
intersection_of: part_of UBERON:0002048 ! lung
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000147
@@ -27887,7 +27519,7 @@ id: CL:1000223
name: lung neuroendocrine cell
def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253]
subset: human_reference_atlas
-synonym: "PNEC" RELATED abbreviation [PMID:33355253]
+synonym: "PNEC" RELATED OMO:0003000 [PMID:33355253]
synonym: "pulmonary neuroendocrine cell" EXACT [PMID:33355253]
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000082 ! epithelial cell of lung
@@ -29678,12 +29310,14 @@ id: CL:1000486
name: basal cell of urothelium
def: "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role." [doi:10.1038/s41385-022-00565-0, GOC:tfm]
comment: It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells. {xref="doi:10.1038/s41385-022-00565-0"}
+subset: human_reference_atlas
synonym: "urothelial basal cell" EXACT [doi:10.1007/978-3-030-14366-4_8, doi:10.1111/cpr.13170]
xref: FMA:84150
is_a: CL:0000646 {is_inferred="true"} ! basal cell
is_a: CL:0000731 ! urothelial cell
intersection_of: CL:0000646 ! basal cell
intersection_of: part_of UBERON:0000365 ! urothelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000487
@@ -29760,12 +29394,14 @@ relationship: part_of UBERON:0002400 ! parietal pleura
id: CL:1000493
name: mesothelial cell of visceral pleura
def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm]
+subset: human_reference_atlas
xref: FMA:86739
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002401 ! visceral pleura
relationship: part_of UBERON:0002401 ! visceral pleura
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1000494
@@ -29797,6 +29433,7 @@ intersection_of: part_of UBERON:0002108 ! small intestine
[Term]
id: CL:1000497
name: kidney cell
+def: "A cell that is part of a kidney." []
xref: KUPO:0001010
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
@@ -29806,8 +29443,9 @@ relationship: part_of UBERON:0002113 ! kidney
[Term]
id: CL:1000500
name: kidney interstitial cell
+def: "A cell that is part of kidney interstitium." []
xref: KUPO:0001013
-is_a: CL:1000497 {is_inferred="true"} ! kidney cell
+is_a: CL:1000497 ! kidney cell
is_a: CL:4030031 ! interstitial cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005215 ! kidney interstitium
@@ -29816,8 +29454,9 @@ relationship: part_of UBERON:0005215 ! kidney interstitium
[Term]
id: CL:1000504
name: kidney medulla cell
+def: "A cell that is part of a renal medulla." []
xref: KUPO:0001017
-is_a: CL:1000497 {is_inferred="true"} ! kidney cell
+is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0000362 ! renal medulla
@@ -29825,8 +29464,9 @@ relationship: part_of UBERON:0000362 ! renal medulla
[Term]
id: CL:1000505
name: kidney pelvis cell
+def: "A cell that is part of a renal pelvis." []
xref: KUPO:0001018
-is_a: CL:1000497 {is_inferred="true"} ! kidney cell
+is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis
@@ -29834,8 +29474,9 @@ relationship: part_of UBERON:0001224 ! renal pelvis
[Term]
id: CL:1000507
name: kidney tubule cell
+def: "A cell that is part of a nephron tubule." []
xref: KUPO:0001020
-is_a: CL:1000497 {is_inferred="true"} ! kidney cell
+is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0001231 ! nephron tubule
@@ -29852,10 +29493,12 @@ relationship: part_of UBERON:0004188 ! glomerular epithelium
[Term]
id: CL:1000546
name: kidney medulla collecting duct epithelial cell
+def: "An epithelial cell that is part of a renal medulla collecting duct." []
xref: KUPO:0001060
+is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000504 ! kidney medulla cell
is_a: CL:1001225 ! kidney collecting duct cell
-intersection_of: CL:1000497 ! kidney cell
+intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005185 ! renal medulla collecting duct
relationship: part_of UBERON:0005185 ! renal medulla collecting duct
@@ -29864,29 +29507,32 @@ id: CL:1000547
name: kidney inner medulla collecting duct epithelial cell
def: "An epithelial cell that is part of some inner medullary collecting duct." []
xref: KUPO:0001061
+is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell
is_a: CL:1000617 ! kidney inner medulla cell
-is_a: CL:1001225 ! kidney collecting duct cell
-intersection_of: CL:1000497 ! kidney cell
+intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004205 ! inner medullary collecting duct
relationship: part_of UBERON:0004205 ! inner medullary collecting duct
[Term]
id: CL:1000548
name: kidney outer medulla collecting duct epithelial cell
+def: "An epithelial cell that is part of an outer medullary collecting duct." []
xref: KUPO:0001062
+is_a: CL:1000546 ! kidney medulla collecting duct epithelial cell
is_a: CL:1000616 ! kidney outer medulla cell
-is_a: CL:1001225 ! kidney collecting duct cell
-intersection_of: CL:1000497 ! kidney cell
+intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004204 ! outer medullary collecting duct
relationship: part_of UBERON:0004204 ! outer medullary collecting duct
[Term]
id: CL:1000549
name: kidney cortex collecting duct epithelial cell
+def: "An epithelial cell that is part of a cortical collecting duct." []
xref: KUPO:0001063
-is_a: CL:0002681 ! kidney cortical cell
+is_a: CL:0002584 ! renal cortical epithelial cell
+is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1001225 ! kidney collecting duct cell
-intersection_of: CL:1000497 ! kidney cell
+intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004203 ! cortical collecting duct
relationship: part_of UBERON:0004203 ! cortical collecting duct
@@ -30132,7 +29778,6 @@ id: CL:1000714
name: kidney cortex collecting duct principal cell
subset: human_reference_atlas
xref: KUPO:0001130
-is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
@@ -30144,7 +29789,6 @@ id: CL:1000715
name: kidney cortex collecting duct intercalated cell
subset: human_reference_atlas
xref: KUPO:0001131
-is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell
is_a: CL:1001432 ! kidney collecting duct intercalated cell
intersection_of: CL:0005010 ! renal intercalated cell
@@ -30364,12 +30008,14 @@ relationship: part_of UBERON:0001288 ! loop of Henle
[Term]
id: CL:1000979
name: ureter smooth muscle cell
+subset: human_reference_atlas
xref: KUPO:0001118
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0006855 ! muscular coat of ureter
relationship: part_of UBERON:0006855 ! muscular coat of ureter
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001005
@@ -30784,9 +30430,10 @@ intersection_of: part_of UBERON:0005168 ! renal interlobular vein
[Term]
id: CL:1001225
name: kidney collecting duct cell
+def: "A cell that is part of a collecting duct of renal tubule." []
xref: KUPO:0001012
xref: Wikipedia:Kidney_collecting_duct_cell
-is_a: CL:1000497 {is_inferred="true"} ! kidney cell
+is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule
@@ -31061,7 +30708,6 @@ replaced_by: CL:0002638
[Term]
id: CL:1001567
name: lung endothelial cell
-subset: human_reference_atlas
synonym: "endothelial cell of lung" RELATED []
synonym: "pulmonary vessel endothelial cell" RELATED []
is_a: CL:0000082 ! epithelial cell of lung
@@ -31069,17 +30715,18 @@ is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000102 ! lung vasculature
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001568
name: pulmonary artery endothelial cell
+subset: human_reference_atlas
synonym: "PAEC cell" RELATED [BTO:0001141]
xref: BTO:0001141
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0005317 ! pulmonary artery endothelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001569
@@ -31486,11 +31133,13 @@ relationship: part_of UBERON:0001332 ! prepuce of penis
id: CL:1001607
name: articular chondrocyte
def: "Chondrocyte forming the hyaline cartilage found in joints." [NPX:PDR]
+subset: human_reference_atlas
xref: CALOHA:TS-0056
is_a: CL:0000138 ! chondrocyte
intersection_of: CL:0000138 ! chondrocyte
intersection_of: part_of UBERON:0010996 ! articular cartilage of joint
relationship: part_of UBERON:0010996 ! articular cartilage of joint
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:1001608
@@ -32204,13 +31853,11 @@ id: CL:2000059
name: prostate gland microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a prostate gland." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=4400
-subset: human_reference_atlas
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: dc-contributor https://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0002367 ! prostate gland
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T17:46:27Z
[Term]
@@ -32235,11 +31882,13 @@ id: CL:2000061
name: placental amniotic mesenchymal stromal cell
def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140
+subset: human_reference_atlas
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: dc-contributor https://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0001987 ! placenta
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T17:51:11Z
[Term]
@@ -32247,14 +31896,12 @@ id: CL:2000062
name: placental villus capillary endothelial cell
def: "Any capillary endothelial cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.ncbi.nlm.nih.gov/books/NBK53245/
-subset: human_reference_atlas
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:0009092 ! endothelial cell of placenta
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0010005 ! placental labyrinth villous
relationship: dc-contributor https://www.wikidata.org/entity/Q35563349
relationship: part_of UBERON:0010005 ! placental labyrinth villous
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
creation_date: 2014-10-07T17:55:56Z
[Term]
@@ -32693,11 +32340,13 @@ creation_date: 2019-02-09T16:40:30Z
[Term]
id: CL:3000001
name: Hofbauer cell
-def: "Oval eosinophilic histiocytes with granules and vacuoles found in placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy." [GOC:CellBLAST, PMID:30429548]
-subset: human_reference_atlas
-is_a: CL:0000235 ! macrophage
+def: "A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin and is present throughout pregnancy." [GOC:CellBLAST, PMID:30429548, PMID:30498493, PMID:34745147, PMID:35438172]
+comment: Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve. {xref="PMID:30498493"}
+synonym: "HBC" RELATED OMO:0003000 []
+is_a: CL:0000864 ! tissue-resident macrophage
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://www.wikidata.org/entity/Q97529981
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+relationship: part_of UBERON:0001987 ! placenta
creation_date: 2019-02-18T19:41:20Z
[Term]
@@ -32913,6 +32562,7 @@ id: CL:4023013
name: corticothalamic-projecting glutamatergic cortical neuron
def: "A glutamatergic neuron located in the cerebral cortex that projects to the thalamus." [DOI:10.1101/2020.10.19.343129]
subset: BDS_subset
+subset: human_reference_atlas
synonym: "CT projecting neuron" EXACT []
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0010012 ! cerebral cortex neuron
@@ -32921,6 +32571,7 @@ intersection_of: bearer_of PATO:0070029 ! corticothalamic projecting
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: bearer_of PATO:0070029 ! corticothalamic projecting
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: IAO:0000028 "CT glut" xsd:string
[Term]
@@ -33077,9 +32728,9 @@ relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
id: CL:4023026
name: direct pathway medium spiny neuron
def: "A medium spiny neuron that expresses dopamine type 1 receptors and projects to the globus pallidus internus or the substantia nigra pars reticulata." [PMID:34727523, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850]
-synonym: "D1-MSN" EXACT abbreviation [PMID:34727523]
+synonym: "D1-MSN" EXACT OMO:0003000 [PMID:34727523]
synonym: "dopamine 1 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596]
-synonym: "dSPN" EXACT abbreviation [PMID:30096299]
+synonym: "dSPN" EXACT OMO:0003000 [PMID:30096299]
is_a: CL:1001474 ! medium spiny neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor
@@ -33115,9 +32766,9 @@ property_value: IAO:0000028 "L5 non-Martinotti sst interneuron (Mus)" xsd:string
id: CL:4023029
name: indirect pathway medium spiny neuron
def: "A medium spiny neuron that expresses dopamine type 2 receptors and projects to the external globus pallidus." [PMID:34727523, WikipediaVersioned:Medium_spiny_neuron&oldid=1109726850]
-synonym: "D2-MSN" EXACT abbreviation [PMID:34727523]
+synonym: "D2-MSN" EXACT OMO:0003000 [PMID:34727523]
synonym: "dopamine 2 medium spiny neuron" EXACT [https://orcid.org/0000-0001-7258-9596]
-synonym: "iSPN" EXACT abbreviation [PMID:30096299]
+synonym: "iSPN" EXACT OMO:0003000 [PMID:30096299]
is_a: CL:1001474 ! medium spiny neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor
@@ -33231,7 +32882,7 @@ name: L5 extratelencephalic projecting glutamatergic cortical neuron
def: "A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics." [DOI:10.1101/2020.10.19.343129]
subset: BDS_subset
synonym: "burst-firing layer 5 neuron" EXACT [DOI:10.3389/fncel.2011.00001]
-synonym: "L5b neuron" RELATED abbreviation [DOI:10.1016/j.neuron.2011.07.029]
+synonym: "L5b neuron" RELATED OMO:0003000 [DOI:10.1016/j.neuron.2011.07.029]
synonym: "pyramidal tract (PT) neuron" NARROW [DOI:10.1038/nrn3469]
synonym: "Pyramidal tract-like (PT-l)" EXACT [DOI:10.1016/j.cell.2019.09.023] {comment="pyramidal tract-like is used because, unlike pyramidal tract neurons in the motor cortex, neurons in the structures like the auditory cortex do not project to the spinal cord."}
synonym: "subcerebral projection (SCPN) neuron" BROAD [DOI:10.1016/j.neuron.2005.08.030]
@@ -33320,13 +32971,11 @@ def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in
subset: BDS_subset
synonym: "L2/3 IT M1" EXACT []
synonym: "L2/3 IT MOp" EXACT []
-is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
-intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+is_a: CL:4030059 ! L2/3 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4030059 ! L2/3 intratelencephalic projecting glutamatergic neuron
intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-intersection_of: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-relationship: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III
property_value: IAO:0000028 "L2/3 IT glut MOp" xsd:string
[Term]
@@ -33337,13 +32986,11 @@ subset: BDS_subset
synonym: "L4/5 IT M1" EXACT []
synonym: "L4/5 IT MOp" EXACT []
xref: ILX:0770174
-is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
-intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+is_a: CL:4030062 ! L4/5 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4030062 ! L4/5 intratelencephalic projecting glutamatergic neuron
intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-intersection_of: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-relationship: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V
property_value: IAO:0000028 "L4/5 IT glut MOp" xsd:string
[Term]
@@ -33354,13 +33001,11 @@ subset: BDS_subset
synonym: "L5 IT M1" EXACT []
synonym: "L5 IT MOp" EXACT []
xref: ILX:0770157
-is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
-intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+is_a: CL:4030064 ! L5 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4030064 ! L5 intratelencephalic projecting glutamatergic neuron
intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-intersection_of: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
property_value: IAO:0000028 "L5 IT glut MOp" xsd:string
[Term]
@@ -33372,13 +33017,11 @@ synonym: "L6 IT M1" EXACT []
synonym: "L6 IT MOp" EXACT []
xref: ILX:0770158
is_a: CL:2000049 ! primary motor cortex pyramidal cell
-is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
-intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+is_a: CL:4030065 ! L6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4030065 ! L6 intratelencephalic projecting glutamatergic neuron
intersection_of: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
-intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
relationship: bearer_of PATO:0070019 ! untufted pyramidal morphology
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
-relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
property_value: IAO:0000028 "L6 IT glut MOp" xsd:string
[Term]
@@ -33478,7 +33121,7 @@ def: "An oligodendrocyte precursor cell that is committed to differentiate." [PM
comment: COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from. {xref="PMID:27284195"}
subset: human_reference_atlas
synonym: "committed oligodendrocyte precursor" EXACT []
-synonym: "COP" EXACT abbreviation []
+synonym: "COP" EXACT OMO:0003000 []
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell
@@ -33649,9 +33292,7 @@ id: CL:4023073
name: obsolete choroid plexus cell
def: "OBSOLETE. A cell that is part of the choroid plexus." [DOI:10.1101/2022.10.12.511898]
comment: https://github.com/obophenotype/cell-ontology/issues/2043
-subset: human_reference_atlas
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
-relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
is_obsolete: true
replaced_by: CL:0000706
@@ -33702,7 +33343,7 @@ id: CL:4023077
name: bitufted neuron
def: "A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma." [PMID:18568015]
subset: BDS_subset
-xref: ILX:0777212 {http://purl.obolibrary.org/obo/IAO_0000116="Interlex cross reference refers specifically to Markram 2015 rat bitufted cell."}
+xref: ILX:0777212 {IAO:0000116="Interlex cross reference refers specifically to Markram 2015 rat bitufted cell."}
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: bearer_of PATO:0070012 ! bitufted cell morphology
@@ -33757,12 +33398,13 @@ property_value: IAO:0000028 "inverted L6 IT glut MOp" xsd:string
[Term]
id: CL:4023083
name: chandelier cell
-def: "An interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling a chandelier. Chandelier cells can be multipolar or bitufted." [PMID:15378039, PMID:27199673]
+def: "A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted." [PMID:15378039, PMID:27199673]
subset: BDS_subset
-synonym: "ChC" EXACT [PMID:15378039]
-xref: ILX:0777213 {http://purl.obolibrary.org/obo/IAO_0000116="Interlex cross reference refers specifically to Markram 2015 rat chandelier cell."}
-is_a: CL:0000099 ! interneuron
-intersection_of: CL:0000099 ! interneuron
+synonym: "axo-axonic cell" BROAD [PMID:27199673, PMID:33862423]
+synonym: "ChC" RELATED OMO:0003000 [PMID:15378039]
+xref: ILX:0777213 {IAO:0000116="Interlex cross reference refers specifically to Markram 2015 rat chandelier cell."}
+is_a: CL:0011005 ! GABAergic interneuron
+intersection_of: CL:0011005 ! GABAergic interneuron
intersection_of: bearer_of PATO:0070011 ! chandelier cell morphology
relationship: bearer_of PATO:0070011 ! chandelier cell morphology
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
@@ -33884,8 +33526,8 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
id: CL:4023097
name: arachnoid barrier cell
def: "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." [PMID:23298861]
-synonym: "AB cell" RELATED abbreviation [PMID:23298861]
-synonym: "ABC" RELATED abbreviation [PMID:30096314]
+synonym: "AB cell" RELATED OMO:0003000 [PMID:23298861]
+synonym: "ABC" RELATED OMO:0003000 [PMID:30096314]
is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: part_of UBERON:0000437 ! arachnoid barrier layer
@@ -34150,7 +33792,7 @@ id: CL:4023122
name: oxytocin receptor sst GABAergic cortical interneuron
def: "An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin." [PMID:25303526]
comment: These cells were first identified in mouse. {xref="PMID:25303526"}
-synonym: "OxtrINs" RELATED abbreviation [PMID:25303526]
+synonym: "OxtrINs" RELATED OMO:0003000 [PMID:25303526]
is_a: CL:4023017 ! sst GABAergic cortical interneuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:10090 {xref="PMID:25303526"} ! Mus musculus
@@ -34309,7 +33951,7 @@ relationship: RO:0013001 UBERON:0002128 ! has synaptic IO in region superior oli
id: CL:4023163
name: spherical bushy cell
def: "A bushy cell that receives only few large excitatory endbulb synapses from auditory nerves. Spherical bush cells give excitatory input to the lateral and medial parts of the superior olive." [PMID:31881018, WikipediaVersioned:Bushy_cell&oldid=879061753]
-synonym: "SBC" EXACT abbreviation [PMID:31881018]
+synonym: "SBC" RELATED OMO:0003000 [PMID:31881018]
is_a: CL:4023162 ! bushy cell
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
@@ -34317,7 +33959,7 @@ relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
id: CL:4023164
name: globular bushy cell
def: "A bushy cell that receives a large number of medium-sized synapses, called modified endbulbs. Globular bushy cells extend to the superior olive on both sides of the brainstem where they give input to the bipolar neurons." [PMID:31881018, WikipediaVersioned:Bushy_cell&oldid=879061753]
-synonym: "GBC" EXACT abbreviation [PMID:31881018]
+synonym: "GBC" EXACT OMO:0003000 [PMID:31881018]
is_a: CL:4023162 ! bushy cell
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
@@ -34426,9 +34068,9 @@ id: CL:4028002
name: alveolar capillary type 1 endothelial cell
def: "An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells." [PMID:31233341, PMID:32059772, PMID:32059779, PMID:32091393, PMID:33057196, PMID:33705684]
subset: human_reference_atlas
-synonym: "CAP1" RELATED [] {comment="abbreviation"}
+synonym: "CAP1" RELATED OMO:0003000 []
synonym: "capillary 1 cell" BROAD []
-synonym: "gCAP" RELATED [PMID:33057196] {comment="abbreviation"}
+synonym: "gCAP" RELATED OMO:0003000 [PMID:33057196]
synonym: "general capillary cell" BROAD [PMID:33057196]
is_a: CL:0010003 ! epithelial cell of alveolus of lung
is_a: CL:4028001 ! pulmonary capillary endothelial cell
@@ -34441,7 +34083,7 @@ id: CL:4028003
name: alveolar capillary type 2 endothelial cell
def: "An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)." [PMID:31233341, PMID:32059772, PMID:32059779, PMID:32091393, PMID:33057196]
subset: human_reference_atlas
-synonym: "aCAP" RELATED abbreviation []
+synonym: "aCAP" RELATED OMO:0003000 []
synonym: "aerocyte" BROAD [PMID:33057196]
synonym: "alveolar capillary cell" BROAD []
synonym: "capillary 2 cell" BROAD []
@@ -34458,7 +34100,7 @@ id: CL:4028004
name: alveolar type 1 fibroblast cell
def: "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." [PMID:22268140, PMID:26706109, PMID:28886382, PMID:29489752, PMID:30675802, PMID:33624948, PMID:33707239, PMID:9074756]
subset: human_reference_atlas
-synonym: "AF1" RELATED abbreviation []
+synonym: "AF1" RELATED OMO:0003000 []
synonym: "alveolar fibroblast" BROAD []
synonym: "alveolar fibroblast 1" BROAD []
synonym: "lipid interstitial cell" BROAD []
@@ -34481,9 +34123,9 @@ name: alveolar type 2 fibroblast cell
def: "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." [PMID:26706109, PMID:28886382, PMID:29752282, PMID:30675802, PMID:33208946, PMID:33624948]
subset: human_reference_atlas
synonym: "adventitial fibroblast" BROAD []
-synonym: "AF2" RELATED abbreviation []
+synonym: "AF2" RELATED OMO:0003000 []
synonym: "alveolar fibroblast" BROAD []
-synonym: "MANC" RELATED abbreviation []
+synonym: "MANC" RELATED OMO:0003000 []
synonym: "matrix fibroblast 2" BROAD []
synonym: "mesenchymal alveolar niche cell" BROAD []
synonym: "type-2 associated stromal cell" BROAD []
@@ -34598,21 +34240,25 @@ id: CL:4030006
name: fallopian tube secretory epithelial cell
def: "An epithelial cell that is part of the fallopian tube epithelium that secretes mucous fluid and oviduct-specific products through the stimulation of estrogen and luteinizing hormone. The fallopian tube secretory cell has approximately the same height as the ciliated cell and is usually a more narrow columnar cell. The nucleus is ovoid and perpendicular to the long axis of the cell. The chromatin is more dense and the nucleolus smaller than that seen in the ciliated cell." [https://doi.org/10.1186/1477-7827-7-129, https://doi.org/10.3390/cells8080933, https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube] {http://purl.org/dc/terms/contributor="https://orcid.org/0000-0002-0819-0473"}
comment: The other cell types of the fallopian tube epithelium include the ciliated cell and the intercalary cell, or peg cell. The fallopian tube secretory epithelial cell type has been implicated as a source of high-grade serous ovarian carcinoma. {xref="https://doi.org/10.1016/j.ccr.2013.10.013", xref="https://www.proteinatlas.org/learn/dictionary/normal/fallopian+tube"}
+subset: human_reference_atlas
synonym: "oviduct secretory epithelial cell" BROAD []
synonym: "uterine tube secretory epithelial cell" EXACT []
is_a: CL:1001591 ! oviduct glandular cell
relationship: dc-contributor https://orcid.org/0000-0002-1773-2692
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-03-03T10:39:31Z" xsd:dateTime
[Term]
id: CL:4030007
name: fallopian tube ciliated cell
def: "An epithelial ciliated cell that is part of the fallopian tube. This cell type is found mainly on the apex of the mucosal folds and contributes, together with peristaltic contractions, to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube. A fallopian tube ciliated cell has a columnar shape and contains an oval or round nucleus, often located perpendicular or parallel to the long axis of the cell." [PMID:16565155] {http://purl.org/dc/terms/contributor="https://orcid.org/0000-0002-0819-0473"}
+subset: human_reference_atlas
synonym: "oviduct ciliated cell" BROAD []
synonym: "uterine tube ciliated epithelial cell" EXACT []
is_a: CL:0005012 ! multi-ciliated epithelial cell
relationship: dc-contributor https://orcid.org/0000-0002-1773-2692
relationship: part_of UBERON:0007589 ! ciliated columnar oviduct epithelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-03-08T12:40:19Z" xsd:dateTime
[Term]
@@ -34747,12 +34393,10 @@ name: kidney connecting tubule principal cell
def: "A renal principal cell located in the connecting tubule." [http://orcid.org/0000-0003-2804-127X, PMID:27582101, PMID:31249312]
subset: human_reference_atlas
is_a: CL:0005009 ! renal principal cell
-is_a: CL:1000449 ! epithelial cell of nephron
-is_a: CL:1000507 ! kidney tubule cell
+is_a: CL:1000768 ! kidney connecting tubule epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0005097 ! renal connecting tubule
relationship: dc-contributor https://orcid.org/0000-0002-1773-2692
-relationship: part_of UBERON:0005097 ! renal connecting tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-06-27T15:25:10Z" xsd:dateTime
@@ -34923,9 +34567,10 @@ id: CL:4030032
name: valve interstitial cell
def: "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [https://doi.org/10.1098/rsif.2017.0580, https://doi.org/10.1161/ATVBAHA.120.314789, https://doi.org/10.1161/JAHA.117.006339, https://doi.org/10.2353/ajpath.2007.070251, https://orcid.org/0000-0001-7655-4833, PMID:25311230]
comment: Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis). {xref="PMID:25311230"}
+subset: human_reference_atlas
synonym: "cardiac valve interstitial cell" EXACT []
synonym: "valvular interstitial cell" EXACT [PMID:25311230]
-synonym: "VIC" EXACT abbreviation [PMID:25311230, PMID:30796046]
+synonym: "VIC" EXACT OMO:0003000 [PMID:25311230, PMID:30796046]
is_a: CL:0000151 ! secretory cell
is_a: CL:1000147 ! cardiac valve cell
is_a: CL:4030031 ! interstitial cell
@@ -34933,6 +34578,7 @@ intersection_of: CL:4030031 ! interstitial cell
intersection_of: part_of UBERON:0000946 ! cardiac valve
relationship: capable_of GO:0070278 ! extracellular matrix constituent secretion
relationship: dc-contributor https://orcid.org/0000-0002-1773-2692
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2022-12-06T14:18:45Z" xsd:dateTime
[Term]
@@ -34941,7 +34587,7 @@ name: valve endothelial cell
def: "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes." [PMID:25311230]
comment: At least in some mammalian species, a valve endothelial cell expresses CD31. Valve endothelial cells can undergo an endothelial to mesenchymal transition to acquire a fibroblast or myofibroblast phenotype that leads to changes in the microenvironmental signals and facilitates tissue regeneration. {xref="PMID:25311230"}
synonym: "valvular endothelial cell" EXACT [PMID:25311230]
-synonym: "VEC" EXACT abbreviation [PMID:25311230, PMID:30796046]
+synonym: "VEC" EXACT OMO:0003000 [PMID:25311230, PMID:30796046]
is_a: CL:0010008 ! cardiac endothelial cell
is_a: CL:1000147 ! cardiac valve cell
intersection_of: CL:0000115 ! endothelial cell
@@ -34964,7 +34610,7 @@ property_value: dcterms-date "2023-01-25T11:06:01Z" xsd:dateTime
id: CL:4030035
name: dental pulp stem cell
def: "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation." [DOI:10.1177/154405910208100806, https://orcid.org/0000-0002-2825-0621]
-synonym: "DPSC" EXACT abbreviation []
+synonym: "DPSC" EXACT OMO:0003000 []
is_a: CL:0000034 ! stem cell
is_a: CL:0002148 ! dental pulp cell
intersection_of: CL:0000034 ! stem cell
@@ -35012,7 +34658,7 @@ id: CL:4030039
name: von Economo neuron
def: "An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4." [DOI:10.1007/BF02970950, DOI:10.1101/2022.10.12.511898, PMID:32127543]
comment: In humans, a von Economo neuron is restricted to layer 5 of the anterior cingulate, frontoinsular, and medial frontopolar regions of cerebral cortex, while in some other species it is also found in the frontal and occipital poles and may not be restricted to layer 5. {xref="PMID:32127543"}
-synonym: "VEN" RELATED abbreviation [PMID:32127543]
+synonym: "VEN" RELATED OMO:0003000 [PMID:32127543]
is_a: CL:4023009 ! extratelencephalic-projecting glutamatergic cortical neuron
relationship: bearer_of PATO:0070006 ! cortical bipolar morphology
property_value: dcterms-date "2023-05-25T07:29:21Z" xsd:dateTime
@@ -35054,9 +34700,9 @@ id: CL:4030043
name: matrix D1 medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D1-matrix" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "D1M" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "matrix D1-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1-matrix" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1M" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "matrix D1-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:4023026 ! direct pathway medium spiny neuron
property_value: dcterms-date "2023-06-02T14:05:03Z" xsd:dateTime
@@ -35065,9 +34711,9 @@ id: CL:4030047
name: matrix D2 medium spiny neuron
def: "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D2-matrix" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "D2M" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "matrix D2-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D2-matrix" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "D2M" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "matrix D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:4023029 ! indirect pathway medium spiny neuron
property_value: dcterms-date "2023-06-02T14:40:25Z" xsd:dateTime
@@ -35076,10 +34722,10 @@ id: CL:4030048
name: striosomal D1 medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D1-striosome" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015]
-synonym: "D1S" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1-striosome" RELATED OMO:0003000 [DOI:10.1016/j.cub.2021.10.015]
+synonym: "D1S" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
synonym: "striosome D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
-synonym: "striosome D1-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "striosome D1-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:4023026 ! direct pathway medium spiny neuron
property_value: dcterms-date "2023-06-02T14:50:43Z" xsd:dateTime
@@ -35088,10 +34734,10 @@ id: CL:4030049
name: striosomal D2 medium spiny neuron
def: "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D2-striosome" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "D2S" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D2-striosome" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "D2S" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
synonym: "striosome D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
-synonym: "striosome D2-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "striosome D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:4023029 ! indirect pathway medium spiny neuron
property_value: dcterms-date "2023-06-02T15:03:08Z" xsd:dateTime
@@ -35100,10 +34746,10 @@ id: CL:4030050
name: D1/D2-hybrid medium spiny neuron
def: "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." [doi:10.1016/j.cub.2021.10.015]
comment: It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D1/2" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "D1/D2 hybrid" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "D1/D2-hybrid MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "hybrid D1/2 cell type" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1/2" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1/D2 hybrid" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1/D2-hybrid MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "hybrid D1/2 cell type" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005382 ! has soma location dorsal striatum
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor
@@ -35115,9 +34761,9 @@ id: CL:4030051
name: nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D1Sh" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1Sh" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
synonym: "NAc shell and OT D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
-synonym: "NAc shell and OT D1-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "NAc shell and OT D1-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor
@@ -35128,10 +34774,10 @@ id: CL:4030052
name: nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron
def: "A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D2Sh" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D2Sh" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
synonym: "NAc shell and OT D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
-synonym: "NAc shell and OT D2-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
-synonym: "nucleus accumbens shell and olfactory tubercle D2-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "NAc shell and OT D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
+synonym: "nucleus accumbens shell and olfactory tubercle D2-MSN" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum
relationship: RO:0002292 PR:000001177 ! expresses D(2) dopamine receptor
@@ -35142,7 +34788,7 @@ id: CL:4030053
name: Island of Calleja granule cell
def: "A DRD1-expressing, medium spiny neuron-like granule cell that is part of an Island of Calleja." [doi:10.1016/j.cub.2021.10.015]
comment: In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D1-ICj" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1-ICj" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
is_a: CL:0000120 ! granule cell
is_a: CL:0002613 ! striatum neuron
relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor
@@ -35153,7 +34799,7 @@ id: CL:4030054
name: RXFP1-positive interface island D1-medium spiny neuron
def: "A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei." [doi:10.1016/j.cub.2021.10.015]
comment: Regarding the abbreviation D1-NUDAP, NUDAP stands for "neurochemically unique domains in the accumbens and putamen". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions. {xref="doi:10.1016/j.cub.2021.10.015"}
-synonym: "D1-NUDAP" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015]
+synonym: "D1-NUDAP" RELATED OMO:0003000 [doi:10.1016/j.cub.2021.10.015]
synonym: "RXFP1-positive island D1-medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015]
is_a: CL:1001474 ! medium spiny neuron
relationship: RO:0002100 UBERON:0005403 ! has soma location ventral striatum
@@ -35166,9 +34812,11 @@ id: CL:4030055
name: intermediate cell of urothelium
def: "A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes." [doi:10.1038/s41385-022-00565-0]
comment: It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells. {xref="doi:10.1038/s41385-022-00565-0"}
+subset: human_reference_atlas
synonym: "urothelial intermediate cell" EXACT [doi:10.1007/978-3-030-14366-4_8]
xref: FMA:84155
is_a: CL:0000731 ! urothelial cell
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dc-contributor "https://orcid.org/0000-0003-3065-9183" xsd:string
property_value: dcterms-date "2023-06-16T07:53:43Z" xsd:dateTime
@@ -35177,10 +34825,12 @@ id: CL:4030056
name: umbrella cell of urothelium
def: "A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled." [doi:10.1038/s41385-022-00565-0]
comment: Umbrella cells are attached to sub-superficial cell layers via desmosomes, while tight junctions localized between superficial cells aid in forming a high-resistance barrier function. Another distinguishing feature of an umbrella cell type is the presence of subapical discoidal/fusiform-shaped vesicles contributing to the plasticity in urothelial cell surface area through a regulated process of endocytosis/exocytosis. It has been noted in at least some mammalian species that the urothelial umbrella cell type expresses UPK1A, UPK1B, UPK2 and UPK3A. Unlike intermediate and basal cells of the urothelium, CK17 is reported to be completely absent and p63 not expressed in umbrella cells. {xref="doi:10.1038/s41385-022-00565-0"}
+subset: human_reference_atlas
synonym: "facet cell of urothelium" EXACT [doi:10.1038/s41385-022-00565-0]
synonym: "superficial cell of urothelium" EXACT [doi:10.1038/s41385-022-00565-0]
xref: FMA:84149
is_a: CL:0000731 ! urothelial cell
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dc-contributor "https://orcid.org/0000-0003-3065-9183" xsd:string
property_value: dcterms-date "2023-06-16T07:59:43Z" xsd:dateTime
@@ -35189,13 +34839,126 @@ id: CL:4030057
name: eccentric medium spiny neuron
def: "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei." [doi:10.1016/j.cell.2018.07.028, doi:10.1101/2022.10.12.511898]
comment: The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type. {xref="doi:10.1101/2022.10.12.511898", xref="doi:10.1016/j.cell.2018.07.028"}
-synonym: "eccentric MSN" RELATED abbreviation [doi:10.1101/2022.10.12.511898]
+synonym: "eccentric MSN" RELATED OMO:0003000 [doi:10.1101/2022.10.12.511898]
synonym: "eccentric spiny projection neuron" EXACT [doi:10.1016/j.cell.2018.07.028]
-synonym: "eccentric SPN" RELATED abbreviation [doi:10.1016/j.cell.2018.07.028]
-synonym: "eSPN" RELATED abbreviation [doi:10.1016/j.cell.2018.07.028]
+synonym: "eccentric SPN" RELATED OMO:0003000 [doi:10.1016/j.cell.2018.07.028]
+synonym: "eSPN" RELATED OMO:0003000 [doi:10.1016/j.cell.2018.07.028]
is_a: CL:1001474 ! medium spiny neuron
property_value: dcterms-date "2023-06-23T14:59:36Z" xsd:dateTime
+[Term]
+id: CL:4030058
+name: TCR-positive macrophage
+def: "A macrophage that expresses the T cell receptor complex at the cell surface." [https://orcid.org/0000-0001-9990-8331, PMID:26074923]
+synonym: "T cell receptor positive macrophage" EXACT [PMID:26074923]
+synonym: "TCR+ macrophage" EXACT [PMID:26074923]
+synonym: "TCR.macs" RELATED [PMID:37500727] {synonymtypedef="OMO:0003000"}
+is_a: CL:0000235 ! macrophage
+is_a: PR:000050567 ! protein-containing material entity
+intersection_of: CL:0000235 ! macrophage
+intersection_of: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex
+relationship: dc-contributor https://orcid.org/0000-0003-3308-6245
+relationship: RO:0002104 GO:0042101 ! has plasma membrane part T cell receptor complex
+property_value: dcterms-date "2023-09-26T12:27:14Z" xsd:dateTime
+
+[Term]
+id: CL:4030059
+name: L2/3 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3." [PMID:34004146, PMID:37292694]
+synonym: "L2/3 IT" RELATED OMO:0003000 [PMID:34004146]
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III
+property_value: dcterms-date "2023-10-10T14:10:21Z" xsd:dateTime
+
+[Term]
+id: CL:4030060
+name: L2 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2." [PMID:34004146]
+synonym: "L2 IT" RELATED OMO:0003000 [PMID:34004146]
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:0005391 ! has soma location cortical layer II
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:0005391 ! has soma location cortical layer II
+property_value: dcterms-date "2023-10-10T14:10:36Z" xsd:dateTime
+
+[Term]
+id: CL:4030061
+name: L3 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3." [PMID:34004146]
+synonym: "L3 IT" RELATED OMO:0003000 [PMID:34004146]
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:0005392 ! has soma location cortical layer III
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:0005392 ! has soma location cortical layer III
+property_value: dcterms-date "2023-10-10T14:10:47Z" xsd:dateTime
+
+[Term]
+id: CL:4030062
+name: L4/5 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5." [PMID:34004146]
+synonym: "L4/5 IT" RELATED OMO:0003000 [PMID:34004146]
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V
+property_value: dcterms-date "2023-10-10T14:11:04Z" xsd:dateTime
+
+[Term]
+id: CL:4030063
+name: L4 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 4." [PMID:37292694]
+synonym: "L4 IT" RELATED OMO:0003000 [PMID:37292694]
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:0005393 ! has soma location cortical layer IV
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:0005393 ! has soma location cortical layer IV
+property_value: dcterms-date "2023-10-10T14:11:25Z" xsd:dateTime
+
+[Term]
+id: CL:4030064
+name: L5 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5." [PMID:37292694, PMID:37609206]
+synonym: "L5 IT" RELATED [PMID:37292694] {synonymtypedef="OMO:0003000"}
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
+property_value: dcterms-date "2023-10-10T14:11:59Z" xsd:dateTime
+
+[Term]
+id: CL:4030065
+name: L6 intratelencephalic projecting glutamatergic neuron
+def: "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 6." [PMID:37292694, PMID:37609206]
+synonym: "L6 IT" RELATED OMO:0003000 [PMID:37292694]
+is_a: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: CL:4023040 ! L2/3-6 intratelencephalic projecting glutamatergic neuron
+intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
+relationship: dc-contributor https://orcid.org/0000-0003-4389-9821
+relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
+property_value: dcterms-date "2023-10-10T14:12:23Z" xsd:dateTime
+
+[Term]
+id: CL:4030066
+name: ureteric bud cell
+def: "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." [PMID:17133361, PMID:24183650, PMID:9374839]
+synonym: "UB cell" RELATED OMO:0003000 [PMID:24183650]
+is_a: CL:0000068 ! duct epithelial cell
+is_a: CL:0002518 ! kidney epithelial cell
+intersection_of: CL:0000066 ! epithelial cell
+intersection_of: part_of UBERON:0000084 ! ureteric bud
+relationship: part_of UBERON:0000084 ! ureteric bud
+relationship: participates_in GO:2001013 {xref="PMID:9374839"} ! epithelial cell proliferation involved in renal tubule morphogenesis
+property_value: dc-contributor "https://orcid.org/0000-0002-1425-877X" xsd:string
+property_value: dcterms-date "2023-10-13T11:22:42Z" xsd:dateTime
+
[Term]
id: CL:4032000
name: club-like cell of the urethral epithelium
@@ -35284,12 +35047,14 @@ relationship: part_of UBERON:0012419 ! taenia coli
id: CL:4033005
name: serous secreting cell of bronchus submucosal gland
def: "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." [PMID:5487122, PMID:9651178]
+subset: human_reference_atlas
is_a: CL:0000152 ! exocrine cell
is_a: CL:0019001 ! tracheobronchial serous cell
intersection_of: CL:0000313 ! serous secreting cell
intersection_of: part_of UBERON:8410043 ! bronchus submucosal gland
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:8410043 ! bronchus submucosal gland
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
[Term]
id: CL:4033006
@@ -35388,13 +35153,15 @@ id: CL:4033014
name: peg cell
def: "A small, narrow, peg-shaped epithelial cell with little cytoplasm that is part of oviduct epithelium. This cell is rarer than the ciliated and secretory epithelial cells of the fallopian tube epithelium and is often found intercalated between them. Peg cells are generally distributed basally along the epithelium and have been found in high concentrations at the fimbriated, distal end of the fallopian tube in humans. It may have a regenerative/stem-cell function. In humans, markers include EPCAM, CD44, and ITGA6." [PMID:2210508, PMID:22911892, PMID:30023181]
comment: In vitro evidence supports a stem-cell/regenerative function for these cells {xref="PMID:22911892"}
+subset: human_reference_atlas
synonym: "fallopian tube epithelial stem-like cell" EXACT [PMID:22911892]
synonym: "FTE stem-like cell" EXACT [PMID:22911892]
-synonym: "FTESC" EXACT abbreviation [PMID:22911892]
+synonym: "FTESC" EXACT OMO:0003000 [PMID:22911892]
synonym: "intercalary cell" EXACT [PMID:22911892]
is_a: CL:0000066 ! epithelial cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: part_of UBERON:0004804 ! oviduct epithelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-02-02T15:07:12Z" xsd:dateTime
[Term]
@@ -35418,8 +35185,8 @@ name: secondary crest myofibroblast
def: "A myofibroblast that is part of an alveoli during alveolarization. The contractile force of this cell elongates the secondary crest, while producing a framework of elastin and tenascin. During the maturation of the septa, secondary crest myofibroblasts, together with matrix fibroblasts, secrete metalloproteinases and other ECM‐remodeling proteins to thin the septal tip ECM. The secondary crest myofibroblast continues producing elastin, eventually undergoing apoptosis during adulthood." [PMID:31331942, PMID:33624948]
subset: human_reference_atlas
synonym: "alveolar myofibroblast" RELATED [PMID:31331942]
-synonym: "SCMF" RELATED abbreviation [PMID:33624948]
-synonym: "SCMFs" RELATED abbreviation [PMID:25448080]
+synonym: "SCMF" RELATED OMO:0003000 [PMID:33624948]
+synonym: "SCMFs" RELATED OMO:0003004 [PMID:25448080]
synonym: "secondary-crest myofibroblast" EXACT [PMID:31331942]
is_a: CL:0000186 ! myofibroblast cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
@@ -35448,10 +35215,10 @@ id: CL:4033018
name: lung megakaryocyte
def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116]
subset: human_reference_atlas
-synonym: "lung MKs" RELATED abbreviation [PMID:33351116]
+synonym: "lung MKs" RELATED OMO:0003004 [PMID:33351116]
synonym: "lung resident megakaryocyte" EXACT [PMID:36524131]
synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131]
-synonym: "MKL" RELATED abbreviation [PMID:36524131]
+synonym: "MKL" RELATED OMO:0003000 [PMID:36524131]
is_a: CL:0000556 ! megakaryocyte
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0000556 ! megakaryocyte
@@ -35468,7 +35235,7 @@ name: ON-blue cone bipolar cell
def: "An ON bipolar cell type with dendrites selectively contacting S-cones." [PMID:32032773]
comment: The axons of a blue cone bipolar cell terminate close to the ganglion cell layer, where they transfer the S-cone ON signal to small bistratified ganglion cells. Other targets of a blue cone bipolar cell include amacrine cells and possibly large bistratified ganglion cells. {xref="PMID:32032773"}
subset: human_reference_atlas
-synonym: "BB cell" RELATED abbreviation [PMID:32032773]
+synonym: "BB cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000749 ! ON-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35563,13 +35330,15 @@ property_value: dcterms-date "2023-03-16T16:12:50Z" xsd:dateTime
id: CL:4033026
name: lung perichondrial fibroblast
def: "A perichondrial fibroblast that is part of the lung." [PMID:36543915]
-synonym: "PC-fibro" RELATED abbreviation [PMID:36543915]
+subset: human_reference_atlas
+synonym: "PC-fibro" RELATED OMO:0003000 [PMID:36543915]
is_a: CL:0002553 ! fibroblast of lung
is_a: CL:4033025 ! perichondrial fibroblast
intersection_of: CL:4033025 ! perichondrial fibroblast
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T16:15:39Z" xsd:dateTime
[Term]
@@ -35578,9 +35347,9 @@ name: diffuse bipolar 1 cell
def: "An OFF diffuse bipolar cell that makes synaptic contact with both L/M and S-cone photoreceptors and only minimal contact with rod photoreceptors." [PMID:22006647]
comment: In primates, a diffuse bipolar 1 cell on average makes 81 ribbon (output) synapses, 13 contacts are with OFF parasol cells and 47 contacts are with OFF midget cells. This cell might make flat contacts at both triad-associated and non-triad-associated positions on the cone pedicle. {xref="PMID:22006647", xref="PMID:32032773"}
subset: human_reference_atlas
-synonym: "DB1 bipolar" RELATED abbreviation [PMID:22006647]
-synonym: "DB1 bipolar cell" RELATED abbreviation [PMID:22006647]
-synonym: "DB1 cell" RELATED abbreviation [PMID:32032773]
+synonym: "DB1 bipolar" RELATED OMO:0003000 [PMID:22006647]
+synonym: "DB1 bipolar cell" RELATED OMO:0003000 [PMID:22006647]
+synonym: "DB1 cell" RELATED OMO:0003000 [PMID:32032773]
synonym: "Diffuse Bipolar Cell Type DB1" EXACT [PMID:22006647]
is_a: CL:0000750 ! OFF-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
@@ -35593,7 +35362,7 @@ name: diffuse bipolar 2 cell
def: "An OFF diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells. This cell contains a large number of synaptic ribbons and a small axon arbor area." [PMID:25309346, PMID:26500507, PMID:27833534]
comment: In primates, a diffuse bipolar 2 cell makes an average of 133 ribbon synapses, 47 contacts are with OFF parasol cells and 4 contacts are with OFF midget cells. {xref="PMID:32032773"}
subset: human_reference_atlas
-synonym: "DB2 cell" RELATED abbreviation [PMID:32032773]
+synonym: "DB2 cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000750 ! OFF-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35605,8 +35374,8 @@ name: diffuse bipolar 3a cell
def: "An OFF calbindin-positive bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3a contacts with cones are triad-associated." [PMID:32032773, PMID:32555229, PMID:33009001]
comment: Originally, DB3a cells were termed diffuse bipolar 3 (DB3) cells. When an additional bipolar type which stratifies slightly more vitread and is calbindin negative was detected, this cell was renamed diffuse bipolar 3a cell. The axons of neighboring DB3a cells make homologous gap junctions. The DB3a cells provide the majority of their output to OFF parasol cells. {xref="DOI:10.3389/fnana.2015.00122", xref="PMID:32032773"}
subset: human_reference_atlas
-synonym: "DB3 cell" RELATED abbreviation [DOI:10.3389/fnana.2015.00122]
-synonym: "DB3a cell" RELATED abbreviation [PMID:32032773]
+synonym: "DB3 cell" RELATED OMO:0003000 [DOI:10.3389/fnana.2015.00122]
+synonym: "DB3a cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000750 ! OFF-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35618,7 +35387,7 @@ name: diffuse bipolar 3b cell
def: "An OFF calbindin-negative bipolar cell that has a large dendritic field and stratifies narrowly close to the middle of the inner plexiform layer. Its axon terminal is characterized by regularly branching and varicose processes resembling beads on a string. Most of DB3b contacts with cones are non-triad-associated." [PMID:32032773, PMID:32555229]
comment: In humans, a DB3b cell is CD15 positive. A DB3b cell might make sparse contacts to rod photoreceptors. {xref="PMID:24107939", xref="PMID:33009001", xref="PMID:32032773"}
subset: human_reference_atlas
-synonym: "DB3b cell" RELATED abbreviation [PMID:32032773]
+synonym: "DB3b cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000750 ! OFF-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35629,7 +35398,7 @@ id: CL:4033031
name: diffuse bipolar 4 cell
def: "An ON diffuse bipolar cell that predominantly connects to ON parasol cells and lateral amacrine cells." [PMID:27833534, PMID:32032773, PMID:32555229]
subset: human_reference_atlas
-synonym: "DB4 cell" RELATED abbreviation [PMID:32032773]
+synonym: "DB4 cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000749 ! ON-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35640,7 +35409,7 @@ id: CL:4033032
name: diffuse bipolar 6 cell
def: "An ON diffuse bipolar cell that has a large dendritic field and large axon terminals, which show little or no overlap. This cell predominantly connects to narrow thorny ganglion cells." [PMID:32032773, PMID:32555229]
subset: human_reference_atlas
-synonym: "DB6 cell" RELATED abbreviation [PMID:32032773]
+synonym: "DB6 cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000749 ! ON-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35651,7 +35420,7 @@ id: CL:4033033
name: flat midget bipolar cell
def: "An OFF bipolar cell with a small dendritic tree that provides most of the triad-associated basal (flat) contacts at cone pedicles." [PMID:32032773, PMID:32555229]
subset: human_reference_atlas
-synonym: "FMB cell" RELATED abbreviation [PMID:32032773]
+synonym: "FMB cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000750 ! OFF-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35662,7 +35431,7 @@ id: CL:4033034
name: invaginating midget bipolar cell
def: "An ON bipolar cell with a small dendritic tree that forms most of the central (invaginating) elements opposite the synaptic ribbon at the cone triad." [PMID:32032773, PMID:32555229]
subset: human_reference_atlas
-synonym: "IMB cell" RELATED abbreviation [PMID:32032773]
+synonym: "IMB cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000749 ! ON-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -35673,7 +35442,7 @@ id: CL:4033035
name: giant bipolar cell
def: "An ON bipolar cell that has large dendritic and axonal fields." [PMID:32032773, PMID:32555229]
comment: A giant bipolar cell is usually monostratified, although, very rarely, it can be bistratified. {xref="PMID:32032773"}
-synonym: "GB cell" RELATED abbreviation [PMID:32032773]
+synonym: "GB cell" RELATED OMO:0003000 [PMID:32032773]
is_a: CL:0000749 ! ON-bipolar cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
property_value: dcterms-date "2023-04-04T09:54:15Z" xsd:dateTime
@@ -35706,12 +35475,14 @@ property_value: dcterms-date "2023-04-20T10:55:50Z" xsd:dateTime
id: CL:4033038
name: lung resident memory CD4-positive, alpha-beta T cell
def: "An alpha-beta CD4 T cell that resides in the lung." [PMID:24064670, PMID:31265968]
-synonym: "lung CD4-positive TRM" RELATED abbreviation [PMID:31265968]
+subset: human_reference_atlas
+synonym: "lung CD4-positive TRM" RELATED OMO:0003000 [PMID:31265968]
synonym: "lung resident memory CD4 T cell" EXACT [PMID:24064670]
is_a: CL:0000897 ! CD4-positive, alpha-beta memory T cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0002048 ! lung
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-04-27T10:15:45Z" xsd:dateTime
[Term]
@@ -35719,11 +35490,13 @@ id: CL:4033039
name: lung resident memory CD8-positive, alpha-beta T cell
def: "An alpha-beta CD8 T cell that resides in the lung." [PMID:28418771, PMID:31265968]
comment: In the lung, CXCR6 regulates the localization of lung resident memory CD8-positive, alpha-beta T cells. {xref="PMID:31558615"}
-synonym: "lung CD8-positive TRM" RELATED abbreviation [PMID:31265968]
+subset: human_reference_atlas
+synonym: "lung CD8-positive TRM" RELATED OMO:0003000 [PMID:31265968]
is_a: CL:0000909 ! CD8-positive, alpha-beta memory T cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0002048 ! lung
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-04-27T10:16:07Z" xsd:dateTime
[Term]
@@ -35745,10 +35518,12 @@ property_value: dcterms-date "2023-05-24T12:23:35Z" xsd:dateTime
id: CL:4033041
name: CCL3-positive alveolar macrophage
def: "An alveolar macrophage that expresses CCL3." [PMID:37291214]
+subset: human_reference_atlas
synonym: "alveolar macrophage CCL3-positive" EXACT [PMID:37291214]
is_a: CL:0000583 ! alveolar macrophage
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002292 PR:000002123 ! expresses C-C motif chemokine 3
property_value: dcterms-date "2023-06-15T12:53:08Z" xsd:dateTime
@@ -35756,24 +35531,28 @@ property_value: dcterms-date "2023-06-15T12:53:08Z" xsd:dateTime
id: CL:4033042
name: metallothionein-positive alveolar macrophage
def: "An alveolar macrophage that expresses metallothionein." [PMID:37291214]
+subset: human_reference_atlas
synonym: "alveolar macrophage metallothionein-positive" EXACT [PMID:37291214]
synonym: "alveolar macrophage MT-positive" EXACT [PMID:37291214]
is_a: CL:0000583 ! alveolar macrophage
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-06-15T12:55:34Z" xsd:dateTime
[Term]
id: CL:4033043
name: lung interstitial macrophage
def: "A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation." [PMID:33382972, PMID:35017701, PMID:36211428]
-synonym: "lung IM" RELATED abbreviation [PMID:36211428]
+subset: human_reference_atlas
+synonym: "lung IM" RELATED OMO:0003000 [PMID:36211428]
is_a: CL:0000864 ! tissue-resident macrophage
is_a: CL:0002320 ! connective tissue cell
is_a: CL:1001603 ! lung macrophage
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0000114 ! lung connective tissue
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-06-15T12:58:11Z" xsd:dateTime
[Term]
@@ -35781,21 +35560,25 @@ id: CL:4033044
name: deuterosomal cell
def: "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis." [PMID:31558434, PMID:331922198, PMID:36883528, PMID:37291214]
comment: In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification. {xref="PMID:31558434", xref="PMID:36883528", xref="PMID:331922198"}
+subset: human_reference_atlas
is_a: CL:0002368 ! respiratory epithelial cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-06-20T10:27:17Z" xsd:dateTime
[Term]
id: CL:4033045
name: lung migratory dendritic cell
def: "A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells." [PMID:34516781]
-synonym: "lung mDC" RELATED abbreviation [PMID:34516781]
-synonym: "lung mDCs" RELATED abbreviation [PMID:34516781]
+subset: human_reference_atlas
+synonym: "lung mDC" RELATED OMO:0003000 [PMID:34516781]
+synonym: "lung mDCs" RELATED OMO:0003004 [PMID:34516781]
is_a: CL:0000451 ! dendritic cell
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-06-21T10:04:46Z" xsd:dateTime
[Term]
@@ -35831,6 +35614,7 @@ id: CL:4033048
name: respiratory suprabasal cell
def: "A respiratory epithelial cell with topographic nuclear position in between the basal and luminal cell of the airway epithelium. This non-basal, intermediate cell has limited proliferative capacity, ultrastructural features of basal cells and no defined features of the typically differentiated cellular phenotypes." [PMID:25564622]
comment: In humans, respiratory suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3. {xref="PMID:25658372", xref="doi:10.1101/2023.04.20.537495"}
+subset: human_reference_atlas
synonym: "respiratory parabasal cell" EXACT [PMID:25564622]
synonym: "respiratory suprabasal progenitor cell" EXACT [PMID:25658372]
is_a: CL:0002368 ! respiratory epithelial cell
@@ -35839,6 +35623,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: develops_from CL:0002633 ! respiratory basal cell
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-06-20T10:44:30Z" xsd:dateTime
[Term]
@@ -35901,8 +35686,8 @@ id: CL:4033053
name: small bistratified retinal ganglion cell
def: "A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree." [PMID:32032773]
synonym: "Polyak's shrub cell" RELATED [PMID:32032773]
-synonym: "sbRGC" RELATED abbreviation [PMID:34093409]
-synonym: "SBS ganglion cell" RELATED abbreviation [PMID:32032773]
+synonym: "sbRGC" RELATED OMO:0003000 [PMID:34093409]
+synonym: "SBS ganglion cell" RELATED OMO:0003000 [PMID:32032773]
synonym: "small bistratified cell" EXACT [PMID:32032773]
synonym: "small bistratified cell, blue-ON/yellow-OFF ganglion cell" EXACT [doi:10.1002/cne.22183]
is_a: CL:0003001 ! bistratified retinal ganglion cell
@@ -35925,6 +35710,7 @@ property_value: dcterms-date "2023-08-22T13:40:28Z" xsd:dateTime
id: CL:4033055
name: airway submucosal gland duct ciliated cell
def: "A ciliated cell that is part of a ciliated duct of an airway submucosal gland." [PMID:17707699, PMID:30864819]
+subset: human_reference_atlas
is_a: CL:0000064 ! ciliated cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: part_of UBERON:8410077 ! airway submucosal gland
@@ -35933,14 +35719,93 @@ relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
relationship: part_of UBERON:8410077 ! airway submucosal gland
relationship: part_of UBERON:8600014 ! submucosal gland ciliated duct
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-09-08T10:32:27Z" xsd:dateTime
+[Term]
+id: CL:4033056
+name: onychocyte
+def: "A differentiated flat keratinocyte that is part of a nail plate. An onychocyte is firmly adherent and does not desquamate." [PMID:24079581]
+is_a: CL:0000312 ! keratinocyte
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
+relationship: part_of UBERON:0008198 ! nail plate
+property_value: dcterms-date "2023-10-03T12:49:46Z" xsd:dateTime
+
+[Term]
+id: CL:4033057
+name: luminal adaptive secretory precursor cell of mammary gland
+def: "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8." [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328, https://orcid.org/0000-0001-6677-8489, PMID:19648928, PMID:35617956]
+synonym: "alveolar cell" BROAD [PMID:35617956]
+synonym: "alveolar progenitor" BROAD [PMID:26390871]
+synonym: "AP" RELATED OMO:0003000 [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328]
+synonym: "AV" RELATED OMO:0003000 [PMID:35617956]
+synonym: "ER-negative luminal alveolar progenitor" EXACT [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328]
+synonym: "LASP" RELATED OMO:0003000 [https://orcid.org/0000-0001-6677-8489]
+synonym: "LP" RELATED OMO:0003000 [doi:10.1101/2023.04.21.537845]
+synonym: "luminal progenitor" BROAD [doi:10.1101/2023.04.21.537845]
+synonym: "luminal progenitor cell" BROAD [PMID:20346151]
+synonym: "luminal secretory cell" BROAD [PMID:37380767]
+synonym: "LumSec" RELATED OMO:0003000 [PMID:37380767]
+is_a: CL:0002326 ! luminal epithelial cell of mammary gland
+is_a: CL:0011026 ! progenitor cell
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
+relationship: dc-contributor https://orcid.org/0000-0003-4969-670X
+property_value: dcterms-date "2023-10-13T13:02:55Z" xsd:dateTime
+
+[Term]
+id: CL:4033058
+name: luminal hormone-sensing cell of mammary gland
+def: "A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a)." [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328, https://orcid.org/0000-0001-6677-8489, PMID:19648928, PMID:26390871, PMID:34156490]
+comment: Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad. {xref="PMID:34156490", xref="PMID:26390871", xref="https://orcid.org/0000-0003-4969-670X"}
+synonym: "ER-positive luminal hormone-sensor cell" EXACT [https://nrs.harvard.edu/URN-3\:HUL.INSTREPOS\:37368328]
+synonym: "hormone sensing cell" BROAD [doi:10.1101/2023.04.21.537845]
+synonym: "hormone-sensing mammary epithelial cell" BROAD [PMID:26390871]
+synonym: "HS" RELATED OMO:0003000 [doi:10.1101/2023.04.21.537845]
+synonym: "HS-MEC" RELATED OMO:0003000 [PMID:26390871]
+synonym: "LHS" RELATED OMO:0003000 [https://orcid.org/0000-0001-6677-8489]
+synonym: "LumHR" RELATED OMO:0003000 [PMID:37380767]
+synonym: "luminal hormone-responsive cell" BROAD [PMID:37380767]
+synonym: "luminal mature cell" BROAD [PMID:20346151]
+is_a: CL:0000152 ! exocrine cell
+is_a: CL:0000512 ! paracrine cell
+is_a: CL:0002326 ! luminal epithelial cell of mammary gland
+is_a: PR:000050567 ! protein-containing material entity
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
+relationship: dc-contributor https://orcid.org/0000-0003-4969-670X
+relationship: RO:0002104 PR:000007204 ! has plasma membrane part estrogen receptor
+property_value: dcterms-date "2023-10-16T08:30:25Z" xsd:dateTime
+
+[Term]
+id: CL:4033059
+name: lactocyte type 1
+def: "A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2." [PMID:35091553, PMID:35377806]
+synonym: "LC1" RELATED OMO:0003000 [PMID:35091553]
+synonym: "LMC major luminal cluster 1" RELATED [PMID:35091553]
+synonym: "luminal cluster 1 cell" BROAD [PMID:34097179]
+synonym: "progenitor MEC" RELATED OMO:0003000 [PMID:35091553]
+is_a: CL:0002325 ! lactocyte
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
+relationship: dc-contributor https://orcid.org/0000-0003-4361-817X
+property_value: dcterms-date "2023-10-16T13:15:36Z" xsd:dateTime
+
+[Term]
+id: CL:4033060
+name: lactocyte type 2
+def: "A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis." [PMID:35091553, PMID:35377806]
+synonym: "LC2" RELATED OMO:0003000 [PMID:35091553]
+synonym: "LMC major luminal cluster 2" RELATED [PMID:35091553]
+synonym: "luminal cluster 2 cell" BROAD [PMID:35377806]
+is_a: CL:0002325 ! lactocyte
+relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
+relationship: dc-contributor https://orcid.org/0000-0003-4361-817X
+property_value: dcterms-date "2023-10-16T13:15:55Z" xsd:dateTime
+
[Term]
id: CL:4040000
name: glial restricted tripotential precursor cell
def: "A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes." [PMID:10719353]
synonym: "glial restricted precursor" BROAD [PMID:10719353]
-synonym: "GRP cell" RELATED abbreviation [PMID:11756508]
+synonym: "GRP cell" RELATED OMO:0003000 [PMID:11756508]
synonym: "tripotential glial-restricted precursor cell" EXACT [PMID:11921204]
is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
@@ -36422,17 +36287,8 @@ synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
-[Term]
-id: GO:0001505
-name: regulation of neurotransmitter levels
-namespace: biological_process
-def: "Any process that modulates levels of neurotransmitter." [GOC:jl]
-relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
-relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-
[Term]
id: GO:0001508
name: action potential
@@ -36888,7 +36744,6 @@ synonym: "histamine breakdown" EXACT []
synonym: "histamine catabolism" EXACT []
synonym: "histamine degradation" EXACT []
is_a: GO:0001692 ! histamine metabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:58432
@@ -38339,6 +38194,7 @@ id: GO:0001974
name: blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing blood vessels." [GOC:hjd]
+synonym: "blood vessel remodelling" EXACT []
is_a: GO:0048771 ! tissue remodeling
[Term]
@@ -39219,10 +39075,11 @@ name: basophil activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "basophil activation during immune response" RELATED [GOC:tb]
-is_a: GO:0002275 ! myeloid cell activation involved in immune response
+is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0045575 ! basophil activation
intersection_of: GO:0045575 ! basophil activation
intersection_of: part_of GO:0006955 ! immune response
+relationship: part_of GO:0002275 ! myeloid cell activation involved in immune response
[Term]
id: GO:0002277
@@ -39275,10 +39132,11 @@ namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "macrophage activation during immune response" RELATED [GOC:tb]
synonym: "macrophage polarization involved in immune response" EXACT []
-is_a: GO:0002275 ! myeloid cell activation involved in immune response
+is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0042116 ! macrophage activation
intersection_of: GO:0042116 ! macrophage activation
intersection_of: part_of GO:0006955 ! immune response
+relationship: part_of GO:0002275 ! myeloid cell activation involved in immune response
[Term]
id: GO:0002282
@@ -41082,11 +40940,11 @@ id: GO:0002561
name: basophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149]
-is_a: GO:0002276 ! basophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: occurs_in CL:0000767 ! basophil
relationship: occurs_in CL:0000767 ! basophil
+relationship: part_of GO:0002276 ! basophil activation involved in immune response
relationship: part_of GO:0002560 ! basophil mediated immunity
[Term]
@@ -46408,7 +46266,21 @@ xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a"
xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino"
xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4"
xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation"
+xref: Reactome:R-HSA-9732753 "JAK1-activated RAF1 phosphorylates MAPKs"
xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation"
+xref: Reactome:R-HSA-9833820 "PKR dimer autophosphorylates"
+xref: Reactome:R-HSA-9835885 "p-PKR dimer phosphorylates eIF2-alpha"
+xref: Reactome:R-HSA-9836159 "p-PKR dimer phosphorylates DHX9"
+xref: Reactome:R-HSA-9836184 "p-PKR dimer phosphorylates CDK1"
+xref: Reactome:R-HSA-9836322 "p-PKR dimer phosphorylates MKK6"
+xref: Reactome:R-HSA-9836362 "p-PKR dimer phosphorylates TP53 tetramer"
+xref: Reactome:R-HSA-9836383 "p-PKR dimer phosphorylates ILF3:ILF2"
+xref: Reactome:R-HSA-9836404 "p-PKR dimer phosphorylates MAPT"
+xref: Reactome:R-HSA-9836435 "p-PKR dimer phosphorylates SNCA"
+xref: Reactome:R-HSA-9836449 "p-PKR dimer phosphorylates HIV tat"
+xref: Reactome:R-HSA-9836515 "p-PKR dimer phosphorylates PTPN2"
+xref: Reactome:R-HSA-9836617 "p-PKR dimer phosphorylates SPHK1"
+xref: Reactome:R-HSA-9836664 "p-PKR dimer phosphorylates PPP2R5A"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -46601,7 +46473,7 @@ xref: Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV"
xref: Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1"
xref: Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta"
xref: Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407"
-xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814"
+xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y779 and Y821"
xref: Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG"
xref: Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan"
xref: Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG"
@@ -46696,8 +46568,8 @@ xref: Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1"
xref: Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes"
xref: Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18"
xref: Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1"
-xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC"
-xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC"
+xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC"
+xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC"
xref: Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4"
xref: Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR"
xref: Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin"
@@ -46789,9 +46661,10 @@ xref: Reactome:R-HSA-9712085 "ALK mutants phosphorylate STAT3"
xref: Reactome:R-HSA-9712086 "ALK fusions phosphorylate PLCG1"
xref: Reactome:R-HSA-9712087 "ALK fusions phosphorylate FRS"
xref: Reactome:R-HSA-9726848 "SRC phosphorylates RHOU"
+xref: Reactome:R-HSA-9732738 "JAK1-mediated phosphorylation of RAF1"
xref: Reactome:R-HSA-9733314 "CSF1R trans-autophosphorylates on tyrosine-561"
xref: Reactome:R-HSA-9733323 "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL"
-xref: Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 486"
+xref: Reactome:R-HSA-9762209 "BACH1 is phosphorylated at tyrosine 483"
xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR"
xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)"
xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR"
@@ -46991,6 +46864,20 @@ intersection_of: has_input CHEBI:58432
relationship: has_input CHEBI:58432
relationship: has_part GO:0051381 ! histamine binding
+[Term]
+id: GO:0004970
+name: ionotropic glutamate receptor activity
+namespace: molecular_function
+def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]
+comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'.
+is_a: GO:0008066 ! glutamate receptor activity
+is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
+intersection_of: GO:0022836 ! gated channel activity
+intersection_of: has_primary_input CHEBI:24867
+intersection_of: has_small_molecule_activator CHEBI:14321
+relationship: has_small_molecule_activator CHEBI:14321
+relationship: part_of GO:0035235 ! ionotropic glutamate receptor signaling pathway
+
[Term]
id: GO:0004977
name: melanocortin receptor activity
@@ -47187,8 +47074,6 @@ subset: goslim_pir
subset: goslim_plant
subset: prokaryote_subset
synonym: "carrier" RELATED []
-xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion"
-xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol"
is_a: GO:0003674 ! molecular_function
[Term]
@@ -47203,19 +47088,12 @@ intersection_of: GO:0015267 ! channel activity
intersection_of: has_primary_input CHEBI:24867
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI
-[Term]
-id: GO:0005217
-name: intracellular ligand-gated monoatomic ion channel activity
-namespace: molecular_function
-def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
-synonym: "intracellular ligand-gated ion channel activity" BROAD []
-is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity
-
[Term]
id: GO:0005227
-name: calcium activated cation channel activity
+name: calcium-activated cation channel activity
namespace: molecular_function
def: "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
+synonym: "calcium activated cation channel activity" EXACT []
synonym: "intracellular calcium-activated potassium channel" NARROW []
synonym: "polycystin" NARROW []
xref: Reactome:R-HSA-9717383 "TRPM4 transports Na+ from the extracellular region to the cytosol"
@@ -47223,8 +47101,8 @@ is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0022836 ! gated channel activity
intersection_of: GO:0022836 ! gated channel activity
intersection_of: has_primary_input CHEBI:23906
-intersection_of: positively_regulated_by GO:0005509 ! calcium ion binding
-relationship: positively_regulated_by GO:0005509 ! calcium ion binding
+intersection_of: has_small_molecule_activator CHEBI:39124
+relationship: has_small_molecule_activator CHEBI:39124
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24605" xsd:anyURI
[Term]
@@ -49088,7 +48966,7 @@ synonym: "acetylcholine breakdown" EXACT []
synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
+is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:15355
relationship: has_primary_input CHEBI:15355
@@ -50840,7 +50718,6 @@ comment: A neurotransmitter is any of a group of substances that are released on
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
@@ -51774,7 +51651,7 @@ namespace: biological_process
alt_id: GO:0007452
def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid]
synonym: "imaginal disc metamorphosis" EXACT []
-is_a: GO:0048563 ! post-embryonic animal organ morphogenesis
+is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000939 ! imaginal disc
relationship: part_of GO:0007444 ! imaginal disc development
@@ -52470,7 +52347,7 @@ name: acetylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
-is_a: GO:0042133 ! neurotransmitter metabolic process
+is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:15355
relationship: has_primary_input_or_output CHEBI:15355
@@ -52485,7 +52362,7 @@ synonym: "acetylcholine biosynthesis" EXACT []
synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:15355
relationship: has_primary_output CHEBI:15355
@@ -52551,6 +52428,17 @@ relationship: has_primary_input CHEBI:23906
relationship: part_of GO:0098655 ! monoatomic cation transmembrane transport
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI
+[Term]
+id: GO:0008328
+name: ionotropic glutamate receptor complex
+namespace: cellular_component
+def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
+is_a: GO:0034702 ! monoatomic ion channel complex
+is_a: GO:0098878 ! neurotransmitter receptor complex
+intersection_of: GO:0032991 ! protein-containing complex
+intersection_of: capable_of GO:0004970 ! ionotropic glutamate receptor activity
+relationship: capable_of GO:0004970 ! ionotropic glutamate receptor activity
+
[Term]
id: GO:0008347
name: glial cell migration
@@ -57367,25 +57255,11 @@ xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors"
xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors"
xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors"
xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors"
+is_a: GO:0005216 ! monoatomic ion channel activity
is_a: GO:0022834 ! ligand-gated channel activity
-is_a: GO:0022839 ! monoatomic ion gated channel activity
-intersection_of: GO:0022834 ! ligand-gated channel activity
+intersection_of: GO:0022836 ! gated channel activity
intersection_of: has_primary_input CHEBI:24867
-
-[Term]
-id: GO:0015278
-name: calcium-release channel activity
-namespace: molecular_function
-alt_id: GO:0005218
-def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]
-synonym: "intracellular ligand-gated calcium channel activity" RELATED [GO:0015278]
-xref: Reactome:R-HSA-9717215 "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol"
-is_a: GO:0005217 ! intracellular ligand-gated monoatomic ion channel activity
-is_a: GO:0099604 ! ligand-gated calcium channel activity
-intersection_of: GO:0022834 ! ligand-gated channel activity
-intersection_of: has_primary_input CHEBI:29108
-intersection_of: part_of GO:0051209 ! release of sequestered calcium ion into cytosol
-relationship: part_of GO:0051209 ! release of sequestered calcium ion into cytosol
+intersection_of: has_small_molecule_activator CHEBI:24431
[Term]
id: GO:0015318
@@ -58343,6 +58217,19 @@ intersection_of: GO:0038023 ! signaling receptor activity
intersection_of: has_input CHEBI:59888
relationship: has_input CHEBI:59888
+[Term]
+id: GO:0016922
+name: nuclear receptor binding
+namespace: molecular_function
+alt_id: GO:0035257
+alt_id: GO:0035258
+def: "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]
+synonym: "ligand-dependent nuclear receptor binding" EXACT []
+synonym: "ligand-dependent nuclear receptor interactor activity" RELATED []
+synonym: "nuclear hormone receptor binding" EXACT []
+synonym: "steroid hormone receptor binding" BROAD []
+is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding
+
[Term]
id: GO:0017046
name: peptide hormone binding
@@ -58530,7 +58417,7 @@ id: GO:0019215
name: intermediate filament binding
namespace: molecular_function
def: "Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732]
-is_a: GO:0044877 ! protein-containing complex binding
+is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: has_input GO:0005882 ! intermediate filament
relationship: has_input GO:0005882 ! intermediate filament
@@ -58930,6 +58817,16 @@ intersection_of: GO:0098727 ! maintenance of cell number
intersection_of: acts_on_population_of CL:0000034 ! stem cell
relationship: acts_on_population_of CL:0000034 ! stem cell
+[Term]
+id: GO:0019865
+name: immunoglobulin binding
+namespace: molecular_function
+def: "Binding to an immunoglobulin." [GOC:ma]
+is_a: GO:0044877 ! protein-containing complex binding
+intersection_of: GO:0005488 ! binding
+intersection_of: has_input GO:0019814 ! immunoglobulin complex
+relationship: has_input GO:0019814 ! immunoglobulin complex
+
[Term]
id: GO:0019867
name: outer membrane
@@ -59007,7 +58904,7 @@ id: GO:0021510
name: spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
-is_a: GO:0048513 ! animal organ development
+is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002240 ! spinal cord
relationship: part_of GO:0007417 ! central nervous system development
@@ -61718,6 +61615,9 @@ name: ligand-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity
+intersection_of: GO:0022836 ! gated channel activity
+intersection_of: has_small_molecule_activator CHEBI:24431
+relationship: has_small_molecule_activator CHEBI:24431
[Term]
id: GO:0022835
@@ -61728,9 +61628,6 @@ synonym: "extracellular substance gated channel activity" EXACT []
synonym: "neurotransmitter-gated channel activity" EXACT []
is_a: GO:0022834 ! ligand-gated channel activity
is_a: GO:0030594 ! neurotransmitter receptor activity
-intersection_of: GO:0015267 ! channel activity
-intersection_of: regulated_by GO:0042165 ! neurotransmitter binding
-relationship: regulated_by GO:0042165 ! neurotransmitter binding
[Term]
id: GO:0022836
@@ -61741,14 +61638,15 @@ is_a: GO:0015267 ! channel activity
[Term]
id: GO:0022839
-name: monoatomic ion gated channel activity
+name: monoatomic ion-gated channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport]
synonym: "ion gated channel activity" BROAD []
-is_a: GO:0005216 ! monoatomic ion channel activity
+synonym: "monoatomic ion gated channel activity" EXACT []
is_a: GO:0022836 ! gated channel activity
intersection_of: GO:0022836 ! gated channel activity
-intersection_of: has_primary_input CHEBI:24867
+intersection_of: has_small_molecule_activator CHEBI:24867
+relationship: has_small_molecule_activator CHEBI:24867
[Term]
id: GO:0022848
@@ -61769,12 +61667,23 @@ is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity
is_a: GO:1904315 ! transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
intersection_of: GO:0022834 ! ligand-gated channel activity
intersection_of: has_primary_input CHEBI:23906
-intersection_of: regulated_by GO:0042166 ! acetylcholine binding
-relationship: regulated_by GO:0042166 ! acetylcholine binding
+intersection_of: has_small_molecule_activator CHEBI:15355
+relationship: has_small_molecule_activator CHEBI:15355
+
+[Term]
+id: GO:0022849
+name: glutamate-gated calcium ion channel activity
+namespace: molecular_function
+def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
+is_a: GO:0004970 ! ionotropic glutamate receptor activity
+is_a: GO:0099604 ! ligand-gated calcium channel activity
+intersection_of: GO:0022836 ! gated channel activity
+intersection_of: has_primary_input CHEBI:29108
+intersection_of: has_small_molecule_activator CHEBI:14321
[Term]
id: GO:0022850
-name: serotonin-gated monoatomic cation-selective channel activity
+name: serotonin-gated monoatomic cation channel activity
namespace: molecular_function
alt_id: GO:0005232
def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
@@ -61783,16 +61692,17 @@ synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW []
synonym: "serotonin-activated cation-selective channel activity" EXACT []
synonym: "serotonin-gated cation channel activity" NARROW []
synonym: "serotonin-gated cation-selective channel activity" BROAD []
+synonym: "serotonin-gated monoatomic cation-selective channel activity" EXACT []
xref: Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+"
xref: Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+"
is_a: GO:0022824 ! transmitter-gated monoatomic ion channel activity
is_a: GO:0099094 ! ligand-gated monoatomic cation channel activity
is_a: GO:0099589 ! serotonin receptor activity
-intersection_of: GO:0022834 ! ligand-gated channel activity
+intersection_of: GO:0022836 ! gated channel activity
intersection_of: has_primary_input CHEBI:23906
-intersection_of: regulated_by GO:0051378 ! serotonin binding
+intersection_of: has_small_molecule_activator CHEBI:350546
+relationship: has_small_molecule_activator CHEBI:350546
relationship: part_of GO:0007210 ! serotonin receptor signaling pathway
-relationship: regulated_by GO:0051378 ! serotonin binding
[Term]
id: GO:0022857
@@ -61813,6 +61723,7 @@ synonym: "uptake permease activity" RELATED []
synonym: "uptake transmembrane transporter activity" RELATED []
xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61"
xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate"
+xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics"
xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate"
xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA"
xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome"
@@ -63062,6 +62973,18 @@ intersection_of: results_in_development_of UBERON:0002369 ! adrenal gland
relationship: part_of GO:0035270 ! endocrine system development
relationship: results_in_development_of UBERON:0002369 ! adrenal gland
+[Term]
+id: GO:0030331
+name: nuclear estrogen receptor binding
+namespace: molecular_function
+def: "Binding to a nuclear estrogen receptor." [GOC:ai]
+synonym: "estrogen receptor binding" BROAD []
+is_a: GO:0016922 ! nuclear receptor binding
+intersection_of: GO:0005488 ! binding
+intersection_of: has_input PR:000007204 ! estrogen receptor
+relationship: has_input PR:000007204 ! estrogen receptor
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/16717" xsd:anyURI
+
[Term]
id: GO:0030334
name: regulation of cell migration
@@ -63318,7 +63241,6 @@ synonym: "bile acid breakdown" EXACT []
synonym: "bile acid catabolism" EXACT []
synonym: "bile acid degradation" EXACT []
synonym: "cholate catabolic process" NARROW []
-xref: MetaCyc:7ALPHADEHYDROX-PWY
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0009056 ! catabolic process
intersection_of: GO:0009056 ! catabolic process
@@ -63356,7 +63278,6 @@ namespace: molecular_function
def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity'
is_a: GO:0038023 ! signaling receptor activity
-relationship: has_part GO:0042165 ! neurotransmitter binding
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
@@ -70282,6 +70203,7 @@ id: GO:0034103
name: regulation of tissue remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add]
+synonym: "regulation of tissue remodelling" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048771 ! tissue remodeling
@@ -70292,6 +70214,7 @@ id: GO:0034104
name: negative regulation of tissue remodeling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add]
+synonym: "negative regulation of tissue remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
@@ -70303,6 +70226,7 @@ id: GO:0034105
name: positive regulation of tissue remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add]
+synonym: "positive regulation of tissue remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
@@ -71412,7 +71336,6 @@ namespace: biological_process
def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf]
synonym: "post-embryonic haemopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
-is_a: GO:0048569 ! post-embryonic animal organ development
relationship: part_of GO:0009791 ! post-embryonic development
[Term]
@@ -71604,6 +71527,18 @@ intersection_of: GO:0012501 ! programmed cell death
intersection_of: occurs_in CL:0000586 ! germ cell
relationship: occurs_in CL:0000586 ! germ cell
+[Term]
+id: GO:0035235
+name: ionotropic glutamate receptor signaling pathway
+namespace: biological_process
+def: "The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732]
+synonym: "ionotropic glutamate receptor signalling pathway" EXACT []
+is_a: GO:0007215 ! glutamate receptor signaling pathway
+is_a: GO:1990806 ! ligand-gated ion channel signaling pathway
+intersection_of: GO:0007165 ! signal transduction
+intersection_of: starts_with GO:0004970 ! ionotropic glutamate receptor activity
+relationship: starts_with GO:0004970 ! ionotropic glutamate receptor activity
+
[Term]
id: GO:0035239
name: tube morphogenesis
@@ -72723,6 +72658,19 @@ relationship: part_of GO:0005929 ! cilium
created_by: bf
creation_date: 2011-05-25T03:09:58Z
+[Term]
+id: GO:0035878
+name: nail development
+namespace: biological_process
+def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)]
+is_a: GO:0048856 ! anatomical structure development
+intersection_of: GO:0048856 ! anatomical structure development
+intersection_of: results_in_development_of UBERON:0001705 ! nail
+relationship: part_of GO:0060173 ! limb development
+relationship: results_in_development_of UBERON:0001705 ! nail
+created_by: bf
+creation_date: 2011-05-31T02:30:34Z
+
[Term]
id: GO:0035881
name: amacrine cell differentiation
@@ -74431,43 +74379,6 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042098 ! T cell proliferation
relationship: negatively_regulates GO:0042098 ! T cell proliferation
-[Term]
-id: GO:0042133
-name: neurotransmitter metabolic process
-namespace: biological_process
-def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]
-subset: goslim_pir
-synonym: "neurotransmitter metabolism" EXACT []
-is_a: GO:0044237 ! cellular metabolic process
-relationship: never_in_taxon NCBITaxon:4895 ! Schizosaccharomyces
-
-[Term]
-id: GO:0042135
-name: neurotransmitter catabolic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]
-subset: goslim_synapse
-synonym: "neurotransmitter breakdown" EXACT []
-synonym: "neurotransmitter catabolism" EXACT []
-synonym: "neurotransmitter degradation" EXACT []
-is_a: GO:0042133 ! neurotransmitter metabolic process
-is_a: GO:0044248 ! cellular catabolic process
-
-[Term]
-id: GO:0042136
-name: neurotransmitter biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]
-subset: goslim_synapse
-synonym: "neurotransmitter anabolism" EXACT []
-synonym: "neurotransmitter biosynthesis" EXACT []
-synonym: "neurotransmitter biosynthesis and storage" BROAD []
-synonym: "neurotransmitter biosynthetic process and storage" BROAD []
-synonym: "neurotransmitter formation" EXACT []
-synonym: "neurotransmitter synthesis" EXACT []
-is_a: GO:0042133 ! neurotransmitter metabolic process
-is_a: GO:0044249 ! cellular biosynthetic process
-
[Term]
id: GO:0042151
name: nematocyst
@@ -74521,20 +74432,12 @@ intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:6495
relationship: has_primary_input CHEBI:6495
-[Term]
-id: GO:0042165
-name: neurotransmitter binding
-namespace: molecular_function
-def: "Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732]
-subset: goslim_pir
-is_a: GO:0005488 ! binding
-
[Term]
id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def: "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
-is_a: GO:0042165 ! neurotransmitter binding
+is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: has_input CHEBI:15355
relationship: has_input CHEBI:15355
@@ -75872,7 +75775,7 @@ synonym: "T-lymphocyte receptor binding" EXACT []
synonym: "TCR binding" EXACT []
is_a: GO:0005102 ! signaling receptor binding
is_a: GO:0044877 ! protein-containing complex binding
-intersection_of: GO:0044877 ! protein-containing complex binding
+intersection_of: GO:0005488 ! binding
intersection_of: has_input GO:0042101 ! T cell receptor complex
relationship: has_input GO:0042101 ! T cell receptor complex
@@ -76847,7 +76750,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -77073,14 +76976,15 @@ is_a: GO:0006909 ! phagocytosis
[Term]
id: GO:0043282
-name: pharyngeal muscle development
+name: chordate pharyngeal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000933 ! chordate pharyngeal muscle
-relationship: part_of GO:0060465 ! pharynx development
+relationship: part_of GO:0160093 ! chordate pharynx development
relationship: results_in_development_of UBERON:0000933 ! chordate pharyngeal muscle
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18285" xsd:anyURI
[Term]
id: GO:0043292
@@ -77189,13 +77093,13 @@ name: mast cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149]
synonym: "mast cell granule exocytosis" EXACT []
-is_a: GO:0002279 ! mast cell activation involved in immune response
is_a: GO:0032418 ! lysosome localization
is_a: GO:0043299 ! leukocyte degranulation
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: has_primary_input GO:0042629 ! mast cell granule
relationship: has_primary_input GO:0042629 ! mast cell granule
+relationship: part_of GO:0002279 ! mast cell activation involved in immune response
relationship: part_of GO:0002448 ! mast cell mediated immunity
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/15943" xsd:anyURI
@@ -77206,7 +77110,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149]
synonym: "regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
-is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0043300 ! regulation of leukocyte degranulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043303 ! mast cell degranulation
@@ -77223,7 +77126,6 @@ synonym: "downregulation of mast cell degranulation" EXACT []
synonym: "inhibition of mast cell degranulation" NARROW []
synonym: "negative regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
-is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
intersection_of: GO:0065007 ! biological regulation
@@ -77241,7 +77143,6 @@ synonym: "stimulation of mast cell degranulation" NARROW []
synonym: "up regulation of mast cell degranulation" EXACT []
synonym: "up-regulation of mast cell degranulation" EXACT []
synonym: "upregulation of mast cell degranulation" EXACT []
-is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
intersection_of: GO:0065007 ! biological regulation
@@ -77264,11 +77165,11 @@ name: eosinophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149]
synonym: "eosinophil granule exocytosis" EXACT []
-is_a: GO:0002278 ! eosinophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: occurs_in CL:0000771 ! eosinophil
relationship: occurs_in CL:0000771 ! eosinophil
+relationship: part_of GO:0002278 ! eosinophil activation involved in immune response
relationship: part_of GO:0002447 ! eosinophil mediated immunity
[Term]
@@ -77280,7 +77181,6 @@ synonym: "regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
-is_a: GO:1902566 ! regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043308 ! eosinophil degranulation
relationship: regulates GO:0043308 ! eosinophil degranulation
@@ -77299,7 +77199,6 @@ is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
is_a: GO:0050777 ! negative regulation of immune response
-is_a: GO:1902567 ! negative regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043308 ! eosinophil degranulation
relationship: negatively_regulates GO:0043308 ! eosinophil degranulation
@@ -77319,7 +77218,6 @@ is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
is_a: GO:0050778 ! positive regulation of immune response
-is_a: GO:1902568 ! positive regulation of eosinophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043308 ! eosinophil degranulation
relationship: positively_regulates GO:0043308 ! eosinophil degranulation
@@ -77331,11 +77229,11 @@ namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149]
synonym: "heterophil degranulation" RELATED []
synonym: "neutrophil granule exocytosis" EXACT []
-is_a: GO:0002283 ! neutrophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: occurs_in CL:0000775 ! neutrophil
relationship: occurs_in CL:0000775 ! neutrophil
+relationship: part_of GO:0002283 ! neutrophil activation involved in immune response
relationship: part_of GO:0002446 ! neutrophil mediated immunity
[Term]
@@ -77347,7 +77245,6 @@ synonym: "regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
-is_a: GO:1902563 ! regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043312 ! neutrophil degranulation
relationship: regulates GO:0043312 ! neutrophil degranulation
@@ -77366,7 +77263,6 @@ is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
is_a: GO:0050777 ! negative regulation of immune response
-is_a: GO:1902564 ! negative regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043312 ! neutrophil degranulation
relationship: negatively_regulates GO:0043312 ! neutrophil degranulation
@@ -77386,7 +77282,6 @@ is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
is_a: GO:0050778 ! positive regulation of immune response
-is_a: GO:1902565 ! positive regulation of neutrophil activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043312 ! neutrophil degranulation
relationship: positively_regulates GO:0043312 ! neutrophil degranulation
@@ -77403,12 +77298,12 @@ synonym: "cytotoxic T-cell degranulation" EXACT []
synonym: "cytotoxic T-cell granule exocytosis" EXACT []
synonym: "cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT []
-is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: occurs_in CL:0000910 ! cytotoxic T cell
relationship: occurs_in CL:0000910 ! cytotoxic T cell
relationship: part_of GO:0001913 ! T cell mediated cytotoxicity
+relationship: part_of GO:0002286 ! T cell activation involved in immune response
[Term]
id: GO:0043317
@@ -77424,7 +77319,6 @@ synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
-is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043316 ! cytotoxic T cell degranulation
relationship: regulates GO:0043316 ! cytotoxic T cell degranulation
@@ -77448,7 +77342,6 @@ synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXAC
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
-is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation
relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation
@@ -77473,7 +77366,6 @@ synonym: "upregulation of cytotoxic T cell degranulation" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
-is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043316 ! cytotoxic T cell degranulation
relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation
@@ -77486,11 +77378,11 @@ def: "The regulated exocytosis of secretory granules containing preformed mediat
synonym: "natural killer cell granule exocytosis" EXACT []
synonym: "NK cell degranulation" EXACT []
synonym: "NK cell granule exocytosis" EXACT []
-is_a: GO:0002323 ! natural killer cell activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
intersection_of: GO:0045055 ! regulated exocytosis
intersection_of: occurs_in CL:0000623 ! natural killer cell
relationship: occurs_in CL:0000623 ! natural killer cell
+relationship: part_of GO:0002323 ! natural killer cell activation involved in immune response
relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity
[Term]
@@ -77501,7 +77393,6 @@ def: "Any process that modulates the frequency, rate, or extent of natural kille
synonym: "regulation of natural killer cell granule exocytosis" EXACT []
synonym: "regulation of NK cell degranulation" EXACT []
synonym: "regulation of NK cell granule exocytosis" EXACT []
-is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
intersection_of: GO:0065007 ! biological regulation
@@ -77520,7 +77411,6 @@ synonym: "inhibition of natural killer cell degranulation" NARROW []
synonym: "negative regulation of natural killer cell granule exocytosis" EXACT []
synonym: "negative regulation of NK cell degranulation" EXACT []
synonym: "negative regulation of NK cell granule exocytosis" EXACT []
-is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
@@ -77541,7 +77431,6 @@ synonym: "stimulation of natural killer cell degranulation" NARROW []
synonym: "up regulation of natural killer cell degranulation" EXACT []
synonym: "up-regulation of natural killer cell degranulation" EXACT []
synonym: "upregulation of natural killer cell degranulation" EXACT []
-is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
@@ -78496,7 +78385,7 @@ id: GO:0043932
name: ossification involved in bone remodeling
namespace: biological_process
def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo]
-synonym: "ossification involved in bone remodelling" RELATED []
+synonym: "ossification involved in bone remodelling" EXACT []
is_a: GO:0001503 ! ossification
intersection_of: GO:0001503 ! ossification
intersection_of: part_of GO:0046849 ! bone remodeling
@@ -78939,19 +78828,6 @@ relationship: part_of CL:0000000 ! cell
created_by: jl
creation_date: 2010-02-05T10:37:16Z
-[Term]
-id: GO:0044302
-name: dentate gyrus mossy fiber
-namespace: cellular_component
-def: "Distinctive, unmyelinated axons produced by dentate gyrus granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709]
-synonym: "dentate gyrus mossy fibre" EXACT []
-synonym: "granule cell axon" BROAD []
-xref: NIF_Subcellular:nlx_subcell_20090601
-is_a: GO:0030424 ! axon
-relationship: part_of CL:2000089 ! dentate gyrus granule cell
-created_by: jl
-creation_date: 2010-02-05T11:23:55Z
-
[Term]
id: GO:0044306
name: neuron projection terminus
@@ -84747,6 +84623,7 @@ id: GO:0046850
name: regulation of bone remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai]
+synonym: "regulation of bone remodelling" EXACT []
is_a: GO:0034103 ! regulation of tissue remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046849 ! bone remodeling
@@ -84761,6 +84638,7 @@ synonym: "down regulation of bone remodeling" EXACT []
synonym: "down-regulation of bone remodeling" EXACT []
synonym: "downregulation of bone remodeling" EXACT []
synonym: "inhibition of bone remodeling" NARROW []
+synonym: "negative regulation of bone remodelling" EXACT []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
intersection_of: GO:0065007 ! biological regulation
@@ -84773,6 +84651,7 @@ name: positive regulation of bone remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "activation of bone remodeling" NARROW []
+synonym: "positive regulation of bone remodelling" EXACT []
synonym: "stimulation of bone remodeling" NARROW []
synonym: "up regulation of bone remodeling" EXACT []
synonym: "up-regulation of bone remodeling" EXACT []
@@ -85825,9 +85704,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048514
@@ -86095,15 +85972,6 @@ is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048568 ! embryonic organ development
-[Term]
-id: GO:0048563
-name: post-embryonic animal organ morphogenesis
-namespace: biological_process
-def: "Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
-is_a: GO:0009886 ! post-embryonic animal morphogenesis
-is_a: GO:0009887 ! animal organ morphogenesis
-relationship: part_of GO:0048569 ! post-embryonic animal organ development
-
[Term]
id: GO:0048565
name: digestive tract development
@@ -86129,14 +85997,7 @@ intersection_of: GO:0048856 ! anatomical structure development
intersection_of: part_of GO:0009790 ! embryo development
intersection_of: results_in_development_of UBERON:0000062 ! organ
relationship: part_of GO:0009790 ! embryo development
-
-[Term]
-id: GO:0048569
-name: post-embryonic animal organ development
-namespace: biological_process
-def: "Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
-synonym: "post-embryonic animal organogenesis" EXACT []
-is_a: GO:0048513 ! animal organ development
+relationship: results_in_development_of UBERON:0000062 ! organ
[Term]
id: GO:0048570
@@ -87050,6 +86911,7 @@ name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
+synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process
[Term]
@@ -89028,6 +88890,20 @@ intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050817 ! coagulation
relationship: positively_regulates GO:0050817 ! coagulation
+[Term]
+id: GO:0050825
+name: ice binding
+namespace: molecular_function
+def: "Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators]
+synonym: "antifreeze activity" RELATED []
+synonym: "ice crystal binding" EXACT []
+synonym: "ice nucleation activity" RELATED []
+synonym: "ice nucleation inhibitor activity" RELATED []
+is_a: GO:0036094 ! small molecule binding
+intersection_of: GO:0036094 ! small molecule binding
+intersection_of: has_input CHEBI:15377
+relationship: has_input CHEBI:15377
+
[Term]
id: GO:0050832
name: defense response to fungus
@@ -91094,12 +90970,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051235
@@ -95247,6 +95125,7 @@ id: GO:0060312
name: regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
+synonym: "regulation of blood vessel remodelling" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034103 ! regulation of tissue remodeling
intersection_of: GO:0065007 ! biological regulation
@@ -95260,6 +95139,7 @@ namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb]
+synonym: "negative regulation of blood vessel remodelling" EXACT []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060312 ! regulation of blood vessel remodeling
@@ -95563,7 +95443,6 @@ id: GO:0060408
name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
-is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
@@ -95575,7 +95454,6 @@ id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
-is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
@@ -95587,7 +95465,6 @@ id: GO:0060410
name: negative regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
-is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
@@ -102164,7 +102041,7 @@ id: GO:0062094
name: stomach development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278]
-is_a: GO:0048513 ! animal organ development
+is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000945 ! stomach
relationship: part_of GO:0048565 ! digestive tract development
@@ -110730,9 +110607,11 @@ creation_date: 2012-12-19T13:01:02Z
id: GO:0097457
name: hippocampal mossy fiber
namespace: cellular_component
-def: "Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709]
+def: "An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709, PMID:20554881, PMID:24336151]
xref: NIF_Subcellular:nlx_subcell_100312
-is_a: GO:0044302 ! dentate gyrus mossy fiber
+is_a: GO:0030424 ! axon
+relationship: part_of CL:0001033 ! hippocampal granule cell
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25796" xsd:anyURI
created_by: pr
creation_date: 2012-12-19T16:51:57Z
@@ -111280,7 +111159,7 @@ id: GO:0098633
name: collagen fibril binding
namespace: molecular_function
def: "Binding to a collagen fibril." [GOC:dos, PMID:21421911]
-is_a: GO:0044877 ! protein-containing complex binding
+is_a: GO:0005488 ! binding
intersection_of: GO:0005488 ! binding
intersection_of: has_input GO:0098643 ! banded collagen fibril
relationship: has_input GO:0098643 ! banded collagen fibril
@@ -112485,8 +112364,9 @@ def: "Enables the transmembrane transfer of an inorganic cation by a channel tha
synonym: "ligand-gated cation channel activity" BROAD []
is_a: GO:0005261 ! monoatomic cation channel activity
is_a: GO:0022834 ! ligand-gated channel activity
-intersection_of: GO:0022834 ! ligand-gated channel activity
+intersection_of: GO:0022836 ! gated channel activity
intersection_of: has_primary_input CHEBI:23906
+intersection_of: has_small_molecule_activator CHEBI:24431
[Term]
id: GO:0099096
@@ -113366,8 +113246,9 @@ namespace: molecular_function
def: "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos]
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0022834 ! ligand-gated channel activity
-intersection_of: GO:0022834 ! ligand-gated channel activity
+intersection_of: GO:0022836 ! gated channel activity
intersection_of: has_primary_input CHEBI:29108
+intersection_of: has_small_molecule_activator CHEBI:24431
relationship: part_of GO:0019722 ! calcium-mediated signaling
[Term]
@@ -113493,6 +113374,7 @@ id: GO:0101010
name: pulmonary blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing pulmonary blood vessels." [GOC:mec]
+synonym: "pulmonary blood vessel remodelling" EXACT []
is_a: GO:0001974 ! blood vessel remodeling
intersection_of: GO:0001974 ! blood vessel remodeling
intersection_of: occurs_in UBERON:0008886 ! pulmonary vascular system
@@ -113736,56 +113618,6 @@ relationship: positively_regulates GO:0110021 ! cardiac muscle myoblast prolifer
created_by: kmv
creation_date: 2017-06-29T15:24:16Z
-[Term]
-id: GO:0110040
-name: pharynx morphogenesis
-namespace: biological_process
-def: "The process in which the anatomical structures of the pharynx are generated and organized." [GOC:rz, PMID:20805556]
-is_a: GO:0009653 ! anatomical structure morphogenesis
-intersection_of: GO:0009653 ! anatomical structure morphogenesis
-intersection_of: results_in_morphogenesis_of UBERON:0006562 ! pharynx
-relationship: results_in_morphogenesis_of UBERON:0006562 ! pharynx
-created_by: kmv
-creation_date: 2017-07-24T20:51:28Z
-
-[Term]
-id: GO:0110041
-name: regulation of pharynx morphogenesis
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized." [GOC:rz, PMID:20805556]
-is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0110040 ! pharynx morphogenesis
-relationship: regulates GO:0110040 ! pharynx morphogenesis
-created_by: kmv
-creation_date: 2017-07-24T21:00:20Z
-
-[Term]
-id: GO:0110042
-name: negative regulation of pharynx morphogenesis
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pharynx morphogenesis." [GOC:rz, PMID:20805556]
-is_a: GO:0051093 ! negative regulation of developmental process
-is_a: GO:0110041 ! regulation of pharynx morphogenesis
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0110040 ! pharynx morphogenesis
-relationship: negatively_regulates GO:0110040 ! pharynx morphogenesis
-created_by: kmv
-creation_date: 2017-07-24T21:05:08Z
-
-[Term]
-id: GO:0110043
-name: positive regulation of pharynx morphogenesis
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of pharynx morphogenesis." [GOC:rz, PMID:20805556]
-is_a: GO:0051094 ! positive regulation of developmental process
-is_a: GO:0110041 ! regulation of pharynx morphogenesis
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0110040 ! pharynx morphogenesis
-relationship: positively_regulates GO:0110040 ! pharynx morphogenesis
-created_by: kmv
-creation_date: 2017-07-24T21:09:48Z
-
[Term]
id: GO:0110053
name: regulation of actin filament organization
@@ -114142,10 +113974,12 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
+is_a: CARO:0000000
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -114896,9 +114730,9 @@ synonym: "serotonin-gated cation-selective signalling pathway" EXACT []
is_a: GO:0007210 ! serotonin receptor signaling pathway
is_a: GO:1990806 ! ligand-gated ion channel signaling pathway
intersection_of: GO:0007165 ! signal transduction
-intersection_of: has_part GO:0022850 ! serotonin-gated monoatomic cation-selective channel activity
+intersection_of: has_part GO:0022850 ! serotonin-gated monoatomic cation channel activity
intersection_of: starts_with GO:0099589 ! serotonin receptor activity
-relationship: has_part GO:0022850 ! serotonin-gated monoatomic cation-selective channel activity
+relationship: has_part GO:0022850 ! serotonin-gated monoatomic cation channel activity
created_by: pg
creation_date: 2018-06-02T13:34:51Z
@@ -115222,6 +115056,7 @@ def: "Directly binding to a specific protein and delivering it to a specific cel
comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.
synonym: "protein carrier activity" RELATED []
synonym: "protein transport chaperone" RELATED []
+xref: Reactome:R-HSA-2248891 "M6PR transports activated ARSA to the lysosome"
xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network"
xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane"
is_a: GO:0005215 ! transporter activity
@@ -115869,6 +115704,34 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i
created_by: rynl
creation_date: 2022-08-19T23:18:54Z
+[Term]
+id: GO:0160083
+name: exhausted T cell differentiation
+namespace: biological_process
+def: "The process in which an activated T cell acquires specialized features of an exhausted T cell." [PMID:21739672, PMID:31570879]
+synonym: "T cell dysfuction" RELATED []
+synonym: "T cell exhaustion" EXACT []
+is_a: GO:0030217 ! T cell differentiation
+intersection_of: GO:0030154 ! cell differentiation
+intersection_of: results_in_acquisition_of_features_of CL:0011025 ! exhausted T cell
+relationship: results_in_acquisition_of_features_of CL:0011025 ! exhausted T cell
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25698" xsd:anyURI
+created_by: rynl
+creation_date: 2023-07-14T22:56:05Z
+
+[Term]
+id: GO:0160093
+name: chordate pharynx development
+namespace: biological_process
+def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903]
+is_a: GO:0060465 ! pharynx development
+intersection_of: GO:0048856 ! anatomical structure development
+intersection_of: results_in_development_of UBERON:0001042 ! chordate pharynx
+relationship: results_in_development_of UBERON:0001042 ! chordate pharynx
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/18285" xsd:anyURI
+created_by: rynl
+creation_date: 2023-08-29T21:05:28Z
+
[Term]
id: GO:1900006
name: positive regulation of dendrite development
@@ -118394,8 +118257,8 @@ id: GO:1901363
name: heterocyclic compound binding
namespace: molecular_function
def: "Binding to heterocyclic compound." [GOC:TermGenie]
-is_a: GO:0005488 ! binding
-intersection_of: GO:0005488 ! binding
+is_a: GO:0036094 ! small molecule binding
+intersection_of: GO:0036094 ! small molecule binding
intersection_of: has_input CHEBI:5686
relationship: has_input CHEBI:5686
created_by: bf
@@ -125194,7 +125057,6 @@ id: GO:1903581
name: regulation of basophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837]
-is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050776 ! regulation of immune response
@@ -125213,7 +125075,6 @@ synonym: "down regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "downregulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "inhibition of basophil degranulation" NARROW [GOC:TermGenie]
-is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0050777 ! negative regulation of immune response
@@ -125233,7 +125094,6 @@ synonym: "activation of basophil degranulation" NARROW [GOC:TermGenie]
synonym: "up regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of basophil degranulation" EXACT [GOC:TermGenie]
synonym: "upregulation of basophil degranulation" EXACT [GOC:TermGenie]
-is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0050778 ! positive regulation of immune response
@@ -125288,6 +125148,7 @@ synonym: "upregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie
is_a: GO:0043306 ! positive regulation of mast cell degranulation
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0050729 ! positive regulation of inflammatory response
+is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002553 ! histamine secretion by mast cell
@@ -125579,7 +125440,7 @@ def: "The process whose specific outcome is the progression of an esophagus over
synonym: "esophageal development" EXACT [MGI:csmith]
synonym: "gullet development" EXACT [GOC:TermGenie]
synonym: "oesophagus development" EXACT [GOC:TermGenie]
-is_a: GO:0048513 ! animal organ development
+is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001043 ! esophagus
relationship: results_in_development_of UBERON:0001043 ! esophagus
@@ -129017,8 +128878,8 @@ is_a: GO:0034703 ! cation channel complex
is_a: GO:0098665 ! serotonin receptor complex
is_a: GO:0098878 ! neurotransmitter receptor complex
intersection_of: GO:0032991 ! protein-containing complex
-intersection_of: capable_of GO:0022850 ! serotonin-gated monoatomic cation-selective channel activity
-relationship: capable_of GO:0022850 ! serotonin-gated monoatomic cation-selective channel activity
+intersection_of: capable_of GO:0022850 ! serotonin-gated monoatomic cation channel activity
+relationship: capable_of GO:0022850 ! serotonin-gated monoatomic cation channel activity
relationship: capable_of_part_of GO:0007210 ! serotonin receptor signaling pathway
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/12942" xsd:anyURI
created_by: bhm
@@ -131643,6 +131504,7 @@ id: GO:1905109
name: regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
+synonym: "regulation of pulmonary blood vessel remodelling" EXACT []
is_a: GO:0060312 ! regulation of blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0101010 ! pulmonary blood vessel remodeling
@@ -131659,6 +131521,7 @@ synonym: "down regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermG
synonym: "down-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "downregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "inhibition of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie]
+synonym: "negative regulation of pulmonary blood vessel remodelling" EXACT []
is_a: GO:0060313 ! negative regulation of blood vessel remodeling
is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
@@ -131673,6 +131536,7 @@ name: positive regulation of pulmonary blood vessel remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie]
+synonym: "positive regulation of pulmonary blood vessel remodelling" EXACT []
synonym: "up regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "up-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
synonym: "upregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie]
@@ -135328,20 +135192,6 @@ relationship: positively_regulates GO:0001707 ! mesoderm formation
created_by: rph
creation_date: 2017-02-03T12:28:38Z
-[Term]
-id: GO:1905905
-name: pharyngeal gland morphogenesis
-namespace: biological_process
-def: "The developmental process by which a pharyngeal gland is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:21868609]
-synonym: "glandulae pharyngeae morphogenesis" RELATED [GOC:TermGenie]
-synonym: "pharynx gland morphogenesis" EXACT [GOC:TermGenie]
-is_a: GO:0022612 ! gland morphogenesis
-intersection_of: GO:0009653 ! anatomical structure morphogenesis
-intersection_of: results_in_morphogenesis_of UBERON:0003295 ! pharyngeal gland
-relationship: results_in_morphogenesis_of UBERON:0003295 ! pharyngeal gland
-created_by: rz
-creation_date: 2017-02-03T14:39:10Z
-
[Term]
id: GO:1905912
name: regulation of calcium ion export across plasma membrane
@@ -135411,7 +135261,7 @@ synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0031326 ! regulation of cellular biosynthetic process
+is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008292 ! acetylcholine biosynthetic process
@@ -135448,7 +135298,7 @@ synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
+is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
@@ -135486,7 +135336,7 @@ synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
+is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
@@ -135998,7 +135848,6 @@ synonym: "os penis development" EXACT [GOC:sl]
synonym: "penile bone development" EXACT [GOC:sl]
synonym: "penis bone development" EXACT [GOC:sl]
is_a: GO:0048608 ! reproductive structure development
-is_a: GO:0060348 ! bone development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006435 ! os penis
relationship: results_in_development_of UBERON:0006435 ! os penis
@@ -138599,6 +138448,7 @@ id: GO:2000504
name: positive regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol]
+synonym: "positive regulation of blood vessel remodelling" EXACT []
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0060312 ! regulation of blood vessel remodeling
intersection_of: GO:0065007 ! biological regulation
@@ -142782,8 +142632,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -142852,17 +142700,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000136
name: closure
@@ -143189,7 +143026,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -143436,36 +143272,6 @@ subset: attribute_slim
synonym: "liquidity" EXACT []
is_a: PATO:0002198 ! quality of a substance
-[Term]
-id: PATO:0001562
-name: decreased mass
-namespace: quality
-alt_id: PATO:0000579
-def: "A mass which is lower than normal or average." [PATO:GVG]
-subset: value_slim
-synonym: "low mass" EXACT []
-synonym: "small mass" EXACT []
-is_a: PATO:0000125 ! mass
-is_a: PATO:0002303 ! decreased object quality
-intersection_of: PATO:0000125 ! mass
-intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
-property_value: RO:0002604 PATO:0001563
-
-[Term]
-id: PATO:0001563
-name: increased mass
-namespace: quality
-alt_id: PATO:0000578
-def: "A mass which is higher than normal or average." [PATO:GVG]
-subset: value_slim
-synonym: "high mass" EXACT []
-synonym: "large mass" EXACT []
-is_a: PATO:0000125 ! mass
-is_a: PATO:0002305 ! increased object quality
-intersection_of: PATO:0000125 ! mass
-intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
-property_value: RO:0002604 PATO:0001562
-
[Term]
id: PATO:0001579
name: contractility
@@ -143767,7 +143573,6 @@ def: "A structural quality inhering in a bearer by virtue of the bearer's having
subset: value_slim
synonym: "sacular" EXACT []
is_a: PATO:0002014 ! structure, cavities
-property_value: IAO:0000118 "sacular" xsd:string {http://purl.obolibrary.org/obo/IAO_scope="EXACT"}
[Term]
id: PATO:0001992
@@ -144217,16 +144022,6 @@ is_a: PATO:0000025 ! composition
relationship: dc-contributor https://orcid.org/0000-0002-9611-1279
creation_date: 2014-02-04T12:38:14Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -144342,19 +144137,6 @@ intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal
relationship: dc-contributor https://orcid.org/0000-0001-9227-0670
creation_date: 2017-12-22T14:16:43Z
-[Term]
-id: PATO:0045030
-name: normal mass
-namespace: quality
-def: "A mass which is relatively normal or average." []
-subset: value_slim
-is_a: PATO:0000125 ! mass
-is_a: PATO:0045001 ! normal object quality
-intersection_of: PATO:0000125 ! mass
-intersection_of: RO:0015010 PATO:0000461 ! has relative magnitude normal
-relationship: dc-contributor https://orcid.org/0000-0001-9227-0670
-creation_date: 2017-12-22T14:16:43Z
-
[Term]
id: PATO:0045050
name: normal size
@@ -148096,6 +147878,26 @@ is_a: CHEBI:36080
is_a: PR:000000001 ! protein
property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P11678
+[Term]
+id: PR:000007204
+name: estrogen receptor
+namespace: protein
+def: "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof." [PRO:DNx]
+comment: Category=gene.
+synonym: "ER" EXACT []
+synonym: "ER-alpha" EXACT []
+synonym: "ESR" RELATED Gene-based []
+synonym: "ESR1" EXACT PRO-short-label [PRO:DNx]
+synonym: "Estr" RELATED Gene-based []
+synonym: "Estra" RELATED Gene-based []
+synonym: "estradiol receptor" EXACT []
+synonym: "NR3A1" RELATED Gene-based []
+synonym: "nuclear receptor subfamily 3 group A member 1" EXACT []
+xref: IUPHARobj:620
+is_a: CHEBI:36080
+is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P03372
+
[Term]
id: PR:000007431
name: high affinity immunoglobulin epsilon receptor subunit alpha
@@ -150634,6 +150436,29 @@ is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000009978 ! lactotransferrin
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
+[Term]
+id: PR:P03372
+name: estrogen receptor (human)
+namespace: protein
+def: "An estrogen receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P03372]
+comment: Category=organism-gene.
+synonym: "ER (human)" EXACT [UniProtKB:P03372]
+synonym: "ER-alpha (human)" EXACT [UniProtKB:P03372]
+synonym: "ESR" RELATED Gene-based [UniProtKB:P03372]
+synonym: "ESR1" RELATED Gene-based [UniProtKB:P03372]
+synonym: "estradiol receptor (human)" EXACT [UniProtKB:P03372]
+synonym: "hESR1" EXACT PRO-short-label [PRO:DNx]
+synonym: "NR3A1" RELATED Gene-based [UniProtKB:P03372]
+synonym: "nuclear receptor subfamily 3 group A member 1 (human)" EXACT [UniProtKB:P03372]
+xref: DTO:00117511
+xref: Reactome:R-HSA-446168 "PR:P03372 located_in GO:0005654"
+xref: Reactome:R-HSA-9020968 "PR:P03372 located_in GO:0005829"
+xref: UniProtKB:P03372
+is_a: PR:000007204 ! estrogen receptor
+is_a: PR:000029067 ! Homo sapiens protein
+intersection_of: PR:000007204 ! estrogen receptor
+intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
+
[Term]
id: PR:P03995
name: glial fibrillary acidic protein (mouse)
@@ -152948,6 +152773,28 @@ is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
+[Term]
+id: PR:P19785
+name: estrogen receptor (mouse)
+namespace: protein
+def: "An estrogen receptor that is encoded in the genome of mouse." [OMA:P19785, PRO:DNx]
+comment: Category=organism-gene.
+synonym: "ER (mouse)" EXACT [UniProtKB:P19785]
+synonym: "ER-alpha (mouse)" EXACT [UniProtKB:P19785]
+synonym: "Esr" RELATED Gene-based [UniProtKB:P19785]
+synonym: "Esr1" RELATED Gene-based [UniProtKB:P19785]
+synonym: "Estr" RELATED Gene-based [UniProtKB:P19785]
+synonym: "Estra" RELATED Gene-based [UniProtKB:P19785]
+synonym: "estradiol receptor (mouse)" EXACT [UniProtKB:P19785]
+synonym: "mESR1" EXACT PRO-short-label [PRO:DNx]
+synonym: "Nr3a1" RELATED Gene-based [UniProtKB:P19785]
+synonym: "nuclear receptor subfamily 3 group A member 1 (mouse)" EXACT [UniProtKB:P19785]
+xref: UniProtKB:P19785
+is_a: PR:000007204 ! estrogen receptor
+is_a: PR:000029032 ! Mus musculus protein
+intersection_of: PR:000007204 ! estrogen receptor
+intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
+
[Term]
id: PR:P20023
name: complement receptor type 2 (human)
@@ -157766,7 +157613,7 @@ relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0001004 {gci_relation="part_of", gci_filler="NCBITaxon:32523", source="PMID:25312359"} ! respiratory system
relationship: part_of UBERON:0001456 {source="FMA", source="ZFA-def"} ! face
relationship: part_of UBERON:0004089 {gci_relation="part_of", gci_filler="NCBITaxon:7776", notes="midface division only makes sense for gnathostomes"} ! midface
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Canine-nose.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Canine-nose.jpg" xsd:anyURI
property_value: UBPROP:0000001 "a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose]." xsd:string {source="Wikipedia:Nose"}
property_value: UBPROP:0000001 "Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047]." xsd:string {source="ZFA:0000047"}
property_value: UBPROP:0000001 "the organ that is specialized for smell and is part of the respiratory system" xsd:string {source="MP:0002233"}
@@ -157826,7 +157673,7 @@ relationship: has_part CL:0000696 {gci_filler="NCBITaxon:117570", gci_relation="
relationship: has_part CL:0002067 {source="PMID:16417468"} ! type A enteroendocrine cell
relationship: part_of UBERON:0000016 ! endocrine pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010406", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000646", ontology="VHOG", source="PMID:7600975 Slack JMW, Developmental biology of the pancreas. Development (1995)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)" xsd:string {source="PMID:16417468"}
@@ -157890,7 +157737,7 @@ relationship: has_part UBERON:0002196 ! adenohypophysis
relationship: has_part UBERON:0002198 ! neurohypophysis
relationship: immediate_transformation_of UBERON:0034875 {source="https://orcid.org/0000-0003-3308-6245"} ! future pituitary gland
relationship: only_in_taxon NCBITaxon:7742 {source="PMID:19084529"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png" xsd:anyURI
property_value: UBPROP:0000001 "An endocrine gland derived from infundibulum of the floor of the diencephalon and an ectodermal dorsal protrusion from the buccal cavity which controls the secretion of many hormones influencing the function of various organs of the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010536", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000118", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000143", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510", source="http://bgee.unil.ch/"}
@@ -157921,8 +157768,8 @@ is_a: UBERON:0004923 ! organ component layer
relationship: composed_primarily_of UBERON:0002384 ! connective tissue
relationship: immediately_deep_to UBERON:0000344 ! mucosa
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: UBPROP:0000007 "submucosal" xsd:string
[Term]
@@ -157970,7 +157817,7 @@ xref: ZFA:0000142
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: part_of UBERON:0001016 ! nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000142", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000429", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"}
@@ -158016,7 +157863,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: contributes_to_morphology_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 {source="FMA", source="MA", source="WP", source="ZFA-modified-from-isa"} ! autonomic nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
property_value: UBPROP:0000001 "Part of the autonomic nervous system which has opposing physiological effects of the sympathetic nervous system. Examples include decreasing the heart rate or dilating the blood vessels.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010488", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "In mammals, the autonomic nervous system is divided into two contrasting, antagonistic systems of control over visceral activity: the sympathetic system and the parasympathetic system (reference 1); In general, the teleosts may be considered phylogenetically the first class of vertebrates in which the heart is regulated by both sympathetic and parasympathetic neural pathways (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000755", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.634, DOI:10.1016/S0306-4530(98)00057-2 Porges SW, Love: an emergent property of the mammalian autonomic nervous system. Psychoneuroendocrinology (1998)", source="http://bgee.unil.ch/"}
@@ -158079,7 +157926,7 @@ xref: ZFA:0001576
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: contributes_to_morphology_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 {source="FMA", source="MA", source="ZFA-modified-from-isa"} ! autonomic nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png" xsd:anyURI
property_value: UBPROP:0000001 "Part of the autonomic nervous system which has opposing physiological effects of the parasympathetic nervous system. Examples include increasing the heart rate or constricting the blood vessels.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010487", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000384", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000384", ontology="VHOG", source="ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.461-463", source="http://bgee.unil.ch/"}
@@ -158114,8 +157961,8 @@ is_a: UBERON:0034944 {source="FMA"} ! zone of organ
relationship: has_part UBERON:0001003 ! skin epidermis
relationship: has_part UBERON:0002067 ! dermis
relationship: part_of UBERON:0002097 ! skin of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg" xsd:anyURI
property_value: IAO:0000232 "Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee" xsd:string
property_value: UBPROP:0000003 "(...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000860", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive" xsd:string
@@ -158335,7 +158182,7 @@ intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
[Term]
id: UBERON:0000021
@@ -158452,7 +158299,7 @@ relationship: has_part UBERON:0002391 ! lymph
relationship: in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of UBERON:0002465 ! lymphoid system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Illu_lymph_node_structure.png" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/650" xsd:anyURI
property_value: UBPROP:0000003 "Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001273", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.630", source="http://bgee.unil.ch/"}
@@ -158475,7 +158322,7 @@ is_a: UBERON:0004923 ! organ component layer
relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue
relationship: immediately_deep_to UBERON:0000483 ! epithelium
relationship: part_of UBERON:0000344 ! mucosa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg" xsd:anyURI
[Term]
id: UBERON:0000031
@@ -158641,7 +158488,7 @@ intersection_of: has_part UBERON:0000039 ! follicular antrum
relationship: develops_from UBERON:0000036 ! secondary ovarian follicle
relationship: has_component UBERON:0005170 ! granulosa cell layer
relationship: has_part UBERON:0000039 ! follicular antrum
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG" xsd:anyURI
[Term]
id: UBERON:0000038
@@ -158674,7 +158521,7 @@ relationship: located_in UBERON:0000039 ! follicular antrum
relationship: part_of UBERON:0001305 ! ovarian follicle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: surrounds CL:0000025 ! egg cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI
property_value: UBPROP:0000008 "Generally, larger species such as ovine, equine, porcine, human, and bovine have larger follicles, with the fluid comprising a substantial proportion of the volume of the follicles at ovulation (estimated at >95% in bovine [3]). Smaller species such as rats and mice have smaller follicles with fractionally less follicular fluid[20164441]" xsd:string
property_value: UBPROP:0000010 "The follicular fluid contains sex steroids, glycoprotein hormones, plasma proteins, mucopolysaccharides, and enzymes and is rich in hyaluronic acid." xsd:string
@@ -158725,8 +158572,8 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: has_part UBERON:0001136 ! mesothelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0000060 ! anatomical wall
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: UBPROP:0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005425", ontology="TAO", source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000001 "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" xsd:string {source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." xsd:string {external_ontology="FMA"}
@@ -158765,7 +158612,7 @@ relationship: connects UBERON:0001630 ! muscle organ
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0002204 {source="OG"} ! musculoskeletal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000073", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000003 "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001286", ontology="VHOG", source="DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" xsd:string {external_ontology="FMA"}
@@ -158823,7 +158670,7 @@ intersection_of: extends_fibers_into UBERON:0002261 ! dorsal root of spinal cord
relationship: develops_from UBERON:0003083 {source="DOI:10.1101/gr.157586.113", source="ZFA", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! trunk neural crest
relationship: extends_fibers_into UBERON:0001780 ! spinal nerve
relationship: extends_fibers_into UBERON:0002261 ! dorsal root of spinal cord
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/71/DRG_Chicken_e7.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/71/DRG_Chicken_e7.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2644" xsd:string
property_value: UBPROP:0000001 "Trunk ganglion which is located adjacent to the spine on a dorsal root and contains the cell bodies of afferent sensory nerves.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000200", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000222", ontology="VHOG", source="DOI:10.1002/1097-0185(20000615)261:3<111::AID-AR6>3.0.CO;2-F Butler AB, Chordate evolution and the origin of craniates: An old brain in a new head. AnaT Rec (New Anat) (2000)", source="http://bgee.unil.ch/"}
@@ -158933,7 +158780,7 @@ relationship: extends_fibers_into UBERON:0002206 ! mammillary body
relationship: extends_fibers_into UBERON:0002663 ! septal nuclear complex
relationship: part_of UBERON:0002421 {source="NIFSTD"} ! hippocampal formation
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/21/Gray747.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/21/Gray747.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
@@ -158965,7 +158812,7 @@ xref: Wikipedia:Macula_of_retina
is_a: UBERON:0000064 ! organ part
disjoint_from: UBERON:0000054 ! macula
relationship: part_of UBERON:0000966 ! retina
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
[Term]
id: UBERON:0000054
@@ -159047,7 +158894,7 @@ relationship: develops_from UBERON:0005081 {source="GO"} ! ureter ureteric bud
relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism
relationship: part_of UBERON:0036295 ! renal pelvis/ureter
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010254", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000605", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000605", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", source="http://bgee.unil.ch/"}
@@ -159093,7 +158940,7 @@ relationship: continuous_with UBERON:0001255 ! urinary bladder
relationship: develops_from UBERON:0000164 {notes="pelvic part of UG sinus gives rise to prostatic and membranous parts of urethra", source="Wikipedia"} ! primitive urogenital sinus
relationship: develops_from UBERON:0013241 {source="Wikipedia"} ! embryonic urethral groove
relationship: part_of UBERON:0001556 ! lower urinary tract
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: UBPROP:0000007 "urethral" xsd:string
property_value: UBPROP:0000008 "In human males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter and emerges above the vaginal opening." xsd:string
@@ -159243,7 +159090,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0002095 {source="PMID:28192867"} ! mesentery
disjoint_from: UBERON:0034921 ! multi organ part structure
@@ -159513,8 +159359,8 @@ relationship: develops_from UBERON:0005749 ! glomerular tuft
relationship: part_of UBERON:0001229 {source="FMA", source="MA"} ! renal corpuscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: surrounded_by UBERON:0001230 ! glomerular capsule
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg" xsd:anyURI
property_value: UBPROP:0000012 "ZFA - The multi-tissue structure where the glomerular basement membrane supported by mesonephric podocytes filters blood from the glomerular capillaries. GUDMAP: 'Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle.' - here the glomerulus is part of the capsule?" xsd:string {external_ontology="ZFA"}
creation_date: 2009-06-18T09:26:37Z
@@ -159560,7 +159406,7 @@ xref: Wikipedia:External_ectoderm
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0000924 {source="EHDAA2"} ! ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
property_value: editor_note "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" xsd:string
property_value: RO:0002171 UBERON:0002346
property_value: UBPROP:0000011 "(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis" xsd:string
@@ -159679,7 +159525,7 @@ xref: ZFA:0000529
is_a: UBERON:0002113 ! kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0002120 ! pronephros
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray986.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray986.png" xsd:anyURI
property_value: UBPROP:0000001 "A kidney formed of nephric tubules arising in the middle region of the nephric ridge; a transient embryonic stage that replaces the pronephros, but is itself replaced by the adult metanephros [in mammals; in fishes and amphibians it is the adult kidney]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000038", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Organ that is the definitive adult kidney. It replaces the earlier pronephros, which degenerates as the mesonephros becomes functional in feeding stage tadpoles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010384", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates. (...) In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000038", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.639", source="http://bgee.unil.ch/"}
@@ -159802,7 +159648,7 @@ relationship: existence_starts_during UBERON:0000107 ! cleavage stage
relationship: has_part CL:0000353 ! blastoderm cell
relationship: part_of UBERON:0004716 {source="EHDAA2"} ! conceptus
relationship: surrounded_by UBERON:0000086 ! zona pellucida
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: UBPROP:0000012 "EHDAA2 has embryo starting later" xsd:string {external_ontology="EHDAA2"}
[Term]
@@ -159841,7 +159687,7 @@ relationship: bounding_layer_of CL:0000023 ! oocyte
relationship: has_part CHEBI:17089
relationship: part_of UBERON:0000992 ! ovary
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI
property_value: UBPROP:0000003 "Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000720", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.159", source="http://bgee.unil.ch/"}
[Term]
@@ -159870,7 +159716,7 @@ xref: Wikipedia:Inner_cell_mass
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000358 {source="Wikipedia"} ! blastocyst
relationship: surrounded_by UBERON:0000088 {source="Wikipedia"} ! trophoblast
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
property_value: UBPROP:0000001 "A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred.The ICM lies within the blastocyst cavity and is entirely surrounded by the single layer of cells called trophoblast. [Wikipedia:Inner_cell_mass]" xsd:string
@@ -159903,7 +159749,7 @@ relationship: composed_primarily_of CL:0000351 ! trophoblast cell
relationship: develops_from UBERON:0004345 {source="MP-def", source="PMID:19829370"} ! trophectoderm
relationship: part_of UBERON:0000358 ! blastocyst
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
property_value: UBPROP:0000001 "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP]" xsd:string {date_retrieved="2012-08-23", external_class="MP:0005031", external_class_label="trophoblast layer", ontology="MP", source="ISBN:0-683-40008-8"}
property_value: UBPROP:0000007 "trophoblastic" xsd:string
property_value: UBPROP:0000011 "The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta" xsd:string {source="PMID:19829370"}
@@ -159928,7 +159774,7 @@ xref: UMLS:C1283997 {source="ncithesaurus:Bilaminar_Embryonic_Disc"}
xref: Wikipedia:Bilaminar_disc
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000087 {source="Wikipedia"} ! inner cell mass
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
[Term]
id: UBERON:0000092
@@ -160173,7 +160019,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -160387,7 +160233,7 @@ is_a: UBERON:0005153 {source="GO:0060441"} ! epithelial bud
relationship: adjacent_to UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
relationship: develops_from UBERON:0005597 ! lung primordium
relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png" xsd:anyURI
property_value: editor_note "clarify successors - include bronchi?" xsd:string
[Term]
@@ -160440,7 +160286,7 @@ relationship: bounding_layer_of UBERON:0001019 ! nerve fasciculus
relationship: has_part GO:0005581 ! collagen trimer
relationship: located_in UBERON:0000124 ! epineurium
relationship: part_of UBERON:0003209 ! blood nerve barrier
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray636.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray636.png" xsd:anyURI
property_value: UBPROP:0000001 "Connective tissue surrounding a fascicle[Wikipedia:Perineurium]." xsd:string {source="Wikipedia:Perineurium"}
property_value: UBPROP:0000007 "perineurial" xsd:string
property_value: UBPROP:0000012 "consider FBbt:00007090 (perineurium): The outer two layers of glial cells that cover the central nervous system and the nerves. The outer layer is the perineurial sheath (sometimes referred to as the perineurial sheath outer layer); the inner layer is the sub-perineural glial sheath (sometimes referred to as the perineurial sheath inner layer)" xsd:string {external_ontology="FBbt"}
@@ -160477,7 +160323,7 @@ xref: Wikipedia:Epineurium
is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue
relationship: part_of UBERON:0000010 ! peripheral nervous system
relationship: surrounds UBERON:0001021 ! nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray636.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray636.png" xsd:anyURI
property_value: UBPROP:0000001 "outermost layer of connective tissue surrounding a peripheral nerve. It includes the blood vessels supplying the nerve. It consists of adipose tissue and fibrocollagenous tissues[Wikipedia:Epineurium]." xsd:string {source="Wikipedia:Epineurium"}
[Term]
@@ -160520,7 +160366,7 @@ is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve
relationship: extends_fibers_into UBERON:0001785 ! cranial nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI
[Term]
id: UBERON:0000127
@@ -160662,7 +160508,7 @@ relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embr
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001353 ! anal region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI
property_value: editor_note "requires alignment with EHDAA2 and complete developmental relationships" xsd:string
[Term]
@@ -160796,7 +160642,7 @@ relationship: contributes_to_morphology_of UBERON:0000163 ! embryonic cloaca
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0000163 {source="MP-def"} ! embryonic cloaca
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
property_value: UBPROP:0000001 "The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000414", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/urogenital+sinus"}
property_value: UBPROP:0000003 "In mammals the lowly monotremes still have a cloaca. Higher types have done away with this structure and have a separate anal outlet for the rectum. The monotreme cloaca shows the initiation of this subdivision. The cloaca has such includes only the distal part, roughly comparable to the proctodeum. The more proximal part is divided into (1) a large dorsal passage into which the intestine opens, the coprodeum, and (2) a ventral portion, the urodeum with which the bladder connects. (...) the development of the placental mammals recapitulates in many respects the phylogenetic story. In the sexually indifferent stage of placental mammal there is a cloaca. While the indifferent stage still persists, a septum develops, and extends out to the closing membrane. This divides the cloaca into two chambers: a coprodeum continuous with the gut above, and a urodeum or urogenital sinus below.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000414", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970)p.388-89 and Figure 300", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000013 "the term 'urogenital sinus' may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal" xsd:string {source="MP"}
@@ -160862,7 +160708,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -161244,8 +161090,8 @@ relationship: connected_to UBERON:0001679 {gci_relation="part_of", gci_filler="N
relationship: overlaps UBERON:0001697 ! orbit of skull
relationship: part_of UBERON:0003113 {source="cjm"} ! dermatocranium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png" xsd:anyURI
property_value: UBPROP:0000008 "fused in humans, paired in other animals" xsd:string
property_value: UBPROP:0000011 "In the mouse the parietal originates from cephalic paraxial mesoderm (Jiang 2000; Morriss-Kay 2001), whereas in the chicken it is traced back to either mesodermal (Noden 1978) or neural crest (Couly 1992, 1993)." xsd:string
@@ -161278,7 +161124,7 @@ xref: ZFA:0001675
is_a: UBERON:0000062 ! organ
relationship: has_part UBERON:0002384 ! connective tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
property_value: UBPROP:0000001 "Nonparenchymatous organ that primarily consists of dense connective tissue aggregated into fasciculi by connective tissue. Examples: sutural ligament, radiate sternocostal ligament, ligament of liver, ovarian ligament[FMA][FMA:21496]." xsd:string {source="FMA:21496"}
property_value: UBPROP:0000001 "Portion of connective tissue that connects bone or cartilage.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001682", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000003 "Compared with their Ediacarian predecessor, Cambrian animals in general were characterized by their much stouter bodies. The stoutness of the body is likely due to the formation of ligaments and tendons, which in turn requires the crosslinking of collagen triple helices.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001272", ontology="VHOG", source="PMID:8710894 Ohno S, The notion of the Cambrian pananimalia genome. PNAS (1996)", source="http://bgee.unil.ch/"}
@@ -161339,7 +161185,7 @@ relationship: connects UBERON:0001092 ! vertebral bone 1
relationship: connects UBERON:0001676 ! occipital bone
relationship: in_lateral_side_of UBERON:0006072 {source="FMA-abduced-lr"} ! cervical region of vertebral column
relationship: part_of UBERON:0011138 ! postcranial axial skeletal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI
[Term]
id: UBERON:0000304
@@ -161396,7 +161242,7 @@ relationship: has_part UBERON:0003262 ! amniotic mesoderm
relationship: only_in_taxon NCBITaxon:32524 {source="Hymans"} ! Amniota
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: surrounds UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e7/Gray14.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e7/Gray14.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb" xsd:string
property_value: UBPROP:0000001 "A thin but tough extraembryonic membrane of reptiles, birds and mammals that lines the chorion and contains the fEtus and the amniotic fluid around it. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000721", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000721", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"}
@@ -161422,7 +161268,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -161465,7 +161311,7 @@ xref: UMLS:C0006141 {source="ncithesaurus:Breast"}
xref: Wikipedia:Breast
is_a: UBERON:0034929 ! external soft tissue zone
relationship: part_of UBERON:0001443 ! chest
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Closeup_of_female_breast.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Closeup_of_female_breast.jpg" xsd:anyURI
property_value: UBPROP:0000008 "The breasts of a female primate's body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's." xsd:string {source="WP,unvetted"}
[Term]
@@ -161552,8 +161398,8 @@ relationship: adjacent_to UBERON:0002362 ! arachnoid mater
relationship: location_of UBERON:0001359 ! cerebrospinal fluid
relationship: location_of UBERON:0001981 {source="ISBN:0471888893"} ! blood vessel
relationship: part_of UBERON:0010743 ! meningeal cluster
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray769-en.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray769.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray769-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray769.png" xsd:anyURI
[Term]
id: UBERON:0000316
@@ -161828,8 +161674,8 @@ is_a: UBERON:0004923 ! organ component layer
relationship: has_part UBERON:0000483 ! epithelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: RO:0002171 UBERON:0000009
property_value: UBPROP:0000007 "mucosal" xsd:string
property_value: UBPROP:0000012 "FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately" xsd:string {external_ontology="FMA"}
@@ -161912,7 +161758,7 @@ xref: UMLS:C0023715 {source="ncithesaurus:Limbic_System"}
xref: Wikipedia:Limbic_system
is_a: UBERON:0011216 ! organ system subdivision
relationship: part_of UBERON:0001890 ! forebrain
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5c/Brain_limbicsystem.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/5c/Brain_limbicsystem.jpg" xsd:anyURI
property_value: editor_note "obsoletion proposes. The current part_of children were chosen as the intersection of what is stated in wikipedia and in the FMA. NIF: We are including Limbic System because it is still used by neuroscientists and others, but as a data annotation term, it is very poor because it is not a clearly defined entity." xsd:string
[Term]
@@ -162025,7 +161871,7 @@ relationship: has_part UBERON:0000087 ! inner cell mass
relationship: has_part UBERON:0000088 ! trophoblast
relationship: only_in_taxon NCBITaxon:32525 ! Theria
relationship: part_of UBERON:0000307 ! blastula
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
property_value: editor_note "Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm)" xsd:string
[Term]
@@ -162084,7 +161930,7 @@ relationship: contributes_to_morphology_of UBERON:0002113 ! kidney
relationship: has_part UBERON:0004200 ! kidney pyramid
relationship: part_of UBERON:0002113 ! kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb" xsd:string
@@ -162119,7 +161965,7 @@ xref: Wikipedia:Urothelium
is_a: UBERON:0000486 ! multilaminar epithelium
is_a: UBERON:0005911 ! endo-epithelium
relationship: part_of UBERON:0001008 ! renal system
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/91/Harnblase_Urothel.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/91/Harnblase_Urothel.png" xsd:anyURI
property_value: UBPROP:0000007 "urothelial" xsd:string
[Term]
@@ -162150,10 +161996,34 @@ xref: VHOG:0001175
xref: Wikipedia:Corpus_striatum
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0002420 {source="MA"} ! basal ganglion
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray656.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray656.png" xsd:anyURI
property_value: UBPROP:0000003 "Thus, certain telencephalic characters - such as the presence of a pallium divided into lateral, dorsal, and medial formations and a subpallium divided into striatum and septum - appear to characterize all vertebrates. They are primitive characters and are homologous among all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001175", ontology="VHOG", source="DOI:10.1146/annurev.ne.04.030181.001505, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.487 Figure 14-10", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000013 "The term has been used in a few different ways: * It is a pair of nuclear masses which form the basal ganglia, along with the subthalamic nucleus and the substantia nigra. * It may also refer to both the basal ganglia and internal capsule collectively.[2]" xsd:string
+[Term]
+id: UBERON:0000371
+name: syncytiotrophoblast
+namespace: uberon
+def: "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." [http://embryology.med.unsw.edu.au/Notes/placenta5.htm, Wikipedia:Syncytiotrophoblast]
+synonym: "syncitiotrophoblast" RELATED []
+synonym: "syncitiotrophoblastus" RELATED LATIN [Wikipedia:Syncytiotrophoblast]
+synonym: "syncytial trophoblast" EXACT [FMA:83040]
+synonym: "syntrophoblast" RELATED []
+synonym: "syntrophoblast layer" EXACT [ISBN:0073040584]
+xref: BTO:0001335
+xref: EHDAA:129
+xref: EHDAA:91
+xref: EMAPA:16068
+xref: FMA:83040
+xref: NCIT:C33918
+xref: SCTID:256965005
+xref: UMLS:C1135936 {source="ncithesaurus:Syncytiotrophoblast"}
+xref: Wikipedia:Syncytiotrophoblast
+is_a: UBERON:0002050 {source="FMA"} ! embryonic structure
+relationship: composed_primarily_of CL:0000525 ! syncytiotrophoblast cell
+relationship: part_of UBERON:0004364 {source="EMAPA"} ! ectoplacental cone
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray36.png" xsd:anyURI
+
[Term]
id: UBERON:0000375
name: mandibular nerve
@@ -162195,7 +162065,7 @@ xref: Wikipedia:Mandibular_nerve
is_a: UBERON:0001021 ! nerve
relationship: branching_part_of UBERON:0001645 ! trigeminal nerve
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray781.png" xsd:anyURI
[Term]
id: UBERON:0000376
@@ -162241,7 +162111,7 @@ intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: contributes_to_morphology_of UBERON:0002103 ! hindlimb
relationship: has_skeleton UBERON:0015052 ! femur endochondral element
relationship: part_of UBERON:0000978 {source="MA"} ! leg
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4b/Gray1238.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4b/Gray1238.png" xsd:anyURI
property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000349", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group." xsd:string {seeAlso="https://github.com/obophenotype/uberon/issues/61"}
@@ -162282,7 +162152,7 @@ xref: Wikipedia:Maxillary_nerve
is_a: UBERON:0001021 ! nerve
relationship: branching_part_of UBERON:0001645 ! trigeminal nerve
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png" xsd:anyURI
property_value: UBPROP:0000001 "Medial ramus (sensory) of the trigeminal nerve.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000002 "relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO"}
@@ -162321,7 +162191,7 @@ relationship: attaches_to_part_of UBERON:0001723 ! tongue
relationship: contributes_to_morphology_of UBERON:0001723 ! tongue
relationship: develops_from UBERON:0005594 {source="FEED:rd", source="ISBN:1607950324"} ! head somite
relationship: part_of UBERON:0000165 ! mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Gray1019.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Gray1019.png" xsd:anyURI
property_value: UBPROP:0000003 "The lamprey head contains another group of muscles, the epi- and hypo-branchial muscles (EBM and HBM), derivatives of anterior trunk myotomes. (...) The origin and the migration pattern of HBM precursors are very similar to that of the gnathostome MPP, especially to that of the tongue muscle precursors. Other evidence of homology of lamprey HBM to the gnathostome tongue muscle is that HBM is innervated by the nerve termed the hypoglossal nerve based on its morphological position associated with the head/trunk interface. (...) The HBM-specific expression of the LampPax3/7 gene is consistent with the homology of this muscle to the gnathostome tongue muscle, or to the hypobranchial series as a whole (including the infrahyoid and possibly the diaphragm in mammals).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001390", ontology="VHOG", source="DOI:10.1002/dvdy.20587 Kusakabe R, Kuratani S, Evolution and developmental patterning of the vertebrate skeletal muscles: perspectives from the lamprey. Developmental Dynamics (2005)", source="http://bgee.unil.ch/"}
[Term]
@@ -162520,7 +162390,7 @@ relationship: extends_fibers_into UBERON:0004727 ! cochlear nerve
relationship: located_in UBERON:0006723 {notes="cell bodies", source="BTO-modified", source="Wikipedia"} ! cochlear modiolus
relationship: part_of UBERON:0002827 ! vestibulocochlear ganglion
relationship: part_of UBERON:0016490 ! auditory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray903.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray903.png" xsd:anyURI
property_value: editor_note "in BTO this is part of the cochlear modiolus, but this leads to the CG being in both the nervous and skeletal systems" xsd:string
[Term]
@@ -162629,7 +162499,7 @@ xref: SCTID:278940000
xref: Wikipedia:Nasal_vestibule
is_a: UBERON:0002553 ! anatomical cavity
relationship: part_of UBERON:0001707 ! nasal cavity
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray994.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray994.png" xsd:anyURI
[Term]
id: UBERON:0000403
@@ -162657,8 +162527,8 @@ relationship: has_part UBERON:0002515 ! periosteum
relationship: overlaps UBERON:0001084 ! skin of head
relationship: overlaps UBERON:0006661 ! epicranial aponeurosis
relationship: part_of UBERON:0000033 {source="BTO"} ! head
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Layers_of_the_scalp_and_meninges.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/eb/Double_cowlick.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Layers_of_the_scalp_and_meninges.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/e/eb/Double_cowlick.jpg" xsd:anyURI
[Term]
id: UBERON:0000407
@@ -162682,7 +162552,7 @@ is_a: UBERON:0000062 ! organ
is_a: UBERON:0015212 ! lateral structure
relationship: in_lateral_side_of UBERON:0000013 {source="FMA-abduced-lr"} ! sympathetic nervous system
relationship: part_of UBERON:0000013 ! sympathetic nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray847.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray847.png" xsd:anyURI
[Term]
id: UBERON:0000409
@@ -162701,7 +162571,7 @@ intersection_of: has_part CL:0000313 ! serous secreting cell
relationship: has_part CL:0000313 ! serous secreting cell
relationship: has_part UBERON:0013232 ! serous acinus
relationship: produces UBERON:0007794 ! secretion of serous gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI
property_value: UBPROP:0000001 "glands that secrete watery albuminous material that often contains enzymes[MP:0008052]." xsd:string {source="MP:0008052"}
[Term]
@@ -162771,7 +162641,7 @@ xref: Wikipedia:Dermal_papillae
is_a: UBERON:0000479 ! tissue
relationship: composed_primarily_of CL:0000057 ! fibroblast
relationship: part_of UBERON:0001992 ! papillary layer of dermis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/34/Skin.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/34/Skin.jpg" xsd:anyURI
property_value: editor_note "consider adding grouping class for TAO:0001995 ! papilla" xsd:string
property_value: UBPROP:0000008 "In humans, at the surface of the skin in hands and feet, they appear as epidermal or papillary ridges (colloquially known as fingerprints)" xsd:string
property_value: UBPROP:0000009 "Blood vessels in the dermal papillae nourish all hair follicles and bring nutrients and oxygen to the lower layers of epidermal cells." xsd:string
@@ -162799,7 +162669,7 @@ intersection_of: has_part CL:0000319 ! mucus secreting cell
relationship: capable_of GO:0070254 ! mucus secretion
relationship: has_part CL:0000319 ! mucus secreting cell
relationship: produces UBERON:0000912 ! mucus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI
property_value: UBPROP:0000008 "In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong]" xsd:string {scope="NCBITaxon:8292", source="ISBN:0073040584"}
[Term]
@@ -163454,7 +163324,7 @@ disjoint_from: UBERON:0000992 ! ovary
disjoint_from: UBERON:0009117 ! indifferent gonad
relationship: develops_from UBERON:0009117 ! indifferent gonad
relationship: in_lateral_side_of UBERON:0000468 {gci_relation="part_of", gci_filler="NCBITaxon:7742", notes="vertebrates"} ! multicellular organism
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Gray1144.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Gray1144.png" xsd:anyURI
property_value: UBPROP:0000001 "Male reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000598", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000252", ontology="VHOG", source="DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "testicular" xsd:string
@@ -163505,7 +163375,7 @@ is_a: UBERON:0000990 ! reproductive system
intersection_of: UBERON:0000990 ! reproductive system
intersection_of: part_of UBERON:0003100 ! female organism
relationship: part_of UBERON:0003100 ! female organism
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI
property_value: UBPROP:0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000726", ontology="VHOG", source="ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", source="http://bgee.unil.ch/"}
[Term]
@@ -163750,7 +163620,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -163778,7 +163648,7 @@ xref: XAO:0004009
xref: ZFA:0001497
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010077 ! cuboidal epithelium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png" xsd:anyURI
property_value: editor_note "needs to be synchronized with CL - there is no distinct cuboidal cell in CL" xsd:string
[Term]
@@ -163810,7 +163680,7 @@ xref: XAO:0004008
xref: ZFA:0001496
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0012274 ! columnar epithelium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png" xsd:anyURI
[Term]
id: UBERON:0000486
@@ -163866,7 +163736,7 @@ is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: has_part CL:0000076 ! squamous epithelial cell
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"}
[Term]
@@ -164085,7 +163955,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -164160,7 +164030,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -164200,8 +164070,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -164247,7 +164117,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -164286,7 +164156,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -164363,7 +164233,7 @@ intersection_of: UBERON:0001630 ! muscle organ
intersection_of: part_of UBERON:0004467 ! musculature of pharynx
relationship: contributes_to_morphology_of UBERON:0001015 ! musculature
relationship: part_of UBERON:0004467 ! musculature of pharynx
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray1030.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray1030.png" xsd:anyURI
property_value: UBPROP:0000001 "A pharyngeal muscle is any muscle that forms part of the pharynx[GO]." xsd:string {date_retrieved="2012-06-30", external_class="GO:0043282", notes="does not quite work for some muscles such as stylopharyngeus", ontology="GO", source="GOC:go_curators"}
property_value: UBPROP:0000202 FMA:67169
@@ -164499,7 +164369,7 @@ relationship: never_in_taxon NCBITaxon:7955 {source="ZFA"}
relationship: never_in_taxon NCBITaxon:9259 {source="Wikipedia"}
relationship: only_in_taxon NCBITaxon:7776 {notes="absent in lampreys and hagfishes", source="ISBN:0073040584"} ! Gnathostomata
relationship: part_of UBERON:0001041 ! foregut
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg" xsd:anyURI
property_value: UBPROP:0000001 "Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000579", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000408", ontology="VHOG", source="DOI:10.1046/j.1525-142x.2000.00076.x Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM, Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evolution and development (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa" xsd:string {source="WP:Stomach#In_other_animals"}
@@ -164583,7 +164453,7 @@ is_a: UBERON:0013768 ! great vessel of heart
relationship: connected_to UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0010191 {source="EHDAA2"} ! aortic system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg" xsd:anyURI
property_value: editor_note "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." xsd:string {source="WP"}
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -164856,8 +164726,8 @@ relationship: part_of UBERON:0000203 {source="GO", source="ISBN:0471888893"} ! p
relationship: part_of UBERON:0005401 {source="FMA", source="MA"} ! cerebral hemisphere gray matter
relationship: present_in_taxon NCBITaxon:117569
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Cerebral_Cortex_location.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Cerebral_Cortex_location.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg" xsd:anyURI
property_value: IAO:0000232 "We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus)." xsd:string
property_value: UBPROP:0000001 "The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]." xsd:string {source="Wikipedia:Cerebral_cortex"}
property_value: UBPROP:0000003 "Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000722", ontology="VHOG", source="DOI:10.1111/j.1749-6632.1969.tb20437.x Kruger L, Experimental analyses of the reptilian nervous system. Annals of the New York Academy of Sciences (1969)", source="http://bgee.unil.ch/"}
@@ -164877,7 +164747,7 @@ is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: has_quality PATO:0002124 ! laminar
relationship: has_quality PATO:0002124 ! laminar
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
property_value: editor_note "TODO - merge with cell layer?" xsd:string
property_value: UBPROP:0000007 "laminar" xsd:string
@@ -164944,7 +164814,7 @@ intersection_of: extends_fibers_into UBERON:0001908 ! optic tract
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II
relationship: extends_fibers_into UBERON:0001908 ! optic tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The point at which fibers of the optic nerves cross.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010622", ontology="AAO", source="AAO:DSM"}
property_value: UBPROP:0000003 "The chiasm has been studied in great detail in some animals, while in others relatively little or nothing is known. Although there are some gross architectural features that are conserved within some animals, such as birds and fish, the general picture is one of diversity. This review will attempt to consider the key features of such diversity of chiasmatic organisation in vertebrates and the mechanisms that sculpt them from the limited literature that is available. However, as so much research has been undertaken on the structure and development of the chiasm in laboratory animals, any review must consider the information that has been gleaned from them and hope that future studies will determine whether the features revealed in these animals, and the underlying mechanisms that generate them, have a common vertebrate plan.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000190", ontology="VHOG", source="DOI:10.1016/j.preteyeres.2005.04.005 Jeffery G, Erskine L, Variations in the architecture and development of the vertebrate optic chiasm. Progress in retinal and eye research (2005)", source="http://bgee.unil.ch/"}
@@ -164976,7 +164846,7 @@ intersection_of: UBERON:0001807 ! paravertebral ganglion
intersection_of: part_of UBERON:0004863 ! thoracic sympathetic nerve trunk
relationship: extends_fibers_into UBERON:0018679 ! thoracic splanchnic nerve
relationship: part_of UBERON:0004863 ! thoracic sympathetic nerve trunk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray849.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray849.png" xsd:anyURI
[Term]
id: UBERON:0000962
@@ -165001,7 +164871,7 @@ is_a: UBERON:0001780 ! spinal nerve
intersection_of: UBERON:0001780 ! spinal nerve
intersection_of: extends_fibers_into UBERON:0002726 ! cervical spinal cord
relationship: extends_fibers_into UBERON:0002726 ! cervical spinal cord
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png" xsd:anyURI
[Term]
id: UBERON:0000963
@@ -165064,7 +164934,7 @@ relationship: part_of UBERON:0001801 {source="MA"} ! anterior segment of eyeball
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: part_of UBERON:0012430 {source="FMA-isa"} ! tunica fibrosa of eyeball
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000007 "corneal" xsd:string
property_value: UBPROP:0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" xsd:string
@@ -165169,7 +165039,7 @@ relationship: never_in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of UBERON:0001802 ! posterior segment of eyeball
relationship: part_of UBERON:0019207 ! chorioretinal region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000152", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "retinal" xsd:string
@@ -165260,7 +165130,7 @@ relationship: anteriorly_connected_to UBERON:0000033 ! head
relationship: only_in_taxon NCBITaxon:8287 ! Sarcopterygii
relationship: part_of UBERON:0007811 ! craniocervical region
relationship: posteriorly_connected_to UBERON:0002100 ! trunk
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg" xsd:anyURI
property_value: IAO:0000232 "true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck." xsd:string
property_value: RO:0002174 NCBITaxon:32443 {source="ISBN:9780674021839"}
property_value: UBPROP:0000007 "cervical" xsd:string
@@ -165302,7 +165172,7 @@ relationship: never_in_taxon NCBITaxon:8570 {source="Wikipedia"}
relationship: only_in_taxon NCBITaxon:32523 {source="ISBN:0073040584"} ! Tetrapoda
relationship: part_of UBERON:0003252 {source="FMA"} ! thoracic rib cage
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/12/Illu_thoracic_cage.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/12/Illu_thoracic_cage.jpg" xsd:anyURI
property_value: editor_note "in EMAPA and EHDAA2 this is part of the skeleton of pectoral girdle; the classic def of pectoral girdle (see WP) excludes the rib cage and sternum" xsd:string
property_value: UBPROP:0000001 "Single element that constitutes the postzonal area of the pectoral girdle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000765", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: part_of postzonal element (AAO:0000938)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000765", ontology="AAO"}
@@ -165351,7 +165221,7 @@ relationship: develops_from UBERON:0006245 {evidence="definitional"} ! humerus c
relationship: overlaps UBERON:0001470 ! glenohumeral joint
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: proximally_connected_to UBERON:0007831 ! pectoral girdle skeleton
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/67/Illu_upper_extremity.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Paired, elongate, cylindrical bones of endochondral origin that extend from the pectoral girdle to the elbows.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000679", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001158", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "humeral" xsd:string
@@ -165394,7 +165264,7 @@ relationship: has_quality PATO:0001748 ! invaginated
relationship: only_in_taxon NCBITaxon:32524 ! Amniota
relationship: part_of UBERON:0009778 {source="https://github.com/obophenotype/uberon/issues/86"} ! pleural sac
relationship: present_in_taxon NCBITaxon:8782 {source="ISBN:978-0030223693", source="https://orcid.org/0000-0003-3308-6245"} ! Aves
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI
property_value: UBPROP:0000001 "The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000394", ontology="VHOG", source="ISBN:0124020607", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "pleural" xsd:string
property_value: UBPROP:0000012 "In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86" xsd:string
@@ -165463,7 +165333,7 @@ intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
relationship: develops_from UBERON:0010849 ! tibia cartilage element
relationship: preaxialmost_part_of UBERON:0010720 ! hindlimb zeugopod skeleton
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray260.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2a/Gray260.png" xsd:anyURI
property_value: UBPROP:0000001 "One of the two long bones of endochondral origin of the hind-epipodium; it is a straight, simple bone whose section is more or less rectangular at the ends and circular at its central portion.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000890", ontology="AAO", source="AAO:LAP"}
[Term]
@@ -165513,7 +165383,7 @@ relationship: connected_to UBERON:0002446 {gci_relation="part_of", gci_filler="N
relationship: develops_from UBERON:0010129 {evidence="definitional"} ! femur cartilage element
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: proximally_connected_to UBERON:0007832 ! pelvic girdle skeleton
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/73/Gray252.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/73/Gray252.png" xsd:anyURI
property_value: UBPROP:0000001 "Endochondral longbone connecting the pelvic girdle with posterior zeugopodium.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000186", ontology="VSAO", source="VSAO:NI"}
property_value: UBPROP:0000001 "Paired, elongate, cylindrical bones of endochondral origin that form the thighs, extending from the pelvic girdles to the knees.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000889", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001159", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"}
@@ -165616,7 +165486,7 @@ relationship: connected_to UBERON:0001587 ! subclavian vein
relationship: drains UBERON:0009472 ! axilla
relationship: part_of UBERON:0001467 ! shoulder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray576.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray576.png" xsd:anyURI
property_value: UBPROP:0000008 "In human anatomy, the axillary vein is a large blood vessel that conveys blood from the lateral aspect of the thorax, axilla (armpit) and upper limb toward the heart. There is one axillary vein on each side of the body. Its origin is at the lower margin of the teres major muscle and a continuation of the brachial vein. Its tributaries include the basilic vein and cephalic vein, which are both superficial veins. It terminates at the lateral margin of the first rib, at which it becomes the subclavian vein. It is accompanied along its course by a similarly named artery, the axillary artery" xsd:string {source="WP"}
[Term]
@@ -165664,7 +165534,7 @@ relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0001895 {source="neuronames"} ! metencephalon
relationship: part_of UBERON:0002298 ! brainstem
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png" xsd:anyURI
property_value: editor_note "The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved" xsd:string
property_value: RO:0002174 NCBITaxon:7955
property_value: UBPROP:0000001 "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pons"}
@@ -165705,7 +165575,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0008811 {source="Wikipedia"} ! intromittent organ
relationship: develops_from UBERON:0004876 {source="Wikipedia"} ! urogenital fold
relationship: develops_from UBERON:0005876 {source="EHDAA2"} ! undifferentiated genital tubercle
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/87/Labelled_flaccid_penis.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/87/Labelled_flaccid_penis.jpg" xsd:anyURI
property_value: UBPROP:0000007 "penile" xsd:string
property_value: UBPROP:0000007 "phallic" xsd:string
property_value: UBPROP:0000008 "Most male birds (e.g., roosters and turkeys) have a cloaca (also present on the female), but not a penis. Among bird species with a penis are paleognathes (tinamous and ratites), Anatidae (ducks, geese and swans), and a very few other species (such as flamingoes). A bird penis is different in structure from mammal penises, being an erectile expansion of the cloacal wall and being erected by lymph, not blood. It is usually partially feathered and in some species features spines and brush-like filaments, and in flaccid state curls up inside the cloaca" xsd:string {source="WP"}
@@ -165776,7 +165646,7 @@ relationship: capable_of_part_of GO:0000003 ! reproduction
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: has_part UBERON:0000991 ! gonad
property_value: dcterms-date "2022-06-10T18:22:34Z" xsd:dateTime
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg" xsd:anyURI
property_value: editor_note "consider splitting genitalia from reproductive system" xsd:string
property_value: UBPROP:0000001 "Anatomical system which consists of organs and tissues associated with sexual reproduction of the organism.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010258", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000182", ontology="VHOG", source="PMID:21672850 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across Bilateria. Integrative and Comparative Biology (2007)", source="http://bgee.unil.ch/"}
@@ -165895,8 +165765,8 @@ relationship: develops_from UBERON:0009117 ! indifferent gonad
relationship: in_lateral_side_of UBERON:0003975 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA-abduced-lr"} ! internal female genitalia
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: UBPROP:0000001 "Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000371", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "Female reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000403", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000251", ontology="VHOG", source="DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"}
@@ -165979,8 +165849,8 @@ relationship: immediate_transformation_of UBERON:0005795 ! embryonic uterus
relationship: only_in_taxon NCBITaxon:32525 ! Theria
relationship: part_of UBERON:0004175 ! internal genitalia
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Uterus.glb" xsd:string
property_value: UBPROP:0000001 "The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001137", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/uterus"}
property_value: UBPROP:0000003 "An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001137", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.678", source="http://bgee.unil.ch/"}
@@ -166021,8 +165891,8 @@ is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct
relationship: contributes_to_morphology_of UBERON:0003975 ! internal female genitalia
relationship: develops_from UBERON:0000164 {source="Wikipedia"} ! primitive urogenital sinus
relationship: part_of UBERON:0003975 {source="FMA"} ! internal female genitalia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Illu_repdt_female.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a4/Vaginal_opening_-_english_description.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Illu_repdt_female.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a4/Vaginal_opening_-_english_description.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Organ with organ cavity which connects the cervical canal of uterus to the vestibule of vagina.[FMA]" xsd:string {date_retrieved="2012-11-29", external_class="FMA:19949", ontology="FMA"}
property_value: UBPROP:0000001 "The genital canal in the female, leading from the opening of the vulva to the cervix of the uterus. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001138", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vagina"}
property_value: UBPROP:0000003 "The distal end of the oviducts differentiates as a vagina in Metatheria and Eutheria.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001138", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.688", source="http://bgee.unil.ch/"}
@@ -166066,7 +165936,7 @@ is_a: UBERON:0000062 ! organ
is_a: UBERON:0005156 ! reproductive structure
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of UBERON:0005056 ! external female genitalia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001458", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vulva"}
property_value: UBPROP:0000007 "vulval" xsd:string
@@ -166113,7 +165983,7 @@ relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genita
relationship: develops_from UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000473 ! testis
relationship: produces UBERON:0010143 ! seminal vesicle fluid
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb" xsd:string
property_value: UBPROP:0000001 "Either of a pair of pouchlike glands situated on each side of the male urinary bladder that secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001379", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/prominence"}
property_value: UBPROP:0000003 "(In mammalian testis) Along the way (the sperm travel), three accessory sex glands, the seminal vesicle, prostate, and bulbourethral (Cowper's) gland, respectively, add their secretions as sperm move from the testes to the urethra.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001379", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.556", source="http://bgee.unil.ch/"}
@@ -166154,7 +166024,7 @@ relationship: channels_from UBERON:0001000 ! vas deferens
relationship: channels_into UBERON:0000057 ! urethra
relationship: in_lateral_side_of UBERON:0000079 ! male reproductive system
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb" xsd:string
[Term]
@@ -166196,7 +166066,7 @@ relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genita
relationship: only_in_taxon NCBITaxon:32524 ! Amniota
relationship: part_of UBERON:0005352 {source="FMA"} ! spermatic cord
relationship: part_of UBERON:0006947 ! male genital duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI
property_value: UBPROP:0000003 "The continuation of the archinephric duct, now called the deferent duct, extends caudally to the cloaca or to the part of the mammalian urethra that is derived from the cloaca.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001135", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.670", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "Most vertebrates have some form of duct to transfer the sperm from the testes to the urethra. In cartilaginous fish and amphibians, sperm is carried through the archinephric duct, which also partially helps to transport urine from the kidneys. In teleosts, there is a distinct sperm duct, separate from the ureters, and often called the vas deferens, although probably not truly homologous with that in humans. In cartilaginous fishes, the part of the archinephric duct closest to the testis is coiled up to form an epididymis. Below this are a number of small glands secreting components of the seminal fluid. The final portion of the duct also receives ducts from the kidneys in most species. In amniotes, however, the archinephric duct has become a true vas deferens, and is used only for conducting sperm, never urine. As in cartilaginous fish, the upper part of the duct forms the epididymis. In many species, the vas deferens ends in a small sac for storing sperm. The only vertebrates to lack any structure resembling a vas deferens are the primitive jawless fishes, which release sperm directly into the body cavity, and then into the surrounding water through a simple opening in the body wall." xsd:string {source="WP"}
@@ -166309,7 +166179,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -166481,7 +166351,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073 ! Cnidaria
relationship: never_in_taxon NCBITaxon:6157 ! Platyhelminthes
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -166575,7 +166445,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -166638,8 +166508,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -166857,7 +166727,7 @@ is_a: UBERON:0015203 ! non-connected functional system
relationship: capable_of_part_of GO:0007600 ! sensory perception
relationship: overlaps UBERON:0001016 ! nervous system
relationship: part_of UBERON:0004456 ! entire sense organ system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string
@@ -166946,7 +166816,7 @@ relationship: has_part GO:0045095 ! keratin filament
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of UBERON:0001003 {source="FMA"} ! skin epidermis
relationship: part_of UBERON:0011932 {source="FMA"} ! pilosebaceous unit
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/25/Gray945.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/25/Gray945.png" xsd:anyURI
property_value: editor_note "TODO for now we treat vibrissa/whisker as a syonym, but these have different follicles. We could introduce subclasses (see also: Pangolin scales)" xsd:string
property_value: IAO:0000232 "this class defines an individual hair" xsd:string
@@ -166998,7 +166868,7 @@ is_a: UBERON:0005631 {seeAlso="https://github.com/obophenotype/uberon/issues/635
is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
relationship: has_developmental_contribution_from UBERON:0000925 {source="ISBN:0073040584"} ! endoderm
relationship: has_developmental_contribution_from UBERON:0004872 {source="ISBN:0073040584"} ! splanchnic layer of lateral plate mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png" xsd:anyURI
property_value: editor_note "consider splitting class" xsd:string
property_value: UBPROP:0000001 "One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000830", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/yolk+sac"}
property_value: UBPROP:0000001 "the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" xsd:string {source="MP:0001718"}
@@ -167032,7 +166902,7 @@ xref: VHOG:0000285
xref: Wikipedia:Foregut
xref: XAO:0000232
is_a: UBERON:0004921 ! subdivision of digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png" xsd:anyURI
property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure" xsd:string
property_value: UBPROP:0000001 "The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder." xsd:string {source="MP:0000474"}
property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000285", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
@@ -167130,7 +167000,7 @@ relationship: develops_from UBERON:0001041 ! foregut
relationship: distally_connected_to UBERON:0000945 {gci_relation="part_of", gci_filler="NCBITaxon:40674", notes="only in species that have a stomach"} ! stomach
relationship: part_of UBERON:0004908 ! upper digestive tract
relationship: proximally_connected_to UBERON:0001042 ! chordate pharynx
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000145", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000450", ontology="VHOG", source="DOI:10.1111/j.1096-3642.1996.tb01658.x Mallatt J, Ventilation and the origin of jawed vertebrates: a new mouth. Zoological Journal of the Linnean Society (1996)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "esophageal" xsd:string
@@ -167176,7 +167046,7 @@ relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system
relationship: located_in UBERON:0000167 ! oral cavity
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: produces UBERON:0001836 ! saliva
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/51/Illu_quiz_hn_02.jpg" xsd:anyURI
property_value: IAO:0000232 "currently we define saliva and salivary glands very generally in functional terms but it may be more appropriate to split this class. From WP: In most vertebrates, saliva does not contain any enzymes, consisting of mucus and water only, and its primary function is to moisten food while eating. As a result, true salivary glands are rarely found in fish or aquatic tetrapods, although there are often individual mucus-secreting cells. Amphibians have a single salivary gland, the intermaxillary gland, located in the forward part of the palate. Reptiles and birds normally have only very small glands on the lips, palate, and base of the mouth, although there are some birds with large glands, which produce a sticky saliva that helps in nest-building. The distinct parotid, submandibular, and sublingual glands are only developed in mammals." xsd:string {source="3"}
property_value: UBPROP:0000001 "A gland that produces the saliva. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-25, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000376", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "In air-feeding animals, the lack of water column to lubricate the food has been compensated for by the evolution of the salivary glands. These glands are present only in amniotes and are controlled by the parasympathetic system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000376", ontology="VHOG", source="ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptationm(2005) p.211", source="http://bgee.unil.ch/"}
@@ -167210,7 +167080,7 @@ xref: Wikipedia:Midgut
xref: XAO:0000103
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: proximally_connected_to UBERON:0001041 ! foregut
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. We may explicitly make this a developmental class" xsd:string
property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000290", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon" xsd:string {source="WP"}
@@ -167244,7 +167114,7 @@ xref: XAO:0000104
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0003104 {source="Wikipedia"} ! mesenchyme
relationship: proximally_connected_to UBERON:0001045 ! midgut
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png" xsd:anyURI
property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future (vertebrates have some contribution from NC - https://github.com/obophenotype/uberon/wiki/The-neural-crest). We may explicitly make this a developmental class" xsd:string
property_value: UBPROP:0000001 "the caudal portion of the primitive digestive tube of the embryo" xsd:string {source="MP:0008786"}
property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000459", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
@@ -167315,7 +167185,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -167363,7 +167233,7 @@ relationship: part_of UBERON:0000059 {source="MA"} ! large intestine
relationship: part_of UBERON:0006866 ! terminal part of digestive tract
relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
property_value: UBPROP:0000001 "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001751", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -167489,7 +167359,7 @@ relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla
relationship: continuous_with UBERON:0001174 ! common bile duct
relationship: develops_from UBERON:0003924 {source="EHDAA2"} ! ventral pancreatic bud
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI
property_value: editor_note "in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue" xsd:string
property_value: UBPROP:0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000256", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct." xsd:string {source="WP"}
@@ -167524,7 +167394,7 @@ is_a: UBERON:0011135 ! intervertebral cartilage
intersection_of: UBERON:0011135 ! intervertebral cartilage
intersection_of: has_part UBERON:0002242 ! nucleus pulposus
relationship: has_part UBERON:0002242 ! nucleus pulposus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray301.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray301.png" xsd:anyURI
property_value: UBPROP:0000008 "strictly speaking the term intervertebral disk [applies to intervertebral cartilage]" xsd:string
[Term]
@@ -167581,7 +167451,7 @@ relationship: branching_part_of UBERON:0001530 {source="FMA"} ! common carotid a
relationship: develops_from UBERON:0001530 {source="EHDAA2"} ! common carotid artery plus branches
relationship: part_of UBERON:0001530 {source="FMA"} ! common carotid artery plus branches
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif" xsd:anyURI
property_value: seeAlso "https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722" xsd:anyURI
property_value: UBPROP:0000008 "not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO" xsd:string
@@ -167646,7 +167516,7 @@ relationship: connected_to UBERON:0002078 ! right cardiac atrium
relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein
relationship: drains UBERON:0000154 ! posterior region of body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png" xsd:anyURI
property_value: UBPROP:0000001 "Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]." xsd:string {source="FMA:10951"}
property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001194", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"}
@@ -167742,7 +167612,7 @@ is_a: UBERON:0016491 ! vertebral centrum element
intersection_of: UBERON:0016491 ! vertebral centrum element
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
relationship: part_of UBERON:0002412 ! vertebra
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/63/Corpusvertebrae.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/63/Corpusvertebrae.png" xsd:anyURI
property_value: UBPROP:0000001 "Centra are represented by mineralized, calcified, or ossified portions that surround the notochord. The autocentrum, present in Danio and all other living teleosts, is formed by direct ossification outside the elastica externa of the notochord (Arratia, 1999).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000126", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Cylindrical body of bone, round or oval in cross section, which functionally replaces the notochord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000697", ontology="AAO", source="AAO:Duellman_and_Trueb_2008"}
property_value: UBPROP:0000001 "The body is the largest part of a vertebra, and is more or less cylindrical in shape. Its upper and lower surfaces are flattened and rough, and give attachment to the intervertebral fibrocartilages, and each presents a rim around its circumference. In front, the body is convex from side to side and concave from above downward. Behind, it is flat from above downward and slightly concave from side to side. Its anterior surface presents a few small apertures, for the passage of nutrient vessels. On the posterior surface is a single large, irregular aperture, or occasionally more than one, for the exit of the basi-vertebral veins from the body of the vertebra. [WP,unvetted][Wikipedia:Body_of_vertebra]." xsd:string {source="Wikipedia:Body_of_vertebra"}
@@ -167776,7 +167646,7 @@ xref: Wikipedia:Spinous_process
xref: ZFA:0001336
is_a: UBERON:0006061 ! process of vertebra
relationship: part_of UBERON:0003861 ! neural arch
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/48/Processusspinosusvertebrae.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/48/Processusspinosusvertebrae.png" xsd:anyURI
property_value: UBPROP:0000001 "Elaboration of the mid-dorsal keel into a posterior or posterolateral process.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000705", ontology="AAO", source="AAO:Pugener_and_Maglia_2008"}
property_value: UBPROP:0000001 "Neural spines are extensions of neural arches dorsal to the neural canal in the median skeletogenous septum. Neural spines are typically unpaired median structures but can be paired in some instances, e.g., in the abdominal region of basal teleosts such as Leptolepis, Elops, Megalops, and Hiodon).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001336", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Small, posteriorly directed process at the posterior margin of each neural arch lamina; it is not a neural spine.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000739", ontology="AAO", source="AAO:Pugener_2002"}
@@ -167803,7 +167673,7 @@ xref: SCTID:264238006
xref: Wikipedia:Transverse_process
xref: XAO:0003102
is_a: UBERON:0006061 ! process of vertebra
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Processustransversusvertebrae.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Processustransversusvertebrae.PNG" xsd:anyURI
property_value: UBPROP:0000001 "Projections on each side of the vertebra from the point where the neural arch lamina joins the pedicel for the articulation with the head of a single-headed rib or the upper head of a double-headed rib. Also called diapophyses. They provide surfaces for the attachment of muscles. In anurans, the term transverse process is used in reference to the processes associated with the presacral and postsacral vertebrae." xsd:string {source="AAO:0000698"}
[Term]
@@ -168077,7 +167947,7 @@ relationship: never_in_taxon NCBITaxon:8782 ! Aves
relationship: never_in_taxon NCBITaxon:9257 {source="PMID:10210685"}
relationship: never_in_taxon NCBITaxon:9761
relationship: part_of UBERON:0011595 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! jaw region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/14/Teeth_by_David_Shankbone.jpg" xsd:anyURI
property_value: editor_note "we place ZFA ctb 5 tooth here for now. Consider changing name from calcaeeous tooth. Note that sea cucumbers develop calcareous tooth-like structures" xsd:string
property_value: UBPROP:0000003 "The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001733", ontology="VHOG", source="PMID:19266065 Koussoulakou DS, Margaritis LH, Koussoulakos SL, A curriculum vitae of teeth: evolution, generation, regeneration. International Journal of Biological Sciences (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "dental" xsd:string
@@ -168256,7 +168126,7 @@ is_a: UBERON:0001495 {source="FMA"} ! pectoral muscle
relationship: has_muscle_insertion UBERON:0007174 {notes="medial border and superior surface of the coracoid process of the scapula", source="dbpedia"} ! medial border of scapula
relationship: has_muscle_origin UBERON:0002228 {notes="third to fifth ribs near their costal cartilages", source="dbpedia"} ! rib
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5d/Pectoralis_minor.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/5d/Pectoralis_minor.png" xsd:anyURI
[Term]
id: UBERON:0001103
@@ -168339,7 +168209,7 @@ relationship: has_developmental_contribution_from UBERON:0010843 {notes="from se
relationship: in_lateral_side_of UBERON:0002091 ! appendicular skeleton
relationship: overlaps UBERON:0001469 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! sternoclavicular joint
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg" xsd:anyURI
property_value: UBPROP:0000001 "Slender, paired bones of intramembranous origin that invest the anterior margins of the procoracoids.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000761", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: part_of zonal element (AAO:0000936)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000761", ontology="AAO"}
property_value: UBPROP:0000003 "In early tetrapods, the connecting skull bone, the posttemporal, and adjoining shoulder bones, supracleithrum and postcleithrum (=anocleithrum), are absent, leaving a dermal shoulder girdle composed of the remaining ventral elements: the paired cleithrum and clavicle, and an unpaired midventral interclavicle that joins both halves of the girdle across the midline. (...) Several dermal elements of the shoulder persist in early synapsids. The clavicle and interclavicle are present in therapsids and monotremes, but in marsupials and placentals, the interclavicle is absent, the clavicle often is reduced in size, and the scapula becomes the predominant shoulder element.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000849", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.330-333 and Figure 9.18", source="http://bgee.unil.ch/"}
@@ -168384,7 +168254,7 @@ relationship: has_muscle_origin UBERON:0006849 ! scapula
relationship: has_muscle_origin UBERON:0007175 {notes="spinous processes of thoracic T7-T12 thoracolumbar fascia iliac crest and inferior 3 or 4 ribs inferior angle of scapula", source="dbpedia"} ! inferior angle of scapula
relationship: part_of UBERON:0008713 {source="EHDAA2"} ! pectoral girdle and thoracic body wall skeletal muscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7d/Latissimus_dorsi.png" xsd:anyURI
property_value: UBPROP:0000008 "In humans it inserts along a roughened line deep in the groove. In other mammals (most, I believe) it is an actual projection, the latissimus dorsi process [FEED:rd] [https://github.com/obophenotype/uberon/issues/1192]" xsd:string
[Term]
@@ -168434,7 +168304,7 @@ xref: VHOG:0001424
xref: Wikipedia:Right_lobe_of_liver
xref: ZFA:0005173
is_a: UBERON:0001113 ! lobe of liver
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb" xsd:string
property_value: UBPROP:0000001 "Portion of the liver which develops on the fish's right side adjacent to the gall bladder.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005173", ontology="TAO", source="ZFIN:curator"}
@@ -168464,7 +168334,7 @@ xref: VHOG:0001423
xref: Wikipedia:Left_lobe_of_liver
xref: ZFA:0005172
is_a: UBERON:0001113 ! lobe of liver
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray1087-liver.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb" xsd:string
property_value: UBPROP:0000001 "Portion of the liver which develops on the fish's left side.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005172", ontology="TAO", source="ZFIN:curator"}
@@ -168495,7 +168365,7 @@ is_a: UBERON:0035075 ! thymus subunit
intersection_of: UBERON:0009912 ! anatomical lobe
intersection_of: part_of UBERON:0002046 ! thyroid gland
relationship: in_lateral_side_of UBERON:0002046 {source="FMA-abduced-lr"} ! thyroid gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI
property_value: UBPROP:0000003 "Thus, a thyroid capable of forming iodotyrosines and iodothyronines is present in all vertebrates. (...) Certain morphologic changes occur after the biochemical evolution of the thyroid has ceased. In the adult lamprey and in most bony fishes, the gland is not encapsulated. (...) In cartilaginous fish, the thyroid is encapsulated. In the higher vertebrate forms, the thyroid is a one- or two-lobed encapsulated structure.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000732", ontology="VHOG", source="http://bgee.unil.ch/", source="http://www.thyroidmanager.org/Chapter1/chapter01.htm"}
[Term]
@@ -168576,7 +168446,7 @@ relationship: has_muscle_insertion UBERON:0006849 {notes="costal aspect of media
relationship: has_muscle_origin UBERON:0002228 {notes="fleshy slips from the outer surface of upper 8 or 9 ribs", source="dbpedia"} ! rib
relationship: innervated_by UBERON:0003726 {notes="long thoracic nerve", source="dbpedia"} ! thoracic nerve
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c6/Serratus_anterior.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/c6/Serratus_anterior.png" xsd:anyURI
[Term]
id: UBERON:0001130
@@ -168654,7 +168524,7 @@ relationship: conduit_for UBERON:0002240 ! spinal cord
relationship: lumen_of UBERON:0010913 ! vertebral element
relationship: part_of UBERON:0006692 ! vertebral canal
relationship: part_of UBERON:0010913 ! vertebral element
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/10/Foramenvertebrale.png" xsd:anyURI
property_value: UBPROP:0000001 "Opening on the vertebra for a spinal nerve as it emerges from the spinal canal.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000729", ontology="AAO", source="AAO:LAP"}
[Term]
@@ -168781,7 +168651,7 @@ intersection_of: composed_primarily_of CL:0008002 ! skeletal muscle fiber
relationship: composed_primarily_of CL:0008002 ! skeletal muscle fiber
relationship: develops_from UBERON:0003082 ! myotome
relationship: part_of UBERON:0014892 ! skeletal muscle organ
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI
property_value: editor_note "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." xsd:string
property_value: UBPROP:0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005277", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" xsd:string {external_class="FMA:14069", ontology="FMA"}
@@ -168834,7 +168704,7 @@ disjoint_from: UBERON:0002036 ! striated muscle tissue
relationship: composed_primarily_of CL:0000192 ! smooth muscle cell
relationship: has_part CL:0000192 ! smooth muscle cell
relationship: has_part GO:0071953 ! elastic fiber
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI
property_value: UBPROP:0000001 "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005274", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010244", ontology="AAO", source="AAO:CAM"}
property_value: UBPROP:0000003 "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001246", ontology="VHOG", source="DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011)", source="http://bgee.unil.ch/"}
@@ -168870,7 +168740,7 @@ intersection_of: develops_from UBERON:0000926 ! mesoderm
intersection_of: part_of UBERON:0000042 ! serous membrane
relationship: composed_primarily_of CL:0000077 {source="FMA"} ! mesothelial cell
relationship: part_of UBERON:0000042 ! serous membrane
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI
[Term]
id: UBERON:0001137
@@ -168895,7 +168765,7 @@ xref: UMLS:C0004600 {source="ncithesaurus:Back"}
xref: Wikipedia:Dorsum_(anatomy)
is_a: UBERON:0000475 ! organism subdivision
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI
property_value: UBPROP:0000007 "dorsal" xsd:string
property_value: UBPROP:0000008 "In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body" xsd:string
@@ -168927,7 +168797,7 @@ relationship: develops_from UBERON:0005487 {source="Wikipedia:Vitelline_vein"} !
relationship: drains UBERON:0002108 ! small intestine
relationship: part_of UBERON:0005806 ! portal system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
[Term]
id: UBERON:0001139
@@ -168950,7 +168820,7 @@ is_a: UBERON:0005610 {source="MA"} ! iliac vein
is_a: UBERON:0015212 ! lateral structure
relationship: in_lateral_side_of UBERON:0001072 {source="FMA-abduced-lr"} ! posterior vena cava
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000008 "In human anatomy, the common iliac veins are formed by the external iliac veins and internal iliac veins and together, in the abdomen at the level of the fifth lumbar vertebrae, form the inferior vena cava. They drain blood from the pelvis and lower limbs. Both common iliac veins are accompanied along their course by common iliac arteries." xsd:string {source="Wikipedia:Common_iliac_vein"}
@@ -168986,7 +168856,7 @@ intersection_of: drains UBERON:0002113 ! kidney
relationship: drains UBERON:0002113 ! kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001072 ! posterior vena cava
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000001 "The renal veins are veins that drain the kidney. They connect the kidney to the inferior vena cava. It is usually singular to each kidney, except in the condition 'multiple renal veins'. It also divides into 2 divisions upon entering the kidney: the anterior branch which receives blood from the anterior portion of the kidney and, the posterior branch which receives blood from the posterior portion. Often, each renal vein will have a branch that receives blood from the ureter. [WP,unvetted][Wikipedia:Renal_vein]." xsd:string {source="Wikipedia:Renal_vein"}
@@ -169032,7 +168902,7 @@ intersection_of: UBERON:0001140 ! renal vein
intersection_of: drains UBERON:0004538 ! left kidney
relationship: drains UBERON:0004538 ! left kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000001 "A vein that drains blood from the left kidney into the inferior vena cava[ncithesaurus]." xsd:string {source="ncithesaurus:Left_Renal_Vein"}
@@ -169073,7 +168943,7 @@ relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="
relationship: drains UBERON:0002107 ! liver
relationship: part_of UBERON:0006877 ! vasculature of liver
relationship: tributary_of UBERON:0001072 {source="FMA-abduced-lr"} ! posterior vena cava
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png" xsd:anyURI
property_value: editor_note "todo - add developmental relationships for other taxa" xsd:string
[Term]
@@ -169109,7 +168979,7 @@ relationship: connected_to UBERON:0001330 ! pampiniform plexus
relationship: drains UBERON:0000473 ! testis
relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism
relationship: sexually_homologous_to UBERON:0001145 ! ovarian vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Gray590.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Gray590.png" xsd:anyURI
property_value: editor_note "TODO - check testicular vs spermatic vein (MA:0002218)" xsd:string
property_value: UBPROP:0000008 "In humans, the right testicular vein generally joins the inferior vena cava; the left testicular vein, unlike the right, often joins the left renal vein instead of the inferior vena cava. The veins emerge from the back of the testis, and receive tributaries from the epididymis; they unite and form a convoluted plexus, called the pampiniform plexus, which constitutes the greater mass of the spermatic cord; the vessels composing this plexus are very numerous, and ascend along the cord, in front of the ductus deferens. Below the subcutaneous inguinal ring, they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins, which ascend on the Psoas major, behind the peritoneum, lying one on either side of the internal spermatic artery. These unite to form a single vein, which opens, on the right side, into the inferior vena cava (at an acute angle), on the left side into the left renal vein (at a right angle). The spermatic veins are provided with valves. The left spermatic vein passes behind the iliac colon and is thus exposed to pressure from the contents of that part of the bowel" xsd:string
@@ -169144,7 +169014,7 @@ intersection_of: UBERON:0001638 ! vein
intersection_of: drains UBERON:0000992 ! ovary
relationship: drains UBERON:0000992 ! ovary
relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Ovarschaf.jpg" xsd:anyURI
[Term]
id: UBERON:0001146
@@ -169166,7 +169036,7 @@ is_a: UBERON:0001638 ! vein
intersection_of: UBERON:0001638 ! vein
intersection_of: drains UBERON:0002369 ! adrenal gland
relationship: drains UBERON:0002369 ! adrenal gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray1122.png" xsd:anyURI
[Term]
id: UBERON:0001152
@@ -169201,8 +169071,8 @@ relationship: channels_into UBERON:0001174 ! common bile duct
relationship: continuous_with UBERON:0001174 ! common bile duct
relationship: continuous_with UBERON:0002110 ! gallbladder
relationship: develops_from UBERON:0005604 {source="EHDAA2"} ! extrahepatic part of hepatic duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
property_value: UBPROP:0000001 "Duct that connects the gall bladder and the common bile duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005166", ontology="TAO", source="ZFIN:Curator"}
property_value: UBPROP:0000001 "The duct of the gallbladder which joins the common hepatic duct, thus forming the common biliary duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000213", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -169251,7 +169121,7 @@ relationship: never_in_taxon NCBITaxon:32443 {source="Wikipedia"} ! Teleostei
relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: part_of UBERON:0001155 {source="EHDAA2"} ! colon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
property_value: UBPROP:0000007 "caecal" xsd:string
@@ -169299,7 +169169,7 @@ relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
relationship: part_of UBERON:0000059 ! large intestine
relationship: present_in_taxon NCBITaxon:40674 ! Mammalia
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray536.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray536.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
property_value: UBPROP:0000001 "Organ with organ cavity which is continuous proximally with the cecum and distally terminates in the tip of the appendix. Examples: There is only one appendix[FMA:14542]." xsd:string {source="FMA:14542"}
@@ -169381,7 +169251,7 @@ is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001157 ! transverse colon
relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
property_value: UBPROP:0000012 "in MA, this is a subclass of colon" xsd:string {external_ontology="MA"}
@@ -169413,7 +169283,7 @@ is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001158 ! descending colon
relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
@@ -169444,7 +169314,7 @@ is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001159 ! sigmoid colon
relationship: develops_from UBERON:0001046 {source="Wikipedia"} ! hindgut
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray1223.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Gray1223.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
@@ -169479,7 +169349,7 @@ is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001052 ! rectum
relationship: develops_from UBERON:0001046 {source="Wikipedia"} ! hindgut
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Dickdarm-Schema.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:string
@@ -169517,7 +169387,7 @@ is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0009870 ! zone of stomach
relationship: contributes_to_morphology_of UBERON:0000945 ! stomach
relationship: has_part UBERON:0010038 ! fundic gastric gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
property_value: UBPROP:0000001 "The greater curvature of the stomach. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000421", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000421", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
@@ -169544,7 +169414,7 @@ xref: SCTID:362140009
xref: UMLS:C0227230 {source="ncithesaurus:Body_of_Stomach"}
xref: Wikipedia:Body_of_stomach
is_a: UBERON:0009870 {source="FMA"} ! zone of stomach
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
property_value: editor_note "we include this as zone of stomach even though it is not distinguished by gland type" xsd:string
[Term]
@@ -169583,7 +169453,7 @@ relationship: continuous_with UBERON:0001161 ! body of stomach
relationship: contributes_to_morphology_of UBERON:0000945 ! stomach
relationship: has_part UBERON:0008859 ! cardiac gastric gland
relationship: only_in_taxon NCBITaxon:40674 {source="ISBN:0073040584"} ! Mammalia
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg" xsd:anyURI
property_value: editor_note "There were previously conflicting statements in the academic anatomy community[10][11][12] over whether the cardia is part of the stomach, part of the esophagus or a distinct entity. Modern surgical and medical textbooks have agreed that 'The gastric cardia is now clearly considered to be part of the stomach'[13][14]. Classical anatomy textbooks, and some other resources[15], describe the cardia as the first of 4 regions of the stomach. This makes sense histologically because the mucosa of the cardia is the same as that of the stomach[WP]" xsd:string
property_value: editor_note "We follow Kardong in defining stomach regions by glands." xsd:string
@@ -169621,7 +169491,7 @@ relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus
relationship: has_part CL:0000502 ! type D enteroendocrine cell
relationship: has_part CL:0000508 ! type G enteroendocrine cell
relationship: part_of UBERON:0001166 {source="Wikipedia"} ! pylorus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
[Term]
id: UBERON:0001166
@@ -169660,7 +169530,7 @@ relationship: contributes_to_morphology_of UBERON:0000945 ! stomach
relationship: has_part UBERON:0001165 ! pyloric antrum
relationship: has_part UBERON:0008858 ! pyloric canal
relationship: has_part UBERON:0008861 ! pyloric gastric gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray1046.svg" xsd:anyURI
property_value: editor_note "We follow Kardong in defining stomach regions by glands" xsd:string
property_value: UBPROP:0000001 "The orifice which allows the passage from the stomach into the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000420", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000420", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
@@ -169847,7 +169717,7 @@ relationship: channels_into UBERON:0001064 ! ventral pancreatic duct
relationship: continuous_with UBERON:0001152 ! cystic duct
relationship: continuous_with UBERON:0001175 ! common hepatic duct
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
property_value: UBPROP:0000001 "Digestive system duct that collects bile from the hepatic bile duct and the cystic duct.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005165", ontology="TAO", source="ZFIN:Curator"}
property_value: UBPROP:0000001 "The duct formed by the union of the common hepatic and cystic ducts. [Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, adapted_from_Dorian_AF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000214", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -169876,7 +169746,7 @@ relationship: continuous_with UBERON:0001176 {source="Wikipedia"} ! right hepati
relationship: continuous_with UBERON:0001177 {source="Wikipedia"} ! left hepatic duct
relationship: immediate_transformation_of UBERON:0010081 {evidence="definitional"} ! future common hepatic duct
relationship: part_of UBERON:0005604 {source="MA"} ! extrahepatic part of hepatic duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/48/Illu_liver_gallbladder.jpg" xsd:anyURI
property_value: editor_note "TODO - MA distinguishes between bile duct, hepatic duct, common bile duct and common hepatic duct. in FMA hepatic duct and common hepatic duct are the same. Common is part of extra-hepatic part" xsd:string
property_value: UBPROP:0000001 "The duct which conveys the bile from the liver and unites with the cystic duct to form the common bile duct. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000220", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -169943,7 +169813,7 @@ is_a: UBERON:0022350 ! visceral serous membrane
intersection_of: UBERON:0022350 ! visceral serous membrane
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0002358 ! peritoneum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI
[Term]
id: UBERON:0001179
@@ -170011,8 +169881,8 @@ intersection_of: supplies UBERON:0002116 ! ileum
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002115 ! jejunum
relationship: supplies UBERON:0002116 ! ileum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray1099.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Superior_mesenteric_a.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray1099.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Superior_mesenteric_a.gif" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000010 "Origin: abdominal aorta; branches, inferior pancreaticoduodenal, jejunal, ileal, ileocolic, right colic, and middle colic arteries; distribution: small intestine, proximal half of colon" xsd:string {source="BTO"}
@@ -170051,7 +169921,7 @@ intersection_of: supplies UBERON:0001159 ! sigmoid colon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001158 ! descending colon
relationship: supplies UBERON:0001159 ! sigmoid colon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e4/Gray538.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e4/Gray538.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -170092,7 +169962,7 @@ intersection_of: UBERON:0001637 ! artery
intersection_of: supplies UBERON:0002113 ! kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002113 ! kidney
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI
property_value: editor_note "renal arteries vary widely even in humans. Sub-structures should be checked for taxon variability." xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -170120,7 +169990,7 @@ intersection_of: UBERON:0001184 ! renal artery
intersection_of: supplies UBERON:0004539 ! right kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0004539 ! right kidney
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -170174,7 +170044,7 @@ intersection_of: UBERON:0001637 ! artery
intersection_of: supplies UBERON:0000473 ! testis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0000473 ! testis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI
[Term]
id: UBERON:0001188
@@ -170240,7 +170110,7 @@ intersection_of: supplies UBERON:0000992 ! ovary
relationship: connected_to UBERON:0001516 ! abdominal aorta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0000992 ! ovary
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ae/Gray1170.png" xsd:anyURI
property_value: UBPROP:0000001 "In human anatomy, the ovarian artery is a blood vessel that supplies oxygenated blood to the ovary. It arises from the abdominal aorta below the renal artery, and does not pass out of the abdomiproperty_value external_definitioncavity. It can be found in the suspensory ligament of the ovary. [WP]." xsd:string {source="Wikipedia:Ovarian_artery"}
[Term]
@@ -170267,7 +170137,7 @@ is_a: UBERON:0012254 ! abdominal aorta artery
relationship: develops_from UBERON:0005458 {gci_relation="part_of", gci_filler="NCBITaxon:9606", notes="requires review", source="EHDAA2"} ! left umbilical artery
relationship: develops_from UBERON:0005470 {gci_relation="part_of", gci_filler="NCBITaxon:9606", notes="requires review", source="EHDAA2"} ! right umbilical artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Iliac_artery_bifurcation_and_aorta.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Iliac_artery_bifurcation_and_aorta.PNG" xsd:anyURI
[Term]
id: UBERON:0001193
@@ -170296,7 +170166,7 @@ intersection_of: UBERON:0001637 ! artery
intersection_of: supplies UBERON:0002107 ! liver
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002107 ! liver
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Common_and_proper_hepatic_artery.png" xsd:anyURI
property_value: IAO:0000232 "currently defined in a generic fashion." xsd:string
property_value: UBPROP:0000001 "Artery that supplies blood to the liver.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005161", ontology="TAO", source="ZFIN:curator"}
@@ -170328,7 +170198,7 @@ disjoint_from: UBERON:0001640 ! celiac artery
relationship: branching_part_of UBERON:0001640 ! celiac artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002106 ! spleen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a2/Gray1188.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/268" xsd:anyURI
@@ -170356,7 +170226,7 @@ intersection_of: supplies UBERON:0001157 ! transverse colon
relationship: branching_part_of UBERON:0001182 ! superior mesenteric artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001157 ! transverse colon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray537.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray537.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -170387,7 +170257,7 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001153 ! caecum
relationship: supplies UBERON:0001154 ! vermiform appendix
relationship: supplies UBERON:0002116 ! ileum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray536.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray536.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -170437,7 +170307,7 @@ intersection_of: part_of UBERON:0000945 ! stomach
relationship: capable_of GO:0001696 ! gastric acid secretion
relationship: contributes_to_morphology_of UBERON:0001167 ! wall of stomach
relationship: part_of UBERON:0001167 ! wall of stomach
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/1/1c/Normal_gastric_mucosa_intermed_mag.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The gastric mucosa is the mucous membrane layer of the stomach which contains the glands and the gastric pits. In men it is about 1 mm thick and its surface is smooth, soft, and velvety. It consists of epithelium, lamina propria, and the muscularis mucosae. In its fresh state, it is of a pinkish tinge at the pyloric end and of a red or reddish-brown color over the rest of its surface. In infancy it is of a brighter hue, the vascular redness being more marked. It is thin at the cardiac extremity, but thicker toward the pylorus. During the contracted state of the organ it is thrown into numerous plaits or rugae, which, for the most part, have a longitudinal direction, and are most marked toward the pyloric end of the stomach, and along the greater curvature. These folds are entirely obliterated when the organ becomes distended. When examined with a lens, the inner surface of the mucous membrane presents a peculiar honeycomb appearance from being covered with funnel-like depressions or foveolae of a polygonal or hexagonal form, which vary from 0.12 to 0.25 mm. in diameter. These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. There are three types of glands: cardiac glands (in the proximal part of the stomach), oxyntic glands (the dominating type of gland), and pyloric glands. The cardiac glands mainly contain mucus producing cells. The bottom part of the oxyntic glands is dominated by zymogen (chief) cells that produce pepsinogen (an inactive precursor of the pepsin enzyme). Parietal cells, which secrete hydrochloric acid are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells. Several types of endocrine cells are found in all regions of the gastric mucosa. In the pyloric glands contain gastrin producing cells (G cells); this hormone stimulates acid production from the parietal cells. ECL (enterochromaffine-like) cells, found in the oxyntic glands release histamine, which also is a powerful stimulant of the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells that produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium . This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general lining of the stomach. [WP,unvetted][Wikipedia:Gastric_mucosa]." xsd:string {source="Wikipedia:Gastric_mucosa"}
[Term]
@@ -170815,7 +170685,7 @@ relationship: has_part UBERON:0001981 ! blood vessel
relationship: has_part UBERON:0012425 ! striated border microvillus layer
relationship: part_of UBERON:0001204 {gci_relation="part_of", gci_filler="NCBITaxon:9606", notes="may be present in other parts in other species", source="FMA"} ! mucosa of small intestine
relationship: part_of UBERON:0001277 {source="ZFA"} ! intestinal epithelium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg" xsd:anyURI
property_value: editor_note "in mammals, villi are (largely?) absent from the large intestine, so we treat this as equivalent to small intestinal villus. small/large subdivision may not make sense for all species for which this is present (see ZFA). Note that VHOG quotes ISBN:978-0030223693 as suggesting there are some villi in the large intestine" xsd:string
property_value: UBPROP:0000001 "The entire digestive tract is lined by well developed villi, which are longest in the intestinal bulb and decrease progressively in size towards the caudal end of the intestine. No crypts are present, but, the regions between the villi, the intervillus pockets, have a crypt-like function. Cells are produced in the intervillus pockets and shed from the villus tips. Crosnier et al. 2005[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005125", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000012 "the BTO class refers to a generic villous" xsd:string {external_ontology="BTO"}
@@ -170846,7 +170716,7 @@ intersection_of: drains UBERON:0000059 ! large intestine
relationship: drains UBERON:0000059 ! large intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0003713 {source="FMA/obol"} ! splenic vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
[Term]
@@ -170866,7 +170736,7 @@ intersection_of: drains UBERON:0002115 ! jejunum
relationship: drains UBERON:0002115 ! jejunum
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001138 {source="FMA/obol"} ! superior mesenteric vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
[Term]
id: UBERON:0001217
@@ -170909,7 +170779,7 @@ intersection_of: tributary_of UBERON:0001138 ! superior mesenteric vein
relationship: drains UBERON:0001157 ! transverse colon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001138 ! superior mesenteric vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -170937,7 +170807,7 @@ intersection_of: tributary_of UBERON:0001138 ! superior mesenteric vein
relationship: drains UBERON:0001153 ! caecum
relationship: drains UBERON:0001155 ! colon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -171014,7 +170884,7 @@ relationship: contributes_to_morphology_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0002113 {source="MA"} ! kidney
relationship: part_of UBERON:0036295 ! renal pelvis/ureter
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Illu_kidney2.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Illu_kidney2.jpg" xsd:anyURI
[Term]
id: UBERON:0001225
@@ -171045,7 +170915,7 @@ intersection_of: part_of UBERON:0002113 ! kidney
relationship: contributes_to_morphology_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0008987 {source="FMA"} ! renal parenchyma
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb" xsd:string
@@ -171076,7 +170946,7 @@ relationship: contributes_to_morphology_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001294 ! inner medulla of kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Ureter_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Ureter_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb" xsd:string
@@ -171118,7 +170988,7 @@ relationship: contributes_to_morphology_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001285 {source="MA", source="ZFA"} ! nephron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/22/Renal_corpuscle.svg" xsd:anyURI
property_value: UBPROP:0000001 "A mass of arterial capillaries enveloped in a capsule and attached to a tubule in the kidney[BTO]" xsd:string {date_retrieved="2012-11-28", external_class="BTO:0000333", ontology="BTO", source="BTO:curator"}
property_value: UBPROP:0000001 "A tuft of capillaries found in a Bowman's capsule in which waste products are filtered from the blood and urine formation is initiated. Paired highly vascularized structures of the pronephros, responsible for blood filtration.[XAO]" xsd:string {date_retrieved="2012-11-28", external_class="XAO:0000146", ontology="XAO", source="XAO:curator"}
property_value: UBPROP:0000001 "The part of the nephron that filters blood.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005281", ontology="TAO", source="ZFIN:curator"}
@@ -171163,7 +171033,7 @@ relationship: capable_of_part_of GO:0003094 {source="Wikipedia"} ! glomerular fi
relationship: contributes_to_morphology_of UBERON:0001229 ! renal corpuscle
relationship: develops_from UBERON:0004199 ! S-shaped body
relationship: part_of UBERON:0001229 ! renal corpuscle
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1130.svg" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical structure found in the kidney consisting of an expanded end of a kidney tubule surrounding a glomerulus and is the major site of filtration.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010526", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000009 "Fluids from blood in the glomerulus are collected in the Bowman's capsule and further processed along the nephron to form urine. This process is known as ultrafiltration[WP]." xsd:string
property_value: UBPROP:0000011 "One fold of the S-shaped body gives rise to Bowman's capsule[GUDMAP]" xsd:string
@@ -171329,7 +171199,7 @@ relationship: capable_of GO:0006705 ! mineralocorticoid biosynthetic process
relationship: capable_of GO:0035932 ! aldosterone secretion
relationship: contributes_to_morphology_of UBERON:0002369 ! adrenal gland
relationship: part_of UBERON:0002369 ! adrenal gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI
property_value: UBPROP:0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001481", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "Kardong states that mammals are the first to have distinct cortext and medulla, but this contradicts XAO" xsd:string
@@ -171376,7 +171246,7 @@ relationship: has_part CL:0002082 {source="FMA"} ! type II cell of adrenal medul
relationship: has_part CL:0002083 {source="FMA"} ! type I cell of adrenal medulla
relationship: part_of UBERON:0002369 ! adrenal gland
relationship: surrounded_by UBERON:0001235 {source="Wikipedia"} ! adrenal cortex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI
property_value: UBPROP:0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues (medulla), but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001378", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", source="http://bgee.unil.ch/"}
[Term]
@@ -171401,7 +171271,7 @@ xref: SCTID:276159005
xref: UMLS:C0442134 {source="ncithesaurus:Paraaortic"}
xref: Wikipedia:Organ_of_Zuckerkandl
is_a: UBERON:0012279 ! chromaffin paraganglion
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI
[Term]
id: UBERON:0001238
@@ -171588,8 +171458,8 @@ relationship: develops_from UBERON:0000931 ! proctodeum
relationship: distalmost_part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/65/Protovsdeuterostomes.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI
property_value: UBPROP:0000007 "anal" xsd:string
property_value: UBPROP:0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" xsd:string
@@ -171699,7 +171569,7 @@ relationship: composed_primarily_of CL:0000542 ! lymphocyte
relationship: contributes_to_morphology_of UBERON:0002106 ! spleen
relationship: present_in_taxon NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"}
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI
[Term]
id: UBERON:0001251
@@ -171723,7 +171593,7 @@ relationship: adjacent_to UBERON:0001250 ! red pulp of spleen
relationship: adjacent_to UBERON:0001959 ! white pulp of spleen
relationship: part_of UBERON:0002106 ! spleen
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI
property_value: UBPROP:0000012 "WP says - (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) - we use the adjacency relation here so it overlaps neither. FMA considers this an anatomical line." xsd:string {external_ontology="FMA"}
[Term]
@@ -171832,7 +171702,7 @@ relationship: develops_from UBERON:0000164 {notes="upper part of UG sinus"} ! pr
relationship: never_in_taxon NCBITaxon:8782 {editor="https://orcid.org/0000-0003-3308-6245", id="GOTAX:0010073", source="https://github.com/obophenotype/uberon/issues/454"} ! Aves
relationship: part_of UBERON:0001556 {source="FMA"} ! lower urinary tract
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Urinary_Bladder.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urinary_Bladder.glb" xsd:string
property_value: UBPROP:0000001 "A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000740", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -171898,7 +171768,7 @@ is_a: UBERON:0000064 ! organ part
relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0006082 ! fundus of urinary bladder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/57/Illu_bladder.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Urinary_Bladder.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urinary_Bladder.glb" xsd:string
property_value: UBPROP:0000009 "The area is very sensitive to expansion and once stretched to a certain degree, the urinary bladder signals the brain of its need to empty. The signals become stronger as the bladder continues to fill." xsd:string
@@ -171931,7 +171801,7 @@ intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/63/Gray1156.png" xsd:anyURI
[Term]
id: UBERON:0001259
@@ -172117,7 +171987,7 @@ relationship: has_part UBERON:0000016 ! endocrine pancreas
relationship: has_part UBERON:0000017 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! exocrine pancreas
relationship: only_in_taxon NCBITaxon:7742 {source="PMID:16417468"} ! Vertebrata
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Blausen_0699_PancreasAnatomy2.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pancreas.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pancreas.glb" xsd:string
property_value: UBPROP:0000001 "Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010112", ontology="AAO", source="AAO:BJB"}
@@ -172241,7 +172111,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: in_lateral_side_of UBERON:0007832 ! pelvic girdle skeleton
relationship: part_of UBERON:0001464 {source="FMA"} ! hip
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray341.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray341.png" xsd:anyURI
property_value: editor_note "currently this class is restricted to exclude the teleost bone as the definition mentions ilium, ischium and pubis. In future we may add a grouping class for girdle bones that supports the appendage" xsd:string
property_value: UBPROP:0000008 "The hip/pelvic bone/basipterygium first appears in fishes, where it consists of a simple, usually triangular bone, to which the pelvic fin articulates. The hip bones on each side usually connect with each other at the forward end, and are even solidly fused in lungfishes and sharks, but they never attach to the vertebral column" xsd:string {source="WP"}
property_value: UBPROP:0000012 "in FMA this is a paired structure. NCITA has 'pelvic bone' but this is the *superclass* of ilium/ischium/pubis. The MA class 'pelvis bone' is actually a superclass of 'pelvic girdle bone' and caudal/sacral vertebra." xsd:string {external_ontology="FMA"}
@@ -172325,7 +172195,7 @@ relationship: contributes_to_morphology_of UBERON:0007830 ! pelvic girdle bone/z
relationship: develops_from UBERON:0006254 {source="cjm"} ! ischial cartilage element
relationship: in_lateral_side_of UBERON:0007832 ! pelvic girdle skeleton
relationship: part_of UBERON:0001272 ! innominate bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Illu_pelvic_girdle.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Illu_pelvic_girdle.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pelvis.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pelvis.glb" xsd:string
property_value: UBPROP:0000001 "Paired bones of endochondral origin that constitute the posterior elements of the pelvic girdle. They are synostotically fused to each other and form the posterior part of the acetabulum.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000860", ontology="AAO", source="AAO:LAP"}
@@ -172443,7 +172313,7 @@ relationship: has_part UBERON:0002017 ! portal vein
relationship: has_part UBERON:0003704 ! intrahepatic bile duct
relationship: part_of UBERON:0001172 ! hepatic acinus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/62/Portal_triad.JPG" xsd:anyURI
property_value: UBPROP:0000013 "The misnomer 'portal triad' traditionally has included only the first three structures, and was named before lymphatic vessels were discovered in the structure. It can refer both to the largest branch of each of these vessels running inside the hepatoduodenal ligament, and to the smaller branches of these vessels inside the liver." xsd:string
[Term]
@@ -172583,7 +172453,7 @@ relationship: develops_from UBERON:0004208 {evidence="definitional"} ! nephrogen
relationship: immediate_transformation_of UBERON:0010532 {source="Bgee:AN"} ! primitive nephron
relationship: part_of UBERON:0007684 {source="FMA"} ! uriniferous tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
property_value: editor_note "kidney terms require review for cross-vertebrate compatibility and developmental relationships." xsd:string
property_value: UBPROP:0000001 "Functional unit of the kidney that filters waste.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002153", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000008 "In the avian kidney, three types of nephron are identified: mammalian-type nephrons with long and short loops of Henle, and reptilian type nephrons (Gambaryan, 1992)" xsd:string {source="GO"}
@@ -172660,7 +172530,7 @@ relationship: continuous_with UBERON:0001290 ! proximal straight tubule
relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule
relationship: develops_from UBERON:0003220 {source="Wikipedia"} ! metanephric mesenchyme
relationship: part_of UBERON:0004134 {notes="MA uses subclass", source="GOC:mtg_kidney_jan10"} ! proximal tubule
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
property_value: UBPROP:0000001 "Renal tubule that connects to the renal corpuscle.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005290", ontology="TAO", source="ZFIN:curator"}
[Term]
@@ -172693,7 +172563,7 @@ relationship: continuous_with UBERON:0001287 ! proximal convoluted tubule
relationship: continuous_with UBERON:0001292 ! distal convoluted tubule
relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule
relationship: present_in_taxon NCBITaxon:8782 ! Aves
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
property_value: editor_note "the definitions of some kidney parts (e.g. proximal straight tubule) refer to Henle's loop, even in species where this may not be present. Requires review." xsd:string
property_value: RO:0002174 NCBITaxon:8353
property_value: UBPROP:0000001 "A highly specialized segment of the mammalian kidney tubules, that dips into the medulla. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.648, see_Liem_KF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001270", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -172722,7 +172592,7 @@ is_a: UBERON:0007685 {source="FMA"} ! region of nephron tubule
relationship: contributes_to_morphology_of UBERON:0001288 ! loop of Henle
relationship: part_of UBERON:0001288 {source="FMA"} ! loop of Henle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0001290
@@ -172788,7 +172658,7 @@ is_a: UBERON:0009035 {source="MA"} ! renal straight tubule
relationship: contributes_to_morphology_of UBERON:0005164 ! ascending limb of loop of Henle
relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
property_value: editor_note "TODO - thick/thin check. Also - does the loop of Henle overlap the distal convoluted tubule? FMA divides DCT into straight and convoluted portions" xsd:string
[Term]
@@ -172819,7 +172689,7 @@ relationship: contributes_to_morphology_of UBERON:0001231 ! nephron tubule
relationship: develops_from UBERON:0003220 ! metanephric mesenchyme
relationship: part_of UBERON:0004135 {source="EMAPA", source="GO", source="MA-modified-from-isa"} ! distal tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png" xsd:anyURI
property_value: UBPROP:0000001 "a portion of kidney nephron between the loop of Henle and the collecting duct system[Wikipedia:Distal_convoluted_tubule]." xsd:string {source="Wikipedia:Distal_convoluted_tubule"}
property_value: UBPROP:0000009 "in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." xsd:string
@@ -172910,7 +172780,7 @@ relationship: contributes_to_morphology_of UBERON:0000995 ! uterus
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of UBERON:0000459 {source="FMA"} ! uterine wall
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The mucous membrane lining the uterus. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001285", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Endometrium"}
property_value: UBPROP:0000003 "The maternal part of the placenta (of eutherian mammals) is the vascularized and glandular uterine lining, or endometrium.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001285", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endometrial" xsd:string
@@ -172949,7 +172819,7 @@ relationship: contributes_to_morphology_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000459 {source="FMA"} ! uterine wall
relationship: surrounded_by UBERON:0001297 ! serosa of uterus
relationship: surrounds UBERON:0001295 ! endometrium
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The muscular wall of the uterus. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001281", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/myometrium"}
property_value: UBPROP:0000003 "In all mammals, the uterus develops as a specialization of the paramesonephric or Müllerian ducts, which gives rise to the infundibula, oviducts, uterus, cervix, and anterior vagina. Morphogenetic events common to development of all uteri include: 1) differentiation and growth of the myometrium, 2) differentiation and morphogenesis of the endometrial glands, and 3) organization and stratification of endometrial stroma. Uterine development is initiated in the fetus, but is only completed postnatally with differentiation and development of the endometrial glands.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001281", ontology="VHOG", source="PMID:15471813 Spencer TE, Bazer FW, Uterine and placental factors regulating conceptus growth in domestic animals. Journal of Animal Science (2004)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "myometrial" xsd:string
@@ -172981,7 +172851,7 @@ is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000459 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! uterine wall
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
property_value: editor_note "TODO - check for parallel structure with peritoneum" xsd:string
[Term]
@@ -173012,8 +172882,8 @@ relationship: contributes_to_morphology_of UBERON:0000989 ! penis
relationship: immediate_transformation_of UBERON:0013239 {source="Bgee:AN"} ! future glans penis
relationship: part_of UBERON:0000989 ! penis
relationship: sexually_homologous_to UBERON:0006653 ! glans clitoris
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/13/Anteriorglanspenis.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/13/Anteriorglanspenis.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI
[Term]
id: UBERON:0001301
@@ -173050,7 +172920,7 @@ relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genita
relationship: develops_from UBERON:0003074 {source="Wikipedia"} ! mesonephric duct
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0006947 {source="FMA"} ! male genital duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_testis_surface.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_testis_surface.jpg" xsd:anyURI
property_value: editor_note "Kardong has epididymis in elasmobranch" xsd:string
property_value: UBPROP:0000007 "epididymal" xsd:string
property_value: UBPROP:0000008 "A similar, but probably non-homologous, structure is found in cartilaginous fishes" xsd:string {source="WP"}
@@ -173164,8 +173034,8 @@ relationship: has_part CL:0000023 ! oocyte
relationship: has_part CL:0002174 ! follicular cell of ovary
relationship: has_part UBERON:0000038 ! follicular fluid
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Human_ovarian_follicle.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Human_ovarian_follicle.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/e/e6/Primary_follicle-4.JPG" xsd:anyURI
property_value: editor_note "TODO - align subtypes based on staging, which is taxon-specific" xsd:string
property_value: UBPROP:0000001 "Oocyte development of zebrafish has been divided into five stages based on morphological criteria and on physiological and biochemical events. Stage I follicles (less than 140 microns) are primary growth stage, stage II follicles (140-340 microns) are cortical alveolus stage, stage III (340-690 microns) are vitellogenesis, stage IV (690-730 microns) are oocyte maturation, and stage V follicles are matured egg. Selman et al, 1993.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001110", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001536", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T, Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"}
@@ -173214,7 +173084,7 @@ xref: Wikipedia:External_iliac_artery
is_a: UBERON:0005609 {source="MA"} ! iliac artery
relationship: part_of UBERON:0001191 ! common iliac artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray539.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3e/Gray539.png" xsd:anyURI
[Term]
id: UBERON:0001309
@@ -173237,7 +173107,7 @@ xref: Wikipedia:Internal_iliac_artery
is_a: UBERON:0005609 {source="MA"} ! iliac artery
relationship: part_of UBERON:0001191 ! common iliac artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d3/Iliac_artery_bifurcation.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d3/Iliac_artery_bifurcation.PNG" xsd:anyURI
[Term]
id: UBERON:0001310
@@ -173266,7 +173136,7 @@ xref: Wikipedia:Umbilical_artery
is_a: UBERON:0001637 ! artery
is_a: UBERON:0010260 ! umbilical blood vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png" xsd:anyURI
property_value: editor_note "todo - compare with EHDAA2. Check embryonic vs extraembryonic, developmental relationships" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb" xsd:string
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/328" xsd:anyURI
@@ -173298,7 +173168,7 @@ relationship: supplies UBERON:0000998 {gci_filler="UBERON:0003101", gci_relation
relationship: supplies UBERON:0001000 {gci_filler="UBERON:0003101", gci_relation="part_of"} ! vas deferens
relationship: supplies UBERON:0002367 {gci_filler="UBERON:0003101", gci_relation="part_of"} ! prostate gland
relationship: supplies UBERON:0006082 ! fundus of urinary bladder
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/1/13/Inferiorvesical.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/1/13/Inferiorvesical.png" xsd:anyURI
[Term]
id: UBERON:0001312
@@ -173322,7 +173192,7 @@ is_a: UBERON:0009027 ! vesical artery
intersection_of: UBERON:0009027 ! vesical artery
intersection_of: supplies UBERON:0000056 ! ureter
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/02/Internal_iliac_branches.PNG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/0/02/Internal_iliac_branches.PNG" xsd:anyURI
property_value: UBPROP:0000011 "The first part of the superior vesical artery represents the terminal section of the previous portion of the umbilical artery (fetal hypogastric artery)[WP]" xsd:string
[Term]
@@ -173346,7 +173216,7 @@ is_a: UBERON:0005610 {source="MA"} ! iliac vein
relationship: connected_to UBERON:0001139 ! common iliac vein
relationship: drains UBERON:0002103 ! hindlimb
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/65/Iliac_veins.gif" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
[Term]
@@ -173374,7 +173244,7 @@ is_a: UBERON:0005610 {source="MA"} ! iliac vein
relationship: connected_to UBERON:0001139 ! common iliac vein
relationship: drains UBERON:0005179 ! pelvic region element
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Internaliliacv.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Internaliliacv.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -173413,7 +173283,7 @@ intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001317 {source="FMA/obol"} ! internal iliac vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
[Term]
id: UBERON:0001322
@@ -173449,7 +173319,7 @@ relationship: innervates UBERON:0001511 ! skin of leg
relationship: overlaps UBERON:0000978 ! leg
relationship: part_of UBERON:0001815 ! lumbosacral nerve plexus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray1244.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray1244.png" xsd:anyURI
property_value: UBPROP:0000008 "mouse sciatic nerve origins predominantly from the third lumbar (L3) and L4 spinal nerves, unlike the L4 and L5 in rats - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700063/" xsd:string
[Term]
@@ -173471,7 +173341,7 @@ xref: UMLS:C0040186 {source="ncithesaurus:Tibial_Nerve"}
xref: Wikipedia:Tibial_nerve
is_a: UBERON:0003431 ! leg nerve
relationship: branching_part_of UBERON:0001322 {source="FMA", source="WP"} ! sciatic nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1a/Gray828.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1a/Gray828.png" xsd:anyURI
[Term]
id: UBERON:0001325
@@ -173536,7 +173406,7 @@ is_a: UBERON:0001593 ! venous plexus
relationship: connected_to UBERON:0000442 ! right testicular vein
relationship: located_in UBERON:0005352 ! spermatic cord
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray1147.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray1147.png" xsd:anyURI
[Term]
id: UBERON:0001331
@@ -173591,8 +173461,8 @@ intersection_of: part_of UBERON:0000989 ! penis
relationship: adjacent_to UBERON:0001299 ! glans penis
relationship: part_of UBERON:0000989 ! penis
relationship: transformation_of UBERON:0035005 ! preputial swelling of male
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/c/cc/Foreskin2.jpg/200px-Foreskin2.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/e/e6/Foreskin_CloseupV2.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/c/cc/Foreskin2.jpg/200px-Foreskin2.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/e/e6/Foreskin_CloseupV2.jpg" xsd:anyURI
[Term]
id: UBERON:0001333
@@ -173613,7 +173483,7 @@ is_a: UBERON:0000057 ! urethra
intersection_of: UBERON:0000057 ! urethra
intersection_of: part_of UBERON:0003101 ! male organism
relationship: part_of UBERON:0003101 ! male organism
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urethra.glb" xsd:string
[Term]
@@ -173637,7 +173507,7 @@ is_a: UBERON:0000057 ! urethra
intersection_of: UBERON:0000057 ! urethra
intersection_of: part_of UBERON:0003100 ! female organism
relationship: part_of UBERON:0003100 ! female organism
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
[Term]
id: UBERON:0001335
@@ -173665,7 +173535,7 @@ relationship: contributes_to_morphology_of UBERON:0001333 ! male urethra
relationship: located_in UBERON:0002367 {source="FMA"} ! prostate gland
relationship: part_of UBERON:0001333 {source="FMA", source="MA"} ! male urethra
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray1142.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray1142.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urethra.glb" xsd:string
[Term]
@@ -173733,8 +173603,8 @@ relationship: channels_into UBERON:0003959 {gci_relation="part_of", gci_filler="
relationship: contains_process GO:0007283 ! spermatogenesis
relationship: develops_from UBERON:0005297 {source="Wikipedia"} ! testis sex cord
relationship: part_of UBERON:0000473 ! testis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/49/Seminiferous_tubule_and_sperm_low_mag.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6a/Gray1145.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/49/Seminiferous_tubule_and_sperm_low_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6a/Gray1145.png" xsd:anyURI
property_value: UBPROP:0000001 "Any of the coiled tubules located in the testes in which spermatozoa are produced.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010399", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "One of two or three twisted curved tubules in each lobule of the testis in which spermatogenesis occurs. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001363", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/SEMINIFEROUS+TUBULE"}
property_value: UBPROP:0000003 "Frogs among amphibians and the amniotes have males with testes that are composed of seminiferous tubules, which differ from ampullae in being long, highly convoluted ductules.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001363", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.688 and Figure 21-28", source="http://bgee.unil.ch/"}
@@ -173829,7 +173699,7 @@ intersection_of: UBERON:0001013 ! adipose tissue
intersection_of: composed_primarily_of CL:0000449 ! brown fat cell
relationship: capable_of GO:1990845 ! adaptive thermogenesis
relationship: composed_primarily_of CL:0000449 ! brown fat cell
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Brownfat_PETCT.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/69/Brownfat_PETCT.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Adipose tissue, cells of which contain multiple small lipid droplets.[FMA]" xsd:string {source="FMA"}
property_value: UBPROP:0000008 "especially abundant in newborns and in hibernating mammals" xsd:string
property_value: UBPROP:0000009 "thermogenesis" xsd:string
@@ -173852,7 +173722,7 @@ xref: UMLS:C0229289 {source="ncithesaurus:Lacrimal_Sac"}
xref: Wikipedia:Lacrimal_sac
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0002392 ! nasolacrimal duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
[Term]
id: UBERON:0001352
@@ -173916,7 +173786,7 @@ xref: WBbt:0006919
is_a: UBERON:0000475 ! organism subdivision
relationship: has_developmental_contribution_from UBERON:0000931 {evidence="cjm"} ! proctodeum
relationship: overlaps UBERON:0006866 ! terminal part of digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray408.png" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/507" xsd:anyURI
property_value: UBPROP:0000003 "Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000395", ontology="VHOG", source="ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
@@ -173943,7 +173813,7 @@ intersection_of: part_of UBERON:0035551 ! deep vasculature
relationship: branching_part_of UBERON:0002060 ! femoral artery
relationship: part_of UBERON:0035551 ! deep vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray548.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray548.png" xsd:anyURI
[Term]
id: UBERON:0001356
@@ -173965,7 +173835,7 @@ intersection_of: supplies UBERON:0007119 ! neck of femur
relationship: branching_part_of UBERON:0001355 {source="FMA"} ! deep femoral artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0007119 ! neck of femur
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c5/Circumflex_femoral_arteries.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c5/Circumflex_femoral_arteries.png" xsd:anyURI
[Term]
id: UBERON:0001359
@@ -174057,7 +173927,7 @@ xref: Wikipedia:Great_saphenous_vein
is_a: UBERON:0007318 ! saphenous vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001361 {source="FMA/obol"} ! femoral vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Great_saphenous_vein.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/51/Great_saphenous_vein.png" xsd:anyURI
[Term]
id: UBERON:0001366
@@ -174082,7 +173952,7 @@ intersection_of: UBERON:0022351 ! parietal serous membrane
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: attaches_to UBERON:0003697 ! abdominal wall
relationship: part_of UBERON:0002358 ! peritoneum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI
property_value: UBPROP:0000001 "Peritoneum attached to the abdominal wall.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010816", ontology="AAO", source="AAO:JMG"}
[Term]
@@ -174159,7 +174029,7 @@ relationship: contributes_to_morphology_of UBERON:0000956 ! cerebral cortex
relationship: contributes_to_morphology_of UBERON:0001870 ! frontal cortex
relationship: part_of UBERON:0001870 {source="MA", source="Wikipedia"} ! frontal cortex
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Ba4.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Ba4.png" xsd:anyURI
property_value: editor_note "TODO - in MA this is asserted to be part_of BOTH frontal and parietal cortex. in ABA these are disjoint. FMA makes no commitment beyond cerebral cortex. Wikipedia says frontal lobe. Check if species difference or difference in definition. Removed relationship: part_of UBERON:0001872 parietal lobe" xsd:string
property_value: UBPROP:0000001 "the area of the frontal lobe that is involved with integration of voluntary movements and with speech.[MP]" xsd:string {date_retrieved="2012-08-31", external_class="MP:0000800", ontology="MP", source="MGI:csmith"}
property_value: UBPROP:0000001 "The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html" xsd:string {source="NLX:143555"}
@@ -174191,7 +174061,7 @@ relationship: connected_to UBERON:0001533 ! subclavian artery
relationship: part_of UBERON:0001467 ! shoulder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0009472 ! axilla
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/88/Axillary_limits.PNG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/88/Axillary_limits.PNG" xsd:anyURI
property_value: UBPROP:0000008 "In human anatomy, the axillary artery is a large blood vessel that conveys oxygenated blood to the lateral aspect of the thorax, the axilla (armpit) and the upper limb. Its origin is at the lateral margin of the first rib, before which it is called the subclavian artery. After passing the lower margin of teres major it becomes the brachial artery." xsd:string
[Term]
@@ -174212,7 +174082,7 @@ xref: Wikipedia:Subscapular_artery
is_a: UBERON:0001637 ! artery
relationship: connected_to UBERON:0001394 ! axillary artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Axillary_branches.PNG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Axillary_branches.PNG" xsd:anyURI
[Term]
id: UBERON:0001415
@@ -174468,7 +174338,7 @@ intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0004452 ! carpal region
disjoint_from: UBERON:0012358 ! manual digitopodium bone
relationship: develops_from UBERON:0006213 ! carpus cartilage element
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg" xsd:anyURI
property_value: UBPROP:0000008 "In tetrapods, the carpals is the sole cluster of the bones in the wrist between the radius and ulna and the metacarpus. The bones of the carpus do not belong to individual fingers (or toes in quadrupeds), whereas those of the metacarpus do. The corresponding part of the foot is the tarsus. The carpal bones allow the wrist to move and rotate vertically, horizontally and laterally. In human anatomy, the main role of the carpus is to facilitate effective positioning of the hand and powerful use of the extensors and flexors of the forearm, but the mobility of individual carpal bones increase the freedom of movements at the wrist." xsd:string {source="Wikipedia:Carpus"}
[Term]
@@ -174536,7 +174406,7 @@ xref: Wikipedia:Epiphysis
is_a: UBERON:0005055 ! zone of long bone
relationship: contributes_to_morphology_of UBERON:0002495 ! long bone
relationship: seeAlso UBERON:0006776
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Cartilaginous expansion at the distal end of an anterior rib or transverse process that serves for the attachment of muscles suspending the pectoral girdle to the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000742", ontology="AAO", source="AAO:Pugener_2002"}
property_value: UBPROP:0000001 "Subdivision of long bone which forms its expanded proximal or distal articular end; together with other the subdivisions of long bone, it constitutes the long bone. Examples: proximal epiphysis of humerus, distal epiphysis of femur." xsd:string {source="FMA:24012"}
property_value: UBPROP:0000007 "epiphyseal" xsd:string
@@ -174738,7 +174608,7 @@ xref: UMLS:C1527391 {source="ncithesaurus:Chest"}
xref: Wikipedia:Chest
is_a: UBERON:0009569 {source="FMA-modified"} ! subdivision of trunk
relationship: part_of UBERON:0000915 {source="FMA", source="MA"} ! thoracic segment of trunk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Chest.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/db/Chest.jpg" xsd:anyURI
property_value: editor_note "FMA:24216 present in FMA1, but gone in subsequent versions" xsd:string
property_value: RO:0002171 UBERON:0000916
property_value: UBPROP:0000007 "pectoral" xsd:string
@@ -174816,7 +174686,7 @@ intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
relationship: develops_from UBERON:0010851 ! fibula cartilage element
relationship: postaxialmost_part_of UBERON:0010720 ! hindlimb zeugopod skeleton
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/16/Illu_lower_extremity.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/16/Illu_lower_extremity.jpg" xsd:anyURI
property_value: UBPROP:0000001 "One of the two long bones of endochondral origin of the hind-epipodium; it is a rather more slender bone than the tibia but of about the same length.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000891", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000007 "fibular" xsd:string
@@ -174854,7 +174724,7 @@ intersection_of: UBERON:0001474 ! bone element
intersection_of: part_of UBERON:0004454 ! tarsal region
disjoint_from: UBERON:0012359 ! pedal digitopodium bone
relationship: develops_from UBERON:0010541 ! tarsus cartilage element
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In primitive tetrapods, such as Trematops, the tarsus consists of three rows of bones. There are three proximal tarsals, the tibiale, intermedium, and fibulare, named for their points of articulation with the bones of the lower limb. These are followed by a second row of four bones, referred to as the centralia (singular: centrale), and then a row of five distal tarsals, each articulating with a single metatarsal. In the great majority of tetrapods, including all of those alive today, this simple pattern is modified by the loss and fusion of various of the bones.[3] In reptiles and mammals, there are normally just two proximal tarsals, the calcaneus (equivalent to the amphibian fibulare) and the talus (probably derived from a fusion of multiple bones). In mammals, including humans, the talus forms a hinge joint with the tibia, a feature especially well developed in the artiodactyls. The calcaneus is also modified, forming a heel for the attachment of the Achilles tendon. Neither of these adaptations is found in reptiles, which have a relatively simple structure to both bones.[3] The fifth distal tarsal disappears relatively early in evolution, with the remainder becoming the cuneiform and cuboid bones. Reptiles usually retain two centralia, while mammals typically have only one (the navicular).[3] In birds, the tarsus has disappeared, with the proximal tarsals having fused with the tibia, the centralia having disappeared, and the distal bones having fused with the metatarsals to form a single tarsometatarsus bone, effectively giving the leg a third segment" xsd:string {source="Wikipedia:Tarsus_(skeleton)"}
[Term]
@@ -174888,7 +174758,7 @@ intersection_of: part_of UBERON:0000983 ! metatarsus region
relationship: connected_to UBERON:0001447 ! tarsal bone
relationship: connected_to UBERON:0001449 ! phalanx of pes
relationship: part_of UBERON:0010545 ! metatarsus skeleton
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png" xsd:anyURI
[Term]
id: UBERON:0001449
@@ -174957,7 +174827,7 @@ relationship: has_part UBERON:0000018 {gci_filler="NCBITaxon:50557", gci_relatio
relationship: has_part UBERON:0000165 ! mouth
relationship: has_part UBERON:0011156 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! facial skeleton
relationship: has_skeleton UBERON:0011156 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! facial skeleton
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face." xsd:string {source="FMA:24728"}
property_value: UBPROP:0000001 "The area that extends from the median ocellus to the oral foramen[HAO]." xsd:string {source="HAO:0000316", source="http://api.hymao.org/api/ref/67791", taxon="NCBITaxon:7399"}
property_value: UBPROP:0000007 "facial" xsd:string
@@ -175059,7 +174929,7 @@ is_a: UBERON:0006058 ! multi-limb segment region
is_a: UBERON:0008785 ! upper limb segment
relationship: distally_connected_to UBERON:0002398 ! manus
relationship: proximally_connected_to UBERON:0001467 ! shoulder
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Upperarm.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Upperarm.jpg" xsd:anyURI
property_value: editor_note "currently declared as overlapping hand, as AOs disagree over whether some wrist parts are in the arm or hand" xsd:string
property_value: IAO:0000232 "this class refers to the combination of the stylopod and zeugopod of a forelimb. Sometimes (cf FMA), 'arm' denotes the stylopod only; sometimes (cf MA), 'arm' denotes the part of the forelimb covering both (i.e. shoulder to hand). Also note distinction between arm and forelimb: hand is part of forelimb, but not part of arm" xsd:string
property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000339", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"}
@@ -175092,7 +174962,7 @@ xref: VHOG:0000340
xref: Wikipedia:Elbow
is_a: UBERON:0008785 ! upper limb segment
relationship: part_of UBERON:0001460 {source="EHDAA2"} ! arm
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5c/Elbow_coude.JPG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/5c/Elbow_coude.JPG" xsd:anyURI
property_value: UBPROP:0000007 "cubital" xsd:string
property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group" xsd:string
@@ -175127,7 +174997,7 @@ xref: Wikipedia:Hip
is_a: UBERON:0000475 ! organism subdivision
relationship: overlaps UBERON:0001271 {source="FMA-modified"} ! pelvic girdle region
relationship: part_of UBERON:0010709 ! pelvic complex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Hip.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Hip.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The pelvic girdle is never joined by contributions of dermal bone. From its first appearance in placoderms, the pelvic girdle is exclusively endoskeletal. It arose from pterygiophores, perhaps several times, in support of the fin.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000346", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.333", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "coxal" xsd:string
property_value: UBPROP:0000012 "See notes for shoulder. in BTO this is part of the abdomen - this creates an inconsistency if limb and abdomen are spatially disjoint" xsd:string {external_ontology="BTO"}
@@ -175158,7 +175028,7 @@ xref: VHOG:0000347
is_a: UBERON:0008784 ! lower limb segment
relationship: part_of UBERON:0000978 ! leg
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Male_Knee_by_David_Shankbone.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Male_Knee_by_David_Shankbone.jpg" xsd:anyURI
[Term]
id: UBERON:0001466
@@ -175198,7 +175068,7 @@ intersection_of: UBERON:0002544 ! digit
intersection_of: part_of UBERON:0002387 ! pes
relationship: part_of UBERON:0012142 {source="PHENOSCAPE:ni"} ! pedal digitopodium region
relationship: part_of UBERON:5001466 ! pedal digit plus metapodial segment
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Toes.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Toes.jpg" xsd:anyURI
[Term]
id: UBERON:0001467
@@ -175231,7 +175101,7 @@ relationship: has_part UBERON:0016884 ! shoulder joint
relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: overlaps UBERON:0001421 {source="FMA-modified"} ! pectoral girdle region
relationship: part_of UBERON:0010708 ! pectoral complex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/90/Shoulderjoint.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/90/Shoulderjoint.PNG" xsd:anyURI
property_value: UBPROP:0000003 "(...) endochondral elements of the early tetrapod shoulder develop from two centers of ossification, giving rise to a scapula and a 'coracoid'.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000342", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.332", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "In FMA, the shoulder is part of the pectoral girdle region. in MA, shoulder structures like shoulder joints, bones, nerves etc are part of the shoulder and the forelimb. E.g. humerus is a shoulder bone" xsd:string {external_ontology="FMA"}
@@ -175284,7 +175154,7 @@ intersection_of: connects UBERON:0000975 ! sternum
intersection_of: connects UBERON:0001105 ! clavicle bone
relationship: connects UBERON:0000975 {notes="clavicular notch of the manubrium sterni"} ! sternum
relationship: connects UBERON:0001105 {notes="sternal end of the clavicle and first rib"} ! clavicle bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray325.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray325.png" xsd:anyURI
[Term]
id: UBERON:0001470
@@ -175318,7 +175188,7 @@ relationship: adjacent_to UBERON:0006657 ! glenoid fossa
relationship: connects UBERON:0000976 ! humerus
relationship: connects UBERON:0006849 ! scapula
relationship: part_of UBERON:0004753 ! scapulocoracoid
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray327.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Gray327.png" xsd:anyURI
property_value: editor_note "note that in this ontology 'glenoid fossa' is a cavity (consistent with FMA) - consider adding a class for the surface of the scapula that is adjacent to this cavity, and making a more explicit connects relationship" xsd:string
property_value: UBPROP:0000012 "in FMA, this is part of the bony pectoral girdle, alongside the skeleton of pectoral girdle" xsd:string {external_ontology="FMA"}
@@ -175360,7 +175230,7 @@ is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0001593 ! venous plexus
intersection_of: part_of UBERON:0000996 ! vagina
relationship: part_of UBERON:0000996 ! vagina
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
[Term]
id: UBERON:0001473
@@ -175398,7 +175268,7 @@ relationship: contributes_to_morphology_of UBERON:0002405 ! immune system
relationship: has_part UBERON:0002391 ! lymph
relationship: part_of UBERON:0004536 ! lymph vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/44/Illu_lymph_capillary.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/44/Illu_lymph_capillary.jpg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:8342 {source="DOI:10.1152/japplphysiol.00201.2013"}
property_value: UBPROP:0000001 "A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005105", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "A vessel that contains or conveys lymph.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011005", ontology="AAO", source="AAO:EJS"}
@@ -175506,7 +175376,7 @@ relationship: has_muscle_origin UBERON:0006849 {notes="the anterior border and u
relationship: innervated_by UBERON:0001493 {source="dbpedia"} ! axillary nerve
relationship: part_of UBERON:0008713 {source="EHDAA2"} ! pectoral girdle and thoracic body wall skeletal muscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Deltoideus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Deltoideus.png" xsd:anyURI
property_value: UBPROP:0000001 "Muscle which originates as three heads, the pars externalis, pars clavicularis, and pars scapularis. The pars externalis originates from the lateral border of the omosternum and inserts on the distal portion of the humerus. The pars clavicularis originates from the ventro-lateral surface of the clavicle and inserts on the deltoid crest of the humerus. The pars scapularis originates from the lateral surface of the clavicle and inserts on the deltoid crest of the humerus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010716", ontology="AAO", source="AAO:MEJ"}
[Term]
@@ -175534,7 +175404,7 @@ is_a: UBERON:0013630 {source="UBERON:cjm"} ! short bone
is_a: UBERON:0013631 ! sesamoid element
intersection_of: UBERON:0013631 ! sesamoid element
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray350.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray350.png" xsd:anyURI
[Term]
id: UBERON:0001480
@@ -175619,8 +175489,8 @@ intersection_of: has_part UBERON:0007616 ! layer of synovial tissue
intersection_of: surrounds UBERON:0002217 ! synovial joint
relationship: has_part UBERON:0007616 ! layer of synovial tissue
relationship: surrounds UBERON:0002217 ! synovial joint
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png" xsd:anyURI
property_value: UBPROP:0000012 "check ncita" xsd:string {external_ontology="ncit"}
[Term]
@@ -175658,7 +175528,7 @@ relationship: connects UBERON:0002446 ! patella
relationship: develops_from UBERON:0006256 {evidence="definitional"} ! knee joint primordium
relationship: part_of UBERON:0001465 ! knee
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Knee.agr.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ca/Knee.agr.jpg" xsd:anyURI
[Term]
id: UBERON:0001487
@@ -175724,7 +175594,7 @@ relationship: connects UBERON:0001445 ! skeleton of pes
relationship: connects UBERON:0001446 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! fibula
relationship: connects UBERON:0010720 ! hindlimb zeugopod skeleton
relationship: overlaps UBERON:0002387 ! pes
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI
property_value: UBPROP:0000008 "todo - accurately represent different types of ankle joint" xsd:string
[Term]
@@ -175812,7 +175682,7 @@ intersection_of: connects UBERON:0010703 ! forelimb zeugopod skeleton
relationship: connects UBERON:0009880 ! carpal skeleton
relationship: connects UBERON:0010703 ! forelimb zeugopod skeleton
relationship: part_of UBERON:0004452 ! carpal region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png" xsd:anyURI
property_value: UBPROP:0000012 "in FMA this includes radio-carpal and radio-ulnar *ligaments*" xsd:string {external_ontology="FMA"}
[Term]
@@ -175837,8 +175707,8 @@ is_a: UBERON:0003433 ! arm nerve
relationship: innervates UBERON:0009472 ! axilla
relationship: part_of UBERON:0001814 {source="MA"} ! brachial nerve plexus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ea/Brachial_plexus_2.svg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d4/Brachial_plexus.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ea/Brachial_plexus_2.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d4/Brachial_plexus.jpg" xsd:anyURI
[Term]
id: UBERON:0001495
@@ -175872,7 +175742,7 @@ is_a: UBERON:0003830 ! thoracic segment muscle
is_a: UBERON:0008196 {source="FMA"} ! muscle of pectoral girdle
relationship: develops_from UBERON:0010984 ! pectoral pre-muscle mass
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png" xsd:anyURI
property_value: UBPROP:0000001 "Muscle which is comprised of three heads. The anterior head is the portio epicoracoidea that originates on the epicoracoid cartilage and inserts on the deltoid crest of the humerus. The next more posterior head, portio sternalis, originates on the sternum and inserts in the groove next to the deltoid crest of the humerus. The most posterior head, portio abdominalis, arises from the M. rectus abdominis and inserts on the deltoid crest of the humerus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010727", ontology="AAO", source="AAO:MEJ"}
[Term]
@@ -175903,7 +175773,7 @@ relationship: has_developmental_contribution_from UBERON:0002061 ! truncus arter
relationship: has_developmental_contribution_from UBERON:0005432 ! aortic sac
relationship: part_of UBERON:0001515 ! thoracic aorta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -176028,7 +175898,7 @@ relationship: has_developmental_contribution_from UBERON:0005432 ! aortic sac
relationship: has_developmental_contribution_from UBERON:0005613 ! left dorsal aorta
relationship: part_of UBERON:0001515 ! thoracic aorta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: IAO:0000232 "Do not confuse with aortic arch" xsd:string
@@ -176141,7 +176011,7 @@ relationship: develops_from UBERON:0005805 {source="Wikipedia"} ! dorsal aorta
relationship: has_developmental_contribution_from UBERON:0005613 ! left dorsal aorta
relationship: has_developmental_contribution_from UBERON:0005622 ! right dorsal aorta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000011 "results from fusion of left and right dorsal aortae" xsd:string
@@ -176175,7 +176045,7 @@ intersection_of: UBERON:0005800 ! section of aorta
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: contributes_to_morphology_of UBERON:0000947 ! aorta
relationship: part_of UBERON:0000915 ! thoracic segment of trunk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/75/Gray530.png" xsd:anyURI
[Term]
id: UBERON:0001516
@@ -176210,7 +176080,7 @@ relationship: contributes_to_morphology_of UBERON:0001514 ! descending aorta
relationship: overlaps UBERON:0000916 ! abdomen
relationship: part_of UBERON:0001514 {source="FMA"} ! descending aorta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/af/Gray531.png" xsd:anyURI
property_value: editor_note "Many of the branches of the abdominal aorta in mammals may be branches of the dorsal aorta in other vertebrates" xsd:string
[Term]
@@ -176309,7 +176179,7 @@ relationship: channels_from UBERON:0001508 ! arch of aorta
relationship: connected_to UBERON:0001508 ! arch of aorta
relationship: part_of UBERON:0007204 ! brachiocephalic vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -176344,7 +176214,7 @@ relationship: connected_to UBERON:0001508 ! arch of aorta
relationship: develops_from UBERON:0004363 {source="Wikipedia"} ! pharyngeal arch artery
relationship: existence_starts_during UBERON:0000068 ! embryo stage
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: editor_note "we follow the FMA and treat the artery as a tree-structure - here we include the internal and external as parts. For the part that excludes the branches, see 'trunk of common carotid artery'" xsd:string
property_value: IAO:0000232 "This class represents the adult and developing structures'" xsd:string
property_value: UBPROP:0000011 "in birds and reptiles, develops from arch III and parts of ventral and dorsal aortae" xsd:string
@@ -176370,7 +176240,7 @@ is_a: UBERON:0001530 {source="FMA"} ! common carotid artery plus branches
relationship: branching_part_of UBERON:0001529 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! brachiocephalic artery
relationship: connected_to UBERON:0001529 ! brachiocephalic artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: UBPROP:0000012 "placement of the MA class here is not strictly correct, as the MA class does not include the branches" xsd:string
[Term]
@@ -176414,7 +176284,7 @@ relationship: develops_from UBERON:2001053 {source="cjm"} ! future internal caro
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0000955 ! brain
relationship: supplies UBERON:0000970 ! eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray513.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9c/Gray513.png" xsd:anyURI
property_value: UBPROP:0000001 "Each of two arteries starting at the bifurcation of the common carotid arteries through which blood circulates to many structures and organs in the head. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000267", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Internal+carotid+artery"}
property_value: UBPROP:0000001 "One of the major arteries of the head, it is the as the cranial continuation of the aortic arches and the dorsal aorta. It curves ventrally before resuming a dorsal course as it enters the head proper, and it lies ventral to the internal jugular vein. The internal carotid artery gives off palatine, ophthalmic, and cerebral branches by stage NF stage 41.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011054", ontology="AAO", source="PMID:12606281"}
@@ -176457,7 +176327,7 @@ relationship: develops_from UBERON:0005622 {source="EHDAA2"} ! right dorsal aort
relationship: overlaps UBERON:0000915 ! thoracic segment of trunk
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0004710 ! pectoral appendage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: editor_note "Developmental relationships should be added (intersegmental artery and right dorsal aorta in EHDAA2, occipitovertebral artery in XAO)" xsd:string
property_value: UBPROP:0000001 "Artery which supplies blood via branches to the various muscles of the shoulder region and to the forelimb.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010232", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "In human anatomy, the subclavian artery is a major artery of the upper thorax that mainly supplies blood to the head and arms. It is located below the clavicle, hence the name. There is a left subclavian and a right subclavian. On the left side of the body, the subclavian comes directly off the arch of aorta. On the right side of the body, the subclavian arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery. The usual branches of the subclavian on both sides of the body are the vertebral artery, the internal thoracic artery, the thyrocervical trunk, the costocervical trunk and the dorsal scapular artery. The subclavian becomes the axillary artery at the lateral border of the first rib[WP]" xsd:string {source="Wikipedia:Subclavian_artery"}
@@ -176488,7 +176358,7 @@ relationship: connected_to UBERON:0001529 ! brachiocephalic artery
relationship: develops_from UBERON:0003121 {gci_relation="part_of", gci_filler="NCBITaxon:40674", notes="right arch 4 in human", source="embryology.ch"} ! pharyngeal arch artery 4
relationship: in_right_side_of UBERON:0000468 ! multicellular organism
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: UBPROP:0000008 "in humans, arises from the relatively short brachiocephalic artery (trunk) when it bifurcates into the subclavian and the right common carotid artery" xsd:string
property_value: UBPROP:0000011 "proximal part arises from right 4th aortic arch in humans" xsd:string
@@ -176511,7 +176381,7 @@ xref: UMLS:C0226087 {source="ncithesaurus:Left_Common_Carotid_Artery"}
xref: Wikipedia:Left_common_carotid_artery
is_a: UBERON:0001530 {source="FMA"} ! common carotid artery plus branches
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000012 "placement of the MA class here is not strictly correct, as the MA class does not include the branches" xsd:string
@@ -176538,7 +176408,7 @@ is_a: UBERON:0001638 ! vein
relationship: overlaps UBERON:0001465 ! knee
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001361 {source="FMA/obol"} ! femoral vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray609.png" xsd:anyURI
[Term]
id: UBERON:0001545
@@ -176560,7 +176430,7 @@ is_a: UBERON:0010370 {source="MA"} ! tibial vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001361 {source="FMA/obol"} ! femoral vein
relationship: tributary_of UBERON:0001544 {source="FMA/obol"} ! popliteal vein
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4e/Gray440_color.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4e/Gray440_color.png" xsd:anyURI
[Term]
id: UBERON:0001547
@@ -176584,7 +176454,7 @@ xref: Wikipedia:Small_saphenous_vein
is_a: UBERON:0007318 ! saphenous vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001544 {source="FMA"} ! popliteal vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/62/Gray582.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/62/Gray582.png" xsd:anyURI
[Term]
id: UBERON:0001549
@@ -176643,7 +176513,7 @@ is_a: UBERON:0003644 ! kidney arterial blood vessel
relationship: branching_part_of UBERON:0009885 ! interlobar artery
relationship: part_of UBERON:0001225 {source="MA"} ! cortex of kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg" xsd:anyURI
[Term]
id: UBERON:0001554
@@ -176744,8 +176614,8 @@ xref: VHOG:0000406
xref: Wikipedia:Upper_respiratory_tract
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: has_part UBERON:0000004 ! nose
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI
property_value: RO:0002171 UBERON:0001558
property_value: UBPROP:0000012 "Some specify that the glottis (vocal cords) is the defining line between the upper and lower respiratory tracts;[2] yet even others make the line at the cricoid cartilage. The FMA includes nose, nasopharynx, oropharynx and larynx[WP]" xsd:string {external_ontology="FMA"}
@@ -176768,8 +176638,8 @@ xref: Wikipedia:Lower_respiratory_tract
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: has_part UBERON:0000170 ! pair of lungs
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI
[Term]
id: UBERON:0001560
@@ -176839,7 +176709,7 @@ relationship: develops_from UBERON:0010059 {source="EHDAA2"} ! hypoglossal cord
relationship: has_muscle_insertion UBERON:0009471 {source="Wikipedia"} ! dorsum of tongue
relationship: has_muscle_origin UBERON:0006606 ! mandibular symphysis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Genioglossus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Genioglossus.png" xsd:anyURI
property_value: UBPROP:0000001 "Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000847", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/genioglossus"}
property_value: UBPROP:0000001 "Makes up bulk of tongue in frogs and salamanders; makes up entire tongue in caecilians.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010660", ontology="AAO", source="AAO:BMZ"}
property_value: UBPROP:0000001 "see Intrinsic Tongue.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"}
@@ -176875,7 +176745,7 @@ relationship: attaches_to UBERON:0001723 ! tongue
relationship: has_muscle_insertion UBERON:0001723 ! tongue
relationship: has_muscle_origin UBERON:0001685 {notes="lingual process in horse", source="dbpedia"} ! hyoid bone
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Hyoglossus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Hyoglossus.png" xsd:anyURI
property_value: UBPROP:0000001 "Makes up part of the tongue in frogs and salamanders.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010663", ontology="AAO", source="AAO:BMZ"}
property_value: UBPROP:0000001 "The hyoglossus is a muscle that attaches to the hyoid and tongue and is innervated by Cranial Nerve XII.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"}
property_value: UBPROP:0000002 "relationship loss: subclass hyobranchial muscles (AAO:0000224)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010663", ontology="AAO"}
@@ -176974,7 +176844,7 @@ intersection_of: UBERON:0014892 ! skeletal muscle organ
intersection_of: innervated_by UBERON:0001647 ! facial nerve
relationship: develops_from UBERON:0003066 {source="FEED", source="Wikipedia"} ! pharyngeal arch 2
relationship: innervated_by UBERON:0001647 ! facial nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png" xsd:anyURI
[Term]
id: UBERON:0001579
@@ -177032,7 +176902,7 @@ relationship: develops_from UBERON:0003050 {source="ISBN:0471888893"} ! olfactor
relationship: extends_fibers_into UBERON:0002264 ! olfactory bulb
relationship: innervates UBERON:0001997 {source="ISBN:0471888893"} ! olfactory epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/be/Gray771.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/be/Gray771.png" xsd:anyURI
property_value: UBPROP:0000001 "Nerve that carries information from the olfactory epithelium through the olfactory bulb to the olfactory cortex of the telencephalon.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010088", ontology="AAO", source="AAO:DSM"}
property_value: UBPROP:0000001 "Segment of neural tree organ which is continuous with the olfactory epithelium and an olfactory bulb[FMA:46787]." xsd:string {source="FMA:46787"}
property_value: UBPROP:0000001 "The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB[MESH:A08.800.800.120.640]." xsd:string {source="MESH:A08.800.800.120.640"}
@@ -177061,7 +176931,7 @@ intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism
relationship: channels_from UBERON:0001508 ! arch of aorta
relationship: in_left_side_of UBERON:0000468 ! multicellular organism
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray506.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000008 "in humans, branches off the arch of aorta" xsd:string
@@ -177101,7 +176971,7 @@ intersection_of: drains UBERON:0000153 ! anterior region of body
relationship: connected_to UBERON:0002078 ! right cardiac atrium
relationship: drains UBERON:0000153 ! anterior region of body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Venenwinkel.png" xsd:anyURI
property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001195", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "The mouse has both left and right anterior vena cava. adult humans only have a right. Postnatally the left regresses and becomes non-functional (Wessels and Sedmera 2003). In the mouse, The right pulmonary vein passes dorsal to the right superior vena cava, the left pulmonary dorsal to the left superior vena cava (Biology of the Laboratory Mouse, Green)." xsd:string
@@ -177133,7 +177003,7 @@ relationship: connected_to UBERON:0003711 ! brachiocephalic vein
relationship: drains UBERON:0000955 ! brain
relationship: drains UBERON:0001456 ! face
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png" xsd:anyURI
property_value: UBPROP:0000001 "Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010236", ontology="AAO", source="AAO:BJB"}
[Term]
@@ -177162,7 +177032,7 @@ is_a: UBERON:0001638 ! vein
relationship: connected_to UBERON:0003711 ! brachiocephalic vein
relationship: drains UBERON:0004710 ! pectoral appendage
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI
property_value: UBPROP:0000001 "Vein which collects blood from the forelimb via the brachial veins and from the muscles and skin of the trunk via the anterior epigastric and lateral veins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010510", ontology="AAO", source="AAO:BJB"}
[Term]
@@ -177228,7 +177098,7 @@ is_a: UBERON:0005629 ! vascular plexus
intersection_of: UBERON:0005629 ! vascular plexus
intersection_of: composed_primarily_of UBERON:0001638 ! vein
relationship: composed_primarily_of UBERON:0001638 ! vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI
[Term]
id: UBERON:0001605
@@ -177255,7 +177125,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle
relationship: part_of UBERON:0001775 {source="FMA"} ! ciliary body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI
[Term]
id: UBERON:0001606
@@ -177319,7 +177189,7 @@ relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurecto
relationship: has_muscle_antagonist UBERON:0001608 {source="dbpedia"} ! dilatator pupillae
relationship: has_muscle_insertion UBERON:0001769 {notes="encircles iris", source="dbpedia"} ! iris
relationship: has_muscle_origin UBERON:0001769 {notes="encircles iris", source="dbpedia"} ! iris
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png" xsd:anyURI
property_value: UBPROP:0000008 "In humans, it functions to constrict the pupil in bright light or during accommodation. Its dimensions are about 0.75 mm wide by 0.15 mm thick. It is controlled by parasympathetic fibers that originate from the Edinger-Westphal nucleus, travel along the oculomotor nerve (CN III), synapse in the ciliary ganglion, and then enter the eye via the short ciliary nerves. Initially, all the myocytes are of the smooth muscle type, but much later in life, so that ultimately most cells are of the striated muscle type. [WP,unvetted]" xsd:string
property_value: UBPROP:0000008 "WP says: It is found in vertebrates and some cephalopods; this class refers to the vertebrate structure" xsd:string
property_value: UBPROP:0000009 "constricts iris" xsd:string
@@ -177364,7 +177234,7 @@ relationship: has_muscle_antagonist UBERON:0001607 {source="dbpedia"} ! sphincte
relationship: has_muscle_insertion UBERON:0001769 {notes="inner margins of iris", source="dbpedia"} ! iris
relationship: has_muscle_origin UBERON:0001769 {notes="outer margins of iris", source="dbpedia"} ! iris
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray878.png" xsd:anyURI
property_value: UBPROP:0000009 "It is innervated by the sympathetic system, which acts by releasing noradrenaline, which acts on alpha1-receptors. Thus, when presented with a threatening stimuli that activates the fight-or-flight response, this innervation dilates the iris, thus temporarily letting more light reach the retina" xsd:string
[Term]
@@ -177391,7 +177261,7 @@ intersection_of: supplies UBERON:0001723 ! tongue
relationship: in_lateral_side_of UBERON:0001723 {source="FMA-abduced-lr"} ! tongue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001723 ! tongue
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3c/Lingual_artery.PNG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/3c/Lingual_artery.PNG" xsd:anyURI
property_value: UBPROP:0000001 "Part of the external carotid which supplies blood to the tongue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010492", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000002 "relationship loss: part_of external carotid (AAO:0010218)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010492", ontology="AAO"}
@@ -177417,7 +177287,7 @@ intersection_of: branching_part_of UBERON:0001070 ! external carotid artery
intersection_of: supplies UBERON:0001456 ! face
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001456 ! face
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png" xsd:anyURI
[Term]
id: UBERON:0001613
@@ -177442,7 +177312,7 @@ intersection_of: supplies UBERON:0002377 ! muscle of neck
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0000403 ! scalp
relationship: supplies UBERON:0002377 ! muscle of neck
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Gray508.png" xsd:anyURI
[Term]
id: UBERON:0001616
@@ -177470,7 +177340,7 @@ intersection_of: directly_develops_from UBERON:0003118 ! pharyngeal arch artery
relationship: connected_to UBERON:0001070 ! external carotid artery
relationship: directly_develops_from UBERON:0003118 ! pharyngeal arch artery 1
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray510.png" xsd:anyURI
property_value: UBPROP:0000011 "...1st pair undergoes partial regression, the remnants of which becomes part of the maxillary arteries" xsd:string {source="http://download.videohelp.com/vitualis/med/Vascular_Devt.html"}
[Term]
@@ -177499,7 +177369,7 @@ is_a: UBERON:0003496 ! head blood vessel
is_a: UBERON:0004573 ! systemic artery
relationship: branching_part_of UBERON:0001532 ! internal carotid artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000001 "Part of internal carotid which carries blood via branches to the eye, the eye muscles, and eyelids.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010497", ontology="AAO", source="AAO:BJB"}
@@ -177532,7 +177402,7 @@ xref: ZFA:0005812
is_a: UBERON:0003498 ! heart blood vessel
is_a: UBERON:0004573 ! systemic artery
relationship: supplies UBERON:0002349 ! myocardium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png" xsd:anyURI
[Term]
id: UBERON:0001622
@@ -177556,7 +177426,7 @@ intersection_of: supplies UBERON:0001817 ! lacrimal gland
relationship: branching_part_of UBERON:0001619 {source="FMA"} ! ophthalmic artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001817 ! lacrimal gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray514.png" xsd:anyURI
[Term]
id: UBERON:0001628
@@ -177594,7 +177464,7 @@ relationship: branching_part_of UBERON:0001532 {source="FMA", source="ZFA"} ! in
relationship: in_lateral_side_of UBERON:0003709 {source="FMA-abduced-lr"} ! circle of Willis
relationship: part_of UBERON:0003709 ! circle of Willis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery. Isogai et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005001", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000008 "todo - verify ZFA link: An artery that connects caudal division of the internal carotid artery and the basal communicating artery to the basilar artery" xsd:string
@@ -177721,7 +177591,7 @@ intersection_of: UBERON:0003920 ! venous blood vessel
intersection_of: channel_for UBERON:0013756 ! venous blood
relationship: channel_for UBERON:0013756 ! venous blood
relationship: channels_from UBERON:0001982 ! capillary
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg" xsd:anyURI
property_value: editor_note "TODO - check with MA - vein vs venous blood vessel" xsd:string
property_value: UBPROP:0000001 "Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010212", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001743", ontology="VHOG", source="DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006)", source="http://bgee.unil.ch/"}
@@ -177758,7 +177628,7 @@ relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="
relationship: overlaps UBERON:0002107 ! liver
relationship: part_of UBERON:0010194 ! hepatic portal system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Gray591.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000003 "Adults of all vertebrates lose the vitelline veins and establish a single large hepatic portal vein (...) by the selective retention of parts of the left and right subintestinals and of several anastomoses that occur between them within and just posterior to the liver.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000642", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.265", source="http://bgee.unil.ch/"}
@@ -177800,7 +177670,7 @@ relationship: indirectly_supplies UBERON:0000945 {source="ISBN:0073040584"} ! st
relationship: indirectly_supplies UBERON:0002106 {source="ISBN:0073040584"} ! spleen
relationship: indirectly_supplies UBERON:0002107 {source="ISBN:0073040584"} ! liver
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png" xsd:anyURI
[Term]
id: UBERON:0001645
@@ -177864,7 +177734,7 @@ relationship: innervates UBERON:0000165 ! mouth
relationship: innervates UBERON:0011648 ! jaw muscle
relationship: innervates UBERON:1000021 ! skin of face
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/99/Gray778_Trigeminal.png" xsd:anyURI
property_value: UBPROP:0000001 "Nerve consists of motor and sensory components. Ganglion cells of the sensory component form the proximal part of the trigeminal (Gasserian) ganglion. From the ganglion 3 major rami innervate jaws, snout, and buccal roof.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010470", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000704", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "the ophthalmic usually usually merges with the other two. In some vertebrates, the ophthalmic emerges from the brain separately[Kardong] The trigeminal nerve has 3 branches in mammals - similar branches are present in nonmammalian vertebrates, but in some a separate profundus nerve that corresponds to opthalmic branch in mammls" xsd:string {source="ISBN:0471888893"}
@@ -177931,7 +177801,7 @@ relationship: has_developmental_contribution_from UBERON:0005239 {source="Wikipe
relationship: innervates UBERON:0001577 ! facial muscle
relationship: part_of UBERON:0001033 {source="ZFA"} ! gustatory system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Cranial_nerve_VII.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Cranial_nerve_VII.svg" xsd:anyURI
property_value: UBPROP:0000001 "Slender nerve composed of branchiomotor and visceral efferent fibers innervating the mouth and various muscles within the jaw. Sensory components innervate the bucccal roof and somatomotor components innervate the depressor musculature and muscle interhyoideus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010472", ontology="AAO", source="AAO:DSM"}
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000706", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"}
@@ -177999,7 +177869,7 @@ relationship: extends_fibers_into UBERON:0001720 ! cochlear nucleus
relationship: innervates UBERON:0001844 ! cochlea
relationship: part_of UBERON:0002105 ! vestibulo-auditory system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png" xsd:anyURI
property_value: UBPROP:0000001 "Nerve primarily composed of special somatic afferent fibers innervating the inner ear, and is involved in balance, position, and hearing.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010473", ontology="AAO", source="AAO:DSM"}
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000695", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"}
@@ -178055,7 +177925,7 @@ relationship: innervates UBERON:0001727 ! taste bud
relationship: innervates UBERON:0006562 ! pharynx
relationship: part_of UBERON:0001033 ! gustatory system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI
property_value: UBPROP:0000001 "Small nerve consisting of branchiomotor and visceral efferent and afferent fibers which innervate the m. subarculais rectus I, dorsal buccal mucosa, and the tongue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010474", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000701", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"}
@@ -178111,7 +177981,7 @@ relationship: innervates UBERON:0001571 ! genioglossus muscle
relationship: innervates UBERON:0001572 ! hyoglossus muscle
relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ef/Gray794.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ef/Gray794.png" xsd:anyURI
property_value: RO:0002174 NCBITaxon:8292
property_value: UBPROP:0000001 "Cranial nerve that innervates muscles in the tongue. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-14, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000693", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "In amphibians, represents the hypoglossal nerve in amniotes. Innverates mm. geniohyoideus, genioglossus, hyoglossus, rectus cervicis" xsd:string {source="ISBN:080184780X"}
@@ -178143,8 +178013,8 @@ intersection_of: supplies UBERON:0002167 ! right lung
relationship: connected_to UBERON:0002333 ! pulmonary trunk
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002167 ! right lung
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
property_value: editor_note "TODO - add class 'pulmonary artery tree organ'" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -178173,8 +178043,8 @@ intersection_of: supplies UBERON:0002168 ! left lung
relationship: connected_to UBERON:0002333 ! pulmonary trunk
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002168 ! left lung
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray504.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
property_value: editor_note "TODO - add class 'pulmonary artery tree organ'" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -178203,7 +178073,7 @@ is_a: UBERON:0009141 ! craniocervical region vein
relationship: part_of UBERON:0001456 ! face
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001586 {source="FMA"} ! internal jugular vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png" xsd:anyURI
property_value: UBPROP:0000001 "Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010513", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000012 "MA and NCITA also has 'anterior facial vein'" xsd:string {external_ontology="MA"}
@@ -178231,7 +178101,7 @@ intersection_of: UBERON:0001638 ! vein
intersection_of: drains UBERON:0001893 ! telencephalon
relationship: drains UBERON:0001893 ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Gray568.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Gray568.png" xsd:anyURI
property_value: UBPROP:0000202 FMA:70861
[Term]
@@ -178309,7 +178179,7 @@ intersection_of: UBERON:0001714 ! cranial ganglion
intersection_of: extends_fibers_into UBERON:0001645 ! trigeminal nerve
relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve
relationship: immediate_transformation_of UBERON:0006304 {source="Bgee:AN"} ! future trigeminal ganglion
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray776.png" xsd:anyURI
property_value: editor_note "consider renaming this 'trigeminal ganglion complex'. The complex may be fused (amniotes) partially fused (xenopus) or separate (sharks)" xsd:string
property_value: UBPROP:0000001 "A prominent collection of touch-sensory neurons of the trigeminal or fifth cranial nerve, positioned beside the brain between the eye and the ear. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000295", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000008 "In Xenopus, the profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24." xsd:string {source="PMID:21452441", source="XAO:0004093"}
@@ -178345,7 +178215,7 @@ relationship: overlaps UBERON:0003113 {notes="interparietal (postparietal)"} ! d
relationship: part_of UBERON:0005902 {source="FMA"} ! occipital region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: surrounds UBERON:0003687 ! foramen magnum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/27/Gray194.png" xsd:anyURI
property_value: UBPROP:0000008 "formed from the sclerotome of the occipital somites. It is not present in living or fossil agnathans or cartilaginous fishes, but appears to have arisen in parallel in many bony fishes. Incorporation of the occipital ver- tebrae into the skull was associated with the annexation of the upper part of the spinal cord into the brain, together with the first 2 spinal nerves as cranial nerves XI and XII" xsd:string {source="PMID:11523816"}
property_value: UBPROP:0000008 "fusion of basi-, exo- and supra-occipitals (and maybe tabular)" xsd:string {source="Kardong"}
@@ -178389,7 +178259,7 @@ relationship: overlaps UBERON:0002241 {notes="orbito pre and basi sphenoid"} ! c
relationship: overlaps UBERON:0003113 {notes="pterygoid process"} ! dermatocranium
relationship: overlaps UBERON:0008895 {notes="alisphenoid"} ! splanchnocranium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI
property_value: UBPROP:0000012 "part of viscerocranium (facial skeleton) in FMA" xsd:string {external_ontology="FMA"}
[Term]
@@ -178417,7 +178287,7 @@ relationship: overlaps UBERON:0002241 {notes="petrosal"} ! chondrocranium
relationship: overlaps UBERON:0003113 {notes="squamosal plus angular", notes="temporal series"} ! dermatocranium
relationship: overlaps UBERON:0008895 {notes="styloid process"} ! splanchnocranium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI
property_value: UBPROP:0000008 "fusion of squamosal + angular (tympanic annulus) [derm.] + petrosal (prootic + opisthotic)" xsd:string {source="chond."}
property_value: UBPROP:0000008 "In many mammals, as in humans, the petrosal, ectotympanic and squamosal bones synostose to form the temporal bone + styloid process" xsd:string
property_value: UBPROP:0000010 "The temporal bone consists of four parts: * Squama temporalis * Mastoid portion * Petrous portion (Petrosal ridge) * Tympanic part[WP]." xsd:string {source="[WP]"}
@@ -178456,7 +178326,7 @@ relationship: develops_from UBERON:0006227 {evidence="definitional"} ! ethmoid b
relationship: part_of UBERON:0002517 ! basicranium
relationship: part_of UBERON:0011241 ! ethmoid region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cranial_bones2.jpg" xsd:anyURI
property_value: UBPROP:0000001 "A light spongy bone located between the eye sockets, forming part of the walls and septum of the superior nasal cavity, and containing perforations for the passage of olfactory nerve fibers. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001317", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/ethmoid+bone"}
property_value: UBPROP:0000003 "The ethmoid region of the chondrocranium and the nasal capsules, which were largely unossified in early tetrapods and ancestral amniotes, are represented in mammals by the ethmoid and turbinates bones, respectively.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001317", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.259", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ethmoidal" xsd:string
@@ -178492,7 +178362,7 @@ relationship: has_developmental_contribution_from UBERON:0003066 {source="Wikipe
relationship: has_developmental_contribution_from UBERON:0003114 {source="Wikipedia"} ! pharyngeal arch 3
relationship: part_of UBERON:0010272 ! hyoid apparatus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Gray186.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1f/Gray186.png" xsd:anyURI
property_value: UBPROP:0000001 "Paired processes that extend posterolaterally from the posterior margin of the hyoid plate. These processes are the ossified posteromedial processes and invest the laryngeal apparatus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000684", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: part_of hyoid plate (AAO:0000664)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000684", ontology="AAO"}
property_value: UBPROP:0000008 "The hyoid bone is derived from the lower half of the second gill arch in fish, which separates the first gill slit from the spiracle. In many animals, it also incorporates elements of other gill arches, and has a correspondingly greater number of cornua. Amphibians and reptiles may have many cornua, while mammals (including humans) have two pairs, and birds only one. In birds, and some reptiles, the body of the hyoid is greatly extended forward, creating a solid bony support for the tongue. The howler monkey Alouatta has a pneumatized hyoid bone, one of the few cases of postcranial pneumatization of bones outside Saurischia." xsd:string {seeAlso="https://github.com/obophenotype/uberon/issues/548", source="WP"}
@@ -178532,7 +178402,7 @@ is_a: UBERON:0003457 ! head bone
is_a: UBERON:0035130 ! auditory ossicle endochondral element
intersection_of: UBERON:0035130 ! auditory ossicle endochondral element
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b0/Illu_auditory_ossicles.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b0/Illu_auditory_ossicles.jpg" xsd:anyURI
property_value: editor_note "This should probably be restricted to mammals - the AAO/XAO structures may group non-homologous structures [Wikipedia:Evolution_of_mammalian_auditory_ossicles] see https://github.com/seger/aao/issues/5." xsd:string
property_value: UBPROP:0000001 "The small bones of the middle ear: incus, malleus, and stapes. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000461", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/auditory+ossicles"}
property_value: UBPROP:0000003 "Additional structural analysis within a phylogenetic context has led to the remarkable discovery that in synapsids, thought to be ancestral to mammals, both the quadrate and articular have become reduced and less firmly articulated with their surrounding bones, reducing their jaw-joint-bearing role. This trend culminated with the incorporation of the quadrate, the columella (which remains articulated with the quadrate), and the articular into the expanded middle ear in mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000461", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.695", source="http://bgee.unil.ch/"}
@@ -178577,7 +178447,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
relationship: capable_of GO:0050910 ! detection of mechanical stimulus involved in sensory perception of sound
relationship: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0002105 ! vestibulo-auditory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Ear.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b8/Ear.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The organ of hearing and of equilibrium. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000330", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/ear"}
property_value: UBPROP:0000003 "Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000330", ontology="VHOG", source="DOI:10.1002/dvdy.20207 Boekhoff-Falk G, Hearing in Drosophila: Development of Johnston's organ and emerging parallels to vertebrate ear development. Developmental Dynamics (2005)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "auricular" xsd:string
@@ -178623,7 +178493,7 @@ relationship: in_lateral_side_of UBERON:0000033 ! head
relationship: never_in_taxon NCBITaxon:9709 {source="Wikipedia"}
relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of UBERON:0001690 ! ear
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray907.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray907.png" xsd:anyURI
property_value: UBPROP:0000001 "The external part of the organ, which consists of an outer portion (external auditory meatus) which leads to the tympanum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000311", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Some species, like Amolops tormotus (Feng et al. 2006), have a cavity in front of the tympanic membrane which is considered to be an ear canal and thus an outer ear. (...) The ancestral lineage of amphibians separated from the mammalian lineage, approximately 350 million years ago, in the paleozoic era. Many of the important developments in the auditory systems emerged after the ancestral paths separated (Manley and Clack 2003). This implies that shared features, like the tympanic middle ear, developed independently in different vertebrate lineages.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000311", ontology="VHOG", source="DOI:10.1007/s00359-008-0327-1 Schoffelen RLM, Segenhout JM, Van Dijk P, Mechanics of the exceptional anuran ear. Journal of Comparative Physiology A (2008)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in XAO this includes and is only the tympanum" xsd:string {external_ontology="XAO"}
@@ -178655,7 +178525,7 @@ xref: Wikipedia:Petrous_part_of_the_temporal_bone
is_a: UBERON:0005913 ! zone of bone organ
relationship: part_of UBERON:0001678 ! temporal bone
relationship: part_of UBERON:0002517 {source="FMA"} ! basicranium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray137.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray137.png" xsd:anyURI
property_value: UBPROP:0000001 "The petrosal bone arises from the two otic bones on the lateral wall of the chondrocranium and encases the inner ear of mammals. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Grande_L, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF, p.258, see_Liem_KF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001553", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "derivative of prootic and opisthotic" xsd:string
@@ -178739,7 +178609,7 @@ relationship: develops_from UBERON:0009124 {source="EHDAA2:0004623", source="ZFA
relationship: develops_from UBERON:0010258 {source="EHDAA2:0004623"} ! mesenchyme from rhombencephalic neural crest
relationship: develops_from UBERON:0012175 {source="EHDAA2:0000491"} ! acoustico-facial VII-VIII ganglion complex
relationship: extends_fibers_into UBERON:0001647 ! facial nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray789.png" xsd:anyURI
property_value: editor_note "resolve facial VII vs geniculate (see EHDAA2)" xsd:string
property_value: UBPROP:0000003 "These (the epibranchial placodes) are focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches in all vertebrates, and they produce the neuroblasts which migrate and condense to form the distal cranial ganglia: the geniculate, petrosal and nodose ganglia. (...) The one substantial difference between the vertebrate pharyngeal arches and those of the protochordates is the presence of the epibranchial placodes but the evolution of these structures was undoubtedly driven by the endoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000707", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"}
@@ -178807,6 +178677,40 @@ property_value: UBPROP:0000010 "It includes the following bones: Ethmoid bone, F
property_value: UBPROP:0000011 "The cartilaginous parts of the neurocranium undergo endochondral ossification in most species; ossification has been lost in cartilaginous fishes, but the cartilaginous condition of the skull of lampreys is considered to be primitive (Kardong, 1995)[PMID:11523816]. The neurocranium arises from paraxial mesoderm in the head (first five somites and the unsegmented somitomeres rostral to the first somite) and from ectoderm via the neural crest. In Chondrichthyes and other cartilaginous vertebrates this portion of the cranium does not ossify; it is not replaced via endochondral ossification[WP]." xsd:string {source="WP"}
property_value: UBPROP:0000012 "It seems MA uses 'neurocranium' as a synonym for chondrocranium. Note there are currently some structures part of both viscero and neurocranium - ethmoid, zyogomatic, ..." xsd:string {external_ontology="MA"}
+[Term]
+id: UBERON:0001705
+name: nail
+namespace: uberon
+def: "A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]." [https://github.com/obophenotype/uberon/issues/120, Wikipedia:Nail_(anatomy)]
+comment: The nails of humans and the claws are moth are highly similar. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse [PMC3579226]
+subset: efo_slim
+subset: pheno_slim
+subset: uberon_slim
+synonym: "claw" NARROW SENSU [Wikipedia:Claw]
+synonym: "nail/claw" EXACT [http://orcid.org/0000-0002-6601-2165]
+synonym: "talon" RELATED []
+xref: BTO:0001719
+xref: CALOHA:TS-2034
+xref: EFO:0000956
+xref: EMAPA:35580
+xref: EV:0100159
+xref: FMA:54326
+xref: GAID:1320
+xref: galen:Nail
+xref: MA:0002703
+xref: MAT:0000158
+xref: MESH:D009262
+xref: MIAA:0000158
+xref: NCIT:C33156
+xref: SCTID:72651009
+xref: UMLS:C0027342 {source="ncithesaurus:Nail"}
+xref: VHOG:0001361
+xref: Wikipedia:Nail_(anatomy)
+is_a: UBERON:0009564 ! distal limb integumentary appendage
+relationship: composed_primarily_of GO:0045095 ! keratin filament
+property_value: IAO:0000232 "Use this class for both the nails of primates and the homologous claws of mammals such as mouse." xsd:string
+property_value: UBPROP:0000008 "A primate's nail consists of the unguis alone; the subunguis has disappeared" xsd:string
+
[Term]
id: UBERON:0001707
name: nasal cavity
@@ -178847,7 +178751,7 @@ xref: ZFA:0000130
is_a: UBERON:0002553 ! anatomical cavity
relationship: develops_from UBERON:0005870 ! olfactory pit
relationship: part_of UBERON:0015788 {source="cjm"} ! olfactory apparatus chamber
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
property_value: editor_note "define the boundaries of this cavity for a variety of species and check that parthood relations are not too strong." xsd:string
property_value: UBPROP:0000001 "a large air filled space above and behind the nose in the middle of the face[WP][Wikipedia:Nasal_cavity]." xsd:string {source="Wikipedia:Nasal_cavity"}
property_value: UBPROP:0000001 "Saclike space internal to the nasal capsule lined by respiratory and sensory epithelium and glandular tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000314", ontology="AAO", source="AAO:LAP"}
@@ -178931,7 +178835,7 @@ disjoint_from: UBERON:0001710 ! lower jaw region
relationship: has_skeleton UBERON:0003277 ! skeleton of upper jaw
relationship: part_of UBERON:0004089 ! midface
relationship: part_of UBERON:0011595 ! jaw region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray189.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001710
property_value: UBPROP:0000001 "Superior maxillary arch located on the anterior and lateral sides of the skull.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000620", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000454", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"}
@@ -178966,7 +178870,7 @@ intersection_of: has_skeleton UBERON:0003278 ! skeleton of lower jaw
relationship: develops_from UBERON:0005867 {source="Wikipedia:Mandibular_prominence"} ! mandibular prominence
relationship: has_skeleton UBERON:0003278 ! skeleton of lower jaw
relationship: part_of UBERON:0011595 ! jaw region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001709
property_value: UBPROP:0000001 "Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000272", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000453", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001)", source="http://bgee.unil.ch/"}
@@ -179003,7 +178907,7 @@ relationship: capable_of GO:0060082 ! eye blink reflex
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 {source="multiple"} ! camera-type eye
relationship: protects UBERON:0010409 ! ocular surface region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI
property_value: UBPROP:0000007 "blepharic" xsd:string
property_value: UBPROP:0000007 "palpebral" xsd:string
property_value: UBPROP:0000008 "In humans the upper and lower eyelid consists of the following layers, starting anteriorly: (1) skin, (2) a layer of subcutaneous connective tissue, (3) a layer of striated muscle fibres of the orbicularis muscle, (4) a layer of submuscular connective tissue, (5) a fibrous layer, including the tarsal plates, (6) a layer of smooth muscle, (7) the palpebral conjunctiva." xsd:string
@@ -179085,7 +178989,7 @@ intersection_of: part_of UBERON:0002610 ! cochlear nuclear complex
relationship: contributes_to_morphology_of UBERON:0002298 ! brainstem
relationship: extends_fibers_into UBERON:0004727 ! cochlear nerve
relationship: part_of UBERON:0002610 ! cochlear nuclear complex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI
[Term]
id: UBERON:0001723
@@ -179131,7 +179035,7 @@ relationship: has_developmental_contribution_from UBERON:0006757 {source="Wikipe
relationship: immediate_transformation_of UBERON:0010056 {evidence="definitional"} ! future tongue
relationship: part_of UBERON:0000165 {source="BTO", source="EHDAA2", source="FMA", source="ZFA"} ! mouth
relationship: part_of UBERON:0001033 {source="MA"} ! gustatory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a6/Tongue.agr.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a6/Tongue.agr.jpg" xsd:anyURI
property_value: editor_note "in MA the tongue is part of the oral region, which in uberon is treated as the oral opening. consider revising oral opening - oral region equivalence." xsd:string
property_value: UBPROP:0000001 "A mobile mass of muscular tissue that is covered with mucous membrane, occupies much of the cavity of the mouth, forms part of its floor, bears the organ of taste, and assists in chewing and swallowing. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000419", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/tongue"}
property_value: UBPROP:0000001 "Muscular organ in the floor of the mouth.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"}
@@ -179213,7 +179117,7 @@ relationship: contributes_to_morphology_of UBERON:0001033 ! gustatory system
relationship: develops_from UBERON:0007690 {source="http://dev.biologists.org/content/128/22/4573.full"} ! early pharyngeal endoderm
relationship: has_part CL:0000209 {source="FMA"} ! taste receptor cell
relationship: part_of UBERON:0002926 {source="NIF"} ! gustatory epithelium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5a/Gray1018.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5a/Gray1018.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002467 {source="http://periowiki.wikispot.org/Taste_bud_histology"}
property_value: UBPROP:0000001 "A chemoreceptive organ.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010573", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "One of a number of receptor cell nests located in the epithelium of the papillae of the tongue and in the soft palate, epiglottis, and pharynx that mediate the sense of taste. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000130", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/taste+bud"}
@@ -179253,7 +179157,7 @@ is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: contributes_to_morphology_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001557 ! upper respiratory tract
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Illu_pharynx.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The uppermost of the three regions of the throat (pharynx), situated behind the nasal cavity and extending from the posterior nares to the level above the soft palate. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000375", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/nasopharynx"}
property_value: UBPROP:0000007 "nasopharyngeal" xsd:string
property_value: UBPROP:0000008 "In humans - in front it communicates through the choanae with the nasal cavities. On its lateral wall is the pharyngeal ostium of the auditory tube, somewhat triangular in shape, and bounded behind by a firm prominence, the torus tubarius or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane" xsd:string
@@ -179338,7 +179242,7 @@ is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system
relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium
relationship: innervated_by UBERON:0003716 ! recurrent laryngeal nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8a/Larynx_external_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8a/Larynx_external_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-larynx.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-larynx.glb" xsd:string
property_value: UBPROP:0000001 "An anatomical cluster consisting of the epiglottus, the arytenoid cartilages, the thyroid cartilage, the cricoid cartilage and the muscles, membranes, and ligaments connecting them, and also of the mucosal covering these structures.[FEED]" xsd:string {date_retrieved="2012-07-02", ontology="FEED", url="http://www.feedexp.org"}
@@ -179439,7 +179343,7 @@ intersection_of: has_part UBERON:0010754 ! germinal center
relationship: contains_process GO:0042100 ! B cell proliferation
relationship: develops_from UBERON:0010422 ! primary nodular lymphoid tissue
relationship: has_part UBERON:0010754 ! germinal center
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Keimzentrum.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Keimzentrum.jpg" xsd:anyURI
[Term]
id: UBERON:0001746
@@ -179550,7 +179454,7 @@ relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external
relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: part_of UBERON:0035639 {source="HPO:pr"} ! ocular adnexa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
property_value: editor_note "TODO - resolve canaliculus vs tear duct vs lacrimal vs nasolacrimal" xsd:string
property_value: UBPROP:0000012 "this is an eye appendage in ncit, along with eyelid and eyebrow. in MA, part of eye surface part_of eye" xsd:string {external_ontology="ncit"}
@@ -179622,7 +179526,7 @@ relationship: develops_from UBERON:0011588 {source="VSAO"} ! pre-enamel
relationship: never_in_taxon NCBITaxon:9359 {source="PMID:19730686"}
relationship: never_in_taxon NCBITaxon:9816 {source="PMID:19730686"}
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Enamelorgan11-17-05.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Enamelorgan11-17-05.jpg" xsd:anyURI
property_value: editor_note "current classification under substance of tooth may be turned into taxon GCI (e.g. sharks have enamel in dermal denticles)" xsd:string
property_value: UBPROP:0000001 "Skeletal tissue that consists of an avascular, noncollagenous, hypermineralized matrix that is deposited by ameloblasts that are excluded from the matrix. Enamel develops from organic pre-enamel tissue that is replaced by a largely inorganic matrix.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000065", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000012 "part_of tooth enamel organ in MA" xsd:string {external_ontology="MA"}
@@ -179652,7 +179556,7 @@ xref: Wikipedia:Cementum
xref: XAO:0004196
is_a: UBERON:0010365 {source="VSAO"} ! odontoid tissue
relationship: has_developmental_contribution_from UBERON:0008969 {source="PMID:19767574", source="Wikipedia"} ! dental follicle
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000062", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Substance of tooth produced by cementoblasts; surrounds the dentine of the root of the tooth[FMA:55630]." xsd:string {source="FMA:55630"}
property_value: UBPROP:0000008 "Cementum, the supporting tissue that anchors mammalian and crocodylian teeth into their sockets, differs among species and can have features of dentine, of bone, and of calcified cartilage, as well as unique features. Cementum is deposited by cementoblasts onto existing dentine. As in bone and dentine, cementoblasts produce an organic matrix, the main constituent of which is collagen type I (Bosshardt, 2005), but cementum, dentine, and bone also share a number of important noncollagenous matrix components such as osteopontin, osteocalcin, bone sialoprotein, a2-HS- glycoprotein, dentine matrix protein, dentine sialoprotein, and den- tine phosphoprotein (McKee et al., 1996; Bosshardt, 2005). it has been argued that in all rodents and ruminants, cementum is a form of calcified cartilage[H&W]" xsd:string
@@ -179686,7 +179590,7 @@ is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue
relationship: develops_from UBERON:0001763 {source="ZFA"} ! odontogenic papilla
relationship: has_part CL:0000060 ! odontoblast
relationship: part_of UBERON:0001091 ! calcareous tooth
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg" xsd:anyURI
property_value: UBPROP:0000001 "Material in the center of the dentine of the mature tooth. In secondary teeth the pulp contains blood vessels and odontoblast.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005141", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The oral cavity of vertebrates is generally thought to arise as an ectodermal invagination. Consistent with this, oral teeth are proposed to arise exclusively from ectoderm, contributing to tooth enamel epithelium, and from neural crest derived mesenchyme, contributing to dentin and pulp (reference 1); Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001469", ontology="VHOG", source="DOI:10.1038/nature07304 Soukup V, Epperlein HH, Horacek I, Cerny R, Dual epithelial origin of vertebrate oral teeth. Nature (2008), DOI:10.1186/1471-2148-11-307 The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula. BMC Evolutionary Biology (2011)", source="http://bgee.unil.ch/"}
@@ -179782,7 +179686,7 @@ is_a: UBERON:0000479 {source="cjm"} ! tissue
relationship: adjacent_to UBERON:0001091 ! calcareous tooth
relationship: has_part CL:0002166 {source="FMA"} ! epithelial cell of Malassez
relationship: part_of UBERON:0003672 {source="cjm"} ! dentition
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI
property_value: UBPROP:0000012 "FMA treats periodontium and periodontal ligament as the same" xsd:string {external_ontology="FMA"}
[Term]
@@ -179842,7 +179746,7 @@ relationship: extends_fibers_into UBERON:0011775 ! vagus nerve nucleus
relationship: has_developmental_contribution_from UBERON:0005239 {notes="motor", source="Wikipedia"} ! basal plate metencephalon
relationship: part_of UBERON:0001033 ! gustatory system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Gray791.png" xsd:anyURI
property_value: UBPROP:0000001 "Nerve consisting of branchiomotor and visceral efferent fibers which branch and innervate the smooth muscles and glands of the heart, lungs, esophagus, and stomach as well as some throat muscles. Sensory fibers supply mucosa of the mouth and pharynx.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010475", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...) (reference 1); Phylogenetically, the cranial nerves are thought to have evolved from dorsal and ventral nerves of a few anterior spinal nerves that became incorporated into the braincase. Dorsal and ventral nerves fuse in the trunk but not in the head, and they produce two series: dorsal cranial nerves (V, VII, IX, and X) and ventral cranial nerves (III, IV, VI, and XIII) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000737", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625", source="http://bgee.unil.ch/"}
@@ -179882,7 +179786,7 @@ relationship: develops_from UBERON:0003856 {source="ZFA"} ! uncondensed odontoge
relationship: immediately_deep_to UBERON:0005176 ! tooth enamel organ
relationship: located_in UBERON:0001828 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA-implied"} ! gingiva
relationship: part_of UBERON:0008281 ! tooth bud
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray1011.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray1011.png" xsd:anyURI
property_value: UBPROP:0000001 "Cell condensation that is a well-defined population of densely organized mesenchymal cells that aggregates adjacent to an epithelium.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000025", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Tissue of the developing tooth. It is composed of pre-odontoblast and undiffentiated mesnchyme cells and connects to the basal lamina.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005140", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "Teeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001465", ontology="VHOG", source="DOI:10.1186/1471-2148-11-307 The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula. BMC Evolutionary Biology (2011)", source="http://bgee.unil.ch/"}
@@ -179920,7 +179824,7 @@ intersection_of: UBERON:0000058 ! duct
intersection_of: part_of UBERON:0001911 ! mammary gland
relationship: channel_for UBERON:0001913 ! milk
relationship: channels_into UBERON:0002030 ! nipple
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg" xsd:anyURI
[Term]
id: UBERON:0001766
@@ -179951,7 +179855,7 @@ xref: Wikipedia:Anterior_chamber_of_eyeball
is_a: UBERON:0006311 {source="FMA"} ! chamber of eyeball
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001431", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/anterior+chamber"}
property_value: UBPROP:0000012 "space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball" xsd:string {external_ontology="EHDAA2"}
@@ -179986,7 +179890,7 @@ relationship: has_part UBERON:0001775 ! ciliary body
relationship: has_part UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
relationship: present_in_taxon NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI
property_value: editor_note "TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus" xsd:string
property_value: UBPROP:0000007 "uveal" xsd:string
@@ -180100,7 +180004,7 @@ relationship: bounding_layer_of UBERON:0000964 ! cornea
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002187", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"}
property_value: UBPROP:0000008 "In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei" xsd:string
property_value: UBPROP:0000008 "In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" xsd:string
@@ -180139,7 +180043,7 @@ relationship: has_part CL:0000347 {source="ZFA"} ! scleral cell
relationship: has_quality PATO:0000963 ! opaque
relationship: part_of UBERON:0012430 {source="FMA"} ! tunica fibrosa of eyeball
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]." xsd:string {source="Wikipedia:Sclera"}
property_value: UBPROP:0000001 "The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001274", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sclera"}
property_value: UBPROP:0000007 "scleral" xsd:string
@@ -180215,7 +180119,7 @@ relationship: has_part UBERON:0001605 ! ciliary muscle
relationship: has_part UBERON:0010427 ! ciliary processes
relationship: part_of UBERON:0011892 ! anterior uvea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000102", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
[Term]
@@ -180260,7 +180164,7 @@ relationship: overlaps UBERON:0001802 {source="Wikipedia"} ! posterior segment o
relationship: part_of UBERON:0001768 {source="MA"} ! uvea
relationship: part_of UBERON:0019207 ! chorioretinal region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: editor_note "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" xsd:string
property_value: UBPROP:0000007 "choroidal" xsd:string
property_value: UBPROP:0000012 "MP treats posterior uvea and optic choroid as distinct" xsd:string {external_ontology="MP"}
@@ -180299,7 +180203,7 @@ relationship: adjacent_to UBERON:0004370 ! anterior limiting lamina of cornea
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0007213 {inferred_by="cjm", source="ISBN:0781772214", source="Wikipedia"} ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0000964 ! cornea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"}
property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"}
property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"}
@@ -180352,7 +180256,7 @@ intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0001769 ! iris
relationship: contributes_to_morphology_of UBERON:0001769 ! iris
relationship: part_of UBERON:0001769 ! iris
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
[Term]
id: UBERON:0001780
@@ -180394,7 +180298,7 @@ intersection_of: UBERON:0001021 ! nerve
intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord
relationship: extends_fibers_into UBERON:0002240 ! spinal cord
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "Any of the paired nerves emerging from the spinal cord, each attached to the cord by two roots: ventral and dorsal, and passing out between the vertebrae. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000824", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/spinal+nerve"}
[Term]
@@ -180475,7 +180379,7 @@ relationship: adjacent_to UBERON:0003902 ! retinal neural layer
relationship: has_part GO:0048770 ! pigment granule
relationship: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000144", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The monolayer of pigmented epithelium covering the neural retina.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011096", ontology="AAO", source="ZFA:0000144"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000536", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -180523,8 +180427,8 @@ intersection_of: extends_fibers_into UBERON:0000955 ! brain
relationship: anterior_to UBERON:0001780 ! spinal nerve
relationship: has_developmental_contribution_from UBERON:0003099 ! cranial neural crest
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/18/Brain_human_normal_inferior_view_with_labels_en-2.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/84/Brain_human_normal_inferior_view_with_labels_en.svg" xsd:anyURI
property_value: editor_note "classified as neural tree organ, not nerve in FMA. CN II poses a challenge here as it is not strictly a nerve, yet is expected to be classified under CN." xsd:string
property_value: UBPROP:0000001 "Twelve pairs of cranial nerves exit/enter the cranium through openings in the skull. The nerves contain efferent axons with motor and glandular functions, as well as afferent axons from cranial ganglia with sensory functions. The nerves are numbered in a rostral to caudal sequence, with the exception of the lateral line nerves.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000641", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (...) (5) cranial nerves (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000279", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"}
@@ -180561,7 +180465,7 @@ relationship: has_part CHEBI:28838
relationship: has_part CL:0000573 ! retinal cone cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0000053 ! macula lutea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "A small pit in the center of the macula lutea, the area of clearest vision, where the retinal layers are spread aside, and light falls directly on the cones. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001572", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/fovea"}
property_value: UBPROP:0000003 "Definition of fovea centralis should be considered here as 'an area centralis at the visual axis' (reference 1). There is an uncertaincy of the relation, because: 1.-The fovea first appeared in evolution in the temporal retina of fishes. Then, in birds, the nasal fovea and bifoveal system with nasal and temporal foveas developed. The fovea disappeared in primitive mammals, and reappeared in primates. A residue of the fovea is conserved in the visual streak, and the disappearance and reappearance of the fovea, in primitive mammals and primates respectively, correlates with degeneration and restoration of cone pigment genes in photoreceptors (reference 2). 2.-Many retinal features (foveas, trichromacy, midget pathways and associated cell types) appear specific to primates. This has led to investigations in parallel with other mammalian models such as cat or rabbit. Correlation of the results often proves to be difficult, since an evolutionary scenario with transitions between the mammalian models is largely lacking (reference 3).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001572", ontology="VHOG", source="DOI:10.1017/S095252380623342X Ahnelt PK, Schubert C, Kübber-Heiss A, Schiviz A, Anger E, Independent variation of retinal S and M cone photoreceptor topographies: A survey of four families of mammals. Visual neuroscience (2006), http://www.ncbi.nlm.nih.gov/pubmed/11193946 Azuma N, Molecular cell biology on morphogenesis of the fovea and evolution of the central vision. Nihon Ganka Gakkai Zasshi (2000), DOI:10.1016/S1350-9462(00)00012-4 Ahnelt PK, Kolb H, The mammalian photoreceptor mosaic-adaptive design. Progress in Retinal and Eye Research (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "foveal" xsd:string
@@ -180596,7 +180500,7 @@ is_a: UBERON:0001781 ! layer of retina
relationship: adjacent_to UBERON:0001788 ! outer limiting layer of retina
relationship: has_part CL:0000287 {source="ZFA"} ! eye photoreceptor cell
relationship: part_of UBERON:0003902 ! retinal neural layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "we follow MA and ZFA in subdividing this into inner and outer segments" xsd:string {external_ontology="MA"}
@@ -180795,7 +180699,7 @@ relationship: composed_primarily_of CL:0000740 ! retinal ganglion cell
relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer
relationship: part_of UBERON:0003902 {source="FMA"} ! retinal neural layer
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]." xsd:string {source="Wikipedia:Ganglion_cell_layer"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030]" xsd:string {external_ontology="NIF"}
@@ -180915,7 +180819,7 @@ relationship: has_part GO:0030425 ! dendrite
relationship: overlaps CL:0000740 ! retinal ganglion cell
relationship: overlaps CL:0000748 ! retinal bipolar neuron
relationship: part_of UBERON:0003902 ! retinal neural layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells[GO][GO:0010842]." xsd:string {source="GO:0010842"}
property_value: UBPROP:0000001 "The layer within the retina where the bipolar cells synapse with the dendrites of the ganglion cells.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001329", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001168", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -180950,7 +180854,7 @@ is_a: UBERON:0006312 ! ocular refractive media
is_a: UBERON:0006314 ! bodily fluid
relationship: contributes_to_morphology_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 {notes="FMA def states A and P", notes="located_in in EHDAA2", source="VHOG"} ! anterior chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aqueous+humour"}
property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." xsd:string {external_ontology="FMA"}
@@ -180988,7 +180892,7 @@ is_a: UBERON:0006312 ! ocular refractive media
relationship: has_quality PATO:0000964 ! transparent
relationship: located_in UBERON:0005606 ! hyaloid cavity
relationship: part_of UBERON:0001798 ! vitreous body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
[Term]
id: UBERON:0001798
@@ -181010,7 +180914,7 @@ is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue
relationship: composed_primarily_of UBERON:0001797 ! vitreous humor
relationship: has_developmental_contribution_from UBERON:0002346 {notes="neural ectoderm of optic cup", source="ISBN:0781772214"} ! neurectoderm
relationship: part_of UBERON:0001799 ! vitreous chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: editor_note "distinciton between body and humor requires more work. These may be merged in future. Note that FMA includes the hyaloid canal as part of the vitreous body" xsd:string
[Term]
@@ -181087,7 +180991,7 @@ disjoint_from: UBERON:0001802 {source="lexical"} ! posterior segment of eyeball
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: in_anterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye
relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001802 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
[Term]
@@ -181116,7 +181020,7 @@ is_a: UBERON:0000063 ! organ subunit
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: in_posterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye
relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
[Term]
id: UBERON:0001803
@@ -181183,7 +181087,7 @@ relationship: develops_from UBERON:0005614 {source="EHDAA2"} ! lens anterior epi
relationship: has_part CHEBI:35722
relationship: has_part GO:0005587 ! collagen type IV trimer
relationship: has_quality PATO:0000964 ! transparent
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
property_value: UBPROP:0000001 "The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000550", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000550", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000010 "synthesized by the lens epithelium and its main components are Type IV collagen and sulfated glycosaminoglycans (GAGs). [Wikipedia:Capsule_of_lens" xsd:string
@@ -181215,7 +181119,7 @@ intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0002410 ! autonomic nervous system
relationship: extends_fibers_into UBERON:0034728 ! autonomic nerve
relationship: part_of UBERON:0002410 ! autonomic nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
[Term]
id: UBERON:0001806
@@ -181249,7 +181153,7 @@ relationship: contributes_to_morphology_of UBERON:0000013 ! sympathetic nervous
relationship: develops_from UBERON:0003083 {source="DOI:10.1101/gr.157586.113", source="ISBN:0073040584"} ! trunk neural crest
relationship: extends_fibers_into UBERON:0034729 ! sympathetic nerve
relationship: part_of UBERON:0000013 ! sympathetic nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
[Term]
id: UBERON:0001807
@@ -181281,7 +181185,7 @@ is_a: UBERON:0007134 {source="ZFA"} ! trunk ganglion
intersection_of: UBERON:0000045 ! ganglion
intersection_of: part_of UBERON:0000407 ! sympathetic trunk
relationship: part_of UBERON:0000407 ! sympathetic trunk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray847.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray847.png" xsd:anyURI
property_value: UBPROP:0000202 FMA:80128
[Term]
@@ -181310,7 +181214,7 @@ intersection_of: part_of UBERON:0000011 ! parasympathetic nervous system
relationship: contributes_to_morphology_of UBERON:0000011 ! parasympathetic nervous system
relationship: extends_fibers_into UBERON:0004293 ! parasympathetic nerve
relationship: part_of UBERON:0000011 ! parasympathetic nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
[Term]
id: UBERON:0001809
@@ -181393,7 +181297,7 @@ relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external
relationship: part_of UBERON:0005908 {source="cjm"} ! conjunctival sac
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
property_value: UBPROP:0000007 "conjunctival" xsd:string
[Term]
@@ -181444,8 +181348,8 @@ is_a: UBERON:0000122 ! neuron projection bundle
is_a: UBERON:0001813 ! spinal nerve plexus
relationship: innervates UBERON:0002102 ! forelimb
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray808.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c9/Brachial_plexus_color.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3a/Gray808.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c9/Brachial_plexus_color.svg" xsd:anyURI
property_value: editor_note "check superclass - nerve vs collection of fibers vs junction; note that FMA also has 'brachial autonomic nerve plexus'" xsd:string
property_value: UBPROP:0000001 "A nerve plexus originating from the anterior branches of the last four cervical and the first thoracic spinal nerves, giving off many of the principal nerves of the shoulder, chest, and arms. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000372", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/brachial+plexus"}
property_value: UBPROP:0000003 "To reach the muscles, dermatomes, and other structures of the limbs, some of the neurons in the spinal nerves come together in the plexus at the base of the limb. Such plexuses occur in all gnathostomes, and they reach their highest complexity among mammals and birds in which the cervical plexus supplies many ventral neck muscles, the brachial plexus supplies the pectoral appendage, a lumbosacral plexus supplies the pelvic appendage, and a coccygeal plexus supplies some of the pelvic muscles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000372", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.436", source="http://bgee.unil.ch/"}
@@ -181475,7 +181379,7 @@ xref: Wikipedia:Lumbosacral_plexus
is_a: UBERON:0000122 ! neuron projection bundle
is_a: UBERON:0001813 ! spinal nerve plexus
relationship: innervates UBERON:0002103 ! hindlimb
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Gray822.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Gray822.png" xsd:anyURI
[Term]
id: UBERON:0001816
@@ -181533,7 +181437,7 @@ relationship: contributes_to_morphology_of UBERON:0001750 ! lacrimal apparatus
relationship: develops_from UBERON:0022284 ! lacrimal gland bud
relationship: never_in_taxon NCBITaxon:8570 {source="PMID:7559104"}
relationship: part_of UBERON:0001750 ! lacrimal apparatus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
property_value: UBPROP:0000001 "Lobular organ the parenchyma of which consists of glandular acini which communicate the lacrimal sac. Examples: There only two instances, right lacrimal and left lacrimal glands." xsd:string {source="FMA:59101"}
property_value: UBPROP:0000001 "The preorbital gland is a paired exocrine gland found in many species of hoofed animals, which is homologous to the lacrimal gland found in humans. These glands are trenchlike slits of dark blue to black, nearly bare skin extending from the medial canthus of each eye. They are lined by a combination of sebaceous and sudoriferous glands, and they produce secretions which contain pheromones and other semiochemical compounds. Ungulates frequently deposit these secretions on twigs and grass as a means of communication with other animals. The preorbital gland serves different roles in different species. Pheromone-containing secretions from the preorbital gland may serve to establish an animal's dominance (especially in preparation for breeding), mark its territory, or simply to produce a pleasurable sensation to the animal. Because of its critical role in scent marking, the preorbital gland is usually considered as a type of scent gland. A further function of these glands may be to produce antimicrobial compounds against skin pathogens. Antimicrobial compounds found in these glands may be biosynthesized by the animal itself, or by microorganisms that live in these glands[Wikipedia:Preorbital_gland]." xsd:string {source="Wikipedia:Preorbital_gland"}
property_value: UBPROP:0000006 "https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern" xsd:anyURI
@@ -181572,7 +181476,7 @@ relationship: develops_from UBERON:0005089 {evidence="definitional"} ! sweat gla
relationship: has_quality PATO:0002299 {notes="coiled tubular", source="Wikipedia:Tubular_gland"} ! tubular
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: produces UBERON:0001089 ! sweat
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
property_value: editor_note "TODO - check if all sweat glands are epidermal - see EMAPA:29743" xsd:string
property_value: UBPROP:0000001 "A gland that secretes sweat, found in the dermis or subcutaneous tissue, opening by a duct on the body surface. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001467", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sweat+gland"}
property_value: UBPROP:0000003 "Sweat glands (also called sudoriferous glands) are unique to mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001467", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.101", source="http://bgee.unil.ch/"}
@@ -181611,7 +181515,7 @@ relationship: only_in_taxon NCBITaxon:40674 {source="VHOG"} ! Mammalia
relationship: part_of UBERON:0011932 ! pilosebaceous unit
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: produces UBERON:0001866 ! sebum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/49/HairFollicle.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/49/HairFollicle.png" xsd:anyURI
property_value: IAO:0000232 "sebaceous glands are also found in glabrous areas of eyelids, nose, penis, labia minora and nipples, and do not always secrete into hair follices. This causes some confusion in classification. In addition some structures, such as preputial glands are sometimes called 'modified' sebaceous glands, implying a non-subclass relationship. we follow MP and MA in keeping this class generic and creating a distinct subclass for sebaceuous glands of the skin. The FMA class may be better placed under this subclass." xsd:string
property_value: UBPROP:0000001 "Any of the numerous holocrine glands in the dermis that empty into a hair follicle and produce and secrete sebum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001468", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sebaceous+gland"}
property_value: UBPROP:0000003 "Sebaceous glands are also limited to mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001468", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.102", source="http://bgee.unil.ch/"}
@@ -181640,7 +181544,7 @@ intersection_of: UBERON:0007844 ! cartilage element
intersection_of: part_of UBERON:0000004 ! nose
relationship: location_of UBERON:0000402 ! nasal vestibule
relationship: part_of UBERON:0000004 ! nose
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray852.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e1/Gray852.png" xsd:anyURI
[Term]
id: UBERON:0001824
@@ -181760,7 +181664,7 @@ relationship: adjacent_to UBERON:0008266 ! periodontal ligament
relationship: continuous_with UBERON:0003729 {source="ISBN:0013002015"} ! mouth mucosa
relationship: part_of UBERON:0003729 {source="Carranza"} ! mouth mucosa
relationship: part_of UBERON:0011595 ! jaw region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2e/Tooth_Section.svg" xsd:anyURI
property_value: editor_note "FMA has a 3-level breakdown of jaws into: region, jaw (skeleton+gums), skeleton." xsd:string
property_value: UBPROP:0000007 "gingival" xsd:string
@@ -181794,8 +181698,8 @@ relationship: contributes_to_morphology_of UBERON:0000165 ! mouth
relationship: never_in_taxon NCBITaxon:8782 ! Aves
relationship: part_of UBERON:0000165 {source="BTO", source="FMA-implicit", source="VHOG", source="ZFA"} ! mouth
relationship: surrounds UBERON:0000166 {source="cjm"} ! oral opening
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007006", ontology="TAO", source="ZFIN:curator", source="http//:www.medterms.com/script/main/art.asp?articlekey=9458"}
property_value: UBPROP:0000007 "labial" xsd:string
@@ -181823,7 +181727,7 @@ intersection_of: UBERON:0001833 ! lip
intersection_of: part_of UBERON:0001709 ! upper jaw region
relationship: immediate_transformation_of UBERON:0011592 ! future upper lip
relationship: part_of UBERON:0001709 ! upper jaw region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Lip that covers the lower portion of the mouth. [ZFIN:Curator][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001750", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Lip that covers the upper portion of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001970", ontology="TAO", source="TAO:wd"}
@@ -181853,7 +181757,7 @@ intersection_of: UBERON:0001833 ! lip
intersection_of: part_of UBERON:0001710 ! lower jaw region
relationship: develops_from UBERON:0011596 ! future lower lip
relationship: part_of UBERON:0001710 ! lower jaw region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Lip that covers the lower portion of the mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002060", ontology="TAO", source="TAO:wd"}
[Term]
@@ -181941,7 +181845,7 @@ is_a: UBERON:0034921 ! multi organ part structure
relationship: part_of UBERON:0001694 {source="FMA", source="MA"} ! petrous part of temporal bone
relationship: part_of UBERON:0001846 {source="FMA"} ! internal ear
relationship: part_of UBERON:0004681 ! vestibular system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray920.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray920.png" xsd:anyURI
[Term]
id: UBERON:0001840
@@ -181976,7 +181880,7 @@ xref: ZFA:0000431
is_a: UBERON:0000025 {source="GO"} ! tube
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0001849 {source="OG"} ! membranous labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/Balance_Disorder_Illustration_A.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/Balance_Disorder_Illustration_A.png" xsd:anyURI
property_value: UBPROP:0000001 "Fluid-filled toroidal spaces, arranged orthogonally to each other in the ear, that detect angular accelerations. (See Anatomical Atlas entry for semicircular canals by T. Whitfield.)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000431", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. These ducts are sometimes called canals, but technically the term semicircular canal applies to the spaces in the osseus labyrinth in which the semicircular ducts lie.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001144", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.414", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000009 "detects angular acceleration" xsd:string
@@ -182024,8 +181928,8 @@ is_a: UBERON:0034921 ! multi organ part structure
relationship: contributes_to_morphology_of UBERON:0001846 ! internal ear
relationship: has_quality PATO:0000404 {gci_relation="part_of", gci_filler="NCBITaxon:32525", source="Wikipedia"} ! coiled
relationship: part_of UBERON:0001839 {source="FMA", source="VHOG", source="XAO", source="ncit"} ! bony labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg" xsd:anyURI
property_value: UBPROP:0000001 "A spiral-shaped cavity in the petrous portion of the temporal bone of the inner ear, containing the nerve endings essential for hearing and forming one of the divisions of the labyrinth. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000691", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/cochlea"}
property_value: UBPROP:0000003 "Because achieving high sensitivity is generally advantageous for auditory organs, it is not surprising that evidence for cochlear amplification is also seen in nonmammals. Spontaneous otoacoustic emissions (SOAEs) are narrow-band sound signals emitted from the inner ear, and it is generally assumed that their energy derives from the hair-cell molecular motors underlying cochlear amplification. However, all terrestrial vertebrates studied so far (including amphibians) show very similar SOAEs. The most parsimonious explanation for the universality of this phenomena is that some kind of amplifying mechanism is at least as old as land vertebrates themselves.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000691", ontology="VHOG", source="DOI:10.1016/S0959-4388(98)80033-0 Manley GA, Koeppl C, Phylogenetic development of the cochlea and its innervation. Current Opinion in Neurobiology (1998)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "cochlear" xsd:string
@@ -182099,7 +182003,7 @@ xref: ZFA:0000217
is_a: UBERON:0034921 ! multi organ part structure
relationship: develops_from UBERON:0003051 {evidence="definitional"} ! ear vesicle
relationship: part_of UBERON:0001690 ! ear
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI
property_value: UBPROP:0000001 "The auditory (hearing) and vestibular (balance) organ of the fish, equivalent to the inner ear of amniotes. (See Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000217", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The labyrinth, or inner ear, evolved very early in vertebrate history and, with many variations in configuration but none of basic design and function, has been retained by all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000284", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.366", source="http://bgee.unil.ch/"}
@@ -182149,7 +182053,7 @@ is_a: UBERON:0000062 ! organ
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: located_in UBERON:0004637 ! otic capsule
relationship: part_of UBERON:0001846 {source="FMA", source="MA"} ! internal ear
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray924.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray924.png" xsd:anyURI
property_value: UBPROP:0000001 "A system of communicating epithelial sacs and ducts within the bony labyrinth, containing the endolymph. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000729", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/membranous+labyrinth"}
property_value: UBPROP:0000003 "The labyrinth, or inner ear, evolved very early in vertebrate history and, with many variations in configuration but none of basic design and function, has been retained by all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000729", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.366", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "inner ear has parts membranous and osseuous/bony labyrinth. it's not clear where the EMAPA term 'labyrinth' belong, we place them here for now" xsd:string {external_ontology="EMAPA"}
@@ -182265,7 +182169,7 @@ xref: Wikipedia:Saccule
xref: XAO:0000196
xref: ZFA:0000428
is_a: UBERON:0002518 {source="Wikipedia", source="ZFA"} ! otolith organ
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The most ventral chamber of the membranous labyrinth. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-25, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000374", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. (...) In all gnathostomes, the utriculus connects ventrally with a larger sac, called the sacculus (...) .[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000374", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.413-414", source="http://bgee.unil.ch/"}
@@ -182304,7 +182208,7 @@ xref: VHOG:0000507
xref: Wikipedia:Cochlear_duct
is_a: UBERON:0000025 ! tube
relationship: part_of UBERON:0002499 {source="FMA", source="MA"} ! cochlear labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png" xsd:anyURI
property_value: editor_note "TODO - check cochlear duct vs cochlear aqueduct vs scala media" xsd:string
property_value: UBPROP:0000001 "The coiled portion of the membranous labyrinth located inside the cochlea. It contains endolymph. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000507", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/cochlear+duct"}
property_value: UBPROP:0000003 "In gnathostomes, each membranous labyrinth has three semicircular ducts that connect with a chamber known as the utriculus. (...) In all gnathostomes, the utriculus connects ventrally with a larger sac, called the sacculus (...) In most groups of gnathostomes, the caudoventral evagination of the sacculus forms a small lagena, and in some diapsids and mammals the lagena develops into a longer duct. The lagena becomes greatly elongated in therians and coils to form the cochlear duct.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000507", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.413-414", source="http://bgee.unil.ch/"}
@@ -182467,7 +182371,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: in_lateral_side_of UBERON:0000955 ! brain
relationship: in_lateral_side_of UBERON:0001893 {source="FMA-abduced-lr"} ! telencephalon
relationship: part_of UBERON:0001893 ! telencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png" xsd:anyURI
property_value: UBPROP:0000001 "Part of the telencephalon consisting of either of the two smooth, elongated halves of the cerebrum.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010480", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001639", ontology="VHOG", source="DOI:10.1146/annurev.ne.04.030181.001505 Northcutt RG, Evolution of the telencephalon in nonmammals. Ann. Rev. Neurosci. (1981)", source="http://bgee.unil.ch/"}
@@ -182499,7 +182403,7 @@ intersection_of: UBERON:0016529 ! cortex of cerebral lobe
intersection_of: part_of UBERON:0016525 ! frontal lobe
relationship: part_of UBERON:0016525 ! frontal lobe
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray729.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b4/Gray729.png" xsd:anyURI
property_value: UBPROP:0000001 "Anterior portion of the frontal cortex, lying anterior to the central sulcus. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally." xsd:string {source="NLXANAT:20090601"}
[Term]
@@ -182537,7 +182441,7 @@ xref: Wikipedia:Temporal_lobe
is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere
relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/91/Gray730.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/91/Gray730.png" xsd:anyURI
[Term]
id: UBERON:0001872
@@ -182572,7 +182476,7 @@ is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere
relationship: adjacent_to UBERON:0001871 ! temporal lobe
relationship: contributes_to_morphology_of UBERON:0001893 ! telencephalon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray726_parietal_lobe.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray726_parietal_lobe.png" xsd:anyURI
[Term]
id: UBERON:0001873
@@ -182614,7 +182518,7 @@ xref: Wikipedia:Caudate_nucleus
is_a: UBERON:0009663 ! telencephalic nucleus
relationship: contributes_to_morphology_of UBERON:0005383 ! caudate-putamen
relationship: part_of UBERON:0005383 {source="MA"} ! caudate-putamen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Nucleus of brain which is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent[FMA:61833]." xsd:string {source="FMA:61833"}
[Term]
@@ -182652,7 +182556,7 @@ relationship: contributes_to_morphology_of UBERON:0005383 ! caudate-putamen
relationship: part_of UBERON:0001869 {source="FMA"} ! cerebral hemisphere
relationship: part_of UBERON:0005383 ! caudate-putamen
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg" xsd:anyURI
property_value: editor_note "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)" xsd:string
property_value: UBPROP:0000001 "Nucleus of brain which lies ventral to the caudate nucleus and internal capsule and medial to the external capsule. The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease[Wikipedia:Putamen]." xsd:string {source="Wikipedia:Putamen"}
property_value: UBPROP:0000003 "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001456", ontology="VHOG", source="DOI:10.1016/j.cub.2011.05.001 Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S, Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection. Current Biology (2011)", source="http://bgee.unil.ch/"}
@@ -182709,7 +182613,7 @@ is_a: UBERON:0002420 {source="FMA"} ! basal ganglion
is_a: UBERON:0005401 ! cerebral hemisphere gray matter
relationship: part_of UBERON:0000349 {source="FMA"} ! limbic system
relationship: part_of UBERON:0001871 {source="BTO"} ! temporal lobe
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Amyg.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Amyg.png" xsd:anyURI
property_value: UBPROP:0000001 "Subdivision of basal ganglion of telencephalon which is an almond-shaped gray mass in the dorsomedial part of the temporal lobe[FMA:61841]" xsd:string {source="FMA:61841"}
property_value: UBPROP:0000003 "One part of the striatum is called the archistriatum. (...) The archistriatum of fishes consists of several indistinctly segregated nuclei called the amygdaloid (...) complex. Tetrapods retain the structure, and in mammals the corresponding amygdala is a globular mass that tends to be ventral to the other basal nuclei.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001277", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.342", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "amygdalar" xsd:string
@@ -182751,7 +182655,7 @@ relationship: contributes_to_morphology_of UBERON:0001883 ! olfactory tubercle
relationship: part_of UBERON:0001869 ! cerebral hemisphere
relationship: part_of UBERON:0001882 {gci_relation="part_of", gci_filler="NCBITaxon:9443", source="MP"} ! nucleus accumbens
relationship: part_of UBERON:0001883 {gci_relation="part_of", gci_filler="NCBITaxon:9989", source="MP"} ! olfactory tubercle
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Islands_of_Calleja_Rat.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Islands_of_Calleja_Rat.jpg" xsd:anyURI
property_value: UBPROP:0000008 "The islands of Calleja are located within the olfactory tubercle in most species; however, in primates these islands are located within the nucleus accumbens, since the olfactory tubercle is absent or extremely rudimentary in the brains of primates" xsd:string {source="MP:0010010"}
[Term]
@@ -182795,7 +182699,7 @@ relationship: part_of UBERON:0000349 {source="FMA", source="GO"} ! limbic system
relationship: part_of UBERON:0001869 ! cerebral hemisphere
relationship: part_of UBERON:0005403 {source="MA"} ! ventral striatum
relationship: present_in_taxon NCBITaxon:8782 {source="ISBN:0471888893"} ! Aves
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Circuit_du_syst%C3%A8me_de_recompense.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Circuit_du_syst%C3%A8me_de_recompense.jpg" xsd:anyURI
property_value: RO:0002171 UBERON:0001883 {source="ABA"}
property_value: UBPROP:0000001 "a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia[GO][GO:0021768]." xsd:string {source="GO:0021768"}
property_value: UBPROP:0000008 "The ventral striatopallidal complex in birds corresponds closely to its counterpart in mammals, with a nucleus accumbes present in the rostral telenceaphalon. Note that in birds, a region previously called the nucleus accumbens is now recognized as the lateral part of the bed nucleus of stria terminalis.[ISBN:0471888893]" xsd:string
@@ -182829,7 +182733,7 @@ xref: Wikipedia:Olfactory_tubercle
is_a: UBERON:0009663 ! telencephalic nucleus
relationship: contributes_to_morphology_of UBERON:0002894 ! olfactory cortex
relationship: part_of UBERON:0002894 {source="EHDAA2-inferred", source="MA", source="VHOG", source="Wikipedia"} ! olfactory cortex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001882 {source="ABA"}
property_value: RO:0002174 NCBITaxon:9443 {editor_note="check EHDAA2", source="MP"}
property_value: UBPROP:0000001 "The olfactory tubercle is a structure involved in Olfaction. It is present in humans, but much smaller than it is in some other animals. It is a frequent subject of research." xsd:string {source="Wikipedia:Olfactory_tubercle"}
@@ -182865,7 +182769,7 @@ intersection_of: innervates UBERON:0001103 ! diaphragm
relationship: branching_part_of UBERON:0000962 ! nerve of cervical vertebra
relationship: innervates UBERON:0001103 ! diaphragm
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Gray806.png" xsd:anyURI
property_value: UBPROP:0000001 "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000728", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/phrenic+nerve"}
[Term]
@@ -182908,7 +182812,7 @@ xref: Wikipedia:Dentate_gyrus
is_a: UBERON:0000200 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! gyrus
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0002421 {source="MA"} ! hippocampal formation
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/HippocampalRegions.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ab/HippocampalRegions.jpg" xsd:anyURI
property_value: RO:0002171 UBERON:0001954 {source="ABA"}
property_value: RO:0002171 UBERON:0002601 {source="ABA"}
property_value: UBPROP:0000001 "The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus[GO][GO:0021542]." xsd:string {source="GO:0021542"}
@@ -182956,7 +182860,7 @@ is_a: UBERON:0036303 ! vasculature of central nervous system
relationship: contributes_to_morphology_of UBERON:0003947 ! brain ventricle/choroid plexus
relationship: part_of UBERON:0004086 ! brain ventricle
relationship: part_of UBERON:0005283 ! tela choroidea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray708.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray708.svg" xsd:anyURI
property_value: editor_note "TODO - check relationship to ventricle. Check subclass - ZFA says vasculature. Note that FMA:61934 (choroid plexus of cerebral hemisphere) has exact synonym 'choroid plexus' but it is not clear that this belongs here, as the fourth ventricle is not in the cerebral hemisphere" xsd:string
property_value: UBPROP:0000001 "A tuft of capillaries that project into the ventricles of the brain and secretes cerebral spinal fluid. The choroid plexus is covered by a cuboidal epithelium which maintains the integrity of the blood-brain barrier.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001443", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Fringe of the tela choroidea of the brain ventricles[MP]" xsd:string {source="MP:0000820"}
@@ -182998,7 +182902,7 @@ is_a: UBERON:0034730 ! olfactory tract linking bulb to ipsilateral dorsal telenc
intersection_of: UBERON:0002265 ! olfactory tract
intersection_of: overlaps UBERON:0002894 ! olfactory cortex
relationship: overlaps UBERON:0002894 ! olfactory cortex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI
property_value: UBPROP:0000008 "In mammals the fibers of the dorsal lateral olfactory tract either pass under the accessory olfactory formation, or they penetrate through it separating the internal granule cells from the output cells." xsd:string {source="PMID:7437895"}
[Term]
@@ -183061,7 +182965,7 @@ relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: develops_from UBERON:0003080 ! anterior neural tube
relationship: immediate_transformation_of UBERON:0006240 {evidence="definitional"} ! future forebrain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: UBPROP:0000001 "Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010147", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000002 "relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO"}
@@ -183117,7 +183021,7 @@ relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: has_developmental_contribution_from UBERON:0003849 {evidence="definitional"} ! mesencephalic neural crest
relationship: immediate_transformation_of UBERON:0009616 {source="Bgee:AN"} ! presumptive midbrain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI
property_value: editor_note "developmental relationships need revised" xsd:string
property_value: RO:0002171 UBERON:0001894 {exceptions="ZFA", exceptions_url="https://github.com/obophenotype/uberon/issues/378", source="ABA", status="pending"}
property_value: RO:0002171 UBERON:0002028 {exceptions="ZFA", source="ABA", status="pending"}
@@ -183289,7 +183193,7 @@ relationship: has_developmental_contribution_from UBERON:0003851 {evidence="defi
relationship: immediate_transformation_of UBERON:0006222 {evidence="definitional"} ! future diencephalon
relationship: part_of UBERON:0001890 ! forebrain
relationship: present_in_taxon NCBITaxon:7762 {notes="not well differentiated from the cerebrum. (Ariens, p. 868)", source="PMID:8932866"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0002028 {source="ABA"}
property_value: UBPROP:0000001 "The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000101", ontology="TAO", source="ZFIN:curator"}
@@ -183331,7 +183235,7 @@ is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004733 ! segmental subdivision of hindbrain
relationship: contributes_to_morphology_of UBERON:0002028 ! hindbrain
relationship: immediate_transformation_of UBERON:0010092 {evidence="definitional"} ! future metencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:7955
property_value: UBPROP:0000001 "Anterior part of the hindbrain ventral to the cerebellum[BIRNLEX:965]." xsd:string {source="BIRNLEX:965"}
property_value: UBPROP:0000001 "The anterior of two brain vesicles formed by specialization of the rhombencephalon in the developing embryo. It gives rise to cerebellum and pons. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000741", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/metencephalon"}
@@ -183390,7 +183294,7 @@ relationship: capable_of GO:0044058 ! regulation of digestive system process
relationship: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0005290 ! myelencephalon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010486", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008)", source="http://bgee.unil.ch/"}
@@ -183442,7 +183346,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon
relationship: in_lateral_side_of UBERON:0010225 {source="FMA-abduced-lr"} ! thalamic complex
relationship: part_of UBERON:0010225 ! thalamic complex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Brain_chrischan_thalamus.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Brain_chrischan_thalamus.jpg" xsd:anyURI
property_value: RO:0002171 UBERON:0001898 {source="ABA"}
property_value: UBPROP:0000001 "One of a pair of large oval nervous structures made of gray matter and forming most of the lateral walls of the third ventricle of the brain and part of the diencephalon. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000657", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/thalamus"}
property_value: UBPROP:0000001 "Part of the diencephalon consisting of a mass of connecting fibers which relay sensory information to the cerebral cortex.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010483", ontology="AAO", source="AAO:BJB"}
@@ -183502,7 +183406,7 @@ relationship: part_of UBERON:0010225 {missing_from="FMA", source="EHDAA2", sourc
relationship: present_in_taxon NCBITaxon:117569 {source="Ariens, p. 1192"}
relationship: present_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/LocationOfHypothalamus.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9f/LocationOfHypothalamus.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
property_value: RO:0002171 UBERON:0001897 {source="ABA"}
@@ -183562,7 +183466,7 @@ relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001897 ! dorsal plus ventral thalamus
relationship: present_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Epithalamus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Epithalamus.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001903 {source="ABA"}
property_value: RO:0002171 UBERON:0002733 {source="ABA"}
property_value: RO:0002171 UBERON:0002736 {source="ABA"}
@@ -183701,7 +183605,7 @@ relationship: has_part CL:0002220 ! interstitial cell of pineal gland
relationship: part_of UBERON:0015238 {source="ZFA", source="various"} ! pineal complex
relationship: present_in_taxon NCBITaxon:117569 {source="Hardisty, p. 310"}
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
property_value: RO:0002171 UBERON:0001941 {source="ABA"}
@@ -183758,7 +183662,7 @@ relationship: innervates UBERON:0000966 ! retina
relationship: part_of UBERON:0002104 ! visual system
relationship: part_of UBERON:0003931 ! diencephalic white matter
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI
property_value: editor_note "relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with'" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
@@ -183805,7 +183709,7 @@ relationship: capable_of GO:0007595 ! lactation
relationship: develops_from UBERON:0005333 ! mammary bud
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: produces UBERON:0001913 ! milk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Illu_breast_anatomy.jpg" xsd:anyURI
property_value: editor_note "Originally this was classified as a female reproductive structure, as it was in the MP in 2011" xsd:string
property_value: UBPROP:0000001 "Any of the milk-producing apocrine glands typically occurring in pairs in female mammals and consisting of lobes containing clusters of alveoli with a system of ducts to convey the milk to an external nipple or teat. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000398", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/mammary+gland"}
property_value: UBPROP:0000003 "The detailed similarities of mammary glands in living monotremes, marsupials, and eutherians argue for a monophyletic origin of these glands, perhaps by the combination of parts of preexisting sebaceous and sweat glands.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000398", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.224", source="http://bgee.unil.ch/"}
@@ -184019,7 +183923,7 @@ is_a: UBERON:0015233 ! nucleus of dorsal thalamus
relationship: contributes_to_morphology_of UBERON:0001897 ! dorsal plus ventral thalamus
relationship: part_of UBERON:0002704 {source="FMA"} ! metathalamus
relationship: present_in_taxon NCBITaxon:117569 {source="Ariens, p. 1192"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
property_value: UBPROP:0000012 "BTO has distinct classes for body and nucleus, but other sources treat as identical" xsd:string {external_ontology="BTO"}
[Term]
@@ -184064,7 +183968,7 @@ is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0001898 {gci_relation="part_of", gci_filler="NCBITaxon:32524", source="PMC4038951"} ! hypothalamus
relationship: present_in_taxon NCBITaxon:7742 ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI
property_value: UBPROP:0000001 "Area of the forebrain anterior to the posterior tuberculum and the hypothalamus and ventral to the ventral thalamus. See Figure 7, Atlas of Early Zebrafish Brain Development.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000470", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000008 "Located in the hypothalamus in amniotes[PMC4038951]" xsd:string
@@ -184113,8 +184017,8 @@ xref: Wikipedia:Paraventricular_nucleus_of_hypothalamus
is_a: UBERON:0006568 ! hypothalamic nucleus
relationship: contributes_to_morphology_of UBERON:0001898 ! hypothalamus
relationship: part_of UBERON:0002271 ! periventricular zone of hypothalamus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ef/PVNss.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/e/ef/PVNss.jpg/200px-PVNss.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ef/PVNss.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/e/ef/PVNss.jpg/200px-PVNss.jpg" xsd:anyURI
property_value: RO:0002171 UBERON:0001929 {source="ABA"}
property_value: RO:0002171 UBERON:0001932 {source="ABA"}
@@ -184162,7 +184066,7 @@ xref: Wikipedia:Arcuate_nucleus
is_a: UBERON:0006568 ! hypothalamic nucleus
relationship: part_of UBERON:0002271 ! periventricular zone of hypothalamus
relationship: part_of UBERON:0002555 {source="NIFSTD"} ! intermediate hypothalamic region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8c/HypothalamicNuclei.PNG" xsd:anyURI
property_value: RO:0002171 UBERON:0001929 {source="ABA"}
property_value: RO:0002171 UBERON:0001930 {source="ABA"}
property_value: UBPROP:0000012 "the semantics of the BTO class arcuate nucleus are not clear" xsd:string {external_ontology="BTO"}
@@ -184208,7 +184112,7 @@ relationship: develops_from UBERON:0010285 {source="ZFA"} ! midbrain basal plate
relationship: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0002298 ! brainstem
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI
property_value: UBPROP:0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001367", ontology="VHOG", source="DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)", source="http://bgee.unil.ch/"}
[Term]
@@ -184289,7 +184193,7 @@ is_a: UBERON:0002616 ! regional part of brain
relationship: contributes_to_morphology_of UBERON:0000956 ! cerebral cortex
relationship: only_in_taxon NCBITaxon:40674 {source="Wikipedia"} ! Mammalia
relationship: part_of UBERON:0000956 ! cerebral cortex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Neocortex.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/77/Neocortex.jpg" xsd:anyURI
property_value: RO:0002171 UBERON:0002264 {source="ABA"}
property_value: UBPROP:0000003 "The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils" xsd:string {source="PMID:23027930"}
@@ -184382,7 +184286,7 @@ relationship: only_in_taxon NCBITaxon:40674 {source="Wikipedia:Hippocampus"} ! M
relationship: part_of UBERON:0000349 {source="FMA"} ! limbic system
relationship: part_of UBERON:0002421 {source="ABA"} ! hippocampal formation
relationship: part_of UBERON:0002600 {source="FMA"} ! limbic lobe
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray739-emphasizing-hippocampus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Gray739-emphasizing-hippocampus.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001885 {source="ABA"}
property_value: RO:0002171 UBERON:0002601 {source="ABA"}
property_value: UBPROP:0000007 "hippocampal" xsd:string
@@ -184521,7 +184425,7 @@ is_a: UBERON:1000023 ! spleen pulp
relationship: composed_primarily_of CL:0000542 ! lymphocyte
relationship: contributes_to_morphology_of UBERON:0002106 ! spleen
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1191.png" xsd:anyURI
property_value: UBPROP:0000009 "The white pulp contains T cells, B cells and accessory cells. The function of the white pulp is to mount an immunological response to antigens within the blood. The white pulp is present in the form of a periarteriolar lymphoid sheath. This sheath contains B cell follicles and T cells. At the edge of the T zone is a region known as the marginal zone where larger lymphocytes and antigen presenting dendritic cells are located. [Wikipedia:White_pulp]" xsd:string
[Term]
@@ -184644,7 +184548,7 @@ is_a: UBERON:0000463 ! organism substance
relationship: has_part CL:0000019 ! sperm
relationship: has_part UBERON:0006530 ! seminal fluid
relationship: output_of GO:0042713 ! sperm ejaculation
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/40/Human_semen_in_petri_dish2.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/40/Human_semen_in_petri_dish2.jpg" xsd:anyURI
property_value: UBPROP:0000007 "seminal" xsd:string
property_value: UBPROP:0000008 "Note that in this ontology, semen is defined as the sum of sperm and seminal fluid, where seminal fluid is defined in taxonomically generic way (see comments for UBERON:0006530)." xsd:string
@@ -184920,7 +184824,7 @@ is_a: UBERON:8410081 ! blood microvessel
relationship: connects UBERON:0001638 ! vein
relationship: connects UBERON:0001982 ! capillary
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005315", ontology="TAO", source="ZFIN:curator"}
[Term]
@@ -184953,7 +184857,7 @@ intersection_of: connects UBERON:0001982 ! capillary
relationship: connects UBERON:0001637 ! artery
relationship: connects UBERON:0001982 ! capillary
relationship: contributes_to_morphology_of UBERON:0001637 ! artery
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/da/Illu_capillary.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002138", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Small, terminal branch of an artery which generally connects to capillaries.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010253", ontology="AAO", source="AAO:BJB"}
@@ -185004,7 +184908,7 @@ relationship: has_part CL:0000071 {source="AEO"} ! blood vessel endothelial cell
relationship: has_part UBERON:0007500 {source="EHDAA2"} ! epithelial tube open at both ends
relationship: has_quality PATO:0002045 ! dendritic
relationship: part_of UBERON:0004537 ! blood vasculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011004", ontology="AAO", source="AAO:EJS"}
@@ -185048,7 +184952,7 @@ intersection_of: connects UBERON:0001980 ! arteriole
relationship: connects UBERON:0001979 ! venule
relationship: connects UBERON:0001980 ! arteriole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg" xsd:anyURI
property_value: editor_note "not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element" xsd:string
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2186" xsd:string
property_value: UBPROP:0000001 "Any of the tiny blood vessels connecting the arterioles to the venules.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010252", ontology="AAO", source="AAO:BJB"}
@@ -185087,7 +184991,7 @@ relationship: contributes_to_morphology_of UBERON:0001242 ! intestinal mucosa
relationship: has_quality PATO:0002299 {source="Wikipedia:Tubular_gland"} ! tubular
relationship: only_in_taxon NCBITaxon:32523 {notes="further investigation required", source="ISBN:9780521617147"} ! Tetrapoda
relationship: seeAlso UBERON:2005256
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg" xsd:anyURI
property_value: UBPROP:0000001 "In histology, an intestinal crypt, also crypt of LieberkC
relationship: overlaps UBERON:0002298 {notes="modified-source-relation", source="ABA"} ! brainstem
relationship: present_in_taxon NCBITaxon:7762 {source="PMID:8932866"}
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0001894 {source="ABA"}
property_value: UBPROP:0000001 "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010150", ontology="AAO", source="AAO:BJB"}
@@ -186185,7 +186089,7 @@ relationship: develops_from UBERON:0008425 {source="Stedmans"} ! mammary ridge
relationship: only_in_taxon NCBITaxon:32525 ! Theria
relationship: part_of UBERON:0000310 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! breast
relationship: part_of UBERON:0001911 ! mammary gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/59/Female_nipple_profile.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/59/Female_nipple_profile.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/1873" xsd:string
property_value: UBPROP:0000008 "a male mouse has no nipples - mammary tissue regresses during embryonic development" xsd:string
property_value: UBPROP:0000012 "FMA makes this part of the breast, whereas in MA it is part of the mammary gland -" xsd:string {external_ontology="FMA"}
@@ -186331,7 +186235,7 @@ relationship: only_in_taxon NCBITaxon:7742 {source="ISBN:0471888893"} ! Vertebra
relationship: part_of UBERON:0001895 {source="FMA", source="MA"} ! metencephalon
relationship: present_in_taxon NCBITaxon:117569 {source="ISBN:0471888893"}
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001893 {source="ABA"}
property_value: RO:0002171 UBERON:0002298 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002174 NCBITaxon:117569 {source="http://icb.oxfordjournals.org/content/42/4/743.full"}
@@ -186386,7 +186290,7 @@ relationship: contributes_to_morphology_of UBERON:0010011 ! collection of basal
relationship: in_lateral_side_of UBERON:0001891 {source="FMA-abduced-lr"} ! midbrain
relationship: part_of UBERON:0002420 {source="NIF"} ! basal ganglion
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Midbraincrosssection.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Midbraincrosssection.png" xsd:anyURI
property_value: editor_note "TODO - In BTO and NIF, part of basal ganglion which is part of telencephalon - but this is inconsistent with being part of midbrain, if these are spatially disjoint, as in ABA" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
@@ -186421,7 +186325,7 @@ relationship: has_part UBERON:0004848 ! respiratory system arterial endothelium
relationship: has_part UBERON:0012416 ! respiratory system arterial smooth muscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002048 ! lung
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png" xsd:anyURI
[Term]
id: UBERON:0002042
@@ -186496,8 +186400,8 @@ relationship: capable_of_part_of GO:0055074 {source="Wikipedia"} ! calcium ion h
relationship: contains_process GO:0006590 ! thyroid hormone generation
relationship: only_in_taxon NCBITaxon:7711 {source="Wikipedia:Endostyle"} ! Chordata
relationship: transformation_of UBERON:0007689 ! thyroid diverticulum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a3/Illu_thyroid_parathyroid.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010544", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000418", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes" xsd:string {scope="NCBITaxon:32443", source="Romer", source="Wikipedia:Thyroid_gland#Other_animals"}
@@ -186616,7 +186520,7 @@ relationship: composed_primarily_of UBERON:0000055 ! vessel
relationship: has_part UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0007798 ! vascular system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "see also: vascular system. Consider merging?" xsd:string
property_value: UBPROP:0000007 "vascular" xsd:string
@@ -186734,7 +186638,7 @@ is_a: UBERON:0009753 {source="MA"} ! adrenal gland cortex zone
relationship: capable_of GO:0032342 ! aldosterone biosynthetic process
relationship: contributes_to_morphology_of UBERON:0001235 ! adrenal cortex
relationship: has_part CL:1000427 {source="FMA"} ! adrenal cortex chromaffin cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray1185.png" xsd:anyURI
[Term]
id: UBERON:0002056
@@ -186757,7 +186661,7 @@ intersection_of: UBERON:0005624 ! suprarenal artery
intersection_of: branching_part_of UBERON:0001184 ! renal artery
relationship: branching_part_of UBERON:0001184 ! renal artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/61/Gray1121.png" xsd:anyURI
[Term]
id: UBERON:0002057
@@ -186798,7 +186702,7 @@ xref: UMLS:C0015801 {source="ncithesaurus:Femoral_Artery"}
xref: Wikipedia:Femoral_artery
is_a: UBERON:0004573 ! systemic artery
relationship: branching_part_of UBERON:0001308 {source="FMA", source="WP"} ! external iliac artery
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray546.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray546.png" xsd:anyURI
property_value: UBPROP:0000001 "Artery which supplies blood via branches to the hindlimbs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010222", ontology="AAO", source="AAO:BJB"}
[Term]
@@ -186857,7 +186761,7 @@ is_a: UBERON:0005256 ! trunk mesenchyme
is_a: UBERON:0009751 ! cardiac mesenchyme
is_a: UBERON:0014387 ! mesenchyme derived from neural crest
relationship: part_of UBERON:0002165 {source="ZFA"} ! endocardium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png" xsd:anyURI
property_value: UBPROP:0000001 "Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001317", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000002 "relationship loss: develops_from endocardial ring (TAO:0005072)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001317", ontology="TAO"}
property_value: UBPROP:0000003 "(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000932", ontology="VHOG", source="DOI:10.1038/35047564 Stainier DYR, Zebrafish genetics and vertebrate heart formation. Nature Reviews Genetics (2001) Figure 3", source="http://bgee.unil.ch/"}
@@ -186894,7 +186798,7 @@ is_a: UBERON:0004151 ! cardiac chamber
disjoint_from: UBERON:0006615 ! venous sinus
relationship: immediate_transformation_of UBERON:0007278 {source="Bgee:AN"} ! presumptive sinus venosus
relationship: part_of UBERON:0002350 {source="VHOG"} ! conducting system of heart
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png" xsd:anyURI
property_value: UBPROP:0000001 "Heart region collecting blood from the paired common cardinal veins and delivering to the atrium. One of four components of the heart. The sinus venosus also acts as a pacemaker and is the first to contract. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000154", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Part of the circulatory system which receives blood from the systemic veins and contracts to pump the blood into the atrium of the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010505", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000177", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428", source="http://bgee.unil.ch/"}
@@ -186932,7 +186836,7 @@ xref: Wikipedia:Umbilical_vein
is_a: UBERON:0001638 ! vein
is_a: UBERON:0010260 ! umbilical blood vessel
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray502.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb" xsd:string
[Term]
@@ -186979,7 +186883,7 @@ relationship: immediate_transformation_of UBERON:0010083 {evidence="definitional
relationship: part_of UBERON:0002097 {source="FMA"} ! skin of body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: superficial_to UBERON:0002072 ! hypodermis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg" xsd:anyURI
property_value: editor_note "Consider adding a layer-of-skin grouping class for all skin layers" xsd:string
property_value: UBPROP:0000001 "A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001119", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000108", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1", source="http://bgee.unil.ch/"}
@@ -187047,7 +186951,7 @@ relationship: deep_to UBERON:0002067 ! dermis
relationship: part_of UBERON:0002199 {source="ZFA"} ! integument
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: superficial_to UBERON:0001015 ! musculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
property_value: UBPROP:0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001136", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]." xsd:string {source="FMA:70544"}
property_value: UBPROP:0000007 "hypodermal" xsd:string
@@ -187088,7 +186992,7 @@ relationship: overlaps UBERON:0001037 ! strand of hair
relationship: part_of UBERON:0001003 {source="FMA"} ! skin epidermis
relationship: part_of UBERON:0011932 {source="DOI:10.1016/j.cub.2008.12.005"} ! pilosebaceous unit
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4d/Hair_follicle-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4d/Hair_follicle-en.svg" xsd:anyURI
property_value: UBPROP:0000003 "The earliest reliable record of hair is found in a fossil of the Paleocene period, in which the structure of hair cuticles is preserved. Its appearance suggests that the complicated structure of the hair follicle, closely similar to that of present-day mammals, had already appeared at this time.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001268", ontology="VHOG", source="ISBN:978-4431998051 Morioka K, Hair follicle: differentiation under the electron microscope, An atlas (2005) p.3", source="http://bgee.unil.ch/"}
[Term]
@@ -187214,7 +187118,7 @@ intersection_of: UBERON:0002081 ! cardiac atrium
intersection_of: in_right_side_of UBERON:0000948 ! heart
relationship: connected_to UBERON:0004537 ! blood vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb" xsd:string
property_value: UBPROP:0000001 "Right cardiac chamber which is continuous with the superior vena cava and inferior vena cava.[FMA]" xsd:string {source="FMA:7096"}
@@ -187254,7 +187158,7 @@ intersection_of: UBERON:0002081 ! cardiac atrium
intersection_of: in_left_side_of UBERON:0000948 ! heart
relationship: connected_to UBERON:0004537 ! blood vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb" xsd:string
property_value: UBPROP:0000001 "Left cardiac chamber which is continuous with the pulmonary venous trunk.[FMA]" xsd:string {source="FMA:7097"}
@@ -187295,7 +187199,7 @@ relationship: connected_to UBERON:0004537 ! blood vasculature
relationship: develops_from UBERON:0009889 {source="PMID:17276708"} ! secondary heart field
relationship: has_developmental_contribution_from UBERON:0004706 {source="cjm"} ! bulbus cordis
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb" xsd:string
property_value: UBPROP:0000001 "The muscular chamber on the right and in front of the left ventricle. It generally receives venous blood from the right atrium and conveys it into the pulmonary artery. [(1988)_Dorian_AF, Amsterdam, Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B._Anatomy, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier's_Encyclopaedic_Dictionary_of_Medicine][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000717", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -187422,7 +187326,7 @@ relationship: connected_to UBERON:0004537 ! blood vasculature
relationship: continuous_with UBERON:0000947 ! aorta
relationship: develops_from UBERON:0004140 {source="GO"} ! primary heart field
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/20/Diagram_of_the_human_heart_%28cropped%29.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb" xsd:string
property_value: UBPROP:0000001 "Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000718", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -187457,7 +187361,7 @@ intersection_of: adjacent_to UBERON:0002078 ! right cardiac atrium
intersection_of: adjacent_to UBERON:0002079 ! left cardiac atrium
relationship: adjacent_to UBERON:0002078 ! right cardiac atrium
relationship: adjacent_to UBERON:0002079 ! left cardiac atrium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png" xsd:anyURI
property_value: UBPROP:0000001 "The partition separating the right and left atria of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000385", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/interatrial+septum"}
property_value: UBPROP:0000003 "The tetrapod clade develops a complete atrial septum and loses the fifth aortic arch altogether.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000385", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"}
@@ -187548,7 +187452,7 @@ relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata
relationship: overlaps UBERON:0000026 ! appendage
relationship: part_of UBERON:0011249 ! appendicular skeletal system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Appendicular_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision consisting of all the skeletal elements in the pectoral and pelvic appendage complexes.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000076", ontology="VSAO", source="PSPUB:0000170", source="https://orcid.org/0000-0002-6601-2165"}
property_value: UBPROP:0000001 "Skeletal system that consists of the paired fins (pectoral or pelvic fins).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000027", ontology="TAO", source="TAO:wd"}
@@ -187643,7 +187547,7 @@ intersection_of: adjacent_to UBERON:0002084 ! heart left ventricle
relationship: adjacent_to UBERON:0002080 ! heart right ventricle
relationship: adjacent_to UBERON:0002084 ! heart left ventricle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb" xsd:string
property_value: UBPROP:0000001 "The partition separating the right and left ventricles of the heart. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000386", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/interventricular+septum"}
@@ -187673,7 +187577,7 @@ xref: UMLS:C0025474 {source="ncithesaurus:Mesentery"}
xref: Wikipedia:Mesentery#Mesentery_.28general.29
is_a: UBERON:0000042 ! serous membrane
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray1038.png" xsd:anyURI
property_value: UBPROP:0000007 "mesenteric" xsd:string
property_value: UBPROP:0000012 "in Uberon, this term is used in the generic sense, not necessarily restricted to the peritoneum, consistent with FMA. WP: 'In anatomy, the mesentery is the double layer of peritoneum that suspends the jejunum and ileum from the posterior wall of the abdomen. Its meaning, however, is frequently extended to include double layers of peritoneum connecting various components of the abdominal cavity.'. TODO - check. Consider FMA:259286 - Region of mesentery." xsd:string {external_ontology="FMA"}
@@ -187714,7 +187618,7 @@ relationship: composed_primarily_of UBERON:0000014 ! zone of skin
relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer
relationship: part_of UBERON:0002199 ! integument
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Skin.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_M_Skin.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Skin.glb" xsd:string
@@ -187947,7 +187851,7 @@ intersection_of: part_of UBERON:0010709 ! pelvic complex
relationship: develops_from UBERON:0005418 ! hindlimb bud
relationship: has_skeleton UBERON:0001441 ! hindlimb skeleton
relationship: part_of UBERON:0000154 ! posterior region of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray1239.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray1239.png" xsd:anyURI
property_value: UBPROP:0000001 "Lower limb, which connects the pes with the pelvic girdle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000219", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000337", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "crural" xsd:string
@@ -188004,7 +187908,7 @@ xref: XAO:0003195
xref: ZFA:0001138
is_a: UBERON:0001032 ! sensory system
relationship: capable_of_part_of GO:0007605 ! sensory perception of sound
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Anatomy_of_the_Human_Ear.svg" xsd:anyURI
property_value: UBPROP:0000001 "The sensory system used for balance and hearing.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000631", ontology="AAO", source="AAO:EJS"}
[Term]
@@ -188047,7 +187951,7 @@ is_a: UBERON:0017672 ! abdominal viscera
relationship: develops_from UBERON:0006293 ! spleen primordium
relationship: only_in_taxon NCBITaxon:7776 {source="multiple sources - true spleen appear in jawed vertebrates"} ! Gnathostomata
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d6/Illu_spleen.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Spleen.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spleen.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spleen.glb" xsd:string
@@ -188112,7 +188016,7 @@ relationship: produces UBERON:0001970 ! bile
relationship: site_of GO:0002384 ! hepatic immune response
relationship: site_of GO:0005978 ! glycogen biosynthetic process
relationship: site_of GO:0005980 ! glycogen catabolic process
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb" xsd:string
property_value: UBPROP:0000001 "Organ which secretes bile and participates in formation of certain blood proteins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010111", ontology="AAO", source="AAO:BJB"}
@@ -188168,7 +188072,7 @@ relationship: contributes_to_morphology_of UBERON:0000160 ! intestine
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0000160 ! intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/82/Stomach_colon_rectum_diagram.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb" xsd:string
property_value: UBPROP:0000001 "The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001323", ontology="TAO", source="ZFIN:curator"}
@@ -188244,8 +188148,8 @@ relationship: never_in_taxon NCBITaxon:10114 {source="ISBN:9780120749034"}
relationship: never_in_taxon NCBITaxon:8801 {source="GOC:mr", source="ISBN:9781840761122"}
relationship: never_in_taxon NCBITaxon:8930 {source="GOC:mr", source="ISBN:9781840761122"}
relationship: part_of UBERON:0002294 ! biliary system
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/b1/GallbladderAnatomy-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/f/f4/Abdomal_organs.svg" xsd:anyURI
property_value: UBPROP:0000001 "Membranous muscular sac in which the bile from the liver remains stored until it is required. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000221", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Organ attached to the liver which stores bile and empties into the duodenum via the bile duct as needed for digestion.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010114", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000002 "relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010114", ontology="AAO"}
@@ -188397,7 +188301,7 @@ relationship: never_in_taxon NCBITaxon:7955 {source="ZFA:0000348"}
relationship: part_of UBERON:0002108 ! small intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: proximalmost_part_of UBERON:0002108 ! small intestine
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Tractus_intestinalis_duodenum.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb" xsd:string
property_value: UBPROP:0000001 "The fixed portion of the small intestine deeply lodged in the posterior wall of the abdomen and extending from the pylorus to the beginning of the jejunum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000052", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -188439,7 +188343,7 @@ relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine
relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
relationship: part_of UBERON:0002108 ! small intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
property_value: editor_note "TODO consider ZFA:0001323 mid intestine, see also small intestine" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb" xsd:string
@@ -188483,7 +188387,7 @@ is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract
relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
property_value: editor_note "TODO consider ZFA:0000706 posterior intestine, see also colon" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb" xsd:string
@@ -188705,7 +188609,7 @@ is_a: UBERON:0007245 ! nuclear complex of neuraxis
is_a: UBERON:0019263 ! gray matter of hindbrain
relationship: part_of UBERON:0003023 {source="NIFSTD"} ! pontine tegmentum
relationship: part_of UBERON:0016490 ! auditory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray713.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002597 {source="ABA"}
property_value: RO:0002171 UBERON:0006840 {source="ABA"}
property_value: RO:0002171 UBERON:0007634 {source="ABA"}
@@ -188753,7 +188657,7 @@ relationship: capable_of_part_of GO:0007613 {source="Wikipedia"} ! memory
relationship: contributes_to_morphology_of UBERON:0002037 ! cerebellum
relationship: part_of UBERON:0002037 ! cerebellum
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002130 {source="ABA"}
property_value: UBPROP:0000001 "The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function[GO][GO:0021695]." xsd:string {source="GO:0021695"}
@@ -188796,7 +188700,7 @@ relationship: part_of UBERON:0002314 {source="MA"} ! midbrain tectum
relationship: part_of UBERON:0011357 ! Reissner's fiber
relationship: present_in_taxon NCBITaxon:7742 {source="multiple"} ! Vertebrata
relationship: produces PR:000015658 ! SCO-spondin
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray715.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Gray715.png" xsd:anyURI
property_value: IAO:0000232 "Hypendymal cells being part of the subcommissural organ is not axiomatized as it is rare in non-mammals. Consider using GCIs if this axiom needs to be added." xsd:string
[Term]
@@ -188849,7 +188753,7 @@ is_a: UBERON:0009662 ! hindbrain nucleus
is_a: UBERON:8440015 ! noradrenergic cell groups
relationship: capable_of GO:0048243 ! norepinephrine secretion
relationship: part_of UBERON:0003023 {notes="check ZFA", source="NIFSTD"} ! pontine tegmentum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray709.png" xsd:anyURI
property_value: editor_note "TODO - check ZFA/pons. also GO says part of dorsorostral pons" xsd:string
property_value: RO:0002171 UBERON:0002047 {source="ABA"}
property_value: RO:0002171 UBERON:0002267 {source="ABA"}
@@ -188887,7 +188791,7 @@ is_a: UBERON:0004133 ! salivatory nucleus
is_a: UBERON:0007635 ! nucleus of medulla oblongata
relationship: immediate_transformation_of UBERON:0010125 {evidence="definitional"} ! future superior salivatory nucleus
relationship: part_of UBERON:0003023 ! pontine tegmentum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray788.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002143 {source="ABA"}
property_value: RO:0002171 UBERON:0002147 {source="ABA"}
property_value: RO:0002171 UBERON:0002151 {source="ABA"}
@@ -188940,7 +188844,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005983 ! heart layer
relationship: has_part UBERON:0005316 ! endocardial endothelium
relationship: immediate_transformation_of UBERON:0007280 {source="Bgee:AN"} ! presumptive endocardium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png" xsd:anyURI
property_value: UBPROP:0000001 "Layer that lines the lumen of the heart.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001320", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010408", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber." xsd:string {source="FMA:7280"}
@@ -188997,7 +188901,7 @@ is_a: UBERON:0002048 ! lung
intersection_of: UBERON:0002048 ! lung
intersection_of: in_right_side_of UBERON:0000170 ! pair of lungs
relationship: in_right_side_of UBERON:0000170 ! pair of lungs
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/32/Gray972.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb" xsd:string
@@ -189026,7 +188930,7 @@ is_a: UBERON:0002048 ! lung
intersection_of: UBERON:0002048 ! lung
intersection_of: in_left_side_of UBERON:0000170 ! pair of lungs
relationship: in_left_side_of UBERON:0000170 ! pair of lungs
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dd/Gray973.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb" xsd:string
@@ -189083,7 +188987,7 @@ xref: Wikipedia:Alveolar_duct
is_a: UBERON:0000117 ! respiratory tube
relationship: part_of UBERON:0006524 ! alveolar system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8f/Gray975.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8f/Gray975.png" xsd:anyURI
property_value: UBPROP:0000008 "In human anatomy, respiratory bronchioles exists proximal to the alveolar ducts. The epithelial lining consists of smooth muscle knobs covered by nonciliated, simple cuboidal cells. The smooth muscle constricts under parasympathetic innervation and relax under sympathetic innervation" xsd:string
[Term]
@@ -189111,7 +189015,7 @@ xref: ZFA:0000605
is_a: UBERON:0006127 ! funiculus of spinal cord
is_a: UBERON:0015212 ! lateral structure
relationship: in_lateral_side_of UBERON:0002318 {source="FMA-abduced-lr"} ! white matter of spinal cord
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI
[Term]
id: UBERON:0002183
@@ -189149,7 +189053,7 @@ relationship: has_part UBERON:0004242 ! bronchus smooth muscle
relationship: has_part UBERON:8410043 ! bronchus submucosal gland
relationship: part_of UBERON:0000101 {source="FMA"} ! lobe of lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI
property_value: UBPROP:0000010 "They have relatively large lumens that are lined by respiratory epithelium. There is a smooth muscle layer below the epithelium arranged as two ribbons of muscle that spiral in opposite directions. This smooth muscle layer contains seromucous glands. Irregularly arranged plates of hyaline cartilage surround the smooth muscle. These plates give structural support to the bronchus and maintain the patency of the lumen." xsd:string
[Term]
@@ -189183,7 +189087,7 @@ relationship: overlaps UBERON:8600017 ! bronchopulmonary segment
relationship: part_of UBERON:0000101 {source="FMA"} ! lobe of lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: proximally_connected_to UBERON:0002183 ! lobar bronchus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb" xsd:string
@@ -189222,7 +189126,7 @@ is_a: UBERON:0000117 ! respiratory tube
relationship: located_in UBERON:0002224 ! thoracic cavity
relationship: never_in_taxon NCBITaxon:8507 {source="Wikipedia"}
relationship: part_of UBERON:0007196 ! tracheobronchial tree
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/18/Respiratory_system_complete_numbered.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb" xsd:string
@@ -189259,7 +189163,7 @@ xref: Wikipedia:Bronchiole
is_a: UBERON:0000117 ! respiratory tube
relationship: branching_part_of UBERON:0007196 {source="FMA"} ! tracheobronchial tree
relationship: part_of UBERON:0002048 {source="MA"} ! lung
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
property_value: UBPROP:0000007 "bronchiolar" xsd:string
property_value: UBPROP:0000010 "lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer" xsd:string {source="ISBN:0123813611"}
property_value: UBPROP:0000012 "In FMA2 and FMA3, lobular bronchiole is an exact synonym of bronchiole; however, there are two distinct terms for the corresponding epithelium." xsd:string {external_ontology="FMA"}
@@ -189288,7 +189192,7 @@ relationship: distally_connected_to UBERON:0002188 ! respiratory bronchiole
relationship: distally_connected_to UBERON:0008874 ! pulmonary acinus
relationship: part_of UBERON:0010369 ! secondary pulmonary lobule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
[Term]
id: UBERON:0002188
@@ -189314,7 +189218,7 @@ relationship: distally_connected_to UBERON:0002173 ! pulmonary alveolar duct
relationship: part_of UBERON:0008874 {source="ISBN:0123813611"} ! pulmonary acinus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: proximally_connected_to UBERON:0002187 ! terminal bronchiole
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
property_value: UBPROP:0000008 "mice have few or none of these structures, with the terminal bronchioles transitioning directly to the alveolary ducts" xsd:string {source="ISBN:0123813611"}
[Term]
@@ -189383,7 +189287,7 @@ intersection_of: bounding_layer_of UBERON:0000029 ! lymph node
relationship: bounding_layer_of UBERON:0000029 ! lymph node
relationship: composed_primarily_of UBERON:0002384 ! connective tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/92/Lymphknoten_(Schwein).jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/92/Lymphknoten_(Schwein).jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb" xsd:string
property_value: UBPROP:0000008 "from its internal surface are given off a number of membranous processes or trabeculae, consisting, in man, of connective tissue, with a small admixture of plain muscle fibers; but in many of the lower animals composed almost entirely of involuntary muscle[WP]" xsd:string
@@ -189409,7 +189313,7 @@ intersection_of: UBERON:0000440 ! trabecula
intersection_of: part_of UBERON:0000029 ! lymph node
relationship: part_of UBERON:0000029 ! lymph node
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Gray598.png" xsd:anyURI
[Term]
id: UBERON:0002196
@@ -189472,7 +189376,7 @@ relationship: has_part CL:0000467 {source="ZFA"} ! adrenocorticotropic hormone s
relationship: has_part CL:0002312 ! somatotroph
relationship: only_in_taxon NCBITaxon:7742 {source="PMID:19084529"} ! Vertebrata
relationship: part_of UBERON:0000007 ! pituitary gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray1181.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray1181.png" xsd:anyURI
property_value: UBPROP:0000001 "Region of the pituitary gland derived from the buccal protrusion consisting of three regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010540", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin. In contrast to mamalian vertebrates, the adenohypophysis remains in a subepithelial position and there exists no equivalent of Rathke's pouch in zebrafish. Herzog et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001282", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000141", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5", source="http://bgee.unil.ch/"}
@@ -189541,7 +189445,7 @@ relationship: develops_from UBERON:0002346 ! neurectoderm
relationship: only_in_taxon NCBITaxon:7742 {source="PMID:19084529"} ! Vertebrata
relationship: part_of UBERON:0000007 {source="ZFA"} ! pituitary gland
relationship: present_in_taxon NCBITaxon:117569 {source="Ariens, p. 1192"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Pituitary_gland_representation.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Pituitary_gland_representation.PNG" xsd:anyURI
property_value: editor_note "request magnocellular cell from CL. Request oxytocin secretion from GO. Notes: 'The hypophysis or pituitary gland is derived, in part from an ectodermal outpocketing of the stomodeum (Rathke's Pouch) and in part from the floor of the diencephalon'" xsd:string {source="http://syllabus.med.unc.edu/courseware/embryo_images/"}
property_value: UBPROP:0000001 "The infundibular part of the pituitary gland consisting of two regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010537", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "It (the hypophysis) develops embryonically in all vertebrates from two ectodermal evaginations that meet and unite. An infundibulum grows ventrally from the diencephalon of the brain, and Rathke's pouch extends dorsally from the roof of the developing mouth, or stomodaeum. The infundibulum remains connected to the floor of the diencephalon, which becomes the hypothalamus, and gives rise to the part of the gland known as the neurohypophysis. (...) Rathke's pouch loses its connection with the stomodaeum in most adult vertebrates and gives rise to the rest of the gland, the adenohypophysis. (...) A well-developed hypophyseal system with functional connections to the hypothalamus is unique to craniates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000142", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5", source="http://bgee.unil.ch/"}
@@ -189770,7 +189674,7 @@ relationship: contributes_to_morphology_of UBERON:0001894 ! diencephalon
relationship: part_of UBERON:0002272 {source="ABA"} ! medial zone of hypothalamus
relationship: part_of UBERON:0002770 {source="GO definition"} ! posterior hypothalamic region
relationship: present_in_taxon NCBITaxon:117569 {source="Hardisty, p. 320-1"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1180.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001935 {source="ABA"}
property_value: RO:0002171 UBERON:0002035 {source="ABA"}
property_value: RO:0002171 UBERON:0002634 {source="ABA"}
@@ -189928,7 +189832,7 @@ intersection_of: UBERON:0000054 ! macula
intersection_of: part_of UBERON:0001853 ! utricle of membranous labyrinth
relationship: contributes_to_morphology_of UBERON:0001853 ! utricle of membranous labyrinth
relationship: part_of UBERON:0001853 ! utricle of membranous labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI
[Term]
id: UBERON:0002215
@@ -189951,7 +189855,7 @@ is_a: UBERON:0002213 ! cartilaginous joint
intersection_of: UBERON:0002209 ! fibrous joint
intersection_of: composed_primarily_of UBERON:0001994 ! hyaline cartilage tissue
relationship: composed_primarily_of UBERON:0001994 ! hyaline cartilage tissue
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray297.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/76/Gray297.png" xsd:anyURI
property_value: editor_note "consider adding link to hyaline cartilage" xsd:string
property_value: editor_note "WP considers epiphyseal plates as subtypes of this" xsd:string
@@ -189969,7 +189873,7 @@ xref: SCTID:1584001
xref: Wikipedia:Symphysis
is_a: UBERON:0002209 {source="MA"} ! fibrous joint
is_a: UBERON:0002213 {source="FMA"} ! cartilaginous joint
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray298.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray298.png" xsd:anyURI
property_value: editor_note "consider adding fibrocartilage class" xsd:string
[Term]
@@ -190059,8 +189963,8 @@ intersection_of: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0002323 ! coelemic cavity lumen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" xsd:string
[Term]
@@ -190103,8 +190007,8 @@ relationship: located_in UBERON:0002295 {source="Wikipedia:Scala_media"} ! scala
relationship: only_in_taxon NCBITaxon:32523 {notes="https://github.com/obophenotype/uberon/issues/387"} ! Tetrapoda
relationship: part_of UBERON:0001855 {source="MA"} ! cochlear duct of membranous labyrinth
relationship: present_in_taxon NCBITaxon:40674 ! Mammalia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Cochlea-crosssection.svg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:8292
property_value: RO:0002174 NCBITaxon:8457
property_value: UBPROP:0000003 "The auditory hair cells in tetrapods are located in the inner ear in a structure known as the basilar papilla. In mammals this structure (along with some related structure) is called the organ of Corti.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001567", ontology="VHOG", source="ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.33", source="http://bgee.unil.ch/"}
@@ -190192,7 +190096,7 @@ is_a: UBERON:0002228 ! rib
intersection_of: UBERON:0002228 ! rib
intersection_of: connected_to UBERON:0000975 ! sternum
relationship: connected_to UBERON:0000975 ! sternum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray115.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Gray115.png" xsd:anyURI
[Term]
id: UBERON:0002240
@@ -190254,7 +190158,7 @@ relationship: has_part CL:0005000 {source="ZFA"} ! spinal cord interneuron
relationship: immediate_transformation_of UBERON:0006241 {evidence="definitional"} ! future spinal cord
relationship: part_of UBERON:0001017 ! central nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI
property_value: editor_note "TODO - add superclass to unify with VNC?" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb" xsd:string
@@ -190317,7 +190221,7 @@ relationship: has_part CHEBI:60924
relationship: has_part CL:0000138 ! chondrocyte
relationship: has_part UBERON:0011860 ! collection of collagen fibrils
relationship: part_of UBERON:0001066 ! intervertebral disk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png" xsd:anyURI
property_value: UBPROP:0000010 "The nucleus pulposus consists of chondrocytes, collagen fibrils, and proteoglycan aggrecans that have hyaluronic long chains which attract water. Attached to each hyaluronic chain are side chains of chondroitin sulfate and keratan sulfate[Wikipedia:Nucleus_pulposus]" xsd:string
property_value: UBPROP:0000012 "we group two FMA classes together" xsd:string {external_ontology="FMA"}
@@ -190359,7 +190263,7 @@ relationship: has_quality PATO:0000588 {gci_relation="part_of", gci_filler="NCBI
relationship: only_in_taxon NCBITaxon:8287 ! Sarcopterygii
relationship: part_of UBERON:0000004 ! nose
relationship: part_of UBERON:0009954 ! vomeronasal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray51.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray51.png" xsd:anyURI
property_value: UBPROP:0000001 "An organ thought to supplement the olfactory system in receiving pheromonic communication. The sensory part of the organ is in two long, thin sacs, situated on either side of the nasal septum at its base. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000665", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vomeronasal+organ"}
property_value: UBPROP:0000003 "(...) the vomeronasal organ is known only in some tetrapods. It is absent in most turtles, crocodiles, birds, some bats, and aquatic mammals. In amphibians, it is in a recessed area off the main nasal cavity. (...) In mammals possesing this organ, it is an isolated area of olfactory membrane within the nasal cavity that is usually connected to the mouth via the nasopalatine duct (reference 1); The opinions concerning the presence and functioning of the vomeronasal organ in humans are controversial. The vomeronasal cavities appear early in human foetuses. (...) Historical examination of the nasal septum revealed the presence of vomeronasal cavities in approximately 70% of adults. In contrast to the situation in other mammals, the organ is not supported by a rigid tube of bone or cartilage (reference 2); (...) the best evidence for the homology of the human VNO to that of other primates (and of mammals in general) is ontogenetic in nature, based on a common embryonic origin from a thickening (vomeronasal primordium) on the medial aspect of each olfactory pit (reference 3); (...) suggesting that lungfish possess a region homologous to the accessory olfactory bulb of tetrapods. Based on these results, it seems appropriate to refer to the recess epithelium as a primordium of the vomeronasal organ (reference 4). [debated][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000665", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.669 (ref.1), http://www.ncbi.nlm.nih.gov/pubmed/9866877 Doving KB, Trotier D, Review: Structure and function of the vomeronasal organ. The Journal of Experimental Biology (1998) (ref.2), DOI:10.1046/j.1469-7580.2001.19810077.x Smith TD, Siegel MI, Bonar CJ, Bhatnagar KP, Mooney MP, Burrows AM, Smith MA, Maico LM, The existence of the vomeronasal organ in postnatal chimpanzees and evidence for its homology with that of humans. J Anat (2001) (ref.3) , DOI:10.1002/ar.22415 Nakamuta S, Nakamuta N, Taniguchi K, Taniguchi K, Histological and ultrastructural characteristics of the primordial vomeronasal organ in lungfish. Anat Rec (Hoboken) (2012) (ref.4)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "Generally formed only in tetrapods; lungfish have rudimentary VN organs; true VN organs are not normally found in recent fishes, birds, aquatic reptiles, aquatic mammals (Bertmar 1980). Humans: Its presence in many animals has been widely studied and the importance of the vomeronasal system to the role of reproduction and social behavior (through influence on anterior hypothalamus) has been shown in many studies. Its presence and functionality in humans was controversial, though most studies agree the organ regresses during fetal development. Many genes essential for VNO function in animals (such as TRPC2) are non-functional in humans (Liman ER. Use it or lose it: molecular evolution of sensory signaling in primates. Pflugers Arch. 2006;453(2):125-31.)" xsd:string
@@ -190416,7 +190320,7 @@ relationship: contributes_to_morphology_of UBERON:0002315 ! gray matter of spina
relationship: has_part CL:0000101 ! sensory neuron
relationship: in_lateral_side_of UBERON:0002315 {source="FMA-abduced-lr"} ! gray matter of spinal cord
relationship: part_of UBERON:0002315 ! gray matter of spinal cord
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI
[Term]
id: UBERON:0002257
@@ -190506,7 +190410,7 @@ xref: ZFA:0000652
is_a: UBERON:0009623 {source="FMA"} ! spinal nerve root
relationship: capable_of_part_of GO:0019230 {source="Wikipedia"} ! proprioception
relationship: extends_fibers_into UBERON:0000044 ! dorsal root ganglion
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "In anatomy and neurology, the dorsal root (or posterior root) is the afferent sensory root of a spinal nerve. At the distal end of the dorsal root is the dorsal root ganglion, which contains the neuron cell bodies of the nerve fibres conveyed by the root. If the dorsal root of a spinal nerve were severed it would lead to numbness in certain areas of the body. The lateral division of the dorsal root contains lightly myelinated and unmyelinated axons of small diameter. These transmit pain and temperature sensation from the body. These fibers cross through the anterior white commissure to form the Anterior lateral system in the lateral funiculus. The medial division of the dorsal root contains myelinated axons of larger diameter. These transmit information of discriminative touch, pressure, vibration, and conscious proprioception originating from spinal levels C2 through S5. These fibers are pushed in towards the posterior medial sulcus to form the fasciculus gracilis and the fasciculus cuneatus. [WP,unvetted][Wikipedia:Posterior_root_of_spinal_nerve]." xsd:string {source="Wikipedia:Posterior_root_of_spinal_nerve"}
[Term]
@@ -190557,8 +190461,8 @@ relationship: has_part CL:0000626 {source="ZFA"} ! olfactory granule cell
relationship: in_lateral_side_of UBERON:0001893 {source="ISBN:0471888893"} ! telencephalon
relationship: part_of UBERON:0005366 ! olfactory lobe
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/1543%2CVesalius%27OlfactoryBulbs.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f9/1543,Vesalius%27OlfactoryBulbs.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d2/1543%2CVesalius%27OlfactoryBulbs.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f9/1543,Vesalius%27OlfactoryBulbs.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
property_value: RO:0002171 UBERON:0001950 {source="ABA"}
@@ -190605,7 +190509,7 @@ intersection_of: overlaps UBERON:0002264 ! olfactory bulb
relationship: overlaps UBERON:0002264 ! olfactory bulb
relationship: part_of UBERON:0011299 ! white matter of telencephalon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png" xsd:anyURI
property_value: UBPROP:0000001 "A nervelike, white band composed primarily of nerve fibres originating from the mitral cells and tufted cells of the olfactory bulb but also containing the scattered cells of the anterior olfactory nucleus[BTO:0003647]." xsd:string {source="BTO:0003647"}
property_value: UBPROP:0000001 "The olfactory tract is a bundle of axons connecting the mitral and tufted cells of the olfactory bulb to several target regions in the brain, including piriform cortex, amygdala, and entorhinal cortex. It is a narrow white band, triangular on coronal section, the apex being directed upward. It lies in the olfactory sulcus on the inferior surface of the frontal lobe, and divides posteriorly into two striæ, a medial olfactory stria and a lateral olfactory stria.[Wikipedia]." xsd:string {source="Wikipedia:Olfactory_tract"}
property_value: UBPROP:0000001 "Tract of brain which is continuous with olfactory bulb and the cerebral cortex.[FMA]" xsd:string {source="FMA"}
@@ -190698,7 +190602,7 @@ xref: SCTID:361552007
xref: Wikipedia:Reticular_formation
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0002298 ! brainstem
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9b/Gray701.png" xsd:anyURI
property_value: IAO:0000232 "this class denotes the generic structure, and not a specific one such as medullary or pontine reticular formation." xsd:string
property_value: UBPROP:0000008 "It is essential for governing some of the basic functions of higher organisms, and is one of the phylogenetically oldest portions of the brain." xsd:string
property_value: UBPROP:0000012 "FMA has a spinal cord reticular formation but we follow NNs (classical) to restrict this to brainstem structures. This means we also include the MA class for brainstem reticular formation here. FMA has subtypes of reticular formation but we treat this as a composite structure" xsd:string {external_ontology="FMA"}
@@ -190723,7 +190627,7 @@ xref: Wikipedia:Limbus_laminae_spiralis
is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0001855 {source="MA"} ! cochlear duct of membranous labyrinth
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray930.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray930.png" xsd:anyURI
[Term]
id: UBERON:0002278
@@ -190773,7 +190677,7 @@ xref: Wikipedia:Stria_vascularis
is_a: UBERON:0000064 ! organ part
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
relationship: part_of UBERON:0001855 {source="FMA", source="MA"} ! cochlear duct of membranous labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c7/Cochlea-crosssection.png" xsd:anyURI
property_value: UBPROP:0000012 "represented as a wall in FMA. MESH def implies part of spiral ligament but better represented as adjacency / overlaps" xsd:string {external_ontology="FMA"}
[Term]
@@ -190831,7 +190735,7 @@ relationship: part_of UBERON:0001869 {gci_relation="part_of", gci_filler="NCBITa
relationship: part_of UBERON:0001893 ! telencephalon
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: transformation_of UBERON:0009676 {notes="material to immaterial", source="EHDAA2"} ! early telencephalic vesicle
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
property_value: UBPROP:0000001 "The lateral ventricles are part of the ventricular system of the brain. Classified as part of the telencephalon, they are the largest of the ventricles. The lateral ventricles connect to the central third ventricle through the interventricular foramina of Monro[WP]." xsd:string {source="Wikipedia:Lateral_ventricle"}
property_value: UBPROP:0000001 "The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle[GO]." xsd:string {source="GO:0021670"}
property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000643", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"}
@@ -190913,7 +190817,7 @@ relationship: has_part UBERON:0001359 ! cerebrospinal fluid
relationship: part_of UBERON:0002240 {source="MA"} ! spinal cord
relationship: part_of UBERON:0005281 {source="FMA"} ! ventricular system of central nervous system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Medulla_spinalis_-_Section_-_English.svg" xsd:anyURI
[Term]
id: UBERON:0002294
@@ -190948,7 +190852,7 @@ relationship: capable_of GO:0006699 ! bile acid biosynthetic process
relationship: capable_of GO:0015721 ! bile acid and bile salt transport
relationship: has_part UBERON:0001173 ! biliary tree
relationship: part_of UBERON:0002423 ! hepatobiliary system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
property_value: RO:0002171 UBERON:0016478
[Term]
@@ -190969,7 +190873,7 @@ is_a: UBERON:0011060 {source="MA"} ! perilymphatic channel
is_a: UBERON:0013685 ! foramen of skull
relationship: contributes_to_morphology_of UBERON:0001844 ! cochlea
relationship: part_of UBERON:0001844 {source="FMA"} ! cochlea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bc/Gray928.png" xsd:anyURI
property_value: editor_note "TODO - check cochlear duct vs cochlear aqueduct vs scala media" xsd:string
[Term]
@@ -190996,7 +190900,7 @@ xref: ZFA:0005130
is_a: UBERON:0006598 ! presumptive structure
relationship: has_potential_to_develop_into UBERON:0002095 ! mesentery
relationship: part_of UBERON:0009664 {source="EHDAA2"} ! gut mesentery
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray985.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray985.png" xsd:anyURI
property_value: UBPROP:0000001 "The mesentery that originates from the dorsal side of the peritoneal cavity.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005130", ontology="TAO", source="ZFIN:curator"}
[Term]
@@ -191041,7 +190945,7 @@ relationship: continuous_with UBERON:0002240 ! spinal cord
relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: has_part UBERON:0001896 ! medulla oblongata
relationship: has_part UBERON:0001943 ! midbrain tegmentum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001890 {notes="we apply a strict definition"}
property_value: RO:0002171 UBERON:0002037 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0002314 {notes="we apply a strict definition"}
@@ -191087,7 +190991,7 @@ relationship: only_in_taxon NCBITaxon:40674 {source="PMID:12625309", source="PMI
relationship: part_of UBERON:0006524 {source="MA"} ! alveolar system
relationship: part_of UBERON:0008874 ! pulmonary acinus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/46/Alveolus_diagram.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/46/Alveolus_diagram.svg" xsd:anyURI
[Term]
id: UBERON:0002301
@@ -191314,7 +191218,7 @@ is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: part_of UBERON:0000052 {notes="Need to determine whether the fimbria is part of the fornix. Sometimes the language suggests it isn't always thought of that way, but I see no useful reason why it should be separate; it all forms one continuous white matter tract. Neuronames and others include this as part of the hippocampal formation (MM)", source="NIFSTD"} ! fornix of brain
relationship: part_of UBERON:0001954 {source="MA", source="NIFSTD"} ! Ammon's horn
relationship: part_of UBERON:0011299 ! white matter of telencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray749.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Gray749.png" xsd:anyURI
[Term]
id: UBERON:0002313
@@ -191387,7 +191291,7 @@ xref: Wikipedia:Midbrain_tectum
is_a: UBERON:0002616 ! regional part of brain
relationship: develops_from UBERON:0005882 {source="Wikipedia"} ! neural tube alar plate
relationship: part_of UBERON:0001891 ! midbrain
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray685.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray685.png" xsd:anyURI
property_value: UBPROP:0000003 "The tectum - a multisensory, topologically mapped structure in the roof of the midbrain presents a remarkable degree of conservation in all vertebrate radiations; although it varies in the extent of its development in different vertebrate classes, there is considerable evidence now to deem its layered structure, its cell types, and its hodological pattern as homologous in all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001388", ontology="VHOG", source="DOI:10.1371/journal.pone.0003582 Maximino C, Evolutionary Changes in the Complexity of the Tectum of Nontetrapods: A Cladistic Approach. PLoS ONE (2008)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "In adult humans it is present only in the mesencephalon as the inferior and the superior colliculi" xsd:string {source="WP"}
@@ -191457,8 +191361,8 @@ xref: Wikipedia:White_matter
xref: ZFA:0001682
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: composed_primarily_of UBERON:0006135 ! myelinated nerve fiber
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929]." xsd:string {source="FMA:83929"}
property_value: UBPROP:0000001 "Multi-tissue structure comprised largely of myelinated axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002142", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001764", ontology="VHOG", source="DOI:10.1038/nature09614 Nave KA, Myelination and support of axonal integrity by glia. Nature (2010)", source="http://bgee.unil.ch/"}
@@ -191732,7 +191636,7 @@ relationship: part_of UBERON:0000922 {gci_relation="part_of", gci_filler="NCBITa
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -191781,7 +191685,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -191857,7 +191761,7 @@ relationship: connects UBERON:0000922 ! embryo
relationship: connects UBERON:0001987 ! placenta
relationship: develops_from UBERON:0007806 ! connecting stalk
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Umbilicalcord.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Umbilicalcord.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb" xsd:string
property_value: UBPROP:0000001 "The connecting cord from the developing embryo or fetus to the placenta. During prenatal development, the umbilical cord comes from the same zygote as the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta.property_value, external_definition the umbilical arteries return the deoxygenated, nutrient-depleted blood[WP]." xsd:string {source="Wikipedia:Umbilical_cord"}
property_value: UBPROP:0000007 "umbilical" xsd:string
@@ -191888,7 +191792,7 @@ relationship: continuous_with UBERON:0000948 ! heart
relationship: continuous_with UBERON:0002080 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! heart right ventricle
relationship: part_of UBERON:0008886 ! pulmonary vascular system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
property_value: UBPROP:0000001 "An arterial trunk with origin from the right ventricle of the heart, and dividing into the right and left pulmonary arteries, which enter the corresponding lungs and branch with the bronchi. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001134", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pulmonary+trunk"}
@@ -192071,8 +191975,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -192191,7 +192095,7 @@ intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
relationship: develops_from UBERON:0013507 ! thoracic vertebra cartilage element
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray90.png" xsd:anyURI
property_value: UBPROP:0000008 "Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, they are distinguished by the presence of facets on the sides of the bodies for articulation with the heads of the ribs, and facets on the transverse processes of all, except the eleventh and twelfth, for articulation with the tubercles of the ribs" xsd:string
[Term]
@@ -192272,7 +192176,7 @@ intersection_of: composed_primarily_of UBERON:0001133 ! cardiac muscle tissue
relationship: composed_primarily_of UBERON:0001133 ! cardiac muscle tissue
relationship: has_part UBERON:0002350 ! conducting system of heart
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg" xsd:anyURI
property_value: editor_note "TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium" xsd:string
property_value: UBPROP:0000001 "Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000083", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "The middle layer of the heart, consisting of cardiac muscle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010410", ontology="AAO", source="AAO:BJB"}
@@ -192361,8 +192265,8 @@ relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0002350 {source="ZFA"} ! conducting system of heart
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Sinoatrial_node_low_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/de/Sinoatrial_node_2_low_mag.jpg" xsd:anyURI
[Term]
id: UBERON:0002352
@@ -192409,8 +192313,8 @@ relationship: connected_to UBERON:0005979 ! crista terminalis
relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart
relationship: part_of UBERON:0002350 ! conducting system of heart
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/92/Gray501.png" xsd:anyURI
property_value: UBPROP:0000003 "Three major adaptations, or 'novel cardiac components', that were not present in the ancestor chordate heart tube can be distinguished in the lower vertebrate heart: the atrium, ventricle, and possibly the muscular sinus venosus. Furthermore, within the ventricular component a compact outer myocardial component and an interiorly localized extensive trabecular component can be distinguished. The specific activation of the ventricle adds to its complexity as follows. The depolarizing impulse travels rapidly from the atrioventricular node toward the apex and then toward the conal region, achieving activation from apex to base.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001474", ontology="VHOG", source="DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003)", source="http://bgee.unil.ch/"}
[Term]
@@ -192447,8 +192351,8 @@ relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of
relationship: has_part CL:1000410 {source="FMA"} ! myocyte of atrioventricular node
relationship: part_of UBERON:0004146 {source="GO"} ! His-Purkinje system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b6/ECG_Principle_fast.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b6/ECG_Principle_fast.gif" xsd:anyURI
[Term]
id: UBERON:0002354
@@ -192477,7 +192381,7 @@ is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: contributes_to_morphology_of UBERON:0002350 ! conducting system of heart
relationship: has_part CL:0002068 {source="FMA"} ! Purkinje myocyte
relationship: part_of UBERON:8000009 {source="https://github.com/obophenotype/uberon/issues/1785", source="https://orcid.org/0000-0001-5208-3432", source="https://orcid.org/0000-0002-9791-0064"} ! Purkinje fiber network
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray498.png" xsd:anyURI
[Term]
id: UBERON:0002355
@@ -192561,7 +192465,7 @@ intersection_of: UBERON:0000042 ! serous membrane
intersection_of: part_of UBERON:0035820 ! peritoneal sac
relationship: part_of UBERON:0003697 {source="MP"} ! abdominal wall
relationship: part_of UBERON:0035820 ! peritoneal sac
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray1040.png" xsd:anyURI
property_value: editor_note "TODO - in ZFA is_a epithelium" xsd:string
property_value: UBPROP:0000001 "An epithelium that lines the peritoneal cavity.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005120", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Serous membrane that forms the lining of the abdominal cavity or the coelom. It covers most of the intra-abdominal organs, supports the abdominal organs, and serves as a conduit for their blood and lymph vessels and nerves. It is composed of a layer of mesothelium.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010814", ontology="AAO", source="AAO:JMG"}
@@ -192623,7 +192527,7 @@ is_a: UBERON:0000094 {source="FMA"} ! membrane organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: immediate_transformation_of UBERON:0007645 {source="Bgee:AN"} ! future meninx
relationship: part_of UBERON:0010743 ! meningeal cluster
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/48/Illu_meninges.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/48/Illu_meninges.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Membrane covering the brain and spinal cord. It is represented by a single layer in fishes, two in amphibians, reptiles and birds and three in mammals (named dura mater, arachnoid and pia mater). [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001295", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/meninges"}
property_value: UBPROP:0000003 "In fishes, the meninges consist of a single membrane, the primitive meninx, wrapped around the brain and spinal cord. With the adoption of terrestrial life, the meninges doubled. In amphibians, reptiles, and birds, the meninges include a thick outer dura mater derived from mesoderm and a thin inner secondary meninx. (...) In mammals, the dura mater persists, but division of the secondary meninx yields both the arachnoid and the pia mater from ectomesoderm.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001295", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "meningeal" xsd:string
@@ -192670,8 +192574,8 @@ xref: Wikipedia:Pia_mater
is_a: UBERON:0000391 ! leptomeninx
relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue
relationship: only_in_taxon NCBITaxon:40674 {notes="check-aves", source="ISBN:0073040584"} ! Mammalia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray770-en.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray770.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/31/Gray770-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray770.png" xsd:anyURI
property_value: editor_note "consider adding adjacency relationship to neuraxis (brain+spinal cord); however note that at this time the meninges may be considered part of the nervous system" xsd:string
property_value: UBPROP:0000001 "delicate innermost layer of the meninges-the membranes surrounding the brain and spinal cord. The thin, mesh-like pia mater closely envelops the entire surface of the brain, running down into the fissures of the cortex. It joins with the ependyma which lines the ventricles to form choroid plexuses that produce cerebrospinal fluid. In the spinal cord, the pia mater attaches to the dura mater by the denticular ligaments through the arachnoid membrane. The pia mater is a neural crest derivative[Wikipedia:Pia_mater]." xsd:string {source="Wikipedia:Pia_mater"}
@@ -192703,7 +192607,7 @@ xref: Wikipedia:Arachnoid_mater
is_a: UBERON:0000391 ! leptomeninx
relationship: composed_primarily_of GO:0071953 ! elastic fiber
relationship: only_in_taxon NCBITaxon:40674 {source="ISBN:0073040584"} ! Mammalia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a0/Gray767.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a0/Gray767.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002049 {source="ISBN:0471888893"}
[Term]
@@ -192735,7 +192639,7 @@ is_a: UBERON:0002360 ! meninx
relationship: continuous_with UBERON:0001773 {source="PMID:16496288"} ! sclera
relationship: immediate_transformation_of UBERON:0007647 {evidence="definitional"} ! ectomeninx
relationship: never_in_taxon NCBITaxon:32443 {source="ISBN:0073040584"} ! Teleostei
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Meninges-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Meninges-en.svg" xsd:anyURI
property_value: UBPROP:0000001 "the outermost of the three layers of the meninges surrounding the brain and spinal cord. The other two meningeal layers are the pia mater and the arachnoid mater. The dura surrounds the brain and the spinal cord and is responsible for keeping in the cerebrospinal fluid[Wikipedia:Dura_mater]." xsd:string {source="Wikipedia:Dura_mater"}
property_value: UBPROP:0000009 "capable of inducing chondrogenesis - requires contact with an epithelium - http://www.ncbi.nlm.nih.gov/pubmed/16496288" xsd:string
property_value: UBPROP:0000012 "some ontologies consider dura mater part of the CNS, others dispute this and claim it surrounds it (e.g. DOI:10.1111/joa.12381)[https://github.com/obophenotype/uberon/issues/1261]" xsd:string
@@ -192850,7 +192754,7 @@ is_a: UBERON:0010147 ! male accessory sex gland
relationship: develops_from UBERON:0003820 ! prostate bud
relationship: only_in_taxon NCBITaxon:40674 {source="Wikipedia"} ! Mammalia
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Prostatelead.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Prostatelead.jpg" xsd:anyURI
property_value: editor_note "TODO - FMA treats the gland as part of the prostate - see also FMA:74119." xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb" xsd:string
property_value: UBPROP:0000007 "prostatic" xsd:string
@@ -192885,7 +192789,7 @@ intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000949 ! endocrine system
relationship: capable_of GO:0046879 ! hormone secretion
relationship: part_of UBERON:0000949 ! endocrine system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI
[Term]
id: UBERON:0002369
@@ -192932,8 +192836,8 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
is_a: UBERON:0015212 ! lateral structure
relationship: has_developmental_contribution_from UBERON:0000926 {source="Wikipedia"} ! mesoderm
relationship: in_lateral_side_of UBERON:0000949 {source="FMA-abduced-lr"} ! endocrine system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9d/Illu_endocrine_system_New.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Illu_endocrine_system.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical structure which is found on the surface of the kidney and secretes various hormones including epinephrine, norephinephrine, aldosterone, corticosterone, and cortisol.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010551", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001141", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "The origin of the adrenal gland is still controversial. It is thought to share the same origin as the kidney and gonads, derived from coelomic epithelium of the urogenital ridge and/or the underlying mesenchyme (Keegan and Hammer, 2002; Morohashi, 1997). We follow Kardong and state homology at the level of the cortex and medulla rather than gland as a whole" xsd:string
@@ -192988,7 +192892,7 @@ relationship: has_part UBERON:0003846 ! thymus epithelium
relationship: only_in_taxon NCBITaxon:7776 {source="multiple sources - true thymus appears in jawed vertebrates"} ! Gnathostomata
relationship: part_of UBERON:0000153 ! anterior region of body
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cf/Illu_thymus.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cf/Illu_thymus.jpg" xsd:anyURI
property_value: editor_note "check - a subtype of gland? not in GO. NCIT has thymus and thymus gland. EHDAA2 has ductless gland." xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Thymus.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Thymus.glb" xsd:string
@@ -193040,7 +192944,7 @@ relationship: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0002390 {source="FMA", source="MA"} ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string
property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string
property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"}
@@ -193105,7 +193009,7 @@ intersection_of: part_of UBERON:0004453 ! metacarpus region
relationship: connected_to UBERON:0001435 ! carpal bone
relationship: connected_to UBERON:0001436 ! phalanx of manus
relationship: part_of UBERON:0010544 ! metacarpus skeleton
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI
[Term]
id: UBERON:0002376
@@ -193235,7 +193139,7 @@ relationship: has_muscle_insertion UBERON:0007173 {notes="posterior border of th
relationship: has_muscle_origin UBERON:0000351 {notes="external occipital protuberance nuchal ligament medial superior nuchal line spinous processes of vertebrae C7-T12", source="dbpedia"} ! nuchal ligament
relationship: has_muscle_origin UBERON:0001076 {notes="external occipital protuberance nuchal ligament medial superior nuchal line spinous processes of vertebrae C7-T12", source="dbpedia"} ! neural spine
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/60/Trapezius.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/60/Trapezius.png" xsd:anyURI
property_value: UBPROP:0000003 "The sternomastoid and the three parts of the trapezius are branchiomeric muscles that have secondarily acquired an attachment to the pectoral girdle. They evolved from the fish cucullaris.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000834", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.345", source="http://bgee.unil.ch/"}
[Term]
@@ -193269,7 +193173,7 @@ relationship: has_muscle_origin UBERON:0001105 {notes="anterior surface of the m
relationship: innervated_by UBERON:0003726 {notes="lateral pectoral nerve and medial pectoral nerveClavicular head: C5 and C6Sternocostal head: C7 C8 and T1", source="dbpedia"} ! thoracic nerve
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: superficial_to UBERON:0001100 ! pectoralis minor
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/6c/Pectoralis_major.png" xsd:anyURI
[Term]
id: UBERON:0002384
@@ -193403,8 +193307,8 @@ intersection_of: UBERON:0002471 ! zeugopod
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: has_skeleton UBERON:0010703 ! forelimb zeugopod skeleton
relationship: part_of UBERON:0001460 {source="MA"} ! arm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Veins.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Veins.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/50/Forearm_labeled.png" xsd:anyURI
property_value: UBPROP:0000001 "The middle forelimb region. [Evolution, Fourth_Edition_(2006)_Boston_etc.:_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.321, see_Kardong_KV][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000341", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000341", ontology="VHOG", source="ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000013 "Naming conventions for pod terms under discussion within phenoscape group. TODO - add distinct term for skeleton and place AAO class here" xsd:string
@@ -193452,7 +193356,7 @@ intersection_of: UBERON:0002470 ! autopod region
intersection_of: part_of UBERON:0002103 ! hindlimb
relationship: develops_from UBERON:0006871 ! embryonic footplate
relationship: has_skeleton UBERON:0001445 ! skeleton of pes
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ae/Male_Right_Foot_1.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ae/Male_Right_Foot_1.jpg" xsd:anyURI
property_value: UBPROP:0000007 "pedal" xsd:string
[Term]
@@ -193574,7 +193478,7 @@ xref: ZFA:0005658
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system
relationship: transformation_of UBERON:0000913 ! interstitial fluid
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Illu_lymph_capillary.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Illu_lymph_capillary.png" xsd:anyURI
[Term]
id: UBERON:0002392
@@ -193610,7 +193514,7 @@ relationship: develops_from UBERON:0006266 ! nasolacrimal groove
relationship: has_part CL:0000160 ! goblet cell
relationship: has_part UBERON:0007602 ! stratified columnar epithelium
relationship: part_of UBERON:0001850 ! lacrimal drainage system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray896.png" xsd:anyURI
property_value: UBPROP:0000003 "The nasolacrimal duct is probably homologous to the posterior (excurrent) naris of actinopterygian fishes.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000664", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.256", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000010 "the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue" xsd:string
@@ -193652,7 +193556,7 @@ relationship: channel_for UBERON:0001970 ! bile
relationship: contributes_to_morphology_of UBERON:0001173 ! biliary tree
relationship: develops_from UBERON:0008835 {source="XAO"} ! hepatic diverticulum
relationship: part_of UBERON:0001173 {source="EMAPA", source="MA"} ! biliary tree
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5d/Digestive_system_showing_bile_duct.png" xsd:anyURI
property_value: UBPROP:0000001 "A duct that carries bile from the liver to the intestine." xsd:string {source="ZFA:0001100, ZFA:curator"}
property_value: UBPROP:0000001 "Any of the excretory ducts in the liver that convey bile between the liver and the intestine. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000212", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/bile+duct"}
property_value: UBPROP:0000003 "(...) the amphibian liver has characteristics in common with both fish and terrestrial vertebrates. (...) The histological structure of the liver is similar to that in other vertebrates, with hepatocytes arranged in clusters and cords separated by a meshwork of sinusoids and the presence of the traditional triad of portal venule, hepatic arteriole, and bile duct.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000212", ontology="VHOG", source="DOI:10.1053/ax.2000.7133 Crawshaw GJ, Weinkle TK, Clinical and pathological aspects of the amphibian liver. Seminars in Avian and Exotic Pet Medicine (2000)", source="http://bgee.unil.ch/"}
@@ -193687,7 +193591,7 @@ relationship: connected_to UBERON:0001679 {gci_relation="part_of", gci_filler="N
relationship: contributes_to_morphology_of UBERON:0011156 ! facial skeleton
relationship: part_of UBERON:0011085 ! palatoquadrate arch
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Dermal bone that underlies the mesethmoid and inserts in a fossa on the anteroventral surface of the parasphenoid.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000308", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Paired, palatal bones of intramembranous origin that lie ventral to the olfactory region and help to floor the nasal capsules.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000633", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: overlaps autopalatine-vomer joint (TAO:0001784)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000308", ontology="TAO"}
@@ -193736,7 +193640,7 @@ intersection_of: UBERON:0002470 ! autopod region
intersection_of: part_of UBERON:0002102 ! forelimb
relationship: develops_from UBERON:0006875 ! embryonic handplate
relationship: has_skeleton UBERON:0001442 ! skeleton of manus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/76/LeftHand0.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/76/LeftHand0.jpg" xsd:anyURI
property_value: IAO:0000232 "like all limb segments, this class encompasses both the unformed hand region of the embryo to the fully formed structure complete with skeleton" xsd:string
property_value: UBPROP:0000007 "manual" xsd:string
@@ -193832,7 +193736,7 @@ relationship: adjacent_to UBERON:0002400 ! parietal pleura
relationship: adjacent_to UBERON:0002401 ! visceral pleura
relationship: develops_from UBERON:0003887 {source="Wikipedia"} ! intraembryonic coelom
relationship: luminal_space_of UBERON:0009778 ! pleural sac
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI
property_value: UBPROP:0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart [of other tetrapods] is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000581", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000009 "The contraction of the diaphragm creates a negative pressure within the pleural cavity which forces the lungs to expand resulting in passive exhalation and active inhalation. This breathing process can be made forceful through the contraction of the external intercostal muscles which forces the rib cage to expand and add to the negative pressure in the pleural cavity causing the lungs to fill with air. The fluid in the cavity provides lubrication and cushioning" xsd:string
property_value: UBPROP:0000012 "the EHDAA2 class of the same is not equivalent. See https://github.com/obophenotype/uberon/issues/86" xsd:string {external_ontology="EHDAA2"}
@@ -193893,7 +193797,7 @@ relationship: has_part UBERON:0001074 ! pericardial cavity
relationship: has_part UBERON:0002357 ! serous pericardium
relationship: part_of UBERON:0002407 ! pericardium
relationship: surrounded_by UBERON:0002359 {source="FMA"} ! fibrous pericardium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI
[Term]
id: UBERON:0002407
@@ -193933,7 +193837,7 @@ relationship: has_part UBERON:0002359 ! fibrous pericardium
relationship: has_part UBERON:0002406 ! pericardial sac
relationship: part_of UBERON:0015410 {source="MA"} ! heart plus pericardium
relationship: surrounds UBERON:0002349 ! myocardium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI
property_value: UBPROP:0000001 "Peritoneum that surrounds the heart.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010817", ontology="AAO", source="AAO:JMG"}
property_value: UBPROP:0000007 "pericardial" xsd:string
property_value: UBPROP:0000012 "In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity" xsd:string {external_ontology="FMA"}
@@ -193967,7 +193871,7 @@ intersection_of: UBERON:0022351 ! parietal serous membrane
intersection_of: part_of UBERON:0002357 ! serous pericardium
relationship: attaches_to UBERON:0006670 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! central tendon of diaphragm
relationship: part_of UBERON:0002357 ! serous pericardium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png" xsd:anyURI
[Term]
id: UBERON:0002409
@@ -194028,7 +193932,7 @@ is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0000010 {source="EMAPA", source="MA", source="NIFSTD", source="ZFA-modified-from-isa"} ! peripheral nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray839.png" xsd:anyURI
property_value: UBPROP:0000001 "Nervous system including a portion of the central and peripheral systems and presiding over the control and coordination of the vegetative functions of the organism. It innervates smooth and cardiac muscles and glandular tissues and is responsible for many actions which are more or less automatic (e.g. secretion, vasoconstriction etc.). It consists of the sympathetic and parasympathetic nervous systems. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000396", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Part of the peripheral nervous system which regulates involuntary functions of the body and consists of the sympathetic and parasympathetic system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000033", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "From comparative analyses of craniate brains, a morphotype of the brain in the earliest craniate stock can be constructed. In marked contrast to cephalochordates, the ancestral craniate morphotype had a plethora of unique features, which included a telencephalon with pallial and subpallial parts, paired olfactory bulbs with substantial projections to most or all of the telencephalic pallium, paired lateral eyes and ears, a lateral line system for both electroreception and mechanoreception, spinal cord dorsal root ganglia, and an autonomic nervous system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000396", ontology="VHOG", source="DOI:10.1002/1097-0185(20000615)261:3<111::AID-AR6>3.0.CO;2-F Butler AB, Chordate evolution and the origin of craniates: An old brain in a new head. AnaT Rec (New Anat) (2000)", source="http://bgee.unil.ch/"}
@@ -194062,7 +193966,7 @@ relationship: contributes_to_morphology_of UBERON:0005056 ! external female geni
relationship: develops_from UBERON:0005876 {source="EHDAA2", source="Wikipedia"} ! undifferentiated genital tubercle
relationship: only_in_taxon NCBITaxon:40674 {source="Wikipedia"} ! Mammalia
relationship: part_of UBERON:0000997 {source="MA"} ! mammalian vulva
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Clitoris_anatomy_labeled-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Clitoris_anatomy_labeled-en.svg" xsd:anyURI
property_value: UBPROP:0000007 "clitoral" xsd:string
[Term]
@@ -194130,7 +194034,7 @@ intersection_of: UBERON:0015007 ! cervical vertebra endochondral element
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
relationship: develops_from UBERON:0013505 ! cervical vertebra cartilage element
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Illu_vertebral_column.jpg" xsd:anyURI
property_value: UBPROP:0000008 "In some species, some parts of the skull may be composed of vertebra-like elements, e.g. the occipital bone in humans is composed of four vertebra-like segments. In many vertebrate species, cervical vertebrae are variable in number; however, almost all mammals have seven (including those with very short necks relative to body size, such as elephants or whales, and those with very long necks, such as giraffes). The few exceptions include the manatee and the sloths, of which the two-toed sloth has six cervical vertebrae and the three-toed sloth has up to nine cervical vertebrae. In many species, though not in mammals, the cervical vertebrae bear ribs. In many other groups, such as lizards and saurischian dinosaurs, the cervical ribs are large; in birds they are small and completely fused to the vertebrae. The transverse processes of mammals are homologous to the cervical ribs of other amniotes. Thoracic vertebrae in all species are defined as those vertebrae which also carry a pair of ribs, and lie caudal to the cervical vertebrae. In humans, cervical vertebrae are the smallest of the true vertebrae, and can be readily distinguished from those of the thoracic or lumbar regions by the presence of a foramen (hole) in each transverse process, through which passes the vertebral artery." xsd:string
[Term]
@@ -194275,7 +194179,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: has_part CHEBI:18085
relationship: has_part CL:0000138 ! chondrocyte
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI
property_value: UBPROP:0000001 "A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000060", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000001 "Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001501", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000040", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"}
@@ -194324,7 +194228,7 @@ xref: SCTID:244434001
is_a: UBERON:0003528 ! brain gray matter
is_a: UBERON:0007245 {source="FMA"} ! nuclear complex of neuraxis
relationship: part_of UBERON:0010011 ! collection of basal ganglia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Basal_Ganglia_and_Related_Structures.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1b/Basal_Ganglia_and_Related_Structures.svg" xsd:anyURI
property_value: editor_note "it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the set of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done." xsd:string
[Term]
@@ -194420,7 +194324,7 @@ relationship: contributes_to_morphology_of UBERON:0002028 ! hindbrain
relationship: develops_from UBERON:0013149 {source="EHDAA2"} ! hindbrain vesicle
relationship: part_of UBERON:0002028 ! hindbrain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
property_value: UBPROP:0000001 "Fluid-filled brain cavity. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000110", ontology="TAO", source="ZFIN:curator"}
@@ -194621,7 +194525,7 @@ is_a: UBERON:0000029 ! lymph node
intersection_of: UBERON:0000029 ! lymph node
intersection_of: part_of UBERON:0000974 ! neck
relationship: part_of UBERON:0000974 ! neck
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Lymph_node_regions.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Lymph_node_regions.jpg" xsd:anyURI
[Term]
id: UBERON:0002435
@@ -194667,7 +194571,7 @@ relationship: contributes_to_morphology_of UBERON:0010011 ! collection of basal
relationship: part_of UBERON:0000204 {source="GO"} ! ventral part of telencephalon
relationship: part_of UBERON:0000369 {source="BTO"} ! corpus striatum
relationship: part_of UBERON:0006098 {source="NIFSTD"} ! basal nuclear complex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0006514 {source="ABA"}
property_value: UBPROP:0000007 "striatal" xsd:string
property_value: UBPROP:0000012 "FMA divides 'striatum of neuraxis' into 4, neostriatum is seperate class. In NIF these are synonyms. TODO - check striatum vs corpus striatum see Wikipedia:Striatum#History. Check caudoputamen" xsd:string {external_ontology="FMA"}
@@ -194815,7 +194719,7 @@ relationship: adjacent_to UBERON:0001485 ! knee joint
relationship: connected_to UBERON:0000981 ! femur
relationship: part_of UBERON:0001465 ! knee
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
property_value: UBPROP:0000007 "patellar" xsd:string
[Term]
@@ -194854,7 +194758,7 @@ relationship: contributes_to_morphology_of UBERON:0001987 ! placenta
relationship: develops_from UBERON:0000459 ! uterine wall
relationship: part_of UBERON:0001987 {component="maternal", source="MA"} ! placenta
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray33.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray33.png" xsd:anyURI
property_value: editor_note "TODO - check mp syn" xsd:string
property_value: UBPROP:0000011 "formed under the influence of progesterone and forms highly-characteristic cells. [Wikipedia:Decidua]" xsd:string
@@ -194889,7 +194793,7 @@ intersection_of: part_of UBERON:0001295 ! endometrium
relationship: has_quality PATO:0002299 {source="Wikipedia:Tubular_gland"} ! tubular
relationship: part_of UBERON:0012276 ! endometrium glandular epithelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray1169.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray1169.png" xsd:anyURI
property_value: UBPROP:0000010 "simple or branched tubular" xsd:string
property_value: UBPROP:0000202 FMA:71647
@@ -194920,7 +194824,7 @@ relationship: branching_part_of UBERON:0001533 ! subclavian artery
relationship: part_of UBERON:0001533 ! subclavian artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0000310 ! breast
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray522.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray522.png" xsd:anyURI
property_value: UBPROP:0000012 "MA has both mammary and thoracic" xsd:string {external_ontology="MA"}
[Term]
@@ -194990,7 +194894,7 @@ intersection_of: drains UBERON:0001255 ! urinary bladder
relationship: drains UBERON:0001255 ! urinary bladder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: tributary_of UBERON:0001317 ! internal iliac vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI
property_value: UBPROP:0000202 FMA:70911
[Term]
@@ -195049,7 +194953,7 @@ is_a: UBERON:0000467 ! anatomical system
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0002193 {source="FMA"} ! hemolymphoid system
relationship: part_of UBERON:0002405 ! immune system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/TE-Lymphatic_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/TE-Lymphatic_system_diagram.svg" xsd:anyURI
property_value: UBPROP:0000001 "Part of the circulatory system which consists of a series of vessels which collect blood (exclusive of erythrocytes) which seep through capillary walls and return it to the veins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010522", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Tetrapods have evolved distinct lymphatic systems, in which lymphatic capillaries help drain most of the tissues of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000842", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.627", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "lymphoid" xsd:string
@@ -195254,7 +195158,7 @@ relationship: develops_from UBERON:0005687 ! orbitosphenoid cartilage element
relationship: develops_from UBERON:0009638 ! orbitosphenoid ossification center
relationship: in_lateral_side_of UBERON:0002517 {source="FMA-abduced-lr"} ! basicranium
relationship: part_of UBERON:0001677 ! sphenoid bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png" xsd:anyURI
property_value: UBPROP:0000001 "Endochondral ossification of the lateral sides of the braincase.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000345", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000001 "Large median unpaired cartilage bone consisting of two diverging plates. Positioned medial to the eye. The orbitosphenoid develops from the Trabeculae communis and forms the anterior and anterolateral boundary of the orbital foramen and constitutes a significant part of the sidewalls and floor of the cranial cavity. Bordered by the lateral ethmoid anteriorly, and the pterosphenoid posteriorly, The orbitosphenoid may extend ventrally to meet the parasphenoid. In the adult, the orbitosphenoid is fused ventrally to the parasphenoid via a thin sheet of bone.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000253", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000002 "relationship loss: develops_from taenia marginalis anterior (TAO:0001505)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000253", ontology="TAO"}
@@ -195415,8 +195319,8 @@ is_a: UBERON:0003685 ! cranial suture
intersection_of: UBERON:0003685 ! cranial suture
intersection_of: connects UBERON:0000209 {cardinality="2"} ! tetrapod frontal bone
relationship: connects UBERON:0000209 {notes="two halves of the frontal bone"} ! tetrapod frontal bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray134.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d1/Frontal_suture.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray134.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d1/Frontal_suture.png" xsd:anyURI
property_value: UBPROP:0000008 "in humans, the frontal suture is a dense connective tissue structure that divides the two halves of the frontal bone of the skull in infants and children. It usually disappears by the age of six, with the two halves of the frontal bone being fused together. If it does not disappear it may be called a 'metopic suture' or 'sutura frontalis persistens. ' If the suture is not present at birth (craniosynostosis) it will cause a keel-shaped deformity of the skull called 'trigonocephaly. ' It is present in a fetal skull so that the skull can bend and is very elastic at the time of birth. The baby's head literally bends when coming out of the mother's womb. The space is filled as the child grows older. [WP,unvetted]" xsd:string
[Term]
@@ -195465,7 +195369,7 @@ xref: VSAO:0005067
xref: Wikipedia:Acromion
is_a: UBERON:0004530 ! bony projection
relationship: part_of UBERON:0006849 ! scapula
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/79/Gray206.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/79/Gray206.png" xsd:anyURI
property_value: UBPROP:0000001 "Anterior rounded projection of the pars acromialis of the scapula.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000826", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: part_of pars acromialis (AAO:0000752)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000826", ontology="AAO"}
@@ -195497,7 +195401,7 @@ is_a: UBERON:0005813 ! tubercle
is_a: UBERON:4100000 ! skeletal element projection
relationship: contributes_to_morphology_of UBERON:0000976 ! humerus
relationship: part_of UBERON:0004652 ! humerus diaphysis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/HumerusFront.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a7/HumerusFront.png" xsd:anyURI
property_value: UBPROP:0000008 "In basal Tetrapodomorph lineages often the deltoid process and the pectoral processes are separate and thus should not be made exact synonyms to the deltopectoral crest.[PHENOSCAPE:ad]" xsd:string
[Term]
@@ -195517,7 +195421,7 @@ xref: Wikipedia:Cochlear_labyrinth
is_a: UBERON:0000064 ! organ part
relationship: located_in UBERON:0001844 ! cochlea
relationship: part_of UBERON:0001849 {source="FMA"} ! membranous labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI
property_value: editor_note "we follow the FMA in placing this in the membranous labyrinth. Notes: The labyrinth can be divided by layer or by region. Bony vs. membranous / Vestibular vs. cochlear" xsd:string
[Term]
@@ -195648,7 +195552,7 @@ relationship: only_in_taxon NCBITaxon:40674 {source="Wikipedia"} ! Mammalia
relationship: part_of UBERON:0000992 {source="MA"} ! ovary
relationship: present_in_taxon NCBITaxon:7762 {source="PMID:20959416"}
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/57/Folliclesinovary.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/57/Folliclesinovary.jpg" xsd:anyURI
property_value: UBPROP:0000008 "maintains the endometrium in mammals[WP]. A corpus luteum is known in hagfish (100), Squalus (101), and salamander (100) but not lamprey (102). There are no data for Branchiostoma and Ciona, and given that they are multiple spawners, there is no a priori reason to conclude that they lack a corpus luteum" xsd:string {source="PMID:20959416"}
[Term]
@@ -195676,7 +195580,7 @@ intersection_of: UBERON:0001474 ! bone element
intersection_of: develops_from UBERON:0005863 ! cartilaginous condensation
relationship: developmentally_replaces UBERON:0002418 ! cartilage tissue
relationship: develops_from UBERON:0007844 {source="VSAO"} ! cartilage element
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Hypertrophic_Zone_of_Epiphyseal_Plate.jpg" xsd:anyURI
property_value: editor_note "placement in this class to be inferred" xsd:string
property_value: seeAlso "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" xsd:anyURI
property_value: UBPROP:0000001 "Replacement bone that forms within cartilage.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000145", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"}
@@ -195721,7 +195625,7 @@ is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000158 ! membranous layer
relationship: composed_primarily_of UBERON:0011822 ! dense irregular connective tissue
relationship: part_of UBERON:0001474 ! bone element
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cf/Bone_growth.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cf/Bone_growth.png" xsd:anyURI
property_value: UBPROP:0000007 "periosteal" xsd:string
[Term]
@@ -195748,7 +195652,7 @@ is_a: UBERON:0000075 ! subdivision of skeletal system
relationship: contributes_to_morphology_of UBERON:0003128 ! cranium
relationship: part_of UBERON:0001703 ! neurocranium
relationship: part_of UBERON:0002241 ! chondrocranium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png" xsd:anyURI
property_value: UBPROP:0000007 "basicranial" xsd:string
[Term]
@@ -195776,7 +195680,7 @@ is_a: UBERON:0006585 ! vestibular organ
relationship: capable_of_part_of GO:0060007 ! linear vestibuloocular reflex
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0001862 ! vestibular labyrinth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Bigotolith.jpg" xsd:anyURI
property_value: editor_note "Representation of utricle, sacule and otoliths in correspondence to other ontologies may require review. In EHDAA2, saccule and utricle are epithelia" xsd:string
property_value: UBPROP:0000003 "In fishes, as in other vertebrates, the vestibular end-organs are divided into a gravity receptor system, with three subdivisions and an angular acceleration receptor system. The gravity receptor system on each side consists of utricular, saccular, and lagenar maculae, each covered by an otolith (reference 1); (...)considerations have led to our rethinking issues related to the origin of several aspects of vertebrate hearing, and to the view that many basic auditory functions evolved very early in vertebrate history, and that the functions observed in more `advanced' vertebrates, such as birds and mammals, are frequently modifications of themes first encountered in fishes, and perhaps even more ancestral animals (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001676", ontology="VHOG", source="PMID:11581521 Moorman SJ, Development of sensory systems in zebrafish (Danio rerio). ILAR Journal (2001), DOI:10.1016/S0378-5955(00)00168-4 Fay RR, Popper AN, Evolution of hearing in vertebrates: the inner ears and processing. Hearing research (2000)", source="http://bgee.unil.ch/"}
@@ -195801,7 +195705,7 @@ intersection_of: UBERON:0002384 ! connective tissue
intersection_of: composed_primarily_of GO:0071953 ! elastic fiber
relationship: composed_primarily_of GO:0071953 ! elastic fiber
relationship: has_quality PATO:0001171 ! elastic
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png" xsd:anyURI
[Term]
id: UBERON:0002522
@@ -195825,7 +195729,7 @@ is_a: UBERON:0004797 {source="MA"} ! blood vessel layer
relationship: has_part UBERON:0002521 {source="cjm"} ! elastic tissue
relationship: has_part UBERON:0004237 {source="cjm"} ! blood vessel smooth muscle
relationship: surrounded_by UBERON:0005734 ! tunica adventitia of blood vessel
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI
[Term]
id: UBERON:0002523
@@ -195852,7 +195756,7 @@ is_a: UBERON:0004923 {source="FMA"} ! organ component layer
relationship: adjacent_to UBERON:0010161 {source="ISBN:0073040584"} ! lumen of blood vessel
relationship: has_part UBERON:0001986 ! endothelium
relationship: surrounded_by UBERON:0002522 {notes="check for exceptions, e.g. capillaries"} ! tunica media
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI
property_value: editor_note "the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure" xsd:string
property_value: editor_note "the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts" xsd:string
property_value: UBPROP:0000001 "The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia]" xsd:string {ontology="Wikipedia", source="Wikipedia:Tunica_intima"}
@@ -195940,7 +195844,7 @@ is_a: UBERON:0000062 ! organ
relationship: capable_of GO:0046903 ! secretion
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: produces UBERON:0000463 ! organism substance
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001434
property_value: UBPROP:0000007 "glandular" xsd:string
@@ -195966,7 +195870,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -196085,7 +195989,7 @@ relationship: developmentally_induced_by UBERON:0007690 {source="PMID:16313389"}
relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2499"} ! Chordata
relationship: part_of UBERON:0008814 ! pharyngeal arch system
relationship: part_of UBERON:0008816 {source="PMID:16313389"} ! embryonic head
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png" xsd:anyURI
property_value: UBPROP:0000001 "One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010359", ontology="AAO", source="NLM:branchial+arch"}
property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000155", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000013 "Numbered cranial to caudal. different in mammals. branchial arch = ZFA:0001613 pharyngeal arch 3-7. generally gill arch 1 = pharyngeal arch 3. terminology varies as to whether branchial arch follows gill or pharyngeal numbering" xsd:string
@@ -196345,7 +196249,7 @@ xref: UMLS:C0458337 {source="BIRNLEX:1128"}
xref: Wikipedia:Limbic_lobe
is_a: UBERON:0016526 {source="FMA"} ! lobe of cerebral hemisphere
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Human_brain_inferior-medial_view_description.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Human_brain_inferior-medial_view_description.JPG" xsd:anyURI
[Term]
id: UBERON:0002610
@@ -196368,7 +196272,7 @@ xref: UMLS:C0152411 {source="ncithesaurus:Cochlear_Nuclei", source="BIRNLEX:1151
xref: Wikipedia:Cochlear_nuclei
is_a: UBERON:0019263 ! gray matter of hindbrain
relationship: part_of UBERON:0001896 {inconsistent_with="MA", source="FMA"} ! medulla oblongata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray691.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002126 {source="ABA"}
property_value: RO:0002171 UBERON:0002162 {source="ABA"}
property_value: RO:0002171 UBERON:0002591 {source="ABA"}
@@ -196553,7 +196457,7 @@ xref: neuronames:351 {source="BIRNLEX:1461"}
xref: SCTID:361550004
xref: Wikipedia:Metathalamus
is_a: UBERON:0015233 ! nucleus of dorsal thalamus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1b/ThalamicNuclei.png" xsd:anyURI
property_value: RO:0002171 UBERON:0002144 {source="ABA"}
property_value: RO:0002171 UBERON:0002776 {source="ABA"}
property_value: UBPROP:0000012 "we follow FMA in making this a subtype of nucleus, but in fact it is a group containing two nuclei" xsd:string {external_ontology="FMA"}
@@ -196598,7 +196502,7 @@ is_a: UBERON:0001018 {notes="In NIFSTD this is a tract of brain but this leads t
relationship: part_of UBERON:0025525 ! motor system
relationship: part_of UBERON:0036224 ! corticobulbar and corticospinal tracts
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ac/Gray684.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ac/Gray684.png" xsd:anyURI
[Term]
id: UBERON:0002726
@@ -196675,7 +196579,7 @@ xref: Wikipedia:Basal_forebrain
is_a: UBERON:0002616 ! regional part of brain
relationship: part_of UBERON:0001890 {source="BTO"} ! forebrain
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a4/Basal_Forebrain_Monakhos_2007.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a4/Basal_Forebrain_Monakhos_2007.png" xsd:anyURI
[Term]
id: UBERON:0002749
@@ -196947,7 +196851,7 @@ xref: UMLS:C0175500 {source="BIRNLEX:2567"}
xref: Wikipedia:Ventral_cochlear_nucleus
is_a: UBERON:0001720 ! cochlear nucleus
disjoint_from: UBERON:0002829 {source="lexical"} ! dorsal cochlear nucleus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bb/Gray760.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bb/Gray760.png" xsd:anyURI
[Term]
id: UBERON:0002829
@@ -196980,7 +196884,7 @@ xref: UMLS:C0175499 {source="BIRNLEX:2569", source="ncithesaurus:Dorsal_Cochlear
xref: UMLS:C1281210 {source="BIRNLEX:2569"}
xref: Wikipedia:Dorsal_cochlear_nucleus
is_a: UBERON:0001720 ! cochlear nucleus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bb/Gray760.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bb/Gray760.png" xsd:anyURI
[Term]
id: UBERON:0002830
@@ -197105,7 +197009,7 @@ is_a: UBERON:0007635 ! nucleus of medulla oblongata
intersection_of: UBERON:0000126 ! cranial nerve nucleus
intersection_of: extends_fibers_into UBERON:0001650 ! hypoglossal nerve
relationship: extends_fibers_into UBERON:0001650 ! hypoglossal nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001719 {source="ABA"}
property_value: RO:0002171 UBERON:0002127 {source="ABA"}
property_value: RO:0002171 UBERON:0002154 {source="ABA"}
@@ -197219,8 +197123,8 @@ intersection_of: connects UBERON:0001872 ! parietal lobe
relationship: connects UBERON:0001870 ! frontal cortex
relationship: connects UBERON:0001872 ! parietal lobe
relationship: part_of UBERON:0000956 {source="NIFSTD"} ! cerebral cortex
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray726_central_sulcus.svg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/b6/Central_sulcus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray726_central_sulcus.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/b6/Central_sulcus.png" xsd:anyURI
[Term]
id: UBERON:0002921
@@ -197254,7 +197158,7 @@ xref: SCTID:369225004
xref: UMLS:C0228186 {source="BIRNLEX:4041", source="ncithesaurus:Longitudinal_Fissure"}
xref: Wikipedia:Medial_longitudinal_fissure
is_a: UBERON:0014466 {source="FMA"} ! subarachnoid fissure
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png" xsd:anyURI
[Term]
id: UBERON:0002925
@@ -197463,7 +197367,7 @@ relationship: has_part UBERON:0002148 ! locus ceruleus
relationship: has_part UBERON:0002149 ! superior salivatory nucleus
relationship: part_of UBERON:0000988 ! pons
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/9c/Brainstem_Abducens.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
property_value: UBPROP:0000009 "involved in the initiation of REM sleep [Wikipedia:Pontine_tegmentum]" xsd:string
@@ -197509,7 +197413,7 @@ intersection_of: UBERON:0005844 ! spinal cord segment
intersection_of: part_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0008231 ! dorsal thoracic segment of trunk
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray820.png" xsd:anyURI
[Term]
id: UBERON:0003041
@@ -197596,7 +197500,7 @@ intersection_of: part_of UBERON:0000924 ! ectoderm
relationship: develops_from UBERON:0006273 ! otic pit
relationship: has_potential_to_develop_into UBERON:0001846 ! internal ear
relationship: part_of UBERON:0000924 ! ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray40.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray40.png" xsd:anyURI
property_value: UBPROP:0000001 "Epithelial sac present beside the fifth rhombomere; forms the semicircular canals dorsally and the otolith organs ventrally, and houses the acoustico-vestibular sensory epithelia (maculae) of hair cells. Kimmel et al, 1995. (Also see Anatomical Atlas entry for ear by T. Whitfield.)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000051", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "One of the paired sacs of invaginated ectoderm that develop into the membranous labyrinth of the internal ear. [Biology_online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001148", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "The inner ear develops embryonically in all vertebrates as an invagination of the ectodermal otic placode to form an otic vesicle.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001148", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.413", source="http://bgee.unil.ch/"}
@@ -197858,7 +197762,7 @@ relationship: adjacent_to UBERON:0003081 ! lateral plate mesoderm
relationship: develops_from UBERON:0000926 {source="XAO"} ! mesoderm
relationship: part_of UBERON:0000926 {source="AAO"} ! mesoderm
relationship: part_of UBERON:0005256 {source="EMAPA"} ! trunk mesenchyme
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm between somite and lateral plate. Traditionally thought to give rise to the urogenital system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010575", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "(...)the mesoderm of a developing vertebrate transitionally differentiates into the following sub-types: Chordamesoderm (also known as axial mesoderm) which later on gives rise to notochord in all chordates, Paraxial mesoderm, Intermediate mesoderm, Lateral plate mesoderm (reference 1); The mesoderm is present in Bilateria, therefore they are sometimes called triploblasts. Ectoderm and endoderm are usually organized as epithelial layers, while mesoderm can be epithelial or a compact, three-dimensional tissue.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000087", ontology="VHOG", source="Wikipedia:Mesoderm, ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.43", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm')." xsd:string {external_ontology="ZFA"}
@@ -197897,7 +197801,7 @@ xref: Wikipedia:Second_pharyngeal_arch
xref: XAO:0000098
xref: ZFA:0001611
is_a: UBERON:0002539 ! pharyngeal arch
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png" xsd:anyURI
property_value: UBPROP:0000001 "The second of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010363", ontology="AAO", source="XAO:EJS"}
property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000297", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in XAO, develops from visceral pouch 2" xsd:string {external_ontology="XAO"}
@@ -197937,7 +197841,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -198093,7 +197997,7 @@ intersection_of: has_potential_to_develop_into UBERON:0000965 ! lens of camera-t
relationship: developmentally_induced_by UBERON:0004128 ! optic vesicle
relationship: has_potential_to_develop_into UBERON:0000965 ! lens of camera-type eye
relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
property_value: UBPROP:0000001 "Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000122", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006)" xsd:string {source="NCBIBook:NBK53175"}
@@ -198130,7 +198034,7 @@ is_a: UBERON:0009201 {source="GO"} ! nephric duct
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003060 ! pronephric duct
relationship: develops_from UBERON:0005792 {source="EHDAA2"} ! nephric ridge
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
property_value: editor_note "Consider adding subclasses for male and female specific variants" xsd:string
property_value: editor_note "TODO - mesonephric portion of the nephric duct" xsd:string
property_value: UBPROP:0000001 "Anatomical structure consisting of either of a pair of longitudinal ducts which carry urine and in males, sperm, to the cloaca.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000637", ontology="AAO", source="AAO:BJB"}
@@ -198172,7 +198076,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -198221,7 +198125,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -198298,7 +198202,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -198339,7 +198243,7 @@ xref: ZFA:0001056
is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure
relationship: contributes_to_morphology_of UBERON:0001630 ! muscle organ
relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: editor_note "The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere." xsd:string
property_value: UBPROP:0000001 "Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001056", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001244", ontology="VHOG", source="DOI:10.1038/sj.embor.embor920 Hollway GE, Currie PD, Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Rep.(2003)", source="http://bgee.unil.ch/"}
@@ -198444,7 +198348,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -198502,7 +198406,7 @@ is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0034705 {source="EHDAA2"} ! developing neuroepithelium
relationship: develops_from UBERON:0003072 ! optic cup
relationship: part_of UBERON:0001894 ! diencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
property_value: UBPROP:0000001 "The evagination from the neural tube of the developing embryo which develops the optic cup at its extremity; the stalk persists as the optic nerve. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000223", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/optic+stalk"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000223", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -198664,7 +198568,7 @@ relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: has_developmental_contribution_from UBERON:0000926 {gci_relation="part_of", gci_filler="NCBITaxon:7711"} ! mesoderm
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -199115,7 +199019,7 @@ relationship: has_part UBERON:0003265 ! chorionic mesenchyme
relationship: has_part UBERON:0003374 ! chorionic ectoderm
relationship: only_in_taxon NCBITaxon:32524 {source="Hymans"} ! Amniota
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/51/Gray24.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/51/Gray24.png" xsd:anyURI
property_value: UBPROP:0000001 "The outer membrane enclosing the embryo in reptiles, birds, and mammals. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000200", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/chorion"}
property_value: UBPROP:0000001 "The outer membrane of the two membranes enclosing the embryo in reptiles, birds, and mammals. In placental mammals it contributes to the development of the placenta[BTO:0000252]." xsd:string {source="BTO:0000252"}
property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000200", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"}
@@ -199164,8 +199068,8 @@ relationship: located_in UBERON:0002224 ! thoracic cavity
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0007196 ! tracheobronchial tree
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c3/Illu_conducting_passages.jpg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-trachea.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-trachea.glb" xsd:string
@@ -199499,6 +199403,21 @@ relationship: part_of UBERON:5102544 ! individual digit of digitopodial skeleton
property_value: UBPROP:0000007 "phalangeal" xsd:string
property_value: UBPROP:0000008 "In primates such as humans and monkeys, the thumb and big toe have two phalanges, while the other fingers and toes consist of three" xsd:string {source="WP"}
+[Term]
+id: UBERON:0003224
+name: chorion syncytiotrophoblast
+namespace: uberon
+def: "An extraembryonic structure that develops_from a syncytiotrophoblast and is part of a chorion." [OBOL:automatic]
+xref: EHDAA2:0001973
+xref: EHDAA:156
+is_a: UBERON:0000478 ! extraembryonic structure
+intersection_of: UBERON:0000478 ! extraembryonic structure
+intersection_of: develops_from UBERON:0000371 ! syncytiotrophoblast
+intersection_of: part_of UBERON:0003124 ! chorion membrane
+relationship: develops_from UBERON:0000371 {notes="polar trophectoderm syncytiotrophoblast", source="EHDAA2"} ! syncytiotrophoblast
+relationship: part_of UBERON:0003124 {source="EHDAA2"} ! chorion membrane
+property_value: editor_note "TODO - check" xsd:string
+
[Term]
id: UBERON:0003229
name: epithelium of elbow
@@ -199854,7 +199773,7 @@ is_a: UBERON:0010912 ! subdivision of skeleton
relationship: contributes_to_morphology_of UBERON:0005944 ! axial skeleton plus cranial skeleton
relationship: part_of UBERON:0014477 ! thoracic skeleton
relationship: part_of UBERON:0014478 ! rib skeletal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/88/Gray112.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/88/Gray112.png" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical cluster that consists of more than one rib in an individual.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002100", ontology="TAO", source="TAO:wd"}
[Term]
@@ -199873,7 +199792,7 @@ is_a: UBERON:0018664 ! neck of bone element
intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0002228 ! rib
relationship: part_of UBERON:0010388 {source="PMID:15906248"} ! proximal segment of rib
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray122.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray122.png" xsd:anyURI
[Term]
id: UBERON:0003254
@@ -202684,7 +202603,7 @@ is_a: UBERON:0003496 ! head blood vessel
intersection_of: UBERON:0001637 ! artery
intersection_of: supplies UBERON:0002037 ! cerebellum
relationship: supplies UBERON:0002037 ! cerebellum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e1/CerebellumArteries.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e1/CerebellumArteries.jpg" xsd:anyURI
[Term]
id: UBERON:0003473
@@ -202788,7 +202707,7 @@ intersection_of: UBERON:0001638 ! vein
intersection_of: drains UBERON:0001835 ! lower lip
relationship: drains UBERON:0001835 ! lower lip
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png" xsd:anyURI
[Term]
id: UBERON:0003479
@@ -203605,8 +203524,8 @@ name: hindlimb skin
namespace: uberon
def: "A zone of skin that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic]
synonym: "hind limb skin" EXACT [OBOL:automatic]
-synonym: "lower limb skin" EXACT [https://orcid.org/0000-0002-0819-0473]
synonym: "lower limb skin" EXACT [FMA:23102]
+synonym: "lower limb skin" EXACT [https://orcid.org/0000-0002-0819-0473]
synonym: "skin of hind limb" EXACT [OBOL:automatic]
synonym: "skin of hindlimb" EXACT [OBOL:automatic]
synonym: "skin of lower extremity" EXACT [OBOL:automatic]
@@ -205016,7 +204935,7 @@ intersection_of: part_of UBERON:0003126 ! trachea
relationship: develops_from UBERON:0007267 ! trachea pre-cartilage rings
relationship: part_of UBERON:0003126 ! trachea
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/56/Gray952.png" xsd:anyURI
property_value: editor_note "check whether to classify as part of splanchoncranium" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -205664,7 +205583,7 @@ intersection_of: luminal_space_of UBERON:0000916 ! abdomen
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0035819 ! abdominopelvic cavity
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
property_value: UBPROP:0000012 "in FMA this contains the pelvic cavity, but this is inconsistent with the concept of abdominopelvic cavity" xsd:string {external_ontology="FMA"}
[Term]
@@ -205718,7 +205637,7 @@ intersection_of: UBERON:0013685 ! foramen of skull
intersection_of: conduit_for UBERON:0001896 ! medulla oblongata
relationship: conduit_for UBERON:0001896 ! medulla oblongata
relationship: located_in UBERON:0001676 ! occipital bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/39/Gray130.png" xsd:anyURI
property_value: UBPROP:0000001 "Foramen in the occipital region of neurocranium to allow passage of spinal cord.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002045", ontology="TAO", source="TAO:wd"}
[Term]
@@ -205788,7 +205707,7 @@ intersection_of: connects UBERON:0001105 ! clavicle bone
intersection_of: connects UBERON:0002497 ! acromion
relationship: connects UBERON:0001105 ! clavicle bone
relationship: connects UBERON:0002497 ! acromion
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Gray326.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3b/Gray326.png" xsd:anyURI
property_value: UBPROP:0000001 "The gliding joint formed by the outer extremity of the clavicle and the inner margin of the acromion process of the scapula." xsd:string {source="MESH:A02.835.583.032"}
[Term]
@@ -205818,7 +205737,7 @@ intersection_of: connects UBERON:0001093 ! vertebral bone 2
relationship: connects UBERON:0001092 ! vertebral bone 1
relationship: connects UBERON:0001093 ! vertebral bone 2
relationship: part_of UBERON:0011138 ! postcranial axial skeletal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI
[Term]
id: UBERON:0003695
@@ -205852,7 +205771,7 @@ intersection_of: connects UBERON:0002374 ! metacarpal bone
relationship: connects UBERON:0002234 ! proximal phalanx of manus
relationship: connects UBERON:0002374 ! metacarpal bone
relationship: part_of UBERON:0002389 ! manual digit
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray337.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray337.png" xsd:anyURI
property_value: editor_note "we follow FMA in making these joints part of digits. We include carpometacarpophalangeal joint as a synonym - these joints connect to the carpometacarpus - this is not necessarily inconsistent with the relationship for this class to metacarpal bone, as the carpometacarpus could be considered to have a metacarpal as part" xsd:string
property_value: UBPROP:0000202 FMA:71364
@@ -205884,7 +205803,7 @@ intersection_of: connects UBERON:0003867 ! distal phalanx of pes
relationship: connects UBERON:0001448 ! metatarsal bone
relationship: connects UBERON:0003867 ! distal phalanx of pes
relationship: part_of UBERON:0001466 ! pedal digit
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray268.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray268.png" xsd:anyURI
property_value: editor_note "we follow FMA in making these joints part of digits" xsd:string
[Term]
@@ -205912,7 +205831,7 @@ is_a: UBERON:0000060 ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
[Term]
id: UBERON:0003703
@@ -205983,7 +205902,7 @@ xref: Wikipedia:Circle_of_Willis
is_a: UBERON:0004573 ! systemic artery
relationship: overlaps UBERON:0007142 {source="FMA-modified"} ! left internal carotid artery
relationship: overlaps UBERON:0007143 {source="FMA-modified"} ! right internal carotid artery
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2e/Circle_of_Willis_en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In zebrafish, the circle of vessels comprised of the basal communicating artery (BCA) and posterior communicating segments (PCS) superficially resemble but are not homologous to the human circle of Willis" xsd:string {source="http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html"}
[Term]
@@ -206014,7 +205933,7 @@ is_a: UBERON:0001638 ! vein
relationship: connected_to UBERON:0001585 ! anterior vena cava
relationship: part_of UBERON:0007204 ! brachiocephalic vasculature
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/9e/Gray1174.png" xsd:anyURI
[Term]
id: UBERON:0003712
@@ -206063,8 +205982,8 @@ xref: Wikipedia:Splenic_vein
is_a: UBERON:0001638 ! vein
relationship: connected_to UBERON:0001639 ! hepatic portal vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5b/Gray1189.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e4/Bilebladder.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -206222,7 +206141,7 @@ xref: SCTID:279568001
xref: UMLS:C1285089 {source="ncithesaurus:Intercostal_Nerve"}
xref: Wikipedia:Intercostal_nerves
is_a: UBERON:0001780 ! spinal nerve
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Gray819.png" xsd:anyURI
[Term]
id: UBERON:0003728
@@ -206246,7 +206165,7 @@ xref: Wikipedia:Mediastinum
is_a: UBERON:0002553 ! anatomical cavity
relationship: part_of UBERON:0002224 ! thoracic cavity
relationship: surrounded_by UBERON:0035431 {source="FMA"} ! mediastinal pleura
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Mediastinum.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Mediastinum.png" xsd:anyURI
property_value: UBPROP:0000007 "mediastinal" xsd:string
[Term]
@@ -206886,7 +206805,7 @@ is_a: UBERON:0001638 ! vein
intersection_of: UBERON:0001638 ! vein
intersection_of: attaches_to UBERON:0000991 ! gonad
relationship: attaches_to UBERON:0000991 ! gonad
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Gray1120.png" xsd:anyURI
[Term]
id: UBERON:0003849
@@ -207126,7 +207045,7 @@ xref: ZFA:0001066
is_a: UBERON:0002513 ! endochondral bone
is_a: UBERON:0010358 ! arch of centrum of vertebra
relationship: develops_from UBERON:0006063 ! cartilaginous neural arch
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png" xsd:anyURI
property_value: UBPROP:0000001 "A neural arch encloses the neural canal and typically meets its partner to form a neural spine. The neural arch can be a replacement ossification of the basidorsal cartilage or can form directly in membrane bone.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001066", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Bony arch perched on the vertebral centrum; successive arches enclose the neural canal that surrounds and protects the spinal cord dorsally.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000725", ontology="AAO", source="AAO:Pugener_2002"}
property_value: UBPROP:0000001 "the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" xsd:string {source="MP:0004599:csmith"}
@@ -207376,7 +207295,7 @@ relationship: in_lateral_side_of UBERON:0003975 {source="FMA-abduced-lr"} ! inte
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of UBERON:0002355 ! pelvic region of trunk
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "Homologous to appendix testis" xsd:string {source="Wikipedia:Talk:Fallopian_tube#Homology"}
[Term]
@@ -207409,7 +207328,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0003064 {source="Wikipedia"} ! intermediate mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
property_value: UBPROP:0000001 "Either of the paired embryonic ducts developing into the uterine tubes, uterus, and vagina in the female and becoming largely obliterated in the male. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001199", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/paramesonephric+duct"}
property_value: UBPROP:0000001 "Transient developmental organ which gives rise to oviducts in female (documented to persist in some male frogs).[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010141", ontology="AAO", source="AAO:RED"}
property_value: UBPROP:0000003 "In females, the archinephric (mesonephric) ducts tend to function only within the urinary systems. The muellerian duct arises embryologically next to the archinephric (wolffian) duct. In males, the muellerian duct regresses if it appears at all, but in females, the muellerian ducts become the oviducts of the reproductive system.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001199", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.559", source="http://bgee.unil.ch/"}
@@ -207722,7 +207641,7 @@ intersection_of: has_potential_to_develop_into UBERON:0001264 ! pancreas
relationship: develops_from UBERON:0000925 {source="Wikipedia"} ! endoderm
relationship: has_potential_to_develop_into UBERON:0001264 ! pancreas
relationship: part_of UBERON:0007026 ! presumptive gut
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
property_value: UBPROP:0000012 "in EHDAA2 this has dorsal and ventral primordia as parts. the buds are part of the primordium, with the ducts developing from the buds; only parenchyma and ducts have contribution from buds" xsd:string {external_ontology="EHDAA2"}
property_value: UBPROP:0000013 "revisit after standardizing terms 'primordium', 'anlagen', 'bud'" xsd:string
@@ -207752,8 +207671,8 @@ relationship: develops_from UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0002114 {exception="zebrafish", source="Wikipedia:Pancreatic_bud"} ! duodenum
relationship: develops_from UBERON:0009497 {source="EHDAA2-inferred"} ! epithelium of foregut-midgut junction
relationship: part_of UBERON:0003921 {source="EHDAA2"} ! pancreas primordium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/49/Suckale08FBS_fig1_pancreas_development.jpeg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
[Term]
id: UBERON:0003923
@@ -207784,7 +207703,7 @@ relationship: developmentally_induced_by UBERON:0002328 {gci_relation="part_of",
relationship: developmentally_induced_by UBERON:0005805 {gci_relation="part_of", gci_filler="NCBITaxon:10088", source="PMID:16417468"} ! dorsal aorta
relationship: develops_from UBERON:0001045 {source="XAO"} ! midgut
relationship: part_of UBERON:0010375 {source="EHDAA2"} ! pancreas dorsal primordium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
property_value: UBPROP:0000001 "The pancreatic bud that gives rise to the accessory pancreatic duct.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011031", ontology="AAO", source="XAO:curator"}
property_value: UBPROP:0000003 "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001428", ontology="VHOG", source="DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000)", source="http://bgee.unil.ch/"}
@@ -207814,7 +207733,7 @@ xref: ZFA:0001369
is_a: UBERON:0003922 ! pancreatic epithelial bud
relationship: develops_from UBERON:0008835 {source="PMID:16417468", source="WP"} ! hepatic diverticulum
relationship: part_of UBERON:0010376 {source="EHDAA2"} ! pancreas ventral primordium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/db/Gray982.png" xsd:anyURI
property_value: UBPROP:0000003 "In chick, Xenopus laevis, and the teleost fish Medaka, the pancreas develops from three buds that emerge from the gut tube, two from its ventral aspect, and one from its dorsal aspect. In mouse, although there are initially three buds that arise from the gut tube at the point of contact between the endoderm and the vasculature, the pancreas develops from only two of these buds, one dorsal and one ventral. (...) In this study, we use a transgenic zebrafish line (...). We provide evidence for the existence of two distinct pancreatic anlagen - a ventral anterior bud and a dorsal posterior bud - that join to form the definitive pancreas (reference 1); The pancreas develops from the fusion of distinct endoderm-derived dorsal and ventral diverticula. In humans, by day 35 of development, the ventral pancreatic bud begins to migrate backwards and comes into contact and eventually fuses with the dorsal pancreatic bud during the sixth week of development (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001429", ontology="VHOG", source="DOI:10.1016/S0012-1606(03)00308-7 Field HA, Dong PD, Beis D, Stainier DY, Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology (2003), DOI:10.2337/diabetes.49.2.225 Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P, Early pattern of differentiation in the human pancreas. Diabetes (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "the ventral pancreas and liver are derived from a common precursor cell population[PMID:16417468]. TODO - add this relationship." xsd:string
property_value: UBPROP:0000011 "The ventral pancreatic bud becomes the head and uncinate process, and comes from the hepatic diverticulum[WP]" xsd:string
@@ -208056,7 +207975,7 @@ relationship: channels_from UBERON:0001343 ! seminiferous tubule of testis
relationship: channels_into UBERON:0006946 ! efferent duct
relationship: develops_from UBERON:0005297 {source="Wikipedia"} ! testis sex cord
relationship: part_of UBERON:0005051 ! mediastinum testis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI
property_value: editor_note "add more specific classification e.g. anastomosing network - consider FMA:3726" xsd:string
[Term]
@@ -208177,7 +208096,7 @@ xref: AAO:0010250
xref: Wikipedia:Conus_arteriosus
is_a: UBERON:0004151 ! cardiac chamber
relationship: part_of UBERON:0002080 ! heart right ventricle
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/46/Gray492.png" xsd:anyURI
property_value: UBPROP:0000001 "Receives blood from the left atrium and becomes the median truncus arteriosus.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010250", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000008 "Kardong says absent in adult tetrapods, check AAO" xsd:string
property_value: UBPROP:0000013 "we use the term CA for the anterior chamber if it is composed of cardiac muscle, contractile, and contains conal valves internally" xsd:string {source="ISBN:0073040584"}
@@ -208203,7 +208122,7 @@ relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0003889 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! fallopian tube
relationship: present_in_taxon NCBITaxon:8782 ! Aves
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/66/Illu_cervix.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]." xsd:string {source="Wikipedia:Infundibulum_of_uterine_tube"}
property_value: UBPROP:0000008 "In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct." xsd:string {xref="https://orcid.org/0000-0002-2825-0621"}
@@ -208303,7 +208222,7 @@ xref: Wikipedia:Dermatome_(embryology)
xref: XAO:0000220
is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure
relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png" xsd:anyURI
property_value: UBPROP:0000013 "Not to be confused with 'dermatome segment of skin'." xsd:string
[Term]
@@ -208505,7 +208424,7 @@ xref: SCTID:279759001
xref: Wikipedia:Osseous_ampullae
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0001856 {source="MA"} ! semicircular duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Vestibular_system%27s_semicircular_canal-_a_cross-section.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/65/Vestibular_system%27s_semicircular_canal-_a_cross-section.jpg" xsd:anyURI
property_value: editor_note "TODO check duct vs canal. Also check FMA - has many subtypes of semicircular canal such as 'ampulla of anterior semicircular canal'" xsd:string
[Term]
@@ -208722,7 +208641,7 @@ xref: VHOG:0001319
xref: Wikipedia:Frontonasal_prominence
is_a: UBERON:0009292 ! embryonic nasal process
relationship: intersects_midsagittal_plane_of UBERON:0000033 ! head
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/98/Gray44.png" xsd:anyURI
[Term]
id: UBERON:0004067
@@ -208744,7 +208663,7 @@ is_a: UBERON:0009292 ! embryonic nasal process
disjoint_from: UBERON:0004068 {source="lexical"} ! medial nasal prominence
relationship: develops_from UBERON:0004066 {source="Wikipedia"} ! frontonasal prominence
relationship: part_of UBERON:0004066 {source="EHDAA2"} ! frontonasal prominence
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
[Term]
id: UBERON:0004068
@@ -208768,7 +208687,7 @@ is_a: UBERON:0009292 ! embryonic nasal process
relationship: develops_from UBERON:0004066 {source="Wikipedia"} ! frontonasal prominence
relationship: in_lateral_side_of UBERON:0008816 ! embryonic head
relationship: part_of UBERON:0004066 {source="EHDAA2"} ! frontonasal prominence
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/85/Gray45.png" xsd:anyURI
property_value: UBPROP:0000011 "Fusion of right and left medial nasal processes forms a primary palate rostrally and the nasal septum caudally. The incisive bone, including upper incisor teeth and the rostral up- per lip, are derived from the primary palate. The nasal septum consists of bone, cartilage, and a patch of soft tissue membrane that separates right & left halves of the nasal cavity." xsd:string
[Term]
@@ -208822,8 +208741,8 @@ xref: UMLS:C0042460 {source="ncithesaurus:Vena_Cava"}
xref: Wikipedia:Venae_cavae
is_a: UBERON:0003479 ! thoracic cavity vein
is_a: UBERON:0013768 ! great vessel of heart
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/35/Relations_of_the_aorta,_trachea,_esophagus_and_other_heart_structures.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7c/Heart_numlabels.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -208895,7 +208814,7 @@ xref: Wikipedia:Collecting_duct_system
is_a: UBERON:0000467 ! anatomical system
relationship: part_of UBERON:0002113 ! kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0004103
@@ -209024,7 +208943,7 @@ relationship: luminal_space_of UBERON:0001756 ! middle ear
relationship: part_of UBERON:0001756 ! middle ear
relationship: surrounded_by UBERON:0010063 ! tympanic cavity epithelium
relationship: surrounds UBERON:0001686 ! auditory ossicle bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray923.png" xsd:anyURI
[Term]
id: UBERON:0004115
@@ -209301,7 +209220,7 @@ relationship: developmentally_induced_by UBERON:0004880 ! chordamesoderm
relationship: develops_from UBERON:0002346 {source="GO-def"} ! neurectoderm
relationship: develops_from UBERON:0003071 {source="ZFA"} ! eye primordium
relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
[Term]
@@ -209911,7 +209830,7 @@ relationship: contributes_to_morphology_of UBERON:0005164 ! ascending limb of lo
relationship: part_of UBERON:0003455 ! inner renal medulla loop of Henle
relationship: part_of UBERON:0005164 ! ascending limb of loop of Henle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
property_value: editor_note "check relationship to distal tubule" xsd:string
[Term]
@@ -209994,7 +209913,7 @@ is_a: UBERON:0000064 ! organ part
relationship: contributes_to_morphology_of UBERON:0000362 ! renal medulla
relationship: part_of UBERON:0000362 ! renal medulla
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb" xsd:string
@@ -211652,7 +211571,7 @@ is_a: UBERON:0003837 ! thoracic segment connective tissue
relationship: adjacent_to UBERON:0002081 ! cardiac atrium
relationship: adjacent_to UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0000948 ! heart
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png" xsd:anyURI
property_value: UBPROP:0000009 "It is not a true skeleton, but it does provide structure and support for the heart, as well as isolating the atria from the ventricles. This allows the AV node and AV bundle to delay the wave of depolarisation such that the atria can contract and assist in ventricular filling before the ventricles themselves depolarise and contract (the AV bundle is the only part of the conduction system that passes from the atria to the ventricles in a normal heart). It also allows the valves (bicuspid, tricuspid, semilunar) to keep open by giving them structural support[WP]" xsd:string
[Term]
@@ -211759,7 +211678,7 @@ intersection_of: UBERON:0003221 ! phalanx
intersection_of: proximally_connected_to UBERON:0004301 ! middle phalanx
relationship: part_of UBERON:0009551 ! distal segment of digit
relationship: proximally_connected_to UBERON:0004301 ! middle phalanx
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Scheme_human_hand_bones-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ab/Scheme_human_hand_bones-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In human anatomy, the distal phalanges of the four fingers and toes articulate proximally with the intermediate phalanges at the distal interphalangeal joints (DIP); in the thumb and big toe, with only two phalanges, the distal phalanges articulate proximally with the proximal phalanges. The distal phalanges carry and shape nails and claws and are therefore occasionally referred to as the ungual phalanges. The distal phalanges are cone-shaped in most mammals, including most primates, but relatively wide and flat in humans." xsd:string
[Term]
@@ -211831,7 +211750,7 @@ relationship: has_developmental_contribution_from UBERON:0000925 {notes="hindgut
relationship: has_developmental_contribution_from UBERON:0004872 {source="ISBN:0073040584"} ! splanchnic layer of lateral plate mesoderm
relationship: only_in_taxon NCBITaxon:32524 {source="Hymans"} ! Amniota
relationship: overlaps UBERON:0001008 {source="EHDAA2-modified"} ! renal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray25.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a5/Gray25.png" xsd:anyURI
property_value: UBPROP:0000001 "A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000738", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/allantois"}
property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000738", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "allantoic" xsd:string
@@ -211861,7 +211780,7 @@ is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0008780 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="ISBN:9780878932504"} ! inner cell mass derived epiblast
relationship: has_potential_to_develop_into UBERON:0000925 ! endoderm
relationship: has_potential_to_develop_into UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Gray13.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Gray13.png" xsd:anyURI
property_value: RO:0002174 NCBITaxon:32443
property_value: UBPROP:0000003 "(...) the blastopore equivalent of chordates (germ ring in fish, marginal zone/blastopore lip in frog and node/primitive streak in chick and mouse) (...) (reference 1); Indeed, the primitive streak has been considered the homologue of the blastopore since the 1870s (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001202", ontology="VHOG", source="PMID:9609826 Wu LH, Lengyel JA, Role of caudal in hindgut specification and gastrulation suggests homology between Drosophila amnioproctodeal invagination and vertebrate blastopore. Development (1998), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.139", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "VHOG includes a very broad grouping here based on http://www.ncbi.nlm.nih.gov/pubmed/9609826" xsd:string {external_ontology="VHOG"}
@@ -211953,7 +211872,7 @@ relationship: developmentally_induced_by UBERON:0003104 ! mesenchyme
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0004357 ! paired limb/fin bud
relationship: produces PR:000007499 ! fibroblast growth factor 8
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg" xsd:anyURI
property_value: IAO:0000232 "note that media, dorsal fins etc have AERs." xsd:string
property_value: UBPROP:0000001 "Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010760", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Proliferative region that is part of the developing fin fold or fin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002146", ontology="TAO", source="ZFIN:curator"}
@@ -212013,7 +211932,7 @@ xref: Wikipedia:First_pharyngeal_arch
xref: XAO:0000097
xref: ZFA:0001612
is_a: UBERON:0002539 ! pharyngeal arch
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
property_value: UBPROP:0000001 "the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery" xsd:string {source="MP:0006337,MGI:smb"}
property_value: UBPROP:0000001 "The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010364", ontology="AAO", source="XAO:EJS"}
property_value: UBPROP:0000003 "A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000296", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005)", source="http://bgee.unil.ch/"}
@@ -212063,7 +211982,7 @@ relationship: contributes_to_morphology_of UBERON:0002539 ! pharyngeal arch
relationship: has_potential_to_develop_into UBERON:0001637 ! artery
relationship: part_of UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0007303 {source="ZFA"} ! pharyngeal vasculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/84/Gray473.png" xsd:anyURI
property_value: editor_note "add specific artery derivatives" xsd:string
property_value: IAO:0000232 "Do not confuse with arch of aorta." xsd:string
property_value: UBPROP:0000001 "Paired vessels arching from the ventral to the dorsal aorta through the pharyngeal arches. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000122", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aortic+arches"}
@@ -212406,7 +212325,7 @@ is_a: UBERON:0004380 ! proximal epiphysis
is_a: UBERON:0004382 ! epiphysis of humerus
intersection_of: UBERON:0004380 ! proximal epiphysis
intersection_of: part_of UBERON:0000976 ! humerus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray207.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray207.png" xsd:anyURI
[Term]
id: UBERON:0004412
@@ -212583,8 +212502,8 @@ relationship: distally_connected_to UBERON:0004453 ! metacarpus region
relationship: has_skeleton UBERON:0009880 ! carpal skeleton
relationship: part_of UBERON:0002398 ! manus
relationship: proximally_connected_to UBERON:0002386 ! forelimb zeugopod
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/cc/Hand_parts.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4a/Human_wrist.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/cc/Hand_parts.jpg" xsd:anyURI
[Term]
id: UBERON:0004453
@@ -212610,7 +212529,7 @@ intersection_of: UBERON:0009877 ! metapodium region
intersection_of: part_of UBERON:0002398 ! manus
relationship: has_skeleton UBERON:0010544 ! metacarpus skeleton
relationship: part_of UBERON:0012141 {source="PHENOSCAPE:ni"} ! manual digitopodium region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI
property_value: editor_note "Note that along with FMA we treat this as a limb segment rather than a purely skeletal element" xsd:string
property_value: UBPROP:0000007 "metacarpal" xsd:string
property_value: UBPROP:0000012 "Note that mammalian and non-mammalian AOs differ in whether they consider this a part of the skeleton" xsd:string
@@ -212649,7 +212568,7 @@ relationship: distally_connected_to UBERON:0000983 ! metatarsus region
relationship: has_skeleton UBERON:0009879 ! tarsal skeleton
relationship: part_of UBERON:0002387 ! pes
relationship: proximally_connected_to UBERON:0003823 ! hindlimb zeugopod
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/bf/Ankle_en.svg" xsd:anyURI
property_value: IAO:0000232 "this term refers to the limb segment. See also: tarsal bones and tarsal skeleton" xsd:string
property_value: UBPROP:0000012 "MA has both tarsus (part of foot, has tarsal bone) and ankle (part of hindlimb, has joint, nerve, skin)." xsd:string {external_ontology="MA"}
@@ -213885,7 +213804,7 @@ relationship: contributes_to_morphology_of UBERON:0001229 ! renal corpuscle
relationship: part_of UBERON:0001229 ! renal corpuscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0001285 ! nephron
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0004640
@@ -213916,7 +213835,7 @@ relationship: connected_to UBERON:0004212 ! glomerular capillary
relationship: contributes_to_morphology_of UBERON:0001229 ! renal corpuscle
relationship: part_of UBERON:0001229 ! renal corpuscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0004641
@@ -214233,7 +214152,7 @@ relationship: composed_primarily_of CL:0000065 ! ependymal cell
relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system
relationship: develops_from UBERON:0004060 ! neural tube ventricular layer
relationship: part_of UBERON:0005358 ! ventricle of nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray667.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray667.png" xsd:anyURI
property_value: RO:0002171 GO:0005604
property_value: UBPROP:0000007 "ependymal" xsd:string
property_value: UBPROP:0000010 "unlike other epithelia, there is no basement membrane under the ependymal epithelium[ISBN:0387949542]" xsd:string
@@ -214403,7 +214322,7 @@ xref: ZFA:0001429
is_a: UBERON:0002616 ! regional part of brain
relationship: capable_of GO:0001820 {source="Wikipedia"} ! serotonin secretion
relationship: part_of UBERON:0002275 {source="GO", source="Wikipedia"} ! reticular formation
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png" xsd:anyURI
[Term]
id: UBERON:0004688
@@ -214422,7 +214341,7 @@ xref: Wikipedia:Costocervical_trunk
is_a: UBERON:0001637 ! artery
relationship: connected_to UBERON:0001533 ! subclavian artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png" xsd:anyURI
[Term]
id: UBERON:0004692
@@ -214640,7 +214559,7 @@ xref: UMLS:C1284055 {source="ncithesaurus:Bulbus_Cordis"}
xref: Wikipedia:Bulbus_cordis
is_a: UBERON:0002050 ! embryonic structure
relationship: part_of UBERON:0000948 ! heart
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c9/Gray466.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c9/Gray466.png" xsd:anyURI
property_value: editor_note "TODO - check relationship to bulbus arteriosus" xsd:string
property_value: UBPROP:0000001 "A pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. The bulbus arteriosus has three distinct layers. Hu et al. 2000.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000173", ontology="TAO", source="ZFIN:curator"}
@@ -214761,7 +214680,7 @@ xref: Wikipedia:Jugular_vein
is_a: UBERON:0001638 ! vein
relationship: drains UBERON:0000033 ! head
relationship: part_of UBERON:0000974 {gci_filler="NCBITaxon:40674", gci_relation="in_taxon"} ! neck
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png" xsd:anyURI
[Term]
id: UBERON:0004715
@@ -214783,7 +214702,7 @@ intersection_of: UBERON:0006444 ! annulus fibrosus
intersection_of: part_of UBERON:0001066 ! intervertebral disk
disjoint_from: UBERON:0006008 ! fibrous ring of heart
relationship: part_of UBERON:0001066 ! intervertebral disk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d9/Cervical_vertebra_english.png" xsd:anyURI
[Term]
id: UBERON:0004716
@@ -214829,7 +214748,7 @@ is_a: UBERON:0013126 ! vein of abdomen
is_a: UBERON:0014401 ! renal venous blood vessel
relationship: connected_to UBERON:0009887 ! interlobar vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
property_value: UBPROP:0000202 FMA:71632
[Term]
@@ -214852,7 +214771,7 @@ xref: Wikipedia:Crista_ampullaris
is_a: UBERON:0000020 ! sense organ
relationship: contributes_to_morphology_of UBERON:0004043 ! semicircular canal ampulla
relationship: part_of UBERON:0004043 {source="MA"} ! semicircular canal ampulla
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Semicircular_canal_-_ampulla.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Semicircular_canal_-_ampulla.png" xsd:anyURI
[Term]
id: UBERON:0004723
@@ -214879,7 +214798,7 @@ is_a: UBERON:0003644 ! kidney arterial blood vessel
disjoint_from: UBERON:0009885 {source="Wikipedia:Renal_circulation"} ! interlobar artery
relationship: connected_to UBERON:0001552 ! kidney arcuate artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0004725
@@ -214920,7 +214839,7 @@ relationship: contributes_to_morphology_of UBERON:0002894 ! olfactory cortex
relationship: only_in_taxon NCBITaxon:32523 {source="Wikipedia"} ! Tetrapoda
relationship: part_of UBERON:0002894 ! olfactory cortex
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
property_value: UBPROP:0000008 "Piriform cortical regions are present in the brains of amphibians, reptiles and mammals. The piriform cortex is among three areas that emerge in the telencephalon of amphibians, situated caudally to a dorsal area, which is caudal to a hippocampal area. Farther along the phylogenic timeline, the telencephalic bulb of reptiles as viewed in a cross section of the transverse plane extends with the archipallial hippocampus folding toward the midline and down as the dorsal area begins to form a recognizable cortex. As mammalian cerebrums developed, volume of the dorsal cortex increased in slightly greater proportion, as compared proportionally with increased overall brain volume, until it enveloped the hippocampal regions. Recognized as neopallium or neocortex, enlarged dorsal areas envelop the paleopallial piriform cortex in humans and Old World monkeys. Among taxonomic groupings of mammals, the piriform cortex and the olfactory bulb become proportionally smaller in the brains of phylogenically younger species. The piriform cortex occupies a greater proportion of the overall brain and of the telencephalic brains of insectivores than in primates. The piriform cortex continues to occupy a consistent albeit small and declining proportion of the increasingly large telencephalon in the most recent primate species while the volume of the olfactory bulb becomes less in proportion" xsd:string {source="WP"}
@@ -214952,7 +214871,7 @@ xref: Wikipedia:Vasa_recta
is_a: UBERON:0001140 ! renal vein
relationship: connected_to UBERON:0004640 ! renal efferent arteriole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/21/Kidney_nephron.png" xsd:anyURI
property_value: editor_note "TODO - is this a vein or set of veins? in MA it is a venous blood vessel" xsd:string
[Term]
@@ -215400,7 +215319,7 @@ xref: MESH:D018483
xref: SCTID:361729006
xref: Wikipedia:Diaphysis
is_a: UBERON:0005055 ! zone of long bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Subdivision of long bone which forms the part of the bone between the two epiphyses; together with other the subdivisions of long bone, it constitutes the long bone. Examples: diaphysis of humerus, diaphysis of femur[FMA]." xsd:string {source="FMA:24013"}
property_value: UBPROP:0000001 "The main or mid section (shaft) of a long bone. It is made up of cortical bone and usually contains bone marrow and adipose tissue (fat)[WP][FMA:24013, Wikipedia:Diaphysis]." xsd:string {source="FMA:24013, Wikipedia:Diaphysis"}
@@ -215457,7 +215376,7 @@ intersection_of: connects UBERON:0001707 ! nasal cavity
intersection_of: connects UBERON:0001728 ! nasopharynx
relationship: connects UBERON:0001728 ! nasopharynx
relationship: part_of UBERON:0003128 ! cranium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/87/Gray855.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/87/Gray855.png" xsd:anyURI
property_value: UBPROP:0000001 "One of the paired openings from the nasal cavities into the pharynx. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-6, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000545", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Opening between the nasal cavity and the nasopharynx.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000093", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "The choana, a unique 'internal nostril' opening from the nasal sac into the roof of the mouth, is a key part of the tetrapod (land vertebrate) respiratory system. It was the first component of the tetrapod body plan to evolve, well before the origin of limbs, and is therefore crucial to our understanding of the beginning of the fish-tetrapod transition. (...) Here we present new material of Kenichthys, a 395-million-year-old fossil fish from China, that provides direct evidence for the origin of the choana and establishes its homology: it is indeed a displaced posterior external nostril that, during a brief transitional stage illustrated by Kenichthys, separated the maxilla from the premaxilla.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000545", ontology="VHOG", source="DOI:10.1038/nature02843 Zhu M, Ahlberg PE, The origin of the internal nostril in tetrapodes. Nature (2004)", source="http://bgee.unil.ch/"}
@@ -215946,7 +215865,7 @@ is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0035965 ! wall of blood vessel
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/61/Blood_vessels.svg" xsd:anyURI
[Term]
id: UBERON:0004801
@@ -216926,7 +216845,7 @@ xref: Wikipedia:Splanchnopleure
is_a: UBERON:0002050 ! embryonic structure
relationship: overlaps UBERON:0000925 ! endoderm
relationship: part_of UBERON:0003081 {source="EHDAA2"} ! lateral plate mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png" xsd:anyURI
property_value: editor_note "TODO - check relationship to LPM" xsd:string
[Term]
@@ -216945,7 +216864,7 @@ xref: Wikipedia:Somatopleure
is_a: UBERON:0002050 ! embryonic structure
relationship: overlaps UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0003081 {source="EHDAA2"} ! lateral plate mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray16.png" xsd:anyURI
property_value: UBPROP:0000011 "Gives rise to the paired appendages in jawed vertebrates. a persistent somatopleure through the redistribution and expansion of the lateral plate mesoderm is a synapomorphy for gnathostomes and a critical step in generating a novel developmental module with dramatic evolutionary potentia (Tulenko et al. 2012) http://burkelab.research.wesleyan.edu/current-projects/lamprey/" xsd:string
property_value: UBPROP:0000012 "sources differ as to whether this is part-of or develops-from the LPM" xsd:string
@@ -217297,7 +217216,7 @@ is_a: UBERON:0009497 ! epithelium of foregut-midgut junction
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: develops_from UBERON:0004161 {source="EHDAA2-modified"} ! septum transversum
relationship: part_of UBERON:0002423 {source="EHDAA2"} ! hepatobiliary system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png" xsd:anyURI
[Term]
id: UBERON:0004913
@@ -217333,7 +217252,7 @@ intersection_of: part_of UBERON:0004914 ! duodenal papilla
relationship: part_of UBERON:0001174 ! common bile duct
relationship: part_of UBERON:0004914 ! duodenal papilla
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Biliary_system_new.svg" xsd:anyURI
property_value: UBPROP:0000001 "Ampulla formed by the union of the pancreatic duct and the common bile duct where they enter the intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005167", ontology="TAO", source="ZFIN:ZDB-PUB-070212-11", source="ZFIN:ZDB-PUB-080414-12"}
[Term]
@@ -217351,7 +217270,7 @@ xref: NCIT:C119578
xref: SCTID:245389007
is_a: UBERON:0034944 ! zone of organ
relationship: part_of UBERON:0000320 ! duodenal mucosa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb" xsd:string
[Term]
@@ -217379,7 +217298,7 @@ intersection_of: UBERON:0004590 ! sphincter muscle
intersection_of: part_of UBERON:0004913 ! hepatopancreatic ampulla
relationship: part_of UBERON:0004913 ! hepatopancreatic ampulla
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/43/Gray1057.png" xsd:anyURI
[Term]
id: UBERON:0004916
@@ -219197,7 +219116,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: has_part UBERON:0002384 ! connective tissue
relationship: overlaps UBERON:0003728 ! mediastinum
relationship: part_of UBERON:0000473 ! testis
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI
[Term]
id: UBERON:0005055
@@ -219558,7 +219477,7 @@ is_a: UBERON:0000064 ! organ part
relationship: part_of UBERON:0001289 ! descending limb of loop of Henle
relationship: part_of UBERON:0004136 ! intermediate tubule
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/2276" xsd:string
[Term]
@@ -219580,7 +219499,7 @@ is_a: UBERON:0007685 ! region of nephron tubule
is_a: UBERON:0012275 ! meso-epithelium
relationship: develops_from UBERON:0003220 {source="Wikipedia"} ! metanephric mesenchyme
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0005099
@@ -220177,7 +220096,7 @@ disjoint_from: UBERON:0009887 ! interlobar vein
relationship: connected_to UBERON:0004719 ! kidney arcuate vein
relationship: part_of UBERON:0001225 ! cortex of kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray1128.png" xsd:anyURI
[Term]
id: UBERON:0005169
@@ -221265,6 +221184,46 @@ relationship: capable_of_part_of GO:0070293 {source="Wikipedia"} ! renal absorpt
relationship: connected_to UBERON:0004640 ! renal efferent arteriole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+[Term]
+id: UBERON:0005275
+name: dorsal skin of digit
+namespace: uberon
+synonym: "dorsal digit skin" EXACT []
+synonym: "skin of dorsal part of digit" EXACT []
+is_a: UBERON:0015249 ! digit skin
+
+[Term]
+id: UBERON:0005276
+name: dorsal skin of finger
+namespace: uberon
+def: "A dorsal skin of digit that is part of a manual digit." [OBOL:automatic]
+synonym: "dorsal finger skin" EXACT []
+synonym: "skin of dorsal part of finger" EXACT [FMA:38320]
+synonym: "subdivision of skin of dorsal part of finger" EXACT [FMA:60346]
+xref: FMA:38320
+xref: FMA:60346
+is_a: UBERON:0003533 ! manual digit skin
+is_a: UBERON:0005275 ! dorsal skin of digit
+intersection_of: UBERON:0005275 ! dorsal skin of digit
+intersection_of: part_of UBERON:0002389 ! manual digit
+property_value: UBPROP:0000012 "this class is explicitly the union of the two FMA classes" xsd:string {external_ontology="FMA"}
+
+[Term]
+id: UBERON:0005277
+name: dorsal skin of toe
+namespace: uberon
+def: "A dorsal skin of digit that is part of a pedal digit." [OBOL:automatic]
+synonym: "dorsal toe skin" EXACT []
+synonym: "skin of dorsal part of toe" EXACT [FMA:37868]
+synonym: "subdivision of skin of dorsal part of toe" EXACT [FMA:60523]
+xref: FMA:37868
+xref: FMA:60523
+is_a: UBERON:0003530 ! pedal digit skin
+is_a: UBERON:0005275 ! dorsal skin of digit
+intersection_of: UBERON:0005275 ! dorsal skin of digit
+intersection_of: part_of UBERON:0001466 ! pedal digit
+property_value: UBPROP:0000012 "this class is explicitly the union of the two FMA classes" xsd:string {external_ontology="FMA"}
+
[Term]
id: UBERON:0005281
name: ventricular system of central nervous system
@@ -221288,7 +221247,7 @@ xref: Wikipedia:Ventricular_system
xref: ZFA:0001261
is_a: UBERON:0000467 {source="ZFA"} ! anatomical system
relationship: part_of UBERON:0001017 ! central nervous system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
property_value: editor_note "TODO - resolve space vs structure conflation. We follow FMA in making this and the various ventricles a structure - it follows from this that strutures such as the tela choroidea and choroid plexuses can be part of the ventricles and ventricular system. Note: see also the class 'neuraxis cavity'" xsd:string
[Term]
@@ -221398,7 +221357,7 @@ xref: Wikipedia:Myelencephalon
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004733 ! segmental subdivision of hindbrain
relationship: immediate_transformation_of UBERON:0010096 {evidence="definitional"} ! future myelencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:7955
property_value: UBPROP:0000001 "The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000456", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/myelencephalon"}
property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000456", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"}
@@ -221465,7 +221424,7 @@ xref: XAO:0000018
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004876 ! urogenital fold
relationship: part_of UBERON:0004122 ! genitourinary system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1106.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray1106.png" xsd:anyURI
property_value: editor_note "TODO - check developmental relationships. merge with urogenital ridge?" xsd:string
property_value: UBPROP:0000011 "in eutherians, SRY transforms the indifferent gonad into testes" xsd:string
@@ -221572,7 +221531,7 @@ intersection_of: part_of UBERON:0002411 ! clitoris
relationship: adjacent_to UBERON:0006653 ! glans clitoris
relationship: part_of UBERON:0002411 ! clitoris
relationship: transformation_of UBERON:0035006 ! preputial swelling of female
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Clitoris_outer_anatomy.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Clitoris_outer_anatomy.gif" xsd:anyURI
property_value: UBPROP:0000008 "FMA has FMA:27886 skin of prepuce of clitoris" xsd:string
[Term]
@@ -221931,7 +221890,7 @@ is_a: UBERON:0034921 ! multi organ part structure
relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia
relationship: has_part UBERON:0001000 ! vas deferens
relationship: part_of UBERON:0004054 ! internal male genitalia
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI
[Term]
id: UBERON:0005356
@@ -222800,7 +222759,7 @@ xref: SCTID:246901006
xref: Wikipedia:Adipose_capsule_of_kidney
is_a: UBERON:0001013 ! adipose tissue
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/69/Illu_kidney.jpg" xsd:anyURI
property_value: editor_note "TODO - split perinephric / perirenal" xsd:string
[Term]
@@ -222820,7 +222779,7 @@ xref: neuronames:1242
xref: NLXANAT:20090312
xref: Wikipedia:Circumventricular_organs
is_a: UBERON:0002616 ! regional part of brain
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7d/Gray734.png" xsd:anyURI
property_value: UBPROP:0000008 "All vertebrates possess at least 4 circumventricular organs (including the hypothalamus) which can monitor the contents of the cerebrospinal fluid and secrete additional substances into it. (Butler, 1996, p. 330)" xsd:string
property_value: UBPROP:0000010 "CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances" xsd:string
@@ -223256,7 +223215,7 @@ xref: Wikipedia:Common_hepatic_artery
is_a: UBERON:0004573 ! systemic artery
relationship: branching_part_of UBERON:0001640 ! celiac artery
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/65/Gray532.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -223301,7 +223260,7 @@ intersection_of: conduit_for UBERON:0000377 ! maxillary nerve
intersection_of: part_of UBERON:0001677 ! sphenoid bone
relationship: conduit_for UBERON:0000377 ! maxillary nerve
relationship: part_of UBERON:0001677 ! sphenoid bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/35/Gray145.png" xsd:anyURI
property_value: UBPROP:0000001 "A circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.vity. [Wikipedia:Foramen_rotundum][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001543", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "It is suggested that the mammalian lamina ascendens arose from an upgrowth of the root of the quadrate ramus of the epipterygoid in cynodonts, separating foramen rotundum from foramen ovale.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001543", ontology="VHOG", source="PMID:1018003 Presley R, Steel FLD, On the homology of the alisphenoid. Journal of Anatomy (1976)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "todo - check placement of AAO class" xsd:string {external_ontology="AAO"}
@@ -223351,7 +223310,7 @@ relationship: conduit_for UBERON:0001586 ! internal jugular vein
relationship: conduit_for UBERON:0001759 ! vagus nerve
relationship: conduit_for UBERON:0002019 ! accessory XI nerve
relationship: part_of UBERON:0001678 ! temporal bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Foramenjugulare.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Foramenjugulare.PNG" xsd:anyURI
property_value: UBPROP:0000001 "Large foramen that houses the glossopharyngeal and vagus nerves and is located inside the condyloid fossa.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000249", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000001 "One of a pair of openings between the lateral part of the occipital bone and the petrous part of the temporal bones in the skull. The foramen contains the inferior petrosal sinus; the transverse sinus; some meningeal branches of the occipital and ascending pharyngeal arteries; and the glossopharyngeal, vagus, and accessory nerves. [Free_Online_Medical_Dictionary]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001113", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/jugular+foramen"}
property_value: UBPROP:0000002 "relationship loss: subclass braincase and otic capsule opening (AAO:0000051)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000249", ontology="AAO"}
@@ -223452,7 +223411,7 @@ relationship: has_muscle_origin UBERON:0001077 {notes="Posterior tubercles of tr
relationship: innervated_by UBERON:0000962 {notes="cervical nerve and dorsal scapular nerve", source="dbpedia"} ! nerve of cervical vertebra
relationship: part_of UBERON:0008713 {source="EHDAA2"} ! pectoral girdle and thoracic body wall skeletal muscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bc/Levator_scapulae.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/bc/Levator_scapulae.png" xsd:anyURI
[Term]
id: UBERON:0005463
@@ -223483,7 +223442,7 @@ relationship: adjacent_to UBERON:0002006 ! cortex of lymph node
relationship: adjacent_to UBERON:0002194 ! capsule of lymph node
relationship: part_of UBERON:0000029 ! lymph node
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray597.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/68/Gray597.png" xsd:anyURI
[Term]
id: UBERON:0005469
@@ -223639,7 +223598,7 @@ intersection_of: located_in UBERON:0002363 ! dura mater
relationship: located_in UBERON:0002363 ! dura mater
relationship: part_of UBERON:0003711 {source="FMA"} ! brachiocephalic vein
relationship: part_of UBERON:0010743 ! meningeal cluster
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/b/bd/Gray488_blue.gif" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/b/bd/Gray488_blue.gif" xsd:anyURI
property_value: editor_note "the MA placement should be checked" xsd:string
[Term]
@@ -223671,7 +223630,7 @@ is_a: UBERON:0013140 ! systemic vein
intersection_of: UBERON:0001638 ! vein
intersection_of: drains UBERON:0001040 ! yolk sac
relationship: drains UBERON:0001040 ! yolk sac
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray475.png" xsd:anyURI
property_value: UBPROP:0000001 "One of two veins that run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal, and beyond this are connected to one another by two anastomotic branches, one on the dorsal, and the other on the ventral aspect of the duodenal portion of the intestine, which is thus encircled by two venous rings; into the middle or dorsal anastomosis the superior mesenteric vein opens. The portions of the veins above the upper ring become interrupted by the developing liver and broken up by it into a plexus of small capillary-like vessels termed sinusoids.[XAO]" xsd:string {ontology="XAO", source="XAO:0004147"}
property_value: UBPROP:0000003 "Within each vertebrate group, the veins compose a few main functional systems that arise embryologically from what seems to be a common developmental pattern. (...) Early in development, three major sets of paired veins are present: the vitelline veins from the yolk sac, the cardinal veins from the body of the embryo itself, and the lateral abdominal veins from the pelvic region. The paired vitelline veins are among the first vessels to appear in the embryo. They arise over the yolk and follow the yolk stalk into the body. They then turn anteriorly, continue along the gut, and enter the sinus venosus.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000401", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.460", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "check zfa (no text def). Check vitelline/omphalomesenteric distinction in XAO" xsd:string {external_ontology="XAO"}
@@ -224206,7 +224165,7 @@ xref: VHOG:0000351
xref: ZFA:0005133
is_a: UBERON:0003281 ! mesentery of stomach
relationship: part_of UBERON:0009668 {source="EHDAA2"} ! ventral mesentery
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray984.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/cf/Gray984.png" xsd:anyURI
property_value: UBPROP:0000001 "The mesentery that originates from the ventral side of the peritoneal cavity.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005133", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The ventral sheet of the primitive mesentery that encloses the stomach. The lesser omentum develops from the ventral mesogastrium. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000351", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/mesogastrium"}
@@ -224821,7 +224780,7 @@ is_a: UBERON:0004797 {source="cjm"} ! blood vessel layer
is_a: UBERON:0005742 ! adventitia
relationship: composed_primarily_of UBERON:0011824 ! fibrous connective tissue
relationship: has_quality PATO:0002462 ! collagenous
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/32/Illu_artery.jpg" xsd:anyURI
property_value: editor_note "TODO - note terminological problems. WP says tunica external layer of blood vessel. FMA says tunica externa = adventitia, and is FMA adventitia covers other kinds of vessels. Here we opt for a lengthier name that attempts to disambiguate. There is no precise FMA equivalent, as FMA has tunica externa of arteries, veins, genital ducts etc as siblings" xsd:string
property_value: UBPROP:0000001 "The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]." xsd:string {source="Wikipedia:Tunica_externa_(vessels)"}
@@ -224860,7 +224819,7 @@ xref: Wikipedia:Adventitia
is_a: UBERON:0004923 ! organ component layer
relationship: composed_primarily_of UBERON:0002384 ! connective tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg" xsd:anyURI
[Term]
id: UBERON:0005744
@@ -224877,7 +224836,7 @@ is_a: UBERON:0004111 ! anatomical conduit
intersection_of: UBERON:0004111 ! anatomical conduit
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray193.png" xsd:anyURI
property_value: UBPROP:0000012 "in FMA and ZFA this is a conduit space, not a conduit. Note there may be some additional disambiguation required: foramen is used loosely in the sense of any opening (e.g. foramen primum). FMA appears to use cranial conduit (undefined) in the sense of any foramen of the skull (includes mental foramen, which is not in the cranium proper)." xsd:string {external_ontology="FMA"}
[Term]
@@ -224913,7 +224872,7 @@ relationship: conduit_for UBERON:0000941 ! cranial nerve II
relationship: conduit_for UBERON:0001619 ! ophthalmic artery
relationship: in_lateral_side_of UBERON:0001677 {source="FMA-abduced-lr"} ! sphenoid bone
relationship: part_of UBERON:0002478 ! orbitosphenoid
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8e/Orbita_mensch.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8e/Orbita_mensch.jpg" xsd:anyURI
property_value: UBPROP:0000001 "An aperture in the root of the lesser wing of the sphenoid bone transmitting the optic nerve. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001408", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/optic+foramen"}
property_value: UBPROP:0000001 "Foramen in the orbital region of the neurocranium for the passage of the optic nerve (cranial nerve II).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002025", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000001 "The short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery" xsd:string {external_class="MP:0010704", ontology="MP"}
@@ -225047,7 +225006,7 @@ is_a: UBERON:0003037 ! septum
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0001008 {source="MA"} ! renal system
relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray992.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray992.png" xsd:anyURI
property_value: editor_note "todo - use to define cloacal septation in GO" xsd:string
property_value: UBPROP:0000001 "A ridge of mesoderm covered with endoderm that in the early developing embryo divides the endodermal cloaca into the urogenital sinus and the rectum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000018", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/urorectal+septum"}
property_value: UBPROP:0000003 "In mammals the lowly monotremes still have a cloaca. Higher types have done away with this structure and have a separate anal outlet for the rectum. The monotreme cloaca shows the initiation of this subdivision. The cloaca has such includes only the distal part, roughly comparable to the proctodeum. The more proximal part is divided into (1) a large dorsal passage into which the intestine opens, the coprodeum, and (2) a ventral portion, the urodeum with which the bladder connects. (...) the development of the placental mammals recapitulates in many respects the phylogenetic story. In the sexually indifferent stage of placental mammal there is a cloaca. While the indifferent stage still persists, a septum develops, and extends out to the closing membrane. This divides the cloaca into two chambers: a coprodeum continuous with the gut above, and a urodeum or urogenital sinus below.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000018", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.388-89 and Figure 300", source="http://bgee.unil.ch/"}
@@ -225118,7 +225077,7 @@ intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: part_of UBERON:0000074 ! renal glomerulus
relationship: capable_of GO:0003094 ! glomerular filtration
relationship: part_of UBERON:0004188 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! glomerular epithelium
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/de/PhysiologieGlom%C3%A9rulaire.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/de/PhysiologieGlom%C3%A9rulaire.png" xsd:anyURI
property_value: UBPROP:0000001 "Membrane between the mesonephric podocytes and the renal glomerular capillaries. It is a trilaminar structure composed of the fused basement membranes of the glomerular capillaries and basement membrane of the podocytes. The capillary membranes touch the GBM at contact points that are separated by pores. The membrane is semi-permeable allowing water and small molecules to pass into the renal capsular space.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005285", ontology="TAO", source="ZFIN:ZDB-PUB-000824-1"}
[Term]
@@ -225255,7 +225214,7 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0001917 ! endothelium of artery
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0002201 ! vasculature of trunk
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray459.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fb/Gray459.png" xsd:anyURI
property_value: UBPROP:0000001 "Each primitive aorta receives anteriorly a vein 'the vitelline vein' from the yolk-sac, and is prolonged backward on the lateral aspect of the notochord under the name of the dorsal aorta. The dorsal aortae give branches to the yolk-sac, and are continued backward through the body-stalk as the umbilical arteries to the villi of the chorion. The two dorsal aortae combine to become the descending aorta in later development[WP]." xsd:string {source="Wikipedia:Dorsal_aorta"}
property_value: UBPROP:0000001 "Principal unpaired, median artery of the trunk, leading from the paired roots (radices) of the dorsal aorta to the caudal artery. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000014", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The artery in vertebrate embryos that transports blood from the aortic arches to the trunk and limbs. In adult fish it is a major artery that carries oxygenated blood from the efferent branchial arteries to branches that supply the body organ. In adult tetrapods it arises from the systemic arch" xsd:string {source="BTO:0004673"}
@@ -225496,7 +225455,7 @@ xref: UMLS:C1513037 {source="ncithesaurus:Maxillary_Prominence"}
xref: Wikipedia:Maxillary_prominence
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0007238 ! 1st arch maxillary component
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
[Term]
id: UBERON:0005870
@@ -225649,7 +225608,7 @@ relationship: develops_from UBERON:0004874 ! somatopleure
relationship: has_potential_to_develop_into UBERON:0011757 ! differentiated genital tubercle
relationship: only_in_taxon NCBITaxon:32524 {source="https://github.com/obophenotype/uberon/issues/1230"} ! Amniota
relationship: part_of UBERON:0009196 {source="EHDAA2"} ! indifferent external genitalia
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d6/Gray1119.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d6/Gray1119.png" xsd:anyURI
property_value: UBPROP:0000001 "embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until ~E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP]" xsd:string {ontology="MP"}
property_value: UBPROP:0000001 "The eminence in the embryo which develops into the clitoris or penis. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000583", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/genital+tubercle"}
property_value: UBPROP:0000003 "In mammalian embryos, male and female external genitalia develop from the genital tubercle.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000583", ontology="VHOG", source="DOI:10.1242/dev.036830 Seifert AW, Yamaguchi T, Cohn MJ, Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development (2009)", source="http://bgee.unil.ch/"}
@@ -225683,7 +225642,7 @@ is_a: UBERON:0006846 {source="EHDAA2"} ! surface groove
relationship: adjacent_to UBERON:0004117 ! pharyngeal pouch
relationship: overlaps UBERON:0002539 ! pharyngeal arch
relationship: part_of UBERON:0016545 ! pharyngeal ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/20/Kiemenbogen.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/20/Kiemenbogen.jpg" xsd:anyURI
property_value: editor_note "Note we use overlaps as the relationship to the arches" xsd:string
property_value: UBPROP:0000012 "EMAPA distinguishes between the groove ectoderm and epithelium, with the latter arising after the former" xsd:string {external_ontology="EMAPA"}
@@ -225716,7 +225675,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: dorsal_to UBERON:0005478 ! sulcus limitans of neural tube
relationship: has_part CL:0000101 ! sensory neuron
relationship: part_of UBERON:0004061 ! neural tube mantle layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray646.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Gray646.png" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/336" xsd:anyURI
[Term]
@@ -225866,7 +225825,7 @@ intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: channel_for UBERON:0010143 ! seminal vesicle fluid
relationship: channels_into UBERON:0000999 ! ejaculatory duct
relationship: part_of UBERON:0000998 ! seminal vesicle
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1160.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray1160.png" xsd:anyURI
[Term]
id: UBERON:0005904
@@ -226072,7 +226031,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -226226,7 +226185,7 @@ relationship: has_part CL:0002367 ! trabecular meshwork cell
relationship: overlaps UBERON:0006206 ! iridocorneal angle
relationship: part_of UBERON:0003956 ! aqueous drainage system
relationship: surrounds UBERON:0001766 ! anterior chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray870.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/22/Gray870.png" xsd:anyURI
property_value: editor_note "TODO check syns - ligaments" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb" xsd:string
@@ -226400,7 +226359,7 @@ intersection_of: UBERON:0001637 ! artery
intersection_of: supplies UBERON:0001040 ! yolk sac
relationship: branching_part_of UBERON:0005805 {notes="ventral branch"} ! dorsal aorta
relationship: supplies UBERON:0001040 ! yolk sac
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray31.png" xsd:anyURI
[Term]
id: UBERON:0006003
@@ -226943,7 +226902,7 @@ intersection_of: adjacent_to UBERON:0005805 ! dorsal aorta
relationship: adjacent_to UBERON:0002333 ! pulmonary trunk
relationship: adjacent_to UBERON:0005805 ! dorsal aorta
relationship: develops_from UBERON:0000095 {source="PMID:6844926", source="Wikipedia"} ! cardiac neural crest
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray470.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b9/Gray470.png" xsd:anyURI
[Term]
id: UBERON:0006208
@@ -227000,7 +226959,7 @@ relationship: overlaps UBERON:0000930 ! stomodeum
relationship: overlaps UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0006264 {source="EHDAA2"} ! mouth-foregut junction
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
[Term]
id: UBERON:0006213
@@ -227098,7 +227057,7 @@ relationship: develops_from UBERON:0004341 {source="Wikipedia"} ! primitive stre
relationship: has_developmental_contribution_from UBERON:0000924 ! ectoderm
relationship: has_developmental_contribution_from UBERON:0000925 ! endoderm
relationship: part_of UBERON:0000163 ! embryonic cloaca
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray991.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d2/Gray991.png" xsd:anyURI
property_value: UBPROP:0000001 "A membrane that separates the proctodeum and the hindgut in the early embryo. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Vertebrates:_Comparative_Anatomy, p.497, see_Kardong_KV][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001198", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "In mammals, the cloaca exists as an embryonic structure that undergoes septation to become distinct urethral, anal, and genital orifices.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001198", ontology="VHOG", source="PMID:11830557 De Santa Barbara P, Roberts DJ, Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role for Hoxa13. Development (2002)", source="http://bgee.unil.ch/"}
@@ -227558,7 +227517,7 @@ relationship: adjacent_to UBERON:0004067 ! lateral nasal prominence
relationship: adjacent_to UBERON:0005868 ! maxillary prominence
relationship: develops_from UBERON:0012313 {source="EHDAA2"} ! 1st arch maxillary ectoderm
relationship: part_of UBERON:0000076 {source="EHDAA2"} ! external ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray163.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3f/Gray163.png" xsd:anyURI
[Term]
id: UBERON:0006267
@@ -228518,7 +228477,7 @@ intersection_of: connects UBERON:0001046 ! hindgut
relationship: connects UBERON:0000931 ! proctodeum
relationship: connects UBERON:0001046 ! hindgut
relationship: part_of UBERON:0000159 ! anal canal
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7b/Hemorrhoid.png" xsd:anyURI
property_value: UBPROP:0000012 "FMA also has FMA:29321 but it's not clear how this differs" xsd:string {external_ontology="FMA"}
[Term]
@@ -228681,7 +228640,7 @@ intersection_of: UBERON:0002213 ! cartilaginous joint
intersection_of: connects UBERON:0004742 {cardinality="2"} ! dentary
relationship: connects UBERON:0004742 {notes="connects adjacent mandibles"} ! dentary
relationship: part_of UBERON:0001710 ! lower jaw region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png" xsd:anyURI
property_value: editor_note "this is placed as part of lower jaw region, as in this ontology the skeleton does not include joints" xsd:string
property_value: UBPROP:0000001 "Joint that articulates the left and right dentary bones. Mandibular symphysis is unpaired.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001851", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000008 "in snakes, the mandibular symphysis is composed of soft tissues, allowing independent movement of each mandible" xsd:string {source="ISBN:0073040584"}
@@ -228705,7 +228664,7 @@ xref: ZFA:0005652
is_a: UBERON:0000158 {source="FMA"} ! membranous layer
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: part_of UBERON:0001630 {source="FMA"} ! muscle organ
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Aponeurosis.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e6/Aponeurosis.png" xsd:anyURI
property_value: UBPROP:0000001 "Aponeuroses are layers of flat broad tendons. They have a shiny, whitish-silvery color, and are histologically similar to tendons, but are very sparingly supplied with blood vessels and nerves. When dissected, aponeuroses are papery, and peel off by sections. The primary regions with thick aponeurosis is in the ventral abdominal region, the dorsal lumbar region, and in the palmar region. Their primary function is to join muscles and the body parts the muscles act upon[Wikipedia:Aponeurosis]." xsd:string {source="Wikipedia:Aponeurosis"}
property_value: UBPROP:0000012 "in ZFA, aponeuroses are subtypes of tendons, but this is inconsistent with tendons being muscle-bone connections" xsd:string {external_ontology="ZFA"}
@@ -228901,7 +228860,7 @@ intersection_of: UBERON:0035651 ! glans
intersection_of: part_of UBERON:0002411 ! clitoris
relationship: develops_from UBERON:0013240 {source="cjm"} ! future glans clitoris
relationship: part_of UBERON:0002411 ! clitoris
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Clitoris_inner_anatomy.gif" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8c/Clitoris_inner_anatomy.gif" xsd:anyURI
[Term]
id: UBERON:0006657
@@ -228926,7 +228885,7 @@ xref: Wikipedia:Glenoid_cavity
is_a: UBERON:0004704 ! bone fossa
relationship: adjacent_to UBERON:0006849 {notes="to be revised after scapulocoracoid fixes"} ! scapula
relationship: part_of UBERON:0004753 ! scapulocoracoid
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray328.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ec/Gray328.png" xsd:anyURI
property_value: UBPROP:0000001 "Cavity for the articulation of the forelimb formed by the scapula, coracoid, and clavicle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000749", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: part_of scapular area (AAO:0000935)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000749", ontology="AAO"}
property_value: UBPROP:0000008 "The glenoid fossa can be associated with the metapterygium in sarcopterygians, or either the meso- or propterygium in basal gnathostomes such as Chondrichthyans" xsd:string {source="ad"}
@@ -229001,7 +228960,7 @@ xref: SCTID:368677009
xref: Wikipedia:Galea_aponeurotica
is_a: UBERON:0006614 ! aponeurosis
relationship: part_of UBERON:0000403 {source="FMA"} ! scalp
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fa/Gray378.png" xsd:anyURI
[Term]
id: UBERON:0006668
@@ -229017,7 +228976,7 @@ intersection_of: UBERON:0013685 ! foramen of skull
intersection_of: conduit_for UBERON:0001532 ! internal carotid artery
relationship: conduit_for UBERON:0001532 ! internal carotid artery
relationship: part_of UBERON:0001678 ! temporal bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Gray141.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4c/Gray141.png" xsd:anyURI
[Term]
id: UBERON:0006670
@@ -229133,7 +229092,7 @@ relationship: conduit_for UBERON:0002240 ! spinal cord
relationship: lumen_of UBERON:0001130 ! vertebral column
relationship: part_of UBERON:0001130 ! vertebral column
relationship: surrounds UBERON:0002240 ! spinal cord
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray82.png" xsd:anyURI
property_value: editor_note "TODO - check neural vs vertebral canal; embryonic vs adult?" xsd:string
property_value: UBPROP:0000001 "Canal formed by the vertebral centra ventrally, the pedicels laterally, and the neural arches dorsally that encloses and protects the spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000693", ontology="AAO", source="AAO:LAP"}
@@ -229213,7 +229172,7 @@ xref: Wikipedia:Modiolus_(cochlea)
is_a: UBERON:0005913 ! zone of bone organ
relationship: contributes_to_morphology_of UBERON:0001844 ! cochlea
relationship: part_of UBERON:0007223 {source="MA"} ! osseus cochlea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/16/Gray921.png" xsd:anyURI
[Term]
id: UBERON:0006725
@@ -229259,7 +229218,7 @@ xref: Wikipedia:Tuberculum_impar
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0006260 {source="EHDAA2"} ! lingual swellings
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png" xsd:anyURI
property_value: UBPROP:0000003 "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000730", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2002.00073.x", source="http://bgee.unil.ch/"}
[Term]
@@ -229279,7 +229238,7 @@ xref: Wikipedia:Lateral_lingual_swelling
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0006260 ! lingual swellings
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5c/Gray979.png" xsd:anyURI
property_value: UBPROP:0000003 "Most adult amphibians have a tongue, as do all known reptiles, birds and mammals. Thus it is likely that the tongue appeared with the establishment of tetrapods and this structure seems to be related, to some extant, to the terrestrial lifestyle.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000731", ontology="VHOG", source="DOI:10.1046/j.1469-7580.2002.00073.x Iwasaki S, Evolution of the structure and function of the vertebrate tongue. J Anat (2002)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000010 "paired" xsd:string
@@ -229317,7 +229276,7 @@ relationship: connects UBERON:0000964 ! cornea
relationship: connects UBERON:0001773 ! sclera
relationship: part_of UBERON:0000019 ! camera-type eye
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png" xsd:anyURI
[Term]
id: UBERON:0006763
@@ -229551,7 +229510,7 @@ relationship: overlaps UBERON:0001470 {gci_relation="part_of", gci_filler="NCBIT
relationship: overlaps UBERON:0003692 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! acromioclavicular joint
relationship: part_of UBERON:0001467 {gci_relation="part_of", gci_filler="NCBITaxon:32523", source="FMA"} ! shoulder
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/59/Pectoral_girdles-en.svg" xsd:anyURI
property_value: UBPROP:0000001 "Endochondral bone that is located medial to the cleithrum, and articulates ventrally with the coracoid, medially with the mesocoracoid when the later is present and posteriorly with the upper one to three proximal radials. The scapula develops from the scapulocoracoid cartilage and belongs to the primary pectoral girdle. It may be perforated by the scapular foramen or it may be notched ventr and forms together with a similar notch of the coracoid the scapulocoracoid foramen[TAO:0000583]." xsd:string {source="TAO:0000583"}
property_value: UBPROP:0000001 "Paired bony elements of endochondral origin. They are situated at the level of the jaw articulation, in a vertical position, with the suprascapular margin being dorsal and the glenoid end being ventral.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000751", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: has pars glenoidalis of scapula (AAO:0000753)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000751", ontology="AAO"}
@@ -229681,7 +229640,7 @@ is_a: UBERON:0004769 ! diaphysis
intersection_of: UBERON:0004769 ! diaphysis
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0000981 ! femur
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray244.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2b/Gray244.png" xsd:anyURI
property_value: UBPROP:0000001 "The body of the femur (or shaft), almost cylindrical in form, is a little broader above than in the center, broadest and somewhat flattened from before backward below. It is slightly arched, so as to be convex in front, and concave behind, where it is strengthened by a prominent longitudinal ridge, the linea aspera. It presents for examination three borders, separating three surfaces. Of the borders, one, the linea aspera, is posterior, one is medial, and the other, lateral[Wikipedia:Body_of_femur]." xsd:string {source="Wikipedia:Body_of_femur"}
[Term]
@@ -230269,7 +230228,7 @@ relationship: channels_from UBERON:0003959 ! rete testis
relationship: channels_into UBERON:0001301 ! epididymis
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0006947 {source="FMA"} ! male genital duct
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b5/Hodenschema.svg" xsd:anyURI
property_value: UBPROP:0000001 "Any of a group ranging from one to twelve (varies in species) small seminal ducts per testis which transport sperm from the testes to the kidney.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010532", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000008 "There are two basic designs for efferent ductule structure: a) multiple entries into the epididymis, as seen in most large mammals. In humans and other large mammals, there are approximately 15-20 efferent ducts, which also occupy nearly one third of the head of the epididymis. b) single entry, as seen in most small animals such as rodents, whereby the 3-6 ductules merge into a single small ductule prior to entering the epididymis" xsd:string
property_value: UBPROP:0000012 "Check EMAPA" xsd:string {external_ontology="EMAPA"}
@@ -230662,7 +230621,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004027 {source="MP-def"} ! chorionic plate
relationship: part_of UBERON:0003124 {source="BTO"} ! chorion membrane
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Gray29.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Gray29.png" xsd:anyURI
property_value: UBPROP:0000008 "The mouse and human placentas have labyrinthine and villous types of interdigitation between maternal and fetal tissues, respectively" xsd:string
property_value: UBPROP:0000010 "The bulk of the villi consist of connective tissues in which blood vessels are found. Most of the cells in the connective tissue core of the villi are fibroblasts. Macrophages known as Hofbauer cells are also present." xsd:string
@@ -230691,7 +230650,7 @@ intersection_of: UBERON:0001560 ! neck of organ
intersection_of: part_of UBERON:0000981 ! femur
relationship: part_of UBERON:0006863 ! proximal metaphysis of femur
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray243.png" xsd:anyURI
[Term]
id: UBERON:0007122
@@ -232012,7 +231971,7 @@ relationship: contributes_to_morphology_of UBERON:0000017 ! exocrine pancreas
relationship: develops_from UBERON:0003922 ! pancreatic epithelial bud
relationship: part_of UBERON:0000017 {source="MA"} ! exocrine pancreas
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI
property_value: IAO:0000232 "this class groups together accessory (dorsal) and main (ventral) pancreatic ducts" xsd:string
property_value: UBPROP:0000001 "Duct connecting the pancreas with the intestine. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000254", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000254", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", source="http://bgee.unil.ch/"}
@@ -232636,7 +232595,7 @@ xref: Wikipedia:Trigeminal_nerve_nuclei
is_a: UBERON:0007245 {source="FMA"} ! nuclear complex of neuraxis
relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve
relationship: overlaps UBERON:0003023 {source="FMA"} ! pontine tegmentum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI
property_value: UBPROP:0000012 "in MA and FMA this is part of the pons / pontime tegmentum. We weaken this to overlaps to avoid inconsistency. In NIF this is a composite structure spanning multiple regions, which is more appropriate." xsd:string {external_ontology="MA"}
[Term]
@@ -232837,7 +232796,7 @@ intersection_of: UBERON:0000161 ! orifice
intersection_of: part_of UBERON:0001727 ! taste bud
relationship: continuous_with UBERON:0000167 ! oral cavity
relationship: part_of UBERON:0001727 {source="FMA"} ! taste bud
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/0e/Taste_bud.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/0/0e/Taste_bud.svg" xsd:anyURI
[Term]
id: UBERON:0007692
@@ -233301,7 +233260,7 @@ intersection_of: skeleton_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0012475 ! skeleton of pectoral complex
relationship: skeleton_of UBERON:0001421 ! pectoral girdle region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/22/Pectoral_girdle_front_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/22/Pectoral_girdle_front_diagram.svg" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical cluster of paired dermal and endochondral bones that attaches to the dorso-posterior part of the cranium, and support the radials and pectoral fin. It consists of two components: the primary pectoral girdle consisting of the endochondral coracoid, scapula and mesocoracoid bones, and the secondary pectoral girdle consisting of the dermal posttemporal, supracleithrum, cleithrum and poscleithrum(thra) bones.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000407", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000001 "Girdle skeleton consisting of a set of bones linking the axial series to the forelimb/fin skeleton and offering anchoring areas for forelimb/fin and caudal musculature.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000156", ontology="VSAO", source="https://orcid.org/0000-0002-6601-2165"}
property_value: UBPROP:0000001 "Skeletal structure immediately behind the head attached to the vertebral column by muscles and supporting the forelimbs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000422", ontology="AAO", source="AAO:LAP"}
@@ -233345,7 +233304,7 @@ relationship: develops_from UBERON:0010377 {source="PMID:21455939"} ! mesenchyme
relationship: part_of UBERON:0001271 ! pelvic girdle region
relationship: part_of UBERON:0012476 ! skeleton of pelvic complex
relationship: skeleton_of UBERON:0001271 ! pelvic girdle region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray242.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fe/Gray242.png" xsd:anyURI
property_value: editor_note "need to resolve whether this is a paired structure or a single belt (Paired in FMA - implicitly paired in VSAO)" xsd:string
property_value: UBPROP:0000001 "Anatomical cluster by which the hind limbs are supported and attached to the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000426", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000001 "Anatomical cluster that consists of the paired basipterygia which support the pelvic fin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000565", ontology="TAO", source="TAO:wd"}
@@ -233553,6 +233512,25 @@ intersection_of: part_of UBERON:0001421 ! pectoral girdle region
relationship: part_of UBERON:0004471 ! musculature of pectoral girdle
property_value: UBPROP:0000012 "EMAPA has both non-skeletal and skeletal types, with the non-skeletal also including a chest muscle, so we place the skeletal class here as the most accurate" xsd:string {external_ontology="EMAPA"}
+[Term]
+id: UBERON:0008198
+name: nail plate
+namespace: uberon
+def: "The nail plate is the hard and translucent portion of the nail, composed of keratin." [https://github.com/obophenotype/uberon/issues/20, https://sourceforge.net/p/geneontology/ontology-requests/8479/, Wikipedia:Nail_plate]
+subset: human_reference_atlas
+synonym: "lamina unguis" RELATED LATIN [Wikipedia:Nail_plate]
+xref: EMAPA:35583
+xref: MA:0002708
+xref: NCIT:C34216
+xref: SCTID:372177002
+xref: Wikipedia:Nail_plate
+is_a: UBERON:0013754 ! integumentary system layer
+relationship: has_part CL:0000312 ! keratinocyte
+relationship: part_of UBERON:0001705 {source="MA"} ! nail
+relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/9f/Fingernail_label.jpg" xsd:anyURI
+property_value: UBPROP:0000012 "in FMA, the nail is the nail plate" xsd:string {external_ontology="FMA"}
+
[Term]
id: UBERON:0008202
name: bone of hip region
@@ -233587,7 +233565,7 @@ intersection_of: luminal_space_of UBERON:0002355 ! pelvic region of trunk
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0002355 ! pelvic region of trunk
relationship: part_of UBERON:0035819 ! abdominopelvic cavity
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
[Term]
id: UBERON:0008229
@@ -233705,7 +233683,7 @@ intersection_of: part_of UBERON:0001758 ! periodontium
relationship: develops_from UBERON:0008969 {source="PMID:19767574", source="Wikipedia:Dental_follicle"} ! dental follicle
relationship: part_of UBERON:0001758 {source="BTO"} ! periodontium
relationship: seeAlso FMA:76870
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/dc/The_Periodontium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The collagen fibers, running from the cementum to the alveolar bone, that suspend a tooth in its socket; they include apical, oblique, horizontal, and alveolar crest fibers, indicating that the orientation of the fibers varies at different levels[http://www.drugs.com/dict/desmodentium.html]." xsd:string {source="http://www.drugs.com/dict/desmodentium.html"}
property_value: UBPROP:0000001 "The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO]. It consist of cells, extracellular compartment of fibers. The cells are fibroblast, epithelial, undifferentiated mesenchymal cells, bone and cementum cells. The extracellular compartment consists of collagen fibers bundles embedded in ground substance. The PDL substance has been estimated to be 70% water and is thought to have a significant effect on the tooth's ability to withstand stress loads[WP][BTO:0001020, Wikipedia:Periodontal_fiber, https://github.com/obophenotype/uberon/issues/21]." xsd:string {source="Wikipedia:Periodontal_fiber"}
property_value: UBPROP:0000012 "FMA treats periodontium and periodontal ligament as the same; it has a separate class desmodentium, which we place here even though it is classified as fetal in FMA" xsd:string {external_ontology="FMA"}
@@ -233827,7 +233805,7 @@ is_a: UBERON:0005445 {source="FMA"} ! segment of pes
is_a: UBERON:0008837 ! palmar/plantar part of autopod
intersection_of: UBERON:0008837 ! palmar/plantar part of autopod
intersection_of: part_of UBERON:0002387 ! pes
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/41/Soles2.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/41/Soles2.jpg" xsd:anyURI
property_value: UBPROP:0000008 "In humans is the sole of the foot anatomically referred to as the plantar aspect. The equivalent surface in ungulates is the hoof" xsd:string
[Term]
@@ -234072,7 +234050,7 @@ intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: connects UBERON:0001447 {cardinality="2"} ! tarsal bone
relationship: connects UBERON:0001447 {notes="two adjacent tarsals"} ! tarsal bone
relationship: part_of UBERON:0004454 ! tarsal region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray360.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray360.png" xsd:anyURI
[Term]
id: UBERON:0008522
@@ -234204,7 +234182,7 @@ relationship: connected_to UBERON:0001545 ! anterior tibial vein
relationship: connected_to UBERON:0001547 ! small saphenous vein
relationship: connected_to UBERON:0001550 ! medial marginal vein
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Gray581.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Gray581.png" xsd:anyURI
[Term]
id: UBERON:0008784
@@ -234269,7 +234247,7 @@ relationship: adjacent_to UBERON:0001091 ! calcareous tooth
relationship: adjacent_to UBERON:0001828 ! gingiva
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0000165 ! mouth
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/5/5e/Gingival_sulcus.PNG" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/5/5e/Gingival_sulcus.PNG" xsd:anyURI
[Term]
id: UBERON:0008811
@@ -234419,7 +234397,7 @@ is_a: UBERON:0009497 ! epithelium of foregut-midgut junction
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: develops_from UBERON:0003894 {source="EHDAA2"} ! liver primordium
relationship: part_of UBERON:0004161 {notes="caudal part", source="EHDAA2"} ! septum transversum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4f/Gray1088.png" xsd:anyURI
property_value: UBPROP:0000008 "in mice, the hepatic diverticulum forms by E9 and expands into an obvious liver bud by E10" xsd:string
property_value: UBPROP:0000011 "The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut." xsd:string
@@ -234486,7 +234464,7 @@ relationship: connects UBERON:0004765 {notes="bones or cartilage organs"} ! skel
relationship: has_part CL:0000057 {source="AEO"} ! fibroblast
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: part_of UBERON:0001434 ! skeletal system
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
property_value: editor_note "logical definition deliberately made strict to avoid classifying MA:spiral ligament as both nonskeletal and skeletal. see https://github.com/obophenotype/mouse-anatomy-ontology/issues/71" xsd:string
property_value: UBPROP:0000001 "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000072", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Ligament organ that primarily consists of regular dense connective tissue aggregated into fasciculi; connects bone and cartilage organs. Examples: sutural ligament, ligament of pinna, tarsal ligament[FMA:25624]." xsd:string {source="FMA:25624"}
@@ -234545,7 +234523,7 @@ relationship: continuous_with UBERON:0001165 ! pyloric antrum
relationship: continuous_with UBERON:0001202 ! pyloric sphincter
relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus
relationship: part_of UBERON:0001166 {source="Wikipedia"} ! pylorus
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/33/Illu_stomach.jpg" xsd:anyURI
[Term]
id: UBERON:0008859
@@ -234596,7 +234574,7 @@ intersection_of: part_of UBERON:0001166 ! pylorus
relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus
relationship: has_quality PATO:0002299 {source="Wikipedia:Tubular_gland"} ! tubular
relationship: part_of UBERON:0004998 ! mucosa of pylorus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bf/Gray1054.png" xsd:anyURI
property_value: editor_note "check relationship to pylorus vs antrum" xsd:string
[Term]
@@ -234706,7 +234684,7 @@ xref: VSAO:0000046
xref: Wikipedia:Osteoid
xref: XAO:0004035
is_a: UBERON:0002481 {source="VSAO"} ! bone tissue
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/9/9c/Active_osteoblasts.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/9/9c/Active_osteoblasts.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000046", ontology="VSAO", source="GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalci[ISBN:0-683-40008-8]n" xsd:string {reference="ISBN:0-683-40008-8", source="MP:0010924"}
property_value: UBPROP:0000012 "Note that in VSAO this was classified both as tissue and acellular extracellular matrix. Consider also the AEO class 'bone condensation'. is_a intercellular matrix in FMA." xsd:string {external_ontology="VSAO"}
@@ -234774,7 +234752,7 @@ is_a: UBERON:0001593 {source="FMA"} ! venous plexus
intersection_of: UBERON:0001593 ! venous plexus
intersection_of: surrounds UBERON:0001052 ! rectum
relationship: surrounds UBERON:0001052 ! rectum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray587.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/69/Gray587.png" xsd:anyURI
[Term]
id: UBERON:0008895
@@ -234805,7 +234783,7 @@ relationship: develops_from UBERON:0002539 {source="https://github.com/obophenot
relationship: has_developmental_contribution_from UBERON:0003099 {notes="redundant", source="Grays", source="PMID:11237469"} ! cranial neural crest
relationship: overlaps UBERON:0011156 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! facial skeleton
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001216", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010157", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000315", ontology="VHOG", source="http://bgee.unil.ch/"}
@@ -235202,7 +235180,7 @@ intersection_of: UBERON:0011148 ! submucosal gland
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: located_in UBERON:0001972 ! submucosa of esophagus
relationship: part_of UBERON:0001043 ! esophagus
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg" xsd:anyURI
[Term]
id: UBERON:0008998
@@ -235366,7 +235344,7 @@ is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0001593 ! venous plexus
intersection_of: part_of UBERON:0002367 ! prostate gland
relationship: part_of UBERON:0002367 ! prostate gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/bd/Gray585.png" xsd:anyURI
[Term]
id: UBERON:0009089
@@ -235927,7 +235905,7 @@ xref: UMLS:C0004454 {source="ncithesaurus:Axilla"}
xref: Wikipedia:Axilla
is_a: UBERON:0034929 ! external soft tissue zone
relationship: part_of UBERON:0001421 {source="FMA"} ! pectoral girdle region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f2/Gray411.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f2/Gray411.png" xsd:anyURI
property_value: UBPROP:0000007 "axillary" xsd:string
[Term]
@@ -236333,6 +236311,47 @@ relationship: connects UBERON:0004302 ! proximal phalanx
relationship: part_of UBERON:0002544 ! digit
property_value: editor_note "We include these joints as being part of the digits; this is consistent with the FMA, and makes classification easier. Note that digit and metapodial regions are part-disjoint" xsd:string
+[Term]
+id: UBERON:0009564
+name: distal limb integumentary appendage
+namespace: uberon
+def: "A nail, hoof or claw." [PMID:11710767]
+synonym: "hoof or claw" RELATED []
+synonym: "hoof, claw or nail" RELATED []
+synonym: "keratin plate" RELATED []
+synonym: "keratin sheath" RELATED []
+synonym: "unguis" RELATED []
+xref: MESH:D006724
+is_a: UBERON:0013703 ! integumentary projection
+relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer
+relationship: part_of UBERON:0001003 ! skin epidermis
+relationship: part_of UBERON:0009551 {source="cjm"} ! distal segment of digit
+
+[Term]
+id: UBERON:0009565
+name: nail of manual digit
+namespace: uberon
+def: "A nail that is part of a manual digit." [OBOL:automatic]
+subset: pheno_slim
+synonym: "claw of hand" NARROW SENSU []
+synonym: "claw of manus" NARROW SENSU []
+synonym: "finger nail" EXACT [FMA:54327]
+synonym: "fingernail" EXACT [FMA:54327]
+synonym: "forelimb digit claw" NARROW SENSU [EMAPA:35349]
+synonym: "manual claw" NARROW SENSU []
+synonym: "nail of finger" EXACT [FMA:54327]
+synonym: "nail plate of finger" RELATED [FMA:54327]
+xref: EMAPA:35349
+xref: FMA:54327
+xref: NCIT:C32609
+xref: SCTID:244197001
+xref: UMLS:C0222001 {source="ncithesaurus:Fingernail"}
+is_a: UBERON:0001705 ! nail
+intersection_of: UBERON:0001705 ! nail
+intersection_of: part_of UBERON:0002389 ! manual digit
+relationship: part_of UBERON:0005276 {source="FMA"} ! dorsal skin of finger
+relationship: part_of UBERON:0009552 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! distal segment of manual digit
+
[Term]
id: UBERON:0009566
name: intestinal submucosa
@@ -236345,6 +236364,35 @@ intersection_of: UBERON:0000009 ! submucosa
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001262 {source="FMA"} ! wall of intestine
+[Term]
+id: UBERON:0009567
+name: nail of pedal digit
+namespace: uberon
+def: "A nail that is part of a pedal digit." [OBOL:automatic]
+subset: pheno_slim
+synonym: "claw of foot" NARROW SENSU []
+synonym: "claw of pes" NARROW SENSU []
+synonym: "claw of toe" NARROW SENSU []
+synonym: "hindlimb claw" NARROW SENSU [EMAPA:36457]
+synonym: "hindlimb digit claw" NARROW SENSU []
+synonym: "nail of pes" EXACT []
+synonym: "nail of toe" EXACT [FMA:54328]
+synonym: "nail plate of toe" RELATED [FMA:54328]
+synonym: "pedal claw" NARROW SENSU []
+synonym: "toe nail" EXACT [FMA:54328]
+synonym: "toenail" EXACT [FMA:54328]
+xref: EMAPA:36457
+xref: FMA:54328
+xref: NCIT:C33790
+xref: SCTID:244198006
+xref: UMLS:C0222007 {source="ncithesaurus:Toe_Nail"}
+xref: XAO:0003103
+is_a: UBERON:0001705 ! nail
+intersection_of: UBERON:0001705 ! nail
+intersection_of: part_of UBERON:0001466 ! pedal digit
+relationship: part_of UBERON:0005277 {source="FMA"} ! dorsal skin of toe
+relationship: part_of UBERON:0009553 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! distal segment of pedal digit
+
[Term]
id: UBERON:0009568
name: trunk region of vertebral column
@@ -237482,7 +237530,7 @@ intersection_of: part_of UBERON:0002530 ! gland
relationship: has_part CL:0000151 ! secretory cell
relationship: has_quality PATO:0002422 ! acinar
relationship: part_of UBERON:0002530 ! gland
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI
property_value: UBPROP:0000007 "acinar" xsd:string
[Term]
@@ -237622,7 +237670,7 @@ is_a: UBERON:0000158 ! membranous layer
relationship: adjacent_to UBERON:0002484 ! bone marrow cavity
relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue
relationship: part_of UBERON:0002495 ! long bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/94/Illu_long_bone.jpg" xsd:anyURI
property_value: UBPROP:0000007 "endosteal" xsd:string
[Term]
@@ -237644,7 +237692,7 @@ is_a: UBERON:0034944 ! zone of organ
intersection_of: UBERON:0034944 ! zone of organ
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Regions_of_stomach.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Regions_of_stomach.svg" xsd:anyURI
property_value: editor_note "We follow Kardong in defining stomach regions by gland, but we also include 'body of stomach'. In future we may want to have different partitions of the stomach" xsd:string
[Term]
@@ -237782,7 +237830,7 @@ relationship: part_of UBERON:0001442 ! skeleton of manus
relationship: part_of UBERON:0004452 ! carpal region
relationship: proximally_connected_to UBERON:0010703 ! forelimb zeugopod skeleton
relationship: skeleton_of UBERON:0004452 ! carpal region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/58/Carpus.svg" xsd:anyURI
property_value: UBPROP:0000001 "Segment of the forearm corresponding to the carpus. It consists of several elements that articulate with the radius and ulna at one end and the metacarpals at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000201", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000003 "The three main outgroup taxa of tetrapods, panderichthyids, osteolepiforms, and rhizodontids, have endoskeletal elements corresponding to the stylo- and zeugopodial elements in a tetrapod limb. In addition, there are elements that share the position and possibly the developmental derivation of the ulnare and the intermedium. From these observations, most authors have concluded that the stylo- and zeugopodial elements as well as the proximal mesopodial elements have counterparts in the fins of tetrapod ancestors, but there are no indications of wrist or ankle joints.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001161", ontology="VHOG", source="DOI:10.1002/jez.1100 Wagner GP, Chiu C, The tetrapod limb: A hypothesis on its origin. J Exp Zool (Mol Dev Evol) (2001)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "Not always associated with digits, in sarcopterygians the ulnare is present without true digits being formed, though their homologous radial elements are present[PHENOSCAPE:ad]." xsd:string {source="Wikipedia:Carpus#Evolutionary_variations"}
@@ -237816,7 +237864,7 @@ xref: Wikipedia:Anal_columns
is_a: UBERON:0034944 ! zone of organ
relationship: has_quality PATO:0001910 ! folded
relationship: part_of UBERON:0000159 ! anal canal
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI
[Term]
id: UBERON:0009883
@@ -237863,7 +237911,7 @@ intersection_of: UBERON:0001637 ! artery
intersection_of: supplies UBERON:0009913 ! renal lobe
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0009913 ! renal lobe
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
property_value: UBPROP:0000012 "FMA only has the set term" xsd:string {external_ontology="FMA"}
[Term]
@@ -237885,7 +237933,7 @@ intersection_of: drains UBERON:0009913 ! renal lobe
relationship: connected_to UBERON:0001140 ! renal vein
relationship: drains UBERON:0009913 ! renal lobe
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
property_value: UBPROP:0000012 "FMA only has the set term" xsd:string {external_ontology="FMA"}
[Term]
@@ -237982,7 +238030,7 @@ intersection_of: UBERON:0009912 ! anatomical lobe
intersection_of: part_of UBERON:0002113 ! kidney
relationship: contributes_to_morphology_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/7/7e/Kidney_PioM.png" xsd:anyURI
property_value: editor_note "todo - add has_part relationships." xsd:string
property_value: UBPROP:0000008 "human kidneys have multilobar (multipyramidal) architecture while mice and rats have unilobar (unipyramidal) kidneys" xsd:string {source="MP"}
@@ -238553,7 +238601,7 @@ intersection_of: develops_from UBERON:0006260 {source="ISBN:1607950324"} ! lingu
intersection_of: part_of UBERON:0001723 {source="ISBN:1607950324"} ! tongue
relationship: develops_from UBERON:0006260 ! lingual swellings
relationship: part_of UBERON:0001723 ! tongue
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/4/4c/Illu04_tongue.jpg" xsd:anyURI
property_value: UBPROP:0000011 "The lateral lingual swellings grow and fuse with eachother, encompassing the tuberculum impar to provide the ectodermally derived mucosa of the anterior 2/3 of the tongue" xsd:string
property_value: UBPROP:0000012 "check NCIT" xsd:string {external_ontology="NCIT"}
@@ -238580,7 +238628,7 @@ intersection_of: part_of UBERON:0001160 ! fundus of stomach
relationship: has_part CL:0000155 {source="ISBN:0073040584"} ! peptic cell
relationship: has_part CL:0000162 {source="ISBN:0073040584"} ! parietal cell
relationship: part_of UBERON:0004994 ! mucosa of fundus of stomach
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Fundic_gland_polyp_%281%29.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Fundic_gland_polyp_%281%29.jpg" xsd:anyURI
property_value: editor_note "Consider FMA:14923 ! Principal gland of fundus of stomach. Added part_of to mucosa to be consistent with FMA pattern (note that Kardong places this in the glandular epithelium)" xsd:string
[Term]
@@ -239104,7 +239152,7 @@ intersection_of: connects UBERON:0000209 ! tetrapod frontal bone
intersection_of: connects UBERON:0001677 ! sphenoid bone
relationship: connects UBERON:0000209 ! tetrapod frontal bone
relationship: connects UBERON:0001677 ! sphenoid bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray164.png" xsd:anyURI
[Term]
id: UBERON:0010160
@@ -239712,7 +239760,7 @@ xref: SCTID:263344003
xref: Wikipedia:Lacrimal_punctum
is_a: UBERON:0000161 {source="FMA"} ! orifice
relationship: part_of UBERON:0001850 ! lacrimal drainage system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray895.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/53/Gray895.png" xsd:anyURI
property_value: UBPROP:0000009 "collect tears produced by the lacrimal glands" xsd:string
[Term]
@@ -240193,7 +240241,7 @@ synonym: "ossification centre" EXACT [FMA:75436]
xref: FMA:75436
xref: Wikipedia:Ossification_center
is_a: UBERON:0005913 {source="FMA"} ! zone of bone organ
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/fd/Gray79.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/fd/Gray79.png" xsd:anyURI
property_value: editor_note "currently classified as a zone of a bone organ, but exists prior to bone ossifying" xsd:string
[Term]
@@ -240859,7 +240907,7 @@ xref: SCTID:280860001
xref: Wikipedia:Ciliary_processes
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0001775 ! ciliary body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb" xsd:string
@@ -241180,7 +241228,7 @@ disjoint_from: UBERON:0010545 {source="lexical"} ! metatarsus skeleton
relationship: develops_from UBERON:0010699 {notes="many to one"} ! manual digit metacarpus cartilage element
relationship: proximally_connected_to UBERON:0009880 ! carpal skeleton
relationship: skeleton_of UBERON:0004453 ! metacarpus region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2f/Metacarpals_numbered-en.svg" xsd:anyURI
property_value: UBPROP:0000001 "Segment of the forearm corresponding to the metacarpus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000946", ontology="AAO", source="AAO:LAP"}
[Term]
@@ -241213,7 +241261,7 @@ intersection_of: skeleton_of UBERON:0000983 ! metatarsus region
relationship: develops_from UBERON:0010697 {notes="many to one"} ! pedal digit metatarsal cartilage element
relationship: proximally_connected_to UBERON:0009879 ! tarsal skeleton
relationship: skeleton_of UBERON:0000983 ! metatarsus region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/52/Gray291.png" xsd:anyURI
property_value: UBPROP:0000001 "Segment of the leg corresponding to the metatarsus, which articulates with the carpals at one end and with the phalanges at the other end.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000221", ontology="AAO", source="AAO:LAP"}
[Term]
@@ -241801,7 +241849,7 @@ xref: UMLS:C0282491 {source="ncithesaurus:Germinal_Center"}
xref: Wikipedia:Germinal_center
is_a: UBERON:0001744 ! lymphoid tissue
relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/60/Germinal_center.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/60/Germinal_center.svg" xsd:anyURI
[Term]
id: UBERON:0010755
@@ -242548,8 +242596,8 @@ intersection_of: connects UBERON:0001447 ! tarsal bone
intersection_of: connects UBERON:0001448 ! metatarsal bone
relationship: connects UBERON:0001447 ! tarsal bone
relationship: connects UBERON:0001448 ! metatarsal bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray355.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8e/Gray355.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png" xsd:anyURI
[Term]
id: UBERON:0011119
@@ -242572,7 +242620,7 @@ intersection_of: connects UBERON:0001435 ! carpal bone
intersection_of: connects UBERON:0002374 ! metacarpal bone
relationship: connects UBERON:0001435 ! carpal bone
relationship: connects UBERON:0002374 ! metacarpal bone
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray335.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/7c/Gray335.png" xsd:anyURI
[Term]
id: UBERON:0011120
@@ -242623,7 +242671,7 @@ intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: connects UBERON:0001435 {cardinality="2"} ! carpal bone
relationship: connects UBERON:0001435 {notes="two adjacent carpals"} ! carpal bone
relationship: part_of UBERON:0004452 {source="FMA"} ! carpal region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/37/Gray336.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/37/Gray336.png" xsd:anyURI
[Term]
id: UBERON:0011133
@@ -242638,7 +242686,7 @@ intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: connects UBERON:0001448 {cardinality="2"} ! metatarsal bone
relationship: connects UBERON:0001448 {notes="two adjacent metatarsals"} ! metatarsal bone
relationship: part_of UBERON:0000983 ! metatarsus region
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/dc/Gray358.png" xsd:anyURI
property_value: UBPROP:0000008 "In humans: The base of the first metatarsal is not connected with that of the second by any ligaments; in this respect the great toe resembles the thumb" xsd:string {source="WP"}
[Term]
@@ -242795,7 +242843,7 @@ xref: Wikipedia:Facial_skeleton
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011158 {source="FMA"} ! primary subdivision of skull
relationship: part_of UBERON:0001456 {source="FMA"} ! face
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg" xsd:anyURI
[Term]
id: UBERON:0011158
@@ -242907,7 +242955,7 @@ xref: EMAPA:19313
xref: Wikipedia:Ophthalmic_veins
xref: XAO:0004169
is_a: UBERON:0009141 {source="EHDAA2-modified"} ! craniocervical region vein
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:string
@@ -242927,7 +242975,7 @@ xref: Wikipedia:Superior_ophthalmic_vein
is_a: UBERON:0011191 ! ophthalmic vein
relationship: connected_to UBERON:0003712 ! cavernous sinus
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/02/Gray572.png" xsd:anyURI
[Term]
id: UBERON:0011197
@@ -243780,7 +243828,7 @@ is_a: UBERON:0003716 ! recurrent laryngeal nerve
intersection_of: UBERON:0003716 ! recurrent laryngeal nerve
intersection_of: in_left_side_of UBERON:0000468 ! multicellular organism
relationship: in_left_side_of UBERON:0000468 ! multicellular organism
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/6/64/Recurrent_laryngeal_nerve.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/6/64/Recurrent_laryngeal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000008 "The left nerve is longer than the right, because it crosses under the arch of the aorta at the ligamentum arteriosum.[WP]" xsd:string
[Term]
@@ -246865,7 +246913,7 @@ intersection_of: UBERON:0002553 ! anatomical cavity
intersection_of: luminal_space_of UBERON:0003129 ! skull
relationship: luminal_space_of UBERON:0003129 ! skull
relationship: part_of UBERON:0003129 {source="Wikipedia"} ! skull
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
[Term]
id: UBERON:0013478
@@ -249047,7 +249095,7 @@ relationship: adjacent_to UBERON:0001981 ! blood vessel
relationship: adjacent_to UBERON:0002361 ! pia mater
relationship: location_of UBERON:0001359 ! cerebrospinal fluid
relationship: part_of UBERON:0010743 ! meningeal cluster
-property_value: depicted_by "https://static-content.springer.com/image/art%3A10.1007%2Fs11064-015-1581-6/MediaObjects/11064_2015_1581_Fig3_HTML.gif" xsd:anyURI
+property_value: depicted:by "https://static-content.springer.com/image/art%3A10.1007%2Fs11064-015-1581-6/MediaObjects/11064_2015_1581_Fig3_HTML.gif" xsd:anyURI
[Term]
id: UBERON:0014935
@@ -257945,7 +257993,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -257957,7 +258004,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -258061,10 +258108,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -258073,15 +258117,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -258126,10 +258166,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -258140,15 +258177,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -258156,34 +258190,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -258192,7 +258217,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -258362,7 +258386,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -258413,7 +258437,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -258621,7 +258645,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -258711,7 +258735,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -258968,6 +258992,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -259100,7 +259151,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -259148,7 +259199,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -259226,7 +259277,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -259469,13 +259520,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -259811,7 +259855,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -259823,9 +259866,7 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
-range: CARO:0000010 ! anatomical boundary
is_a: RO:0002323 ! mereotopologically related to
[Typedef]
@@ -259950,7 +259991,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -260141,12 +260182,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -260391,10 +260443,8 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -260402,7 +260452,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
domain: UBERON:0000122 ! neuron projection bundle
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -260445,8 +260494,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -260502,7 +260551,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -260551,7 +260599,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -260611,7 +260658,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -260685,7 +260732,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -260871,7 +260917,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -261262,10 +261307,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -261274,7 +261317,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/patterns/definitions.owl b/patterns/definitions.owl
index 05b4eb81d..35433ca3e 100644
--- a/patterns/definitions.owl
+++ b/patterns/definitions.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=)
Ontology(
-
-Annotation(owl:versionInfo "2023-09-20")
+
+Annotation(owl:versionInfo "2023-10-18")
diff --git a/src/ontology/diffs/cl-diff.md b/src/ontology/diffs/cl-diff.md
index c7326bd55..86a1a2374 100644
--- a/src/ontology/diffs/cl-diff.md
+++ b/src/ontology/diffs/cl-diff.md
@@ -2,12 +2,12 @@
## Left
- Ontology IRI: `http://purl.obolibrary.org/obo/cl.owl`
-- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-08-24/cl.owl`
+- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-09-21/cl.owl`
- Loaded from: `http://purl.obolibrary.org/obo/cl.owl`
## Right
- Ontology IRI: `http://purl.obolibrary.org/obo/cl.owl`
-- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-09-21/cl.owl`
+- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-10-19/cl.owl`
- Loaded from: `file:/work/src/ontology/../../cl.owl`
### Ontology imports
@@ -16,4894 +16,6485 @@
### Ontology annotations
#### Removed
-- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-08-24"
+- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-09-21"
#### Added
-- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-09-21"
+- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-10-19"
-### A2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004219`
+### BFO_0000009 `http://purl.obolibrary.org/obo/BFO_0000009`
#### Removed
-- [A2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004219) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- Class: [BFO_0000009](http://purl.obolibrary.org/obo/BFO_0000009)
-#### Added
-- [A2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004219) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A bistratifed retinal amacrine cell with a small dendritic field, dendrite stratification in S1-S2, and a second dendrite stratification in S5. This cell type releases the neurotransmitter glycine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24246263"
-- [A2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004219) SubClassOf [glycinergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030028)
+### Betz cell `http://purl.obolibrary.org/obo/CL_0008049`
+#### Removed
+- [Betz cell](http://purl.obolibrary.org/obo/CL_0008049) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg"
-- [A2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004219) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+#### Added
+- [Betz cell](http://purl.obolibrary.org/obo/CL_0008049) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://en.wikipedia.org/w/index.php?title=Betz_cell&oldid=977472330#/media/File:GolgiStainedPyramidalCell.jpg"
-### A2-like amacrine cell `http://purl.obolibrary.org/obo/CL_0004229`
+### CCL3-positive alveolar macrophage `http://purl.obolibrary.org/obo/CL_4033041`
#### Added
-- [A2-like amacrine cell](http://purl.obolibrary.org/obo/CL_0004229) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
-
+- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### AB broad diffuse-1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004235`
-#### Removed
-- [AB broad diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004235) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
-
-- [AB broad diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004235) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-#### Added
-- [AB broad diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004235) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+### CHEBI_15355 `http://purl.obolibrary.org/obo/CHEBI_15355`
+#### Removed
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "choline acetate"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChemIDplus:"
-- [AB broad diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004235) SubClassOf [GABAergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030027)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [InChI](http://purl.obolibrary.org/obo/fbbt#InChI)
-- [AB broad diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004235) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "InChIKey=OIPILFWXSMYKGL-UHFFFAOYSA-N"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### AB broad diffuse-2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004236`
-#### Removed
-- [AB broad diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004236) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [InChIKey](http://purl.obolibrary.org/obo/fbbt#InChIKey)
-- [AB broad diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004236) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CC(=O)OCC[N+](C)(C)C"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [AB broad diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004236) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SMILES](http://purl.obolibrary.org/obo/fbbt#SMILES)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Acetylcholine"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-- [AB broad diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004236) SubClassOf [GABAergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030027)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-- [AB broad diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004236) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "2-acetyloxy-N,N,N-trimethylethanaminium"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-### AB diffuse-1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004223`
-#### Removed
-- [AB diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004223) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Azetylcholin"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [AB diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004223) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACh"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChemIDplus:"
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:15355"
-### AB diffuse-2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004224`
-#### Removed
-- [AB diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004224) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ACETYLCHOLINE"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PDBeChem:"
-- [AB diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004224) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "C7H16NO2"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-#### Added
-- [AB diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004224) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A broadly stratifying amacrine cell that has a small dendritic field and post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [FORMULA](http://purl.obolibrary.org/obo/fbbt#FORMULA)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-- [AB diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004224) SubClassOf [glycinergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030028)
+- [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O-Acetylcholine"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-- [AB diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004224) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
-### BEST4+ intestinal epithelial cell, human `http://purl.obolibrary.org/obo/CL_4030026`
+### CHEBI_16670 `http://purl.obolibrary.org/obo/CHEBI_16670`
#### Removed
-- [BEST4+ intestinal epithelial cell, human](http://purl.obolibrary.org/obo/CL_4030026) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-#### Added
-- [BEST4+ intestinal epithelial cell, human](http://purl.obolibrary.org/obo/CL_4030026) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Peptid"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "peptidos"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### CD25+ mast cell `http://purl.obolibrary.org/obo/CL_0011023`
-#### Removed
-- [CD25+ mast cell](http://purl.obolibrary.org/obo/CL_0011023) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Peptide"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "peptido"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-### Caenorhabditis hypodermal cell `http://purl.obolibrary.org/obo/CL_0000411`
-#### Removed
-- [Caenorhabditis hypodermal cell](http://purl.obolibrary.org/obo/CL_0000411) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:16670"
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "C2H4NO2R(C2H2NOR)n"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-### DAPI-3 amacrine cell `http://purl.obolibrary.org/obo/CL_0004233`
-#### Removed
-- [DAPI-3 amacrine cell](http://purl.obolibrary.org/obo/CL_0004233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4."
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [FORMULA](http://purl.obolibrary.org/obo/fbbt#FORMULA)
-#### Added
-- [DAPI-3 amacrine cell](http://purl.obolibrary.org/obo/CL_0004233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a medium dendritic field and post-synaptic terminals that stratify at S2, with a second stratification that occurs in S3 and S4. This cell type releases the neurotransmitter glycine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9194315"
+- [CHEBI_16670](http://purl.obolibrary.org/obo/CHEBI_16670) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "peptides"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-- [DAPI-3 amacrine cell](http://purl.obolibrary.org/obo/CL_0004233) SubClassOf [glycinergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030028)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-- [DAPI-3 amacrine cell](http://purl.obolibrary.org/obo/CL_0004233) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
-### Eumycetozoan cell `http://purl.obolibrary.org/obo/CL_0000257`
+### CHEBI_18059 `http://purl.obolibrary.org/obo/CHEBI_18059`
#### Removed
-- [Eumycetozoan cell](http://purl.obolibrary.org/obo/CL_0000257) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eumycetozoa](http://purl.obolibrary.org/obo/NCBITaxon_142796))
+- [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lipids"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-#### Added
-- [Eumycetozoan cell](http://purl.obolibrary.org/obo/CL_0000257) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eumycetozoa](http://purl.obolibrary.org/obo/NCBITaxon_142796))
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
+- [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Lipid"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-### His-Purkinje system cell `http://purl.obolibrary.org/obo/CL_0010007`
-#### Removed
-- [His-Purkinje system cell](http://purl.obolibrary.org/obo/CL_0010007) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [His-Purkinje system](http://purl.obolibrary.org/obo/UBERON_0004146))
+- [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:18059"
-- [His-Purkinje system cell](http://purl.obolibrary.org/obo/CL_0010007) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [His-Purkinje system cell](http://purl.obolibrary.org/obo/CL_0010007) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [His-Purkinje system](http://purl.obolibrary.org/obo/UBERON_0004146))
+- [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-- [His-Purkinje system cell](http://purl.obolibrary.org/obo/CL_0010007) SubClassOf [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494)
+- [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lipid"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProt:"
-### IAO_0000234 `http://purl.obolibrary.org/obo/IAO_0000234`
-#### Added
-- AnnotationProperty: [IAO_0000234](http://purl.obolibrary.org/obo/IAO_0000234)
+### CHEBI_24431 `http://purl.obolibrary.org/obo/CHEBI_24431`
+#### Removed
+- [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:24431"
+- [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### L2/3 bipolar vip GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023007`
-#### Removed
-- [L2/3 bipolar vip GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023007) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3 bipolar vip GABAergic cortical interneuron (Mmus)"
+- [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [L2/3 bipolar vip GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023007) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3 bipolar vip GABAergic interneuron (Mmus)"
-### L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023047`
+### CHEBI_24780 `http://purl.obolibrary.org/obo/CHEBI_24780`
#### Removed
-- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1101/2020.10.19.343129"
-
-#### Added
-- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3 of the primary motor cortex."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1101/2020.10.19.343129"
+- [CHEBI_24780](http://purl.obolibrary.org/obo/CHEBI_24780) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:24780"
+- [CHEBI_24780](http://purl.obolibrary.org/obo/CHEBI_24780) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### L2/3-6 intratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023040`
-#### Removed
-- [L2/3-6 intratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023040) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3-6 intratelencephalic projecting glutamatergic cortical neuron"
+- [CHEBI_24780](http://purl.obolibrary.org/obo/CHEBI_24780) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [L2/3-6 intratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023040) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3-6 intratelencephalic projecting glutamatergic neuron"
-### L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023030`
+### CHEBI_24828 `http://purl.obolibrary.org/obo/CHEBI_24828`
#### Removed
-- [L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023030) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus)"
-
-#### Added
-- [L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023030) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3/5 fan Martinotti sst GABAergic interneuron (Mmus)"
+- [CHEBI_24828](http://purl.obolibrary.org/obo/CHEBI_24828) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:24828"
+- [CHEBI_24828](http://purl.obolibrary.org/obo/CHEBI_24828) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### L4 sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023031`
-#### Removed
-- [L4 sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023031) [label](http://www.w3.org/2000/01/rdf-schema#label) "L4 sst GABAergic cortical interneuron (Mmus)"
+- [CHEBI_24828](http://purl.obolibrary.org/obo/CHEBI_24828) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any compound containing an indole skeleton."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [L4 sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023031) [label](http://www.w3.org/2000/01/rdf-schema#label) "L4 sst Martinotti interneuron (Mmus)"
-### L5 T-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023027`
+### CHEBI_25806 `http://purl.obolibrary.org/obo/CHEBI_25806`
#### Removed
-- [L5 T-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023027) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 T-Martinotti sst GABAergic cortical interneuron (Mmus)"
+- [CHEBI_25806](http://purl.obolibrary.org/obo/CHEBI_25806) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "oxygen molecular entities"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [L5 T-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023027) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 sst T-Martinotti interneuron (Mmus)"
+- [CHEBI_25806](http://purl.obolibrary.org/obo/CHEBI_25806) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:25806"
+- [CHEBI_25806](http://purl.obolibrary.org/obo/CHEBI_25806) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "oxygen molecular entity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### L5 non-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023028`
-#### Removed
-- [L5 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023028) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 non-Martinotti sst GABAergic cortical interneuron (Mmus)"
+- [CHEBI_25806](http://purl.obolibrary.org/obo/CHEBI_25806) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-#### Added
-- [L5 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023028) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 non-Martinotti sst GABAergic interneuron (Mmus)"
-### L5 vip cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023014`
+### CHEBI_32952 `http://purl.obolibrary.org/obo/CHEBI_32952`
#### Removed
-- [L5 vip cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023014) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 vip cortical GABAergic interneuron (Mmus)"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:32952"
-#### Added
-- [L5 vip cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023014) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 vip GABAergic interneuron (Mmus)"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "amines"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-### L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023023`
-#### Removed
-- [L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023023) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus)"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023023) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5,6 neurogliaform lamp5 GABAergic interneuron (Mmus)"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Amine"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### L5/6 cck cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023071`
-#### Removed
-- [L5/6 cck cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023071) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5/6 cck cortical GABAergic interneuron (Mmus)"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Amin"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [L5/6 cck cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023071) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5/6 cck GABAergic interneuron (Mmus)"
+- [CHEBI_32952](http://purl.obolibrary.org/obo/CHEBI_32952) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "an amine"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProt:"
-### L5/6 cck, vip cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023019`
-#### Removed
-- [L5/6 cck, vip cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023019) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5/6 cck, vip cortical GABAergic interneuron (Mmus)"
-#### Added
-- [L5/6 cck, vip cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023019) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5/6 cck, vip GABAergic interneuron (Mmus)"
+### CHEBI_32988 `http://purl.obolibrary.org/obo/CHEBI_32988`
+#### Removed
+- [CHEBI_32988](http://purl.obolibrary.org/obo/CHEBI_32988) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:32988"
+- [CHEBI_32988](http://purl.obolibrary.org/obo/CHEBI_32988) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-### L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023118`
-#### Removed
-- [L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023118) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus)"
+- [CHEBI_32988](http://purl.obolibrary.org/obo/CHEBI_32988) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Amide"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-#### Added
-- [L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023118) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5/6 non-Martinotti sst GABAergic interneuron (Mmus)"
+- [CHEBI_32988](http://purl.obolibrary.org/obo/CHEBI_32988) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
+- [CHEBI_32988](http://purl.obolibrary.org/obo/CHEBI_32988) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "amides"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-### L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023075`
-#### Removed
-- [L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023075) [label](http://www.w3.org/2000/01/rdf-schema#label) "L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus)"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-#### Added
-- [L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023075) [label](http://www.w3.org/2000/01/rdf-schema#label) "L6 th sst GABAergic interneuron (Mmus)"
-### L6b subplate glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023046`
+### CHEBI_33566 `http://purl.obolibrary.org/obo/CHEBI_33566`
#### Removed
-- [L6b subplate glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023046) [label](http://www.w3.org/2000/01/rdf-schema#label) "L6b subplate glutamatergic neuron of the primary motor cortex"
+- [CHEBI_33566](http://purl.obolibrary.org/obo/CHEBI_33566) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33566"
-#### Added
-- [L6b subplate glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023046) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "L6b subplate glutamatergic neuron of the primary motor cortex"
+- [CHEBI_33566](http://purl.obolibrary.org/obo/CHEBI_33566) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-- [L6b subplate glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023046) [label](http://www.w3.org/2000/01/rdf-schema#label) "L6b glutamatergic neuron of the primary motor cortex"
-### Leydig cell `http://purl.obolibrary.org/obo/CL_0000178`
+### CHEBI_33567 `http://purl.obolibrary.org/obo/CHEBI_33567`
#### Removed
-- [Leydig cell](http://purl.obolibrary.org/obo/CL_0000178) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Catecholamine"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-### Malpighian tubule stellate cell `http://purl.obolibrary.org/obo/CL_1000155`
-#### Removed
-- [Malpighian tubule stellate cell](http://purl.obolibrary.org/obo/CL_1000155) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "catecholamines"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "C8H9NO2R2"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-### WF1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004240`
-#### Removed
-- [WF1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004240) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [FORMULA](http://purl.obolibrary.org/obo/fbbt#FORMULA)
-#### Added
-- [WF1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004240) SubClassOf [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253)
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33567"
+- [CHEBI_33567](http://purl.obolibrary.org/obo/CHEBI_33567) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "catecholamines"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-### WF2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004241`
-#### Removed
-- [WF2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004241) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-#### Added
-- [WF2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004241) SubClassOf [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253)
-### WF3-1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004242`
+### CHEBI_33655 `http://purl.obolibrary.org/obo/CHEBI_33655`
#### Removed
-- [WF3-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004242) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [WF3-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004242) SubClassOf [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253)
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "aromatische Verbindungen"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "aromatic compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-### WF3-2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004243`
-#### Removed
-- [WF3-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004243) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-#### Added
-- [WF3-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004243) SubClassOf [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253)
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33655"
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "aromatics"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### WF4 amacrine cell `http://purl.obolibrary.org/obo/CL_0004244`
-#### Removed
-- [WF4 amacrine cell](http://purl.obolibrary.org/obo/CL_0004244) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "aromatic molecular entity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-#### Added
-- [WF4 amacrine cell](http://purl.obolibrary.org/obo/CL_0004244) SubClassOf [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
+- [CHEBI_33655](http://purl.obolibrary.org/obo/CHEBI_33655) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### absorptive cell `http://purl.obolibrary.org/obo/CL_0000212`
-#### Removed
-- [absorptive cell](http://purl.obolibrary.org/obo/CL_0000212) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
-#### Added
-- [absorptive cell](http://purl.obolibrary.org/obo/CL_0000212) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+### CHEBI_33709 `http://purl.obolibrary.org/obo/CHEBI_33709`
+#### Removed
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "amino acids"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### adepithelial cell `http://purl.obolibrary.org/obo/CL_0000462`
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Aminocarbonsaeure"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [adepithelial cell](http://purl.obolibrary.org/obo/CL_0000462) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Aminokarbonsaeure"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### airway submucosal gland duct ciliated cell `http://purl.obolibrary.org/obo/CL_4033055`
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Aminosaeure"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell that is part of a ciliated duct of an airway submucosal gland."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30864819"
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A carboxylic acid containing one or more amino groups."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17707699"
+- [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33709"
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [date](http://purl.org/dc/terms/date) "2023-09-08T10:32:27Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+### CHEBI_33822 `http://purl.obolibrary.org/obo/CHEBI_33822`
+#### Removed
+- [CHEBI_33822](http://purl.obolibrary.org/obo/CHEBI_33822) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [label](http://www.w3.org/2000/01/rdf-schema#label) "airway submucosal gland duct ciliated cell"
+- [CHEBI_33822](http://purl.obolibrary.org/obo/CHEBI_33822) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An organic compound having at least one hydroxy group attached to a carbon atom."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-- Class: [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055)
+- [CHEBI_33822](http://purl.obolibrary.org/obo/CHEBI_33822) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "hydroxy compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) EquivalentTo [ciliated cell](http://purl.obolibrary.org/obo/CL_0000064) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [airway submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410077)) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014))
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014)
+- [CHEBI_33822](http://purl.obolibrary.org/obo/CHEBI_33822) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33822"
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) SubClassOf [ciliated cell](http://purl.obolibrary.org/obo/CL_0000064)
+- [CHEBI_33822](http://purl.obolibrary.org/obo/CHEBI_33822) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organic hydroxy compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [airway submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410077)
-### alarm substance cell `http://purl.obolibrary.org/obo/CL_0007021`
+### CHEBI_33832 `http://purl.obolibrary.org/obo/CHEBI_33832`
#### Removed
-- [alarm substance cell](http://purl.obolibrary.org/obo/CL_0007021) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
+- [CHEBI_33832](http://purl.obolibrary.org/obo/CHEBI_33832) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33832"
+- [CHEBI_33832](http://purl.obolibrary.org/obo/CHEBI_33832) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### amacrine cell `http://purl.obolibrary.org/obo/CL_0000561`
-#### Removed
-- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [CHEBI_33832](http://purl.obolibrary.org/obo/CHEBI_33832) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organic cyclic compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-#### Added
-- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### CHEBI_33853 `http://purl.obolibrary.org/obo/CHEBI_33853`
+#### Removed
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "arenols"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "aryl alcohol"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProt:"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Aryl alcohol"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Compounds having one or more hydroxy groups attached to a benzene or other arene ring."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-### amnion `http://purl.obolibrary.org/obo/UBERON_0000305`
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-#### Added
-- [amnion](http://purl.obolibrary.org/obo/UBERON_0000305) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb"
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "phenols"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-### amoeboid cell `http://purl.obolibrary.org/obo/CL_0000732`
-#### Removed
-- [amoeboid cell](http://purl.obolibrary.org/obo/CL_0000732) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [CHEBI_33853](http://purl.obolibrary.org/obo/CHEBI_33853) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:33853"
-### animal cell `http://purl.obolibrary.org/obo/CL_0000548`
+### CHEBI_35352 `http://purl.obolibrary.org/obo/CHEBI_35352`
#### Removed
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [label](http://www.w3.org/2000/01/rdf-schema#label) "animal cell"
-
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A native cell that is part of some Metazoa."
+- [CHEBI_35352](http://purl.obolibrary.org/obo/CHEBI_35352) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any heteroorganic entity containing at least one carbon-nitrogen bond."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208))
+- [CHEBI_35352](http://purl.obolibrary.org/obo/CHEBI_35352) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "organonitrogen compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [CHEBI_35352](http://purl.obolibrary.org/obo/CHEBI_35352) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organonitrogens"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete animal cell"
+- [CHEBI_35352](http://purl.obolibrary.org/obo/CHEBI_35352) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "OBSOLETE. A native cell that is part of some Metazoa."
+- [CHEBI_35352](http://purl.obolibrary.org/obo/CHEBI_35352) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:35352"
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [cell](http://purl.obolibrary.org/obo/CL_0000000)
-- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "https://github.com/obophenotype/cell-ontology/issues/2124"
+### CHEBI_50047 `http://purl.obolibrary.org/obo/CHEBI_50047`
+#### Removed
+- [CHEBI_50047](http://purl.obolibrary.org/obo/CHEBI_50047) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
+- [CHEBI_50047](http://purl.obolibrary.org/obo/CHEBI_50047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-### animal zygote `http://purl.obolibrary.org/obo/CL_0000365`
+- [CHEBI_50047](http://purl.obolibrary.org/obo/CHEBI_50047) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:50047"
-#### Added
-- [animal zygote](http://purl.obolibrary.org/obo/CL_0000365) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [CHEBI_50047](http://purl.obolibrary.org/obo/CHEBI_50047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organic amino compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-- [animal zygote](http://purl.obolibrary.org/obo/CL_0000365) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208)
-### anucleate cell `http://purl.obolibrary.org/obo/CL_0000225`
+### CHEBI_50860 `http://purl.obolibrary.org/obo/CHEBI_50860`
#### Removed
-- [anucleate cell](http://purl.obolibrary.org/obo/CL_0000225) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [anucleate](http://purl.obolibrary.org/obo/PATO_0001405))
-
-- [anucleate cell](http://purl.obolibrary.org/obo/CL_0000225) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [CHEBI_50860](http://purl.obolibrary.org/obo/CHEBI_50860) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organic molecular entities"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [anucleate cell](http://purl.obolibrary.org/obo/CL_0000225) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [anucleate](http://purl.obolibrary.org/obo/PATO_0001405))
+- [CHEBI_50860](http://purl.obolibrary.org/obo/CHEBI_50860) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any molecular entity that contains carbon."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-- [anucleate cell](http://purl.obolibrary.org/obo/CL_0000225) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [CHEBI_50860](http://purl.obolibrary.org/obo/CHEBI_50860) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:50860"
+- [CHEBI_50860](http://purl.obolibrary.org/obo/CHEBI_50860) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organic compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### aorta `http://purl.obolibrary.org/obo/UBERON_0000947`
+- [CHEBI_50860](http://purl.obolibrary.org/obo/CHEBI_50860) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "organic entity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [aorta](http://purl.obolibrary.org/obo/UBERON_0000947) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [CHEBI_50860](http://purl.obolibrary.org/obo/CHEBI_50860) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-- [aorta](http://purl.obolibrary.org/obo/UBERON_0000947) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-### apoptosis fated cell `http://purl.obolibrary.org/obo/CL_0000445`
+### CHEBI_50906 `http://purl.obolibrary.org/obo/CHEBI_50906`
#### Removed
-- [apoptosis fated cell](http://purl.obolibrary.org/obo/CL_0000445) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- Class: [CHEBI_50906](http://purl.obolibrary.org/obo/CHEBI_50906)
-#### Added
-- [apoptosis fated cell](http://purl.obolibrary.org/obo/CL_0000445) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [CHEBI_50906](http://purl.obolibrary.org/obo/CHEBI_50906) SubClassOf [role](http://purl.obolibrary.org/obo/BFO_0000023)
-### arcade cell `http://purl.obolibrary.org/obo/CL_0000418`
-#### Removed
-- [arcade cell](http://purl.obolibrary.org/obo/CL_0000418) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### CHEBI_50994 `http://purl.obolibrary.org/obo/CHEBI_50994`
+#### Removed
+- [CHEBI_50994](http://purl.obolibrary.org/obo/CHEBI_50994) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:50994"
+- [CHEBI_50994](http://purl.obolibrary.org/obo/CHEBI_50994) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### arch of aorta `http://purl.obolibrary.org/obo/UBERON_0001508`
+- [CHEBI_50994](http://purl.obolibrary.org/obo/CHEBI_50994) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
-#### Added
-- [arch of aorta](http://purl.obolibrary.org/obo/UBERON_0001508) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [CHEBI_50994](http://purl.obolibrary.org/obo/CHEBI_50994) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "primary amino compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-- [arch of aorta](http://purl.obolibrary.org/obo/UBERON_0001508) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-### ascending aorta `http://purl.obolibrary.org/obo/UBERON_0001496`
+### CHEBI_51143 `http://purl.obolibrary.org/obo/CHEBI_51143`
+#### Removed
+- [CHEBI_51143](http://purl.obolibrary.org/obo/CHEBI_51143) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Nitrogenous compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-#### Added
-- [ascending aorta](http://purl.obolibrary.org/obo/UBERON_0001496) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [CHEBI_51143](http://purl.obolibrary.org/obo/CHEBI_51143) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nitrogen compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-- [ascending aorta](http://purl.obolibrary.org/obo/UBERON_0001496) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [CHEBI_51143](http://purl.obolibrary.org/obo/CHEBI_51143) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:51143"
+- [CHEBI_51143](http://purl.obolibrary.org/obo/CHEBI_51143) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-### ascending colon `http://purl.obolibrary.org/obo/UBERON_0001156`
+- [CHEBI_51143](http://purl.obolibrary.org/obo/CHEBI_51143) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nitrogen molecular entities"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [ascending colon](http://purl.obolibrary.org/obo/UBERON_0001156) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
-- [ascending colon](http://purl.obolibrary.org/obo/UBERON_0001156) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+### CHEBI_5686 `http://purl.obolibrary.org/obo/CHEBI_5686`
+#### Removed
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "compuesto heterociclico"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-### asymmetric bistratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004238`
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "chebi_ontology"
-#### Added
-- [asymmetric bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004238) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cyclic compound having as ring members atoms of at least two different elements."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ANON:ANON"
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "compuestos heterociclicos"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPAC:"
-### atrioventricular bundle cell `http://purl.obolibrary.org/obo/CL_0010005`
-#### Removed
-- [atrioventricular bundle cell](http://purl.obolibrary.org/obo/CL_0010005) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bundle of His](http://purl.obolibrary.org/obo/UBERON_0002353))
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "heterocyclic compounds"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-#### Added
-- [atrioventricular bundle cell](http://purl.obolibrary.org/obo/CL_0010005) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bundle of His](http://purl.obolibrary.org/obo/UBERON_0002353))
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [id](http://www.geneontology.org/formats/oboInOwl#id) "CHEBI:5686"
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "heterocycle"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ChEBI:"
-### barrier cell `http://purl.obolibrary.org/obo/CL_0000215`
-#### Removed
-- [barrier cell](http://purl.obolibrary.org/obo/CL_0000215) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Heterocyclic compound"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "KEGG COMPOUND:"
-#### Added
-- [barrier cell](http://purl.obolibrary.org/obo/CL_0000215) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### barrier epithelial cell `http://purl.obolibrary.org/obo/CL_0000073`
+### D1/D2-hybrid medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030050`
#### Removed
-- [barrier epithelial cell](http://purl.obolibrary.org/obo/CL_0000073) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/2"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hybrid D1/2 cell type"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### binucleate cell `http://purl.obolibrary.org/obo/CL_0000227`
-#### Removed
-- [binucleate cell](http://purl.obolibrary.org/obo/CL_0000227) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [binucleate](http://purl.obolibrary.org/obo/PATO_0001406))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-#### Added
-- [binucleate cell](http://purl.obolibrary.org/obo/CL_0000227) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [binucleate](http://purl.obolibrary.org/obo/PATO_0001406))
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2 hybrid"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### bladder cell `http://purl.obolibrary.org/obo/CL_1001319`
-#### Removed
-- [bladder cell](http://purl.obolibrary.org/obo/CL_1001319) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001255))
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2-hybrid MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-#### Added
-- [bladder cell](http://purl.obolibrary.org/obo/CL_1001319) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001255))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+#### Added
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2 hybrid"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### blood vasculature `http://purl.obolibrary.org/obo/UBERON_0004537`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [blood vasculature](http://purl.obolibrary.org/obo/UBERON_0004537) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/2"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [blood vasculature](http://purl.obolibrary.org/obo/UBERON_0004537) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2-hybrid MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### blood vessel `http://purl.obolibrary.org/obo/UBERON_0001981`
-#### Removed
-- [blood vessel](http://purl.obolibrary.org/obo/UBERON_0001981) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [blood vessel](http://purl.obolibrary.org/obo/UBERON_0001981) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hybrid D1/2 cell type"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### bone cell `http://purl.obolibrary.org/obo/CL_0001035`
+### FORMULA `http://purl.obolibrary.org/obo/fbbt#FORMULA`
#### Removed
-- [bone cell](http://purl.obolibrary.org/obo/CL_0001035) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bone element](http://purl.obolibrary.org/obo/UBERON_0001474))
-
-- [bone cell](http://purl.obolibrary.org/obo/CL_0001035) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- AnnotationProperty: [FORMULA](http://purl.obolibrary.org/obo/fbbt#FORMULA)
-#### Added
-- [bone cell](http://purl.obolibrary.org/obo/CL_0001035) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bone element](http://purl.obolibrary.org/obo/UBERON_0001474))
+- [FORMULA](http://purl.obolibrary.org/obo/fbbt#FORMULA) SubPropertyOf: [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty)
-- [bone cell](http://purl.obolibrary.org/obo/CL_0001035) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### brachiocephalic artery `http://purl.obolibrary.org/obo/UBERON_0001529`
+### Feyrter cell `http://purl.obolibrary.org/obo/CL_0002066`
+#### Removed
+- [Feyrter cell](http://purl.obolibrary.org/obo/CL_0002066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "P cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [brachiocephalic artery](http://purl.obolibrary.org/obo/UBERON_0001529) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-
-- [brachiocephalic artery](http://purl.obolibrary.org/obo/UBERON_0001529) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [Feyrter cell](http://purl.obolibrary.org/obo/CL_0002066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "P cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### brain `http://purl.obolibrary.org/obo/UBERON_0000955`
+### GCIs
+#### Removed
+- [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) DisjointWith [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [disconnected](http://purl.obolibrary.org/obo/PATO_0010001)
-#### Added
-- [brain](http://purl.obolibrary.org/obo/UBERON_0000955) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [has part](http://purl.obolibrary.org/obo/BFO_0000051) some ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mass](http://purl.obolibrary.org/obo/PATO_0000125)) EquivalentTo [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mass](http://purl.obolibrary.org/obo/PATO_0000125)
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Should belong in BFO, but lives in caro for now."
-- [brain](http://purl.obolibrary.org/obo/UBERON_0000955) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
-### brain vascular cell `http://purl.obolibrary.org/obo/CL_4023072`
+### H1 horizontal cell `http://purl.obolibrary.org/obo/CL_0004217`
#### Removed
-- [brain vascular cell](http://purl.obolibrary.org/obo/CL_4023072) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [vasculature of brain](http://purl.obolibrary.org/obo/UBERON_0008998))
+- [H1 horizontal cell](http://purl.obolibrary.org/obo/CL_0004217) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [brain vascular cell](http://purl.obolibrary.org/obo/CL_4023072) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
#### Added
-- [brain vascular cell](http://purl.obolibrary.org/obo/CL_4023072) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [vasculature of brain](http://purl.obolibrary.org/obo/UBERON_0008998))
+- [H1 horizontal cell](http://purl.obolibrary.org/obo/CL_0004217) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [brain vascular cell](http://purl.obolibrary.org/obo/CL_4023072) SubClassOf [neural cell](http://purl.obolibrary.org/obo/CL_0002319)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### broad diffuse amacrine cell `http://purl.obolibrary.org/obo/CL_0004228`
+### H2 horizontal cell `http://purl.obolibrary.org/obo/CL_0004218`
#### Removed
-- [broad diffuse amacrine cell](http://purl.obolibrary.org/obo/CL_0004228) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
-
-#### Added
-- [broad diffuse amacrine cell](http://purl.obolibrary.org/obo/CL_0004228) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
-
+- [H2 horizontal cell](http://purl.obolibrary.org/obo/CL_0004218) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H2"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### bronchial submucosal gland ciliated duct `http://purl.obolibrary.org/obo/UBERON_8600010`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
#### Added
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [label](http://www.w3.org/2000/01/rdf-schema#label) "bronchial submucosal gland ciliated duct"
+- [H2 horizontal cell](http://purl.obolibrary.org/obo/CL_0004218) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H2"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
-
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [date](http://purl.org/dc/terms/date) "2023-05-02T08:07:56Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8600010"
+### Hofbauer cell `http://purl.obolibrary.org/obo/CL_3000001`
+#### Removed
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Oval eosinophilic histiocytes with granules and vacuoles found in placenta, which are of mesenchymal origin, in mesoderm of the chorionic villus, particularly numerous in early pregnancy."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30429548"
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated duct part of a bronchial submucosal gland."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30864819"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:CellBLAST"
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) SubClassOf [macrophage](http://purl.obolibrary.org/obo/CL_0000235)
-- Class: [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010)
+#### Added
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A tissue-resident macrophage that is part of the placenta. A Hofbauer cell expresses high levels of growth factors and metalloproteinases that support vasculogenesis, angiogenesis, branching morphogenesis and tissue remodeling. A Hofbauer cell has a fetal origin and is present throughout pregnancy."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35438172"
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) EquivalentTo [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bronchus submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410043))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30429548"
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) SubClassOf [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:CellBLAST"
-- [bronchial submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600010) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bronchus submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410043)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30498493"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34745147"
-### bronchus `http://purl.obolibrary.org/obo/UBERON_0002185`
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-#### Added
-- [bronchus](http://purl.obolibrary.org/obo/UBERON_0002185) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HBC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [bronchus](http://purl.obolibrary.org/obo/UBERON_0002185) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Hofbauer cells are a heterogenic group of macrophages that resemble M2-like cells. Initially described in chorionic villi in humans, a Hofbauer cell is now often used to describe any fetal-derived placental macrophage that resides within the placental villous core, amnion, and chorion laeve."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30498493"
-- [bronchus](http://purl.obolibrary.org/obo/UBERON_0002185) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) SubClassOf [tissue-resident macrophage](http://purl.obolibrary.org/obo/CL_0000864)
-- [bronchus](http://purl.obolibrary.org/obo/UBERON_0002185) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+- [Hofbauer cell](http://purl.obolibrary.org/obo/CL_3000001) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [placenta](http://purl.obolibrary.org/obo/UBERON_0001987)
-### bronchus connective tissue `http://purl.obolibrary.org/obo/UBERON_0003592`
+### IAO_creation_date `http://purl.obolibrary.org/obo/IAO_creation_date`
#### Removed
-- [bronchus connective tissue](http://purl.obolibrary.org/obo/UBERON_0003592) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-
-- [bronchus connective tissue](http://purl.obolibrary.org/obo/UBERON_0003592) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- AnnotationProperty: [IAO_creation_date](http://purl.obolibrary.org/obo/IAO_creation_date)
-### caecum `http://purl.obolibrary.org/obo/UBERON_0001153`
-
-#### Added
-- [caecum](http://purl.obolibrary.org/obo/UBERON_0001153) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
-
-- [caecum](http://purl.obolibrary.org/obo/UBERON_0001153) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
-
-
-### cap cell `http://purl.obolibrary.org/obo/CL_0000676`
+### IAO_scope `http://purl.obolibrary.org/obo/IAO_scope`
#### Removed
-- [cap cell](http://purl.obolibrary.org/obo/CL_0000676) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- AnnotationProperty: [IAO_scope](http://purl.obolibrary.org/obo/IAO_scope)
-### capsule of liver `http://purl.obolibrary.org/obo/UBERON_0016479`
+### IUPAC_NAME `http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME`
+#### Removed
+- AnnotationProperty: [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME)
-#### Added
-- [capsule of liver](http://purl.obolibrary.org/obo/UBERON_0016479) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb"
+- [IUPAC_NAME](http://purl.obolibrary.org/obo/fbbt#IUPAC_NAME) SubPropertyOf: [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty)
-- [capsule of liver](http://purl.obolibrary.org/obo/UBERON_0016479) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb"
-### capsule of lymph node `http://purl.obolibrary.org/obo/UBERON_0002194`
+### InChI `http://purl.obolibrary.org/obo/fbbt#InChI`
+#### Removed
+- AnnotationProperty: [InChI](http://purl.obolibrary.org/obo/fbbt#InChI)
-#### Added
-- [capsule of lymph node](http://purl.obolibrary.org/obo/UBERON_0002194) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [InChI](http://purl.obolibrary.org/obo/fbbt#InChI) SubPropertyOf: [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty)
-- [capsule of lymph node](http://purl.obolibrary.org/obo/UBERON_0002194) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
-### cardiac septum cell `http://purl.obolibrary.org/obo/CL_2000022`
+### InChIKey `http://purl.obolibrary.org/obo/fbbt#InChIKey`
#### Removed
-- [cardiac septum cell](http://purl.obolibrary.org/obo/CL_2000022) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cardiac septum](http://purl.obolibrary.org/obo/UBERON_0002099))
-
-- [cardiac septum cell](http://purl.obolibrary.org/obo/CL_2000022) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- AnnotationProperty: [InChIKey](http://purl.obolibrary.org/obo/fbbt#InChIKey)
-#### Added
-- [cardiac septum cell](http://purl.obolibrary.org/obo/CL_2000022) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cardiac septum](http://purl.obolibrary.org/obo/UBERON_0002099))
+- [InChIKey](http://purl.obolibrary.org/obo/fbbt#InChIKey) SubPropertyOf: [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty)
-- [cardiac septum cell](http://purl.obolibrary.org/obo/CL_2000022) SubClassOf [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494)
-### cardiac valve cell `http://purl.obolibrary.org/obo/CL_1000147`
+### Island of Calleja granule cell `http://purl.obolibrary.org/obo/CL_4030053`
#### Removed
-- [cardiac valve cell](http://purl.obolibrary.org/obo/CL_1000147) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cardiac valve](http://purl.obolibrary.org/obo/UBERON_0000946))
+- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-ICj"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [cardiac valve cell](http://purl.obolibrary.org/obo/CL_1000147) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
#### Added
-- [cardiac valve cell](http://purl.obolibrary.org/obo/CL_1000147) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cardiac valve](http://purl.obolibrary.org/obo/UBERON_0000946))
+- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-ICj"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [cardiac valve cell](http://purl.obolibrary.org/obo/CL_1000147) SubClassOf [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### cardiac vein `http://purl.obolibrary.org/obo/UBERON_0004148`
+### L2 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030060`
#### Added
-- [cardiac vein](http://purl.obolibrary.org/obo/UBERON_0004148) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
-- [cardiac vein](http://purl.obolibrary.org/obo/UBERON_0004148) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2 intratelencephalic projecting glutamatergic neuron"
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
-### cardioblast (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000465`
-
-#### Added
-- [cardioblast (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000465) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L2 IT"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
-### cardiocyte `http://purl.obolibrary.org/obo/CL_0002494`
-#### Removed
-- [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494) EquivalentTo [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [primary circulatory organ](http://purl.obolibrary.org/obo/UBERON_0007100))
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) [date](http://purl.org/dc/terms/date) "2023-10-10T14:10:36Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- Class: [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060)
-#### Added
-- [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [primary circulatory organ](http://purl.obolibrary.org/obo/UBERON_0007100))
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer II](http://purl.obolibrary.org/obo/UBERON_0005391))
-- [cardiocyte](http://purl.obolibrary.org/obo/CL_0002494) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
+- [L2 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030060) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer II](http://purl.obolibrary.org/obo/UBERON_0005391)
-### cell of skeletal muscle `http://purl.obolibrary.org/obo/CL_0000188`
-#### Removed
-- [cell of skeletal muscle](http://purl.obolibrary.org/obo/CL_0000188) EquivalentTo [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [skeletal muscle tissue](http://purl.obolibrary.org/obo/UBERON_0001134))
-- [cell of skeletal muscle](http://purl.obolibrary.org/obo/CL_0000188) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### L2/3 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030059`
#### Added
-- [cell of skeletal muscle](http://purl.obolibrary.org/obo/CL_0000188) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [skeletal muscle tissue](http://purl.obolibrary.org/obo/UBERON_0001134))
-
-- [cell of skeletal muscle](http://purl.obolibrary.org/obo/CL_0000188) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) [date](http://purl.org/dc/terms/date) "2023-10-10T14:10:21Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-### chorionic plate `http://purl.obolibrary.org/obo/UBERON_0004027`
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
-#### Added
-- [chorionic plate](http://purl.obolibrary.org/obo/UBERON_0004027) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L2/3 IT"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### choroidal cell of the eye `http://purl.obolibrary.org/obo/CL_0000348`
-#### Removed
-- [choroidal cell of the eye](http://purl.obolibrary.org/obo/CL_0000348) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) [label](http://www.w3.org/2000/01/rdf-schema#label) "L2/3 intratelencephalic projecting glutamatergic neuron"
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
-### ciliary processes `http://purl.obolibrary.org/obo/UBERON_0010427`
+- Class: [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059)
-#### Added
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-l.glb"
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer II/III](http://purl.obolibrary.org/obo/UBERON_8440000))
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-r.glb"
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-r.glb"
+- [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer II/III](http://purl.obolibrary.org/obo/UBERON_8440000)
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb"
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb"
+### L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023047`
+#### Removed
+- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384)) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer II/III](http://purl.obolibrary.org/obo/UBERON_8440000))
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_R.glb"
+- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer II/III](http://purl.obolibrary.org/obo/UBERON_8440000)
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb"
+- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-- [ciliary processes](http://purl.obolibrary.org/obo/UBERON_0010427) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-l.glb"
+#### Added
+- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) EquivalentTo [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384))
+- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) SubClassOf [L2/3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030059)
-### ciliated cell `http://purl.obolibrary.org/obo/CL_0000064`
-#### Removed
-- [ciliated cell](http://purl.obolibrary.org/obo/CL_0000064) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cilium](http://purl.obolibrary.org/obo/GO_0005929))
-- [ciliated cell](http://purl.obolibrary.org/obo/CL_0000064) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### L3 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030061`
#### Added
-- [ciliated cell](http://purl.obolibrary.org/obo/CL_0000064) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cilium](http://purl.obolibrary.org/obo/GO_0005929))
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) [label](http://www.w3.org/2000/01/rdf-schema#label) "L3 intratelencephalic projecting glutamatergic neuron"
-- [ciliated cell](http://purl.obolibrary.org/obo/CL_0000064) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L3 IT"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### circulating cell `http://purl.obolibrary.org/obo/CL_0000080`
-#### Removed
-- [circulating cell](http://purl.obolibrary.org/obo/CL_0000080) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [haemolymphatic fluid](http://purl.obolibrary.org/obo/UBERON_0000179))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
-- [circulating cell](http://purl.obolibrary.org/obo/CL_0000080) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 3."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
-#### Added
-- [circulating cell](http://purl.obolibrary.org/obo/CL_0000080) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [haemolymphatic fluid](http://purl.obolibrary.org/obo/UBERON_0000179))
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) [date](http://purl.org/dc/terms/date) "2023-10-10T14:10:47Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [circulating cell](http://purl.obolibrary.org/obo/CL_0000080) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- Class: [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061)
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer III](http://purl.obolibrary.org/obo/UBERON_0005392))
-### cnidocyte `http://purl.obolibrary.org/obo/CL_0011029`
-#### Removed
-- [cnidocyte](http://purl.obolibrary.org/obo/CL_0011029) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
+- [L3 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030061) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer III](http://purl.obolibrary.org/obo/UBERON_0005392)
-### colic artery `http://purl.obolibrary.org/obo/UBERON_0035548`
+### L4 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030063`
#### Added
-- [colic artery](http://purl.obolibrary.org/obo/UBERON_0035548) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-
-
-### collar cell `http://purl.obolibrary.org/obo/CL_0010016`
-#### Removed
-- [collar cell](http://purl.obolibrary.org/obo/CL_0010016) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) [label](http://www.w3.org/2000/01/rdf-schema#label) "L4 intratelencephalic projecting glutamatergic neuron"
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) [date](http://purl.org/dc/terms/date) "2023-10-10T14:11:25Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 4."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
-### colon endothelial cell `http://purl.obolibrary.org/obo/CL_1001572`
-#### Removed
-- [colon endothelial cell](http://purl.obolibrary.org/obo/CL_1001572) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "colon endothelial cells"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CALOHA:TS-2397"
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L4 IT"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PLURAL](http://purl.obolibrary.org/obo/caloha-reqs-vetted#PLURAL)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [colon endothelial cell](http://purl.obolibrary.org/obo/CL_1001572) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "colon endothelial cells"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CALOHA:TS-2397"
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- Class: [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063)
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer IV](http://purl.obolibrary.org/obo/UBERON_0005393))
-### columnar/cuboidal epithelial cell `http://purl.obolibrary.org/obo/CL_0000075`
-#### Removed
-- [columnar/cuboidal epithelial cell](http://purl.obolibrary.org/obo/CL_0000075) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer IV](http://purl.obolibrary.org/obo/UBERON_0005393)
+- [L4 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030063) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-### common hepatic artery `http://purl.obolibrary.org/obo/UBERON_0005436`
+### L4/5 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030062`
#### Added
-- [common hepatic artery](http://purl.obolibrary.org/obo/UBERON_0005436) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
-- [common hepatic artery](http://purl.obolibrary.org/obo/UBERON_0005436) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) [date](http://purl.org/dc/terms/date) "2023-10-10T14:11:04Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) [label](http://www.w3.org/2000/01/rdf-schema#label) "L4/5 intratelencephalic projecting glutamatergic neuron"
-### common iliac vein `http://purl.obolibrary.org/obo/UBERON_0001139`
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic with a soma located in cortical layer 4/5."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
-#### Added
-- [common iliac vein](http://purl.obolibrary.org/obo/UBERON_0001139) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L4/5 IT"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [common iliac vein](http://purl.obolibrary.org/obo/UBERON_0001139) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34004146"
+- Class: [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062)
-### compact bone tissue `http://purl.obolibrary.org/obo/UBERON_0001439`
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer IV/V](http://purl.obolibrary.org/obo/UBERON_8440001))
-#### Added
-- [compact bone tissue](http://purl.obolibrary.org/obo/UBERON_0001439) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pelvis.glb"
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-- [compact bone tissue](http://purl.obolibrary.org/obo/UBERON_0001439) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pelvis.glb"
+- [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer IV/V](http://purl.obolibrary.org/obo/UBERON_8440001)
-### conjunctival epithelial cell `http://purl.obolibrary.org/obo/CL_1000432`
+### L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023048`
#### Removed
-- [conjunctival epithelial cell](http://purl.obolibrary.org/obo/CL_1000432) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
-
+- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384)) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer IV/V](http://purl.obolibrary.org/obo/UBERON_8440001))
+- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-### connective tissue cell `http://purl.obolibrary.org/obo/CL_0002320`
-#### Removed
-- [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) EquivalentTo [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [connective tissue](http://purl.obolibrary.org/obo/UBERON_0002384))
-
-- [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer IV/V](http://purl.obolibrary.org/obo/UBERON_8440001)
#### Added
-- [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [connective tissue](http://purl.obolibrary.org/obo/UBERON_0002384))
+- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) EquivalentTo [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384))
-- [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) SubClassOf [L4/5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030062)
-### contains `http://purl.obolibrary.org/obo/RO_0001019`
+### L5 extratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023041`
#### Removed
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [L5 extratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023041) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L5b neuron"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.neuron.2011.07.029"
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [label](http://www.w3.org/2000/01/rdf-schema#label) "contains"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "contains"@en
+#### Added
+- [L5 extratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023041) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L5b neuron"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.neuron.2011.07.029"
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [id](http://www.geneontology.org/formats/oboInOwl#id) "contains"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0001019"
+### L5 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030064`
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete contains"
+#### Added
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) [date](http://purl.org/dc/terms/date) "2023-10-10T14:11:59Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [shorthand](http://www.geneontology.org/formats/oboInOwl#shorthand) "contains"
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) [label](http://www.w3.org/2000/01/rdf-schema#label) "L5 intratelencephalic projecting glutamatergic neuron"
-- [contains](http://purl.obolibrary.org/obo/RO_0001019) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [693](https://github.com/oborel/obo-relations/issues/693)
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L5 IT"
+ - [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- ObjectProperty: [contains](http://purl.obolibrary.org/obo/RO_0001019)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 5."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37609206"
-### contractile cell `http://purl.obolibrary.org/obo/CL_0000183`
-#### Removed
-- [contractile cell](http://purl.obolibrary.org/obo/CL_0000183) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
-#### Added
-- [contractile cell](http://purl.obolibrary.org/obo/CL_0000183) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- Class: [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064)
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer V](http://purl.obolibrary.org/obo/UBERON_0005394))
-### corneocyte `http://purl.obolibrary.org/obo/CL_0002153`
-#### Removed
-- [corneocyte](http://purl.obolibrary.org/obo/CL_0002153) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer V](http://purl.obolibrary.org/obo/UBERON_0005394)
+- [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-### cortex of kidney `http://purl.obolibrary.org/obo/UBERON_0001225`
+### L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023049`
+#### Removed
+- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384)) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer V](http://purl.obolibrary.org/obo/UBERON_0005394))
-#### Added
-- [cortex of kidney](http://purl.obolibrary.org/obo/UBERON_0001225) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_R.glb"
+- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-- [cortex of kidney](http://purl.obolibrary.org/obo/UBERON_0001225) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb"
+- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer V](http://purl.obolibrary.org/obo/UBERON_0005394)
-- [cortex of kidney](http://purl.obolibrary.org/obo/UBERON_0001225) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb"
+#### Added
+- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) EquivalentTo [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384))
-- [cortex of kidney](http://purl.obolibrary.org/obo/UBERON_0001225) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb"
+- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) SubClassOf [L5 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030064)
-### corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023055`
+### L6 intratelencephalic projecting glutamatergic neuron `http://purl.obolibrary.org/obo/CL_4030065`
#### Added
-- [corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023055) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The assertion of this cell type under L6 CT is due to the ambiguity of lower L5 and L6."
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 6."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37609206"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
-### created `http://purl.org/dc/terms/created`
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) [date](http://purl.org/dc/terms/date) "2023-10-10T14:12:23Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-#### Added
-- AnnotationProperty: [created](http://purl.org/dc/terms/created)
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4389-9821](https://orcid.org/0000-0003-4389-9821)
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L6 IT"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37292694"
-### curation status specification `http://purl.obolibrary.org/obo/IAO_0000078`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Bill Bug"@en
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) [label](http://www.w3.org/2000/01/rdf-schema#label) "L6 intratelencephalic projecting glutamatergic neuron"
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+- Class: [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065)
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [label](http://www.w3.org/2000/01/rdf-schema#label) "curation status specification"@en
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer VI](http://purl.obolibrary.org/obo/UBERON_0005395))
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000266"@en
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer VI](http://purl.obolibrary.org/obo/UBERON_0005395)
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en
+- [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)"@en
+### L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023050`
+#### Removed
+- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) EquivalentTo [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384)) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer VI](http://purl.obolibrary.org/obo/UBERON_0005395))
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "curation status specification"@en
+- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [cortical layer VI](http://purl.obolibrary.org/obo/UBERON_0005395)
-- Class: [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078)
+- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) SubClassOf [L2/3-6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4023040)
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) EquivalentTo {[example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) , [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) , [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) , [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) , [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) , [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) , [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) , [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) , [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428)}
+#### Added
+- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) EquivalentTo [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [primary motor cortex](http://purl.obolibrary.org/obo/UBERON_0001384))
-- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) SubClassOf [L6 intratelencephalic projecting glutamatergic neuron](http://purl.obolibrary.org/obo/CL_4030065)
-### cyanoblast `http://purl.obolibrary.org/obo/CL_0005005`
+### ON-blue cone bipolar cell `http://purl.obolibrary.org/obo/CL_4033019`
#### Removed
-- [cyanoblast](http://purl.obolibrary.org/obo/CL_0005005) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [ON-blue cone bipolar cell](http://purl.obolibrary.org/obo/CL_4033019) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BB cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+#### Added
+- [ON-blue cone bipolar cell](http://purl.obolibrary.org/obo/CL_4033019) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BB cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
-### cyanophore `http://purl.obolibrary.org/obo/CL_0000747`
-#### Removed
-- [cyanophore](http://purl.obolibrary.org/obo/CL_0000747) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+### RXFP1-positive interface island D1-medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030054`
+#### Removed
+- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-NUDAP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### cystic artery `http://purl.obolibrary.org/obo/UBERON_0039222`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
#### Added
-- [cystic artery](http://purl.obolibrary.org/obo/UBERON_0039222) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-NUDAP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [cystic artery](http://purl.obolibrary.org/obo/UBERON_0039222) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### cystoblast `http://purl.obolibrary.org/obo/CL_0000722`
+### SMILES `http://purl.obolibrary.org/obo/fbbt#SMILES`
#### Removed
-- [cystoblast](http://purl.obolibrary.org/obo/CL_0000722) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-#### Added
-- [cystoblast](http://purl.obolibrary.org/obo/CL_0000722) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- AnnotationProperty: [SMILES](http://purl.obolibrary.org/obo/fbbt#SMILES)
+- [SMILES](http://purl.obolibrary.org/obo/fbbt#SMILES) SubPropertyOf: [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty)
-### data about an ontology part `http://purl.obolibrary.org/obo/IAO_0000102`
-#### Added
-- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en
-- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Data about an ontology part is a data item about a part of an ontology, for example a term"@en
+### T cell receptor binding `http://purl.obolibrary.org/obo/GO_0042608`
+#### Removed
+- [T cell receptor binding](http://purl.obolibrary.org/obo/GO_0042608) EquivalentTo [protein-containing complex binding](http://purl.obolibrary.org/obo/GO_0044877) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [T cell receptor complex](http://purl.obolibrary.org/obo/GO_0042101))
-- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [label](http://www.w3.org/2000/01/rdf-schema#label) "data about an ontology part"@en
+#### Added
+- [T cell receptor binding](http://purl.obolibrary.org/obo/GO_0042608) EquivalentTo [binding](http://purl.obolibrary.org/obo/GO_0005488) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [T cell receptor complex](http://purl.obolibrary.org/obo/GO_0042101))
-- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data about an ontology part"@en
-- Class: [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+### TCR-positive macrophage `http://purl.obolibrary.org/obo/CL_4030058`
-- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) SubClassOf [data item](http://purl.obolibrary.org/obo/IAO_0000027)
+#### Added
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A macrophage that expresses the T cell receptor complex at the cell surface."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26074923"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0001-9990-8331](https://orcid.org/0000-0001-9990-8331)
-### data item `http://purl.obolibrary.org/obo/IAO_0000027`
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "TCR.macs"
+ - [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [label](http://www.w3.org/2000/01/rdf-schema#label) "data item"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37500727"
-- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data item"@en
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "T cell receptor positive macrophage"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26074923"
-- Class: [data item](http://purl.obolibrary.org/obo/IAO_0000027)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "TCR+ macrophage"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26074923"
-- [data item](http://purl.obolibrary.org/obo/IAO_0000027) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-3308-6245](https://orcid.org/0000-0003-3308-6245)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [label](http://www.w3.org/2000/01/rdf-schema#label) "TCR-positive macrophage"
-### date `http://www.w3.org/2001/XMLSchema#date`
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) [date](http://purl.org/dc/terms/date) "2023-09-26T12:27:14Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-#### Added
-- [date](http://www.w3.org/2001/XMLSchema#date)
+- Class: [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) EquivalentTo [macrophage](http://purl.obolibrary.org/obo/CL_0000235) and ([has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) some [T cell receptor complex](http://purl.obolibrary.org/obo/GO_0042101))
-### defensive cell `http://purl.obolibrary.org/obo/CL_0000473`
-#### Removed
-- [defensive cell](http://purl.obolibrary.org/obo/CL_0000473) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) SubClassOf [macrophage](http://purl.obolibrary.org/obo/CL_0000235)
-#### Added
-- [defensive cell](http://purl.obolibrary.org/obo/CL_0000473) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567)
+- [TCR-positive macrophage](http://purl.obolibrary.org/obo/CL_4030058) SubClassOf [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) some [T cell receptor complex](http://purl.obolibrary.org/obo/GO_0042101)
-### defined by construct `http://purl.obolibrary.org/obo/OMO_0002000`
-#### Added
-- [defined by construct](http://purl.obolibrary.org/obo/OMO_0002000) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "'part disjoint with' 'defined by construct' """
- PREFIX owl: <http://www.w3.org/2002/07/owl#>
- PREFIX : <http://example.org/
- CONSTRUCT {
- [
- a owl:Restriction ;
- owl:onProperty :part_of ;
- owl:someValuesFrom ?a ;
- owl:disjointWith [
- a owl:Restriction ;
- owl:onProperty :part_of ;
- owl:someValuesFrom ?b
- ]
- ]
- }
- WHERE {
- ?a :part_disjoint_with ?b .
- }"
+### abbreviation `http://purl.obolibrary.org/obo/cl#abbreviation`
+#### Removed
+- [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-1773-2692](https://orcid.org/0000-0002-1773-2692)
-- [defined by construct](http://purl.obolibrary.org/obo/OMO_0002000) [contributor](http://purl.org/dc/elements/1.1/contributor) [0000-0002-8688-6599](https://orcid.org/0000-0002-8688-6599)
+- [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) [label](http://www.w3.org/2000/01/rdf-schema#label) "abbreviation"
-- [defined by construct](http://purl.obolibrary.org/obo/OMO_0002000) [label](http://www.w3.org/2000/01/rdf-schema#label) "defined by construct"
+- [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) [date](http://purl.org/dc/elements/1.1/date) "2022-03-29T15:09:49Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [defined by construct](http://purl.obolibrary.org/obo/OMO_0002000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Links an annotation property to a SPARQL CONSTRUCT query which is meant to provide semantics for a shortcut relation."
+- AnnotationProperty: [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [defined by construct](http://purl.obolibrary.org/obo/OMO_0002000) [contributor](http://purl.org/dc/elements/1.1/contributor) [0000-0002-7356-1779](https://orcid.org/0000-0002-7356-1779)
+- [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) SubPropertyOf: [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty)
-- [defined by construct](http://purl.obolibrary.org/obo/OMO_0002000) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [963](https://github.com/ontodev/robot/issues/963)
-### defined class `http://purl.obolibrary.org/obo/IAO_0000420`
+### abbreviation `http://purl.obolibrary.org/obo/OMO_0003000`
#### Added
-- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+- [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
-- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) ""definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal."@en
+- [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000) [label](http://www.w3.org/2000/01/rdf-schema#label) "abbreviation"
-- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "defined class"@en
+- [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A synonym type for describing abbreviations or initalisms"
-- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [label](http://www.w3.org/2000/01/rdf-schema#label) "defined class"@en
+- [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000) [created](http://purl.org/dc/terms/created) "2023-03-03"^^[date](http://www.w3.org/2001/XMLSchema#date)
-- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en
+- [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4423-4370](https://orcid.org/0000-0003-4423-4370)
-- Individual: [defined class](http://purl.obolibrary.org/obo/IAO_0000420)
+- [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [122](https://github.com/information-artifact-ontology/ontology-metadata/issues/122)
+- AnnotationProperty: [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### definition `http://purl.obolibrary.org/obo/IAO_0000115`
-
-#### Added
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "definition"@en
+### acellular anatomical structure `http://purl.obolibrary.org/obo/CARO_0000040`
+#### Removed
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Example. Insect cuticle, eggshell, hair."
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2012-04-05:
-Barry Smith
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) [label](http://www.w3.org/2000/01/rdf-schema#label) "acellular anatomical structure"
-The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000040"
-Can you fix to something like:
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An anatomical structure that has no cells or cell parts as a part."
-A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+- Class: [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040)
-Alan Ruttenberg
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) DisjointWith [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000)
-Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) DisjointWith [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-On the specifics of the proposed definition:
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) DisjointWith [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042)
-We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) EquivalentTo [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) and ([has component](http://purl.obolibrary.org/obo/RO_0002180) exactly 0 [cell](http://purl.obolibrary.org/obo/CARO_0000013)) and ([has component](http://purl.obolibrary.org/obo/RO_0002180) exactly 0 [cell part](http://purl.obolibrary.org/obo/CARO_0000014))
-Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) SubClassOf [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008)
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "@en
+- [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [label](http://www.w3.org/2000/01/rdf-schema#label) "definition"@en
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en
+### acetylcholine binding `http://purl.obolibrary.org/obo/GO_0042166`
+#### Removed
+- [acetylcholine binding](http://purl.obolibrary.org/obo/GO_0042166) SubClassOf [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165)
-- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en
+#### Added
+- [acetylcholine binding](http://purl.obolibrary.org/obo/GO_0042166) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
-### denotator type `http://purl.obolibrary.org/obo/IAO_0000409`
+### acetylcholine biosynthetic process `http://purl.obolibrary.org/obo/GO_0008292`
+#### Removed
+- [acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_0008292) SubClassOf [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136)
#### Added
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are "natural kinds" and the latter arbitrary collections of entities."@en
+- [acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_0008292) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058)
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Barry Smith, Werner Ceusters"@en
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "denotator type"@en
-
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [label](http://www.w3.org/2000/01/rdf-schema#label) "denotator type"@en
+### acetylcholine catabolic process `http://purl.obolibrary.org/obo/GO_0006581`
+#### Removed
+- [acetylcholine catabolic process](http://purl.obolibrary.org/obo/GO_0006581) SubClassOf [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135)
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+#### Added
+- [acetylcholine catabolic process](http://purl.obolibrary.org/obo/GO_0006581) SubClassOf [catabolic process](http://purl.obolibrary.org/obo/GO_0009056)
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A denotator type indicates how a term should be interpreted from an ontological perspective."@en
-- Class: [denotator type](http://purl.obolibrary.org/obo/IAO_0000409)
+### acetylcholine metabolic process `http://purl.obolibrary.org/obo/GO_0008291`
+#### Removed
+- [acetylcholine metabolic process](http://purl.obolibrary.org/obo/GO_0008291) SubClassOf [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133)
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) EquivalentTo {[universal](http://purl.obolibrary.org/obo/IAO_0000410) , [defined class](http://purl.obolibrary.org/obo/IAO_0000420) , [named class expression](http://purl.obolibrary.org/obo/IAO_0000421)}
+#### Added
+- [acetylcholine metabolic process](http://purl.obolibrary.org/obo/GO_0008291) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152)
-- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+### acetylcholine-gated monoatomic cation-selective channel activity `http://purl.obolibrary.org/obo/GO_0022848`
+#### Removed
+- [acetylcholine-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022848) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([regulated by](http://purl.obolibrary.org/obo/RO_0002334) some [acetylcholine binding](http://purl.obolibrary.org/obo/GO_0042166)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906))
-### depiction `http://xmlns.com/foaf/0.1/depiction`
+- [acetylcholine-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022848) SubClassOf [regulated by](http://purl.obolibrary.org/obo/RO_0002334) some [acetylcholine binding](http://purl.obolibrary.org/obo/GO_0042166)
#### Added
-- AnnotationProperty: [depiction](http://xmlns.com/foaf/0.1/depiction)
+- [acetylcholine-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022848) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355))
+- [acetylcholine-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022848) SubClassOf [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_15355](http://purl.obolibrary.org/obo/CHEBI_15355)
-### descending aorta `http://purl.obolibrary.org/obo/UBERON_0001514`
+
+### airway submucosal gland duct ciliated cell `http://purl.obolibrary.org/obo/CL_4033055`
#### Added
-- [descending aorta](http://purl.obolibrary.org/obo/UBERON_0001514) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [descending aorta](http://purl.obolibrary.org/obo/UBERON_0001514) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [airway submucosal gland duct ciliated cell](http://purl.obolibrary.org/obo/CL_4033055) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### descending colon `http://purl.obolibrary.org/obo/UBERON_0001158`
+### alveolar capillary type 1 endothelial cell `http://purl.obolibrary.org/obo/CL_4028002`
+#### Removed
+- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gCAP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33057196"
-#### Added
-- [descending colon](http://purl.obolibrary.org/obo/UBERON_0001158) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [descending colon](http://purl.obolibrary.org/obo/UBERON_0001158) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
+- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CAP1"
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+#### Added
+- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gCAP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33057196"
-### diffuse bistratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004230`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [diffuse bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004230) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CAP1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### diffuse multistratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004234`
+### alveolar capillary type 2 endothelial cell `http://purl.obolibrary.org/obo/CL_4028003`
#### Removed
-- [diffuse multistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004234) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [alveolar capillary type 2 endothelial cell](http://purl.obolibrary.org/obo/CL_4028003) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "aCAP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [diffuse multistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004234) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
+- [alveolar capillary type 2 endothelial cell](http://purl.obolibrary.org/obo/CL_4028003) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "aCAP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### diploid cell `http://purl.obolibrary.org/obo/CL_0000415`
+### alveolar type 1 fibroblast cell `http://purl.obolibrary.org/obo/CL_4028004`
#### Removed
-- [diploid cell](http://purl.obolibrary.org/obo/CL_0000415) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [alveolar type 1 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028004) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AF1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [diploid cell](http://purl.obolibrary.org/obo/CL_0000415) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [alveolar type 1 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028004) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AF1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### distal tip cell (sensu Nematoda) `http://purl.obolibrary.org/obo/CL_0000661`
+### alveolar type 2 fibroblast cell `http://purl.obolibrary.org/obo/CL_4028006`
#### Removed
-- [distal tip cell (sensu Nematoda)](http://purl.obolibrary.org/obo/CL_0000661) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AF2"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MANC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+#### Added
+- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MANC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### duct epithelial cell `http://purl.obolibrary.org/obo/CL_0000068`
-#### Removed
-- [duct epithelial cell](http://purl.obolibrary.org/obo/CL_0000068) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AF2"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+### amacrine cell `http://purl.obolibrary.org/obo/CL_0000561`
+#### Removed
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+
+#### Added
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+
+
+### anatomical boundary `http://purl.obolibrary.org/obo/CARO_0000010`
+#### Removed
+- [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms."
+
+- [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010) [label](http://www.w3.org/2000/01/rdf-schema#label) "anatomical boundary"
+
+- [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures."
+
+- Class: [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010)
+
+- [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010) SubClassOf [BFO_0000009](http://purl.obolibrary.org/obo/BFO_0000009)
+
+- [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010) SubClassOf [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007)
+
+
+
+### anatomical entity `http://purl.obolibrary.org/obo/CARO_0000000`
+#### Removed
+- [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) [label](http://www.w3.org/2000/01/rdf-schema#label) "anatomical entity"
+
+- [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CAROC:Brownsville2014"
+
+- [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000000"
+
+- [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure."
+
+- [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) DisjointUnionOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006), [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007)
+
+- [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) SubClassOf [biological entity](http://purl.obolibrary.org/obo/CARO_0030000)
+
+
+
+### angioblastic mesenchymal cell `http://purl.obolibrary.org/obo/CL_0000566`
+#### Removed
+- [angioblastic mesenchymal cell](http://purl.obolibrary.org/obo/CL_0000566) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [angioblastic mesenchymal cell](http://purl.obolibrary.org/obo/CL_0000566) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+
+### animal organ development `http://purl.obolibrary.org/obo/GO_0048513`
+#### Removed
+- [animal organ development](http://purl.obolibrary.org/obo/GO_0048513) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [organ](http://purl.obolibrary.org/obo/UBERON_0000062))
+
+- [animal organ development](http://purl.obolibrary.org/obo/GO_0048513) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [organ](http://purl.obolibrary.org/obo/UBERON_0000062)
+
+#### Added
+- [animal organ development](http://purl.obolibrary.org/obo/GO_0048513) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25943"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### arachnoid barrier cell `http://purl.obolibrary.org/obo/CL_4023097`
+#### Removed
+- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AB cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23298861"
+
+- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ABC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096314"
+
+#### Added
+- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ABC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096314"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AB cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23298861"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### articular chondrocyte `http://purl.obolibrary.org/obo/CL_1001607`
+
+#### Added
+- [articular chondrocyte](http://purl.obolibrary.org/obo/CL_1001607) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [articular chondrocyte](http://purl.obolibrary.org/obo/CL_1001607) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+
+### baculum development `http://purl.obolibrary.org/obo/GO_1990375`
+#### Removed
+- [baculum development](http://purl.obolibrary.org/obo/GO_1990375) SubClassOf [bone development](http://purl.obolibrary.org/obo/GO_0060348)
+
+
+
+### basal cell of urothelium `http://purl.obolibrary.org/obo/CL_1000486`
+
+#### Added
+- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### basophil activation involved in immune response `http://purl.obolibrary.org/obo/GO_0002276`
+#### Removed
+- [basophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002276) SubClassOf [myeloid cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002275)
+
+#### Added
+- [basophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002276) SubClassOf [leukocyte activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002366)
+
+- [basophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002276) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [myeloid cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002275)
+
+
+### basophil degranulation `http://purl.obolibrary.org/obo/GO_0002561`
+#### Removed
+- [basophil degranulation](http://purl.obolibrary.org/obo/GO_0002561) SubClassOf [basophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002276)
+
+#### Added
+- [basophil degranulation](http://purl.obolibrary.org/obo/GO_0002561) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [basophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002276)
+
+
+### bile acid catabolic process `http://purl.obolibrary.org/obo/GO_0030573`
+#### Removed
+- [bile acid catabolic process](http://purl.obolibrary.org/obo/GO_0030573) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MetaCyc:7ALPHADEHYDROX-PWY"
+
+
+
+### biological entity `http://purl.obolibrary.org/obo/CARO_0030000`
+#### Removed
+- [biological entity](http://purl.obolibrary.org/obo/CARO_0030000) [label](http://www.w3.org/2000/01/rdf-schema#label) "biological entity"
+
+- [biological entity](http://purl.obolibrary.org/obo/CARO_0030000) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Important for alignment with Darwin Core class "Organism"."
+
+- [biological entity](http://purl.obolibrary.org/obo/CARO_0030000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
+
+- Class: [biological entity](http://purl.obolibrary.org/obo/CARO_0030000)
+
+- [biological entity](http://purl.obolibrary.org/obo/CARO_0030000) SubClassOf [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004)
+
+
+
+### blood vessel remodeling `http://purl.obolibrary.org/obo/GO_0001974`
+
+#### Added
+- [blood vessel remodeling](http://purl.obolibrary.org/obo/GO_0001974) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "blood vessel remodelling"
+
+
+### bone marrow macrophage `http://purl.obolibrary.org/obo/CL_0002476`
+#### Removed
+- [bone marrow macrophage](http://purl.obolibrary.org/obo/CL_0002476) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MF.BM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [bone marrow macrophage](http://purl.obolibrary.org/obo/CL_0002476) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MF.BM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### boundary_of `http://purl.obolibrary.org/obo/RO_0002000`
+#### Removed
+- [boundary_of](http://purl.obolibrary.org/obo/RO_0002000) [label](http://www.w3.org/2000/01/rdf-schema#label) "boundary_of"
+
+
+
+### calcium activated cation channel activity `http://purl.obolibrary.org/obo/GO_0005227`
+#### Removed
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium activated cation channel activity"
+
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([positively regulated by](http://purl.obolibrary.org/obo/RO_0002336) some [calcium ion binding](http://purl.obolibrary.org/obo/GO_0005509)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906))
+
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) SubClassOf [positively regulated by](http://purl.obolibrary.org/obo/RO_0002336) some [calcium ion binding](http://purl.obolibrary.org/obo/GO_0005509)
+
+#### Added
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium activated cation channel activity"
+
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium-activated cation channel activity"
+
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124))
+
+- [calcium activated cation channel activity](http://purl.obolibrary.org/obo/GO_0005227) SubClassOf [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124)
+
+
+### calcium-release channel activity `http://purl.obolibrary.org/obo/GO_0015278`
+#### Removed
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0005218"
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9717215"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol"
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "intracellular ligand-gated calcium channel activity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO:0015278"
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0015278"
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium-release channel activity"
+
+- Class: [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278)
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108))
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) SubClassOf [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217)
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)
+
+- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) SubClassOf [ligand-gated calcium channel activity](http://purl.obolibrary.org/obo/GO_0099604)
+
+
+
+### cardioblast `http://purl.obolibrary.org/obo/CL_0002664`
+#### Removed
+- [cardioblast](http://purl.obolibrary.org/obo/CL_0002664) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CPC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19745164"
+
+#### Added
+- [cardioblast](http://purl.obolibrary.org/obo/CL_0002664) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CPC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19745164"
+
+
+### cell `http://purl.obolibrary.org/obo/CARO_0000013`
+#### Removed
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000013"
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) [label](http://www.w3.org/2000/01/rdf-schema#label) "cell"
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "deprecate and replace with CL or GO term?"
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane."
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO:0005623"
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CL:0000000"
+
+- Class: [cell](http://purl.obolibrary.org/obo/CARO_0000013)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) DisjointWith [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) DisjointWith [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) DisjointWith [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) DisjointWith [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) DisjointWith [cell part](http://purl.obolibrary.org/obo/CARO_0000014)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+- [cell](http://purl.obolibrary.org/obo/CARO_0000013) SubClassOf [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003)
+
+
+
+### cell part `http://purl.obolibrary.org/obo/CARO_0000014`
+#### Removed
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) [label](http://www.w3.org/2000/01/rdf-schema#label) "cell part"@en
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000014"
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anatomical structure that is part of a cell and that has a granularity level equal to that of a protein complex or higher."
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "cell component"
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "This is declared equivalent with GO:0044464. The definition should be co-ordinated with GO. We could obsolete the CARO class and just use the GO class."
+
+- Class: [cell part](http://purl.obolibrary.org/obo/CARO_0000014)
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) DisjointWith [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040)
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) DisjointWith [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000)
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) DisjointWith [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042)
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) DisjointWith [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cell](http://purl.obolibrary.org/obo/CARO_0000013)
+
+- [cell part](http://purl.obolibrary.org/obo/CARO_0000014) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+
+
+### cellular anatomical entity `http://purl.obolibrary.org/obo/GO_0110165`
+
+#### Added
+- [cellular anatomical entity](http://purl.obolibrary.org/obo/GO_0110165) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+
+- [cellular anatomical entity](http://purl.obolibrary.org/obo/GO_0110165) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/24200"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### cellular anatomical structure `http://purl.obolibrary.org/obo/CARO_0020003`
+#### Removed
+- [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+- [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2018-09-28T14:20:19Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+
+- [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An anatomical structure consisting of one or more cells."
+
+- [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003) [label](http://www.w3.org/2000/01/rdf-schema#label) "cellular anatomical structure"@en
+
+- Class: [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003)
+
+- [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003) EquivalentTo [cell](http://purl.obolibrary.org/obo/CARO_0000013) or ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cell](http://purl.obolibrary.org/obo/CARO_0000013))
+ - [definition](http://purl.obolibrary.org/obo/IAO_0000115) "With a reflexive part_of relation this might safely be defined as 'anatomical structure' that has_part some cell"
+
+- [cellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0020003) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### cellular organism `http://purl.obolibrary.org/obo/CARO_0010004`
+#### Removed
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) [IAO_creation_date](http://purl.obolibrary.org/obo/IAO_creation_date) "7.16.2011"
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0010004"
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) [label](http://www.w3.org/2000/01/rdf-schema#label) "cellular organism"
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. "
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An individual member of a clade of cellular organisms."
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-9114-8737](https://orcid.org/0000-0001-9114-8737)
+
+- Class: [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004)
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+- [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004) SubClassOf [organism](http://purl.obolibrary.org/obo/CARO_0001010)
+
+
+
+### cerebellar granule cell precursor `http://purl.obolibrary.org/obo/CL_0002362`
+#### Removed
+- [cerebellar granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GCP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
+
+#### Added
+- [cerebellar granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GCP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### chandelier cell `http://purl.obolibrary.org/obo/CL_4023083`
+#### Removed
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling a chandelier. Chandelier cells can be multipolar or bitufted."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15378039"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27199673"
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ChC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15378039"
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) EquivalentTo [interneuron](http://purl.obolibrary.org/obo/CL_0000099) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [chandelier cell morphology](http://purl.obolibrary.org/obo/PATO_0070011))
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) SubClassOf [interneuron](http://purl.obolibrary.org/obo/CL_0000099)
+
+#### Added
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "axo-axonic cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33862423"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27199673"
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ChC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15378039"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A GABAergic interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling the candlesticks and candles of a chandelier. Chandelier cells can be multipolar or bitufted."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15378039"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27199673"
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) EquivalentTo [GABAergic interneuron](http://purl.obolibrary.org/obo/CL_0011005) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [chandelier cell morphology](http://purl.obolibrary.org/obo/PATO_0070011))
+
+- [chandelier cell](http://purl.obolibrary.org/obo/CL_4023083) SubClassOf [GABAergic interneuron](http://purl.obolibrary.org/obo/CL_0011005)
+
+
+### chordate pharynx development `http://purl.obolibrary.org/obo/GO_0160093`
+
+#### Added
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2023-08-29T21:05:28Z"
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0160093"
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/18285"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [label](http://www.w3.org/2000/01/rdf-schema#label) "chordate pharynx development"
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23020903"
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rynl"
+
+- Class: [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093)
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [chordate pharynx](http://purl.obolibrary.org/obo/UBERON_0001042))
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [chordate pharynx](http://purl.obolibrary.org/obo/UBERON_0001042)
+
+- [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093) SubClassOf [pharynx development](http://purl.obolibrary.org/obo/GO_0060465)
+
+
+### chorion syncytiotrophoblast `http://purl.obolibrary.org/obo/UBERON_0003224`
+
+#### Added
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "TODO - check"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An extraembryonic structure that develops_from a syncytiotrophoblast and is part of a chorion."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0001973"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA:156"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0003224"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) [label](http://www.w3.org/2000/01/rdf-schema#label) "chorion syncytiotrophoblast"
+
+- Class: [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224)
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) EquivalentTo [extraembryonic structure](http://purl.obolibrary.org/obo/UBERON_0000478) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [chorion membrane](http://purl.obolibrary.org/obo/UBERON_0003124)) and ([develops from](http://purl.obolibrary.org/obo/RO_0002202) some [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371))
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) SubClassOf [extraembryonic structure](http://purl.obolibrary.org/obo/UBERON_0000478)
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371)
+ - [notes](http://www.geneontology.org/formats/oboInOwl#notes) "polar trophectoderm syncytiotrophoblast"
+
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "EHDAA2"
+
+- [chorion syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0003224) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [chorion membrane](http://purl.obolibrary.org/obo/UBERON_0003124)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "EHDAA2"
+
+
+### chorionic membrane mesenchymal stem cell `http://purl.obolibrary.org/obo/CL_0002541`
+
+#### Added
+- [chorionic membrane mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0002541) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [chorionic membrane mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0002541) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+
+### choroid plexus epithelial cell `http://purl.obolibrary.org/obo/CL_0000706`
+
+#### Added
+- [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### collagen fibril binding `http://purl.obolibrary.org/obo/GO_0098633`
+#### Removed
+- [collagen fibril binding](http://purl.obolibrary.org/obo/GO_0098633) SubClassOf [protein-containing complex binding](http://purl.obolibrary.org/obo/GO_0044877)
+
+#### Added
+- [collagen fibril binding](http://purl.obolibrary.org/obo/GO_0098633) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
+
+
+### common lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0000051`
+#### Removed
+- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CLP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CLP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### common myeloid progenitor `http://purl.obolibrary.org/obo/CL_0000049`
+#### Removed
+- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CMP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+#### Added
+- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CMP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+
+### common myeloid progenitor, CD34-positive `http://purl.obolibrary.org/obo/CL_0001059`
+#### Removed
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CMP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+#### Added
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CMP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437"
+
+
+### connected anatomical structure `http://purl.obolibrary.org/obo/CARO_0000003`
+#### Removed
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000003"
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development."
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) [label](http://www.w3.org/2000/01/rdf-schema#label) "connected anatomical structure"
+
+- Class: [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+- DisjointClasses: [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003), [organism substance](http://purl.obolibrary.org/obo/CARO_0000004), [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000)
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) EquivalentTo [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [3-D shape](http://purl.obolibrary.org/obo/PATO_0002266)) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000))
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000)
+
+- [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [3-D shape](http://purl.obolibrary.org/obo/PATO_0002266)
+
+
+
+### connective tissue cell `http://purl.obolibrary.org/obo/CL_0002320`
+#### Removed
+- [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+
+
+### core `http://purl.obolibrary.org/obo/caro#core`
+#### Removed
+- AnnotationProperty: [core](http://purl.obolibrary.org/obo/caro#core)
+
+- [core](http://purl.obolibrary.org/obo/caro#core) SubPropertyOf: [subset_property](http://www.geneontology.org/formats/oboInOwl#SubsetProperty)
+
+
+
+### corticothalamic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023013`
+
+#### Added
+- [corticothalamic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023013) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [corticothalamic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023013) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### cytotoxic T cell degranulation `http://purl.obolibrary.org/obo/GO_0043316`
+#### Removed
+- [cytotoxic T cell degranulation](http://purl.obolibrary.org/obo/GO_0043316) SubClassOf [T cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002286)
+
+#### Added
+- [cytotoxic T cell degranulation](http://purl.obolibrary.org/obo/GO_0043316) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [T cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002286)
+
+
+### decidual natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002343`
+
+#### Added
+- [decidual natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002343) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [decidual natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002343) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+
+### decreased mass `http://purl.obolibrary.org/obo/PATO_0001562`
+#### Removed
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [id](http://www.geneontology.org/formats/oboInOwl#id) "PATO:0001562"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [RO_0002604](http://purl.obolibrary.org/obo/RO_0002604) [increased mass](http://purl.obolibrary.org/obo/PATO_0001563)
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "low mass"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "PATO:0000579"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A mass which is lower than normal or average."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PATO:GVG"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "quality"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small mass"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [label](http://www.w3.org/2000/01/rdf-schema#label) "decreased mass"
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [value_slim](http://purl.obolibrary.org/obo/pato#value_slim)
+
+- Class: [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562)
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) EquivalentTo [mass](http://purl.obolibrary.org/obo/PATO_0000125) and ([decreased in magnitude relative to](http://purl.obolibrary.org/obo/RO_0015008) some [normal](http://purl.obolibrary.org/obo/PATO_0000461))
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) SubClassOf [mass](http://purl.obolibrary.org/obo/PATO_0000125)
+
+- [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562) SubClassOf [decreased object quality](http://purl.obolibrary.org/obo/PATO_0002303)
+
+
+
+### definition `http://purl.obolibrary.org/obo/IAO_0000115`
+#### Removed
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "@en
+
+#### Added
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."@en
+
+
+### dental pulp stem cell `http://purl.obolibrary.org/obo/CL_4030035`
+#### Removed
+- [dental pulp stem cell](http://purl.obolibrary.org/obo/CL_4030035) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "DPSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [dental pulp stem cell](http://purl.obolibrary.org/obo/CL_4030035) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "DPSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### dentate gyrus mossy fiber `http://purl.obolibrary.org/obo/GO_0044302`
+#### Removed
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [label](http://www.w3.org/2000/01/rdf-schema#label) "dentate gyrus mossy fiber"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0044302"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Distinctive, unmyelinated axons produced by dentate gyrus granule cells."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:nlx_subcell_20090601"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-02-05T11:23:55Z"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:nlx_subcell_20090601"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dentate gyrus mossy fibre"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell axon"
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component"
+
+- Class: [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302)
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) SubClassOf [axon](http://purl.obolibrary.org/obo/GO_0030424)
+
+- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dentate gyrus granule cell](http://purl.obolibrary.org/obo/CL_2000089)
+
+
+
+### depicted by `http://xmlns.com/foaf/0.1/depicted_by`
+#### Removed
+- [depicted by](http://xmlns.com/foaf/0.1/depicted_by) [is_metadata_tag](http://www.geneontology.org/formats/oboInOwl#is_metadata_tag) true
+
+- [depicted by](http://xmlns.com/foaf/0.1/depicted_by) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+
+- [depicted by](http://xmlns.com/foaf/0.1/depicted_by) [id](http://www.geneontology.org/formats/oboInOwl#id) "depicted_by"
+
+- [depicted by](http://xmlns.com/foaf/0.1/depicted_by) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://xmlns.com/foaf/0.1/depicted_by"
+
+- [depicted by](http://xmlns.com/foaf/0.1/depicted_by) [label](http://www.w3.org/2000/01/rdf-schema#label) "depicted by"
+
+- [depicted by](http://xmlns.com/foaf/0.1/depicted_by) [shorthand](http://www.geneontology.org/formats/oboInOwl#shorthand) "depicted_by"
+
+
+
+### deuterosomal cell `http://purl.obolibrary.org/obo/CL_4033044`
+
+#### Added
+- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+
+### differentiation-committed oligodendrocyte precursor `http://purl.obolibrary.org/obo/CL_4023059`
+#### Removed
+- [differentiation-committed oligodendrocyte precursor](http://purl.obolibrary.org/obo/CL_4023059) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "COP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [differentiation-committed oligodendrocyte precursor](http://purl.obolibrary.org/obo/CL_4023059) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "COP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### diffuse bipolar 1 cell `http://purl.obolibrary.org/obo/CL_4033027`
+#### Removed
+- [diffuse bipolar 1 cell](http://purl.obolibrary.org/obo/CL_4033027) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB1 bipolar cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22006647"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+- [diffuse bipolar 1 cell](http://purl.obolibrary.org/obo/CL_4033027) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB1 cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+- [diffuse bipolar 1 cell](http://purl.obolibrary.org/obo/CL_4033027) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB1 bipolar"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22006647"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [diffuse bipolar 1 cell](http://purl.obolibrary.org/obo/CL_4033027) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB1 bipolar cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22006647"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [diffuse bipolar 1 cell](http://purl.obolibrary.org/obo/CL_4033027) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB1 cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [diffuse bipolar 1 cell](http://purl.obolibrary.org/obo/CL_4033027) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB1 bipolar"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22006647"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### diffuse bipolar 2 cell `http://purl.obolibrary.org/obo/CL_4033028`
+#### Removed
+- [diffuse bipolar 2 cell](http://purl.obolibrary.org/obo/CL_4033028) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB2 cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+#### Added
+- [diffuse bipolar 2 cell](http://purl.obolibrary.org/obo/CL_4033028) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB2 cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### diffuse bipolar 3a cell `http://purl.obolibrary.org/obo/CL_4033029`
+#### Removed
+- [diffuse bipolar 3a cell](http://purl.obolibrary.org/obo/CL_4033029) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB3 cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.3389/fnana.2015.00122"
+
+- [diffuse bipolar 3a cell](http://purl.obolibrary.org/obo/CL_4033029) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB3a cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+#### Added
+- [diffuse bipolar 3a cell](http://purl.obolibrary.org/obo/CL_4033029) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB3 cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.3389/fnana.2015.00122"
+
+- [diffuse bipolar 3a cell](http://purl.obolibrary.org/obo/CL_4033029) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB3a cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### diffuse bipolar 3b cell `http://purl.obolibrary.org/obo/CL_4033030`
+#### Removed
+- [diffuse bipolar 3b cell](http://purl.obolibrary.org/obo/CL_4033030) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB3b cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+#### Added
+- [diffuse bipolar 3b cell](http://purl.obolibrary.org/obo/CL_4033030) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB3b cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### diffuse bipolar 4 cell `http://purl.obolibrary.org/obo/CL_4033031`
+#### Removed
+- [diffuse bipolar 4 cell](http://purl.obolibrary.org/obo/CL_4033031) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB4 cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+#### Added
+- [diffuse bipolar 4 cell](http://purl.obolibrary.org/obo/CL_4033031) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB4 cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### diffuse bipolar 6 cell `http://purl.obolibrary.org/obo/CL_4033032`
+#### Removed
+- [diffuse bipolar 6 cell](http://purl.obolibrary.org/obo/CL_4033032) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB6 cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+#### Added
+- [diffuse bipolar 6 cell](http://purl.obolibrary.org/obo/CL_4033032) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "DB6 cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### direct pathway medium spiny neuron `http://purl.obolibrary.org/obo/CL_4023026`
+#### Removed
+- [direct pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023026) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dSPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096299"
+
+- [direct pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023026) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "D1-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34727523"
+
+#### Added
+- [direct pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023026) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "D1-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34727523"
+
+- [direct pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023026) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dSPN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096299"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### disconnected anatomical group `http://purl.obolibrary.org/obo/CARO_0020000`
+#### Removed
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000054"
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) [label](http://www.w3.org/2000/01/rdf-schema#label) "disconnected anatomical group"
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other."
+
+- Class: [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000)
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) EquivalentTo [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [disconnected](http://purl.obolibrary.org/obo/PATO_0010001)) and ([has component](http://purl.obolibrary.org/obo/RO_0002180) min 2 [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003))
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) SubClassOf [has component](http://purl.obolibrary.org/obo/RO_0002180) some [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+- [disconnected anatomical group](http://purl.obolibrary.org/obo/CARO_0020000) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [disconnected](http://purl.obolibrary.org/obo/PATO_0010001)
+
+
+
+### distal limb integumentary appendage `http://purl.obolibrary.org/obo/UBERON_0009564`
+
+#### Added
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D006724"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0009564"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "unguis"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "keratin sheath"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A nail, hoof or claw."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11710767"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [label](http://www.w3.org/2000/01/rdf-schema#label) "distal limb integumentary appendage"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hoof, claw or nail"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-### duct of eccrine sweat gland `http://purl.obolibrary.org/obo/UBERON_0035073`
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hoof or claw"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "keratin plate"
+
+- Class: [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564)
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [distal segment of digit](http://purl.obolibrary.org/obo/UBERON_0009551)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "cjm"
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) SubClassOf [integumentary projection](http://purl.obolibrary.org/obo/UBERON_0013703)
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [skin epidermis](http://purl.obolibrary.org/obo/UBERON_0001003)
+
+- [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [embryonic skin basal layer](http://purl.obolibrary.org/obo/UBERON_0011272)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipathways:WP2062"
+
+
+### dorsal skin of digit `http://purl.obolibrary.org/obo/UBERON_0005275`
#### Added
-- [duct of eccrine sweat gland](http://purl.obolibrary.org/obo/UBERON_0035073) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A duct made up of simple tubular epithelium that is part of an eccrine sweat gland. The main function of the duct of the eccrine sweat gland is the reabsorption of Na and Cl ions as sweat flows through the duct. It has two cell layers: basal and luminal. It is continuous with the secretory coil and goes towards the skin surface. The distal segment of the duct is relatively straight and connects with the acrosyringium in the epidermis. Most of the ion reabsorption occurs in the proximal part of the duct."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31608304"
+- [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "skin of dorsal part of digit"
+- [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-### duodenal papilla `http://purl.obolibrary.org/obo/UBERON_0004914`
+- [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005275"
+
+- [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dorsal digit skin"
+
+- [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) [label](http://www.w3.org/2000/01/rdf-schema#label) "dorsal skin of digit"
+
+- Class: [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275)
+
+- [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) SubClassOf [digit skin](http://purl.obolibrary.org/obo/UBERON_0015249)
+
+
+### dorsal skin of finger `http://purl.obolibrary.org/obo/UBERON_0005276`
#### Added
-- [duodenal papilla](http://purl.obolibrary.org/obo/UBERON_0004914) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb"
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A dorsal skin of digit that is part of a manual digit."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [UBPROP_0000012](http://purl.obolibrary.org/obo/UBPROP_0000012) "this class is explicitly the union of the two FMA classes"
+ - [external_ontology](http://www.geneontology.org/formats/oboInOwl#external_ontology) "FMA"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:60346"
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [label](http://www.w3.org/2000/01/rdf-schema#label) "dorsal skin of finger"
-### duodenum `http://purl.obolibrary.org/obo/UBERON_0002114`
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "subdivision of skin of dorsal part of finger"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:60346"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "skin of dorsal part of finger"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:38320"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:38320"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005276"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dorsal finger skin"
+
+- Class: [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276)
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) EquivalentTo [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [manual digit](http://purl.obolibrary.org/obo/UBERON_0002389))
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) SubClassOf [manual digit skin](http://purl.obolibrary.org/obo/UBERON_0003533)
+
+- [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276) SubClassOf [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275)
+
+
+### dorsal skin of toe `http://purl.obolibrary.org/obo/UBERON_0005277`
#### Added
-- [duodenum](http://purl.obolibrary.org/obo/UBERON_0002114) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb"
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:37868"
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [UBPROP_0000012](http://purl.obolibrary.org/obo/UBPROP_0000012) "this class is explicitly the union of the two FMA classes"
+ - [external_ontology](http://www.geneontology.org/formats/oboInOwl#external_ontology) "FMA"
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:60523"
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "skin of dorsal part of toe"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:37868"
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [label](http://www.w3.org/2000/01/rdf-schema#label) "dorsal skin of toe"
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "subdivision of skin of dorsal part of toe"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:60523"
-- [duodenum](http://purl.obolibrary.org/obo/UBERON_0002114) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb"
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A dorsal skin of digit that is part of a pedal digit."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
-### ecto-epithelial cell `http://purl.obolibrary.org/obo/CL_0002077`
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dorsal toe skin"
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005277"
+
+- Class: [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277)
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) EquivalentTo [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pedal digit](http://purl.obolibrary.org/obo/UBERON_0001466))
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) SubClassOf [dorsal skin of digit](http://purl.obolibrary.org/obo/UBERON_0005275)
+
+- [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277) SubClassOf [pedal digit skin](http://purl.obolibrary.org/obo/UBERON_0003530)
+
+
+### early lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0000936`
#### Removed
-- [ecto-epithelial cell](http://purl.obolibrary.org/obo/CL_0002077) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMLP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18371378"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### editor note `http://purl.obolibrary.org/obo/IAO_0000116`
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LMPP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "editor note"@en
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LMPP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMLP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18371378"
-- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### eccentric medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030057`
+#### Removed
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eSPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obofoundry.org/obo/obi>"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
-- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [label](http://www.w3.org/2000/01/rdf-schema#label) "editor note"@en
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898"
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric SPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### efferent lymphatic vessel `http://purl.obolibrary.org/obo/UBERON_0010397`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
#### Added
-- [efferent lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0010397) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898"
-- [efferent lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0010397) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric SPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eSPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
### egg cell `http://purl.obolibrary.org/obo/CL_0000025`
#### Removed
-- [egg cell](http://purl.obolibrary.org/obo/CL_0000025) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [egg cell](http://purl.obolibrary.org/obo/CL_0000025) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Egg_cell.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+#### Added
+- [egg cell](http://purl.obolibrary.org/obo/CL_0000025) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://www.swissbiopics.org/api/image/Egg_cell.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### embryonic organ development `http://purl.obolibrary.org/obo/GO_0048568`
+
+#### Added
+- [embryonic organ development](http://purl.obolibrary.org/obo/GO_0048568) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [organ](http://purl.obolibrary.org/obo/UBERON_0000062)
+
+
+### endocrine-paracrine cell of prostate gland `http://purl.obolibrary.org/obo/CL_0002313`
+#### Removed
+- [endocrine-paracrine cell of prostate gland](http://purl.obolibrary.org/obo/CL_0002313) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [endocrine-paracrine cell of prostate gland](http://purl.obolibrary.org/obo/CL_0002313) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### ejaculatory duct `http://purl.obolibrary.org/obo/UBERON_0000999`
+
+### enucleate erythrocyte `http://purl.obolibrary.org/obo/CL_0000595`
+#### Removed
+- [enucleate erythrocyte](http://purl.obolibrary.org/obo/CL_0000595) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RBC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [enucleate erythrocyte](http://purl.obolibrary.org/obo/CL_0000595) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RBC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### eosinophil degranulation `http://purl.obolibrary.org/obo/GO_0043308`
+#### Removed
+- [eosinophil degranulation](http://purl.obolibrary.org/obo/GO_0043308) SubClassOf [eosinophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002278)
+
+#### Added
+- [eosinophil degranulation](http://purl.obolibrary.org/obo/GO_0043308) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [eosinophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002278)
+
+
+### eosinophil progenitor cell `http://purl.obolibrary.org/obo/CL_0000611`
+#### Removed
+- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-Eo"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "EoP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2212039"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2626675"
#### Added
-- [ejaculatory duct](http://purl.obolibrary.org/obo/UBERON_0000999) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb"
+- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-Eo"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "EoP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2212039"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2626675"
-### electrically active cell `http://purl.obolibrary.org/obo/CL_0000211`
+
+### epithelial cell `http://purl.obolibrary.org/obo/CL_0000066`
#### Removed
-- [electrically active cell](http://purl.obolibrary.org/obo/CL_0000211) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+#### Added
+- [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### epithelial cell of endometrial gland `http://purl.obolibrary.org/obo/CL_0009084`
#### Added
-- [electrically active cell](http://purl.obolibrary.org/obo/CL_0000211) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [epithelial cell of endometrial gland](http://purl.obolibrary.org/obo/CL_0009084) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [epithelial cell of endometrial gland](http://purl.obolibrary.org/obo/CL_0009084) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### epithelial cell of lung `http://purl.obolibrary.org/obo/CL_0000082`
+#### Removed
+- [epithelial cell of lung](http://purl.obolibrary.org/obo/CL_0000082) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [epithelial cell of lung](http://purl.obolibrary.org/obo/CL_0000082) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
-### embryonic blood vessel endothelial progenitor cell `http://purl.obolibrary.org/obo/CL_0002546`
+### epithelial cell of tracheobronchial tree `http://purl.obolibrary.org/obo/CL_0002202`
#### Removed
-- [embryonic blood vessel endothelial progenitor cell](http://purl.obolibrary.org/obo/CL_0002546) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [epithelial cell of tracheobronchial tree](http://purl.obolibrary.org/obo/CL_0002202) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [epithelial cell of tracheobronchial tree](http://purl.obolibrary.org/obo/CL_0002202) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### embryonic cell (metazoa) `http://purl.obolibrary.org/obo/CL_0002321`
+
+### erythroid progenitor cell `http://purl.obolibrary.org/obo/CL_0000038`
+#### Removed
+- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### erythroid progenitor cell, mammalian `http://purl.obolibrary.org/obo/CL_0001066`
#### Removed
-- [embryonic cell (metazoa)](http://purl.obolibrary.org/obo/CL_0002321) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [embryonic cell (metazoa)](http://purl.obolibrary.org/obo/CL_0002321) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### endo-epithelial cell `http://purl.obolibrary.org/obo/CL_0002076`
+### esophagus development `http://purl.obolibrary.org/obo/GO_1903702`
#### Removed
-- [endo-epithelial cell](http://purl.obolibrary.org/obo/CL_0002076) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [esophagus development](http://purl.obolibrary.org/obo/GO_1903702) SubClassOf [animal organ development](http://purl.obolibrary.org/obo/GO_0048513)
+
+#### Added
+- [esophagus development](http://purl.obolibrary.org/obo/GO_1903702) SubClassOf [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856)
+
+
+### establishment of localization `http://purl.obolibrary.org/obo/GO_0051234`
+
+#### Added
+- [establishment of localization](http://purl.obolibrary.org/obo/GO_0051234) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+
+- [establishment of localization](http://purl.obolibrary.org/obo/GO_0051234) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/24200"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### estrogen receptor `http://purl.obolibrary.org/obo/PR_000007204`
+
+#### Added
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000007204"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nuclear receptor subfamily 3 group A member 1"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=gene."
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER-alpha"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ESR"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372)
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPHARobj:620"
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Estra"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ESR1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
-### endocrine cell `http://purl.obolibrary.org/obo/CL_0000163`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "estradiol receptor"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NR3A1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A protein that is a translation product of the human ESR1 gene or a 1:1 ortholog thereof."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [label](http://www.w3.org/2000/01/rdf-schema#label) "estrogen receptor"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER"
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Estr"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- Class: [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204)
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) SubClassOf [protein](http://purl.obolibrary.org/obo/PR_000000001)
+
+- [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) SubClassOf [CHEBI_36080](http://purl.obolibrary.org/obo/CHEBI_36080)
+
+
+### estrogen receptor (human) `http://purl.obolibrary.org/obo/PR_P03372`
+
+#### Added
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DTO:00117511"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "estradiol receptor (human)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ESR1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An estrogen receptor that is encoded in the genome of human."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER (human)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NR3A1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9020968"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "PR:P03372 located_in GO:0005829"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "hESR1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER-alpha (human)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-446168"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "PR:P03372 located_in GO:0005654"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ESR"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [label](http://www.w3.org/2000/01/rdf-schema#label) "estrogen receptor (human)"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=organism-gene."
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nuclear receptor subfamily 3 group A member 1 (human)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P03372"
+
+- Class: [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372)
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) EquivalentTo [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606))
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) SubClassOf [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204)
+
+- [estrogen receptor (human)](http://purl.obolibrary.org/obo/PR_P03372) SubClassOf [Homo sapiens protein](http://purl.obolibrary.org/obo/PR_000029067)
+
+
+### estrogen receptor (mouse) `http://purl.obolibrary.org/obo/PR_P19785`
+
+#### Added
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER-alpha (mouse)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=organism-gene."
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "mESR1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER (mouse)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Estra"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Esr"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nuclear receptor subfamily 3 group A member 1 (mouse)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "estradiol receptor (mouse)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An estrogen receptor that is encoded in the genome of mouse."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OMA:P19785"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [label](http://www.w3.org/2000/01/rdf-schema#label) "estrogen receptor (mouse)"
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Esr1"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Nr3a1"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Estr"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P19785"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:P19785"
+
+- Class: [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) EquivalentTo [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Mus musculus](http://purl.obolibrary.org/obo/NCBITaxon_10090))
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) SubClassOf [Mus musculus protein](http://purl.obolibrary.org/obo/PR_000029032)
+
+- [estrogen receptor (mouse)](http://purl.obolibrary.org/obo/PR_P19785) SubClassOf [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204)
+
+
+### exhausted T cell differentiation `http://purl.obolibrary.org/obo/GO_0160083`
+
+#### Added
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "T cell exhaustion"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [label](http://www.w3.org/2000/01/rdf-schema#label) "exhausted T cell differentiation"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which an activated T cell acquires specialized features of an exhausted T cell."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31570879"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21739672"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0160083"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25698"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2023-07-14T22:56:05Z"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rynl"
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "T cell dysfuction"
+
+- Class: [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083)
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) EquivalentTo [cell differentiation](http://purl.obolibrary.org/obo/GO_0030154) and ([results in acquisition of features of](http://purl.obolibrary.org/obo/RO_0002315) some [exhausted T cell](http://purl.obolibrary.org/obo/CL_0011025))
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) SubClassOf [results in acquisition of features of](http://purl.obolibrary.org/obo/RO_0002315) some [exhausted T cell](http://purl.obolibrary.org/obo/CL_0011025)
+
+- [exhausted T cell differentiation](http://purl.obolibrary.org/obo/GO_0160083) SubClassOf [T cell differentiation](http://purl.obolibrary.org/obo/GO_0030217)
+
+
+### extraembryonic structure `http://purl.obolibrary.org/obo/CARO_0000042`
#### Removed
-- [endocrine cell](http://purl.obolibrary.org/obo/CL_0000163) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some
-([hormone secretion](http://purl.obolibrary.org/obo/GO_0046879) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [circulatory system](http://purl.obolibrary.org/obo/UBERON_0001009))))
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "MH: define as not part of embryo, or will not develop into embryo? MH: changed def to exclude cells so this class could be included in gross anatomical part. DOS: Changed to something that I think works for both vertebrates and invertebrates and that keeps the restriction to multicellular structures. Old def: "Anatomical structure that is contiguous with the embryo and is comprised of portions of tissue that will not contribute to the embryo.". One remaining question - perhaps zygote is too restrictive given that some organisms have parthenogenesis e.g. aphids?
+"
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis."
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000042"
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) [label](http://www.w3.org/2000/01/rdf-schema#label) "extraembryonic structure"
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [plus](http://purl.obolibrary.org/obo/caro#plus)
+
+- Class: [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042)
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) DisjointWith [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000)
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) DisjointWith [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) SubClassOf [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008)
+
+- [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [endocrine cell](http://purl.obolibrary.org/obo/CL_0000163) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+
+
+### fallopian tube ciliated cell `http://purl.obolibrary.org/obo/CL_4030007`
+
+#### Added
+- [fallopian tube ciliated cell](http://purl.obolibrary.org/obo/CL_4030007) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [fallopian tube ciliated cell](http://purl.obolibrary.org/obo/CL_4030007) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### fallopian tube secretory epithelial cell `http://purl.obolibrary.org/obo/CL_4030006`
#### Added
-- [endocrine cell](http://purl.obolibrary.org/obo/CL_0000163) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some
-([hormone secretion](http://purl.obolibrary.org/obo/GO_0046879) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [circulatory system](http://purl.obolibrary.org/obo/UBERON_0001009))))
+- [fallopian tube secretory epithelial cell](http://purl.obolibrary.org/obo/CL_4030006) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [fallopian tube secretory epithelial cell](http://purl.obolibrary.org/obo/CL_4030006) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### endocrine system `http://purl.obolibrary.org/obo/UBERON_0000949`
+### fasciculates with `http://purl.obolibrary.org/obo/RO_0002101`
#### Removed
-- [endocrine system](http://purl.obolibrary.org/obo/UBERON_0000949) EquivalentTo [non-connected functional system](http://purl.obolibrary.org/obo/UBERON_0015203) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [endocrine process](http://purl.obolibrary.org/obo/GO_0050886))
+- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
+
+- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0002101"
+
+- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) [id](http://www.geneontology.org/formats/oboInOwl#id) "fasciculates_with"
+
+
+
+### fibroblast of lung `http://purl.obolibrary.org/obo/CL_0002553`
+#### Removed
+- [fibroblast of lung](http://purl.obolibrary.org/obo/CL_0002553) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [fibroblast of lung](http://purl.obolibrary.org/obo/CL_0002553) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [endocrine system](http://purl.obolibrary.org/obo/UBERON_0000949) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [endocrine process](http://purl.obolibrary.org/obo/GO_0050886)
+### fibroblast of pulmonary artery `http://purl.obolibrary.org/obo/CL_0002557`
-### enteroglial cell `http://purl.obolibrary.org/obo/CL_4040002`
+#### Added
+- [fibroblast of pulmonary artery](http://purl.obolibrary.org/obo/CL_0002557) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [fibroblast of pulmonary artery](http://purl.obolibrary.org/obo/CL_0002557) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### fibroblast of villous mesenchyme `http://purl.obolibrary.org/obo/CL_0002558`
+
+#### Added
+- [fibroblast of villous mesenchyme](http://purl.obolibrary.org/obo/CL_0002558) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [fibroblast of villous mesenchyme](http://purl.obolibrary.org/obo/CL_0002558) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+
+### flat midget bipolar cell `http://purl.obolibrary.org/obo/CL_4033033`
#### Removed
-- [enteroglial cell](http://purl.obolibrary.org/obo/CL_4040002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "enteric glia"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11169131"
+- [flat midget bipolar cell](http://purl.obolibrary.org/obo/CL_4033033) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FMB cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
#### Added
-- [enteroglial cell](http://purl.obolibrary.org/obo/CL_4040002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "enteric glia"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11169131"
+- [flat midget bipolar cell](http://purl.obolibrary.org/obo/CL_4033033) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FMB cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+
+### folliculostellate cell `http://purl.obolibrary.org/obo/CL_0000642`
+#### Removed
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006"
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FS cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### epidermal cell (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000463`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454"
#### Added
-- [epidermal cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000463) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006"
-### epididymal lumen `http://purl.obolibrary.org/obo/UBERON_0035956`
-#### Removed
-- [epididymal lumen](http://purl.obolibrary.org/obo/UBERON_0035956) SubClassOf [contains](http://purl.obolibrary.org/obo/RO_0001019) some [seminal fluid](http://purl.obolibrary.org/obo/UBERON_0006530)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FS cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [epididymal lumen](http://purl.obolibrary.org/obo/UBERON_0035956) SubClassOf [location of](http://purl.obolibrary.org/obo/RO_0001015) some [seminal fluid](http://purl.obolibrary.org/obo/UBERON_0006530)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454"
-### epithelial cell `http://purl.obolibrary.org/obo/CL_0000066`
+### gamma-delta T cell `http://purl.obolibrary.org/obo/CL_0000798`
#### Removed
-- [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [gamma-delta T cell](http://purl.obolibrary.org/obo/CL_0000798) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gd T cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [gamma-delta T cell](http://purl.obolibrary.org/obo/CL_0000798) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gd T cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### epithelial cell of amnion `http://purl.obolibrary.org/obo/CL_0002536`
+### giant bipolar cell `http://purl.obolibrary.org/obo/CL_4033035`
#### Removed
-- [epithelial cell of amnion](http://purl.obolibrary.org/obo/CL_0002536) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [giant bipolar cell](http://purl.obolibrary.org/obo/CL_4033035) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GB cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [epithelial cell of amnion](http://purl.obolibrary.org/obo/CL_0002536) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
#### Added
-- [epithelial cell of amnion](http://purl.obolibrary.org/obo/CL_0002536) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [giant bipolar cell](http://purl.obolibrary.org/obo/CL_4033035) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GB cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### epithelial cell of cervix `http://purl.obolibrary.org/obo/CL_0002535`
-#### Removed
-- [epithelial cell of cervix](http://purl.obolibrary.org/obo/CL_0002535) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
-- [epithelial cell of cervix](http://purl.obolibrary.org/obo/CL_0002535) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### glial cell `http://purl.obolibrary.org/obo/CL_0000125`
#### Added
-- [epithelial cell of cervix](http://purl.obolibrary.org/obo/CL_0002535) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [glial cell](http://purl.obolibrary.org/obo/CL_0000125) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [glial cell](http://purl.obolibrary.org/obo/CL_0000125) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### epithelial cell of external acoustic meatus `http://purl.obolibrary.org/obo/CL_1000434`
+
+### glial restricted tripotential precursor cell `http://purl.obolibrary.org/obo/CL_4040000`
#### Removed
-- [epithelial cell of external acoustic meatus](http://purl.obolibrary.org/obo/CL_1000434) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [glial restricted tripotential precursor cell](http://purl.obolibrary.org/obo/CL_4040000) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GRP cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [epithelial cell of external acoustic meatus](http://purl.obolibrary.org/obo/CL_1000434) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11756508"
#### Added
-- [epithelial cell of external acoustic meatus](http://purl.obolibrary.org/obo/CL_1000434) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [glial restricted tripotential precursor cell](http://purl.obolibrary.org/obo/CL_4040000) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GRP cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11756508"
-### epithelial cell of gallbladder `http://purl.obolibrary.org/obo/CL_1000415`
+### globular bushy cell `http://purl.obolibrary.org/obo/CL_4023164`
#### Removed
-- [epithelial cell of gallbladder](http://purl.obolibrary.org/obo/CL_1000415) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [globular bushy cell](http://purl.obolibrary.org/obo/CL_4023164) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "GBC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [epithelial cell of gallbladder](http://purl.obolibrary.org/obo/CL_1000415) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31881018"
#### Added
-- [epithelial cell of gallbladder](http://purl.obolibrary.org/obo/CL_1000415) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [globular bushy cell](http://purl.obolibrary.org/obo/CL_4023164) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "GBC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31881018"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### epithelial cell of lacrimal canaliculus `http://purl.obolibrary.org/obo/CL_1000433`
-#### Removed
-- [epithelial cell of lacrimal canaliculus](http://purl.obolibrary.org/obo/CL_1000433) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
-- [epithelial cell of lacrimal canaliculus](http://purl.obolibrary.org/obo/CL_1000433) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+### glutamate-gated calcium ion channel activity `http://purl.obolibrary.org/obo/GO_0022849`
#### Added
-- [epithelial cell of lacrimal canaliculus](http://purl.obolibrary.org/obo/CL_1000433) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0022849"
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-### epithelial cell of pancreas `http://purl.obolibrary.org/obo/CL_0000083`
-#### Removed
-- [epithelial cell of pancreas](http://purl.obolibrary.org/obo/CL_0000083) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0815340729"
-- [epithelial cell of pancreas](http://purl.obolibrary.org/obo/CL_0000083) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_transport"
-#### Added
-- [epithelial cell of pancreas](http://purl.obolibrary.org/obo/CL_0000083) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) [label](http://www.w3.org/2000/01/rdf-schema#label) "glutamate-gated calcium ion channel activity"
+- Class: [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849)
-### epithelial cell of urethra `http://purl.obolibrary.org/obo/CL_1000296`
-#### Removed
-- [epithelial cell of urethra](http://purl.obolibrary.org/obo/CL_1000296) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_14321](http://purl.obolibrary.org/obo/CHEBI_14321))
-- [epithelial cell of urethra](http://purl.obolibrary.org/obo/CL_1000296) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) SubClassOf [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970)
-#### Added
-- [epithelial cell of urethra](http://purl.obolibrary.org/obo/CL_1000296) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [glutamate-gated calcium ion channel activity](http://purl.obolibrary.org/obo/GO_0022849) SubClassOf [ligand-gated calcium channel activity](http://purl.obolibrary.org/obo/GO_0099604)
-### epithelial cell of viscerocranial mucosa `http://purl.obolibrary.org/obo/CL_1000441`
+### granulocyte monocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0000557`
#### Removed
-- [epithelial cell of viscerocranial mucosa](http://purl.obolibrary.org/obo/CL_1000441) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464"
-### erythrophore `http://purl.obolibrary.org/obo/CL_0000574`
-#### Removed
-- [erythrophore](http://purl.obolibrary.org/obo/CL_0000574) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186"
+- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021"
-### eukaryotic cell `http://purl.obolibrary.org/obo/CL_0000255`
-#### Removed
-- [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464"
-- [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186"
#### Added
-- [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759))
+- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GM"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021"
-- [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### example to be eventually removed `http://purl.obolibrary.org/obo/IAO_0000002`
-
-#### Added
-- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "example to be eventually removed"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186"
-- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [label](http://www.w3.org/2000/01/rdf-schema#label) "example to be eventually removed"@en
+- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021"
-- Individual: [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### exocrine cell `http://purl.obolibrary.org/obo/CL_0000152`
-#### Removed
-- [exocrine cell](http://purl.obolibrary.org/obo/CL_0000152) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186"
+### gross anatomical part `http://purl.obolibrary.org/obo/CARO_0001008`
+#### Removed
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
-### expand expression to `http://purl.obolibrary.org/obo/IAO_0000424`
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) [label](http://www.w3.org/2000/01/rdf-schema#label) "gross anatomical part"@en
-#### Added
-- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "ObjectProperty: RO_0002104
-Label: has plasma membrane part
-Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
-"@en
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-9114-8737](https://orcid.org/0000-0001-9114-8737)
-- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [label](http://www.w3.org/2000/01/rdf-schema#label) "expand expression to"@en
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) [IAO_creation_date](http://purl.obolibrary.org/obo/IAO_creation_date) "10.7.2011"
-- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Chris Mungall"@en
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [plus](http://purl.obolibrary.org/obo/caro#plus)
-- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "expand expression to"@en
+- Class: [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008)
-- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) EquivalentTo [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) or [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) or [acellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0000040) or [extraembryonic structure](http://purl.obolibrary.org/obo/CARO_0000042) or [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) or [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012)
-### external cervical os `http://purl.obolibrary.org/obo/UBERON_0013760`
+- [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [external cervical os](http://purl.obolibrary.org/obo/UBERON_0013760) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Uterus.glb"
-### external iliac vein `http://purl.obolibrary.org/obo/UBERON_0001316`
+### haploid cell `http://purl.obolibrary.org/obo/CL_0000413`
#### Added
-- [external iliac vein](http://purl.obolibrary.org/obo/UBERON_0001316) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-
+- [haploid cell](http://purl.obolibrary.org/obo/CL_0000413) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### extraembryonic cell `http://purl.obolibrary.org/obo/CL_0000349`
-#### Removed
-- [extraembryonic cell](http://purl.obolibrary.org/obo/CL_0000349) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [extraembryonic structure](http://purl.obolibrary.org/obo/UBERON_0000478))
+- [haploid cell](http://purl.obolibrary.org/obo/CL_0000413) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [extraembryonic cell](http://purl.obolibrary.org/obo/CL_0000349) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
-#### Added
-- [extraembryonic cell](http://purl.obolibrary.org/obo/CL_0000349) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [extraembryonic structure](http://purl.obolibrary.org/obo/UBERON_0000478))
+### has postsynaptic terminal in `http://purl.obolibrary.org/obo/RO_0002110`
+#### Removed
+- [has postsynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002110) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Relation between a neuron and the structure in which its dendrite receives synapses."
-- [extraembryonic cell](http://purl.obolibrary.org/obo/CL_0000349) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [has postsynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002110) [id](http://www.geneontology.org/formats/oboInOwl#id) "has_postsynaptic_terminals_in"
+- [has postsynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002110) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
-### eye trabecular meshwork `http://purl.obolibrary.org/obo/UBERON_0005969`
+- [has postsynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002110) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0002110"
-#### Added
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb"
+- [has postsynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002110) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-l.glb"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_R.glb"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-l.glb"
+### has presynaptic terminal in `http://purl.obolibrary.org/obo/RO_0002113`
+#### Removed
+- [has presynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002113) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0002113"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-r.glb"
+- [has presynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002113) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb"
+- [has presynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002113) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-r.glb"
+- [has presynaptic terminal in](http://purl.obolibrary.org/obo/RO_0002113) [id](http://www.geneontology.org/formats/oboInOwl#id) "has_presynaptic_terminals_in"
-- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb"
-### failed exploratory term `http://purl.obolibrary.org/obo/IAO_0000103`
+### has small molecule activator `http://purl.obolibrary.org/obo/RO_0012001`
#### Added
-- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [label](http://www.w3.org/2000/01/rdf-schema#label) "failed exploratory term"@en
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [label](http://www.w3.org/2000/01/rdf-schema#label) "has small molecule activator"@en
-- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
-- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "failed exploratory term"@en
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2020-04-22T20:28:37Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "external"
-- Individual: [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103)
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [label](http://www.w3.org/2000/01/rdf-schema#label) "has small molecule activator"
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
-### falciform ligament `http://purl.obolibrary.org/obo/UBERON_0001247`
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [shorthand](http://www.geneontology.org/formats/oboInOwl#shorthand) "has_small_molecule_activator"
-#### Added
-- [falciform ligament](http://purl.obolibrary.org/obo/UBERON_0001247) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb"
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0012001"
-- [falciform ligament](http://purl.obolibrary.org/obo/UBERON_0001247) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb"
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) [id](http://www.geneontology.org/formats/oboInOwl#id) "has_small_molecule_activator"
+- ObjectProperty: [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001)
-### fat body cell `http://purl.obolibrary.org/obo/CL_0000565`
-#### Removed
-- [fat body cell](http://purl.obolibrary.org/obo/CL_0000565) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) InverseOf [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005)
+- [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) SubPropertyOf: [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000)
-### fenestrated cell `http://purl.obolibrary.org/obo/CL_0000666`
-#### Removed
-- [fenestrated cell](http://purl.obolibrary.org/obo/CL_0000666) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### has small molecule regulator `http://purl.obolibrary.org/obo/RO_0012000`
+#### Added
+- [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
+- [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000) [label](http://www.w3.org/2000/01/rdf-schema#label) "has small molecule regulator"@en
-### fetal hepatobiliary progenitor cell `http://purl.obolibrary.org/obo/CL_0009013`
-#### Removed
-- [fetal hepatobiliary progenitor cell](http://purl.obolibrary.org/obo/CL_0009013) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+- [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2020-04-22T20:27:26Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- ObjectProperty: [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000)
-### flag A amacrine cell `http://purl.obolibrary.org/obo/CL_0004221`
-#### Removed
-- [flag A amacrine cell](http://purl.obolibrary.org/obo/CL_0004221) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A flag amacrine cell with post-synaptic terminals in S2 and S3."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000) InverseOf [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004)
-#### Added
-- [flag A amacrine cell](http://purl.obolibrary.org/obo/CL_0004221) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A flag amacrine cell with post-synaptic terminals in S2 and S3. This cell type releases the neurotransmitter glycine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [has small molecule regulator](http://purl.obolibrary.org/obo/RO_0012000) SubPropertyOf: [has participant](http://purl.obolibrary.org/obo/RO_0000057)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24246263"
-- [flag A amacrine cell](http://purl.obolibrary.org/obo/CL_0004221) SubClassOf [glycinergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030028)
+### has soma location `http://purl.obolibrary.org/obo/RO_0002100`
+#### Removed
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [id](http://www.geneontology.org/formats/oboInOwl#id) "has_soma_location"
-### flag B amacrine cell `http://purl.obolibrary.org/obo/CL_0004222`
-#### Removed
-- [flag B amacrine cell](http://purl.obolibrary.org/obo/CL_0004222) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A flag amacrine cell with post-synaptic terminals in S3, S4, and S5."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
-#### Added
-- [flag B amacrine cell](http://purl.obolibrary.org/obo/CL_0004222) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A flag amacrine cell with post-synaptic terminals in S3, S4, and S5. This cell type releases the neurotransmitter glycine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0002100"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24246263"
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and an anatomical structure that its soma is part of."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [flag B amacrine cell](http://purl.obolibrary.org/obo/CL_0004222) SubClassOf [glycinergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030028)
-### flag amacrine cell `http://purl.obolibrary.org/obo/CL_0004220`
+### has synaptic terminal in `http://purl.obolibrary.org/obo/RO_0002130`
#### Removed
-- [flag amacrine cell](http://purl.obolibrary.org/obo/CL_0004220) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [has synaptic terminal in](http://purl.obolibrary.org/obo/RO_0002130) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)"
-#### Added
-- [flag amacrine cell](http://purl.obolibrary.org/obo/CL_0004220) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+- [has synaptic terminal in](http://purl.obolibrary.org/obo/RO_0002130) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+- [has synaptic terminal in](http://purl.obolibrary.org/obo/RO_0002130) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
-### flask cell `http://purl.obolibrary.org/obo/CL_0007023`
-#### Removed
-- [flask cell](http://purl.obolibrary.org/obo/CL_0007023) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [has synaptic terminal in](http://purl.obolibrary.org/obo/RO_0002130) [id](http://www.geneontology.org/formats/oboInOwl#id) "has_synaptic_terminals_in"
-#### Added
-- [flask cell](http://purl.obolibrary.org/obo/CL_0007023) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [has synaptic terminal in](http://purl.obolibrary.org/obo/RO_0002130) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
+- [has synaptic terminal in](http://purl.obolibrary.org/obo/RO_0002130) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0002130"
-### flat bistratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004227`
-#### Removed
-- [flat bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004227) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
-#### Added
-- [flat bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004227) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A bistratified amacrine cell with a small dendritic field. Flat bistratified amacrine cells have post-synaptic terminals both on the border of S1 and S2, and on the border of S3 and S4. This cell type releases the neurotransmitter glycine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25630271"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+### has_boundary `http://purl.obolibrary.org/obo/RO_0002002`
+#### Removed
+- [has_boundary](http://purl.obolibrary.org/obo/RO_0002002) [label](http://www.w3.org/2000/01/rdf-schema#label) "has_boundary"@en
+
+- [has_boundary](http://purl.obolibrary.org/obo/RO_0002002) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [flat bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004227) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+- [has_boundary](http://purl.obolibrary.org/obo/RO_0002002) Range [anatomical boundary](http://purl.obolibrary.org/obo/CARO_0000010)
-- [flat bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004227) SubClassOf [glycinergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030028)
-### foam cell `http://purl.obolibrary.org/obo/CL_0000891`
+### hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0000037`
#### Removed
-- [foam cell](http://purl.obolibrary.org/obo/CL_0000891) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0000037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [foam cell](http://purl.obolibrary.org/obo/CL_0000891) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0000037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### follicle cell of egg chamber `http://purl.obolibrary.org/obo/CL_0000477`
+### hepatic portal fibroblast `http://purl.obolibrary.org/obo/CL_0009100`
#### Added
-- [follicle cell of egg chamber](http://purl.obolibrary.org/obo/CL_0000477) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [hepatic portal fibroblast](http://purl.obolibrary.org/obo/CL_0009100) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [hepatic portal fibroblast](http://purl.obolibrary.org/obo/CL_0009100) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### follicle stem cell (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000441`
+### hepatic stem cell `http://purl.obolibrary.org/obo/CL_0002195`
+#### Removed
+- [hepatic stem cell](http://purl.obolibrary.org/obo/CL_0002195) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HpSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18442648"
#### Added
-- [follicle stem cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000441) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [hepatic stem cell](http://purl.obolibrary.org/obo/CL_0002195) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HpSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18442648"
-### follicular dendritic cell `http://purl.obolibrary.org/obo/CL_0000442`
+### heterocyclic compound binding `http://purl.obolibrary.org/obo/GO_1901363`
#### Removed
-- [follicular dendritic cell](http://purl.obolibrary.org/obo/CL_0000442) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [heterocyclic compound binding](http://purl.obolibrary.org/obo/GO_1901363) EquivalentTo [binding](http://purl.obolibrary.org/obo/GO_0005488) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686))
+- [heterocyclic compound binding](http://purl.obolibrary.org/obo/GO_1901363) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
+#### Added
+- [heterocyclic compound binding](http://purl.obolibrary.org/obo/GO_1901363) EquivalentTo [small molecule binding](http://purl.obolibrary.org/obo/GO_0036094) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_5686](http://purl.obolibrary.org/obo/CHEBI_5686))
-### follicular epithelial cell `http://purl.obolibrary.org/obo/CL_0000500`
-#### Removed
-- [follicular epithelial cell](http://purl.obolibrary.org/obo/CL_0000500) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [heterocyclic compound binding](http://purl.obolibrary.org/obo/GO_1901363) SubClassOf [small molecule binding](http://purl.obolibrary.org/obo/GO_0036094)
+### hippocampal mossy fiber `http://purl.obolibrary.org/obo/GO_0097457`
+#### Removed
+- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:nlx_subcell_100312"
-### fornix of brain `http://purl.obolibrary.org/obo/UBERON_0000052`
+- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) SubClassOf [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302)
#### Added
-- [fornix of brain](http://purl.obolibrary.org/obo/UBERON_0000052) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709"
-- [fornix of brain](http://purl.obolibrary.org/obo/UBERON_0000052) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24336151"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:nlx_subcell_100312"
-### fountain amacrine cell `http://purl.obolibrary.org/obo/CL_0004237`
-#### Removed
-- [fountain amacrine cell](http://purl.obolibrary.org/obo/CL_0004237) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20554881"
-- [fountain amacrine cell](http://purl.obolibrary.org/obo/CL_0004237) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25796"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-#### Added
-- [fountain amacrine cell](http://purl.obolibrary.org/obo/CL_0004237) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4. This cell type releases the neurotransmitter gamma-aminobutyric acid (GABA)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [hippocampal granule cell](http://purl.obolibrary.org/obo/CL_0001033)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10614594"
+- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) SubClassOf [axon](http://purl.obolibrary.org/obo/GO_0030424)
-- [fountain amacrine cell](http://purl.obolibrary.org/obo/CL_0004237) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
-- [fountain amacrine cell](http://purl.obolibrary.org/obo/CL_0004237) SubClassOf [GABAergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030027)
+### histamine catabolic process `http://purl.obolibrary.org/obo/GO_0001695`
+#### Removed
+- [histamine catabolic process](http://purl.obolibrary.org/obo/GO_0001695) SubClassOf [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135)
+
-### fourth ventricle `http://purl.obolibrary.org/obo/UBERON_0002422`
+### hypertrophic chondrocyte `http://purl.obolibrary.org/obo/CL_0000743`
#### Added
-- [fourth ventricle](http://purl.obolibrary.org/obo/UBERON_0002422) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [hypertrophic chondrocyte](http://purl.obolibrary.org/obo/CL_0000743) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [fourth ventricle](http://purl.obolibrary.org/obo/UBERON_0002422) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [hypertrophic chondrocyte](http://purl.obolibrary.org/obo/CL_0000743) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### fundus of urinary bladder `http://purl.obolibrary.org/obo/UBERON_0006082`
+### ice binding `http://purl.obolibrary.org/obo/GO_0050825`
#### Added
-- [fundus of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0006082) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urinary_Bladder.glb"
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ice nucleation inhibitor activity"
-- [fundus of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0006082) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Urinary_Bladder.glb"
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators"
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-### fungal cell `http://purl.obolibrary.org/obo/CL_0000521`
-#### Removed
-- [fungal cell](http://purl.obolibrary.org/obo/CL_0000521) DisjointWith [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-- [fungal cell](http://purl.obolibrary.org/obo/CL_0000521) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ice crystal binding"
-#### Added
-- [fungal cell](http://purl.obolibrary.org/obo/CL_0000521) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [label](http://www.w3.org/2000/01/rdf-schema#label) "ice binding"
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0050825"
-### gamete-nursing cell `http://purl.obolibrary.org/obo/CL_4029001`
-#### Removed
-- [gamete-nursing cell](http://purl.obolibrary.org/obo/CL_4029001) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ice nucleation activity"
-#### Added
-- [gamete-nursing cell](http://purl.obolibrary.org/obo/CL_4029001) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "antifreeze activity"
+- Class: [ice binding](http://purl.obolibrary.org/obo/GO_0050825)
-### germ line cell `http://purl.obolibrary.org/obo/CL_0000039`
-#### Removed
-- [germ line cell](http://purl.obolibrary.org/obo/CL_0000039) DisjointWith [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) EquivalentTo [small molecule binding](http://purl.obolibrary.org/obo/GO_0036094) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_15377](http://purl.obolibrary.org/obo/CHEBI_15377))
-- [germ line cell](http://purl.obolibrary.org/obo/CL_0000039) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) SubClassOf [small molecule binding](http://purl.obolibrary.org/obo/GO_0036094)
-#### Added
-- [germ line cell](http://purl.obolibrary.org/obo/CL_0000039) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [ice binding](http://purl.obolibrary.org/obo/GO_0050825) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_15377](http://purl.obolibrary.org/obo/CHEBI_15377)
-### germ line stem cell `http://purl.obolibrary.org/obo/CL_0000014`
+### imaginal disc morphogenesis `http://purl.obolibrary.org/obo/GO_0007560`
#### Removed
-- [germ line stem cell](http://purl.obolibrary.org/obo/CL_0000014) SubClassOf [germ line cell](http://purl.obolibrary.org/obo/CL_0000039)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [imaginal disc morphogenesis](http://purl.obolibrary.org/obo/GO_0007560) SubClassOf [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563)
#### Added
-- [germ line stem cell](http://purl.obolibrary.org/obo/CL_0000014) SubClassOf [germ line cell](http://purl.obolibrary.org/obo/CL_0000039)
+- [imaginal disc morphogenesis](http://purl.obolibrary.org/obo/GO_0007560) SubClassOf [animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0009887)
-### germinal center `http://purl.obolibrary.org/obo/UBERON_0010754`
+### immaterial anatomical entity `http://purl.obolibrary.org/obo/CARO_0000007`
#### Removed
-- [germinal center](http://purl.obolibrary.org/obo/UBERON_0010754) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anatomical entity that has no mass."
-- [germinal center](http://purl.obolibrary.org/obo/UBERON_0010754) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000007"
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) [label](http://www.w3.org/2000/01/rdf-schema#label) "immaterial anatomical entity"
-### germline-derived nurse cell `http://purl.obolibrary.org/obo/CL_4029002`
-#### Removed
-- [germline-derived nurse cell](http://purl.obolibrary.org/obo/CL_4029002) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- Class: [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) DisjointWith [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) EquivalentTo [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) and (not ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mass](http://purl.obolibrary.org/obo/PATO_0000125)))
-### glandular epithelial cell `http://purl.obolibrary.org/obo/CL_0000150`
-#### Removed
-- [glandular epithelial cell](http://purl.obolibrary.org/obo/CL_0000150) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) SubClassOf [immaterial entity](http://purl.obolibrary.org/obo/BFO_0000141)
+- [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### glioblast `http://purl.obolibrary.org/obo/CL_0000030`
-#### Removed
-- [glioblast](http://purl.obolibrary.org/obo/CL_0000030) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+### immunoglobulin binding `http://purl.obolibrary.org/obo/GO_0019865`
+#### Added
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019865"
-### gut absorptive cell `http://purl.obolibrary.org/obo/CL_0000677`
-#### Removed
-- [gut absorptive cell](http://purl.obolibrary.org/obo/CL_0000677) SubClassOf [absorptive cell](http://purl.obolibrary.org/obo/CL_0000212)
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to an immunoglobulin."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ma"
-#### Added
-- [gut absorptive cell](http://purl.obolibrary.org/obo/CL_0000677) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) [label](http://www.w3.org/2000/01/rdf-schema#label) "immunoglobulin binding"
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-### hair follicle cell `http://purl.obolibrary.org/obo/CL_0002559`
-#### Removed
-- [hair follicle cell](http://purl.obolibrary.org/obo/CL_0002559) EquivalentTo [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [hair follicle](http://purl.obolibrary.org/obo/UBERON_0002073))
+- Class: [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865)
-- [hair follicle cell](http://purl.obolibrary.org/obo/CL_0002559) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) EquivalentTo [binding](http://purl.obolibrary.org/obo/GO_0005488) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [immunoglobulin complex](http://purl.obolibrary.org/obo/GO_0019814))
-#### Added
-- [hair follicle cell](http://purl.obolibrary.org/obo/CL_0002559) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [hair follicle](http://purl.obolibrary.org/obo/UBERON_0002073))
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [immunoglobulin complex](http://purl.obolibrary.org/obo/GO_0019814)
-- [hair follicle cell](http://purl.obolibrary.org/obo/CL_0002559) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [immunoglobulin binding](http://purl.obolibrary.org/obo/GO_0019865) SubClassOf [protein-containing complex binding](http://purl.obolibrary.org/obo/GO_0044877)
-### haploid cell `http://purl.obolibrary.org/obo/CL_0000413`
+### increased mass `http://purl.obolibrary.org/obo/PATO_0001563`
#### Removed
-- [haploid cell](http://purl.obolibrary.org/obo/CL_0000413) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [haploid](http://purl.obolibrary.org/obo/PATO_0001375))
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [id](http://www.geneontology.org/formats/oboInOwl#id) "PATO:0001563"
-- [haploid cell](http://purl.obolibrary.org/obo/CL_0000413) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [RO_0002604](http://purl.obolibrary.org/obo/RO_0002604) [decreased mass](http://purl.obolibrary.org/obo/PATO_0001562)
-#### Added
-- [haploid cell](http://purl.obolibrary.org/obo/CL_0000413) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [haploid](http://purl.obolibrary.org/obo/PATO_0001375))
-
-- [haploid cell](http://purl.obolibrary.org/obo/CL_0000413) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "large mass"
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "high mass"
-### has obsolescence reason `http://purl.obolibrary.org/obo/IAO_0000231`
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [label](http://www.w3.org/2000/01/rdf-schema#label) "increased mass"
-#### Added
-- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has obsolescence reason"@en
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "quality"
-- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [label](http://www.w3.org/2000/01/rdf-schema#label) "has obsolescence reason"@en
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [value_slim](http://purl.obolibrary.org/obo/pato#value_slim)
-- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Alan Ruttenberg"@en
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A mass which is higher than normal or average."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PATO:GVG"
-- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "PATO:0000578"
-- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Melanie Courtot"@en
+- Class: [increased mass](http://purl.obolibrary.org/obo/PATO_0001563)
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) EquivalentTo [mass](http://purl.obolibrary.org/obo/PATO_0000125) and ([increased in magnitude relative to](http://purl.obolibrary.org/obo/RO_0015007) some [normal](http://purl.obolibrary.org/obo/PATO_0000461))
-### has_broad_synonym `http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym`
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) SubClassOf [increased object quality](http://purl.obolibrary.org/obo/PATO_0002305)
-#### Added
-- [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/information-artifact-ontology/ontology-metadata/issues/18"
+- [increased mass](http://purl.obolibrary.org/obo/PATO_0001563) SubClassOf [mass](http://purl.obolibrary.org/obo/PATO_0000125)
-- [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/information-artifact-ontology/ontology-metadata/issues/18"
-- [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) [label](http://www.w3.org/2000/01/rdf-schema#label) "has broad synonym"@en
-- [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-5208-3432](http://orcid.org/0000-0001-5208-3432)
+### indirect pathway medium spiny neuron `http://purl.obolibrary.org/obo/CL_4023029`
+#### Removed
+- [indirect pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023029) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "D2-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An alternative label for a class or property which has a more general meaning than the preferred name/primary label."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34727523"
+- [indirect pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023029) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "iSPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### has_exact_synonym `http://www.geneontology.org/formats/oboInOwl#hasExactSynonym`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096299"
#### Added
-- [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An alternative label for a class or property which has the exact same meaning than the preferred name/primary label."
-
-- [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/information-artifact-ontology/ontology-metadata/issues/20"
+- [indirect pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023029) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "iSPN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096299"
-- [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-5208-3432](http://orcid.org/0000-0001-5208-3432)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) [label](http://www.w3.org/2000/01/rdf-schema#label) "has exact synonym"@en
+- [indirect pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023029) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "D2-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/information-artifact-ontology/ontology-metadata/issues/20"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34727523"
-### has_narrow_synonym `http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym`
-
-#### Added
-- [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-5208-3432](http://orcid.org/0000-0001-5208-3432)
-
-- [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) [label](http://www.w3.org/2000/01/rdf-schema#label) "has narrow synonym"@en
+### innervates `http://purl.obolibrary.org/obo/RO_0002134`
+#### Removed
+- [innervates](http://purl.obolibrary.org/obo/RO_0002134) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
-- [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/information-artifact-ontology/ontology-metadata/issues/19"
+- [innervates](http://purl.obolibrary.org/obo/RO_0002134) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An alternative label for a class or property which has a more specific meaning than the preferred name/primary label."
+- [innervates](http://purl.obolibrary.org/obo/RO_0002134) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
-- [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/information-artifact-ontology/ontology-metadata/issues/19"
-### has_related_synonym `http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym`
+### intermediate cell of urothelium `http://purl.obolibrary.org/obo/CL_4030055`
#### Added
-- [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-5208-3432](http://orcid.org/0000-0001-5208-3432)
+- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/information-artifact-ontology/ontology-metadata/issues/21"
+- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) [label](http://www.w3.org/2000/01/rdf-schema#label) "has related synonym"@en
-- [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct."
+### intermediate filament binding `http://purl.obolibrary.org/obo/GO_0019215`
+#### Removed
+- [intermediate filament binding](http://purl.obolibrary.org/obo/GO_0019215) SubClassOf [protein-containing complex binding](http://purl.obolibrary.org/obo/GO_0044877)
-- [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/information-artifact-ontology/ontology-metadata/issues/21"
+#### Added
+- [intermediate filament binding](http://purl.obolibrary.org/obo/GO_0019215) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
-### hatching gland cell `http://purl.obolibrary.org/obo/CL_0000249`
+### intracellular ligand-gated monoatomic ion channel activity `http://purl.obolibrary.org/obo/GO_0005217`
#### Removed
-- [hatching gland cell](http://purl.obolibrary.org/obo/CL_0000249) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [label](http://www.w3.org/2000/01/rdf-schema#label) "intracellular ligand-gated monoatomic ion channel activity"
+- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "intracellular ligand-gated ion channel activity"
-### heart `http://purl.obolibrary.org/obo/UBERON_0000948`
-
-#### Added
-- [heart](http://purl.obolibrary.org/obo/UBERON_0000948) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
+- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0005217"
-- [heart](http://purl.obolibrary.org/obo/UBERON_0000948) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
+- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0815340729"
-- [heart](http://purl.obolibrary.org/obo/UBERON_0000948) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Heart.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_transport"
+- Class: [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217)
-### heart left ventricle `http://purl.obolibrary.org/obo/UBERON_0002084`
+- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) SubClassOf [ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0015276)
-#### Added
-- [heart left ventricle](http://purl.obolibrary.org/obo/UBERON_0002084) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
-- [heart left ventricle](http://purl.obolibrary.org/obo/UBERON_0002084) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
+### invaginating midget bipolar cell `http://purl.obolibrary.org/obo/CL_4033034`
+#### Removed
+- [invaginating midget bipolar cell](http://purl.obolibrary.org/obo/CL_4033034) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "IMB cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### heart right ventricle `http://purl.obolibrary.org/obo/UBERON_0002080`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
#### Added
-- [heart right ventricle](http://purl.obolibrary.org/obo/UBERON_0002080) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
+- [invaginating midget bipolar cell](http://purl.obolibrary.org/obo/CL_4033034) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "IMB cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
-- [heart right ventricle](http://purl.obolibrary.org/obo/UBERON_0002080) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### hematopoietic cell `http://purl.obolibrary.org/obo/CL_0000988`
-#### Removed
-- [hematopoietic cell](http://purl.obolibrary.org/obo/CL_0000988) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### ionocyte `http://purl.obolibrary.org/obo/CL_0005006`
#### Added
-- [hematopoietic cell](http://purl.obolibrary.org/obo/CL_0000988) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [ionocyte](http://purl.obolibrary.org/obo/CL_0005006) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [ionocyte](http://purl.obolibrary.org/obo/CL_0005006) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### hemocyte (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000387`
+### ionotropic glutamate receptor activity `http://purl.obolibrary.org/obo/GO_0004970`
#### Added
-- [hemocyte (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000387) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0004970"
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) [label](http://www.w3.org/2000/01/rdf-schema#label) "ionotropic glutamate receptor activity"
-### hepatic oval stem cell `http://purl.obolibrary.org/obo/CL_0002196`
-#### Removed
-- [hepatic oval stem cell](http://purl.obolibrary.org/obo/CL_0002196) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'."
-### hepatic portal vein `http://purl.obolibrary.org/obo/UBERON_0001639`
+- Class: [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970)
-#### Added
-- [hepatic portal vein](http://purl.obolibrary.org/obo/UBERON_0001639) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_24867](http://purl.obolibrary.org/obo/CHEBI_24867)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_14321](http://purl.obolibrary.org/obo/CHEBI_14321))
-- [hepatic portal vein](http://purl.obolibrary.org/obo/UBERON_0001639) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) SubClassOf [glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0008066)
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235)
-### hepatocyte `http://purl.obolibrary.org/obo/CL_0000182`
-#### Removed
-- [hepatocyte](http://purl.obolibrary.org/obo/CL_0000182) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) SubClassOf [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_14321](http://purl.obolibrary.org/obo/CHEBI_14321)
+- [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970) SubClassOf [transmitter-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0022824)
-### hindlimb skin `http://purl.obolibrary.org/obo/UBERON_0003532`
+### ionotropic glutamate receptor complex `http://purl.obolibrary.org/obo/GO_0008328`
#### Added
-- [hindlimb skin](http://purl.obolibrary.org/obo/UBERON_0003532) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lower limb skin"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0002-0819-0473"
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0008328"
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) [label](http://www.w3.org/2000/01/rdf-schema#label) "ionotropic glutamate receptor complex"
-### histoblast `http://purl.obolibrary.org/obo/CL_0000373`
-#### Removed
-- [histoblast](http://purl.obolibrary.org/obo/CL_0000373) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component"
-#### Added
-- [histoblast](http://purl.obolibrary.org/obo/CL_0000373) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html"
+- Class: [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328)
-### hypothalamus `http://purl.obolibrary.org/obo/UBERON_0001898`
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) EquivalentTo [protein-containing complex](http://purl.obolibrary.org/obo/GO_0032991) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970))
-#### Added
-- [hypothalamus](http://purl.obolibrary.org/obo/UBERON_0001898) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) SubClassOf [neurotransmitter receptor complex](http://purl.obolibrary.org/obo/GO_0098878)
-- [hypothalamus](http://purl.obolibrary.org/obo/UBERON_0001898) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) SubClassOf [monoatomic ion channel complex](http://purl.obolibrary.org/obo/GO_0034702)
+- [ionotropic glutamate receptor complex](http://purl.obolibrary.org/obo/GO_0008328) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970)
-### hypothalamus cell `http://purl.obolibrary.org/obo/CL_2000030`
-#### Removed
-- [hypothalamus cell](http://purl.obolibrary.org/obo/CL_2000030) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [hypothalamus](http://purl.obolibrary.org/obo/UBERON_0001898))
+
+### ionotropic glutamate receptor signaling pathway `http://purl.obolibrary.org/obo/GO_0035235`
#### Added
-- [hypothalamus cell](http://purl.obolibrary.org/obo/CL_2000030) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [hypothalamus](http://purl.obolibrary.org/obo/UBERON_0001898))
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0035235"
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) [label](http://www.w3.org/2000/01/rdf-schema#label) "ionotropic glutamate receptor signaling pathway"
-### ileocolic artery `http://purl.obolibrary.org/obo/UBERON_0001197`
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:signaling"
-#### Added
-- [ileocolic artery](http://purl.obolibrary.org/obo/UBERON_0001197) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [ileocolic artery](http://purl.obolibrary.org/obo/UBERON_0001197) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ionotropic glutamate receptor signalling pathway"
-### ileocolic vein `http://purl.obolibrary.org/obo/UBERON_0001219`
+- Class: [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235)
-#### Added
-- [ileocolic vein](http://purl.obolibrary.org/obo/UBERON_0001219) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) EquivalentTo [signal transduction](http://purl.obolibrary.org/obo/GO_0007165) and ([starts with](http://purl.obolibrary.org/obo/RO_0002224) some [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970))
-- [ileocolic vein](http://purl.obolibrary.org/obo/UBERON_0001219) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) SubClassOf [starts with](http://purl.obolibrary.org/obo/RO_0002224) some [ionotropic glutamate receptor activity](http://purl.obolibrary.org/obo/GO_0004970)
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) SubClassOf [glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0007215)
-### ileum `http://purl.obolibrary.org/obo/UBERON_0002116`
+- [ionotropic glutamate receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0035235) SubClassOf [ligand-gated ion channel signaling pathway](http://purl.obolibrary.org/obo/GO_1990806)
-#### Added
-- [ileum](http://purl.obolibrary.org/obo/UBERON_0002116) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb"
-- [ileum](http://purl.obolibrary.org/obo/UBERON_0002116) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb"
+### is small molecule activator of `http://purl.obolibrary.org/obo/RO_0012005`
+#### Added
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
-### ilium `http://purl.obolibrary.org/obo/UBERON_0001273`
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2020-06-24T13:15:26Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-#### Added
-- [ilium](http://purl.obolibrary.org/obo/UBERON_0001273) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pelvis.glb"
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
-- [ilium](http://purl.obolibrary.org/obo/UBERON_0001273) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pelvis.glb"
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Is_small_molecule_activator_of"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) [label](http://www.w3.org/2000/01/rdf-schema#label) "is small molecule activator of"@en
-### imaginal disc cell `http://purl.obolibrary.org/obo/CL_0000429`
+- ObjectProperty: [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005)
-#### Added
-- [imaginal disc cell](http://purl.obolibrary.org/obo/CL_0000429) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) SubPropertyOf: [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004)
+- [is small molecule activator of](http://purl.obolibrary.org/obo/RO_0012005) SubPropertyOf: [capable of positively regulating](http://purl.obolibrary.org/obo/RO_0002598)
-### indoleamine-accumulating amacrine cell `http://purl.obolibrary.org/obo/CL_0004245`
-#### Removed
-- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a wide dendritic field and post-synaptic terminals in S5."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
-- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+### is small molecule regulator of `http://purl.obolibrary.org/obo/RO_0012004`
#### Added
-- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a wide dendritic field and post-synaptic terminals in S5. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and serotonin."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12486181"
+- [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
-- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) SubClassOf [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253)
+- [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2020-06-24T13:15:17Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) SubClassOf [serotonergic neuron](http://purl.obolibrary.org/obo/CL_0000850)
+- [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004) [label](http://www.w3.org/2000/01/rdf-schema#label) "is small molecule regulator of"@en
-- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) SubClassOf [GABAergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030027)
+- ObjectProperty: [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004)
+- [is small molecule regulator of](http://purl.obolibrary.org/obo/RO_0012004) SubPropertyOf: [capable of regulating](http://purl.obolibrary.org/obo/RO_0002596)
-### inferior mesenteric artery `http://purl.obolibrary.org/obo/UBERON_0001183`
-#### Added
-- [inferior mesenteric artery](http://purl.obolibrary.org/obo/UBERON_0001183) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+### kidney cell `http://purl.obolibrary.org/obo/CL_1000497`
-- [inferior mesenteric artery](http://purl.obolibrary.org/obo/UBERON_0001183) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+#### Added
+- [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a kidney."
-### inferior mesenteric vein `http://purl.obolibrary.org/obo/UBERON_0001215`
+### kidney collecting duct cell `http://purl.obolibrary.org/obo/CL_1001225`
+#### Removed
+- [kidney collecting duct cell](http://purl.obolibrary.org/obo/CL_1001225) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
#### Added
-- [inferior mesenteric vein](http://purl.obolibrary.org/obo/UBERON_0001215) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [kidney collecting duct cell](http://purl.obolibrary.org/obo/CL_1001225) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a collecting duct of renal tubule."
+- [kidney collecting duct cell](http://purl.obolibrary.org/obo/CL_1001225) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
-### inflammatory cell `http://purl.obolibrary.org/obo/CL_0009002`
+
+### kidney connecting tubule principal cell `http://purl.obolibrary.org/obo/CL_4030018`
#### Removed
-- [inflammatory cell](http://purl.obolibrary.org/obo/CL_0009002) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [kidney connecting tubule principal cell](http://purl.obolibrary.org/obo/CL_4030018) SubClassOf [kidney tubule cell](http://purl.obolibrary.org/obo/CL_1000507)
+
+- [kidney connecting tubule principal cell](http://purl.obolibrary.org/obo/CL_4030018) SubClassOf [epithelial cell of nephron](http://purl.obolibrary.org/obo/CL_1000449)
+
+- [kidney connecting tubule principal cell](http://purl.obolibrary.org/obo/CL_4030018) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [renal connecting tubule](http://purl.obolibrary.org/obo/UBERON_0005097)
#### Added
-- [inflammatory cell](http://purl.obolibrary.org/obo/CL_0009002) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [kidney connecting tubule principal cell](http://purl.obolibrary.org/obo/CL_4030018) SubClassOf [kidney connecting tubule epithelial cell](http://purl.obolibrary.org/obo/CL_1000768)
+
+### kidney cortex collecting duct epithelial cell `http://purl.obolibrary.org/obo/CL_1000549`
+#### Removed
+- [kidney cortex collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000549) EquivalentTo [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cortical collecting duct](http://purl.obolibrary.org/obo/UBERON_0004203))
-### information content entity `http://purl.obolibrary.org/obo/IAO_0000030`
+- [kidney cortex collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000549) SubClassOf [kidney cortical cell](http://purl.obolibrary.org/obo/CL_0002681)
#### Added
-- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "information content entity"@en
+- [kidney cortex collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000549) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An epithelial cell that is part of a cortical collecting duct."
-- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [label](http://www.w3.org/2000/01/rdf-schema#label) "information content entity"@en
+- [kidney cortex collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000549) EquivalentTo [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cortical collecting duct](http://purl.obolibrary.org/obo/UBERON_0004203))
-- Class: [information content entity](http://purl.obolibrary.org/obo/IAO_0000030)
+- [kidney cortex collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000549) SubClassOf [renal cortical epithelial cell](http://purl.obolibrary.org/obo/CL_0002584)
-- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031)
+- [kidney cortex collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000549) SubClassOf [epithelial cell of nephron](http://purl.obolibrary.org/obo/CL_1000449)
-### inner cell mass cell `http://purl.obolibrary.org/obo/CL_2000020`
+### kidney cortex collecting duct intercalated cell `http://purl.obolibrary.org/obo/CL_1000715`
#### Removed
-- [inner cell mass cell](http://purl.obolibrary.org/obo/CL_2000020) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [inner cell mass](http://purl.obolibrary.org/obo/UBERON_0000087))
+- [kidney cortex collecting duct intercalated cell](http://purl.obolibrary.org/obo/CL_1000715) SubClassOf [renal cortical epithelial cell](http://purl.obolibrary.org/obo/CL_0002584)
-- [inner cell mass cell](http://purl.obolibrary.org/obo/CL_2000020) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
-#### Added
-- [inner cell mass cell](http://purl.obolibrary.org/obo/CL_2000020) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [inner cell mass](http://purl.obolibrary.org/obo/UBERON_0000087))
-- [inner cell mass cell](http://purl.obolibrary.org/obo/CL_2000020) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+### kidney cortex collecting duct principal cell `http://purl.obolibrary.org/obo/CL_1000714`
+#### Removed
+- [kidney cortex collecting duct principal cell](http://purl.obolibrary.org/obo/CL_1000714) SubClassOf [renal cortical epithelial cell](http://purl.obolibrary.org/obo/CL_0002584)
+
-### internal iliac vein `http://purl.obolibrary.org/obo/UBERON_0001317`
+### kidney cortical cell `http://purl.obolibrary.org/obo/CL_0002681`
+#### Removed
+- [kidney cortical cell](http://purl.obolibrary.org/obo/CL_0002681) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
#### Added
-- [internal iliac vein](http://purl.obolibrary.org/obo/UBERON_0001317) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [kidney cortical cell](http://purl.obolibrary.org/obo/CL_0002681) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a cortex of kidney."
-- [internal iliac vein](http://purl.obolibrary.org/obo/UBERON_0001317) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [kidney cortical cell](http://purl.obolibrary.org/obo/CL_0002681) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
-### internal pudendal vein `http://purl.obolibrary.org/obo/UBERON_0018252`
+### kidney inner medulla collecting duct epithelial cell `http://purl.obolibrary.org/obo/CL_1000547`
+#### Removed
+- [kidney inner medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000547) EquivalentTo [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [inner medullary collecting duct](http://purl.obolibrary.org/obo/UBERON_0004205))
+
+- [kidney inner medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000547) SubClassOf [kidney collecting duct cell](http://purl.obolibrary.org/obo/CL_1001225)
#### Added
-- [internal pudendal vein](http://purl.obolibrary.org/obo/UBERON_0018252) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [kidney inner medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000547) EquivalentTo [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [inner medullary collecting duct](http://purl.obolibrary.org/obo/UBERON_0004205))
-- [internal pudendal vein](http://purl.obolibrary.org/obo/UBERON_0018252) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [kidney inner medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000547) SubClassOf [kidney medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000546)
-### interstitial cell `http://purl.obolibrary.org/obo/CL_4030031`
+### kidney interstitial cell `http://purl.obolibrary.org/obo/CL_1000500`
#### Removed
-- [interstitial cell](http://purl.obolibrary.org/obo/CL_4030031) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [interstitial tissue](http://purl.obolibrary.org/obo/UBERON_0005169))
-
-- [interstitial cell](http://purl.obolibrary.org/obo/CL_4030031) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [kidney interstitial cell](http://purl.obolibrary.org/obo/CL_1000500) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
#### Added
-- [interstitial cell](http://purl.obolibrary.org/obo/CL_4030031) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [interstitial tissue](http://purl.obolibrary.org/obo/UBERON_0005169))
+- [kidney interstitial cell](http://purl.obolibrary.org/obo/CL_1000500) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of kidney interstitium."
-- [interstitial cell](http://purl.obolibrary.org/obo/CL_4030031) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [kidney interstitial cell](http://purl.obolibrary.org/obo/CL_1000500) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
-### interventricular septum `http://purl.obolibrary.org/obo/UBERON_0002094`
+### kidney medulla cell `http://purl.obolibrary.org/obo/CL_1000504`
+#### Removed
+- [kidney medulla cell](http://purl.obolibrary.org/obo/CL_1000504) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
#### Added
-- [interventricular septum](http://purl.obolibrary.org/obo/UBERON_0002094) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
+- [kidney medulla cell](http://purl.obolibrary.org/obo/CL_1000504) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a renal medulla."
-- [interventricular septum](http://purl.obolibrary.org/obo/UBERON_0002094) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
+- [kidney medulla cell](http://purl.obolibrary.org/obo/CL_1000504) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
-### intrapulmonary bronchus `http://purl.obolibrary.org/obo/UBERON_0035767`
+### kidney medulla collecting duct epithelial cell `http://purl.obolibrary.org/obo/CL_1000546`
#### Removed
-- [intrapulmonary bronchus](http://purl.obolibrary.org/obo/UBERON_0035767) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [kidney medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000546) EquivalentTo [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [renal medulla collecting duct](http://purl.obolibrary.org/obo/UBERON_0005185))
-- [intrapulmonary bronchus](http://purl.obolibrary.org/obo/UBERON_0035767) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+#### Added
+- [kidney medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000546) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An epithelial cell that is part of a renal medulla collecting duct."
+- [kidney medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000546) EquivalentTo [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [renal medulla collecting duct](http://purl.obolibrary.org/obo/UBERON_0005185))
+- [kidney medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000546) SubClassOf [epithelial cell of nephron](http://purl.obolibrary.org/obo/CL_1000449)
-### ionocyte `http://purl.obolibrary.org/obo/CL_0005006`
+
+### kidney outer medulla collecting duct epithelial cell `http://purl.obolibrary.org/obo/CL_1000548`
#### Removed
-- [ionocyte](http://purl.obolibrary.org/obo/CL_0005006) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [kidney outer medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000548) EquivalentTo [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [outer medullary collecting duct](http://purl.obolibrary.org/obo/UBERON_0004204))
+- [kidney outer medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000548) SubClassOf [kidney collecting duct cell](http://purl.obolibrary.org/obo/CL_1001225)
+#### Added
+- [kidney outer medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000548) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An epithelial cell that is part of an outer medullary collecting duct."
-### iridoblast `http://purl.obolibrary.org/obo/CL_0005001`
-#### Removed
-- [iridoblast](http://purl.obolibrary.org/obo/CL_0005001) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [kidney outer medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000548) EquivalentTo [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [outer medullary collecting duct](http://purl.obolibrary.org/obo/UBERON_0004204))
+- [kidney outer medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000548) SubClassOf [kidney medulla collecting duct epithelial cell](http://purl.obolibrary.org/obo/CL_1000546)
-### iridophore `http://purl.obolibrary.org/obo/CL_0000431`
+### kidney pelvis cell `http://purl.obolibrary.org/obo/CL_1000505`
#### Removed
-- [iridophore](http://purl.obolibrary.org/obo/CL_0000431) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [kidney pelvis cell](http://purl.obolibrary.org/obo/CL_1000505) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+
+#### Added
+- [kidney pelvis cell](http://purl.obolibrary.org/obo/CL_1000505) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a renal pelvis."
+- [kidney pelvis cell](http://purl.obolibrary.org/obo/CL_1000505) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
-### ischium `http://purl.obolibrary.org/obo/UBERON_0001274`
+### kidney tubule cell `http://purl.obolibrary.org/obo/CL_1000507`
+#### Removed
+- [kidney tubule cell](http://purl.obolibrary.org/obo/CL_1000507) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
#### Added
-- [ischium](http://purl.obolibrary.org/obo/UBERON_0001274) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pelvis.glb"
+- [kidney tubule cell](http://purl.obolibrary.org/obo/CL_1000507) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a nephron tubule."
-- [ischium](http://purl.obolibrary.org/obo/UBERON_0001274) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pelvis.glb"
+- [kidney tubule cell](http://purl.obolibrary.org/obo/CL_1000507) SubClassOf [kidney cell](http://purl.obolibrary.org/obo/CL_1000497)
-### jejunum `http://purl.obolibrary.org/obo/UBERON_0002115`
+### lactocyte type 1 `http://purl.obolibrary.org/obo/CL_4033059`
#### Added
-- [jejunum](http://purl.obolibrary.org/obo/UBERON_0002115) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb"
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LC1"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-- [jejunum](http://purl.obolibrary.org/obo/UBERON_0002115) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [label](http://www.w3.org/2000/01/rdf-schema#label) "lactocyte type 1"
-### kidney capsule `http://purl.obolibrary.org/obo/UBERON_0002015`
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal cluster 1 cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34097179"
-#### Added
-- [kidney capsule](http://purl.obolibrary.org/obo/UBERON_0002015) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb"
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A lactocyte that highly expresses genes associated with transcription, immune cell function, and cellular stress. A lactocyte type 1 also expresses genes involved in milk component biosynthesis (e.g., LALBA and CSNs), albeit at lower levels than a lactocyte type 2."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-- [kidney capsule](http://purl.obolibrary.org/obo/UBERON_0002015) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_R.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35377806"
-- [kidney capsule](http://purl.obolibrary.org/obo/UBERON_0002015) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb"
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "progenitor MEC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-- [kidney capsule](http://purl.obolibrary.org/obo/UBERON_0002015) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-### kidney cell `http://purl.obolibrary.org/obo/CL_1000497`
-#### Removed
-- [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [kidney](http://purl.obolibrary.org/obo/UBERON_0002113))
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LMC major luminal cluster 1"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-- [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [date](http://purl.org/dc/terms/date) "2023-10-16T13:15:36Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-#### Added
-- [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [kidney](http://purl.obolibrary.org/obo/UBERON_0002113))
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) [contributor](http://purl.org/dc/terms/contributor) [X](https://orcid.org/0000-0003-4361-817X)
-- [kidney cell](http://purl.obolibrary.org/obo/CL_1000497) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- Class: [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059)
+- [lactocyte type 1](http://purl.obolibrary.org/obo/CL_4033059) SubClassOf [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325)
-### kidney pyramid `http://purl.obolibrary.org/obo/UBERON_0004200`
+
+### lactocyte type 2 `http://purl.obolibrary.org/obo/CL_4033060`
#### Added
-- [kidney pyramid](http://purl.obolibrary.org/obo/UBERON_0004200) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb"
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal cluster 2 cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35377806"
-- [kidney pyramid](http://purl.obolibrary.org/obo/UBERON_0004200) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_R.glb"
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LMC major luminal cluster 2"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-- [kidney pyramid](http://purl.obolibrary.org/obo/UBERON_0004200) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb"
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [contributor](http://purl.org/dc/terms/contributor) [X](https://orcid.org/0000-0003-4361-817X)
-- [kidney pyramid](http://purl.obolibrary.org/obo/UBERON_0004200) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb"
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [label](http://www.w3.org/2000/01/rdf-schema#label) "lactocyte type 2"
-### labyrinth supporting cell `http://purl.obolibrary.org/obo/CL_0000631`
-#### Removed
-- [labyrinth supporting cell](http://purl.obolibrary.org/obo/CL_0000631) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LC2"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A lactocyte that highly expresses genes associated with lipid production and milk component biosynthesis."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-### large intestine `http://purl.obolibrary.org/obo/UBERON_0000059`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35377806"
-#### Added
-- [large intestine](http://purl.obolibrary.org/obo/UBERON_0000059) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) [date](http://purl.org/dc/terms/date) "2023-10-16T13:15:55Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [large intestine](http://purl.obolibrary.org/obo/UBERON_0000059) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+- Class: [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060)
-- [large intestine](http://purl.obolibrary.org/obo/UBERON_0000059) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/SBU_F_Intestine_Large.glb"
+- [lactocyte type 2](http://purl.obolibrary.org/obo/CL_4033060) SubClassOf [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325)
-### larval midgut cell `http://purl.obolibrary.org/obo/CL_0009003`
+### ligand-gated calcium channel activity `http://purl.obolibrary.org/obo/GO_0099604`
#### Removed
-- [larval midgut cell](http://purl.obolibrary.org/obo/CL_0009003) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [ligand-gated calcium channel activity](http://purl.obolibrary.org/obo/GO_0099604) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108))
#### Added
-- [larval midgut cell](http://purl.obolibrary.org/obo/CL_0009003) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [ligand-gated calcium channel activity](http://purl.obolibrary.org/obo/GO_0099604) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431))
-### laryngeal cartilage `http://purl.obolibrary.org/obo/UBERON_0001739`
+### ligand-gated channel activity `http://purl.obolibrary.org/obo/GO_0022834`
#### Added
-- [laryngeal cartilage](http://purl.obolibrary.org/obo/UBERON_0001739) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-larynx.glb"
+- [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431))
-- [laryngeal cartilage](http://purl.obolibrary.org/obo/UBERON_0001739) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-larynx.glb"
+- [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) SubClassOf [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431)
-### larynx `http://purl.obolibrary.org/obo/UBERON_0001737`
+### ligand-gated monoatomic cation channel activity `http://purl.obolibrary.org/obo/GO_0099094`
+#### Removed
+- [ligand-gated monoatomic cation channel activity](http://purl.obolibrary.org/obo/GO_0099094) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906))
#### Added
-- [larynx](http://purl.obolibrary.org/obo/UBERON_0001737) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-larynx.glb"
+- [ligand-gated monoatomic cation channel activity](http://purl.obolibrary.org/obo/GO_0099094) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431))
-- [larynx](http://purl.obolibrary.org/obo/UBERON_0001737) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-larynx.glb"
-
-### leading edge cell `http://purl.obolibrary.org/obo/CL_0000730`
+### ligand-gated monoatomic ion channel activity `http://purl.obolibrary.org/obo/GO_0015276`
#### Removed
-- [leading edge cell](http://purl.obolibrary.org/obo/CL_0000730) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
-
+- [ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0015276) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_24867](http://purl.obolibrary.org/obo/CHEBI_24867))
-
-### left cardiac atrium `http://purl.obolibrary.org/obo/UBERON_0002079`
+- [ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0015276) SubClassOf [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839)
#### Added
-- [left cardiac atrium](http://purl.obolibrary.org/obo/UBERON_0002079) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
+- [ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0015276) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_24867](http://purl.obolibrary.org/obo/CHEBI_24867)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24431](http://purl.obolibrary.org/obo/CHEBI_24431))
-- [left cardiac atrium](http://purl.obolibrary.org/obo/UBERON_0002079) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
+- [ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0015276) SubClassOf [monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005216)
-### left cerebral hemisphere `http://purl.obolibrary.org/obo/UBERON_0002812`
+### luminal adaptive secretory precursor cell of mammary gland `http://purl.obolibrary.org/obo/CL_4033057`
#### Added
-- [left cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002812) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0001-6677-8489"
-- [left cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002812) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19648928"
-### left common carotid artery plus branches `http://purl.obolibrary.org/obo/UBERON_0001536`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35617956"
-#### Added
-- [left common carotid artery plus branches](http://purl.obolibrary.org/obo/UBERON_0001536) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-- [left common carotid artery plus branches](http://purl.obolibrary.org/obo/UBERON_0001536) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### left eye `http://purl.obolibrary.org/obo/UBERON_0004548`
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [date](http://purl.org/dc/terms/date) "2023-10-13T13:02:55Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-#### Added
-- [left eye](http://purl.obolibrary.org/obo/UBERON_0004548) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal secretory cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37380767"
-- [left eye](http://purl.obolibrary.org/obo/UBERON_0004548) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LumSec"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [left eye](http://purl.obolibrary.org/obo/UBERON_0004548) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-l.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37380767"
-- [left eye](http://purl.obolibrary.org/obo/UBERON_0004548) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-l.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AV"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35617956"
-### left kidney `http://purl.obolibrary.org/obo/UBERON_0004538`
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "alveolar progenitor"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26390871"
-#### Added
-- [left kidney](http://purl.obolibrary.org/obo/UBERON_0004538) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LASP"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0001-6677-8489"
-- [left kidney](http://purl.obolibrary.org/obo/UBERON_0004538) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [left kidney](http://purl.obolibrary.org/obo/UBERON_0004538) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Kidney_Left.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER-negative luminal alveolar progenitor"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "alveolar cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35617956"
-### left lobe of liver `http://purl.obolibrary.org/obo/UBERON_0001115`
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [left lobe of liver](http://purl.obolibrary.org/obo/UBERON_0001115) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2023.04.21.537845"
-- [left lobe of liver](http://purl.obolibrary.org/obo/UBERON_0001115) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [contributor](http://purl.org/dc/terms/contributor) [X](https://orcid.org/0000-0003-4969-670X)
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal progenitor"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2023.04.21.537845"
-### left lung `http://purl.obolibrary.org/obo/UBERON_0002168`
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal progenitor cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20346151"
-#### Added
-- [left lung](http://purl.obolibrary.org/obo/UBERON_0002168) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) [label](http://www.w3.org/2000/01/rdf-schema#label) "luminal adaptive secretory precursor cell of mammary gland"
-- [left lung](http://purl.obolibrary.org/obo/UBERON_0002168) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+- Class: [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057)
-- [left lung](http://purl.obolibrary.org/obo/UBERON_0002168) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) SubClassOf [luminal epithelial cell of mammary gland](http://purl.obolibrary.org/obo/CL_0002326)
-- [left lung](http://purl.obolibrary.org/obo/UBERON_0002168) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+- [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057) SubClassOf [progenitor cell](http://purl.obolibrary.org/obo/CL_0011026)
-### left nipple `http://purl.obolibrary.org/obo/UBERON_0013772`
+### luminal hormone-sensing cell of mammary gland `http://purl.obolibrary.org/obo/CL_4033058`
#### Added
-- [left nipple](http://purl.obolibrary.org/obo/UBERON_0013772) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.3/3d-vh-f-mammary-gland-l.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [contributor](http://purl.org/dc/terms/contributor) [X](https://orcid.org/0000-0003-4969-670X)
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HS"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### left pulmonary artery `http://purl.obolibrary.org/obo/UBERON_0001652`
-
-#### Added
-- [left pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0001652) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2023.04.21.537845"
-- [left pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0001652) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Following lineage specification, a luminal hormone-sensing cell expresses receptors for one or more hormones, such as estrogens, progesterone, androgens, and prolactin. In response to progesterone, luminal hormone-sensing cells express TNFSF11, WNT4, and RSPO1, among other factors, which cause branching, proliferation, and partial differentiation in LASP and B-Myo cells during luteal phases of the estrous/menstrual cycle and during gestation. During ductal elongation, ER activity drives expression of AREG in LHS cells, which is necessary for proliferation of the epithelium to fill the mammary fat pad."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26390871"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0003-4969-670X"
-### left putamen `http://purl.obolibrary.org/obo/UBERON_0008884`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34156490"
-#### Added
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal hormone-responsive cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37380767"
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "luminal mature cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20346151"
-### left renal artery `http://purl.obolibrary.org/obo/UBERON_0001186`
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LumHR"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [left renal artery](http://purl.obolibrary.org/obo/UBERON_0001186) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37380767"
-- [left renal artery](http://purl.obolibrary.org/obo/UBERON_0001186) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [date](http://purl.org/dc/terms/date) "2023-10-16T08:30:25Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [label](http://www.w3.org/2000/01/rdf-schema#label) "luminal hormone-sensing cell of mammary gland"
-### left renal vein `http://purl.obolibrary.org/obo/UBERON_0001142`
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A luminal epithelial cell of the mammary gland that transduces endocrine cues to orchestrate proliferation, architectural remodeling, and differentiation of other cells in the mammary gland via paracrine signaling. This cell expresses high levels of estrogen receptors. In humans, a luminal hormone-sensing cell can be identified by high levels of EpCAM and low levels of CD49f, and in mice it can be identified by low levels of CD29 and high levels of Foxa1, CD133, and Sca1 (Ly6a)."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0001-6677-8489"
-#### Added
-- [left renal vein](http://purl.obolibrary.org/obo/UBERON_0001142) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26390871"
-- [left renal vein](http://purl.obolibrary.org/obo/UBERON_0001142) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19648928"
-### left subclavian artery `http://purl.obolibrary.org/obo/UBERON_0001584`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34156490"
-#### Added
-- [left subclavian artery](http://purl.obolibrary.org/obo/UBERON_0001584) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "hormone sensing cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2023.04.21.537845"
-- [left subclavian artery](http://purl.obolibrary.org/obo/UBERON_0001584) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ER-positive luminal hormone-sensor cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HS-MEC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26390871"
-### left thymus lobe `http://purl.obolibrary.org/obo/UBERON_0005457`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [left thymus lobe](http://purl.obolibrary.org/obo/UBERON_0005457) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Thymus.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "hormone-sensing mammary epithelial cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26390871"
-- [left thymus lobe](http://purl.obolibrary.org/obo/UBERON_0005457) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Thymus.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LHS"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0001-6677-8489"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### left ureter `http://purl.obolibrary.org/obo/UBERON_0001223`
+- Class: [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058)
-#### Added
-- [left ureter](http://purl.obolibrary.org/obo/UBERON_0001223) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Ureter_L.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) SubClassOf [luminal epithelial cell of mammary gland](http://purl.obolibrary.org/obo/CL_0002326)
-- [left ureter](http://purl.obolibrary.org/obo/UBERON_0001223) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Ureter_L.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) SubClassOf [paracrine cell](http://purl.obolibrary.org/obo/CL_0000512)
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) SubClassOf [exocrine cell](http://purl.obolibrary.org/obo/CL_0000152)
-### left uterine tube `http://purl.obolibrary.org/obo/UBERON_0001303`
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567)
-#### Added
-- [left uterine tube](http://purl.obolibrary.org/obo/UBERON_0001303) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Fallopian_Tube_L.glb"
+- [luminal hormone-sensing cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033058) SubClassOf [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) some [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204)
-### leucoblast `http://purl.obolibrary.org/obo/CL_0005003`
+### lung endothelial cell `http://purl.obolibrary.org/obo/CL_1001567`
#### Removed
-- [leucoblast](http://purl.obolibrary.org/obo/CL_0005003) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
+- [lung endothelial cell](http://purl.obolibrary.org/obo/CL_1001567) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [lung endothelial cell](http://purl.obolibrary.org/obo/CL_1001567) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### leucophore `http://purl.obolibrary.org/obo/CL_0000571`
-#### Removed
-- [leucophore](http://purl.obolibrary.org/obo/CL_0000571) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+### lung goblet cell `http://purl.obolibrary.org/obo/CL_1000143`
+#### Removed
+- [lung goblet cell](http://purl.obolibrary.org/obo/CL_1000143) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### leukocyte `http://purl.obolibrary.org/obo/CL_0000738`
+- [lung goblet cell](http://purl.obolibrary.org/obo/CL_1000143) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-#### Added
-- [leukocyte](http://purl.obolibrary.org/obo/CL_0000738) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
-### ligament cell `http://purl.obolibrary.org/obo/CL_0000384`
+### lung interstitial macrophage `http://purl.obolibrary.org/obo/CL_4033043`
#### Removed
-- [ligament cell](http://purl.obolibrary.org/obo/CL_0000384) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-
+- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung IM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### liver `http://purl.obolibrary.org/obo/UBERON_0002107`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36211428"
#### Added
-- [liver](http://purl.obolibrary.org/obo/UBERON_0002107) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb"
+- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [liver](http://purl.obolibrary.org/obo/UBERON_0002107) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb"
+- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung IM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36211428"
-### lobar bronchus of left lung `http://purl.obolibrary.org/obo/UBERON_0003405`
+- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-#### Added
-- [lobar bronchus of left lung](http://purl.obolibrary.org/obo/UBERON_0003405) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
-- [lobar bronchus of left lung](http://purl.obolibrary.org/obo/UBERON_0003405) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+### lung megakaryocyte `http://purl.obolibrary.org/obo/CL_4033018`
+#### Removed
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MKL"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [lobar bronchus of left lung](http://purl.obolibrary.org/obo/UBERON_0003405) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131"
-- [lobar bronchus of left lung](http://purl.obolibrary.org/obo/UBERON_0003405) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung MKs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33351116"
-### lobar bronchus of right lung `http://purl.obolibrary.org/obo/UBERON_0003404`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
#### Added
-- [lobar bronchus of right lung](http://purl.obolibrary.org/obo/UBERON_0003404) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung MKs"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33351116"
-- [lobar bronchus of right lung](http://purl.obolibrary.org/obo/UBERON_0003404) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [lobar bronchus of right lung](http://purl.obolibrary.org/obo/UBERON_0003404) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-- [lobar bronchus of right lung](http://purl.obolibrary.org/obo/UBERON_0003404) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MKL"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131"
-### lobular bronchiole `http://purl.obolibrary.org/obo/UBERON_8600000`
-#### Added
-- [lobular bronchiole](http://purl.obolibrary.org/obo/UBERON_8600000) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+### lung migratory dendritic cell `http://purl.obolibrary.org/obo/CL_4033045`
+#### Removed
+- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [lobular bronchiole](http://purl.obolibrary.org/obo/UBERON_8600000) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
-### lower urinary tract cell `http://purl.obolibrary.org/obo/CL_1000600`
-#### Removed
-- [lower urinary tract cell](http://purl.obolibrary.org/obo/CL_1000600) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lower urinary tract](http://purl.obolibrary.org/obo/UBERON_0001556))
+- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [lower urinary tract cell](http://purl.obolibrary.org/obo/CL_1000600) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
#### Added
-- [lower urinary tract cell](http://purl.obolibrary.org/obo/CL_1000600) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lower urinary tract](http://purl.obolibrary.org/obo/UBERON_0001556))
+- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [lower urinary tract cell](http://purl.obolibrary.org/obo/CL_1000600) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### lung `http://purl.obolibrary.org/obo/UBERON_0002048`
-
-#### Added
-- [lung](http://purl.obolibrary.org/obo/UBERON_0002048) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-- [lung](http://purl.obolibrary.org/obo/UBERON_0002048) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
-- [lung](http://purl.obolibrary.org/obo/UBERON_0002048) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [lung](http://purl.obolibrary.org/obo/UBERON_0002048) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
-### lung ciliated cell `http://purl.obolibrary.org/obo/CL_1000271`
+### lung neuroendocrine cell `http://purl.obolibrary.org/obo/CL_1000223`
#### Removed
-- [lung ciliated cell](http://purl.obolibrary.org/obo/CL_1000271) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PNEC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33355253"
+#### Added
+- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PNEC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33355253"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### lung megakaryocyte `http://purl.obolibrary.org/obo/CL_4033018`
-#### Removed
-- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung MKs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon/core#PLURAL)
+### lung perichondrial fibroblast `http://purl.obolibrary.org/obo/CL_4033026`
+#### Removed
+- [lung perichondrial fibroblast](http://purl.obolibrary.org/obo/CL_4033026) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PC-fibro"
- [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33351116"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36543915"
#### Added
-- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung MKs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [lung perichondrial fibroblast](http://purl.obolibrary.org/obo/CL_4033026) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33351116"
+- [lung perichondrial fibroblast](http://purl.obolibrary.org/obo/CL_4033026) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [lung perichondrial fibroblast](http://purl.obolibrary.org/obo/CL_4033026) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PC-fibro"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36543915"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### lung migratory dendritic cell `http://purl.obolibrary.org/obo/CL_4033045`
+
+### lung resident memory CD4-positive, alpha-beta T cell `http://purl.obolibrary.org/obo/CL_4033038`
#### Removed
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDCs"
+- [lung resident memory CD4-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung CD4-positive TRM"
- [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31265968"
#### Added
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [lung resident memory CD4-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung CD4-positive TRM"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31265968"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [lung resident memory CD4-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033038) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### lung secretory cell `http://purl.obolibrary.org/obo/CL_1000272`
-#### Removed
-- [lung secretory cell](http://purl.obolibrary.org/obo/CL_1000272) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [lung resident memory CD4-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033038) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+### lung resident memory CD8-positive, alpha-beta T cell `http://purl.obolibrary.org/obo/CL_4033039`
+#### Removed
+- [lung resident memory CD8-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033039) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung CD8-positive TRM"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### luteal cell `http://purl.obolibrary.org/obo/CL_0000175`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31265968"
#### Added
-- [luteal cell](http://purl.obolibrary.org/obo/CL_0000175) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "corpus luteum cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16790079"
-
+- [lung resident memory CD8-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033039) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung CD8-positive TRM"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31265968"
-### lymph node T cell domain `http://purl.obolibrary.org/obo/UBERON_0010417`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [lymph node T cell domain](http://purl.obolibrary.org/obo/UBERON_0010417) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
+- [lung resident memory CD8-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033039) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [lymph node T cell domain](http://purl.obolibrary.org/obo/UBERON_0010417) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [lung resident memory CD8-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033039) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### lymph node follicle `http://purl.obolibrary.org/obo/UBERON_0010748`
+### lymph node lymphatic vessel endothelial cell `http://purl.obolibrary.org/obo/CL_0009115`
#### Added
-- [lymph node follicle](http://purl.obolibrary.org/obo/UBERON_0010748) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
+- [lymph node lymphatic vessel endothelial cell](http://purl.obolibrary.org/obo/CL_0009115) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [lymph node follicle](http://purl.obolibrary.org/obo/UBERON_0010748) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [lymph node lymphatic vessel endothelial cell](http://purl.obolibrary.org/obo/CL_0009115) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### lymph vasculature `http://purl.obolibrary.org/obo/UBERON_0004536`
+### macrophage activation involved in immune response `http://purl.obolibrary.org/obo/GO_0002281`
+#### Removed
+- [macrophage activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002281) SubClassOf [myeloid cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002275)
#### Added
-- [lymph vasculature](http://purl.obolibrary.org/obo/UBERON_0004536) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
+- [macrophage activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002281) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [myeloid cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002275)
-- [lymph vasculature](http://purl.obolibrary.org/obo/UBERON_0004536) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [macrophage activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002281) SubClassOf [leukocyte activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002366)
-### macroglial cell `http://purl.obolibrary.org/obo/CL_0000126`
+### mammary alveolar cell `http://purl.obolibrary.org/obo/CL_0002325`
#### Removed
-- [macroglial cell](http://purl.obolibrary.org/obo/CL_0000126) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "macroglia"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [label](http://www.w3.org/2000/01/rdf-schema#label) "mammary alveolar cell"
+
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The milk-producing cell of the alveolar unit that emerges during pregnancy."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1152/physrev.2001.81.2.871"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19022771"
#### Added
-- [macroglial cell](http://purl.obolibrary.org/obo/CL_0000126) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "macroglia"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1152/physrev.2001.81.2.871"
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [contributor](http://purl.org/dc/terms/contributor) [X](https://orcid.org/0000-0003-4361-817X)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [label](http://www.w3.org/2000/01/rdf-schema#label) "lactocyte"
-### male gamete `http://purl.obolibrary.org/obo/CL_0000408`
-#### Removed
-- [male gamete](http://purl.obolibrary.org/obo/CL_0000408) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LMC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lactation-derived mammary cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-### male genital duct `http://purl.obolibrary.org/obo/UBERON_0006947`
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lactaction-associated mammary epithelial cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-#### Added
-- [male genital duct](http://purl.obolibrary.org/obo/UBERON_0006947) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb"
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "mammary alveolar cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19022771"
+
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35091553"
-### male reproductive system `http://purl.obolibrary.org/obo/UBERON_0000079`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19022771"
-#### Added
-- [male reproductive system](http://purl.obolibrary.org/obo/UBERON_0000079) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35377806"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28717367"
-### male urethra `http://purl.obolibrary.org/obo/UBERON_0001333`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1177/156482659601700404"
-#### Added
-- [male urethra](http://purl.obolibrary.org/obo/UBERON_0001333) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urethra.glb"
+- [mammary alveolar cell](http://purl.obolibrary.org/obo/CL_0002325) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [luminal adaptive secretory precursor cell of mammary gland](http://purl.obolibrary.org/obo/CL_4033057)
-### mammary gland epithelial cell `http://purl.obolibrary.org/obo/CL_0002327`
+### mass `http://purl.obolibrary.org/obo/PATO_0000125`
#### Removed
-- [mammary gland epithelial cell](http://purl.obolibrary.org/obo/CL_0002327) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "quality"
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PATOC:GVG"
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [scalar_slim](http://purl.obolibrary.org/obo/pato#scalar_slim)
-### medulla of lymph node `http://purl.obolibrary.org/obo/UBERON_0002007`
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism."
-#### Added
-- [medulla of lymph node](http://purl.obolibrary.org/obo/UBERON_0002007) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [id](http://www.geneontology.org/formats/oboInOwl#id) "PATO:0000125"
-- [medulla of lymph node](http://purl.obolibrary.org/obo/UBERON_0002007) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [relational_slim](http://purl.obolibrary.org/obo/pato#relational_slim)
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [attribute_slim](http://purl.obolibrary.org/obo/pato#attribute_slim)
-### melanoblast `http://purl.obolibrary.org/obo/CL_0000541`
-#### Removed
-- [melanoblast](http://purl.obolibrary.org/obo/CL_0000541) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) [label](http://www.w3.org/2000/01/rdf-schema#label) "mass"
+- Class: [mass](http://purl.obolibrary.org/obo/PATO_0000125)
+
+- [mass](http://purl.obolibrary.org/obo/PATO_0000125) SubClassOf [physical quality](http://purl.obolibrary.org/obo/PATO_0001018)
-### melanocyte `http://purl.obolibrary.org/obo/CL_0000148`
-#### Removed
-- [melanocyte](http://purl.obolibrary.org/obo/CL_0000148) SubClassOf [pigment cell](http://purl.obolibrary.org/obo/CL_0000147)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
-- [melanocyte](http://purl.obolibrary.org/obo/CL_0000148) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### mast cell degranulation `http://purl.obolibrary.org/obo/GO_0043303`
+#### Removed
+- [mast cell degranulation](http://purl.obolibrary.org/obo/GO_0043303) SubClassOf [mast cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002279)
#### Added
-- [melanocyte](http://purl.obolibrary.org/obo/CL_0000148) SubClassOf [pigment cell](http://purl.obolibrary.org/obo/CL_0000147)
+- [mast cell degranulation](http://purl.obolibrary.org/obo/GO_0043303) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [mast cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002279)
-### mesenchymal cell `http://purl.obolibrary.org/obo/CL_0008019`
+### material anatomical entity `http://purl.obolibrary.org/obo/CARO_0000006`
#### Removed
-- [mesenchymal cell](http://purl.obolibrary.org/obo/CL_0008019) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An anatomical entity that has mass."
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) [label](http://www.w3.org/2000/01/rdf-schema#label) "material anatomical entity"
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000006"
-### mesenchymal stem cell `http://purl.obolibrary.org/obo/CL_0000134`
-#### Removed
-- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "mesenchymal progenitor cells"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PLURAL](http://purl.obolibrary.org/obo/cl#PLURAL)
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D044982"
+- Class: [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "stem cells, mesenchymal"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PLURAL](http://purl.obolibrary.org/obo/cl#PLURAL)
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) DisjointWith [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D044982"
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) DisjointWith [immaterial anatomical entity](http://purl.obolibrary.org/obo/CARO_0000007)
-- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "mesenchymal stromal cells"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PLURAL](http://purl.obolibrary.org/obo/cl#PLURAL)
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) EquivalentTo [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mass](http://purl.obolibrary.org/obo/PATO_0000125))
-#### Added
-- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "mesenchymal progenitor cells"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mass](http://purl.obolibrary.org/obo/PATO_0000125)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D044982"
+- [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "mesenchymal stromal cells"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "stem cells, mesenchymal"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D044982"
+### matrix D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030043`
+#### Removed
+- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1M"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+
+- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D1-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-matrix"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### mesenchymal stem cell of orbital adipose tissue `http://purl.obolibrary.org/obo/CL_4040004`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
#### Added
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [label](http://www.w3.org/2000/01/rdf-schema#label) "mesenchymal stem cell of orbital adipose tissue"
+- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-matrix"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "OAMSC"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31377878"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [date](http://purl.org/dc/terms/date) "2023-09-18T10:43:00Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D1-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-0819-0473](https://orcid.org/0000-0002-0819-0473)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Orbital ASCs"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30210548"
+- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1M"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any mesenchymal stem cell of adipose tissue that is part of an orbital region."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-0819-0473](https://orcid.org/0000-0002-0819-0473)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "orbital adipose-derived mesenchymal stem cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31377878"
-- Class: [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004)
+### matrix D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030047`
+#### Removed
+- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D2-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) EquivalentTo [mesenchymal stem cell of adipose tissue](http://purl.obolibrary.org/obo/CL_0002570) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [orbital region](http://purl.obolibrary.org/obo/UBERON_0004088))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [orbital region](http://purl.obolibrary.org/obo/UBERON_0004088)
+- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2M"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [mesenchymal stem cell of orbital adipose tissue](http://purl.obolibrary.org/obo/CL_4040004) SubClassOf [mesenchymal stem cell of adipose tissue](http://purl.obolibrary.org/obo/CL_0002570)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-matrix"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### mesenteric lymph node `http://purl.obolibrary.org/obo/UBERON_0002509`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
#### Added
-- [mesenteric lymph node](http://purl.obolibrary.org/obo/UBERON_0002509) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_M_Lymph_Node.glb"
+- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D2-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [mesenteric lymph node](http://purl.obolibrary.org/obo/UBERON_0002509) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/NIH_F_Lymph_Node.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2M"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### meso-epithelial cell `http://purl.obolibrary.org/obo/CL_0002078`
-#### Removed
-- [meso-epithelial cell](http://purl.obolibrary.org/obo/CL_0002078) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-matrix"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### mesothelial cell of anterior chamber of eye `http://purl.obolibrary.org/obo/CL_1000444`
+
+### mature CD4 single-positive thymocyte `http://purl.obolibrary.org/obo/CL_0002436`
#### Removed
-- [mesothelial cell of anterior chamber of eye](http://purl.obolibrary.org/obo/CL_1000444) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [mature CD4 single-positive thymocyte](http://purl.obolibrary.org/obo/CL_0002436) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "T.4SP24-.Th"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [mesothelial cell of anterior chamber of eye](http://purl.obolibrary.org/obo/CL_1000444) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
+- [mature CD4 single-positive thymocyte](http://purl.obolibrary.org/obo/CL_0002436) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "T.4SP24-.Th"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### mesothelial cell of dura mater `http://purl.obolibrary.org/obo/CL_1000298`
+### maximally connected `http://purl.obolibrary.org/obo/PATO_0010000`
#### Removed
-- [mesothelial cell of dura mater](http://purl.obolibrary.org/obo/CL_1000298) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
-
-#### Added
-- [mesothelial cell of dura mater](http://purl.obolibrary.org/obo/CL_1000298) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [id](http://www.geneontology.org/formats/oboInOwl#id) "PATO:0010000"
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos"
-### mesothelial cell of peritoneum `http://purl.obolibrary.org/obo/CL_1000490`
-#### Removed
-- [mesothelial cell of peritoneum](http://purl.obolibrary.org/obo/CL_1000490) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [label](http://www.w3.org/2000/01/rdf-schema#label) "maximally connected"
-#### Added
-- [mesothelial cell of peritoneum](http://purl.obolibrary.org/obo/CL_1000490) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "What counts as maximally connected may be relative to some specification of granularity."
-### mesothelial cell of pleura `http://purl.obolibrary.org/obo/CL_1000491`
-#### Removed
-- [mesothelial cell of pleura](http://purl.obolibrary.org/obo/CL_1000491) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "quality"
-#### Added
-- [mesothelial cell of pleura](http://purl.obolibrary.org/obo/CL_1000491) SubClassOf [mesothelial cell](http://purl.obolibrary.org/obo/CL_0000077)
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-12-12T08:41:11Z"
+- Class: [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000)
-### metadata complete `http://purl.obolibrary.org/obo/IAO_0000120`
+- [maximally connected](http://purl.obolibrary.org/obo/PATO_0010000) SubClassOf [structure](http://purl.obolibrary.org/obo/PATO_0000141)
-#### Added
-- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata complete"@en
-- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata complete"@en
-- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en
+### medullary reticular cell `http://purl.obolibrary.org/obo/CL_0009106`
+#### Removed
+- [medullary reticular cell](http://purl.obolibrary.org/obo/CL_0009106) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MedRC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- Individual: [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120)
+#### Added
+- [medullary reticular cell](http://purl.obolibrary.org/obo/CL_0009106) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MedRC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### metadata incomplete `http://purl.obolibrary.org/obo/IAO_0000123`
+### mesenchymal cell `http://purl.obolibrary.org/obo/CL_0008019`
#### Added
-- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata incomplete"@en
+- [mesenchymal cell](http://purl.obolibrary.org/obo/CL_0008019) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata incomplete"@en
+- [mesenchymal cell](http://purl.obolibrary.org/obo/CL_0008019) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en
-- Individual: [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123)
+### mesenchymal stem cell `http://purl.obolibrary.org/obo/CL_0000134`
+#### Removed
+- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-F"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BMSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### microglial cell `http://purl.obolibrary.org/obo/CL_0000129`
-#### Removed
-- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "microglia"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11378515"
#### Added
-- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "microglia"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BMSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### micropylar cell `http://purl.obolibrary.org/obo/CL_0007022`
-#### Removed
-- [micropylar cell](http://purl.obolibrary.org/obo/CL_0007022) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11378515"
-#### Added
-- [micropylar cell](http://purl.obolibrary.org/obo/CL_0007022) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-F"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### middle colic artery `http://purl.obolibrary.org/obo/UBERON_0001196`
+### mesothelial cell of visceral pleura `http://purl.obolibrary.org/obo/CL_1000493`
#### Added
-- [middle colic artery](http://purl.obolibrary.org/obo/UBERON_0001196) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [mesothelial cell of visceral pleura](http://purl.obolibrary.org/obo/CL_1000493) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [middle colic artery](http://purl.obolibrary.org/obo/UBERON_0001196) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [mesothelial cell of visceral pleura](http://purl.obolibrary.org/obo/CL_1000493) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### middle colic vein `http://purl.obolibrary.org/obo/UBERON_0001218`
+### metallothionein-positive alveolar macrophage `http://purl.obolibrary.org/obo/CL_4033042`
#### Added
-- [middle colic vein](http://purl.obolibrary.org/obo/UBERON_0001218) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [middle colic vein](http://purl.obolibrary.org/obo/UBERON_0001218) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### mitogenic signaling cell `http://purl.obolibrary.org/obo/CL_0000422`
-#### Removed
-- [mitogenic signaling cell](http://purl.obolibrary.org/obo/CL_0000422) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### microvillus organization `http://purl.obolibrary.org/obo/GO_0032528`
#### Added
-- [mitogenic signaling cell](http://purl.obolibrary.org/obo/CL_0000422) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [microvillus organization](http://purl.obolibrary.org/obo/GO_0032528) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
+- [microvillus organization](http://purl.obolibrary.org/obo/GO_0032528) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)))
-### monostratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004226`
+
+### monoatomic ion gated channel activity `http://purl.obolibrary.org/obo/GO_0022839`
#### Removed
-- [monostratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004226) EquivalentTo [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [monostratified dendrite cell morphology](http://purl.obolibrary.org/obo/PATO_0070063))
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) [label](http://www.w3.org/2000/01/rdf-schema#label) "monoatomic ion gated channel activity"
+
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_24867](http://purl.obolibrary.org/obo/CHEBI_24867))
-- [monostratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004226) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) SubClassOf [monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005216)
#### Added
-- [monostratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004226) EquivalentTo [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [monostratified dendrite cell morphology](http://purl.obolibrary.org/obo/PATO_0070063))
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) [label](http://www.w3.org/2000/01/rdf-schema#label) "monoatomic ion-gated channel activity"
-- [monostratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004226) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "monoatomic ion gated channel activity"
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24867](http://purl.obolibrary.org/obo/CHEBI_24867))
-### motile cell `http://purl.obolibrary.org/obo/CL_0000219`
+- [monoatomic ion gated channel activity](http://purl.obolibrary.org/obo/GO_0022839) SubClassOf [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_24867](http://purl.obolibrary.org/obo/CHEBI_24867)
+
+
+### monoblast `http://purl.obolibrary.org/obo/CL_0000040`
#### Removed
-- [motile cell](http://purl.obolibrary.org/obo/CL_0000219) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [cell motility](http://purl.obolibrary.org/obo/GO_0048870))
+- [monoblast](http://purl.obolibrary.org/obo/CL_0000040) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-M"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+#### Added
+- [monoblast](http://purl.obolibrary.org/obo/CL_0000040) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-M"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
-- [motile cell](http://purl.obolibrary.org/obo/CL_0000219) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### mononuclear phagocyte `http://purl.obolibrary.org/obo/CL_0000113`
#### Added
-- [motile cell](http://purl.obolibrary.org/obo/CL_0000219) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [cell motility](http://purl.obolibrary.org/obo/GO_0048870))
+- [mononuclear phagocyte](http://purl.obolibrary.org/obo/CL_0000113) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [motile cell](http://purl.obolibrary.org/obo/CL_0000219) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [mononuclear phagocyte](http://purl.obolibrary.org/obo/CL_0000113) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### multi fate stem cell `http://purl.obolibrary.org/obo/CL_0000048`
+### multi-cell-part structure `http://purl.obolibrary.org/obo/CARO_0001000`
#### Removed
-- [multi fate stem cell](http://purl.obolibrary.org/obo/CL_0000048) EquivalentTo [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [multipotent](http://purl.obolibrary.org/obo/PATO_0001402)) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [stem cell division](http://purl.obolibrary.org/obo/GO_0017145))
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
-- [multi fate stem cell](http://purl.obolibrary.org/obo/CL_0000048) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
-
-#### Added
-- [multi fate stem cell](http://purl.obolibrary.org/obo/CL_0000048) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [multipotent](http://purl.obolibrary.org/obo/PATO_0001402)) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [stem cell division](http://purl.obolibrary.org/obo/GO_0017145))
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part."
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0001000"
-### multinucleate cell `http://purl.obolibrary.org/obo/CL_0000228`
-#### Removed
-- [multinucleate cell](http://purl.obolibrary.org/obo/CL_0000228) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [multinucleate](http://purl.obolibrary.org/obo/PATO_0001908))
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) [label](http://www.w3.org/2000/01/rdf-schema#label) "multi-cell-part structure"
-#### Added
-- [multinucleate cell](http://purl.obolibrary.org/obo/CL_0000228) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [multinucleate](http://purl.obolibrary.org/obo/PATO_0001908))
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "multi-cell-component structure"
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Examples: a bundle of neuron projections in the brain; a region neuropil in an arthropod central nervous system; a region of cortex (preikaryal rind) in an arthropod brain."
-### mural cell `http://purl.obolibrary.org/obo/CL_0008034`
-#### Removed
-- [mural cell](http://purl.obolibrary.org/obo/CL_0008034) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- Class: [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000)
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) DisjointWith [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) only (not ([cell](http://purl.obolibrary.org/obo/CARO_0000013)))) and ([has component](http://purl.obolibrary.org/obo/RO_0002180) min 2 [cell part](http://purl.obolibrary.org/obo/CARO_0000014))
-### muscle cell `http://purl.obolibrary.org/obo/CL_0000187`
-#### Removed
-- [muscle cell](http://purl.obolibrary.org/obo/CL_0000187) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) SubClassOf [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008)
-### muscle precursor cell `http://purl.obolibrary.org/obo/CL_0000680`
+### multi-ciliated epithelial cell `http://purl.obolibrary.org/obo/CL_0005012`
#### Removed
-- [muscle precursor cell](http://purl.obolibrary.org/obo/CL_0000680) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [multi-ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_0005012) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MCC"@en
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+#### Added
+- [multi-ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_0005012) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MCC"@en
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### myocyte of sinoatrial node `http://purl.obolibrary.org/obo/CL_1000409`
+### multicellular anatomical structure `http://purl.obolibrary.org/obo/CARO_0010000`
#### Removed
-- [myocyte of sinoatrial node](http://purl.obolibrary.org/obo/CL_1000409) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "myocyte of sinoatrial node"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:67102"
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "djs93"
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An anatomical structure that has more than one cell as a part."
-### named class expression `http://purl.obolibrary.org/obo/IAO_0000421`
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) [label](http://www.w3.org/2000/01/rdf-schema#label) "multicellular anatomical structure"
-#### Added
-- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions"@en
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) [IAO_creation_date](http://purl.obolibrary.org/obo/IAO_creation_date) "Sun Feb 27 10:53:00 GMT 2011"
-- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "named class expression"@en
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0010000"
-- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+- Class: [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) EquivalentTo [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [multicellular](http://purl.obolibrary.org/obo/PATO_0001993))
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"
-- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [label](http://www.w3.org/2000/01/rdf-schema#label) "named class expression"@en
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- Individual: [named class expression](http://purl.obolibrary.org/obo/IAO_0000421)
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) SubClassOf [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008)
+
+- [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [multicellular](http://purl.obolibrary.org/obo/PATO_0001993)
-### native cell `http://purl.obolibrary.org/obo/CL_0000003`
-#### Removed
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [label](http://www.w3.org/2000/01/rdf-schema#label) "native cell"
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12)."
+### multicellular organism `http://purl.obolibrary.org/obo/CARO_0000012`
+#### Removed
+- [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012) [label](http://www.w3.org/2000/01/rdf-schema#label) "multicellular organism"
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CARO:mah"
+- [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities."
-#### Added
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true
+- [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000012"
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "https://github.com/obophenotype/cell-ontology/issues/2124"
+- Class: [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012)
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "OBSOLETE. A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CARO:mah"
+- [multicellular organism](http://purl.obolibrary.org/obo/CARO_0000012) SubClassOf [cellular organism](http://purl.obolibrary.org/obo/CARO_0010004)
-- [native cell](http://purl.obolibrary.org/obo/CL_0000003) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete native cell"
-### nephrocyte `http://purl.obolibrary.org/obo/CL_0002520`
+### muscle cell `http://purl.obolibrary.org/obo/CL_0000187`
#### Removed
-- [nephrocyte](http://purl.obolibrary.org/obo/CL_0002520) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [muscle cell](http://purl.obolibrary.org/obo/CL_0000187) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Muscle_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
#### Added
-- [nephrocyte](http://purl.obolibrary.org/obo/CL_0002520) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [muscle cell](http://purl.obolibrary.org/obo/CL_0000187) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://www.swissbiopics.org/api/image/Muscle_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### neural cell `http://purl.obolibrary.org/obo/CL_0002319`
+### myeloid dendritic cell `http://purl.obolibrary.org/obo/CL_0000782`
#### Removed
-- [neural cell](http://purl.obolibrary.org/obo/CL_0002319) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016))
-
-- [neural cell](http://purl.obolibrary.org/obo/CL_0002319) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [myeloid dendritic cell](http://purl.obolibrary.org/obo/CL_0000782) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-#### Added
-- [neural cell](http://purl.obolibrary.org/obo/CL_0002319) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016))
+- [myeloid dendritic cell](http://purl.obolibrary.org/obo/CL_0000782) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [neural cell](http://purl.obolibrary.org/obo/CL_0002319) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### neural progenitor cell `http://purl.obolibrary.org/obo/CL_0011020`
+### myeloid leukocyte `http://purl.obolibrary.org/obo/CL_0000766`
#### Removed
-- [neural progenitor cell](http://purl.obolibrary.org/obo/CL_0011020) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
+- [myeloid leukocyte](http://purl.obolibrary.org/obo/CL_0000766) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [myeloid leukocyte](http://purl.obolibrary.org/obo/CL_0000766) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### neuroblast (sensu Nematoda and Protostomia) `http://purl.obolibrary.org/obo/CL_0000338`
-
-#### Added
-- [neuroblast (sensu Nematoda and Protostomia)](http://purl.obolibrary.org/obo/CL_0000338) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
-### neuroblast (sensu Vertebrata) `http://purl.obolibrary.org/obo/CL_0000031`
-#### Removed
-- [neuroblast (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000031) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+### nail `http://purl.obolibrary.org/obo/UBERON_0001705`
#### Added
-- [neuroblast (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000031) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [IAO_0000232](http://purl.obolibrary.org/obo/IAO_0000232) "Use this class for both the nails of primates and the homologous claws of mammals such as mouse."
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CALOHA:TS-2034"
-### neuroendocrine gland `http://purl.obolibrary.org/obo/UBERON_0010133`
-#### Removed
-- [neuroendocrine gland](http://purl.obolibrary.org/obo/UBERON_0010133) EquivalentTo [endocrine gland](http://purl.obolibrary.org/obo/UBERON_0002368) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016))
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
-- [neuroendocrine gland](http://purl.obolibrary.org/obo/UBERON_0010133) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-#### Added
-- [neuroendocrine gland](http://purl.obolibrary.org/obo/UBERON_0010133) EquivalentTo [endocrine gland](http://purl.obolibrary.org/obo/UBERON_0002368) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018))
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MIAA:0000158"
-- [neuroendocrine gland](http://purl.obolibrary.org/obo/UBERON_0010133) SubClassOf [overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0000956"
-- [neuroendocrine gland](http://purl.obolibrary.org/obo/UBERON_0010133) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54326"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "A primate's nail consists of the unguis alone; the subunguis has disappeared"
-### neuroendocrine system `http://purl.obolibrary.org/obo/UBERON_8600018`
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C33156"
-#### Added
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuroendocrine system"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://github.com/obophenotype/uberon/issues/120"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In vertebrates, the hypothalamic-pituitary-target organ axis (H-P axis), the autonomic nervous system (ANS) and the diffuse neuroendocrine or APUD system contribute to the neuroendocrine system."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15481802"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nail_(anatomy)"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A regulatory system of the body that integrates the nervous system and the endocrine system. This system is formed by specialized neuroendocrine cells located mainly in the nervous system and neuroendocrine glands. However, they can also be found as either single cells or small clusters of cells dispersed throughout the surface epithelium of different tissues. The neuroendocrine system functions through the release of neurotransmitters and neurohormones, enabling communication between the endocrine and nervous systems to govern vitally important processes that include growth, reproduction, metabolism and energy homeostasis, electrolyte and water balance, and responses to stress."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15481802"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "claw"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/B978-0-12-375097-6.10001-0"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Claw"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17003257"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [label](http://www.w3.org/2000/01/rdf-schema#label) "nail"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:endocrinology"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MAT:0000158"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25905254"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "talon"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [date](http://purl.org/dc/terms/date) "2023-08-29T10:49:45Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "VHOG:0001361"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim)
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NES"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15481802"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nail/claw"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://orcid.org/0000-0002-6601-2165"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [ABBREVIATION](http://purl.obolibrary.org/obo/uberon/core#ABBREVIATION)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001705"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8600018"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0027342"
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Nail"
-- Class: [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GAID:1320"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) SubClassOf [anatomical system](http://purl.obolibrary.org/obo/UBERON_0000467)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001719"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) SubClassOf [overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The nails of humans and the claws are moth are highly similar. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse [PMC3579226]"
-- [neuroendocrine system](http://purl.obolibrary.org/obo/UBERON_8600018) SubClassOf [overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [endocrine system](http://purl.obolibrary.org/obo/UBERON_0000949)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nail_(anatomy)"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D009262"
-### neuroglioblast (sensu Nematoda and Protostomia) `http://purl.obolibrary.org/obo/CL_0000468`
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35580"
-#### Added
-- [neuroglioblast (sensu Nematoda and Protostomia)](http://purl.obolibrary.org/obo/CL_0000468) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EV:0100159"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0002703"
-### neuromast mantle cell `http://purl.obolibrary.org/obo/CL_0000851`
-#### Removed
-- [neuromast mantle cell](http://purl.obolibrary.org/obo/CL_0000851) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "galen:Nail"
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:72651009"
+- Class: [nail](http://purl.obolibrary.org/obo/UBERON_0001705)
-### neuron associated cell (sensu Nematoda and Protostomia) `http://purl.obolibrary.org/obo/CL_0000130`
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) SubClassOf [composed primarily of](http://purl.obolibrary.org/obo/RO_0002473) some [keratin filament](http://purl.obolibrary.org/obo/GO_0045095)
-#### Added
-- [neuron associated cell (sensu Nematoda and Protostomia)](http://purl.obolibrary.org/obo/CL_0000130) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [nail](http://purl.obolibrary.org/obo/UBERON_0001705) SubClassOf [distal limb integumentary appendage](http://purl.obolibrary.org/obo/UBERON_0009564)
-### neuron associated cell (sensu Vertebrata) `http://purl.obolibrary.org/obo/CL_0000123`
+### nail development `http://purl.obolibrary.org/obo/GO_0035878`
#### Added
-- [neuron associated cell (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000123) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-05-31T02:30:34Z"
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0035878"
-### nitrogen fixing cell `http://purl.obolibrary.org/obo/CL_0000725`
-#### Removed
-- [nitrogen fixing cell](http://purl.obolibrary.org/obo/CL_0000725) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [nitrogen fixation](http://purl.obolibrary.org/obo/GO_0009399))
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bf"
-- [nitrogen fixing cell](http://purl.obolibrary.org/obo/CL_0000725) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) [label](http://www.w3.org/2000/01/rdf-schema#label) "nail development"
-#### Added
-- [nitrogen fixing cell](http://purl.obolibrary.org/obo/CL_0000725) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [nitrogen fixation](http://purl.obolibrary.org/obo/GO_0009399))
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [nitrogen fixing cell](http://purl.obolibrary.org/obo/CL_0000725) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0323025781"
-### notochordal cell `http://purl.obolibrary.org/obo/CL_0007005`
-#### Removed
-- [notochordal cell](http://purl.obolibrary.org/obo/CL_0007005) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nail_(anatomy)"
-#### Added
-- [notochordal cell](http://purl.obolibrary.org/obo/CL_0007005) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UBERON:0001705"
+- Class: [nail development](http://purl.obolibrary.org/obo/GO_0035878)
-### nucleate cell `http://purl.obolibrary.org/obo/CL_0002242`
-#### Removed
-- [nucleate cell](http://purl.obolibrary.org/obo/CL_0002242) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [nucleated](http://purl.obolibrary.org/obo/PATO_0002505))
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [nail](http://purl.obolibrary.org/obo/UBERON_0001705))
-- [nucleate cell](http://purl.obolibrary.org/obo/CL_0002242) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [limb development](http://purl.obolibrary.org/obo/GO_0060173)
-#### Added
-- [nucleate cell](http://purl.obolibrary.org/obo/CL_0002242) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [nucleated](http://purl.obolibrary.org/obo/PATO_0002505))
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [nail](http://purl.obolibrary.org/obo/UBERON_0001705)
-- [nucleate cell](http://purl.obolibrary.org/obo/CL_0002242) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [nail development](http://purl.obolibrary.org/obo/GO_0035878) SubClassOf [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856)
-### obsolescence reason specification `http://purl.obolibrary.org/obo/IAO_0000225`
+### nail of manual digit `http://purl.obolibrary.org/obo/UBERON_0009565`
#### Added
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Melanie Courtot"@en
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54327"
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "claw of manus"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:244197001"
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolescence reason specification"@en
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35349"
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "obsolescence reason specification"@en
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0222001"
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Fingernail"
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology."@en
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "manual claw"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-- Class: [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) EquivalentTo {[failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) , [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) , [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) , [term imported](http://purl.obolibrary.org/obo/IAO_0000228) , [term split](http://purl.obolibrary.org/obo/IAO_0000229) , [out of scope](http://purl.obolibrary.org/obo/OMO_0001000)}
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [label](http://www.w3.org/2000/01/rdf-schema#label) "nail of manual digit"
-- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C32609"
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nail of finger"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54327"
-### oenocyte `http://purl.obolibrary.org/obo/CL_0000487`
-#### Removed
-- [oenocyte](http://purl.obolibrary.org/obo/CL_0000487) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "fingernail"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54327"
-#### Added
-- [oenocyte](http://purl.obolibrary.org/obo/CL_0000487) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A nail that is part of a manual digit."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0009565"
-### olfactory bulb `http://purl.obolibrary.org/obo/UBERON_0002264`
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "forelimb digit claw"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-#### Added
-- [olfactory bulb](http://purl.obolibrary.org/obo/UBERON_0002264) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35349"
-- [olfactory bulb](http://purl.obolibrary.org/obo/UBERON_0002264) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "claw of hand"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nail plate of finger"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54327"
-### oocyte `http://purl.obolibrary.org/obo/CL_0000023`
-#### Removed
-- [oocyte](http://purl.obolibrary.org/obo/CL_0000023) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "finger nail"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54327"
-#### Added
-- [oocyte](http://purl.obolibrary.org/obo/CL_0000023) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208)
+- Class: [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565)
-- [oocyte](http://purl.obolibrary.org/obo/CL_0000023) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) EquivalentTo [nail](http://purl.obolibrary.org/obo/UBERON_0001705) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [manual digit](http://purl.obolibrary.org/obo/UBERON_0002389))
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal skin of finger](http://purl.obolibrary.org/obo/UBERON_0005276)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
-### oogonial cell `http://purl.obolibrary.org/obo/CL_0000024`
-#### Removed
-- [oogonial cell](http://purl.obolibrary.org/obo/CL_0000024) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [distal segment of manual digit](http://purl.obolibrary.org/obo/UBERON_0009552)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"
+- [nail of manual digit](http://purl.obolibrary.org/obo/UBERON_0009565) SubClassOf [nail](http://purl.obolibrary.org/obo/UBERON_0001705)
-### ophthalmic artery `http://purl.obolibrary.org/obo/UBERON_0001619`
+### nail of pedal digit `http://purl.obolibrary.org/obo/UBERON_0009567`
#### Added
-- [ophthalmic artery](http://purl.obolibrary.org/obo/UBERON_0001619) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C33790"
-- [ophthalmic artery](http://purl.obolibrary.org/obo/UBERON_0001619) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "XAO:0003103"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0009567"
-### ophthalmic vein `http://purl.obolibrary.org/obo/UBERON_0011191`
-
-#### Added
-- [ophthalmic vein](http://purl.obolibrary.org/obo/UBERON_0011191) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "claw of foot"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-- [ophthalmic vein](http://purl.obolibrary.org/obo/UBERON_0011191) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [label](http://www.w3.org/2000/01/rdf-schema#label) "nail of pedal digit"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "toe nail"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54328"
-### optic tract `http://purl.obolibrary.org/obo/UBERON_0001908`
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0222007"
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Toe_Nail"
-#### Added
-- [optic tract](http://purl.obolibrary.org/obo/UBERON_0001908) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "hindlimb claw"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-- [optic tract](http://purl.obolibrary.org/obo/UBERON_0001908) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:36457"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nail plate of toe"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54328"
-### organizational term `http://purl.obolibrary.org/obo/IAO_0000121`
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-#### Added
-- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [label](http://www.w3.org/2000/01/rdf-schema#label) "organizational term"@en
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:36457"
-- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "organizational term"@en
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54328"
-- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "pedal claw"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-- Individual: [organizational term](http://purl.obolibrary.org/obo/IAO_0000121)
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "claw of pes"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-### osteocyte `http://purl.obolibrary.org/obo/CL_0000137`
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nail of toe"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54328"
-#### Added
-- [osteocyte](http://purl.obolibrary.org/obo/CL_0000137) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320)
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "hindlimb digit claw"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A nail that is part of a pedal digit."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
-### out of scope `http://purl.obolibrary.org/obo/OMO_0001000`
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:244198006"
-#### Added
-- [out of scope](http://purl.obolibrary.org/obo/OMO_0001000) [IAO_0000234](http://purl.obolibrary.org/obo/IAO_0000234) "https://orcid.org/0000-0001-5208-3432"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "claw of toe"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [SENSU](http://purl.obolibrary.org/obo/uberon/core#SENSU)
-- [out of scope](http://purl.obolibrary.org/obo/OMO_0001000) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This obsolesence reason should be used conservatively. Typical valid examples are: un-necessary grouping classes in disease ontologies, a phenotype term added on the assumption it was a disease."@en
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "toenail"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:54328"
-- [out of scope](http://purl.obolibrary.org/obo/OMO_0001000) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) [0000-0001-5208-3432](http://orcid.org/0000-0001-5208-3432)
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nail of pes"
-- [out of scope](http://purl.obolibrary.org/obo/OMO_0001000) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The term was added to the ontology on the assumption it was in scope, but it turned out later that it was not."@en
+- Class: [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567)
-- [out of scope](http://purl.obolibrary.org/obo/OMO_0001000) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/information-artifact-ontology/ontology-metadata/issues/77"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) EquivalentTo [nail](http://purl.obolibrary.org/obo/UBERON_0001705) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pedal digit](http://purl.obolibrary.org/obo/UBERON_0001466))
-- [out of scope](http://purl.obolibrary.org/obo/OMO_0001000) [label](http://www.w3.org/2000/01/rdf-schema#label) "out of scope"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) SubClassOf [nail](http://purl.obolibrary.org/obo/UBERON_0001705)
-- Individual: [out of scope](http://purl.obolibrary.org/obo/OMO_0001000)
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal skin of toe](http://purl.obolibrary.org/obo/UBERON_0005277)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
+- [nail of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009567) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [distal segment of pedal digit](http://purl.obolibrary.org/obo/UBERON_0009553)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"
-### oxygen accumulating cell `http://purl.obolibrary.org/obo/CL_0000329`
-#### Removed
-- [oxygen accumulating cell](http://purl.obolibrary.org/obo/CL_0000329) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [oxygen transport](http://purl.obolibrary.org/obo/GO_0015671))
-- [oxygen accumulating cell](http://purl.obolibrary.org/obo/CL_0000329) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### nail plate `http://purl.obolibrary.org/obo/UBERON_0008198`
#### Added
-- [oxygen accumulating cell](http://purl.obolibrary.org/obo/CL_0000329) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [oxygen transport](http://purl.obolibrary.org/obo/GO_0015671))
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35583"
-- [oxygen accumulating cell](http://purl.obolibrary.org/obo/CL_0000329) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [UBPROP_0000012](http://purl.obolibrary.org/obo/UBPROP_0000012) "in FMA, the nail is the nail plate"
+ - [external_ontology](http://www.geneontology.org/formats/oboInOwl#external_ontology) "FMA"
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [label](http://www.w3.org/2000/01/rdf-schema#label) "nail plate"
-### pancreas `http://purl.obolibrary.org/obo/UBERON_0001264`
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-#### Added
-- [pancreas](http://purl.obolibrary.org/obo/UBERON_0001264) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Pancreas.glb"
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [pancreas](http://purl.obolibrary.org/obo/UBERON_0001264) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Pancreas.glb"
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C34216"
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### paracrine cell `http://purl.obolibrary.org/obo/CL_0000512`
-#### Removed
-- [paracrine cell](http://purl.obolibrary.org/obo/CL_0000512) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0008198"
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nail_plate"
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0002708"
-### paraganglia type 2 cell `http://purl.obolibrary.org/obo/CL_0000701`
-#### Removed
-- [paraganglia type 2 cell](http://purl.obolibrary.org/obo/CL_0000701) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lamina unguis"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nail_plate"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The nail plate is the hard and translucent portion of the nail, composed of keratin."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://github.com/obophenotype/uberon/issues/20"
-### pending final vetting `http://purl.obolibrary.org/obo/IAO_0000125`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nail_plate"
-#### Added
-- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://sourceforge.net/p/geneontology/ontology-requests/8479/"
-- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "pending final vetting"@en
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://upload.wikimedia.org/wikipedia/commons/9/9f/Fingernail_label.jpg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [label](http://www.w3.org/2000/01/rdf-schema#label) "pending final vetting"@en
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:372177002"
-- Individual: [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+- Class: [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) SubClassOf [integumentary system layer](http://purl.obolibrary.org/obo/UBERON_0013754)
-### pericardial cavity `http://purl.obolibrary.org/obo/UBERON_0001074`
-#### Removed
-- [pericardial cavity](http://purl.obolibrary.org/obo/UBERON_0001074) SubClassOf [contains](http://purl.obolibrary.org/obo/RO_0001019) some [pericardial fluid](http://purl.obolibrary.org/obo/UBERON_0002409)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [keratinocyte](http://purl.obolibrary.org/obo/CL_0000312)
-#### Added
-- [pericardial cavity](http://purl.obolibrary.org/obo/UBERON_0001074) SubClassOf [location of](http://purl.obolibrary.org/obo/RO_0001015) some [pericardial fluid](http://purl.obolibrary.org/obo/UBERON_0002409)
+- [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nail](http://purl.obolibrary.org/obo/UBERON_0001705)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
-### peridermal cell `http://purl.obolibrary.org/obo/CL_0000078`
+### natural killer cell degranulation `http://purl.obolibrary.org/obo/GO_0043320`
#### Removed
-- [peridermal cell](http://purl.obolibrary.org/obo/CL_0000078) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [natural killer cell degranulation](http://purl.obolibrary.org/obo/GO_0043320) SubClassOf [natural killer cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002323)
+#### Added
+- [natural killer cell degranulation](http://purl.obolibrary.org/obo/GO_0043320) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [natural killer cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002323)
-### periglomerular cell `http://purl.obolibrary.org/obo/CL_1001435`
+### negative regulation of acetylcholine biosynthetic process `http://purl.obolibrary.org/obo/GO_1905922`
#### Removed
-- [periglomerular cell](http://purl.obolibrary.org/obo/CL_1001435) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "periglomerular cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIFEXT:122"
+- [negative regulation of acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_1905922) SubClassOf [negative regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031327)
+#### Added
+- [negative regulation of acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_1905922) SubClassOf [negative regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009890)
-### perivascular cell `http://purl.obolibrary.org/obo/CL_4033054`
+### negative regulation of acetylcholine metabolic process `http://purl.obolibrary.org/obo/GO_0060410`
#### Removed
-- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([adjacent to](http://purl.obolibrary.org/obo/RO_0002220) some [vasculature](http://purl.obolibrary.org/obo/UBERON_0002049))
-
-- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
-
-#### Added
-- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([adjacent to](http://purl.obolibrary.org/obo/RO_0002220) some [vasculature](http://purl.obolibrary.org/obo/UBERON_0002049))
+- [negative regulation of acetylcholine metabolic process](http://purl.obolibrary.org/obo/GO_0060410) SubClassOf [negative regulation of cellular metabolic process](http://purl.obolibrary.org/obo/GO_0031324)
-- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### perivascular space `http://purl.obolibrary.org/obo/UBERON_0014930`
+### negative regulation of basophil degranulation `http://purl.obolibrary.org/obo/GO_1903582`
#### Removed
-- [perivascular space](http://purl.obolibrary.org/obo/UBERON_0014930) SubClassOf [contains](http://purl.obolibrary.org/obo/RO_0001019) some [cerebrospinal fluid](http://purl.obolibrary.org/obo/UBERON_0001359)
-
-#### Added
-- [perivascular space](http://purl.obolibrary.org/obo/UBERON_0014930) SubClassOf [location of](http://purl.obolibrary.org/obo/RO_0001015) some [cerebrospinal fluid](http://purl.obolibrary.org/obo/UBERON_0001359)
+- [negative regulation of basophil degranulation](http://purl.obolibrary.org/obo/GO_1903582) SubClassOf [negative regulation of leukocyte activation](http://purl.obolibrary.org/obo/GO_0002695)
-### phagocyte `http://purl.obolibrary.org/obo/CL_0000234`
-#### Removed
-- [phagocyte](http://purl.obolibrary.org/obo/CL_0000234) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [phagocytosis](http://purl.obolibrary.org/obo/GO_0006909))
-- [phagocyte](http://purl.obolibrary.org/obo/CL_0000234) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+### negative regulation of blood vessel remodeling `http://purl.obolibrary.org/obo/GO_0060313`
#### Added
-- [phagocyte](http://purl.obolibrary.org/obo/CL_0000234) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [phagocytosis](http://purl.obolibrary.org/obo/GO_0006909))
+- [negative regulation of blood vessel remodeling](http://purl.obolibrary.org/obo/GO_0060313) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of blood vessel remodelling"
-### phagocyte (sensu Vertebrata) `http://purl.obolibrary.org/obo/CL_0000518`
+### negative regulation of bone remodeling `http://purl.obolibrary.org/obo/GO_0046851`
#### Added
-- [phagocyte (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000518) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [negative regulation of bone remodeling](http://purl.obolibrary.org/obo/GO_0046851) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of bone remodelling"
-### photosynthetic cell `http://purl.obolibrary.org/obo/CL_0000628`
-#### Removed
-- [photosynthetic cell](http://purl.obolibrary.org/obo/CL_0000628) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### negative regulation of cell population proliferation `http://purl.obolibrary.org/obo/GO_0008285`
#### Added
-- [photosynthetic cell](http://purl.obolibrary.org/obo/CL_0000628) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [negative regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0008285) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
+
+- [negative regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0008285) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)))
-### pigment cell (sensu Nematoda and Protostomia) `http://purl.obolibrary.org/obo/CL_0000341`
+### negative regulation of cytotoxic T cell degranulation `http://purl.obolibrary.org/obo/GO_0043318`
#### Removed
-- [pigment cell (sensu Nematoda and Protostomia)](http://purl.obolibrary.org/obo/CL_0000341) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [negative regulation of cytotoxic T cell degranulation](http://purl.obolibrary.org/obo/GO_0043318) SubClassOf [negative regulation of T cell activation](http://purl.obolibrary.org/obo/GO_0050868)
-### pigment cell (sensu Vertebrata) `http://purl.obolibrary.org/obo/CL_0000342`
+### negative regulation of eosinophil degranulation `http://purl.obolibrary.org/obo/GO_0043310`
#### Removed
-- [pigment cell (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000342) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [negative regulation of eosinophil degranulation](http://purl.obolibrary.org/obo/GO_0043310) SubClassOf [negative regulation of eosinophil activation](http://purl.obolibrary.org/obo/GO_1902567)
-#### Added
-- [pigment cell (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000342) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
-### pigment erythroblast `http://purl.obolibrary.org/obo/CL_0005004`
+### negative regulation of mast cell degranulation `http://purl.obolibrary.org/obo/GO_0043305`
#### Removed
-- [pigment erythroblast](http://purl.obolibrary.org/obo/CL_0005004) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
+- [negative regulation of mast cell degranulation](http://purl.obolibrary.org/obo/GO_0043305) SubClassOf [negative regulation of mast cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0033007)
-### pineal body `http://purl.obolibrary.org/obo/UBERON_0001905`
-#### Added
-- [pineal body](http://purl.obolibrary.org/obo/UBERON_0001905) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
-
-- [pineal body](http://purl.obolibrary.org/obo/UBERON_0001905) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+### negative regulation of natural killer cell degranulation `http://purl.obolibrary.org/obo/GO_0043322`
+#### Removed
+- [negative regulation of natural killer cell degranulation](http://purl.obolibrary.org/obo/GO_0043322) SubClassOf [negative regulation of natural killer cell activation](http://purl.obolibrary.org/obo/GO_0032815)
-### piriform cortex `http://purl.obolibrary.org/obo/UBERON_0004725`
-#### Added
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+### negative regulation of neutrophil degranulation `http://purl.obolibrary.org/obo/GO_0043314`
+#### Removed
+- [negative regulation of neutrophil degranulation](http://purl.obolibrary.org/obo/GO_0043314) SubClassOf [negative regulation of neutrophil activation](http://purl.obolibrary.org/obo/GO_1902564)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
-### pituitary gland `http://purl.obolibrary.org/obo/UBERON_0000007`
+### negative regulation of pharynx morphogenesis `http://purl.obolibrary.org/obo/GO_0110042`
#### Removed
-- [pituitary gland](http://purl.obolibrary.org/obo/UBERON_0000007) SubClassOf [neuroendocrine gland](http://purl.obolibrary.org/obo/UBERON_0010133)
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0110042"
-#### Added
-- [pituitary gland](http://purl.obolibrary.org/obo/UBERON_0000007) SubClassOf [endocrine gland](http://purl.obolibrary.org/obo/UBERON_0002368)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BTO"
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-07-24T21:05:08Z"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "VHOG"
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of pharynx morphogenesis"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "EFO"
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
-### pituitary gland cell `http://purl.obolibrary.org/obo/CL_2000004`
-#### Removed
-- [pituitary gland cell](http://purl.obolibrary.org/obo/CL_2000004) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pituitary gland](http://purl.obolibrary.org/obo/UBERON_0000007))
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of pharynx morphogenesis."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rz"
-#### Added
-- [pituitary gland cell](http://purl.obolibrary.org/obo/CL_2000004) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pituitary gland](http://purl.obolibrary.org/obo/UBERON_0000007))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20805556"
+- Class: [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042)
-### placeholder removed `http://purl.obolibrary.org/obo/IAO_0000226`
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040))
-#### Added
-- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "placeholder removed"@en
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) SubClassOf [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041)
+
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) SubClassOf [negative regulation of developmental process](http://purl.obolibrary.org/obo/GO_0051093)
-- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [label](http://www.w3.org/2000/01/rdf-schema#label) "placeholder removed"@en
+- [negative regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110042) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040)
-- Individual: [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226)
-### placenta `http://purl.obolibrary.org/obo/UBERON_0001987`
+### negative regulation of pulmonary blood vessel remodeling `http://purl.obolibrary.org/obo/GO_1905110`
#### Added
-- [placenta](http://purl.obolibrary.org/obo/UBERON_0001987) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb"
+- [negative regulation of pulmonary blood vessel remodeling](http://purl.obolibrary.org/obo/GO_1905110) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of pulmonary blood vessel remodelling"
-### plural form `http://purl.obolibrary.org/obo/OMO_0003004`
+### negative regulation of tissue remodeling `http://purl.obolibrary.org/obo/GO_0034104`
#### Added
-- [plural form](http://purl.obolibrary.org/obo/OMO_0003004) [label](http://www.w3.org/2000/01/rdf-schema#label) "plural form"
+- [negative regulation of tissue remodeling](http://purl.obolibrary.org/obo/GO_0034104) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of tissue remodelling"
-- [plural form](http://purl.obolibrary.org/obo/OMO_0003004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A synonym type for describing pluralization synonyms"
-- [plural form](http://purl.obolibrary.org/obo/OMO_0003004) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "CHEBI:23367 (molecular entity) has an exact synonym (molecular entities), which is of the type OMO:0003004 (plural form)"
+### negatively regulates `http://purl.obolibrary.org/obo/RO_0002212`
+#### Removed
+- [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "gene_ontology"
-- [plural form](http://purl.obolibrary.org/obo/OMO_0003004) [created](http://purl.org/dc/terms/created) "2023-03-03"^^[date](http://www.w3.org/2001/XMLSchema#date)
-- [plural form](http://purl.obolibrary.org/obo/OMO_0003004) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [122](https://github.com/information-artifact-ontology/ontology-metadata/issues/122)
-- [plural form](http://purl.obolibrary.org/obo/OMO_0003004) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-4423-4370](https://orcid.org/0000-0003-4423-4370)
+### neuron `http://purl.obolibrary.org/obo/CL_0000540`
+#### Removed
+- [neuron](http://purl.obolibrary.org/obo/CL_0000540) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Neuron_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- AnnotationProperty: [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+#### Added
+- [neuron](http://purl.obolibrary.org/obo/CL_0000540) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://www.swissbiopics.org/api/image/Neuron_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### plural term `http://purl.obolibrary.org/obo/uberon/core#PLURAL`
+### neurotransmitter binding `http://purl.obolibrary.org/obo/GO_0042165`
#### Removed
-- [plural term](http://purl.obolibrary.org/obo/uberon/core#PLURAL) [label](http://www.w3.org/2000/01/rdf-schema#label) "plural term"
+- [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir)
+- [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
+- [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042165"
-### polar body `http://purl.obolibrary.org/obo/CL_0002090`
-#### Removed
-- [polar body](http://purl.obolibrary.org/obo/CL_0002090) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165) [label](http://www.w3.org/2000/01/rdf-schema#label) "neurotransmitter binding"
+- [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+- Class: [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165)
-### polyploid `http://purl.obolibrary.org/obo/PATO_0001377`
+- [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
-#### Added
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) [label](http://www.w3.org/2000/01/rdf-schema#label) "polyploid"
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "quality"
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [value_slim](http://purl.obolibrary.org/obo/pato#value_slim)
+### neurotransmitter biosynthetic process `http://purl.obolibrary.org/obo/GO_0042136`
+#### Removed
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter synthesis"
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) [id](http://www.geneontology.org/formats/oboInOwl#id) "PATO:0001377"
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse)
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [cell_quality](http://purl.obolibrary.org/obo/pato#cell_quality)
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter anabolism"
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:http://en.wikipedia.org/wiki/Polyploid"
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
-- Class: [polyploid](http://purl.obolibrary.org/obo/PATO_0001377)
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "neurotransmitter biosynthesis and storage"
-- [polyploid](http://purl.obolibrary.org/obo/PATO_0001377) SubClassOf [euploid](http://purl.obolibrary.org/obo/PATO_0001393)
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042136"
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-### polyploid cell `http://purl.obolibrary.org/obo/CL_0000412`
-#### Removed
-- [polyploid cell](http://purl.obolibrary.org/obo/CL_0000412) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell whose nucleus, or nuclei, each contain more than two haploid genomes."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FB:ma"
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [label](http://www.w3.org/2000/01/rdf-schema#label) "neurotransmitter biosynthetic process"
-- [polyploid cell](http://purl.obolibrary.org/obo/CL_0000412) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter biosynthesis"
-#### Added
-- [polyploid cell](http://purl.obolibrary.org/obo/CL_0000412) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that contains more than two haploid sets of chromosomes."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "neurotransmitter biosynthetic process and storage"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32646579"
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter formation"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FB:ma"
+- Class: [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136)
-- [polyploid cell](http://purl.obolibrary.org/obo/CL_0000412) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [polyploid](http://purl.obolibrary.org/obo/PATO_0001377))
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) SubClassOf [cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0044249)
-- [polyploid cell](http://purl.obolibrary.org/obo/CL_0000412) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [neurotransmitter biosynthetic process](http://purl.obolibrary.org/obo/GO_0042136) SubClassOf [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133)
-- [polyploid cell](http://purl.obolibrary.org/obo/CL_0000412) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [polyploid](http://purl.obolibrary.org/obo/PATO_0001377)
-### pontine tegmentum `http://purl.obolibrary.org/obo/UBERON_0003023`
+### neurotransmitter catabolic process `http://purl.obolibrary.org/obo/GO_0042135`
+#### Removed
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042135"
-#### Added
-- [pontine tegmentum](http://purl.obolibrary.org/obo/UBERON_0003023) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
-- [pontine tegmentum](http://purl.obolibrary.org/obo/UBERON_0003023) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter breakdown"
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse)
-### posterior lateral line neuromast supporting cell `http://purl.obolibrary.org/obo/CL_2000039`
-#### Removed
-- [posterior lateral line neuromast supporting cell](http://purl.obolibrary.org/obo/CL_2000039) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter degradation"
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter catabolism"
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [label](http://www.w3.org/2000/01/rdf-schema#label) "neurotransmitter catabolic process"
-### preameloblast `http://purl.obolibrary.org/obo/CL_0007000`
-#### Removed
-- [preameloblast](http://purl.obolibrary.org/obo/CL_0007000) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- Class: [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135)
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) SubClassOf [cellular catabolic process](http://purl.obolibrary.org/obo/GO_0044248)
-### precementoblast `http://purl.obolibrary.org/obo/CL_0007002`
-#### Removed
-- [precementoblast](http://purl.obolibrary.org/obo/CL_0007002) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [neurotransmitter catabolic process](http://purl.obolibrary.org/obo/GO_0042135) SubClassOf [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133)
-### prechondroblast `http://purl.obolibrary.org/obo/CL_0007009`
+### neurotransmitter metabolic process `http://purl.obolibrary.org/obo/GO_0042133`
#### Removed
-- [prechondroblast](http://purl.obolibrary.org/obo/CL_0007009) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir)
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [never_in_taxon](http://purl.obolibrary.org/obo/RO_0002161) [Schizosaccharomyces](http://purl.obolibrary.org/obo/NCBITaxon_4895)
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
-### precursor cell `http://purl.obolibrary.org/obo/CL_0011115`
-#### Removed
-- [precursor cell](http://purl.obolibrary.org/obo/CL_0011115) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [cell differentiation](http://purl.obolibrary.org/obo/GO_0030154))
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter metabolism"
-- [precursor cell](http://purl.obolibrary.org/obo/CL_0011115) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [label](http://www.w3.org/2000/01/rdf-schema#label) "neurotransmitter metabolic process"
-#### Added
-- [precursor cell](http://purl.obolibrary.org/obo/CL_0011115) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [cell differentiation](http://purl.obolibrary.org/obo/GO_0030154))
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [precursor cell](http://purl.obolibrary.org/obo/CL_0011115) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042133"
+- Class: [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133)
-### preferred_root `http://purl.obolibrary.org/obo/IAO_0000700`
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) DisjointWith [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Schizosaccharomyces](http://purl.obolibrary.org/obo/NCBITaxon_4895)
-#### Added
-- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [label](http://www.w3.org/2000/01/rdf-schema#label) "has ontology root term"@en
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) SubClassOf [cellular metabolic process](http://purl.obolibrary.org/obo/GO_0044237)
-- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has ontology root term"@en
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Schizosaccharomyces](http://purl.obolibrary.org/obo/NCBITaxon_4895))
-- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en
+- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Schizosaccharomyces](http://purl.obolibrary.org/obo/NCBITaxon_4895)))
-- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Nicolas Matentzoglu"@en
-### preodontoblast `http://purl.obolibrary.org/obo/CL_0007003`
+### neurotransmitter receptor activity `http://purl.obolibrary.org/obo/GO_0030594`
#### Removed
-- [preodontoblast](http://purl.obolibrary.org/obo/CL_0007003) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [neurotransmitter receptor activity](http://purl.obolibrary.org/obo/GO_0030594) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165)
-### preosteoblast `http://purl.obolibrary.org/obo/CL_0007010`
+### neurotransmitter secretion `http://purl.obolibrary.org/obo/GO_0007269`
+#### Removed
+- [neurotransmitter secretion](http://purl.obolibrary.org/obo/GO_0007269) SubClassOf [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505)
-#### Added
-- [preosteoblast](http://purl.obolibrary.org/obo/CL_0007010) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320)
-### primary lymphoid nodule of tonsil `http://purl.obolibrary.org/obo/UBERON_0010423`
+### neurotransmitter uptake `http://purl.obolibrary.org/obo/GO_0001504`
#### Removed
-- [primary lymphoid nodule of tonsil](http://purl.obolibrary.org/obo/UBERON_0010423) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) SubClassOf [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505)
-- [primary lymphoid nodule of tonsil](http://purl.obolibrary.org/obo/UBERON_0010423) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-
-### primary neuron (sensu Teleostei) `http://purl.obolibrary.org/obo/CL_0000530`
+### neutrophil degranulation `http://purl.obolibrary.org/obo/GO_0043312`
+#### Removed
+- [neutrophil degranulation](http://purl.obolibrary.org/obo/GO_0043312) SubClassOf [neutrophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002283)
#### Added
-- [primary neuron (sensu Teleostei)](http://purl.obolibrary.org/obo/CL_0000530) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [neutrophil degranulation](http://purl.obolibrary.org/obo/GO_0043312) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [neutrophil activation involved in immune response](http://purl.obolibrary.org/obo/GO_0002283)
-### primary spermatocyte `http://purl.obolibrary.org/obo/CL_0000656`
+### non-membrane-bounded organelle `http://purl.obolibrary.org/obo/GO_0043228`
#### Removed
-- [primary spermatocyte](http://purl.obolibrary.org/obo/CL_0000656) SubClassOf [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [non-membrane-bounded organelle](http://purl.obolibrary.org/obo/GO_0043228) [has narrow synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "biological condensate"
#### Added
-- [primary spermatocyte](http://purl.obolibrary.org/obo/CL_0000656) SubClassOf [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017)
+- [non-membrane-bounded organelle](http://purl.obolibrary.org/obo/GO_0043228) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "biological condensate"
-### primordial germ cell `http://purl.obolibrary.org/obo/CL_0000670`
+### non-striated muscle cell `http://purl.obolibrary.org/obo/CL_0008000`
#### Removed
-- [primordial germ cell](http://purl.obolibrary.org/obo/CL_0000670) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
+- [non-striated muscle cell](http://purl.obolibrary.org/obo/CL_0008000) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-
-### progenitor cell of endocrine pancreas `http://purl.obolibrary.org/obo/CL_0002351`
-#### Removed
-- [progenitor cell of endocrine pancreas](http://purl.obolibrary.org/obo/CL_0002351) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [non-striated muscle cell](http://purl.obolibrary.org/obo/CL_0008000) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### progenitor cell of mammary luminal epithelium `http://purl.obolibrary.org/obo/CL_0009116`
+### normal mass `http://purl.obolibrary.org/obo/PATO_0045030`
#### Removed
-- [progenitor cell of mammary luminal epithelium](http://purl.obolibrary.org/obo/CL_0009116) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [value_slim](http://purl.obolibrary.org/obo/pato#value_slim)
-### prokaryotic cell `http://purl.obolibrary.org/obo/CL_0000520`
-#### Removed
-- [prokaryotic cell](http://purl.obolibrary.org/obo/CL_0000520) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A mass which is relatively normal or average."
-#### Added
-- [prokaryotic cell](http://purl.obolibrary.org/obo/CL_0000520) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-9227-0670](https://orcid.org/0000-0001-9227-0670)
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "quality"
-### prostate duct `http://purl.obolibrary.org/obo/UBERON_0002485`
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [id](http://www.geneontology.org/formats/oboInOwl#id) "PATO:0045030"
-#### Added
-- [prostate duct](http://purl.obolibrary.org/obo/UBERON_0002485) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb"
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-12-22T14:16:43Z"
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) [label](http://www.w3.org/2000/01/rdf-schema#label) "normal mass"
-### prostate gland `http://purl.obolibrary.org/obo/UBERON_0002367`
+- Class: [normal mass](http://purl.obolibrary.org/obo/PATO_0045030)
-#### Added
-- [prostate gland](http://purl.obolibrary.org/obo/UBERON_0002367) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb"
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) EquivalentTo [mass](http://purl.obolibrary.org/obo/PATO_0000125) and ([has relative magnitude](http://purl.obolibrary.org/obo/RO_0015010) some [normal](http://purl.obolibrary.org/obo/PATO_0000461))
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) SubClassOf [normal object quality](http://purl.obolibrary.org/obo/PATO_0045001)
-### prostatic urethra `http://purl.obolibrary.org/obo/UBERON_0001335`
+- [normal mass](http://purl.obolibrary.org/obo/PATO_0045030) SubClassOf [mass](http://purl.obolibrary.org/obo/PATO_0000125)
-#### Added
-- [prostatic urethra](http://purl.obolibrary.org/obo/UBERON_0001335) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urethra.glb"
-### pulmonary acinus `http://purl.obolibrary.org/obo/UBERON_0008874`
+### nuclear estrogen receptor binding `http://purl.obolibrary.org/obo/GO_0030331`
#### Added
-- [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
-
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to a nuclear estrogen receptor."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
-### pulmonary artery `http://purl.obolibrary.org/obo/UBERON_0002012`
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0030331"
-#### Added
-- [pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0002012) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) [label](http://www.w3.org/2000/01/rdf-schema#label) "nuclear estrogen receptor binding"
-- [pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0002012) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-- [pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0002012) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/16717"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0002012) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "estrogen receptor binding"
+- Class: [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331)
-### pulmonary trunk `http://purl.obolibrary.org/obo/UBERON_0002333`
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) EquivalentTo [binding](http://purl.obolibrary.org/obo/GO_0005488) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204))
-#### Added
-- [pulmonary trunk](http://purl.obolibrary.org/obo/UBERON_0002333) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) SubClassOf [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922)
-- [pulmonary trunk](http://purl.obolibrary.org/obo/UBERON_0002333) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [nuclear estrogen receptor binding](http://purl.obolibrary.org/obo/GO_0030331) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [estrogen receptor](http://purl.obolibrary.org/obo/PR_000007204)
-### pulmonary vascular system `http://purl.obolibrary.org/obo/UBERON_0008886`
+### nuclear receptor binding `http://purl.obolibrary.org/obo/GO_0016922`
#### Added
-- [pulmonary vascular system](http://purl.obolibrary.org/obo/UBERON_0008886) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "steroid hormone receptor binding"
-- [pulmonary vascular system](http://purl.obolibrary.org/obo/UBERON_0008886) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016922"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-### pulmonary vein `http://purl.obolibrary.org/obo/UBERON_0002016`
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [label](http://www.w3.org/2000/01/rdf-schema#label) "nuclear receptor binding"
-#### Added
-- [pulmonary vein](http://purl.obolibrary.org/obo/UBERON_0002016) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ligand-dependent nuclear receptor binding"
-- [pulmonary vein](http://purl.obolibrary.org/obo/UBERON_0002016) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0035257"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:7776974"
-### pyramidal neuron `http://purl.obolibrary.org/obo/CL_0000598`
-#### Removed
-- [pyramidal neuron](http://purl.obolibrary.org/obo/CL_0000598) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "pyramidal neuron"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0035258"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nuclear hormone receptor binding"
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ligand-dependent nuclear receptor interactor activity"
-### ready for release `http://purl.obolibrary.org/obo/IAO_0000122`
+- Class: [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922)
-#### Added
-- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "ready for release"@en
+- [nuclear receptor binding](http://purl.obolibrary.org/obo/GO_0016922) SubClassOf [RNA polymerase II-specific DNA-binding transcription factor binding](http://purl.obolibrary.org/obo/GO_0061629)
-- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [label](http://www.w3.org/2000/01/rdf-schema#label) "ready for release"@en
-- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release.""@en
+### nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030051`
+#### Removed
+- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1Sh"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- Individual: [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NAc shell and OT D1-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### rectum `http://purl.obolibrary.org/obo/UBERON_0001052`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
#### Added
-- [rectum](http://purl.obolibrary.org/obo/UBERON_0001052) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1Sh"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [rectum](http://purl.obolibrary.org/obo/UBERON_0001052) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NAc shell and OT D1-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### recurving diffuse amacrine cell `http://purl.obolibrary.org/obo/CL_0004231`
-#### Removed
-- [recurving diffuse amacrine cell](http://purl.obolibrary.org/obo/CL_0004231) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [recurving diffuse amacrine cell](http://purl.obolibrary.org/obo/CL_0004231) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
+### nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030052`
+#### Removed
+- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus accumbens shell and olfactory tubercle D2-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### renal artery `http://purl.obolibrary.org/obo/UBERON_0001184`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-#### Added
-- [renal artery](http://purl.obolibrary.org/obo/UBERON_0001184) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NAc shell and OT D2-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [renal artery](http://purl.obolibrary.org/obo/UBERON_0001184) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2Sh"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### renal lymph node `http://purl.obolibrary.org/obo/UBERON_0003425`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
#### Added
-- [renal lymph node](http://purl.obolibrary.org/obo/UBERON_0003425) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "perirenal lymph node"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35764904"
+- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2Sh"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [renal lymph node](http://purl.obolibrary.org/obo/UBERON_0003425) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "pararenal lymph node"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28346247"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [renal lymph node](http://purl.obolibrary.org/obo/UBERON_0003425) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "para-renal lymph node"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22740822"
+- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NAc shell and OT D2-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### renal medulla `http://purl.obolibrary.org/obo/UBERON_0000362`
+- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus accumbens shell and olfactory tubercle D2-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-#### Added
-- [renal medulla](http://purl.obolibrary.org/obo/UBERON_0000362) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [renal medulla](http://purl.obolibrary.org/obo/UBERON_0000362) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_R.glb"
-- [renal medulla](http://purl.obolibrary.org/obo/UBERON_0000362) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_L.glb"
+### obsolete animal cell `http://purl.obolibrary.org/obo/CL_0000548`
+#### Removed
+- [obsolete animal cell](http://purl.obolibrary.org/obo/CL_0000548) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Animal_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [renal medulla](http://purl.obolibrary.org/obo/UBERON_0000362) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb"
+#### Added
+- [obsolete animal cell](http://purl.obolibrary.org/obo/CL_0000548) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://www.swissbiopics.org/api/image/Animal_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### renal papilla `http://purl.obolibrary.org/obo/UBERON_0001228`
+### obsolete choroid plexus cell `http://purl.obolibrary.org/obo/CL_4023073`
+#### Removed
+- [obsolete choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-#### Added
-- [renal papilla](http://purl.obolibrary.org/obo/UBERON_0001228) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_L.glb"
+- [obsolete choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [renal papilla](http://purl.obolibrary.org/obo/UBERON_0001228) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Ureter_L.glb"
-- [renal papilla](http://purl.obolibrary.org/obo/UBERON_0001228) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Ureter_R.glb"
-- [renal papilla](http://purl.obolibrary.org/obo/UBERON_0001228) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_R.glb"
+### occurs in `http://purl.obolibrary.org/obo/BFO_0000066`
+#### Removed
+- [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "gene_ontology"
-### renal vein `http://purl.obolibrary.org/obo/UBERON_0001140`
-#### Added
-- [renal vein](http://purl.obolibrary.org/obo/UBERON_0001140) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+### oligodendrocyte precursor cell `http://purl.obolibrary.org/obo/CL_0002453`
+#### Removed
+- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O2A/OPC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [renal vein](http://purl.obolibrary.org/obo/UBERON_0001140) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11756508"
+- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O-2A/OPC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### requires discussion `http://purl.obolibrary.org/obo/IAO_0000428`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24133281"
#### Added
-- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en
+- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O-2A/OPC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24133281"
-- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [label](http://www.w3.org/2000/01/rdf-schema#label) "requires discussion"@en
+- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O2A/OPC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "requires discussion"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11756508"
-- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
-- Individual: [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428)
+### onychocyte `http://purl.obolibrary.org/obo/CL_4033056`
+#### Added
+- [onychocyte](http://purl.obolibrary.org/obo/CL_4033056) [date](http://purl.org/dc/terms/date) "2023-10-03T12:49:46Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-### respiratory system `http://purl.obolibrary.org/obo/UBERON_0001004`
+- [onychocyte](http://purl.obolibrary.org/obo/CL_4033056) [label](http://www.w3.org/2000/01/rdf-schema#label) "onychocyte"
-#### Added
-- [respiratory system](http://purl.obolibrary.org/obo/UBERON_0001004) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [onychocyte](http://purl.obolibrary.org/obo/CL_4033056) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A differentiated flat keratinocyte that is part of a nail plate. An onychocyte is firmly adherent and does not desquamate."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24079581"
-- [respiratory system](http://purl.obolibrary.org/obo/UBERON_0001004) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+- [onychocyte](http://purl.obolibrary.org/obo/CL_4033056) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-- [respiratory system](http://purl.obolibrary.org/obo/UBERON_0001004) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+- Class: [onychocyte](http://purl.obolibrary.org/obo/CL_4033056)
-- [respiratory system](http://purl.obolibrary.org/obo/UBERON_0001004) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+- [onychocyte](http://purl.obolibrary.org/obo/CL_4033056) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nail plate](http://purl.obolibrary.org/obo/UBERON_0008198)
-- [respiratory system](http://purl.obolibrary.org/obo/UBERON_0001004) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb"
+- [onychocyte](http://purl.obolibrary.org/obo/CL_4033056) SubClassOf [keratinocyte](http://purl.obolibrary.org/obo/CL_0000312)
-### retina horizontal cell `http://purl.obolibrary.org/obo/CL_0000745`
+### organ `http://purl.obolibrary.org/obo/UBERON_0000062`
#### Removed
-- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [organ](http://purl.obolibrary.org/obo/UBERON_0000062) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-#### Added
-- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### organism `http://purl.obolibrary.org/obo/CARO_0001010`
+#### Removed
+- [organism](http://purl.obolibrary.org/obo/CARO_0001010) [label](http://www.w3.org/2000/01/rdf-schema#label) "organism"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [organism](http://purl.obolibrary.org/obo/CARO_0001010) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Melissa Haendel"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [organism](http://purl.obolibrary.org/obo/CARO_0001010) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "organism or virus or viroid"
+- [organism](http://purl.obolibrary.org/obo/CARO_0001010) [IAO_creation_date](http://purl.obolibrary.org/obo/IAO_creation_date) "9/18/11"
-### retinal astrocyte `http://purl.obolibrary.org/obo/CL_4033015`
-#### Removed
-- [retinal astrocyte](http://purl.obolibrary.org/obo/CL_4033015) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "retinal astroglia"
- - [synonym_type_property](http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty) [plural term](http://purl.obolibrary.org/obo/uberon/core#PLURAL)
+- [organism](http://purl.obolibrary.org/obo/CARO_0001010) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33796062"
+- Class: [organism](http://purl.obolibrary.org/obo/CARO_0001010)
-#### Added
-- [retinal astrocyte](http://purl.obolibrary.org/obo/CL_4033015) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "retinal astroglia"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33796062"
+- [organism](http://purl.obolibrary.org/obo/CARO_0001010) SubClassOf [material entity](http://purl.obolibrary.org/obo/BFO_0000040)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-### retinal bipolar neuron `http://purl.obolibrary.org/obo/CL_0000748`
+### organism subdivision `http://purl.obolibrary.org/obo/CARO_0000032`
#### Removed
-- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BPs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+- [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument."@en
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GSE137537"
+- [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Old definition: Anatomical structure which is a primary subdivision of whole organism. The mereological sum of these is the whole organism."
-- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) [label](http://www.w3.org/2000/01/rdf-schema#label) "organism subdivision"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+- [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000032"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [core](http://purl.obolibrary.org/obo/caro#core)
-#### Added
-- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- Class: [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [organism subdivision](http://purl.obolibrary.org/obo/CARO_0000032) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BPs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+### organism substance `http://purl.obolibrary.org/obo/CARO_0000004`
+#### Removed
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Examples include feces, urine, blood, blood plasma, lymph, hemolymph, cerbro-spinal fluid. This class does not encompass anatomical entities with inherent 3D structure such as dentine and arthropod cuticle."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GSE137537"
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body and that does not have inherent 3D shape generated by coordinated expression of the organism's own genome."
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) [label](http://www.w3.org/2000/01/rdf-schema#label) "organism substance"
-### retinal ganglion cell `http://purl.obolibrary.org/obo/CL_0000740`
-#### Removed
-- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0000004"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note - CARO explicitly declares organisms substances to be part of (some) organism."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "portion of organism substance"
-#### Added
-- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- Class: [organism substance](http://purl.obolibrary.org/obo/CARO_0000004)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [organism substance](http://purl.obolibrary.org/obo/CARO_0000004) SubClassOf [gross anatomical part](http://purl.obolibrary.org/obo/CARO_0001008)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### retinal melanocyte `http://purl.obolibrary.org/obo/CL_0002485`
+### ossification involved in bone remodeling `http://purl.obolibrary.org/obo/GO_0043932`
#### Removed
-- [retinal melanocyte](http://purl.obolibrary.org/obo/CL_0002485) SubClassOf [melanocyte](http://purl.obolibrary.org/obo/CL_0000148)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [ossification involved in bone remodeling](http://purl.obolibrary.org/obo/GO_0043932) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ossification involved in bone remodelling"
#### Added
-- [retinal melanocyte](http://purl.obolibrary.org/obo/CL_0002485) SubClassOf [melanocyte](http://purl.obolibrary.org/obo/CL_0000148)
+- [ossification involved in bone remodeling](http://purl.obolibrary.org/obo/GO_0043932) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ossification involved in bone remodelling"
-### retinal pigment epithelial cell `http://purl.obolibrary.org/obo/CL_0002586`
+### oxytocin receptor sst GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023122`
#### Removed
-- [retinal pigment epithelial cell](http://purl.obolibrary.org/obo/CL_0002586) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [oxytocin receptor sst GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023122) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "OxtrINs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25303526"
#### Added
-- [retinal pigment epithelial cell](http://purl.obolibrary.org/obo/CL_0002586) SubClassOf [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066)
+- [oxytocin receptor sst GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023122) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "OxtrINs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25303526"
+
+### peg cell `http://purl.obolibrary.org/obo/CL_4033014`
+#### Removed
+- [peg cell](http://purl.obolibrary.org/obo/CL_4033014) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "FTESC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### right cardiac atrium `http://purl.obolibrary.org/obo/UBERON_0002078`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22911892"
#### Added
-- [right cardiac atrium](http://purl.obolibrary.org/obo/UBERON_0002078) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
+- [peg cell](http://purl.obolibrary.org/obo/CL_4033014) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "FTESC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [right cardiac atrium](http://purl.obolibrary.org/obo/UBERON_0002078) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22911892"
+- [peg cell](http://purl.obolibrary.org/obo/CL_4033014) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### right cerebral hemisphere `http://purl.obolibrary.org/obo/UBERON_0002813`
+- [peg cell](http://purl.obolibrary.org/obo/CL_4033014) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-#### Added
-- [right cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002813) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
-- [right cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002813) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+### pharyngeal gland morphogenesis `http://purl.obolibrary.org/obo/GO_1905905`
+#### Removed
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "pharynx gland morphogenesis"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "glandulae pharyngeae morphogenesis"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-### right eye `http://purl.obolibrary.org/obo/UBERON_0004549`
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The developmental process by which a pharyngeal gland is generated and organized."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-#### Added
-- [right eye](http://purl.obolibrary.org/obo/UBERON_0004549) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-eye-r.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000083"
-- [right eye](http://purl.obolibrary.org/obo/UBERON_0004549) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_R.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21868609"
-- [right eye](http://purl.obolibrary.org/obo/UBERON_0004549) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb"
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905905"
-- [right eye](http://purl.obolibrary.org/obo/UBERON_0004549) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-eye-r.glb"
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rz"
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [label](http://www.w3.org/2000/01/rdf-schema#label) "pharyngeal gland morphogenesis"
-### right kidney `http://purl.obolibrary.org/obo/UBERON_0004539`
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-#### Added
-- [right kidney](http://purl.obolibrary.org/obo/UBERON_0004539) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Kidney_Right.glb"
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-02-03T14:39:10Z"
-- [right kidney](http://purl.obolibrary.org/obo/UBERON_0004539) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Kidney_R.glb"
+- Class: [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905)
-- [right kidney](http://purl.obolibrary.org/obo/UBERON_0004539) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Kidney_R.glb"
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) EquivalentTo [anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0009653) and ([results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [pharyngeal gland](http://purl.obolibrary.org/obo/UBERON_0003295))
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) SubClassOf [gland morphogenesis](http://purl.obolibrary.org/obo/GO_0022612)
-### right lobe of liver `http://purl.obolibrary.org/obo/UBERON_0001114`
+- [pharyngeal gland morphogenesis](http://purl.obolibrary.org/obo/GO_1905905) SubClassOf [results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [pharyngeal gland](http://purl.obolibrary.org/obo/UBERON_0003295)
-#### Added
-- [right lobe of liver](http://purl.obolibrary.org/obo/UBERON_0001114) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb"
-- [right lobe of liver](http://purl.obolibrary.org/obo/UBERON_0001114) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb"
+### pharyngeal muscle development `http://purl.obolibrary.org/obo/GO_0043282`
+#### Removed
+- [pharyngeal muscle development](http://purl.obolibrary.org/obo/GO_0043282) [label](http://www.w3.org/2000/01/rdf-schema#label) "pharyngeal muscle development"
-### right lung `http://purl.obolibrary.org/obo/UBERON_0002167`
+- [pharyngeal muscle development](http://purl.obolibrary.org/obo/GO_0043282) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pharynx development](http://purl.obolibrary.org/obo/GO_0060465)
#### Added
-- [right lung](http://purl.obolibrary.org/obo/UBERON_0002167) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
+- [pharyngeal muscle development](http://purl.obolibrary.org/obo/GO_0043282) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/18285"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [right lung](http://purl.obolibrary.org/obo/UBERON_0002167) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+- [pharyngeal muscle development](http://purl.obolibrary.org/obo/GO_0043282) [label](http://www.w3.org/2000/01/rdf-schema#label) "chordate pharyngeal muscle development"
-- [right lung](http://purl.obolibrary.org/obo/UBERON_0002167) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [pharyngeal muscle development](http://purl.obolibrary.org/obo/GO_0043282) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [chordate pharynx development](http://purl.obolibrary.org/obo/GO_0160093)
-- [right lung](http://purl.obolibrary.org/obo/UBERON_0002167) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+### pharynx morphogenesis `http://purl.obolibrary.org/obo/GO_0110040`
+#### Removed
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-### right nipple `http://purl.obolibrary.org/obo/UBERON_0013773`
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) [label](http://www.w3.org/2000/01/rdf-schema#label) "pharynx morphogenesis"
-#### Added
-- [right nipple](http://purl.obolibrary.org/obo/UBERON_0013773) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.3/3d-vh-f-mammary-gland-r.glb"
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which the anatomical structures of the pharynx are generated and organized."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rz"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20805556"
-### right pulmonary artery `http://purl.obolibrary.org/obo/UBERON_0001651`
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-07-24T20:51:28Z"
-#### Added
-- [right pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0001651) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0110040"
-- [right pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0001651) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
+- Class: [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040)
-### right putamen `http://purl.obolibrary.org/obo/UBERON_0008885`
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) EquivalentTo [anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0009653) and ([results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [pharynx](http://purl.obolibrary.org/obo/UBERON_0006562))
-#### Added
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) SubClassOf [anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0009653)
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040) SubClassOf [results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [pharynx](http://purl.obolibrary.org/obo/UBERON_0006562)
-### right renal artery `http://purl.obolibrary.org/obo/UBERON_0001185`
+
+### photoreceptor cell `http://purl.obolibrary.org/obo/CL_0000210`
+#### Removed
+- [photoreceptor cell](http://purl.obolibrary.org/obo/CL_0000210) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
#### Added
-- [right renal artery](http://purl.obolibrary.org/obo/UBERON_0001185) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [photoreceptor cell](http://purl.obolibrary.org/obo/CL_0000210) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### physical object quality `http://purl.obolibrary.org/obo/PATO_0001241`
+#### Removed
+- [physical object quality](http://purl.obolibrary.org/obo/PATO_0001241) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "multiply inhering quality of a physical entity "
-- [right renal artery](http://purl.obolibrary.org/obo/UBERON_0001185) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-### right renal vein `http://purl.obolibrary.org/obo/UBERON_0001141`
+### placental amniotic mesenchymal stromal cell `http://purl.obolibrary.org/obo/CL_2000061`
#### Added
-- [right renal vein](http://purl.obolibrary.org/obo/UBERON_0001141) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [placental amniotic mesenchymal stromal cell](http://purl.obolibrary.org/obo/CL_2000061) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [right renal vein](http://purl.obolibrary.org/obo/UBERON_0001141) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [placental amniotic mesenchymal stromal cell](http://purl.obolibrary.org/obo/CL_2000061) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### right thymus lobe `http://purl.obolibrary.org/obo/UBERON_0005469`
+### placental villus capillary endothelial cell `http://purl.obolibrary.org/obo/CL_2000062`
+#### Removed
+- [placental villus capillary endothelial cell](http://purl.obolibrary.org/obo/CL_2000062) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-#### Added
-- [right thymus lobe](http://purl.obolibrary.org/obo/UBERON_0005469) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Thymus.glb"
+- [placental villus capillary endothelial cell](http://purl.obolibrary.org/obo/CL_2000062) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [right thymus lobe](http://purl.obolibrary.org/obo/UBERON_0005469) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Thymus.glb"
-### right ureter `http://purl.obolibrary.org/obo/UBERON_0001222`
+### plus `http://purl.obolibrary.org/obo/caro#plus`
+#### Removed
+- AnnotationProperty: [plus](http://purl.obolibrary.org/obo/caro#plus)
-#### Added
-- [right ureter](http://purl.obolibrary.org/obo/UBERON_0001222) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Ureter_R.glb"
+- [plus](http://purl.obolibrary.org/obo/caro#plus) SubPropertyOf: [subset_property](http://www.geneontology.org/formats/oboInOwl#SubsetProperty)
-- [right ureter](http://purl.obolibrary.org/obo/UBERON_0001222) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Ureter_R.glb"
-### right uterine tube `http://purl.obolibrary.org/obo/UBERON_0001302`
+### positive regulation of acetylcholine biosynthetic process `http://purl.obolibrary.org/obo/GO_1905923`
+#### Removed
+- [positive regulation of acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_1905923) SubClassOf [positive regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031328)
#### Added
-- [right uterine tube](http://purl.obolibrary.org/obo/UBERON_0001302) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Fallopian_Tube_R.glb"
+- [positive regulation of acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_1905923) SubClassOf [positive regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009891)
-### rod bipolar cell `http://purl.obolibrary.org/obo/CL_0000751`
-
-#### Added
-- [rod bipolar cell](http://purl.obolibrary.org/obo/CL_0000751) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+### positive regulation of acetylcholine metabolic process `http://purl.obolibrary.org/obo/GO_0060409`
+#### Removed
+- [positive regulation of acetylcholine metabolic process](http://purl.obolibrary.org/obo/GO_0060409) SubClassOf [positive regulation of cellular metabolic process](http://purl.obolibrary.org/obo/GO_0031325)
-### root `http://purl.obolibrary.org/obo/NCBITaxon_1`
-#### Added
-- [root](http://purl.obolibrary.org/obo/NCBITaxon_1) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30365038"
+### positive regulation of basophil degranulation `http://purl.obolibrary.org/obo/GO_1903583`
+#### Removed
+- [positive regulation of basophil degranulation](http://purl.obolibrary.org/obo/GO_1903583) SubClassOf [positive regulation of leukocyte activation](http://purl.obolibrary.org/obo/GO_0002696)
-- [root](http://purl.obolibrary.org/obo/NCBITaxon_1) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32761142"
-### rosehip neuron `http://purl.obolibrary.org/obo/CL_0008032`
+### positive regulation of blood vessel remodeling `http://purl.obolibrary.org/obo/GO_2000504`
#### Added
-- [rosehip neuron](http://purl.obolibrary.org/obo/CL_0008032) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [positive regulation of blood vessel remodeling](http://purl.obolibrary.org/obo/GO_2000504) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of blood vessel remodelling"
-### salivary gland cell `http://purl.obolibrary.org/obo/CL_0009005`
-#### Removed
-- [salivary gland cell](http://purl.obolibrary.org/obo/CL_0009005) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### positive regulation of bone remodeling `http://purl.obolibrary.org/obo/GO_0046852`
#### Added
-- [salivary gland cell](http://purl.obolibrary.org/obo/CL_0009005) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [positive regulation of bone remodeling](http://purl.obolibrary.org/obo/GO_0046852) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of bone remodelling"
-### saphenous vein smooth muscle tissue `http://purl.obolibrary.org/obo/UBERON_8480068`
+### positive regulation of cell population proliferation `http://purl.obolibrary.org/obo/GO_0008284`
#### Added
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-0819-0473](https://orcid.org/0000-0002-0819-0473)
+- [positive regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0008284) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)))
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A portion of smooth muscle tissue that is part of a saphenous vein."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0002-0819-0473"
+- [positive regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0008284) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8480068"
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) [date](http://purl.org/dc/terms/date) "2023-08-31T11:41:09Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) [label](http://www.w3.org/2000/01/rdf-schema#label) "saphenous vein smooth muscle tissue"
+### positive regulation of cytotoxic T cell degranulation `http://purl.obolibrary.org/obo/GO_0043319`
+#### Removed
+- [positive regulation of cytotoxic T cell degranulation](http://purl.obolibrary.org/obo/GO_0043319) SubClassOf [positive regulation of T cell activation](http://purl.obolibrary.org/obo/GO_0050870)
-- Class: [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068)
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) EquivalentTo [smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_0001135) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [saphenous vein](http://purl.obolibrary.org/obo/UBERON_0007318))
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [saphenous vein](http://purl.obolibrary.org/obo/UBERON_0007318)
+### positive regulation of eosinophil degranulation `http://purl.obolibrary.org/obo/GO_0043311`
+#### Removed
+- [positive regulation of eosinophil degranulation](http://purl.obolibrary.org/obo/GO_0043311) SubClassOf [positive regulation of eosinophil activation](http://purl.obolibrary.org/obo/GO_1902568)
-- [saphenous vein smooth muscle tissue](http://purl.obolibrary.org/obo/UBERON_8480068) SubClassOf [venous system smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004696)
-### scleral cell `http://purl.obolibrary.org/obo/CL_0000347`
-#### Removed
-- [scleral cell](http://purl.obolibrary.org/obo/CL_0000347) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+### positive regulation of histamine secretion by mast cell `http://purl.obolibrary.org/obo/GO_1903595`
+#### Added
+- [positive regulation of histamine secretion by mast cell](http://purl.obolibrary.org/obo/GO_1903595) SubClassOf [positive regulation of multicellular organismal process](http://purl.obolibrary.org/obo/GO_0051240)
-### scolopale cell `http://purl.obolibrary.org/obo/CL_0000382`
+### positive regulation of mast cell degranulation `http://purl.obolibrary.org/obo/GO_0043306`
#### Removed
-- [scolopale cell](http://purl.obolibrary.org/obo/CL_0000382) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [positive regulation of mast cell degranulation](http://purl.obolibrary.org/obo/GO_0043306) SubClassOf [positive regulation of mast cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0033008)
-### scolopidial ligament cell `http://purl.obolibrary.org/obo/CL_0000407`
+### positive regulation of natural killer cell degranulation `http://purl.obolibrary.org/obo/GO_0043323`
#### Removed
-- [scolopidial ligament cell](http://purl.obolibrary.org/obo/CL_0000407) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [positive regulation of natural killer cell degranulation](http://purl.obolibrary.org/obo/GO_0043323) SubClassOf [positive regulation of natural killer cell activation](http://purl.obolibrary.org/obo/GO_0032816)
-### sebaceous gland cell `http://purl.obolibrary.org/obo/CL_2000021`
+### positive regulation of neutrophil degranulation `http://purl.obolibrary.org/obo/GO_0043315`
#### Removed
-- [sebaceous gland cell](http://purl.obolibrary.org/obo/CL_2000021) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [sebaceous gland](http://purl.obolibrary.org/obo/UBERON_0001821))
-
-- [sebaceous gland cell](http://purl.obolibrary.org/obo/CL_2000021) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-#### Added
-- [sebaceous gland cell](http://purl.obolibrary.org/obo/CL_2000021) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [sebaceous gland](http://purl.obolibrary.org/obo/UBERON_0001821))
+- [positive regulation of neutrophil degranulation](http://purl.obolibrary.org/obo/GO_0043315) SubClassOf [positive regulation of neutrophil activation](http://purl.obolibrary.org/obo/GO_1902565)
-- [sebaceous gland cell](http://purl.obolibrary.org/obo/CL_2000021) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### secondary crest myofibroblast `http://purl.obolibrary.org/obo/CL_4033016`
+### positive regulation of pharynx morphogenesis `http://purl.obolibrary.org/obo/GO_0110043`
#### Removed
-- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCMFs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0110043"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of pharynx morphogenesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25448080"
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-07-24T21:09:48Z"
-#### Added
-- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCMFs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25448080"
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of pharynx morphogenesis."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rz"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20805556"
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
-### secondary neuron (sensu Teleostei) `http://purl.obolibrary.org/obo/CL_0000535`
+- Class: [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043)
-#### Added
-- [secondary neuron (sensu Teleostei)](http://purl.obolibrary.org/obo/CL_0000535) SubClassOf [eukaryotic cell](http://purl.obolibrary.org/obo/CL_0000255)
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040))
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) SubClassOf [positive regulation of developmental process](http://purl.obolibrary.org/obo/GO_0051094)
-### secondary spermatocyte `http://purl.obolibrary.org/obo/CL_0000657`
-#### Removed
-- [secondary spermatocyte](http://purl.obolibrary.org/obo/CL_0000657) SubClassOf [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040)
-#### Added
-- [secondary spermatocyte](http://purl.obolibrary.org/obo/CL_0000657) SubClassOf [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017)
+- [positive regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110043) SubClassOf [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041)
-### secretory cell `http://purl.obolibrary.org/obo/CL_0000151`
-#### Removed
-- [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [secretion by cell](http://purl.obolibrary.org/obo/GO_0032940))
-- [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### positive regulation of pulmonary blood vessel remodeling `http://purl.obolibrary.org/obo/GO_1905111`
#### Added
-- [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [secretion by cell](http://purl.obolibrary.org/obo/GO_0032940))
+- [positive regulation of pulmonary blood vessel remodeling](http://purl.obolibrary.org/obo/GO_1905111) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of pulmonary blood vessel remodelling"
-- [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-
-### segmental bronchus `http://purl.obolibrary.org/obo/UBERON_0002184`
+### positive regulation of tissue remodeling `http://purl.obolibrary.org/obo/GO_0034105`
#### Added
-- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [positive regulation of tissue remodeling](http://purl.obolibrary.org/obo/GO_0034105) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of tissue remodelling"
-- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb"
-- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb"
+### positively regulates `http://purl.obolibrary.org/obo/RO_0002213`
+#### Removed
+- [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "gene_ontology"
-- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
-### seminal vesicle `http://purl.obolibrary.org/obo/UBERON_0000998`
+### post-embryonic animal organ development `http://purl.obolibrary.org/obo/GO_0048569`
+#### Removed
+- [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "post-embryonic animal organogenesis"
-#### Added
-- [seminal vesicle](http://purl.obolibrary.org/obo/UBERON_0000998) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb"
+- [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569) [label](http://www.w3.org/2000/01/rdf-schema#label) "post-embryonic animal organ development"
+- [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-### sensory epithelial cell `http://purl.obolibrary.org/obo/CL_0000098`
-#### Removed
-- [sensory epithelial cell](http://purl.obolibrary.org/obo/CL_0000098) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0048569"
+- [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
+- Class: [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569)
-### sensory receptor cell `http://purl.obolibrary.org/obo/CL_0000197`
-#### Removed
-- [sensory receptor cell](http://purl.obolibrary.org/obo/CL_0000197) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569) SubClassOf [animal organ development](http://purl.obolibrary.org/obo/GO_0048513)
-#### Added
-- [sensory receptor cell](http://purl.obolibrary.org/obo/CL_0000197) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### sheath cell (sensu Nematoda) `http://purl.obolibrary.org/obo/CL_0000367`
+### post-embryonic animal organ morphogenesis `http://purl.obolibrary.org/obo/GO_0048563`
#### Removed
-- [sheath cell (sensu Nematoda)](http://purl.obolibrary.org/obo/CL_0000367) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) [label](http://www.w3.org/2000/01/rdf-schema#label) "post-embryonic animal organ morphogenesis"
-### sigmoid colon `http://purl.obolibrary.org/obo/UBERON_0001159`
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0048563"
-#### Added
-- [sigmoid colon](http://purl.obolibrary.org/obo/UBERON_0001159) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
+- Class: [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563)
-- [sigmoid colon](http://purl.obolibrary.org/obo/UBERON_0001159) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569)
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) SubClassOf [animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0009887)
-### single fate stem cell `http://purl.obolibrary.org/obo/CL_0000035`
-#### Removed
-- [single fate stem cell](http://purl.obolibrary.org/obo/CL_0000035) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [unipotent](http://purl.obolibrary.org/obo/PATO_0001400)) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [stem cell division](http://purl.obolibrary.org/obo/GO_0017145))
+- [post-embryonic animal organ morphogenesis](http://purl.obolibrary.org/obo/GO_0048563) SubClassOf [post-embryonic animal morphogenesis](http://purl.obolibrary.org/obo/GO_0009886)
-#### Added
-- [single fate stem cell](http://purl.obolibrary.org/obo/CL_0000035) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [unipotent](http://purl.obolibrary.org/obo/PATO_0001400)) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [stem cell division](http://purl.obolibrary.org/obo/GO_0017145))
-### single nucleate cell `http://purl.obolibrary.org/obo/CL_0000226`
+### post-embryonic hemopoiesis `http://purl.obolibrary.org/obo/GO_0035166`
#### Removed
-- [single nucleate cell](http://purl.obolibrary.org/obo/CL_0000226) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mononucleate](http://purl.obolibrary.org/obo/PATO_0001407))
+- [post-embryonic hemopoiesis](http://purl.obolibrary.org/obo/GO_0035166) SubClassOf [post-embryonic animal organ development](http://purl.obolibrary.org/obo/GO_0048569)
-#### Added
-- [single nucleate cell](http://purl.obolibrary.org/obo/CL_0000226) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [mononucleate](http://purl.obolibrary.org/obo/PATO_0001407))
-### skeletal muscle myoblast `http://purl.obolibrary.org/obo/CL_0000515`
+### professional antigen presenting cell `http://purl.obolibrary.org/obo/CL_0000145`
#### Removed
-- [skeletal muscle myoblast](http://purl.obolibrary.org/obo/CL_0000515) SubClassOf [myoblast](http://purl.obolibrary.org/obo/CL_0000056)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [professional antigen presenting cell](http://purl.obolibrary.org/obo/CL_0000145) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [skeletal muscle myoblast](http://purl.obolibrary.org/obo/CL_0000515) SubClassOf [myoblast](http://purl.obolibrary.org/obo/CL_0000056)
+- [professional antigen presenting cell](http://purl.obolibrary.org/obo/CL_0000145) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### skeletogenic cell `http://purl.obolibrary.org/obo/CL_0007001`
+### prostate gland microvascular endothelial cell `http://purl.obolibrary.org/obo/CL_2000059`
#### Removed
-- [skeletogenic cell](http://purl.obolibrary.org/obo/CL_0007001) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
-
-#### Added
-- [skeletogenic cell](http://purl.obolibrary.org/obo/CL_0007001) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-
+- [prostate gland microvascular endothelial cell](http://purl.obolibrary.org/obo/CL_2000059) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### skin of body `http://purl.obolibrary.org/obo/UBERON_0002097`
+- [prostate gland microvascular endothelial cell](http://purl.obolibrary.org/obo/CL_2000059) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-#### Added
-- [skin of body](http://purl.obolibrary.org/obo/UBERON_0002097) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Skin.glb"
-- [skin of body](http://purl.obolibrary.org/obo/UBERON_0002097) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.3/3d-vh-f-skin.glb"
-- [skin of body](http://purl.obolibrary.org/obo/UBERON_0002097) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Skin.glb"
+### prostate neuroendocrine cell `http://purl.obolibrary.org/obo/CL_0017002`
-- [skin of body](http://purl.obolibrary.org/obo/UBERON_0002097) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Skin.glb"
+#### Added
+- [prostate neuroendocrine cell](http://purl.obolibrary.org/obo/CL_0017002) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [skin of body](http://purl.obolibrary.org/obo/UBERON_0002097) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_M_Skin.glb"
+- [prostate neuroendocrine cell](http://purl.obolibrary.org/obo/CL_0017002) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### skin of gonad `http://purl.obolibrary.org/obo/UBERON_8480074`
+### protein kinase activity `http://purl.obolibrary.org/obo/GO_0004672`
#### Added
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-0819-0473](https://orcid.org/0000-0002-0819-0473)
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9732753"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "JAK1-activated RAF1 phosphorylates MAPKs"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8480074"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9833820"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "PKR dimer autophosphorylates"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) [date](http://purl.org/dc/terms/date) "2023-08-29T10:24:24Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836404"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates MAPT"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) [label](http://www.w3.org/2000/01/rdf-schema#label) "skin of gonad"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836184"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates CDK1"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A zone of skin part of some gonad."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0002-0819-0473"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836159"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates DHX9"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836322"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates MKK6"
-- Class: [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074)
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836435"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates SNCA"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) EquivalentTo [zone of skin](http://purl.obolibrary.org/obo/UBERON_0000014) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [gonad](http://purl.obolibrary.org/obo/UBERON_0000991))
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836362"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates TP53 tetramer"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [gonad](http://purl.obolibrary.org/obo/UBERON_0000991)
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836449"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates HIV tat"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) SubClassOf [reproductive structure](http://purl.obolibrary.org/obo/UBERON_0005156)
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836383"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates ILF3:ILF2"
-- [skin of gonad](http://purl.obolibrary.org/obo/UBERON_8480074) SubClassOf [zone of skin](http://purl.obolibrary.org/obo/UBERON_0000014)
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836617"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates SPHK1"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9835885"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates eIF2-alpha"
-### small intestine `http://purl.obolibrary.org/obo/UBERON_0002108`
-
-#### Added
-- [small intestine](http://purl.obolibrary.org/obo/UBERON_0002108) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Small_Intestine.glb"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836515"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates PTPN2"
-- [small intestine](http://purl.obolibrary.org/obo/UBERON_0002108) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Small_Intestine.glb"
+- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9836664"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-PKR dimer phosphorylates PPP2R5A"
-### smooth muscle myoblast `http://purl.obolibrary.org/obo/CL_0000514`
-#### Removed
-- [smooth muscle myoblast](http://purl.obolibrary.org/obo/CL_0000514) SubClassOf [myoblast](http://purl.obolibrary.org/obo/CL_0000056)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+### protein transporter activity `http://purl.obolibrary.org/obo/GO_0140318`
#### Added
-- [smooth muscle myoblast](http://purl.obolibrary.org/obo/CL_0000514) SubClassOf [myoblast](http://purl.obolibrary.org/obo/CL_0000056)
+- [protein transporter activity](http://purl.obolibrary.org/obo/GO_0140318) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2248891"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "M6PR transports activated ARSA to the lysosome"
-### somatic cell `http://purl.obolibrary.org/obo/CL_0002371`
+### protein tyrosine kinase activity `http://purl.obolibrary.org/obo/GO_0004713`
#### Removed
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [label](http://www.w3.org/2000/01/rdf-schema#label) "somatic cell"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9762209"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "BACH1 is phosphorylated at tyrosine 486"
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5357429"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "AXL autophosphorylates on Y772 and Y814"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721662544"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8964252"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC"
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8964242"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC"
#### Added
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [cell](http://purl.obolibrary.org/obo/CL_0000000)
-
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete somatic cell"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9732738"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "JAK1-mediated phosphorylation of RAF1"
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5357429"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "AXL autophosphorylates on Y779 and Y821"
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "OBSOLETE. A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9762209"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "BACH1 is phosphorylated at tyrosine 483"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721662544"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8964252"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC"
-- [somatic cell](http://purl.obolibrary.org/obo/CL_0002371) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "https://github.com/obophenotype/cell-ontology/issues/1150"
+- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8964242"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC"
-### somatic nurse-like cell `http://purl.obolibrary.org/obo/CL_4029003`
-#### Removed
-- [somatic nurse-like cell](http://purl.obolibrary.org/obo/CL_4029003) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### pulmonary artery endothelial cell `http://purl.obolibrary.org/obo/CL_1001568`
+#### Added
+- [pulmonary artery endothelial cell](http://purl.obolibrary.org/obo/CL_1001568) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [pulmonary artery endothelial cell](http://purl.obolibrary.org/obo/CL_1001568) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### somatic stem cell `http://purl.obolibrary.org/obo/CL_0000723`
-#### Removed
-- [somatic stem cell](http://purl.obolibrary.org/obo/CL_0000723) SubClassOf [stem cell](http://purl.obolibrary.org/obo/CL_0000034)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
-- [somatic stem cell](http://purl.obolibrary.org/obo/CL_0000723) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### pulmonary blood vessel remodeling `http://purl.obolibrary.org/obo/GO_0101010`
#### Added
-- [somatic stem cell](http://purl.obolibrary.org/obo/CL_0000723) SubClassOf [stem cell](http://purl.obolibrary.org/obo/CL_0000034)
+- [pulmonary blood vessel remodeling](http://purl.obolibrary.org/obo/GO_0101010) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "pulmonary blood vessel remodelling"
-### spermatid `http://purl.obolibrary.org/obo/CL_0000018`
+### pulmonary interstitial fibroblast `http://purl.obolibrary.org/obo/CL_0002241`
#### Removed
-- [spermatid](http://purl.obolibrary.org/obo/CL_0000018) SubClassOf [male germ cell](http://purl.obolibrary.org/obo/CL_0000015)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [pulmonary interstitial fibroblast](http://purl.obolibrary.org/obo/CL_0002241) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [spermatid](http://purl.obolibrary.org/obo/CL_0000018) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [pulmonary interstitial fibroblast](http://purl.obolibrary.org/obo/CL_0002241) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-#### Added
-- [spermatid](http://purl.obolibrary.org/obo/CL_0000018) SubClassOf [male germ cell](http://purl.obolibrary.org/obo/CL_0000015)
-### spermatocyte `http://purl.obolibrary.org/obo/CL_0000017`
+### quality `http://purl.obolibrary.org/obo/PATO_0000001`
#### Removed
-- [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [quality](http://purl.obolibrary.org/obo/PATO_0000001) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "trait"
-- [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017) SubClassOf [male germ cell](http://purl.obolibrary.org/obo/CL_0000015)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [quality](http://purl.obolibrary.org/obo/PATO_0000001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PATOC:GVG"
-#### Added
-- [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017) SubClassOf [male germ cell](http://purl.obolibrary.org/obo/CL_0000015)
-### spermatogonium `http://purl.obolibrary.org/obo/CL_0000020`
+### regulates `http://purl.obolibrary.org/obo/RO_0002211`
#### Removed
-- [spermatogonium](http://purl.obolibrary.org/obo/CL_0000020) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [regulates](http://purl.obolibrary.org/obo/RO_0002211) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "gene_ontology"
-### spider amacrine cell `http://purl.obolibrary.org/obo/CL_0004225`
+### regulation of acetylcholine biosynthetic process `http://purl.obolibrary.org/obo/GO_1905921`
#### Removed
-- [spider amacrine cell](http://purl.obolibrary.org/obo/CL_0004225) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
-
-#### Added
-- [spider amacrine cell](http://purl.obolibrary.org/obo/CL_0004225) SubClassOf [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251)
-
-
-### spinal cord `http://purl.obolibrary.org/obo/UBERON_0002240`
+- [regulation of acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_1905921) SubClassOf [regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031326)
#### Added
-- [spinal cord](http://purl.obolibrary.org/obo/UBERON_0002240) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb"
+- [regulation of acetylcholine biosynthetic process](http://purl.obolibrary.org/obo/GO_1905921) SubClassOf [regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009889)
-- [spinal cord](http://purl.obolibrary.org/obo/UBERON_0002240) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb"
+### regulation of acetylcholine metabolic process `http://purl.obolibrary.org/obo/GO_0060408`
+#### Removed
+- [regulation of acetylcholine metabolic process](http://purl.obolibrary.org/obo/GO_0060408) SubClassOf [regulation of cellular metabolic process](http://purl.obolibrary.org/obo/GO_0031323)
-### spleen `http://purl.obolibrary.org/obo/UBERON_0002106`
-#### Added
-- [spleen](http://purl.obolibrary.org/obo/UBERON_0002106) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spleen.glb"
-- [spleen](http://purl.obolibrary.org/obo/UBERON_0002106) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Spleen.glb"
+### regulation of basophil degranulation `http://purl.obolibrary.org/obo/GO_1903581`
+#### Removed
+- [regulation of basophil degranulation](http://purl.obolibrary.org/obo/GO_1903581) SubClassOf [regulation of leukocyte activation](http://purl.obolibrary.org/obo/GO_0002694)
-- [spleen](http://purl.obolibrary.org/obo/UBERON_0002106) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spleen.glb"
-### splenic artery `http://purl.obolibrary.org/obo/UBERON_0001194`
+### regulation of blood vessel remodeling `http://purl.obolibrary.org/obo/GO_0060312`
#### Added
-- [splenic artery](http://purl.obolibrary.org/obo/UBERON_0001194) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [regulation of blood vessel remodeling](http://purl.obolibrary.org/obo/GO_0060312) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of blood vessel remodelling"
-- [splenic artery](http://purl.obolibrary.org/obo/UBERON_0001194) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
-
-### splenic vein `http://purl.obolibrary.org/obo/UBERON_0003713`
+### regulation of bone remodeling `http://purl.obolibrary.org/obo/GO_0046850`
#### Added
-- [splenic vein](http://purl.obolibrary.org/obo/UBERON_0003713) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
-
-- [splenic vein](http://purl.obolibrary.org/obo/UBERON_0003713) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [regulation of bone remodeling](http://purl.obolibrary.org/obo/GO_0046850) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of bone remodelling"
-### starburst amacrine cell `http://purl.obolibrary.org/obo/CL_0004232`
+### regulation of cytotoxic T cell degranulation `http://purl.obolibrary.org/obo/GO_0043317`
#### Removed
-- [starburst amacrine cell](http://purl.obolibrary.org/obo/CL_0004232) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
+- [regulation of cytotoxic T cell degranulation](http://purl.obolibrary.org/obo/GO_0043317) SubClassOf [regulation of T cell activation](http://purl.obolibrary.org/obo/GO_0050863)
-- [starburst amacrine cell](http://purl.obolibrary.org/obo/CL_0004232) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561)
-
-#### Added
-- [starburst amacrine cell](http://purl.obolibrary.org/obo/CL_0004232) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2. This cell type releases the neurotransmitters gamma-aminobutyric acid (GABA) and acetylcholine."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9620701"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
-- [starburst amacrine cell](http://purl.obolibrary.org/obo/CL_0004232) SubClassOf [cholinergic neuron](http://purl.obolibrary.org/obo/CL_0000108)
+### regulation of eosinophil degranulation `http://purl.obolibrary.org/obo/GO_0043309`
+#### Removed
+- [regulation of eosinophil degranulation](http://purl.obolibrary.org/obo/GO_0043309) SubClassOf [regulation of eosinophil activation](http://purl.obolibrary.org/obo/GO_1902566)
-- [starburst amacrine cell](http://purl.obolibrary.org/obo/CL_0004232) SubClassOf [GABAergic amacrine cell](http://purl.obolibrary.org/obo/CL_4030027)
-### stem cell `http://purl.obolibrary.org/obo/CL_0000034`
+### regulation of mast cell degranulation `http://purl.obolibrary.org/obo/GO_0043304`
#### Removed
-- [stem cell](http://purl.obolibrary.org/obo/CL_0000034) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [stem cell division](http://purl.obolibrary.org/obo/GO_0017145))
+- [regulation of mast cell degranulation](http://purl.obolibrary.org/obo/GO_0043304) SubClassOf [regulation of mast cell activation involved in immune response](http://purl.obolibrary.org/obo/GO_0033006)
-- [stem cell](http://purl.obolibrary.org/obo/CL_0000034) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
-
-#### Added
-- [stem cell](http://purl.obolibrary.org/obo/CL_0000034) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [stem cell division](http://purl.obolibrary.org/obo/GO_0017145))
-### stratified epithelial cell `http://purl.obolibrary.org/obo/CL_0000079`
+### regulation of natural killer cell degranulation `http://purl.obolibrary.org/obo/GO_0043321`
#### Removed
-- [stratified epithelial cell](http://purl.obolibrary.org/obo/CL_0000079) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [regulation of natural killer cell degranulation](http://purl.obolibrary.org/obo/GO_0043321) SubClassOf [regulation of natural killer cell activation](http://purl.obolibrary.org/obo/GO_0032814)
-### structural cell `http://purl.obolibrary.org/obo/CL_0000293`
+### regulation of neurotransmitter levels `http://purl.obolibrary.org/obo/GO_0001505`
#### Removed
-- [structural cell](http://purl.obolibrary.org/obo/CL_0000293) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates levels of neurotransmitter."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
-#### Added
-- [structural cell](http://purl.obolibrary.org/obo/CL_0000293) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0001505"
+- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-### stuff accumulating cell `http://purl.obolibrary.org/obo/CL_0000325`
-#### Removed
-- [stuff accumulating cell](http://purl.obolibrary.org/obo/CL_0000325) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of neurotransmitter levels"
-#### Added
-- [stuff accumulating cell](http://purl.obolibrary.org/obo/CL_0000325) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- Class: [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505)
+- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eumetazoa](http://purl.obolibrary.org/obo/NCBITaxon_6072)
-### subarachnoid space `http://purl.obolibrary.org/obo/UBERON_0000315`
-#### Removed
-- [subarachnoid space](http://purl.obolibrary.org/obo/UBERON_0000315) SubClassOf [contains](http://purl.obolibrary.org/obo/RO_0001019) some [blood vessel](http://purl.obolibrary.org/obo/UBERON_0001981)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ISBN:0471888893"
+- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eumetazoa](http://purl.obolibrary.org/obo/NCBITaxon_6072)
-- [subarachnoid space](http://purl.obolibrary.org/obo/UBERON_0000315) SubClassOf [contains](http://purl.obolibrary.org/obo/RO_0001019) some [cerebrospinal fluid](http://purl.obolibrary.org/obo/UBERON_0001359)
-#### Added
-- [subarachnoid space](http://purl.obolibrary.org/obo/UBERON_0000315) SubClassOf [location of](http://purl.obolibrary.org/obo/RO_0001015) some [blood vessel](http://purl.obolibrary.org/obo/UBERON_0001981)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ISBN:0471888893"
-- [subarachnoid space](http://purl.obolibrary.org/obo/UBERON_0000315) SubClassOf [location of](http://purl.obolibrary.org/obo/RO_0001015) some [cerebrospinal fluid](http://purl.obolibrary.org/obo/UBERON_0001359)
+### regulation of neutrophil degranulation `http://purl.obolibrary.org/obo/GO_0043313`
+#### Removed
+- [regulation of neutrophil degranulation](http://purl.obolibrary.org/obo/GO_0043313) SubClassOf [regulation of neutrophil activation](http://purl.obolibrary.org/obo/GO_1902563)
-### submucosal gland acinus `http://purl.obolibrary.org/obo/UBERON_8600012`
-#### Added
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+### regulation of pharynx morphogenesis `http://purl.obolibrary.org/obo/GO_0110041`
+#### Removed
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rz"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20805556"
-### submucosal gland ciliated duct `http://purl.obolibrary.org/obo/UBERON_8600014`
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-07-24T21:00:20Z"
-#### Added
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of pharynx morphogenesis"
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) [date](http://purl.org/dc/terms/date) "2023-05-02T08:09:14Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0110041"
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) [label](http://www.w3.org/2000/01/rdf-schema#label) "submucosal gland ciliated duct"
+- Class: [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041)
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated tubular structure in a submucosal gland connecting the submucosal gland collecting duct with the surface epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30864819"
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040))
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17707699"
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110040)
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8600014"
+- [regulation of pharynx morphogenesis](http://purl.obolibrary.org/obo/GO_0110041) SubClassOf [regulation of anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0022603)
-- Class: [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014)
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) SubClassOf [duct](http://purl.obolibrary.org/obo/UBERON_0000058)
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [submucosal gland](http://purl.obolibrary.org/obo/UBERON_0011148)
+### regulation of pulmonary blood vessel remodeling `http://purl.obolibrary.org/obo/GO_1905109`
-- [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_0000067)
+#### Added
+- [regulation of pulmonary blood vessel remodeling](http://purl.obolibrary.org/obo/GO_1905109) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of pulmonary blood vessel remodelling"
-### substantia nigra `http://purl.obolibrary.org/obo/UBERON_0002038`
+### regulation of tissue remodeling `http://purl.obolibrary.org/obo/GO_0034103`
#### Added
-- [substantia nigra](http://purl.obolibrary.org/obo/UBERON_0002038) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb"
+- [regulation of tissue remodeling](http://purl.obolibrary.org/obo/GO_0034103) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of tissue remodelling"
-- [substantia nigra](http://purl.obolibrary.org/obo/UBERON_0002038) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb"
+### relational_slim `http://purl.obolibrary.org/obo/pato#relational_slim`
+#### Removed
+- AnnotationProperty: [relational_slim](http://purl.obolibrary.org/obo/pato#relational_slim)
-### superior mesenteric artery `http://purl.obolibrary.org/obo/UBERON_0001182`
-
-#### Added
-- [superior mesenteric artery](http://purl.obolibrary.org/obo/UBERON_0001182) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [relational_slim](http://purl.obolibrary.org/obo/pato#relational_slim) SubPropertyOf: [subset_property](http://www.geneontology.org/formats/oboInOwl#SubsetProperty)
-- [superior mesenteric artery](http://purl.obolibrary.org/obo/UBERON_0001182) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
-### supporting cell `http://purl.obolibrary.org/obo/CL_0000630`
-#### Removed
-- [supporting cell](http://purl.obolibrary.org/obo/CL_0000630) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+### respiratory suprabasal cell `http://purl.obolibrary.org/obo/CL_4033048`
#### Added
-- [supporting cell](http://purl.obolibrary.org/obo/CL_0000630) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### syncytial epithelial cell `http://purl.obolibrary.org/obo/CL_0000420`
+
+### retina horizontal cell `http://purl.obolibrary.org/obo/CL_0000745`
#### Removed
-- [syncytial epithelial cell](http://purl.obolibrary.org/obo/CL_0000420) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### systemic artery `http://purl.obolibrary.org/obo/UBERON_0004573`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
#### Added
-- [systemic artery](http://purl.obolibrary.org/obo/UBERON_0004573) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [systemic artery](http://purl.obolibrary.org/obo/UBERON_0004573) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### term imported `http://purl.obolibrary.org/obo/IAO_0000228`
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term imported"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use."@en
-- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [label](http://www.w3.org/2000/01/rdf-schema#label) "term imported"@en
+### retinal bipolar neuron `http://purl.obolibrary.org/obo/CL_0000748`
+#### Removed
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BPs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-- Individual: [term imported](http://purl.obolibrary.org/obo/IAO_0000228)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GSE137537"
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### term replaced by `http://purl.obolibrary.org/obo/IAO_0100001`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-#### Added
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person:Alan Ruttenberg"@en
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term replaced by"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Add as annotation triples in the granting ontology"@en
+#### Added
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [label](http://www.w3.org/2000/01/rdf-schema#label) "term replaced by"@en
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BPs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GSE137537"
-### term split `http://purl.obolibrary.org/obo/IAO_0000229`
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-#### Added
-- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term split"@en
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [label](http://www.w3.org/2000/01/rdf-schema#label) "term split"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created."@en
-- Individual: [term split](http://purl.obolibrary.org/obo/IAO_0000229)
+### retinal ganglion cell `http://purl.obolibrary.org/obo/CL_0000740`
+#### Removed
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-### term tracker item `http://purl.obolibrary.org/obo/IAO_0000233`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-#### Added
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [label](http://www.w3.org/2000/01/rdf-schema#label) "term tracker item"@en
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The 'tracker item' can associate a tracker with a specific ontology term."@en
+#### Added
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An IRI or similar locator for a request or discussion of an ontology term."@en
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term tracker item"@en
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/"@en
+### role `http://purl.obolibrary.org/obo/BFO_0000023`
+#### Removed
+- [role](http://purl.obolibrary.org/obo/BFO_0000023) EquivalentTo [CHEBI_50906](http://purl.obolibrary.org/obo/CHEBI_50906)
-### terms merged `http://purl.obolibrary.org/obo/IAO_0000227`
+- [role](http://purl.obolibrary.org/obo/BFO_0000023) SubClassOf [CHEBI_50906](http://purl.obolibrary.org/obo/CHEBI_50906)
#### Added
-- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [label](http://www.w3.org/2000/01/rdf-schema#label) "terms merged"@en
+- [role](http://purl.obolibrary.org/obo/BFO_0000023) SubClassOf [realizable entity](http://purl.obolibrary.org/obo/BFO_0000017)
-- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "An editor note should explain what were the merged terms and the reason for the merge."@en
-- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "terms merged"@en
+### saccular `http://purl.obolibrary.org/obo/PATO_0001987`
+#### Removed
+- [saccular](http://purl.obolibrary.org/obo/PATO_0001987) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "sacular"
+ - [IAO_scope](http://purl.obolibrary.org/obo/IAO_scope) "EXACT"
-- Individual: [terms merged](http://purl.obolibrary.org/obo/IAO_0000227)
-### thecogen cell `http://purl.obolibrary.org/obo/CL_0000380`
+### secondary crest myofibroblast `http://purl.obolibrary.org/obo/CL_4033016`
#### Removed
-- [thecogen cell](http://purl.obolibrary.org/obo/CL_0000380) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCMFs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25448080"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
+- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCMF"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33624948"
-### thymus `http://purl.obolibrary.org/obo/UBERON_0002370`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
#### Added
-- [thymus](http://purl.obolibrary.org/obo/UBERON_0002370) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Thymus.glb"
-
-- [thymus](http://purl.obolibrary.org/obo/UBERON_0002370) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Thymus.glb"
+- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCMFs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [thymus](http://purl.obolibrary.org/obo/UBERON_0002370) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Thymus.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25448080"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural form](http://purl.obolibrary.org/obo/OMO_0003004)
-### tip cell `http://purl.obolibrary.org/obo/CL_0000423`
-#### Removed
-- [tip cell](http://purl.obolibrary.org/obo/CL_0000423) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCMF"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33624948"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### to be replaced with external ontology term `http://purl.obolibrary.org/obo/IAO_0000423`
+### secretory cell `http://purl.obolibrary.org/obo/CL_0000151`
+#### Removed
+- [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-#### Added
-- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+- [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en
-- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Terms with this status should eventually replaced with a term from another ontology."@en
-- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "to be replaced with external ontology term"@en
+### serotonin-gated monoatomic cation-selective channel activity `http://purl.obolibrary.org/obo/GO_0022850`
+#### Removed
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) [label](http://www.w3.org/2000/01/rdf-schema#label) "serotonin-gated monoatomic cation-selective channel activity"
-- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [label](http://www.w3.org/2000/01/rdf-schema#label) "to be replaced with external ontology term"@en
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([regulated by](http://purl.obolibrary.org/obo/RO_0002334) some [serotonin binding](http://purl.obolibrary.org/obo/GO_0051378)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906))
-- Individual: [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423)
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) SubClassOf [regulated by](http://purl.obolibrary.org/obo/RO_0002334) some [serotonin binding](http://purl.obolibrary.org/obo/GO_0051378)
+#### Added
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) [label](http://www.w3.org/2000/01/rdf-schema#label) "serotonin-gated monoatomic cation channel activity"
-### tonsil `http://purl.obolibrary.org/obo/UBERON_0002372`
-#### Removed
-- [tonsil](http://purl.obolibrary.org/obo/UBERON_0002372) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "serotonin-gated monoatomic cation-selective channel activity"
-- [tonsil](http://purl.obolibrary.org/obo/UBERON_0002372) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) EquivalentTo [gated channel activity](http://purl.obolibrary.org/obo/GO_0022836) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_23906](http://purl.obolibrary.org/obo/CHEBI_23906)) and ([has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_350546](http://purl.obolibrary.org/obo/CHEBI_350546))
+- [serotonin-gated monoatomic cation-selective channel activity](http://purl.obolibrary.org/obo/GO_0022850) SubClassOf [has small molecule activator](http://purl.obolibrary.org/obo/RO_0012001) some [CHEBI_350546](http://purl.obolibrary.org/obo/CHEBI_350546)
-### tonsil capsule `http://purl.obolibrary.org/obo/UBERON_0005207`
-#### Removed
-- [tonsil capsule](http://purl.obolibrary.org/obo/UBERON_0005207) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+### serous secreting cell of bronchus submucosal gland `http://purl.obolibrary.org/obo/CL_4033005`
-- [tonsil capsule](http://purl.obolibrary.org/obo/UBERON_0005207) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+#### Added
+- [serous secreting cell of bronchus submucosal gland](http://purl.obolibrary.org/obo/CL_4033005) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [serous secreting cell of bronchus submucosal gland](http://purl.obolibrary.org/obo/CL_4033005) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### tonsil epithelium `http://purl.obolibrary.org/obo/UBERON_0013696`
+### small bistratified retinal ganglion cell `http://purl.obolibrary.org/obo/CL_4033053`
#### Removed
-- [tonsil epithelium](http://purl.obolibrary.org/obo/UBERON_0013696) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "sbRGC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [tonsil epithelium](http://purl.obolibrary.org/obo/UBERON_0013696) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409"
+- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SBS ganglion cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
-### tonsil germinal center `http://purl.obolibrary.org/obo/UBERON_0013688`
-#### Removed
-- [tonsil germinal center](http://purl.obolibrary.org/obo/UBERON_0013688) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+#### Added
+- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "sbRGC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409"
-- [tonsil germinal center](http://purl.obolibrary.org/obo/UBERON_0013688) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SBS ganglion cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### trachea `http://purl.obolibrary.org/obo/UBERON_0003126`
+### smooth muscle cell of the pulmonary artery `http://purl.obolibrary.org/obo/CL_0002591`
#### Added
-- [trachea](http://purl.obolibrary.org/obo/UBERON_0003126) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-trachea.glb"
+- [smooth muscle cell of the pulmonary artery](http://purl.obolibrary.org/obo/CL_0002591) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [trachea](http://purl.obolibrary.org/obo/UBERON_0003126) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
+- [smooth muscle cell of the pulmonary artery](http://purl.obolibrary.org/obo/CL_0002591) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [trachea](http://purl.obolibrary.org/obo/UBERON_0003126) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-trachea.glb"
+### spherical bushy cell `http://purl.obolibrary.org/obo/CL_4023163`
+#### Removed
+- [spherical bushy cell](http://purl.obolibrary.org/obo/CL_4023163) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "SBC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### trachea cartilage `http://purl.obolibrary.org/obo/UBERON_0003604`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31881018"
#### Added
-- [trachea cartilage](http://purl.obolibrary.org/obo/UBERON_0003604) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-trachea.glb"
+- [spherical bushy cell](http://purl.obolibrary.org/obo/CL_4023163) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SBC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31881018"
-- [trachea cartilage](http://purl.obolibrary.org/obo/UBERON_0003604) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-trachea.glb"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [trachea cartilage](http://purl.obolibrary.org/obo/UBERON_0003604) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb"
-- [trachea cartilage](http://purl.obolibrary.org/obo/UBERON_0003604) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb"
+### spinal cord development `http://purl.obolibrary.org/obo/GO_0021510`
+#### Removed
+- [spinal cord development](http://purl.obolibrary.org/obo/GO_0021510) SubClassOf [animal organ development](http://purl.obolibrary.org/obo/GO_0048513)
+
+#### Added
+- [spinal cord development](http://purl.obolibrary.org/obo/GO_0021510) SubClassOf [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856)
-### tracheal submucosal gland ciliated duct `http://purl.obolibrary.org/obo/UBERON_8600011`
+### stomach development `http://purl.obolibrary.org/obo/GO_0062094`
+#### Removed
+- [stomach development](http://purl.obolibrary.org/obo/GO_0062094) SubClassOf [animal organ development](http://purl.obolibrary.org/obo/GO_0048513)
#### Added
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [stomach development](http://purl.obolibrary.org/obo/GO_0062094) SubClassOf [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [date](http://purl.org/dc/terms/date) "2023-05-02T08:08:14Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
+### striosomal D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030048`
+#### Removed
+- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1S"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+
+- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-striosome"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated duct part of a tracheal submucosal gland."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30864819"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.cub.2021.10.015"
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [label](http://www.w3.org/2000/01/rdf-schema#label) "tracheal submucosal gland ciliated duct"
+- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D1-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8600011"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+#### Added
+- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-striosome"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.cub.2021.10.015"
-- Class: [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011)
+- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1S"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) EquivalentTo [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [trachea gland](http://purl.obolibrary.org/obo/UBERON_0005203))
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [trachea gland](http://purl.obolibrary.org/obo/UBERON_0005203)
+- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D1-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [tracheal submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600011) SubClassOf [submucosal gland ciliated duct](http://purl.obolibrary.org/obo/UBERON_8600014)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### tracheobronchial serous cell `http://purl.obolibrary.org/obo/CL_0019001`
+### striosomal D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030049`
#### Removed
-- [tracheobronchial serous cell](http://purl.obolibrary.org/obo/CL_0019001) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-striosome"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D2-MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### transit amplifying cell `http://purl.obolibrary.org/obo/CL_0009010`
-#### Removed
-- [transit amplifying cell](http://purl.obolibrary.org/obo/CL_0009010) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-#### Added
-- [transit amplifying cell](http://purl.obolibrary.org/obo/CL_0009010) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2S"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### transit amplifying cell of anorectum `http://purl.obolibrary.org/obo/CL_0009056`
-#### Removed
-- [transit amplifying cell of anorectum](http://purl.obolibrary.org/obo/CL_0009056) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+#### Added
+- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D2-MSN"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-striosome"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-### transit amplifying cell of appendix `http://purl.obolibrary.org/obo/CL_0009027`
-#### Removed
-- [transit amplifying cell of appendix](http://purl.obolibrary.org/obo/CL_0009027) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2S"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### transit amplifying cell of colon `http://purl.obolibrary.org/obo/CL_0009011`
-#### Removed
-- [transit amplifying cell of colon](http://purl.obolibrary.org/obo/CL_0009011) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+### synapsed by `http://purl.obolibrary.org/obo/RO_0002103`
+#### Removed
+- [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
+- [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between an anatomical structure and a neuron that chemically synapses to it."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-### transit amplifying cell of small intestine `http://purl.obolibrary.org/obo/CL_0009012`
-#### Removed
-- [transit amplifying cell of small intestine](http://purl.obolibrary.org/obo/CL_0009012) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
-### transitional epithelial cell `http://purl.obolibrary.org/obo/CL_0000244`
+### synapsed to `http://purl.obolibrary.org/obo/RO_0002120`
#### Removed
-- [transitional epithelial cell](http://purl.obolibrary.org/obo/CL_0000244) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and an anatomical structure that it chemically synapses to."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+- [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RO:0002120"
+- [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
-### transporting cell `http://purl.obolibrary.org/obo/CL_0000627`
-#### Removed
-- [transporting cell](http://purl.obolibrary.org/obo/CL_0000627) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) [id](http://www.geneontology.org/formats/oboInOwl#id) "synapsed_to"
+
+- [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "fly_anatomy.ontology"
-#### Added
-- [transporting cell](http://purl.obolibrary.org/obo/CL_0000627) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
-### transverse colon `http://purl.obolibrary.org/obo/UBERON_0001157`
+### syncytiotrophoblast `http://purl.obolibrary.org/obo/UBERON_0000371`
#### Added
-- [transverse colon](http://purl.obolibrary.org/obo/UBERON_0001157) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0000371"
-- [transverse colon](http://purl.obolibrary.org/obo/UBERON_0001157) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:83040"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:16068"
-### trigone of urinary bladder `http://purl.obolibrary.org/obo/UBERON_0001257`
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:256965005"
-#### Added
-- [trigone of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001257) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urinary_Bladder.glb"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C33918"
-- [trigone of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001257) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Urinary_Bladder.glb"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "syntrophoblast layer"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0073040584"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray36.png"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### type-1 epithelial cell of thymus `http://purl.obolibrary.org/obo/CL_0002294`
-#### Removed
-- [type-1 epithelial cell of thymus](http://purl.obolibrary.org/obo/CL_0002294) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "subcapsular thymic epithelial cell"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-#### Added
-- [type-1 epithelial cell of thymus](http://purl.obolibrary.org/obo/CL_0002294) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "subcapsular thymic epithelial cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:2694455"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "syncitiotrophoblast"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18194204"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "syncitiotrophoblastus"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Syncytiotrophoblast"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-### umbilical artery `http://purl.obolibrary.org/obo/UBERON_0001310`
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C1135936"
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Syncytiotrophoblast"
-#### Added
-- [umbilical artery](http://purl.obolibrary.org/obo/UBERON_0001310) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Syncytiotrophoblast"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA:91"
-### umbilical cord `http://purl.obolibrary.org/obo/UBERON_0002331`
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Syncytiotrophoblast"
-#### Added
-- [umbilical cord](http://purl.obolibrary.org/obo/UBERON_0002331) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://embryology.med.unsw.edu.au/Notes/placenta5.htm"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA:129"
-### umbilical vein `http://purl.obolibrary.org/obo/UBERON_0002066`
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001335"
-#### Added
-- [umbilical vein](http://purl.obolibrary.org/obo/UBERON_0002066) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Placenta.glb"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [label](http://www.w3.org/2000/01/rdf-schema#label) "syncytiotrophoblast"
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "syntrophoblast"
-### uncurated `http://purl.obolibrary.org/obo/IAO_0000124`
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "syncytial trophoblast"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:83040"
-#### Added
-- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en
+- Class: [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371)
-- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [label](http://www.w3.org/2000/01/rdf-schema#label) "uncurated"@en
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ectoplacental cone](http://purl.obolibrary.org/obo/UBERON_0004364)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "EMAPA"
-- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "uncurated"@en
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) SubClassOf [composed primarily of](http://purl.obolibrary.org/obo/RO_0002473) some [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525)
-- Individual: [uncurated](http://purl.obolibrary.org/obo/IAO_0000124)
+- [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371) SubClassOf [embryonic structure](http://purl.obolibrary.org/obo/UBERON_0002050)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
-### universal `http://purl.obolibrary.org/obo/IAO_0000410`
+### syncytiotrophoblast cell `http://purl.obolibrary.org/obo/CL_0000525`
+#### Removed
+- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) SubClassOf [placental villous trophoblast](http://purl.obolibrary.org/obo/CL_2000060)
#### Added
-- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
-
-- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [label](http://www.w3.org/2000/01/rdf-schema#label) "universal"@en
+- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [syncytiotrophoblast](http://purl.obolibrary.org/obo/UBERON_0000371)
-- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf"@en
+- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) SubClassOf [trophoblast cell](http://purl.obolibrary.org/obo/CL_0000351)
-- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents."@en
-- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "universal"@en
-
-- Individual: [universal](http://purl.obolibrary.org/obo/IAO_0000410)
+### tissue remodeling `http://purl.obolibrary.org/obo/GO_0048771`
+#### Added
+- [tissue remodeling](http://purl.obolibrary.org/obo/GO_0048771) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "tissue remodelling"
-### ureteral cell `http://purl.obolibrary.org/obo/CL_1000601`
-#### Removed
-- [ureteral cell](http://purl.obolibrary.org/obo/CL_1000601) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ureter](http://purl.obolibrary.org/obo/UBERON_0000056))
-- [ureteral cell](http://purl.obolibrary.org/obo/CL_1000601) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+### tissue-resident macrophage `http://purl.obolibrary.org/obo/CL_0000864`
#### Added
-- [ureteral cell](http://purl.obolibrary.org/obo/CL_1000601) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ureter](http://purl.obolibrary.org/obo/UBERON_0000056))
+- [tissue-resident macrophage](http://purl.obolibrary.org/obo/CL_0000864) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [ureteral cell](http://purl.obolibrary.org/obo/CL_1000601) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [tissue-resident macrophage](http://purl.obolibrary.org/obo/CL_0000864) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-### urethra cell `http://purl.obolibrary.org/obo/CL_1001320`
+### title `http://purl.org/dc/terms/title`
#### Removed
-- [urethra cell](http://purl.obolibrary.org/obo/CL_1001320) EquivalentTo [animal cell](http://purl.obolibrary.org/obo/CL_0000548) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [urethra](http://purl.obolibrary.org/obo/UBERON_0000057))
+- AnnotationProperty: [title](http://purl.org/dc/terms/title)
-#### Added
-- [urethra cell](http://purl.obolibrary.org/obo/CL_1001320) EquivalentTo [cell](http://purl.obolibrary.org/obo/CL_0000000) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [urethra](http://purl.obolibrary.org/obo/UBERON_0000057))
-### urinary bladder `http://purl.obolibrary.org/obo/UBERON_0001255`
+### tracheal epithelial cell `http://purl.obolibrary.org/obo/CL_0000307`
+#### Removed
+- [tracheal epithelial cell](http://purl.obolibrary.org/obo/CL_0000307) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-#### Added
-- [urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001255) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Urinary_Bladder.glb"
+- [tracheal epithelial cell](http://purl.obolibrary.org/obo/CL_0000307) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001255) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urinary_Bladder.glb"
-### urinary bladder neck smooth muscle `http://purl.obolibrary.org/obo/UBERON_0004230`
+### tracheobronchial goblet cell `http://purl.obolibrary.org/obo/CL_0019003`
#### Added
-- [urinary bladder neck smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004230) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Urinary_Bladder.glb"
+- [tracheobronchial goblet cell](http://purl.obolibrary.org/obo/CL_0019003) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [urinary bladder neck smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004230) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Urinary_Bladder.glb"
+- [tracheobronchial goblet cell](http://purl.obolibrary.org/obo/CL_0019003) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### uterine cervix `http://purl.obolibrary.org/obo/UBERON_0000002`
+### transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0022857`
#### Added
-- [uterine cervix](http://purl.obolibrary.org/obo/UBERON_0000002) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Uterus.glb"
+- [transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022857) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-434650"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "MATEs mediate extrusion of xenobiotics"
-### uterus `http://purl.obolibrary.org/obo/UBERON_0000995`
+### transmitter-gated channel activity `http://purl.obolibrary.org/obo/GO_0022835`
+#### Removed
+- [transmitter-gated channel activity](http://purl.obolibrary.org/obo/GO_0022835) EquivalentTo [channel activity](http://purl.obolibrary.org/obo/GO_0015267) and ([regulated by](http://purl.obolibrary.org/obo/RO_0002334) some [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165))
-#### Added
-- [uterus](http://purl.obolibrary.org/obo/UBERON_0000995) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Uterus.glb"
+- [transmitter-gated channel activity](http://purl.obolibrary.org/obo/GO_0022835) SubClassOf [regulated by](http://purl.obolibrary.org/obo/RO_0002334) some [neurotransmitter binding](http://purl.obolibrary.org/obo/GO_0042165)
-### valve `http://purl.obolibrary.org/obo/UBERON_0003978`
-#### Added
-- [valve](http://purl.obolibrary.org/obo/UBERON_0003978) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb"
+### transporter activity `http://purl.obolibrary.org/obo/GO_0005215`
+#### Removed
+- [transporter activity](http://purl.obolibrary.org/obo/GO_0005215) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-178215"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "SMAD7:SMURF1 complex is exported to the cytosol"
+
+- [transporter activity](http://purl.obolibrary.org/obo/GO_0005215) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-168313"
+ - [label](http://www.w3.org/2000/01/rdf-schema#label) "Virion-associated M2 protein mediated ion infusion"
-- [valve](http://purl.obolibrary.org/obo/UBERON_0003978) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb"
-### vasculature of eye `http://purl.obolibrary.org/obo/UBERON_0002203`
+### umbrella cell of urothelium `http://purl.obolibrary.org/obo/CL_4030056`
#### Added
-- [vasculature of eye](http://purl.obolibrary.org/obo/UBERON_0002203) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [vasculature of eye](http://purl.obolibrary.org/obo/UBERON_0002203) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### vena cava `http://purl.obolibrary.org/obo/UBERON_0004087`
+### ureter smooth muscle cell `http://purl.obolibrary.org/obo/CL_1000979`
#### Added
-- [vena cava](http://purl.obolibrary.org/obo/UBERON_0004087) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb"
+- [ureter smooth muscle cell](http://purl.obolibrary.org/obo/CL_1000979) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [vena cava](http://purl.obolibrary.org/obo/UBERON_0004087) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb"
+- [ureter smooth muscle cell](http://purl.obolibrary.org/obo/CL_1000979) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### venous blood vessel `http://purl.obolibrary.org/obo/UBERON_0003920`
+### ureteric bud cell `http://purl.obolibrary.org/obo/CL_4030066`
#### Added
-- [venous blood vessel](http://purl.obolibrary.org/obo/UBERON_0003920) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) [date](http://purl.org/dc/terms/date) "2023-10-13T11:22:42Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [venous blood vessel](http://purl.obolibrary.org/obo/UBERON_0003920) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) [contributor](http://purl.org/dc/terms/contributor) "https://orcid.org/0000-0002-1425-877X"
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "UB cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
-### vermiform appendix `http://purl.obolibrary.org/obo/UBERON_0001154`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24183650"
-#### Added
-- [vermiform appendix](http://purl.obolibrary.org/obo/UBERON_0001154) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb"
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17133361"
-- [vermiform appendix](http://purl.obolibrary.org/obo/UBERON_0001154) [depiction](http://xmlns.com/foaf/0.1/depiction) "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24183650"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9374839"
-### vertebrate lens cell `http://purl.obolibrary.org/obo/CL_0002222`
-#### Removed
-- [vertebrate lens cell](http://purl.obolibrary.org/obo/CL_0002222) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) [label](http://www.w3.org/2000/01/rdf-schema#label) "ureteric bud cell"
+- Class: [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) EquivalentTo [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ureteric bud](http://purl.obolibrary.org/obo/UBERON_0000084))
-### vestibular dark cell `http://purl.obolibrary.org/obo/CL_0000846`
-#### Removed
-- [vestibular dark cell](http://purl.obolibrary.org/obo/CL_0000846) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) SubClassOf [participates in](http://purl.obolibrary.org/obo/RO_0000056) some [epithelial cell proliferation involved in renal tubule morphogenesis](http://purl.obolibrary.org/obo/GO_2001013)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9374839"
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ureteric bud](http://purl.obolibrary.org/obo/UBERON_0000084)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) SubClassOf [duct epithelial cell](http://purl.obolibrary.org/obo/CL_0000068)
-### visual pigment cell `http://purl.obolibrary.org/obo/CL_0000149`
-#### Removed
-- [visual pigment cell](http://purl.obolibrary.org/obo/CL_0000149) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+- [ureteric bud cell](http://purl.obolibrary.org/obo/CL_4030066) SubClassOf [kidney epithelial cell](http://purl.obolibrary.org/obo/CL_0002518)
+### valve endothelial cell `http://purl.obolibrary.org/obo/CL_4030033`
+#### Removed
+- [valve endothelial cell](http://purl.obolibrary.org/obo/CL_4030033) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "VEC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25311230"
-### wavy bistratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004239`
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30796046"
#### Added
-- [wavy bistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004239) SubClassOf [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252)
+- [valve endothelial cell](http://purl.obolibrary.org/obo/CL_4030033) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "VEC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25311230"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30796046"
-### white fat cell `http://purl.obolibrary.org/obo/CL_0000448`
+
+### valve interstitial cell `http://purl.obolibrary.org/obo/CL_4030032`
#### Removed
-- [white fat cell](http://purl.obolibrary.org/obo/CL_0000448) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "white fat cell"
+- [valve interstitial cell](http://purl.obolibrary.org/obo/CL_4030032) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "VIC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25311230"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30796046"
-### xanthoblast `http://purl.obolibrary.org/obo/CL_0005002`
-#### Removed
-- [xanthoblast](http://purl.obolibrary.org/obo/CL_0005002) SubClassOf [animal cell](http://purl.obolibrary.org/obo/CL_0000548)
+#### Added
+- [valve interstitial cell](http://purl.obolibrary.org/obo/CL_4030032) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+- [valve interstitial cell](http://purl.obolibrary.org/obo/CL_4030032) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+
+- [valve interstitial cell](http://purl.obolibrary.org/obo/CL_4030032) [has exact synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "VIC"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25311230"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30796046"
-### zygote `http://purl.obolibrary.org/obo/CL_0010017`
+
+### von Economo neuron `http://purl.obolibrary.org/obo/CL_4030039`
#### Removed
-- [zygote](http://purl.obolibrary.org/obo/CL_0010017) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003)
+- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "VEN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32127543"
#### Added
-- [zygote](http://purl.obolibrary.org/obo/CL_0010017) SubClassOf [cell](http://purl.obolibrary.org/obo/CL_0000000)
+- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "VEN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/OMO_0003000)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32127543"
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.json b/src/ontology/subsets/blood_and_immune_upper_slim.json
index 3339a4738..98bbc3116 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.json
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-09-21"
+ "val" : "2023-10-19"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-09-21/subsets/blood_and_immune_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-10-19/subsets/blood_and_immune_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -296,9 +296,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "occurs_in"
@@ -724,168 +721,6 @@
"val" : "in_dorsal_side_of"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "lbl" : "anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
- "xrefs" : [ "CAROC:Brownsville2014" ]
- },
- "comments" : [ "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "lbl" : "connected anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
- },
- "comments" : [ "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "lbl" : "material anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical entity that has mass."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "lbl" : "multicellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
- },
- "comments" : [ "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "lbl" : "gross anatomical part",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#plus" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "10.7.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "lbl" : "organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- },
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "organism or virus or viroid"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "Melissa Haendel"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "9/18/11"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "lbl" : "multicellular anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical structure that has more than one cell as a part."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "djs93"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "Sun Feb 27 10:53:00 GMT 2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "lbl" : "cellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An individual member of a clade of cellular organisms."
- },
- "comments" : [ "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. " ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "7.16.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "lbl" : "biological entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
- },
- "comments" : [ "Important for alignment with Darwin Core class \"Organism\"." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_50860",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any molecular entity that contains carbon.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "organic compounds",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic entity",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic molecular entities",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000000",
"lbl" : "cell",
@@ -970,7 +805,7 @@
"pred" : "hasExactSynonym",
"val" : "hemopoietic stem cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HSC"
}, {
@@ -1006,11 +841,11 @@
},
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BFU-E"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-E"
}, {
@@ -1041,7 +876,7 @@
},
"comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-M"
}, {
@@ -1101,17 +936,17 @@
"pred" : "hasExactSynonym",
"val" : "common myeloid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GEMM",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-S",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CMP",
"xrefs" : [ "ISBN:0878932437" ]
@@ -1199,11 +1034,11 @@
"pred" : "hasExactSynonym",
"val" : "common lymphoid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CLP"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "ELP"
}, {
@@ -1342,7 +1177,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"
} ]
}
@@ -1601,15 +1436,15 @@
"val" : "marrow stromal cells",
"xrefs" : [ "PMID:11378515" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BMSC"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-F"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "MSC",
"xrefs" : [ "PMID:11378515" ]
@@ -1661,7 +1496,7 @@
"comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ],
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "APC"
} ]
@@ -1675,15 +1510,10 @@
"val" : "A cell that specializes in controlled release of one or more substances.",
"xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "BTO:0003659"
}, {
"val" : "FMA:86916"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1726,7 +1556,7 @@
"val" : "WBbt:0003675"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg"
} ]
}
@@ -2218,7 +2048,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg"
} ]
}
@@ -2495,12 +2325,12 @@
"pred" : "hasExactSynonym",
"val" : "granulocyte/monocyte progenitor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GM",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "GMP",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
@@ -2559,17 +2389,12 @@
"xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
},
"comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "angioblast"
}, {
"pred" : "hasExactSynonym",
"val" : "chondroplast"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -2786,12 +2611,7 @@
"definition" : {
"val" : "A cell of the monocyte, granulocyte, or mast cell lineage.",
"xrefs" : [ "GOC:add" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000767",
@@ -2944,7 +2764,6 @@
"xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ]
},
"comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasBroadSynonym",
"val" : "interdigitating cell"
@@ -2960,10 +2779,6 @@
} ],
"xrefs" : [ {
"val" : "BTO:0004721"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -3120,7 +2935,7 @@
"pred" : "hasExactSynonym",
"val" : "gammadelta T cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "gd T cell"
} ],
@@ -4023,7 +3838,6 @@
"val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.",
"xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "CALOHA:TS-2096"
}, {
@@ -4032,9 +3846,6 @@
"val" : "MESH:D003239"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- }, {
"pred" : "http://purl.org/dc/terms/contributor",
"val" : "https://orcid.org/0000-0003-1980-3228"
}, {
@@ -4220,9 +4031,14 @@
"definition" : {
"val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
},
+ "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "mesenchyme cell"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -11531,7 +11347,7 @@
"pred" : "hasExactSynonym",
"val" : "non-membrane-enclosed organelle"
}, {
- "pred" : "hasNarrowSynonym",
+ "pred" : "hasRelatedSynonym",
"val" : "biological condensate"
} ],
"xrefs" : [ {
@@ -12231,6 +12047,9 @@
"val" : "Wikipedia:Organogenesis"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/25943"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -12535,6 +12354,10 @@
"xrefs" : [ "GOC:ebc" ]
},
"subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "synonyms" : [ {
+ "pred" : "hasExactSynonym",
+ "val" : "tissue remodelling"
+ } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
@@ -13023,13 +12846,16 @@
"val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.",
"xrefs" : [ "GOC:ai", "GOC:dos" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "establishment of localisation",
"xrefs" : [ "GOC:mah" ]
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -14462,8 +14288,11 @@
"val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
"xrefs" : [ "GOC:kmv" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
"val" : "kmv"
}, {
@@ -15011,7 +14840,7 @@
"val" : "http://purl.obolibrary.org/obo/IAO_0000122"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
- "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "PERSON:Daniel Schober"
@@ -16217,6 +16046,28 @@
"val" : "https://orcid.org/0000-0002-8688-6599"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/OMO_0003000",
+ "lbl" : "abbreviation",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A synonym type for describing abbreviations or initalisms"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/information-artifact-ontology/ontology-metadata/issues/122"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-4423-4370"
+ }, {
+ "pred" : "http://purl.org/dc/terms/created",
+ "val" : "2023-03-03"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/OMO_0003004",
"lbl" : "plural form",
@@ -16245,13 +16096,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.",
+ "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities",
"xrefs" : [ "PATOC:GVG" ]
},
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "trait"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
"val" : "PATO:0000072"
@@ -16339,22 +16186,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "lbl" : "mass",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.",
- "xrefs" : [ "PATOC:GVG" ]
- },
- "comments" : [ "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/pato#attribute_slim", "http://purl.obolibrary.org/obo/pato#relational_slim", "http://purl.obolibrary.org/obo/pato#scalar_slim" ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0000141",
"lbl" : "structure",
@@ -16574,9 +16405,6 @@
}, {
"pred" : "hasExactSynonym",
"val" : "multiply inhering quality of a physical entity"
- }, {
- "pred" : "hasExactSynonym",
- "val" : "multiply inhering quality of a physical entity "
}, {
"pred" : "hasExactSynonym",
"val" : "quality of a continuant"
@@ -17331,27 +17159,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "lbl" : "maximally connected",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.",
- "xrefs" : [ "GOC:dos" ]
- },
- "comments" : [ "What counts as maximally connected may be relative to some specification of granularity." ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-7073-9172"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
- "val" : "2014-12-12T08:41:11Z"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0010001",
"lbl" : "disconnected",
@@ -21063,7 +20870,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002000",
- "lbl" : "boundary_of",
+ "lbl" : "2D boundary of",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -21100,7 +20907,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002002",
- "lbl" : "has_boundary",
+ "lbl" : "has 2D boundary",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -21499,12 +21306,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a neuron and a material anatomical entity that its soma is part of."
},
- "xrefs" : [ {
- "val" : "RO:0002100"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21514,15 +21317,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some (\n and some ?Y)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21533,9 +21330,6 @@
"definition" : {
"val" : "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"
},
- "xrefs" : [ {
- "val" : "RO:0002101"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21554,9 +21348,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21593,8 +21384,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between an anatomical structure and a neuron that chemically synapses to it.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "
},
"xrefs" : [ {
"val" : "RO:0002103"
@@ -21611,18 +21401,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that has_part some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -21673,10 +21457,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "
},
- "comments" : [ "Relation between a neuron and the structure in which its dendrite receives synapses." ],
- "xrefs" : [ {
- "val" : "RO:0002110"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21689,9 +21469,6 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "synapsed in"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))"
@@ -21701,9 +21478,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21714,9 +21488,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."
},
- "xrefs" : [ {
- "val" : "RO:0002113"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21726,18 +21497,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21746,13 +21511,9 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that it chemically synapses to.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n "
},
"comments" : [ "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ],
- "xrefs" : [ {
- "val" : "RO:0002120"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21765,18 +21526,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21785,13 +21540,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
},
- "comments" : [ "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)" ],
- "xrefs" : [ {
- "val" : "RO:0002130"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21804,18 +21554,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21884,8 +21628,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."
},
"xrefs" : [ {
"val" : "RO:0002134"
@@ -21899,18 +21642,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that ( some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -22535,9 +22272,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "regulates"
@@ -22570,9 +22304,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "negatively_regulates"
@@ -22605,9 +22336,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "positively_regulates"
@@ -26273,6 +26001,47 @@
"val" : "https://orcid.org/0000-0003-4639-4431"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "lbl" : "has small molecule regulator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:27:26Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "lbl" : "has small molecule activator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
+ },
+ "xrefs" : [ {
+ "val" : "RO:0012001"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:28:37Z"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
+ "val" : "external"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
+ "val" : "has_small_molecule_activator"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012003",
"lbl" : "acts on population of",
@@ -26299,6 +26068,41 @@
"val" : "acts_on_population_of"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "lbl" : "is small molecule regulator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:17Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "lbl" : "is small molecule activator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:26Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_small_molecule_activator_of"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012008",
"lbl" : "results in fusion of",
@@ -36744,19 +36548,6 @@
"val" : "uberon"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/cl#abbreviation",
- "lbl" : "abbreviation",
- "type" : "PROPERTY",
- "meta" : {
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/elements/1.1/date",
- "val" : "2022-03-29T15:09:49Z"
- }, {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-1773-2692"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim",
"lbl" : "blood_and_immune_upper_slim",
@@ -37319,25 +37110,6 @@
"val" : "seeAlso"
} ]
}
- }, {
- "id" : "http://xmlns.com/foaf/0.1/depicted_by",
- "lbl" : "depicted by",
- "type" : "PROPERTY",
- "meta" : {
- "xrefs" : [ {
- "val" : "http://xmlns.com/foaf/0.1/depicted_by"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "uberon"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag",
- "val" : "true"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
- "val" : "depicted_by"
- } ]
- }
} ],
"edges" : [ {
"sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
@@ -37359,74 +37131,6 @@
"sub" : "http://purl.obolibrary.org/obo/BFO_0000141",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0030000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0010000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000125"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000012"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001008"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001993"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001010"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000000",
"pred" : "is_a",
@@ -42451,10 +42155,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0042221",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0050896"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0042221",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002233",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0042246",
"pred" : "is_a",
@@ -42839,10 +42539,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0048513",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0048856"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0048513",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002296",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0048518",
"pred" : "is_a",
@@ -43399,10 +43095,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0071704",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0008152"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0071704",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004007",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0071707",
"pred" : "is_a",
@@ -43579,10 +43271,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0098657",
"pred" : "http://purl.obolibrary.org/obo/RO_0002339",
"obj" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0098657",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0098793",
"pred" : "is_a",
@@ -43691,10 +43379,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0099537",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0099536"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0110165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0110165",
"pred" : "is_a",
@@ -43775,10 +43459,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_1901576",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0071704"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_1901576",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004008",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_1902105",
"pred" : "is_a",
@@ -44019,10 +43699,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0000117",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001018"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0000141",
"pred" : "is_a",
@@ -44235,10 +43911,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0002505",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0001404"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000141"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0010001",
"pred" : "is_a",
@@ -44667,10 +44339,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002497",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
"pred" : "is_a",
@@ -49147,10 +48815,30 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0011002",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012000"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012003",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002596"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002598"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012008",
"pred" : "subPropertyOf",
@@ -49455,36 +49143,20 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0003000",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012005"
}, {
"sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to"
} ],
"logicalDefinitionAxioms" : [ {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010000"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0000125"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001993"
- } ]
- }, {
"definedClassId" : "http://purl.obolibrary.org/obo/CL_0000034",
"genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ],
"restrictions" : [ {
@@ -51733,13 +51405,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002233",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000236"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042221",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002233",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0042246",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0031099" ],
@@ -51887,13 +51552,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000000"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048513",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
- "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0048518",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -52174,13 +51832,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002588",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0043226"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071704",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0071826",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ],
@@ -52244,19 +51895,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005604"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098657",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002338",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0098796",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ],
@@ -52370,13 +52008,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901576",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_1902105",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -53156,7 +52787,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002002",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040", "http://purl.obolibrary.org/obo/CARO_0000003" ],
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.obo b/src/ontology/subsets/blood_and_immune_upper_slim.obo
index 999f7eb2e..d86db0c8b 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.obo
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-09-21/subsets/blood_and_immune_upper_slim.owl
+data-version: cl/releases/2023-10-19/subsets/blood_and_immune_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,13 +82,12 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/blood_and_immune_upper_slim
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -147,106 +138,6 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:24431
-namespace: chebi_ontology
-def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [ANON:ANON]
-is_a: BFO:0000040 ! material entity
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -301,7 +192,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -347,10 +238,10 @@ id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
-synonym: "BFU-E" RELATED abbreviation []
+synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
-synonym: "CFU-E" RELATED abbreviation []
+synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
@@ -363,7 +254,7 @@ id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
-synonym: "CFU-M" RELATED abbreviation []
+synonym: "CFU-M" RELATED OMO:0003000 []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
@@ -405,9 +296,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -451,13 +342,13 @@ name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: human_reference_atlas
-synonym: "CLP" RELATED abbreviation []
+synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
-synonym: "ELP" RELATED abbreviation []
+synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
@@ -530,7 +421,7 @@ is_a: CL:0000000 ! cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000071
@@ -736,9 +627,9 @@ id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -746,7 +637,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -761,7 +652,7 @@ name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
-synonym: "APC" RELATED abbreviation []
+synonym: "APC" RELATED OMO:0003000 []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
@@ -771,14 +662,12 @@ relationship: capable_of GO:0002504 ! antigen processing and presentation of pep
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000183
@@ -801,7 +690,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -1154,7 +1043,7 @@ is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000542
@@ -1365,9 +1254,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: human_reference_atlas
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
-synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
-synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
@@ -1458,7 +1347,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -1469,7 +1357,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -1657,12 +1544,10 @@ relationship: has_part GO:0005634 ! nucleus
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
-subset: human_reference_atlas
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000767
@@ -1758,7 +1643,6 @@ id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
-subset: human_reference_atlas
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
@@ -1771,7 +1655,6 @@ intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleuki
intersection_of: develops_from CL:0000763 ! myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000763 ! myeloid cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000784
@@ -1874,7 +1757,7 @@ synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
-synonym: "gd T cell" RELATED abbreviation []
+synonym: "gd T cell" RELATED OMO:0003000 []
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
@@ -2608,7 +2491,6 @@ creation_date: 2010-09-15T01:34:57Z
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -2617,7 +2499,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -2733,10 +2614,12 @@ is_a: CL:0000988 ! hematopoietic cell
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0010017
@@ -6500,9 +6383,6 @@ subset: goslim_yeast
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus
-intersection_of: GO:0050896 ! response to stimulus
-intersection_of: has_input CHEBI:24431
-relationship: has_input CHEBI:24431
[Term]
id: GO:0042246
@@ -6685,7 +6565,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -7076,9 +6956,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048518
@@ -7253,6 +7131,7 @@ name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
+synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process
[Term]
@@ -7538,12 +7417,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051239
@@ -7931,9 +7812,6 @@ synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:50860
-relationship: has_primary_input_or_output CHEBI:50860
created_by: mah
creation_date: 2010-03-08T03:32:18Z
@@ -8210,11 +8088,6 @@ namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport
-intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:24431
-intersection_of: has_target_end_location GO:0005737 ! cytoplasm
-intersection_of: has_target_start_location GO:0005576 ! extracellular region
-relationship: has_primary_input CHEBI:24431
relationship: has_target_end_location GO:0005737 ! cytoplasm
relationship: has_target_start_location GO:0005576 ! extracellular region
@@ -8353,10 +8226,11 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -8473,9 +8347,6 @@ synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:50860
-relationship: has_primary_output CHEBI:50860
created_by: pr
creation_date: 2012-11-05T11:04:40Z
@@ -8939,8 +8810,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -8986,17 +8855,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000141
name: structure
@@ -9109,7 +8967,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -9501,16 +9358,6 @@ is_a: PATO:0001404 ! nucleate quality
relationship: dc-contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -10952,7 +10799,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological_process
@@ -11233,7 +11079,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -11385,7 +11231,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -11478,7 +11324,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -11938,7 +11784,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -11969,7 +11815,7 @@ is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: has_part CL:0000076 ! squamous epithelial cell
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"}
[Term]
@@ -12067,7 +11913,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -12142,7 +11988,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -12182,8 +12028,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -12229,7 +12075,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -12268,7 +12114,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -12436,7 +12282,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -12518,7 +12364,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073
relationship: never_in_taxon NCBITaxon:6157
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -12559,7 +12405,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -12615,8 +12461,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -12740,7 +12586,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -13038,7 +12884,7 @@ relationship: has_part CL:0000071 {source="AEO"} ! blood vessel endothelial cell
relationship: has_part UBERON:0007500 {source="EHDAA2"} ! epithelial tube open at both ends
relationship: has_quality PATO:0002045 ! dendritic
relationship: part_of UBERON:0004537 ! blood vasculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011004", ontology="AAO", source="AAO:EJS"}
@@ -13093,7 +12939,7 @@ relationship: composed_primarily_of UBERON:0000055 ! vessel
relationship: has_part UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0007798 ! vascular system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "see also: vascular system. Consider merging?" xsd:string
property_value: UBPROP:0000007 "vascular" xsd:string
@@ -13325,8 +13171,8 @@ intersection_of: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0002323 ! coelemic cavity lumen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" xsd:string
[Term]
@@ -13412,7 +13258,7 @@ relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -13461,7 +13307,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -13510,8 +13356,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -13601,7 +13447,7 @@ relationship: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0002390 {source="FMA", source="MA"} ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string
property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string
property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"}
@@ -13813,7 +13659,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -13920,7 +13766,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -13957,7 +13803,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -13991,7 +13837,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -14029,7 +13875,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -14086,7 +13932,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -14146,7 +13992,7 @@ intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -14971,7 +14817,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -16115,7 +15961,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -16127,7 +15972,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -16231,10 +16076,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -16243,15 +16085,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -16295,10 +16133,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -16309,15 +16144,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -16325,34 +16157,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -16361,7 +16184,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -16530,7 +16352,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -16581,7 +16403,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -16789,7 +16611,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -16879,7 +16701,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -17136,6 +16958,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -17267,7 +17116,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -17315,7 +17164,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -17393,7 +17242,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -17636,13 +17485,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -17977,7 +17819,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -17989,7 +17830,6 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
is_a: RO:0002323 ! mereotopologically related to
@@ -18115,7 +17955,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -18305,12 +18145,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -18554,17 +18405,14 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -18607,8 +18455,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -18664,7 +18512,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -18713,7 +18560,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -18773,7 +18619,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -18847,7 +18693,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19033,7 +18878,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19423,10 +19267,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -19435,7 +19277,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.owl b/src/ontology/subsets/blood_and_immune_upper_slim.owl
index 4c19bb7a1..b217aab43 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.owl
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.owl
@@ -10,10 +10,8 @@
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
- xmlns:caro="http://purl.obolibrary.org/obo/caro#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
- xmlns:fbbt="http://purl.obolibrary.org/obo/fbbt#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo2="http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/"
xmlns:pato="http://purl.obolibrary.org/obo/pato#"
@@ -31,8 +29,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-09-21
+
+ 2023-10-19
@@ -99,7 +97,7 @@ We don't have definitions of 'meaning' or 'expression'
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
@@ -273,18 +271,6 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
-
-
-
-
-
-
-
-
-
-
-
-
@@ -315,6 +301,19 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
+
+
+
+ CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
+ A synonym type for describing abbreviations or initalisms
+
+
+ 2023-03-03
+ abbreviation
+
+
+
+
@@ -675,22 +674,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -699,17 +682,6 @@ WHERE {
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -749,46 +721,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1043,14 +975,6 @@ WHERE {
-
-
-
-
-
-
-
-
@@ -1547,12 +1471,6 @@ WHERE {
-
-
-
-
-
-
@@ -2016,14 +1934,7 @@ WHERE {
-
- http://xmlns.com/foaf/0.1/depicted_by
- uberon
- depicted_by
- true
- depicted_by
- depicted by
-
+
@@ -2222,7 +2133,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
unfolds_in
BFO:0000066
external
- gene_ontology
occurs_in
@@ -2917,7 +2827,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
surface of
2D boundary of
- boundary_of
@@ -2927,7 +2836,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
-
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
@@ -2943,7 +2851,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
has_boundary
has 2D boundary
has 2D boundary
- has_boundary
@@ -3280,23 +3187,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and a material anatomical entity that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
- BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)
- RO:0002100
- fly_anatomy.ontology
- has_soma_location
has soma location
-
-
-
- Relation between a neuron and an anatomical structure that its soma is part of.
-
-
@@ -3307,7 +3203,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3334,17 +3229,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
))))))
- RO:0002101
- fly_anatomy.ontology
- fasciculates_with
fasciculates with
-
-
-
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
-
-
@@ -3390,27 +3276,18 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
- Relation between an anatomical structure and a neuron that chemically synapses to it.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))
RO:0002103
- fly_anatomy.ontology
uberon
synapsed_by
synapsed_by
synapsed by
synapsed by
-
-
-
- Relation between an anatomical structure and a neuron that chemically synapses to it.
-
-
@@ -3449,16 +3326,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
synapsed in
- BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))
http://purl.obolibrary.org/obo/BFO_0000051 some (
http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (
http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))
- RO:0002110
- fly_anatomy.ontology
- has_postsynaptic_terminals_in
- Relation between a neuron and the structure in which its dendrite receives synapses.
has postsynaptic terminal in
@@ -3477,12 +3349,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
synapses in
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))
- RO:0002113
- fly_anatomy.ontology
- has_presynaptic_terminals_in
has presynaptic terminal in
@@ -3506,16 +3374,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
- Relation between a neuron and an anatomical structure that it chemically synapses to.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))
- RO:0002120
- fly_anatomy.ontology
- synapsed_to
N1 synapsed_to some N2
Expands to:
N1 SubclassOf (
@@ -3525,12 +3388,6 @@ N1 SubclassOf (
‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
-
-
-
- Relation between a neuron and an anatomical structure that it chemically synapses to.
-
-
@@ -3545,25 +3402,13 @@ N1 SubclassOf (
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synapse in
<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)
- RO:0002130
- fly_anatomy.ontology
- has_synaptic_terminals_in
- expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
has synaptic terminal in
-
-
-
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
-
-
@@ -3675,26 +3520,17 @@ N1 SubclassOf (
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))
RO:0002134
- fly_anatomy.ontology
uberon
innervates
innervates
innervates
innervates
-
-
-
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
@@ -4174,7 +4010,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.false
RO:0002211
external
- gene_ontology
regulates
@@ -4203,7 +4038,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002212
external
- gene_ontology
negatively_regulates
@@ -4237,7 +4071,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002213
external
- gene_ontology
positively_regulates
@@ -7254,6 +7087,37 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is regulated by the small molecule continuant
+
+ 2020-04-22T20:27:26Z
+ has small molecule regulator
+
+
+
+
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is activated by the small molecule continuant
+
+ 2020-04-22T20:28:37Z
+ RO:0012001
+ external
+ has_small_molecule_activator
+ has_small_molecule_activator
+ has small molecule activator
+ has small molecule activator
+
+
+
+
@@ -7274,6 +7138,32 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process
+
+ 2020-06-24T13:15:17Z
+ is small molecule regulator of
+
+
+
+
+
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that activates the process
+
+ 2020-06-24T13:15:26Z
+ is small molecule activator of
+ https://wiki.geneontology.org/Is_small_molecule_activator_of
+
+
+
+
@@ -8031,256 +7921,6 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CARO:0000000
- Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
- anatomical entity
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CAROC:Brownsville2014
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
- CARO:0000003
-
- Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
- connected anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical entity that has mass.
- CARO:0000006
-
- material anatomical entity
-
-
-
-
-
-
-
-
- Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell.
- CARO:0000012
- MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-
-MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
- multicellular organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
-
- 10.7.2011
-
- gross anatomical part
-
-
-
-
-
-
-
-
- Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
- Melissa Haendel
- 9/18/11
- organism or virus or viroid
- organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical structure that has more than one cell as a part.
- djs93
- Sun Feb 27 10:53:00 GMT 2011
- CARO:0010000
-
- multicellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
-
-
-
-
-
-
-
-
-
- An individual member of a clade of cellular organisms.
-
- 7.16.2011
- CARO:0010004
- A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
- cellular organism
-
-
-
-
-
-
-
-
- Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them.
- Important for alignment with Darwin Core class "Organism".
- biological entity
-
-
-
-
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- chebi_ontology
- CHEBI:24431
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- ANON:ANON
-
-
-
-
-
-
-
- Any molecular entity that contains carbon.
- chebi_ontology
- organic compounds
- organic entity
- organic molecular entities
- CHEBI:50860
-
-
-
-
- Any molecular entity that contains carbon.
- ANON:ANON
-
-
-
-
- organic compounds
- ChEBI:
-
-
-
-
- organic entity
- ChEBI:
-
-
-
-
- organic molecular entities
- ChEBI:
-
-
-
-
@@ -8564,7 +8204,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
HSC
-
+
@@ -8608,13 +8248,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BFU-E
-
+
CFU-E
-
+
@@ -8711,7 +8351,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-M
-
+
@@ -8799,21 +8439,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -8967,13 +8607,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CLP
-
+
ELP
-
+
@@ -9097,7 +8737,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -9870,20 +9510,20 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -9946,7 +9586,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
APC
-
+
@@ -9973,10 +9613,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -10026,7 +9664,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -11023,7 +10661,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -12012,7 +11650,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -12021,7 +11659,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -12181,12 +11819,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
reticulocyte
-
-
-
-
- true
-
@@ -12196,6 +11828,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PMID:15946868
PMID:2037622
+
+
+
+
+ true
+
@@ -12316,10 +11954,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -13000,8 +12636,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the monocyte, granulocyte, or mast cell lineage.
-
-
myeloid leukocyte
@@ -13323,13 +12957,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dendritic cell of the myeloid lineage.
-
interdigitating cell
veiled cell
BTO:0004721
CD11c+CD123- DC
mDC
-
These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
myeloid dendritic cell
@@ -13693,7 +13325,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
gd T cell
-
+
@@ -16281,13 +15913,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -16649,7 +16279,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -20300,32 +19932,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -26517,24 +26149,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
response to chemical stimulus
response to chemical substance
@@ -27031,8 +26646,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/geneontology/go-ontology/issues/21881
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
- biological condensate
cellular_component
+ biological condensate
GO:0043228
non-membrane-bounded organelle
@@ -28097,25 +27712,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
+ https://github.com/geneontology/go-ontology/issues/25943
Wikipedia:Organogenesis
development of an organ
organogenesis
@@ -28625,6 +28224,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
+ tissue remodelling
biological_process
GO:0048771
@@ -29387,9 +28987,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
+ https://github.com/geneontology/go-ontology/issues/24200
establishment of localisation
biological_process
GO:0051234
+
@@ -30437,24 +30039,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
mah
2010-03-08T03:32:18Z
@@ -31238,25 +30823,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -31270,12 +30836,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
uptake
biological_process
@@ -31713,14 +31273,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
+ https://github.com/geneontology/go-ontology/issues/24200
kmv
2019-08-12T18:01:37Z
cellular_component
GO:0110165
+
cellular anatomical entity
@@ -32006,25 +31567,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
@@ -33274,9 +32818,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
- trait
quality
PATO:0000001
quality
@@ -33287,12 +32829,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
PATOC:GVG
-
-
-
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
- PATOC:GVG
-
@@ -33388,28 +32924,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- quality
- PATO:0000125
-
-
-
- For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
- mass
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- PATOC:GVG
-
-
-
-
@@ -33623,7 +33137,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
- multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
@@ -34479,27 +33992,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
-
- 2014-12-12T08:41:11Z
- quality
- PATO:0010000
- What counts as maximally connected may be relative to some specification of granularity.
- maximally connected
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
- GOC:dos
-
-
-
-
@@ -38163,7 +37655,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38845,7 +38336,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -38881,14 +38372,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
gastrula stage
-
+
-
+
BILS
@@ -39109,7 +38600,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39182,7 +38673,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -39195,7 +38686,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -39320,15 +38811,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -39370,34 +38861,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
-
+
Bgee:AN
@@ -39701,7 +39192,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39743,14 +39234,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -40980,7 +40471,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -41018,14 +40509,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -41078,7 +40569,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -41115,14 +40606,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -41167,7 +40658,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -41212,7 +40703,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -41225,7 +40716,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -41432,7 +40923,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41509,14 +41000,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb
-
+
-
+
MA
@@ -42177,7 +41668,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -42230,14 +41721,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -42325,7 +41816,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -42372,7 +41863,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
-
+
@@ -42386,7 +41877,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -42880,7 +42371,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Skeletal element that is composed of bone tissue.
@@ -42930,14 +42421,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -43048,7 +42539,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -43088,14 +42579,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -43372,8 +42863,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -43386,7 +42877,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -43443,34 +42934,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
-
+
-
+
-
+
-
+
AEO
-
+
EHDAA2
-
+
GO:0072360
@@ -44193,7 +43684,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -44227,14 +43718,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
-
+
-
+
check ctenophore
@@ -44363,7 +43854,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -44404,14 +43895,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
coelemic cavity lumen
-
+
-
+
definitional
@@ -44519,9 +44010,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
@@ -44576,15 +44067,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -44603,19 +44094,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -44700,8 +44191,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -44747,11 +44238,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -44764,13 +44255,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
GOTAX:0000352
-
+
ZFA
@@ -44883,12 +44374,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -44928,66 +44419,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -45175,7 +44666,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -45233,14 +44724,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
-
+
-
+
FMA
MA
@@ -45511,14 +45002,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -45561,24 +45052,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -45949,7 +45440,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -45974,14 +45465,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -46211,9 +45702,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -46245,34 +45736,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -46337,7 +45828,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -46366,7 +45857,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -46379,7 +45870,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -46451,7 +45942,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -46495,7 +45986,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -46508,7 +45999,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
VHOG
@@ -46592,15 +46083,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
-
+
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
@@ -46620,15 +46111,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
heart primordium
-
+
-
+
-
+
@@ -46641,19 +46132,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
ZFA
-
+
ZFA
-
+
XAO
@@ -46708,8 +46199,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -46736,11 +46227,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -46759,13 +46250,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
VHOG:0000680
-
+
ZFA
@@ -47031,7 +46522,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -47047,14 +46538,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -47373,8 +46864,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
@@ -47387,24 +46878,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004140
primary heart field
-
+
-
+
-
+
GO:0003128
-
+
https://orcid.org/0000-0003-3308-6245
@@ -47463,7 +46954,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
@@ -47483,14 +46974,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
heart tube
-
+
-
+
ZFA-modified
@@ -48107,7 +47598,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
@@ -48121,7 +47612,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
-
+
@@ -48134,7 +47625,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
2012-08-14
VSAO:0000015
VSAO
@@ -48173,7 +47664,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -48189,14 +47680,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal element
-
+
-
+
VSAO
@@ -48241,7 +47732,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -48280,14 +47771,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -49045,7 +48536,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -49061,14 +48552,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -49179,7 +48670,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
@@ -49197,14 +48688,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
primitive heart tube
-
+
-
+
ZFA
@@ -49372,7 +48863,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -49382,7 +48873,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -49401,7 +48892,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO-modified-relation
@@ -49506,7 +48997,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -49521,7 +49012,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochordal plate
-
+
@@ -49534,7 +49025,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
@@ -49571,7 +49062,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -49588,14 +49079,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -50338,7 +49829,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -50353,14 +49844,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -50450,7 +49941,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50467,14 +49958,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -50573,7 +50064,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50599,7 +50090,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive paraxial mesoderm
-
+
@@ -50615,7 +50106,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -50691,7 +50182,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -50699,7 +50190,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -50712,7 +50203,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -50809,7 +50300,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Anatomical system that consists of all blood and lymph vessels.
consider merging with vasculature
The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
@@ -50826,14 +50317,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
vascular system
-
+
-
+
MA
@@ -50966,7 +50457,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50983,14 +50474,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -51046,7 +50537,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -51054,14 +50545,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -51083,7 +50574,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EFO:0003704
TAO:0005041
ZFA:0005041
@@ -51093,14 +50584,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
anterior lateral plate mesoderm
-
+
-
+
ZFA
@@ -51234,7 +50725,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -51254,14 +50745,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0010210
blood clot
-
+
-
+
BTO
@@ -51383,8 +50874,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -51397,11 +50888,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
subdivision of skeleton
-
+
-
+
@@ -51414,13 +50905,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
UBERONREF:0000003
-
+
VSAO
@@ -51497,7 +50988,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
axial skeletal system
FMA:302077
@@ -51507,7 +50998,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
postcranial axial skeletal system
http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton
-
+
@@ -51520,7 +51011,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
cjm
@@ -51785,7 +51276,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -51807,7 +51298,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0012429
hematopoietic tissue
-
+
@@ -51820,7 +51311,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
defitional
@@ -52390,7 +51881,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -52413,7 +51904,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0016887
entire extraembryonic component
-
+
@@ -52426,7 +51917,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -52862,27 +52353,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
///////////////////////////////////////////////////////////////////////////////////////
-->
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
@@ -52949,27 +52419,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Should belong in BFO, but lives in caro for now.
-
-
-
-
-
@@ -53000,16 +52449,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
@@ -53999,5 +53438,5 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase
-
+
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.tsv b/src/ontology/subsets/blood_and_immune_upper_slim.tsv
index ad1a82d10..6f047699e 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.tsv
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.tsv
@@ -1,405 +1,395 @@
?x ?label
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1038
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1051
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1065
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1081
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1099
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1106
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1112
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1124
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1134
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1142
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid118
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1189
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1195
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid121
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1214
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1233
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1243
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1253
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1260
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1273
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1296
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1303
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1311
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1328
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1338
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1359
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1375
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1383
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1393
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1470
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1519
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1526
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1533
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1539
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1558
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1565
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1584
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1597
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1617
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1624
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1630
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1671
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1686
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1698
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1707
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1718
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1746
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1753
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1760
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1766
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1772
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1779
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1787
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1794
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1801
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1807
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1813
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1819
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1826
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1833
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1840
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1883
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1889
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1898
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1904
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1910
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1916
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1922
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1929
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1937
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1943
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1948
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1956
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1969
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1976
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1983
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1990
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1998
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2007
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2026
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2037
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2051
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2064
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2070
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2077
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2083
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2089
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2095
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2103
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2111
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2122
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2130
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2136
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2148
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2154
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2168
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2174
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2180
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2186
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2192
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2198
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2204
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2210
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2216
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2222
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2228
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2234
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2240
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2246
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2252
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2258
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2264
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2270
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2276
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2284
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2290
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2298
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2386
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2400
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2415
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2431
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2447
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2460
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2470
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2476
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2482
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2488
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2496
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2517
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2528
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2539
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2549
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2559
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2568
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2576
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2589
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2600
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2606
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2616
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2624
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2630
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2636
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2642
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2652
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2661
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2668
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2676
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2684
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2690
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2697
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2708
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2714
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2723
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2730
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2740
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2746
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2752
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2758
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2774
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2780
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2786
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2792
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2797
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2804
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2813
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2820
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2832
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2842
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2848
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2859
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2875
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2885
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2894
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2901
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2916
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2924
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2939
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2945
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2951
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2958
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2968
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2986
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2996
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3003
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3009
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3015
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3020
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3025
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3031
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3037
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3063
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3073
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3080
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3086
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3093
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3101
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3107
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3113
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3119
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3126
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3134
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3140
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3146
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3152
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3158
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3164
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3170
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3176
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3188
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3195
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3202
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3210
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3221
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3227
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3233
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3239
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3245
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3251
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3258
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3264
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3270
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3280
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3288
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3294
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid33
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3305
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid331
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3311
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3317
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3323
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3334
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3343
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3349
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3356
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3362
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3368
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3374
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3382
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid339
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3392
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3399
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3404
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3416
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3423
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3429
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3445
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid345
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3458
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3466
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3473
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3479
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3491
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3498
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3504
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3516
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3522
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3540
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3546
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3552
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3559
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3569
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3575
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3585
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid359
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3591
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3601
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3607
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3614
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3620
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3625
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3632
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3641
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3651
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3659
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid366
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3665
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3671
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3677
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3688
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3694
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3703
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3772
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3815
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3821
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4057
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4064
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4073
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4084
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4095
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4168
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid417
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid42
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4204
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4246
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4253
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4262
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4331
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4343
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4356
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4365
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid437
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4426
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4455
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4471
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid454
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4545
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4564
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4596
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4607
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid464
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4645
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4660
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4675
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4719
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid480
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4815
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4842
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid488
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4892
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid494
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4991
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5003
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid501
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5019
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5024
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5038
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5045
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5087
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid509
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5103
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5110
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5124
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5155
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5169
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5193
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5225
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5233
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5241
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5249
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5260
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5275
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5317
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5327
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5337
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5342
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5351
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5362
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5372
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5398
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5407
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid541
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5417
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5432
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5441
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5452
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5471
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5513
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5523
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5537
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5544
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5575
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5587
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5592
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5627
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5635
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5651
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5659
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5692
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5696
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5700
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5702
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5705
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5709
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid571
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5713
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5717
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5721
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid59
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid626
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid633
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid645
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid657
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid663
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid669
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid675
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid698
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid704
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid716
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid723
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid729
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid738
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid746
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid779
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid788
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid803
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid856
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid873
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid893
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid908
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid963
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1006
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1019
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1033
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1049
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1067
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1074
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1080
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1092
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1102
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1110
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid112
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid115
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1157
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1163
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1182
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1201
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1211
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1221
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1228
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1241
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1264
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1271
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1279
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1296
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1306
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1327
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1343
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1351
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1361
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1438
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1487
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1494
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1501
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1507
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1526
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1533
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1552
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1565
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1585
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1592
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1598
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1639
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1654
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1666
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1675
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1686
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1714
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1721
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1728
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1734
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1740
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1747
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1755
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1762
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1769
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1775
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1781
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1787
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1794
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1801
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1808
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1851
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1857
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1866
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1872
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1878
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1884
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1890
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1897
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1905
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1911
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1916
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1924
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1937
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1944
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1951
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1958
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1966
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1975
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1994
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2005
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2019
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2032
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2038
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2045
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2051
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2057
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2063
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2071
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2079
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2090
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2098
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2104
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2116
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2122
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2136
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2142
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2148
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2154
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2160
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2166
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2172
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2178
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2184
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2190
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2196
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2202
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2208
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2214
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2220
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2226
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2232
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2238
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2244
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2252
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2258
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2266
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2354
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2368
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2383
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2399
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2415
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2428
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2438
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2444
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2450
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2456
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2464
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2485
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2496
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2507
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2517
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2527
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2536
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2544
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2557
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2568
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2574
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2584
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2592
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2598
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2604
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2610
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2620
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2629
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2636
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2644
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2652
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2658
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2665
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2676
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2682
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2691
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2698
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2708
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2714
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2720
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2726
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2742
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2748
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2754
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2760
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2765
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2772
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2781
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2788
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2800
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2810
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2816
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2827
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2843
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2853
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2862
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2869
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2884
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2892
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2907
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2913
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2921
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2931
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2949
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2959
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2966
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2972
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2978
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2983
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2988
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2994
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3000
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3026
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3036
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3043
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3049
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3056
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3064
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3070
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3076
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3082
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3089
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3098
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid31
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3104
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3110
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3116
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3122
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3128
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3134
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3146
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3153
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3160
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3168
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3179
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3185
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3191
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3197
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3203
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3209
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3216
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3222
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3228
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3238
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3246
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3252
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3263
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3269
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid327
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3275
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3281
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3292
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3301
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3307
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3314
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3320
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3326
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3332
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid334
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3340
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3350
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3357
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3362
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3374
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3381
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3398
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3411
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3419
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3426
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3432
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3444
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3451
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3457
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3469
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3484
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3490
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3496
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3503
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3513
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3519
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3529
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3535
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3545
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3551
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3558
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3564
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3569
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3576
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3590
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3598
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3604
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3610
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3616
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3627
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3633
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3642
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3709
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3752
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3758
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid385
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid39
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3993
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4000
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4009
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4020
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4031
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid405
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4104
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4140
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4182
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4189
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4198
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid422
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4267
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4279
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4292
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4301
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid432
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4362
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4391
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4407
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid448
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4481
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4500
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4532
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4543
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid456
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4581
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4596
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4611
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid462
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4655
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid469
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4751
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid477
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4778
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4828
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4927
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4939
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4955
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4960
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4974
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4981
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5023
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5039
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5046
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5060
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid509
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5091
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5105
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5129
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5161
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5169
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5177
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5185
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5196
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5211
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5253
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5263
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5273
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5278
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5287
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5298
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5308
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5334
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5343
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5353
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5368
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5377
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5388
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid539
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid54
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5407
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5449
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5459
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5473
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5480
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5511
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5523
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5528
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5563
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5571
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5587
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5595
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5628
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5630
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5633
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5637
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5641
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5645
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5649
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid594
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid601
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid613
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid625
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid631
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid637
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid643
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid666
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid672
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid684
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid691
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid697
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid706
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid714
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid747
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid756
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid771
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid824
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid841
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid861
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid876
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid931
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid962
"continuant"
"occurrent"
"independent continuant"
@@ -407,17 +397,6 @@ _:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
"specifically dependent continuant"
"material entity"
"immaterial entity"
- "anatomical entity"
- "connected anatomical structure"
- "material anatomical entity"
- "multicellular organism"
- "gross anatomical part"
- "organism"
- "multicellular anatomical structure"
- "cellular organism"
- "biological entity"
-
-
"cell"
"early embryonic cell (metazoa)"
"stem cell"
@@ -1036,7 +1015,6 @@ _:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
"qualitative"
"deviation (from_normal)"
"size"
- "mass"
"structure"
"maturity"
"branched"
@@ -1084,7 +1062,6 @@ _:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
"superelliptic"
"acidophilic"
"nucleated"
- "maximally connected"
"disconnected"
"polymeric"
"anatomical structure quality"
diff --git a/src/ontology/subsets/eye_upper_slim.json b/src/ontology/subsets/eye_upper_slim.json
index 7bc23a637..626805b20 100644
--- a/src/ontology/subsets/eye_upper_slim.json
+++ b/src/ontology/subsets/eye_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-09-21"
+ "val" : "2023-10-19"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-09-21/subsets/eye_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-10-19/subsets/eye_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -296,9 +296,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "occurs_in"
@@ -724,185 +721,6 @@
"val" : "in_dorsal_side_of"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "lbl" : "anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
- "xrefs" : [ "CAROC:Brownsville2014" ]
- },
- "comments" : [ "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "lbl" : "connected anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
- },
- "comments" : [ "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "lbl" : "material anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical entity that has mass."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "lbl" : "multicellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
- },
- "comments" : [ "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "lbl" : "gross anatomical part",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#plus" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "10.7.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "lbl" : "organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- },
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "organism or virus or viroid"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "Melissa Haendel"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "9/18/11"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "lbl" : "multicellular anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical structure that has more than one cell as a part."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "djs93"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "Sun Feb 27 10:53:00 GMT 2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "lbl" : "cellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An individual member of a clade of cellular organisms."
- },
- "comments" : [ "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. " ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "7.16.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "lbl" : "biological entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
- },
- "comments" : [ "Important for alignment with Darwin Core class \"Organism\"." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_33709",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A carboxylic acid containing one or more amino groups.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "Aminocarbonsaeure",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "Aminokarbonsaeure",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "Aminosaeure",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "amino acids",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_50860",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any molecular entity that contains carbon.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "organic compounds",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic entity",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic molecular entities",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000000",
"lbl" : "cell",
@@ -1040,7 +858,7 @@
"pred" : "hasExactSynonym",
"val" : "hemopoietic stem cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HSC"
}, {
@@ -1076,11 +894,11 @@
},
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BFU-E"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-E"
}, {
@@ -1141,17 +959,17 @@
"pred" : "hasExactSynonym",
"val" : "common myeloid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GEMM",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-S",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CMP",
"xrefs" : [ "ISBN:0878932437" ]
@@ -1336,7 +1154,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"
} ]
}
@@ -1529,7 +1347,7 @@
"xrefs" : [ "MESH:D009457" ]
},
"comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ],
- "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "neuroglial cell"
@@ -1545,6 +1363,10 @@
"val" : "FBbt:00005144"
}, {
"val" : "FMA:54536"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1655,15 +1477,15 @@
"val" : "marrow stromal cells",
"xrefs" : [ "PMID:11378515" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BMSC"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-F"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "MSC",
"xrefs" : [ "PMID:11378515" ]
@@ -1772,15 +1594,10 @@
"val" : "A cell that specializes in controlled release of one or more substances.",
"xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "BTO:0003659"
}, {
"val" : "FMA:86916"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1823,7 +1640,7 @@
"val" : "WBbt:0003675"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg"
} ]
}
@@ -1897,7 +1714,7 @@
"val" : "FMA:86740"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"
} ]
}
@@ -2302,7 +2119,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg"
} ]
}
@@ -2570,12 +2387,12 @@
"pred" : "hasExactSynonym",
"val" : "amacrine neuron"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "AC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "ACs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
@@ -2600,17 +2417,12 @@
"xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
},
"comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "angioblast"
}, {
"pred" : "hasExactSynonym",
"val" : "chondroplast"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -2822,12 +2634,12 @@
"pred" : "hasExactSynonym",
"val" : "ganglion cell of retina"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "RGC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "RGCs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
@@ -2858,12 +2670,12 @@
"pred" : "hasExactSynonym",
"val" : "horizontal cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "HCs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
@@ -2887,17 +2699,17 @@
},
"subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "BCs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "BPs",
"xrefs" : [ "GSE137537" ]
@@ -3323,7 +3135,6 @@
"val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.",
"xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "CALOHA:TS-2096"
}, {
@@ -3332,9 +3143,6 @@
"val" : "MESH:D003239"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- }, {
"pred" : "http://purl.org/dc/terms/contributor",
"val" : "https://orcid.org/0000-0003-1980-3228"
}, {
@@ -3584,12 +3392,7 @@
"definition" : {
"val" : "Any muscle cell in which the fibers are not organised into sarcomeres.",
"xrefs" : [ "GOC:DOS" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0008001",
@@ -3622,9 +3425,14 @@
"definition" : {
"val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
},
+ "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "mesenchyme cell"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -4078,20 +3886,6 @@
"val" : "cellular_component"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/GO_0001505",
- "lbl" : "regulation of neurotransmitter levels",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any process that modulates levels of neurotransmitter.",
- "xrefs" : [ "GOC:jl" ]
- },
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "biological_process"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/GO_0001508",
"lbl" : "action potential",
@@ -8039,7 +7833,7 @@
"pred" : "hasExactSynonym",
"val" : "non-membrane-enclosed organelle"
}, {
- "pred" : "hasNarrowSynonym",
+ "pred" : "hasRelatedSynonym",
"val" : "biological condensate"
} ],
"xrefs" : [ {
@@ -8530,6 +8324,9 @@
"val" : "Wikipedia:Organogenesis"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/25943"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -8971,13 +8768,16 @@
"val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.",
"xrefs" : [ "GOC:ai", "GOC:dos" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "establishment of localisation",
"xrefs" : [ "GOC:mah" ]
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -10214,8 +10014,11 @@
"val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
"xrefs" : [ "GOC:kmv" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
"val" : "kmv"
}, {
@@ -10594,7 +10397,7 @@
"val" : "http://purl.obolibrary.org/obo/IAO_0000122"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
- "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "PERSON:Daniel Schober"
@@ -11800,6 +11603,28 @@
"val" : "https://orcid.org/0000-0002-8688-6599"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/OMO_0003000",
+ "lbl" : "abbreviation",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A synonym type for describing abbreviations or initalisms"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/information-artifact-ontology/ontology-metadata/issues/122"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-4423-4370"
+ }, {
+ "pred" : "http://purl.org/dc/terms/created",
+ "val" : "2023-03-03"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/OMO_0003004",
"lbl" : "plural form",
@@ -11828,13 +11653,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.",
+ "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities",
"xrefs" : [ "PATOC:GVG" ]
},
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "trait"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
"val" : "PATO:0000072"
@@ -11922,22 +11743,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "lbl" : "mass",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.",
- "xrefs" : [ "PATOC:GVG" ]
- },
- "comments" : [ "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/pato#attribute_slim", "http://purl.obolibrary.org/obo/pato#relational_slim", "http://purl.obolibrary.org/obo/pato#scalar_slim" ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0000136",
"lbl" : "closure",
@@ -12247,9 +12052,6 @@
}, {
"pred" : "hasExactSynonym",
"val" : "multiply inhering quality of a physical entity"
- }, {
- "pred" : "hasExactSynonym",
- "val" : "multiply inhering quality of a physical entity "
}, {
"pred" : "hasExactSynonym",
"val" : "quality of a continuant"
@@ -12994,27 +12796,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "lbl" : "maximally connected",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.",
- "xrefs" : [ "GOC:dos" ]
- },
- "comments" : [ "What counts as maximally connected may be relative to some specification of granularity." ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-7073-9172"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
- "val" : "2014-12-12T08:41:11Z"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0010001",
"lbl" : "disconnected",
@@ -14643,7 +14424,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002000",
- "lbl" : "boundary_of",
+ "lbl" : "2D boundary of",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -14680,7 +14461,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002002",
- "lbl" : "has_boundary",
+ "lbl" : "has 2D boundary",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -15079,12 +14860,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a neuron and a material anatomical entity that its soma is part of."
},
- "xrefs" : [ {
- "val" : "RO:0002100"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15094,15 +14871,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some (\n and some ?Y)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15113,9 +14884,6 @@
"definition" : {
"val" : "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"
},
- "xrefs" : [ {
- "val" : "RO:0002101"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15134,9 +14902,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15173,8 +14938,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between an anatomical structure and a neuron that chemically synapses to it.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "
},
"xrefs" : [ {
"val" : "RO:0002103"
@@ -15191,18 +14955,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that has_part some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -15253,10 +15011,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "
},
- "comments" : [ "Relation between a neuron and the structure in which its dendrite receives synapses." ],
- "xrefs" : [ {
- "val" : "RO:0002110"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15269,9 +15023,6 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "synapsed in"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))"
@@ -15281,9 +15032,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15294,9 +15042,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."
},
- "xrefs" : [ {
- "val" : "RO:0002113"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15306,18 +15051,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15326,13 +15065,9 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that it chemically synapses to.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n "
},
"comments" : [ "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ],
- "xrefs" : [ {
- "val" : "RO:0002120"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15345,18 +15080,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15365,13 +15094,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
},
- "comments" : [ "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)" ],
- "xrefs" : [ {
- "val" : "RO:0002130"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15384,18 +15108,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15464,8 +15182,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."
},
"xrefs" : [ {
"val" : "RO:0002134"
@@ -15479,18 +15196,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that ( some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -16115,9 +15826,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "regulates"
@@ -16150,9 +15858,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "negatively_regulates"
@@ -16185,9 +15890,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "positively_regulates"
@@ -19853,6 +19555,47 @@
"val" : "https://orcid.org/0000-0003-4639-4431"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "lbl" : "has small molecule regulator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:27:26Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "lbl" : "has small molecule activator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
+ },
+ "xrefs" : [ {
+ "val" : "RO:0012001"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:28:37Z"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
+ "val" : "external"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
+ "val" : "has_small_molecule_activator"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012003",
"lbl" : "acts on population of",
@@ -19879,6 +19622,41 @@
"val" : "acts_on_population_of"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "lbl" : "is small molecule regulator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:17Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "lbl" : "is small molecule activator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:26Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_small_molecule_activator_of"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012008",
"lbl" : "results in fusion of",
@@ -39468,19 +39246,6 @@
"val" : "uberon"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/cl#abbreviation",
- "lbl" : "abbreviation",
- "type" : "PROPERTY",
- "meta" : {
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/elements/1.1/date",
- "val" : "2022-03-29T15:09:49Z"
- }, {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-1773-2692"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim",
"lbl" : "blood_and_immune_upper_slim",
@@ -40043,25 +39808,6 @@
"val" : "seeAlso"
} ]
}
- }, {
- "id" : "http://xmlns.com/foaf/0.1/depicted_by",
- "lbl" : "depicted by",
- "type" : "PROPERTY",
- "meta" : {
- "xrefs" : [ {
- "val" : "http://xmlns.com/foaf/0.1/depicted_by"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "uberon"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag",
- "val" : "true"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
- "val" : "depicted_by"
- } ]
- }
} ],
"edges" : [ {
"sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
@@ -40083,70 +39829,6 @@
"sub" : "http://purl.obolibrary.org/obo/BFO_0000141",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0030000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0010000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000125"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000012"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001008"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001993"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001010"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000000",
"pred" : "is_a",
@@ -42011,10 +41693,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0000792",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0000785"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0001505",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002160",
- "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0001508",
"pred" : "is_a",
@@ -42357,10 +42035,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0006865",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0006810"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0006865",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0006915",
"pred" : "is_a",
@@ -42453,10 +42127,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0007268",
"pred" : "http://purl.obolibrary.org/obo/RO_0000057",
"obj" : "http://purl.obolibrary.org/obo/GO_0045202"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0007269",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/GO_0001505"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0007269",
"pred" : "is_a",
@@ -43405,10 +43075,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0048513",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0048856"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0048513",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002296",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0048598",
"pred" : "is_a",
@@ -43773,10 +43439,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0071704",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0008152"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0071704",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004007",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0071826",
"pred" : "is_a",
@@ -44033,10 +43695,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0099643",
"pred" : "http://purl.obolibrary.org/obo/RO_0002160",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0110165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0110165",
"pred" : "is_a",
@@ -44109,10 +43767,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_1901576",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0071704"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_1901576",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004008",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_1903047",
"pred" : "is_a",
@@ -44289,10 +43943,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0000117",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001018"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0000136",
"pred" : "is_a",
@@ -44517,10 +44167,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0002505",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0001404"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000141"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0010001",
"pred" : "is_a",
@@ -44827,10 +44473,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002497",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
"pred" : "is_a",
@@ -52534,10 +52176,30 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0011002",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012000"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012003",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002596"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002598"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012008",
"pred" : "subPropertyOf",
@@ -52842,36 +52504,20 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0003000",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012005"
}, {
"sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to"
} ],
"logicalDefinitionAxioms" : [ {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010000"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0000125"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001993"
- } ]
- }, {
"definedClassId" : "http://purl.obolibrary.org/obo/CL_0000005",
"genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ],
"restrictions" : [ {
@@ -53716,13 +53362,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0012003",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000763"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006865",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33709"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0006921",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ],
@@ -54087,13 +53726,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000000"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048513",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
- "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0048729",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ],
@@ -54227,13 +53859,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002588",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0043226"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071704",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0071826",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ],
@@ -54379,13 +54004,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901576",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_1903047",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009987" ],
@@ -55496,10 +55114,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0000278",
"pred" : "http://purl.obolibrary.org/obo/RO_0002162",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0001505",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002162",
- "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0005581",
"pred" : "http://purl.obolibrary.org/obo/RO_0002162",
@@ -55602,7 +55216,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002002",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040", "http://purl.obolibrary.org/obo/CARO_0000003" ],
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
diff --git a/src/ontology/subsets/eye_upper_slim.obo b/src/ontology/subsets/eye_upper_slim.obo
index ebd5d3647..22f785aa9 100644
--- a/src/ontology/subsets/eye_upper_slim.obo
+++ b/src/ontology/subsets/eye_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-09-21/subsets/eye_upper_slim.owl
+data-version: cl/releases/2023-10-19/subsets/eye_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,13 +82,12 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/eye_upper_slim
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -147,109 +138,6 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:33709
-namespace: chebi_ontology
-def: "A carboxylic acid containing one or more amino groups." [ANON:ANON]
-synonym: "amino acids" RELATED [ChEBI:]
-synonym: "Aminocarbonsaeure" RELATED [ChEBI:]
-synonym: "Aminokarbonsaeure" RELATED [ChEBI:]
-synonym: "Aminosaeure" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -346,7 +234,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -392,10 +280,10 @@ id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
-synonym: "BFU-E" RELATED abbreviation []
+synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
-synonym: "CFU-E" RELATED abbreviation []
+synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
@@ -424,9 +312,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -522,7 +410,7 @@ xref: WBbt:0003672
is_a: CL:0000000 ! cell
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000071
@@ -654,6 +542,7 @@ name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: general_cell_types_upper_slim
+subset: human_reference_atlas
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
@@ -661,6 +550,7 @@ xref: CALOHA:TS-0415
xref: FBbt:00005144
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000126
@@ -713,9 +603,9 @@ id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -723,7 +613,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -771,14 +661,12 @@ is_a: CL:0000147 ! pigment cell
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000183
@@ -801,7 +689,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000192
@@ -845,7 +733,7 @@ is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -1124,7 +1012,7 @@ is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000541
@@ -1359,8 +1247,8 @@ name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "AC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "ACs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "AC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "ACs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FMA:67766
@@ -1376,7 +1264,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -1387,7 +1274,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -1517,8 +1403,8 @@ subset: eye_upper_slim
subset: human_reference_atlas
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
-synonym: "RGC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "RGCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
@@ -1532,8 +1418,8 @@ name: retina horizontal cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "HC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "HCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "HC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "HCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
is_a: CL:0000099 ! interneuron
@@ -1546,9 +1432,9 @@ name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "BC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "BCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "BPs" RELATED abbreviation [GSE137537]
+synonym: "BC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "BCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
+synonym: "BPs" RELATED OMO:0003004 [GSE137537]
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
@@ -1850,7 +1736,6 @@ creation_date: 2010-09-15T01:34:57Z
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -1859,7 +1744,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -2011,9 +1895,7 @@ creation_date: 2012-06-27T08:27:35Z
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
-subset: human_reference_atlas
is_a: CL:0000187 ! muscle cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0008001
@@ -2035,10 +1917,12 @@ relationship: part_of UBERON:8600004 ! visceral muscle tissue
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0008028
@@ -2284,14 +2168,6 @@ xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI
-[Term]
-id: GO:0001505
-name: regulation of neurotransmitter levels
-namespace: biological_process
-def: "Any process that modulates levels of neurotransmitter." [GOC:jl]
-relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
-relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-
[Term]
id: GO:0001508
name: action potential
@@ -2892,9 +2768,6 @@ def: "The directed movement of amino acids, organic acids containing one or more
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006810 ! transport
-intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:33709
-relationship: has_primary_input CHEBI:33709
[Term]
id: GO:0006915
@@ -3081,7 +2954,6 @@ comment: A neurotransmitter is any of a group of substances that are released on
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
@@ -4453,7 +4325,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -4729,9 +4601,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048598
@@ -4979,12 +4849,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051239
@@ -5325,9 +5197,6 @@ synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:50860
-relationship: has_primary_input_or_output CHEBI:50860
created_by: mah
creation_date: 2010-03-08T03:32:18Z
@@ -5663,10 +5532,11 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -5770,9 +5640,6 @@ synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:50860
-relationship: has_primary_output CHEBI:50860
created_by: pr
creation_date: 2012-11-05T11:04:40Z
@@ -6158,8 +6025,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -6205,17 +6070,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000136
name: closure
@@ -6371,7 +6225,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -6753,16 +6606,6 @@ is_a: PATO:0001404 ! nucleate quality
relationship: dc-contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -7351,7 +7194,7 @@ intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
[Term]
id: UBERON:0000025
@@ -7443,8 +7286,8 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: has_part UBERON:0001136 ! mesothelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0000060 ! anatomical wall
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: UBPROP:0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005425", ontology="TAO", source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000001 "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" xsd:string {source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." xsd:string {external_ontology="FMA"}
@@ -7547,7 +7390,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological_process
@@ -7726,7 +7568,7 @@ xref: Wikipedia:External_ectoderm
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0000924 {source="EHDAA2"} ! ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
property_value: editor_note "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" xsd:string
property_value: RO:0002171 UBERON:0002346
property_value: UBPROP:0000011 "(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis" xsd:string
@@ -7890,7 +7732,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -8058,7 +7900,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -8151,7 +7993,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -8611,7 +8453,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -8642,7 +8484,7 @@ is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: has_part CL:0000076 ! squamous epithelial cell
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"}
[Term]
@@ -8787,7 +8629,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -8862,7 +8704,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -8902,8 +8744,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -8949,7 +8791,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -8988,7 +8830,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -9209,7 +9051,7 @@ is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: has_quality PATO:0002124 ! laminar
relationship: has_quality PATO:0002124 ! laminar
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
property_value: editor_note "TODO - merge with cell layer?" xsd:string
property_value: UBPROP:0000007 "laminar" xsd:string
@@ -9261,7 +9103,7 @@ intersection_of: extends_fibers_into UBERON:0001908 ! optic tract
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II
relationship: extends_fibers_into UBERON:0001908 ! optic tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The point at which fibers of the optic nerves cross.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010622", ontology="AAO", source="AAO:DSM"}
property_value: UBPROP:0000003 "The chiasm has been studied in great detail in some animals, while in others relatively little or nothing is known. Although there are some gross architectural features that are conserved within some animals, such as birds and fish, the general picture is one of diversity. This review will attempt to consider the key features of such diversity of chiasmatic organisation in vertebrates and the mechanisms that sculpt them from the limited literature that is available. However, as so much research has been undertaken on the structure and development of the chiasm in laboratory animals, any review must consider the information that has been gleaned from them and hope that future studies will determine whether the features revealed in these animals, and the underlying mechanisms that generate them, have a common vertebrate plan.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000190", ontology="VHOG", source="DOI:10.1016/j.preteyeres.2005.04.005 Jeffery G, Erskine L, Variations in the architecture and development of the vertebrate optic chiasm. Progress in retinal and eye research (2005)", source="http://bgee.unil.ch/"}
@@ -9313,7 +9155,7 @@ relationship: part_of UBERON:0001801 {source="MA"} ! anterior segment of eyeball
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: part_of UBERON:0012430 {source="FMA-isa"} ! tunica fibrosa of eyeball
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000007 "corneal" xsd:string
property_value: UBPROP:0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" xsd:string
@@ -9418,7 +9260,7 @@ relationship: never_in_taxon NCBITaxon:6656
relationship: part_of UBERON:0001802 ! posterior segment of eyeball
relationship: part_of UBERON:0019207 ! chorioretinal region
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000152", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "retinal" xsd:string
@@ -9554,7 +9396,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -9636,7 +9478,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073
relationship: never_in_taxon NCBITaxon:6157
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -9677,7 +9519,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -9733,8 +9575,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -9877,7 +9719,7 @@ is_a: UBERON:0015203 ! non-connected functional system
relationship: capable_of_part_of GO:0007600 ! sensory perception
relationship: overlaps UBERON:0001016 ! nervous system
relationship: part_of UBERON:0004456 ! entire sense organ system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string
@@ -9946,7 +9788,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -10026,7 +9868,7 @@ intersection_of: has_part CL:0000192 ! smooth muscle cell
relationship: composed_primarily_of CL:0000192 ! smooth muscle cell
relationship: has_part CL:0000192 ! smooth muscle cell
relationship: has_part GO:0071953 ! elastic fiber
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI
property_value: UBPROP:0000001 "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005274", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010244", ontology="AAO", source="AAO:CAM"}
property_value: UBPROP:0000003 "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001246", ontology="VHOG", source="DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011)", source="http://bgee.unil.ch/"}
@@ -10062,7 +9904,7 @@ intersection_of: develops_from UBERON:0000926 ! mesoderm
intersection_of: part_of UBERON:0000042 ! serous membrane
relationship: composed_primarily_of CL:0000077 {source="FMA"} ! mesothelial cell
relationship: part_of UBERON:0000042 ! serous membrane
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI
[Term]
id: UBERON:0001137
@@ -10087,7 +9929,7 @@ xref: UMLS:C0004600 {source="ncithesaurus:Back"}
xref: Wikipedia:Dorsum_(anatomy)
is_a: UBERON:0000475 ! organism subdivision
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI
property_value: UBPROP:0000007 "dorsal" xsd:string
property_value: UBPROP:0000008 "In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body" xsd:string
@@ -10177,7 +10019,7 @@ xref: Wikipedia:Face
is_a: UBERON:0001444 ! subdivision of head
relationship: contributes_to_morphology_of UBERON:0000033 ! head
relationship: has_part UBERON:0000165 ! mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face." xsd:string {source="FMA:24728"}
property_value: UBPROP:0000001 "The area that extends from the median ocellus to the oral foramen[HAO]." xsd:string {source="HAO:0000316", source="http://api.hymao.org/api/ref/67791", taxon="NCBITaxon:7399"}
property_value: UBPROP:0000007 "facial" xsd:string
@@ -10253,7 +10095,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle
relationship: part_of UBERON:0001775 {source="FMA"} ! ciliary body
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI
[Term]
id: UBERON:0001630
@@ -10319,7 +10161,7 @@ relationship: capable_of GO:0060082 ! eye blink reflex
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 {source="multiple"} ! camera-type eye
relationship: protects UBERON:0010409 ! ocular surface region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI
property_value: UBPROP:0000007 "blepharic" xsd:string
property_value: UBPROP:0000007 "palpebral" xsd:string
property_value: UBPROP:0000008 "In humans the upper and lower eyelid consists of the following layers, starting anteriorly: (1) skin, (2) a layer of subcutaneous connective tissue, (3) a layer of striated muscle fibres of the orbicularis muscle, (4) a layer of submuscular connective tissue, (5) a fibrous layer, including the tarsal plates, (6) a layer of smooth muscle, (7) the palpebral conjunctiva." xsd:string
@@ -10356,7 +10198,7 @@ xref: Wikipedia:Anterior_chamber_of_eyeball
is_a: UBERON:0006311 {source="FMA"} ! chamber of eyeball
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001431", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/anterior+chamber"}
property_value: UBPROP:0000012 "space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball" xsd:string {external_ontology="EHDAA2"}
@@ -10391,7 +10233,7 @@ relationship: has_part UBERON:0001775 ! ciliary body
relationship: has_part UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
relationship: present_in_taxon NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI
property_value: editor_note "TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus" xsd:string
property_value: UBPROP:0000007 "uveal" xsd:string
@@ -10484,7 +10326,7 @@ relationship: bounding_layer_of UBERON:0000964 ! cornea
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002187", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"}
property_value: UBPROP:0000008 "In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei" xsd:string
property_value: UBPROP:0000008 "In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" xsd:string
@@ -10523,7 +10365,7 @@ relationship: has_part CL:0000347 {source="ZFA"} ! scleral cell
relationship: has_quality PATO:0000963 ! opaque
relationship: part_of UBERON:0012430 {source="FMA"} ! tunica fibrosa of eyeball
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]." xsd:string {source="Wikipedia:Sclera"}
property_value: UBPROP:0000001 "The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001274", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sclera"}
property_value: UBPROP:0000007 "scleral" xsd:string
@@ -10569,7 +10411,7 @@ relationship: has_part UBERON:0001605 ! ciliary muscle
relationship: has_part UBERON:0010427 ! ciliary processes
relationship: part_of UBERON:0011892 ! anterior uvea
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000102", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
[Term]
@@ -10614,7 +10456,7 @@ relationship: overlaps UBERON:0001802 {source="Wikipedia"} ! posterior segment o
relationship: part_of UBERON:0001768 {source="MA"} ! uvea
relationship: part_of UBERON:0019207 ! chorioretinal region
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: editor_note "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" xsd:string
property_value: UBPROP:0000007 "choroidal" xsd:string
property_value: UBPROP:0000012 "MP treats posterior uvea and optic choroid as distinct" xsd:string {external_ontology="MP"}
@@ -10653,7 +10495,7 @@ relationship: adjacent_to UBERON:0004370 ! anterior limiting lamina of cornea
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0007213 {inferred_by="cjm", source="ISBN:0781772214", source="Wikipedia"} ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0000964 ! cornea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"}
property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"}
property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"}
@@ -10763,7 +10605,7 @@ relationship: adjacent_to UBERON:0003902 ! retinal neural layer
relationship: has_part GO:0048770 ! pigment granule
relationship: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000144", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The monolayer of pigmented epithelium covering the neural retina.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011096", ontology="AAO", source="ZFA:0000144"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000536", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -10796,7 +10638,7 @@ is_a: UBERON:0001781 ! layer of retina
relationship: adjacent_to UBERON:0001788 ! outer limiting layer of retina
relationship: has_part CL:0000287 {source="ZFA"} ! eye photoreceptor cell
relationship: part_of UBERON:0003902 ! retinal neural layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "we follow MA and ZFA in subdividing this into inner and outer segments" xsd:string {external_ontology="MA"}
@@ -10994,7 +10836,7 @@ relationship: composed_primarily_of CL:0000740 ! retinal ganglion cell
relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer
relationship: part_of UBERON:0003902 {source="FMA"} ! retinal neural layer
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]." xsd:string {source="Wikipedia:Ganglion_cell_layer"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030]" xsd:string {external_ontology="NIF"}
@@ -11114,7 +10956,7 @@ relationship: has_part GO:0030425 ! dendrite
relationship: overlaps CL:0000740 ! retinal ganglion cell
relationship: overlaps CL:0000748 ! retinal bipolar neuron
relationship: part_of UBERON:0003902 ! retinal neural layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells[GO][GO:0010842]." xsd:string {source="GO:0010842"}
property_value: UBPROP:0000001 "The layer within the retina where the bipolar cells synapse with the dendrites of the ganglion cells.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001329", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001168", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -11149,7 +10991,7 @@ is_a: UBERON:0006312 ! ocular refractive media
is_a: UBERON:0006314 ! bodily fluid
relationship: contributes_to_morphology_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 {notes="FMA def states A and P", notes="located_in in EHDAA2", source="VHOG"} ! anterior chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aqueous+humour"}
property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." xsd:string {external_ontology="FMA"}
@@ -11187,7 +11029,7 @@ is_a: UBERON:0006312 ! ocular refractive media
relationship: has_quality PATO:0000964 ! transparent
relationship: located_in UBERON:0005606 ! hyaloid cavity
relationship: part_of UBERON:0001798 ! vitreous body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
[Term]
id: UBERON:0001798
@@ -11209,7 +11051,7 @@ is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue
relationship: composed_primarily_of UBERON:0001797 ! vitreous humor
relationship: has_developmental_contribution_from UBERON:0002346 {notes="neural ectoderm of optic cup", source="ISBN:0781772214"} ! neurectoderm
relationship: part_of UBERON:0001799 ! vitreous chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: editor_note "distinciton between body and humor requires more work. These may be merged in future. Note that FMA includes the hyaloid canal as part of the vitreous body" xsd:string
[Term]
@@ -11266,7 +11108,7 @@ disjoint_from: UBERON:0001802 {source="lexical"} ! posterior segment of eyeball
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: in_anterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye
relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001802 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
[Term]
@@ -11295,7 +11137,7 @@ is_a: UBERON:0000063 ! organ subunit
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: in_posterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye
relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
[Term]
id: UBERON:0001811
@@ -11333,7 +11175,7 @@ relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external
relationship: part_of UBERON:0005908 {source="cjm"} ! conjunctival sac
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
property_value: UBPROP:0000007 "conjunctival" xsd:string
[Term]
@@ -11381,7 +11223,7 @@ relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: develops_from UBERON:0003080 ! anterior neural tube
relationship: immediate_transformation_of UBERON:0006240 {evidence="definitional"} ! future forebrain
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: UBPROP:0000001 "Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010147", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000002 "relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO"}
@@ -11437,7 +11279,7 @@ relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: has_developmental_contribution_from UBERON:0003849 {evidence="definitional"} ! mesencephalic neural crest
relationship: immediate_transformation_of UBERON:0009616 {source="Bgee:AN"} ! presumptive midbrain
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI
property_value: editor_note "developmental relationships need revised" xsd:string
property_value: RO:0002171 UBERON:0001894 {exceptions="ZFA", exceptions_url="https://github.com/obophenotype/uberon/issues/378", source="ABA", status="pending"}
property_value: RO:0002171 UBERON:0002028 {exceptions="ZFA", source="ABA", status="pending"}
@@ -11508,7 +11350,7 @@ relationship: has_developmental_contribution_from UBERON:0003851 {evidence="defi
relationship: immediate_transformation_of UBERON:0006222 {evidence="definitional"} ! future diencephalon
relationship: part_of UBERON:0001890 ! forebrain
relationship: present_in_taxon NCBITaxon:7762 {notes="not well differentiated from the cerebrum. (Ariens, p. 868)", source="PMID:8932866"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0002028 {source="ABA"}
property_value: UBPROP:0000001 "The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000101", ontology="TAO", source="ZFIN:curator"}
@@ -11570,7 +11412,7 @@ relationship: capable_of GO:0044058 ! regulation of digestive system process
relationship: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0005290 ! myelencephalon
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010486", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008)", source="http://bgee.unil.ch/"}
@@ -11619,7 +11461,7 @@ relationship: innervates UBERON:0000966 ! retina
relationship: part_of UBERON:0002104 ! visual system
relationship: part_of UBERON:0003931 ! diencephalic white matter
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI
property_value: editor_note "relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with'" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
@@ -11665,7 +11507,7 @@ relationship: develops_from UBERON:0010285 {source="ZFA"} ! midbrain basal plate
relationship: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0002298 ! brainstem
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI
property_value: UBPROP:0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001367", ontology="VHOG", source="DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)", source="http://bgee.unil.ch/"}
[Term]
@@ -11751,7 +11593,7 @@ relationship: has_part CL:0000071 {source="AEO"} ! blood vessel endothelial cell
relationship: has_part UBERON:0007500 {source="EHDAA2"} ! epithelial tube open at both ends
relationship: has_quality PATO:0002045 ! dendritic
relationship: part_of UBERON:0004537 ! blood vasculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011004", ontology="AAO", source="AAO:EJS"}
@@ -11793,7 +11635,7 @@ relationship: adjacent_to UBERON:0001766 ! anterior chamber of eyeball
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: part_of UBERON:0000964 ! cornea
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
[Term]
id: UBERON:0001986
@@ -11857,7 +11699,7 @@ xref: Wikipedia:Gray_matter
xref: ZFA:0001681
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: composed_primarily_of GO:0043025 ! neuronal cell body
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002197", ontology="TAO", source="ZFIN:curator"}
[Term]
@@ -11907,7 +11749,7 @@ relationship: only_in_taxon NCBITaxon:89593 ! Craniata
relationship: overlaps UBERON:0002298 {notes="modified-source-relation", source="ABA"} ! brainstem
relationship: present_in_taxon NCBITaxon:7762 {source="PMID:8932866"}
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0001894 {source="ABA"}
property_value: UBPROP:0000001 "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010150", ontology="AAO", source="AAO:BJB"}
@@ -11936,7 +11778,7 @@ relationship: composed_primarily_of UBERON:0000055 ! vessel
relationship: has_part UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0007798 ! vascular system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "see also: vascular system. Consider merging?" xsd:string
property_value: UBPROP:0000007 "vascular" xsd:string
@@ -12250,8 +12092,8 @@ intersection_of: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0002323 ! coelemic cavity lumen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" xsd:string
[Term]
@@ -12314,7 +12156,7 @@ relationship: has_part CL:0005000 {source="ZFA"} ! spinal cord interneuron
relationship: immediate_transformation_of UBERON:0006241 {evidence="definitional"} ! future spinal cord
relationship: part_of UBERON:0001017 ! central nervous system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI
property_value: editor_note "TODO - add superclass to unify with VNC?" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb" xsd:string
@@ -12364,7 +12206,7 @@ relationship: continuous_with UBERON:0002240 ! spinal cord
relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: has_part UBERON:0001896 ! medulla oblongata
relationship: has_part UBERON:0001943 ! midbrain tegmentum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001890 {notes="we apply a strict definition"}
property_value: RO:0002171 UBERON:0002037 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0002314 {notes="we apply a strict definition"}
@@ -12408,8 +12250,8 @@ xref: Wikipedia:White_matter
xref: ZFA:0001682
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: composed_primarily_of UBERON:0006135 ! myelinated nerve fiber
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929]." xsd:string {source="FMA:83929"}
property_value: UBPROP:0000001 "Multi-tissue structure comprised largely of myelinated axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002142", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001764", ontology="VHOG", source="DOI:10.1038/nature09614 Nave KA, Myelination and support of axonal integrity by glia. Nature (2010)", source="http://bgee.unil.ch/"}
@@ -12498,7 +12340,7 @@ relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -12547,7 +12389,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -12596,8 +12438,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -12815,7 +12657,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -13040,7 +12882,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -13138,7 +12980,7 @@ intersection_of: has_potential_to_develop_into UBERON:0000965 ! lens of camera-t
relationship: developmentally_induced_by UBERON:0004128 ! optic vesicle
relationship: has_potential_to_develop_into UBERON:0000965 ! lens of camera-type eye
relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
property_value: UBPROP:0000001 "Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000122", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006)" xsd:string {source="NCBIBook:NBK53175"}
@@ -13177,7 +13019,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -13226,7 +13068,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -13279,7 +13121,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -13336,7 +13178,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -13367,7 +13209,7 @@ is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0034705 {source="EHDAA2"} ! developing neuroepithelium
relationship: develops_from UBERON:0003072 ! optic cup
relationship: part_of UBERON:0001894 ! diencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
property_value: UBPROP:0000001 "The evagination from the neural tube of the developing embryo which develops the optic cup at its extremity; the stalk persists as the optic nerve. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000223", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/optic+stalk"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000223", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -13457,7 +13299,7 @@ intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -13981,7 +13823,7 @@ relationship: developmentally_induced_by UBERON:0004880 ! chordamesoderm
relationship: develops_from UBERON:0002346 {source="GO-def"} ! neurectoderm
relationship: develops_from UBERON:0003071 {source="ZFA"} ! eye primordium
relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
[Term]
@@ -14785,7 +14627,7 @@ xref: Wikipedia:Myelencephalon
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004733 ! segmental subdivision of hindbrain
relationship: immediate_transformation_of UBERON:0010096 {evidence="definitional"} ! future myelencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:7955
property_value: UBPROP:0000001 "The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000456", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/myelencephalon"}
property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000456", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"}
@@ -15088,7 +14930,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -16226,7 +16068,7 @@ xref: SCTID:280860001
xref: Wikipedia:Ciliary_processes
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0001775 ! ciliary body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb" xsd:string
@@ -17032,7 +16874,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -17044,7 +16885,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -17148,10 +16989,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -17160,15 +16998,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -17213,10 +17047,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -17227,15 +17058,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -17243,34 +17071,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -17279,7 +17098,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -17449,7 +17267,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -17500,7 +17318,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -17708,7 +17526,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -17798,7 +17616,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -18055,6 +17873,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -18187,7 +18032,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -18235,7 +18080,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -18313,7 +18158,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -18556,13 +18401,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -18897,7 +18735,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -18909,7 +18746,6 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
is_a: RO:0002323 ! mereotopologically related to
@@ -19035,7 +18871,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -19225,12 +19061,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -19475,10 +19322,8 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -19486,7 +19331,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
domain: UBERON:0000122 ! neuron projection bundle
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -19529,8 +19373,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -19586,7 +19430,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19635,7 +19478,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -19695,7 +19537,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -19769,7 +19611,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19955,7 +19796,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -20345,10 +20185,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -20357,7 +20195,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/src/ontology/subsets/eye_upper_slim.owl b/src/ontology/subsets/eye_upper_slim.owl
index b40240ccd..5834aa177 100644
--- a/src/ontology/subsets/eye_upper_slim.owl
+++ b/src/ontology/subsets/eye_upper_slim.owl
@@ -10,10 +10,8 @@
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
- xmlns:caro="http://purl.obolibrary.org/obo/caro#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
- xmlns:fbbt="http://purl.obolibrary.org/obo/fbbt#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo2="http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/"
xmlns:pato="http://purl.obolibrary.org/obo/pato#"
@@ -31,8 +29,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-09-21
+
+ 2023-10-19
@@ -99,7 +97,7 @@ We don't have definitions of 'meaning' or 'expression'
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
@@ -273,18 +271,6 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
-
-
-
-
-
-
-
-
-
-
-
-
@@ -315,6 +301,19 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
+
+
+
+ CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
+ A synonym type for describing abbreviations or initalisms
+
+
+ 2023-03-03
+ abbreviation
+
+
+
+
@@ -675,22 +674,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -699,17 +682,6 @@ WHERE {
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -749,46 +721,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1043,14 +975,6 @@ WHERE {
-
-
-
-
-
-
-
-
@@ -1547,12 +1471,6 @@ WHERE {
-
-
-
-
-
-
@@ -2016,14 +1934,7 @@ WHERE {
-
- http://xmlns.com/foaf/0.1/depicted_by
- uberon
- depicted_by
- true
- depicted_by
- depicted by
-
+
@@ -2222,7 +2133,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
unfolds_in
BFO:0000066
external
- gene_ontology
occurs_in
@@ -2917,7 +2827,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
surface of
2D boundary of
- boundary_of
@@ -2927,7 +2836,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
-
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
@@ -2943,7 +2851,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
has_boundary
has 2D boundary
has 2D boundary
- has_boundary
@@ -3292,23 +3199,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and a material anatomical entity that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
- BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)
- RO:0002100
- fly_anatomy.ontology
- has_soma_location
has soma location
-
-
-
- Relation between a neuron and an anatomical structure that its soma is part of.
-
-
@@ -3320,7 +3216,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3347,17 +3242,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
))))))
- RO:0002101
- fly_anatomy.ontology
- fasciculates_with
fasciculates with
-
-
-
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
-
-
@@ -3403,27 +3289,18 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
- Relation between an anatomical structure and a neuron that chemically synapses to it.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))
RO:0002103
- fly_anatomy.ontology
uberon
synapsed_by
synapsed_by
synapsed by
synapsed by
-
-
-
- Relation between an anatomical structure and a neuron that chemically synapses to it.
-
-
@@ -3462,16 +3339,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
synapsed in
- BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))
http://purl.obolibrary.org/obo/BFO_0000051 some (
http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (
http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))
- RO:0002110
- fly_anatomy.ontology
- has_postsynaptic_terminals_in
- Relation between a neuron and the structure in which its dendrite receives synapses.
has postsynaptic terminal in
@@ -3490,12 +3362,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
synapses in
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))
- RO:0002113
- fly_anatomy.ontology
- has_presynaptic_terminals_in
has presynaptic terminal in
@@ -3519,16 +3387,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
- Relation between a neuron and an anatomical structure that it chemically synapses to.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))
- RO:0002120
- fly_anatomy.ontology
- synapsed_to
N1 synapsed_to some N2
Expands to:
N1 SubclassOf (
@@ -3538,12 +3401,6 @@ N1 SubclassOf (
‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
-
-
-
- Relation between a neuron and an anatomical structure that it chemically synapses to.
-
-
@@ -3558,25 +3415,13 @@ N1 SubclassOf (
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synapse in
<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)
- RO:0002130
- fly_anatomy.ontology
- has_synaptic_terminals_in
- expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
has synaptic terminal in
-
-
-
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
-
-
@@ -3690,26 +3535,17 @@ N1 SubclassOf (
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))
RO:0002134
- fly_anatomy.ontology
uberon
innervates
innervates
innervates
innervates
-
-
-
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
@@ -4189,7 +4025,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.false
RO:0002211
external
- gene_ontology
regulates
@@ -4218,7 +4053,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002212
external
- gene_ontology
negatively_regulates
@@ -4252,7 +4086,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002213
external
- gene_ontology
positively_regulates
@@ -7269,6 +7102,37 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is regulated by the small molecule continuant
+
+ 2020-04-22T20:27:26Z
+ has small molecule regulator
+
+
+
+
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is activated by the small molecule continuant
+
+ 2020-04-22T20:28:37Z
+ RO:0012001
+ external
+ has_small_molecule_activator
+ has_small_molecule_activator
+ has small molecule activator
+ has small molecule activator
+
+
+
+
@@ -7289,6 +7153,32 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process
+
+ 2020-06-24T13:15:17Z
+ is small molecule regulator of
+
+
+
+
+
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that activates the process
+
+ 2020-06-24T13:15:26Z
+ is small molecule activator of
+ https://wiki.geneontology.org/Is_small_molecule_activator_of
+
+
+
+
@@ -8047,283 +7937,6 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CARO:0000000
- Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
- anatomical entity
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CAROC:Brownsville2014
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
- CARO:0000003
-
- Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
- connected anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical entity that has mass.
- CARO:0000006
-
- material anatomical entity
-
-
-
-
-
-
-
-
- Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell.
- CARO:0000012
- MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-
-MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
- multicellular organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
-
- 10.7.2011
-
- gross anatomical part
-
-
-
-
-
-
-
-
- Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
- Melissa Haendel
- 9/18/11
- organism or virus or viroid
- organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical structure that has more than one cell as a part.
- djs93
- Sun Feb 27 10:53:00 GMT 2011
- CARO:0010000
-
- multicellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
-
-
-
-
-
-
-
-
-
- An individual member of a clade of cellular organisms.
-
- 7.16.2011
- CARO:0010004
- A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
- cellular organism
-
-
-
-
-
-
-
-
- Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them.
- Important for alignment with Darwin Core class "Organism".
- biological entity
-
-
-
-
-
-
-
- A carboxylic acid containing one or more amino groups.
- chebi_ontology
- Aminocarbonsaeure
- Aminokarbonsaeure
- Aminosaeure
- amino acids
- CHEBI:33709
-
-
-
-
- A carboxylic acid containing one or more amino groups.
- ANON:ANON
-
-
-
-
- Aminocarbonsaeure
- ChEBI:
-
-
-
-
- Aminokarbonsaeure
- ChEBI:
-
-
-
-
- Aminosaeure
- ChEBI:
-
-
-
-
- amino acids
- ChEBI:
-
-
-
-
-
-
-
- Any molecular entity that contains carbon.
- chebi_ontology
- organic compounds
- organic entity
- organic molecular entities
- CHEBI:50860
-
-
-
-
- Any molecular entity that contains carbon.
- ANON:ANON
-
-
-
-
- organic compounds
- ChEBI:
-
-
-
-
- organic entity
- ChEBI:
-
-
-
-
- organic molecular entities
- ChEBI:
-
-
-
-
@@ -8722,7 +8335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
HSC
-
+
@@ -8766,13 +8379,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BFU-E
-
+
CFU-E
-
+
@@ -8858,21 +8471,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -9085,7 +8698,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -9430,6 +9043,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
+
BTO:0002606
CALOHA:TS-0415
FBbt:00005144
@@ -9437,6 +9051,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neuroglial cell
neuroglia
+
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
glial cell
@@ -9625,20 +9240,20 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -9766,10 +9381,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -9819,7 +9432,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -9942,7 +9555,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CALOHA:TS-0868
FMA:86740
photoreceptor cell
- https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
+ https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
@@ -10708,7 +10321,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -11721,15 +11334,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
AC
doi:10.1038/s41598-020-66092-9
-
+
ACs
doi:10.1038/s41598-020-66092-9
+
-
@@ -11784,10 +11397,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -12165,15 +11776,15 @@ radial glial cells acting as neural progenitors throughout life.
RGC
doi:10.1038/s41598-020-66092-9
-
+
RGCs
doi:10.1038/s41598-020-66092-9
+
-
@@ -12209,15 +11820,15 @@ radial glial cells acting as neural progenitors throughout life.
HC
doi:10.1038/s41598-020-66092-9
-
+
HCs
doi:10.1038/s41598-020-66092-9
+
-
@@ -12282,23 +11893,23 @@ radial glial cells acting as neural progenitors throughout life.
BC
doi:10.1038/s41598-020-66092-9
-
+
BCs
doi:10.1038/s41598-020-66092-9
+
-
BPs
GSE137537
+
-
@@ -12536,6 +12147,12 @@ radial glial cells acting as neural progenitors throughout life.
erythroblast
+
+
+
+
+ true
+
@@ -12544,12 +12161,6 @@ radial glial cells acting as neural progenitors throughout life.
ISBN:0721601464
PMID:18174176
-
-
-
-
- true
-
@@ -13240,13 +12851,11 @@ radial glial cells acting as neural progenitors throughout life.
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -13659,8 +13268,6 @@ radial glial cells acting as neural progenitors throughout life.
Any muscle cell in which the fibers are not organised into sarcomeres.
-
-
non-striated muscle cell
@@ -13739,7 +13346,9 @@ radial glial cells acting as neural progenitors throughout life.
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -14476,35 +14085,6 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Any process that modulates levels of neurotransmitter.
- biological_process
- GO:0001505
- regulation of neurotransmitter levels
-
-
-
-
- Any process that modulates levels of neurotransmitter.
- GOC:jl
-
-
-
-
@@ -15244,32 +14824,32 @@ plexiform layer.
-
-
+
+
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -15966,24 +15546,7 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006866
biological_process
@@ -16445,7 +16008,6 @@ plexiform layer.
-
@@ -20004,8 +19566,8 @@ plexiform layer.
https://github.com/geneontology/go-ontology/issues/21881
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
- biological condensate
cellular_component
+ biological condensate
GO:0043228
non-membrane-bounded organelle
@@ -20756,25 +20318,9 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
+ https://github.com/geneontology/go-ontology/issues/25943
Wikipedia:Organogenesis
development of an organ
organogenesis
@@ -21460,9 +21006,11 @@ plexiform layer.
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
+ https://github.com/geneontology/go-ontology/issues/24200
establishment of localisation
biological_process
GO:0051234
+
@@ -22377,24 +21925,7 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
mah
2010-03-08T03:32:18Z
@@ -23431,14 +22962,15 @@ plexiform layer.
-
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
+ https://github.com/geneontology/go-ontology/issues/24200
kmv
2019-08-12T18:01:37Z
cellular_component
GO:0110165
+
cellular anatomical entity
@@ -23686,25 +23218,8 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
@@ -24680,9 +24195,7 @@ plexiform layer.
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
- trait
quality
PATO:0000001
quality
@@ -24693,12 +24206,6 @@ plexiform layer.
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
PATOC:GVG
-
-
-
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
- PATOC:GVG
-
@@ -24794,28 +24301,6 @@ plexiform layer.
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- quality
- PATO:0000125
-
-
-
- For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
- mass
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- PATOC:GVG
-
-
-
-
@@ -25117,7 +24602,6 @@ plexiform layer.
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
- multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
@@ -25952,27 +25436,6 @@ plexiform layer.
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
-
- 2014-12-12T08:41:11Z
- quality
- PATO:0010000
- What counts as maximally connected may be relative to some specification of granularity.
- maximally connected
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
- GOC:dos
-
-
-
-
@@ -27300,7 +26763,7 @@ plexiform layer.
-
+
@@ -27341,14 +26804,14 @@ plexiform layer.
camera-type eye
-
+
-
+
definitional
@@ -27992,7 +27455,6 @@ plexiform layer.
-
@@ -28449,7 +27911,7 @@ plexiform layer.
-
+
The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)
@@ -28474,7 +27936,7 @@ plexiform layer.
external ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png
-
+
@@ -28487,7 +27949,7 @@ plexiform layer.
-
+
EHDAA2
@@ -28856,7 +28318,7 @@ plexiform layer.
-
+
@@ -28892,14 +28354,14 @@ plexiform layer.
gastrula stage
-
+
-
+
BILS
@@ -29165,7 +28627,7 @@ plexiform layer.
-
+
@@ -29238,7 +28700,7 @@ plexiform layer.
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -29251,7 +28713,7 @@ plexiform layer.
-
+
exceptions in some taxa
@@ -29376,15 +28838,15 @@ plexiform layer.
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -29426,34 +28888,34 @@ plexiform layer.
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
-
+
Bgee:AN
@@ -29757,7 +29219,7 @@ plexiform layer.
-
+
@@ -29799,14 +29261,14 @@ plexiform layer.
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -31139,7 +30601,7 @@ plexiform layer.
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -31177,14 +30639,14 @@ plexiform layer.
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -31237,7 +30699,7 @@ plexiform layer.
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -31274,14 +30736,14 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -31326,7 +30788,7 @@ plexiform layer.
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -31371,7 +30833,7 @@ plexiform layer.
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -31384,7 +30846,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -31606,7 +31068,7 @@ plexiform layer.
-
+
@@ -31672,14 +31134,14 @@ plexiform layer.
cranial nerve II
-
+
-
+
EHDAA2
@@ -31823,7 +31285,7 @@ plexiform layer.
-
+
@@ -31900,14 +31362,14 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb
-
+
-
+
MA
@@ -31985,7 +31447,7 @@ plexiform layer.
-
+
@@ -32010,7 +31472,7 @@ plexiform layer.
-
+
The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
requires review for applicability to invertebrate structures, e.g. synganglion
@@ -32073,11 +31535,11 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb
-
+
-
+
@@ -32090,13 +31552,13 @@ plexiform layer.
-
+
FMA
-
+
Bgee:AN
@@ -32397,9 +31859,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -32424,7 +31886,7 @@ plexiform layer.
-
+
@@ -32480,44 +31942,44 @@ plexiform layer.
cornea
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
-
+
-
+
MA
-
+
MA
-
+
FMA-isa
-
+
definitional
@@ -32706,10 +32168,10 @@ plexiform layer.
-
-
-
-
+
+
+
+
The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
@@ -32760,44 +32222,44 @@ plexiform layer.
retina
http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png
-
+
-
+
-
+
-
+
-
+
FMA
-
+
FMA
-
+
FMA
-
+
EHDAA2
@@ -32871,8 +32333,8 @@ plexiform layer.
-
-
+
+
@@ -32908,24 +32370,24 @@ plexiform layer.
eye
-
+
-
+
-
+
PMID:21062451
-
+
PMID:21062451
@@ -33530,7 +32992,7 @@ plexiform layer.
-
+
@@ -33583,14 +33045,14 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -33678,7 +33140,7 @@ plexiform layer.
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -33725,7 +33187,7 @@ plexiform layer.
central nervous system
-
+
@@ -33739,7 +33201,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -34486,7 +33948,7 @@ plexiform layer.
-
+
Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
AEO:0000111
BTO:0002422
@@ -34511,14 +33973,14 @@ plexiform layer.
mesothelium
http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg
-
+
-
+
FMA
@@ -34891,7 +34353,7 @@ plexiform layer.
-
+
A tube extending from the mouth to the anus.
@@ -34931,14 +34393,14 @@ plexiform layer.
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -35018,7 +34480,7 @@ plexiform layer.
-
+
The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].
BTO:0000654
@@ -35041,7 +34503,7 @@ plexiform layer.
ciliary muscle
http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png
-
+
@@ -35060,7 +34522,7 @@ plexiform layer.
-
+
FMA
@@ -35201,7 +34663,7 @@ plexiform layer.
-
+
@@ -35253,14 +34715,14 @@ plexiform layer.
eyelid
https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg
-
+
-
+
multiple
@@ -35555,7 +35017,7 @@ plexiform layer.
-
+
@@ -35598,14 +35060,14 @@ plexiform layer.
iris
-
+
-
+
XAO
@@ -35677,7 +35139,7 @@ plexiform layer.
-
+
@@ -35729,14 +35191,14 @@ plexiform layer.
corneal epithelium
http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png
-
+
-
+
ISBN:0781772214
@@ -35832,16 +35294,16 @@ plexiform layer.
-
-
+
+
-
-
+
+
@@ -35883,44 +35345,44 @@ plexiform layer.
sclera
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
-
+
-
+
FMA
-
+
ZFA
-
+
ISBN:0781772214
-
+
cjm
ISBN:0781772214
Wikipedia
@@ -35980,7 +35442,7 @@ plexiform layer.
-
+
@@ -36019,14 +35481,14 @@ plexiform layer.
ciliary body
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
ISBN:0781772214
@@ -36074,14 +35536,14 @@ plexiform layer.
-
+
-
+
@@ -36144,24 +35606,24 @@ plexiform layer.
optic choroid
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
MA
-
+
Wikipedia
@@ -36261,7 +35723,7 @@ plexiform layer.
-
+
@@ -36310,14 +35772,14 @@ plexiform layer.
substantia propria of cornea
http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png
-
+
-
+
cjm
ISBN:0781772214
Wikipedia
@@ -36394,9 +35856,9 @@ plexiform layer.
-
-
-
+
+
+
A double layer covering the ciliary body that produces aqueous humor.
BTO:0001770
@@ -36416,15 +35878,15 @@ plexiform layer.
ciliary epithelium
-
+
-
+
-
+
@@ -36437,19 +35899,19 @@ plexiform layer.
-
+
MA
-
+
MP
-
+
Wikipedia
@@ -36572,7 +36034,7 @@ plexiform layer.
-
+
@@ -36633,14 +36095,14 @@ plexiform layer.
pigmented layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
-
+
Wikipedia
@@ -36744,7 +36206,7 @@ plexiform layer.
-
+
@@ -36778,14 +36240,14 @@ plexiform layer.
photoreceptor layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
-
+
ZFA
@@ -36958,7 +36420,7 @@ plexiform layer.
-
+
@@ -37005,14 +36467,14 @@ plexiform layer.
outer nuclear layer of retina
-
+
-
+
soma
ZFA
@@ -37350,7 +36812,7 @@ plexiform layer.
-
+
@@ -37409,7 +36871,7 @@ plexiform layer.
ganglionic layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
@@ -37422,7 +36884,7 @@ plexiform layer.
-
+
FMA
@@ -37498,7 +36960,7 @@ plexiform layer.
-
+
@@ -37554,14 +37016,14 @@ plexiform layer.
nerve fiber layer of retina
-
+
-
+
FMA
@@ -37939,7 +37401,7 @@ plexiform layer.
-
+
@@ -37975,14 +37437,14 @@ plexiform layer.
aqueous humor of eyeball
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
FMA def states A and P
located_in in EHDAA2
VHOG
@@ -38164,7 +37626,7 @@ plexiform layer.
-
+
@@ -38188,7 +37650,7 @@ plexiform layer.
vitreous body
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
@@ -38201,7 +37663,7 @@ plexiform layer.
-
+
neural ectoderm of optic cup
ISBN:0781772214
@@ -38336,8 +37798,8 @@ plexiform layer.
-
-
+
+
@@ -38370,24 +37832,24 @@ plexiform layer.
anterior segment of eyeball
http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png
-
+
-
+
-
+
FMA
-
+
cjm
@@ -38438,8 +37900,8 @@ plexiform layer.
-
-
+
+
@@ -38469,24 +37931,24 @@ plexiform layer.
posterior segment of eyeball
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
FMA
-
+
cjm
@@ -38522,9 +37984,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -38574,15 +38036,15 @@ plexiform layer.
conjunctiva
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png
-
+
-
+
-
+
@@ -38595,19 +38057,19 @@ plexiform layer.
-
+
cjm
-
+
MA
-
+
ISBN:0781772214
@@ -38671,7 +38133,7 @@ plexiform layer.
-
+
The most anterior region of the brain including both the telencephalon and diencephalon.
@@ -38718,14 +38180,14 @@ plexiform layer.
forebrain
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
definitional
@@ -38801,14 +38263,14 @@ plexiform layer.
-
+
-
+
The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].
developmental relationships need revised
@@ -38861,24 +38323,24 @@ plexiform layer.
midbrain
http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG
-
+
-
+
-
+
definitional
-
+
Bgee:AN
@@ -38981,14 +38443,14 @@ plexiform layer.
-
+
-
+
The division of the forebrain that develops from the foremost primary cerebral vesicle.
@@ -39051,24 +38513,24 @@ plexiform layer.
diencephalon
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
-
+
definitional
-
+
definitional
@@ -39506,7 +38968,7 @@ plexiform layer.
-
+
Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].
Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]
@@ -39546,14 +39008,14 @@ plexiform layer.
midbrain tegmentum
http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png
-
+
-
+
ZFA
@@ -39732,8 +39194,8 @@ plexiform layer.
-
-
+
+
@@ -39746,7 +39208,7 @@ plexiform layer.
-
+
@@ -39803,34 +39265,34 @@ plexiform layer.
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
-
+
-
+
-
+
-
+
AEO
-
+
EHDAA2
-
+
GO:0072360
@@ -40189,7 +39651,7 @@ plexiform layer.
-
+
@@ -40202,7 +39664,7 @@ plexiform layer.
-
+
The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].
@@ -40253,25 +39715,25 @@ plexiform layer.
hindbrain
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
-
+
modified-source-relation
ABA
-
+
Bgee:AN
@@ -41090,7 +40552,7 @@ plexiform layer.
-
+
Vasculature that is part of the eye region.
not part of the eye in ZFA. Note this changed to a blood vessel in ZFA
@@ -41113,14 +40575,14 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb
-
+
-
+
ISBN:0781772214
@@ -41179,7 +40641,7 @@ plexiform layer.
-
+
@@ -41213,14 +40675,14 @@ plexiform layer.
musculoskeletal system
-
+
-
+
check ctenophore
@@ -41358,15 +40820,15 @@ plexiform layer.
-
+
-
-
+
+
Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
TODO - add superclass to unify with VNC?
@@ -41425,34 +40887,34 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb
-
+
-
+
-
+
-
+
ZFA
-
+
definitional
-
+
definitional
@@ -41894,7 +41356,7 @@ plexiform layer.
-
+
@@ -41935,14 +41397,14 @@ plexiform layer.
coelemic cavity lumen
-
+
-
+
definitional
@@ -42050,9 +41512,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -42107,15 +41569,15 @@ plexiform layer.
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -42134,19 +41596,19 @@ plexiform layer.
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -42231,8 +41693,8 @@ plexiform layer.
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -42278,11 +41740,11 @@ plexiform layer.
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -42295,13 +41757,13 @@ plexiform layer.
-
+
GOTAX:0000352
-
+
ZFA
@@ -42414,12 +41876,12 @@ plexiform layer.
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -42459,66 +41921,66 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -42901,14 +42363,14 @@ plexiform layer.
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -42951,24 +42413,24 @@ plexiform layer.
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -43033,8 +42495,8 @@ plexiform layer.
-
-
+
+
@@ -43060,11 +42522,11 @@ plexiform layer.
iris epithelium
-
+
-
+
@@ -43077,13 +42539,13 @@ plexiform layer.
-
+
MA
-
+
MP
@@ -43233,7 +42695,7 @@ plexiform layer.
-
+
Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.
Do not merge with neurogenic placode
Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons
@@ -43253,7 +42715,7 @@ plexiform layer.
cranial placode
-
+
@@ -43266,7 +42728,7 @@ plexiform layer.
-
+
PMID:11523831
PMID:22512454
@@ -43471,7 +42933,7 @@ plexiform layer.
-
+
@@ -43484,7 +42946,7 @@ plexiform layer.
-
+
The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.
consider adding class for organizer. Consider adding separate class for isthmus as a structure
Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG]
@@ -43514,11 +42976,11 @@ plexiform layer.
midbrain-hindbrain boundary
-
+
-
+
@@ -43532,13 +42994,13 @@ plexiform layer.
-
+
ZFA
-
+
ZFA
@@ -43703,7 +43165,7 @@ plexiform layer.
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -43728,14 +43190,14 @@ plexiform layer.
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -43977,7 +43439,7 @@ plexiform layer.
-
+
@@ -44015,7 +43477,7 @@ plexiform layer.
eye primordium
-
+
@@ -44028,7 +43490,7 @@ plexiform layer.
-
+
PMID:16496288
XAO
@@ -44084,8 +43546,8 @@ plexiform layer.
-
-
+
+
@@ -44114,24 +43576,24 @@ plexiform layer.
optic cup
-
+
-
+
-
+
ZFA
-
+
ZFA
@@ -44196,7 +43658,7 @@ plexiform layer.
-
+
@@ -44237,7 +43699,7 @@ plexiform layer.
lens placode
http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png
-
+
@@ -44250,7 +43712,7 @@ plexiform layer.
-
+
ZFA
@@ -44314,9 +43776,9 @@ plexiform layer.
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -44348,34 +43810,34 @@ plexiform layer.
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -44486,7 +43948,7 @@ plexiform layer.
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -44515,7 +43977,7 @@ plexiform layer.
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -44528,7 +43990,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -44640,7 +44102,7 @@ plexiform layer.
-
+
@@ -44684,7 +44146,7 @@ plexiform layer.
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -44697,7 +44159,7 @@ plexiform layer.
-
+
EHDAA2
VHOG
@@ -44781,15 +44243,15 @@ plexiform layer.
-
-
+
+
-
+
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
@@ -44809,15 +44271,15 @@ plexiform layer.
heart primordium
-
+
-
+
-
+
@@ -44830,19 +44292,19 @@ plexiform layer.
-
+
ZFA
-
+
ZFA
-
+
XAO
@@ -44897,8 +44359,8 @@ plexiform layer.
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -44925,11 +44387,11 @@ plexiform layer.
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -44948,13 +44410,13 @@ plexiform layer.
-
+
VHOG:0000680
-
+
ZFA
@@ -45372,7 +44834,7 @@ plexiform layer.
-
+
Mesenchyme that is part of a developing camera-type eye.
TODO - change mesenchyme relationships to precursor_of
EHDAA2:0000485
@@ -45384,14 +44846,14 @@ plexiform layer.
UBERON:0003314
eye mesenchyme
-
+
-
+
EHDAA2
@@ -46249,7 +45711,7 @@ plexiform layer.
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -46265,14 +45727,14 @@ plexiform layer.
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -46377,7 +45839,7 @@ plexiform layer.
-
+
The part of the retina that contains neurons and photoreceptor cells[GO].
(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]
@@ -46409,14 +45871,14 @@ plexiform layer.
retinal neural layer
-
+
-
+
Bgee:AN
@@ -46674,7 +46136,7 @@ plexiform layer.
-
+
The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.
consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure
The layer of undifferentiated, proliferating cells that line the neural tube lumen
@@ -46692,7 +46154,7 @@ plexiform layer.
neural tube ventricular layer
-
+
@@ -46705,7 +46167,7 @@ plexiform layer.
-
+
NCBIBook:NBK10047
@@ -46765,7 +46227,7 @@ plexiform layer.
-
+
@@ -46789,7 +46251,7 @@ plexiform layer.
neural tube mantle layer
-
+
@@ -46802,7 +46264,7 @@ plexiform layer.
-
+
by division
NCBIBook:NBK10047
@@ -46839,7 +46301,7 @@ plexiform layer.
-
+
@@ -46856,14 +46318,14 @@ plexiform layer.
neural tube marginal layer
-
+
-
+
forms from axons
@@ -47138,9 +46600,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -47173,34 +46635,34 @@ plexiform layer.
optic vesicle
http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png
-
+
-
+
-
+
-
+
ZFA
-
+
GO-def
-
+
ZFA
@@ -47316,8 +46778,8 @@ plexiform layer.
-
-
+
+
A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
@@ -47330,24 +46792,24 @@ plexiform layer.
UBERON:0004140
primary heart field
-
+
-
+
-
+
GO:0003128
-
+
https://orcid.org/0000-0003-3308-6245
@@ -47406,7 +46868,7 @@ plexiform layer.
-
+
An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
@@ -47426,14 +46888,14 @@ plexiform layer.
heart tube
-
+
-
+
ZFA-modified
@@ -47514,7 +46976,7 @@ plexiform layer.
-
+
@@ -47530,14 +46992,14 @@ plexiform layer.
eye muscle
-
+
-
+
MA
@@ -47741,7 +47203,7 @@ plexiform layer.
-
+
A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].
Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN]
@@ -47771,14 +47233,14 @@ plexiform layer.
Descemet's membrane
https://github.com/obophenotype/uberon/issues/15
-
+
-
+
Cline et al
@@ -48561,7 +48023,7 @@ plexiform layer.
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -48577,14 +48039,14 @@ plexiform layer.
skeletal element
-
+
-
+
VSAO
@@ -48629,7 +48091,7 @@ plexiform layer.
-
+
@@ -48668,14 +48130,14 @@ plexiform layer.
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -49582,7 +49044,7 @@ plexiform layer.
-
+
Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.
Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO]
EFO:0003492
@@ -49604,14 +49066,14 @@ plexiform layer.
head mesenchyme
-
+
-
+
EHDAA2
@@ -49678,7 +49140,7 @@ plexiform layer.
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -49694,14 +49156,14 @@ plexiform layer.
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -49724,7 +49186,7 @@ plexiform layer.
-
+
The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].
The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]
@@ -49749,14 +49211,14 @@ plexiform layer.
myelencephalon
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
definitional
@@ -50283,7 +49745,7 @@ plexiform layer.
-
+
Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.
TAO:0002188
ZFA:0001688
@@ -50291,7 +49753,7 @@ plexiform layer.
UBERON:0005427
corneal primordium
-
+
@@ -50310,7 +49772,7 @@ plexiform layer.
-
+
ZFA
@@ -50333,7 +49795,7 @@ plexiform layer.
-
+
Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
@@ -50351,14 +49813,14 @@ plexiform layer.
primitive heart tube
-
+
-
+
ZFA
@@ -50561,7 +50023,7 @@ plexiform layer.
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -50571,7 +50033,7 @@ plexiform layer.
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -50590,7 +50052,7 @@ plexiform layer.
-
+
AEO-modified-relation
@@ -50649,9 +50111,9 @@ plexiform layer.
-
-
-
+
+
+
A serous sac which is the aggregate of the conjunctiva plus the conjunctival space.
EMAPA:18233
FMA:20291
@@ -50662,15 +50124,15 @@ plexiform layer.
UBERON:0005908
conjunctival sac
-
+
-
+
-
+
@@ -50683,19 +50145,19 @@ plexiform layer.
-
+
FMA
-
+
HPO:pr
-
+
MA
@@ -50950,7 +50412,7 @@ plexiform layer.
-
+
@@ -50973,14 +50435,14 @@ plexiform layer.
future diencephalon
-
+
-
+
EHDAA2
@@ -51163,7 +50625,7 @@ plexiform layer.
-
+
@@ -51187,14 +50649,14 @@ plexiform layer.
future spinal cord
-
+
-
+
EHDAA2
@@ -51231,7 +50693,7 @@ plexiform layer.
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -51246,7 +50708,7 @@ plexiform layer.
notochordal plate
-
+
@@ -51259,7 +50721,7 @@ plexiform layer.
-
+
EHDAA2
@@ -51296,7 +50758,7 @@ plexiform layer.
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -51313,14 +50775,14 @@ plexiform layer.
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -52225,7 +51687,7 @@ plexiform layer.
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -52240,14 +51702,14 @@ plexiform layer.
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -52402,8 +51864,8 @@ plexiform layer.
-
-
+
+
@@ -52430,24 +51892,24 @@ plexiform layer.
presumptive hindbrain
-
+
-
+
-
+
XAO-abduced
-
+
cjm
@@ -52504,7 +51966,7 @@ plexiform layer.
-
+
@@ -52523,14 +51985,14 @@ plexiform layer.
presumptive midbrain hindbrain boundary
-
+
-
+
ZFA
@@ -52569,7 +52031,7 @@ plexiform layer.
-
+
@@ -52586,14 +52048,14 @@ plexiform layer.
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -52692,7 +52154,7 @@ plexiform layer.
-
+
@@ -52718,7 +52180,7 @@ plexiform layer.
presumptive paraxial mesoderm
-
+
@@ -52734,7 +52196,7 @@ plexiform layer.
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -52816,7 +52278,7 @@ plexiform layer.
-
+
A neural decussation that is part of a diencephalon.
FMA:62446
diencephalon decussation
@@ -52824,7 +52286,7 @@ plexiform layer.
UBERON:0007425
decussation of diencephalon
-
+
@@ -52837,7 +52299,7 @@ plexiform layer.
-
+
Obol
@@ -52912,7 +52374,7 @@ plexiform layer.
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -52920,7 +52382,7 @@ plexiform layer.
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -52933,7 +52395,7 @@ plexiform layer.
-
+
AEO
@@ -53173,7 +52635,7 @@ plexiform layer.
-
+
An axon tract that is part of a brain.
the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts
FMA:83848
@@ -53183,14 +52645,14 @@ plexiform layer.
UBERON:0007702
tract of brain
-
+
-
+
cjm
@@ -53218,7 +52680,7 @@ plexiform layer.
-
+
Anatomical system that consists of all blood and lymph vessels.
consider merging with vasculature
The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
@@ -53235,14 +52697,14 @@ plexiform layer.
vascular system
-
+
-
+
MA
@@ -53375,7 +52837,7 @@ plexiform layer.
-
+
@@ -53392,14 +52854,14 @@ plexiform layer.
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -53495,8 +52957,8 @@ plexiform layer.
-
-
+
+
TODO - developmental relationships for lines
TAO:0007044
ZFA:0007044
@@ -53506,24 +52968,24 @@ plexiform layer.
UBERON:0009615
midbrain hindbrain boundary neural plate
-
+
-
+
-
+
ZFA
-
+
https://github.com/obophenotype/uberon/issues/438
Bgee:AN
@@ -53557,14 +53019,14 @@ plexiform layer.
-
+
-
+
@@ -53589,24 +53051,24 @@ plexiform layer.
presumptive midbrain
-
+
-
+
-
+
ZFA
-
+
ZFA
@@ -53652,7 +53114,7 @@ plexiform layer.
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -53660,14 +53122,14 @@ plexiform layer.
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -53689,7 +53151,7 @@ plexiform layer.
-
+
EFO:0003704
TAO:0005041
ZFA:0005041
@@ -53699,14 +53161,14 @@ plexiform layer.
anterior lateral plate mesoderm
-
+
-
+
ZFA
@@ -53762,14 +53224,14 @@ plexiform layer.
-
+
EHDAA2:0001315
EHDAA:1122
uberon
UBERON:0009920
optic neural crest
-
+
@@ -53782,7 +53244,7 @@ plexiform layer.
-
+
EHDAA2
@@ -53916,7 +53378,7 @@ plexiform layer.
-
+
@@ -53941,14 +53403,14 @@ plexiform layer.
eyeball of camera-type eye
-
+
-
+
FMA
@@ -53989,8 +53451,8 @@ plexiform layer.
-
-
+
+
Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.
DHBA:12322
EFO:0003567
@@ -54004,11 +53466,11 @@ plexiform layer.
midbrain basal plate
-
+
-
+
@@ -54021,13 +53483,13 @@ plexiform layer.
-
+
EHDAA2
-
+
ZFA
@@ -54055,7 +53517,7 @@ plexiform layer.
-
+
Portion of neural tube that gives rise to the midbrain.
we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed
TAO:0007039
@@ -54064,14 +53526,14 @@ plexiform layer.
UBERON:0010286
midbrain neural tube
-
+
-
+
ZFA
@@ -54098,7 +53560,7 @@ plexiform layer.
-
+
@@ -54114,14 +53576,14 @@ plexiform layer.
UBERON:0010312
immature eye
-
+
-
+
definitional
@@ -54399,8 +53861,8 @@ plexiform layer.
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -54413,11 +53875,11 @@ plexiform layer.
subdivision of skeleton
-
+
-
+
@@ -54430,13 +53892,13 @@ plexiform layer.
-
+
UBERONREF:0000003
-
+
VSAO
@@ -54513,7 +53975,7 @@ plexiform layer.
-
+
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
axial skeletal system
FMA:302077
@@ -54523,7 +53985,7 @@ plexiform layer.
postcranial axial skeletal system
http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton
-
+
@@ -54536,7 +53998,7 @@ plexiform layer.
-
+
cjm
@@ -54648,7 +54110,7 @@ plexiform layer.
-
+
Muscles within the eye (bulbus oculi).[AAO]
AAO:0010038
EMAPA:18808
@@ -54659,14 +54121,14 @@ plexiform layer.
UBERON:0011222
intra-ocular muscle
-
+
-
+
EMAPA
@@ -54936,7 +54398,7 @@ plexiform layer.
-
+
@@ -54978,7 +54440,7 @@ plexiform layer.
anterior uvea
-
+
@@ -54991,7 +54453,7 @@ plexiform layer.
-
+
MP
@@ -55767,7 +55229,7 @@ plexiform layer.
-
+
@@ -55790,7 +55252,7 @@ plexiform layer.
UBERON:0016887
entire extraembryonic component
-
+
@@ -55803,7 +55265,7 @@ plexiform layer.
-
+
AEO
@@ -56766,48 +56228,6 @@ plexiform layer.
///////////////////////////////////////////////////////////////////////////////////////
-->
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Should belong in BFO, but lives in caro for now.
-
-
-
-
-
@@ -56838,16 +56258,6 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
@@ -57698,5 +57108,5 @@ plexiform layer.
-
+
diff --git a/src/ontology/subsets/eye_upper_slim.tsv b/src/ontology/subsets/eye_upper_slim.tsv
index 163ff253e..f0cd17a94 100644
--- a/src/ontology/subsets/eye_upper_slim.tsv
+++ b/src/ontology/subsets/eye_upper_slim.tsv
@@ -1,332 +1,323 @@
?x ?label
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1005
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1054
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1062
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1069
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1076
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1082
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1092
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1107
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1113
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1120
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1126
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1132
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1139
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1146
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1153
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1162
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1174
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1182
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1187
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1193
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1199
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1207
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1213
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1219
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid122
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1225
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1231
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1237
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1245
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid125
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1253
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1262
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1270
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1278
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1291
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1298
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1305
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1312
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1320
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1331
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1339
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1348
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1355
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1423
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1436
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1444
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1469
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1479
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1485
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1491
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1497
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1508
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1531
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1542
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1552
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1564
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1573
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1582
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1593
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1599
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1607
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1613
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1619
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1625
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1635
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1644
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1651
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1659
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1667
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1673
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1680
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1686
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1696
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1716
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1728
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1741
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1750
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1760
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1769
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1777
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1799
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1810
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1825
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1832
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1838
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1844
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1849
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1854
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1860
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1866
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1873
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1879
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid19
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1900
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1906
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1912
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1919
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1927
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1939
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1946
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1953
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1961
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1972
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1978
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1984
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1993
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2000
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2011
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2017
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2029
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2043
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2056
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2062
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2074
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2081
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2086
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2098
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2104
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2110
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2127
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2135
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2151
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2157
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2163
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2175
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2187
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2196
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2203
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2209
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2217
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2226
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2236
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2246
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2252
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2259
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2265
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2271
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2280
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2290
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2296
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2303
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2370
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2415
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2421
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2507
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2514
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2521
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2550
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2566
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2634
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2671
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2711
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2753
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2760
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2769
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2838
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2850
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2860
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2873
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2882
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2943
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2972
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3012
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3018
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3108
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3124
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3222
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3238
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3254
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3308
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid335
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3367
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid343
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3434
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3451
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3473
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid349
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3602
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3657
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid366
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid37
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid372
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3801
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid382
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3839
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3851
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid389
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3894
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3909
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3948
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3960
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3982
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4144
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4168
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4207
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4221
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4247
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4279
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4306
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid440
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4414
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4426
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4435
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4443
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4456
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4474
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4490
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4503
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4513
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4524
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4536
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4545
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4565
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid457
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4582
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4587
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid46
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4640
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4654
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4661
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4707
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4726
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid474
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4750
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4775
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4791
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4798
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4812
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4819
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4827
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid484
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4851
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4865
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4889
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid493
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4931
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4939
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4947
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4955
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4963
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4975
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid499
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4992
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4999
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5014
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5029
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5066
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5118
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5126
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5143
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5172
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5188
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5198
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5208
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5213
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5222
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5233
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5243
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5251
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5277
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5286
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid529
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5296
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5311
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5319
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5335
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5345
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5354
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5365
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid538
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5380
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5397
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5407
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5420
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5455
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5468
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5491
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5500
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5508
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid551
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5536
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5545
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5551
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5558
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid559
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5594
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5611
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5620
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5653
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5667
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid569
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5693
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5701
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5715
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5721
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5729
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5748
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5754
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5759
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5765
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid581
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5826
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5830
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid599
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid604
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid611
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid622
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid629
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid63
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid637
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid644
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid650
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid662
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid715
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid732
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid752
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid767
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid822
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid872
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid889
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid902
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid907
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid916
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid922
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid936
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid942
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid950
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1018
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1026
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1033
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1040
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1046
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1056
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1071
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1077
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1084
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1090
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1096
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1103
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1110
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1117
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1126
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1138
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1146
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1151
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1157
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid116
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1163
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1171
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1177
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1183
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1189
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid119
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1195
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1201
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1209
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1217
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1226
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1234
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1242
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1252
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1259
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1266
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1273
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1281
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1292
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1300
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1309
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1316
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1392
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1400
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1425
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1435
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1441
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1447
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1453
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1464
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1487
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1498
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1508
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1520
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1529
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1538
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1549
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1555
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1563
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1569
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1575
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1581
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1591
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1600
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1607
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1615
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1623
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1629
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1636
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1642
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1652
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1672
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1684
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1697
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1706
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1716
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1725
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1733
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1755
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1766
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1781
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1788
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1794
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1800
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1805
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1810
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1816
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1822
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1829
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1835
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1856
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1862
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1868
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1875
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1890
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1897
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid19
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1904
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1912
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1923
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1929
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1935
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1944
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1951
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1962
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1968
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1980
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1994
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2007
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2013
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2025
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2032
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2037
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2049
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2056
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2073
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2081
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2097
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2103
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2109
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2121
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2133
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2142
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2149
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2155
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2163
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2172
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2182
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2192
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2198
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2205
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2211
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2217
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2231
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2237
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2244
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2309
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2354
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2360
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2445
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2452
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2459
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2488
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2504
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2572
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2609
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2649
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2691
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2698
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2707
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2776
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2788
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2798
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2811
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2820
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2881
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2910
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2950
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2956
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3046
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3062
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3160
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3176
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3192
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3246
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid330
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3305
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid336
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3372
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3389
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3411
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid346
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid35
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid353
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3540
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3595
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3739
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3777
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3789
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3832
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3847
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3886
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3898
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3920
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid404
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4082
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4106
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4145
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4159
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4185
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid421
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4217
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4244
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid43
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4352
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4364
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4373
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid438
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4381
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4394
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4412
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4428
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4441
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4451
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4462
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4474
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid448
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4483
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4503
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4520
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4525
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid457
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4578
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4592
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4599
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid463
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4645
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4664
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4688
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4713
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4729
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4736
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4750
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4757
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4765
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4789
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4803
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4827
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4869
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4877
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4885
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4893
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4901
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4913
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid493
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4930
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4937
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4952
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4967
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5004
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid502
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5056
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5064
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5081
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5110
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5126
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5136
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5146
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid515
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5151
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5160
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5171
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5181
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5189
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5215
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5224
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid523
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5234
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5249
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5257
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5273
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5283
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5292
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5303
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5318
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid533
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5335
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5345
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5358
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5393
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5406
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5429
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5438
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5446
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid545
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5474
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5483
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5489
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5496
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5532
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5549
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5558
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5591
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5605
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid563
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5631
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5639
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5653
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5659
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5667
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid568
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5686
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5692
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5697
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5703
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid575
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid58
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid586
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid593
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid601
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid608
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid614
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid626
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid679
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid696
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid716
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid731
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid786
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid836
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid853
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid866
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid871
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid880
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid886
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid900
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid906
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid914
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid922
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid969
"continuant"
"occurrent"
"independent continuant"
@@ -334,17 +325,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"specifically dependent continuant"
"material entity"
"immaterial entity"
- "anatomical entity"
- "connected anatomical structure"
- "material anatomical entity"
- "multicellular organism"
- "gross anatomical part"
- "organism"
- "multicellular anatomical structure"
- "cellular organism"
- "biological entity"
-
-
"cell"
"fibroblast neural crest derived"
"neuronal receptor cell"
@@ -495,7 +475,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"nuclear division"
"chromatin"
"heterochromatin"
- "regulation of neurotransmitter levels"
"action potential"
"formation of translation initiation ternary complex"
"formation of primary germ layer"
@@ -799,7 +778,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"qualitative"
"deviation (from_normal)"
"size"
- "mass"
"closure"
"structure"
"branched"
@@ -850,7 +828,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"superelliptic"
"acidophilic"
"nucleated"
- "maximally connected"
"disconnected"
"cell morphology"
"polymeric"
diff --git a/src/ontology/subsets/general_cell_types_upper_slim.json b/src/ontology/subsets/general_cell_types_upper_slim.json
index ccee65351..928860897 100644
--- a/src/ontology/subsets/general_cell_types_upper_slim.json
+++ b/src/ontology/subsets/general_cell_types_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-09-21"
+ "val" : "2023-10-19"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-09-21/subsets/general_cell_types_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-10-19/subsets/general_cell_types_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -296,9 +296,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "occurs_in"
@@ -724,168 +721,6 @@
"val" : "in_dorsal_side_of"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "lbl" : "anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
- "xrefs" : [ "CAROC:Brownsville2014" ]
- },
- "comments" : [ "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "lbl" : "connected anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
- },
- "comments" : [ "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "lbl" : "material anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical entity that has mass."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "lbl" : "multicellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
- },
- "comments" : [ "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "lbl" : "gross anatomical part",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#plus" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "10.7.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "lbl" : "organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- },
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "organism or virus or viroid"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "Melissa Haendel"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "9/18/11"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "lbl" : "multicellular anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical structure that has more than one cell as a part."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "djs93"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "Sun Feb 27 10:53:00 GMT 2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "lbl" : "cellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An individual member of a clade of cellular organisms."
- },
- "comments" : [ "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. " ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "7.16.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "lbl" : "biological entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
- },
- "comments" : [ "Important for alignment with Darwin Core class \"Organism\"." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_50860",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any molecular entity that contains carbon.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "organic compounds",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic entity",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic molecular entities",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000000",
"lbl" : "cell",
@@ -980,7 +815,7 @@
"pred" : "hasExactSynonym",
"val" : "hemopoietic stem cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HSC"
}, {
@@ -1028,7 +863,7 @@
},
"comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-M"
}, {
@@ -1088,17 +923,17 @@
"pred" : "hasExactSynonym",
"val" : "common myeloid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GEMM",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-S",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CMP",
"xrefs" : [ "ISBN:0878932437" ]
@@ -1148,11 +983,11 @@
"pred" : "hasExactSynonym",
"val" : "common lymphoid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CLP"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "ELP"
}, {
@@ -1291,7 +1126,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"
} ]
}
@@ -1489,7 +1324,7 @@
"xrefs" : [ "MESH:D009457" ]
},
"comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ],
- "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "neuroglial cell"
@@ -1505,6 +1340,10 @@
"val" : "FBbt:00005144"
}, {
"val" : "FMA:54536"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1542,15 +1381,15 @@
"val" : "marrow stromal cells",
"xrefs" : [ "PMID:11378515" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BMSC"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-F"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "MSC",
"xrefs" : [ "PMID:11378515" ]
@@ -1631,7 +1470,7 @@
"comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ],
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "APC"
} ]
@@ -1705,15 +1544,10 @@
"val" : "A cell that specializes in controlled release of one or more substances.",
"xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "BTO:0003659"
}, {
"val" : "FMA:86916"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1792,7 +1626,7 @@
"val" : "WBbt:0003675"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg"
} ]
}
@@ -1892,7 +1726,7 @@
"val" : "FMA:86740"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"
} ]
}
@@ -2395,7 +2229,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg"
} ]
}
@@ -2472,12 +2306,12 @@
"pred" : "hasExactSynonym",
"val" : "granulocyte/monocyte progenitor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GM",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "GMP",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
@@ -2518,17 +2352,12 @@
"xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
},
"comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "angioblast"
}, {
"pred" : "hasExactSynonym",
"val" : "chondroplast"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -2744,12 +2573,7 @@
"definition" : {
"val" : "A cell of the monocyte, granulocyte, or mast cell lineage.",
"xrefs" : [ "GOC:add" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000775",
@@ -2822,7 +2646,6 @@
"xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ]
},
"comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasBroadSynonym",
"val" : "interdigitating cell"
@@ -2838,10 +2661,6 @@
} ],
"xrefs" : [ {
"val" : "BTO:0004721"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -3390,7 +3209,6 @@
"val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.",
"xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "CALOHA:TS-2096"
}, {
@@ -3399,9 +3217,6 @@
"val" : "MESH:D003239"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- }, {
"pred" : "http://purl.org/dc/terms/contributor",
"val" : "https://orcid.org/0000-0003-1980-3228"
}, {
@@ -3541,12 +3356,7 @@
"definition" : {
"val" : "Any muscle cell in which the fibers are not organised into sarcomeres.",
"xrefs" : [ "GOC:DOS" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0008001",
@@ -3592,9 +3402,14 @@
"definition" : {
"val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
},
+ "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "mesenchyme cell"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -8146,7 +7961,7 @@
"pred" : "hasExactSynonym",
"val" : "non-membrane-enclosed organelle"
}, {
- "pred" : "hasNarrowSynonym",
+ "pred" : "hasRelatedSynonym",
"val" : "biological condensate"
} ],
"xrefs" : [ {
@@ -8649,6 +8464,9 @@
"val" : "Wikipedia:Organogenesis"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/25943"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -8765,6 +8583,10 @@
"xrefs" : [ "GOC:ebc" ]
},
"subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "synonyms" : [ {
+ "pred" : "hasExactSynonym",
+ "val" : "tissue remodelling"
+ } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
@@ -9143,13 +8965,16 @@
"val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.",
"xrefs" : [ "GOC:ai", "GOC:dos" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "establishment of localisation",
"xrefs" : [ "GOC:mah" ]
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -10103,8 +9928,11 @@
"val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
"xrefs" : [ "GOC:kmv" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
"val" : "kmv"
}, {
@@ -10411,7 +10239,7 @@
"val" : "http://purl.obolibrary.org/obo/IAO_0000122"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
- "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "PERSON:Daniel Schober"
@@ -11617,6 +11445,28 @@
"val" : "https://orcid.org/0000-0002-8688-6599"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/OMO_0003000",
+ "lbl" : "abbreviation",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A synonym type for describing abbreviations or initalisms"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/information-artifact-ontology/ontology-metadata/issues/122"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-4423-4370"
+ }, {
+ "pred" : "http://purl.org/dc/terms/created",
+ "val" : "2023-03-03"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/OMO_0003004",
"lbl" : "plural form",
@@ -11645,13 +11495,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.",
+ "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities",
"xrefs" : [ "PATOC:GVG" ]
},
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "trait"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
"val" : "PATO:0000072"
@@ -11739,22 +11585,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "lbl" : "mass",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.",
- "xrefs" : [ "PATOC:GVG" ]
- },
- "comments" : [ "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/pato#attribute_slim", "http://purl.obolibrary.org/obo/pato#relational_slim", "http://purl.obolibrary.org/obo/pato#scalar_slim" ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0000141",
"lbl" : "structure",
@@ -11934,9 +11764,6 @@
}, {
"pred" : "hasExactSynonym",
"val" : "multiply inhering quality of a physical entity"
- }, {
- "pred" : "hasExactSynonym",
- "val" : "multiply inhering quality of a physical entity "
}, {
"pred" : "hasExactSynonym",
"val" : "quality of a continuant"
@@ -12539,27 +12366,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "lbl" : "maximally connected",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.",
- "xrefs" : [ "GOC:dos" ]
- },
- "comments" : [ "What counts as maximally connected may be relative to some specification of granularity." ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-7073-9172"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
- "val" : "2014-12-12T08:41:11Z"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0010001",
"lbl" : "disconnected",
@@ -15198,7 +15004,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002000",
- "lbl" : "boundary_of",
+ "lbl" : "2D boundary of",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -15235,7 +15041,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002002",
- "lbl" : "has_boundary",
+ "lbl" : "has 2D boundary",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -15634,12 +15440,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a neuron and a material anatomical entity that its soma is part of."
},
- "xrefs" : [ {
- "val" : "RO:0002100"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15649,15 +15451,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some (\n and some ?Y)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15668,9 +15464,6 @@
"definition" : {
"val" : "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"
},
- "xrefs" : [ {
- "val" : "RO:0002101"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15689,9 +15482,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15728,8 +15518,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between an anatomical structure and a neuron that chemically synapses to it.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "
},
"xrefs" : [ {
"val" : "RO:0002103"
@@ -15746,18 +15535,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that has_part some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -15808,10 +15591,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "
},
- "comments" : [ "Relation between a neuron and the structure in which its dendrite receives synapses." ],
- "xrefs" : [ {
- "val" : "RO:0002110"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15824,9 +15603,6 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "synapsed in"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))"
@@ -15836,9 +15612,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15849,9 +15622,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."
},
- "xrefs" : [ {
- "val" : "RO:0002113"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15861,18 +15631,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15881,13 +15645,9 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that it chemically synapses to.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n "
},
"comments" : [ "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ],
- "xrefs" : [ {
- "val" : "RO:0002120"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15900,18 +15660,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15920,13 +15674,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
},
- "comments" : [ "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)" ],
- "xrefs" : [ {
- "val" : "RO:0002130"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15939,18 +15688,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -16019,8 +15762,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."
},
"xrefs" : [ {
"val" : "RO:0002134"
@@ -16034,18 +15776,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that ( some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -16670,9 +16406,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "regulates"
@@ -16705,9 +16438,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "negatively_regulates"
@@ -16740,9 +16470,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "positively_regulates"
@@ -20408,6 +20135,47 @@
"val" : "https://orcid.org/0000-0003-4639-4431"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "lbl" : "has small molecule regulator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:27:26Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "lbl" : "has small molecule activator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
+ },
+ "xrefs" : [ {
+ "val" : "RO:0012001"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:28:37Z"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
+ "val" : "external"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
+ "val" : "has_small_molecule_activator"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012003",
"lbl" : "acts on population of",
@@ -20434,6 +20202,41 @@
"val" : "acts_on_population_of"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "lbl" : "is small molecule regulator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:17Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "lbl" : "is small molecule activator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:26Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_small_molecule_activator_of"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012008",
"lbl" : "results in fusion of",
@@ -30497,19 +30300,6 @@
"val" : "uberon"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/cl#abbreviation",
- "lbl" : "abbreviation",
- "type" : "PROPERTY",
- "meta" : {
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/elements/1.1/date",
- "val" : "2022-03-29T15:09:49Z"
- }, {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-1773-2692"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim",
"lbl" : "blood_and_immune_upper_slim",
@@ -31072,25 +30862,6 @@
"val" : "seeAlso"
} ]
}
- }, {
- "id" : "http://xmlns.com/foaf/0.1/depicted_by",
- "lbl" : "depicted by",
- "type" : "PROPERTY",
- "meta" : {
- "xrefs" : [ {
- "val" : "http://xmlns.com/foaf/0.1/depicted_by"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "uberon"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag",
- "val" : "true"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
- "val" : "depicted_by"
- } ]
- }
} ],
"edges" : [ {
"sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
@@ -31112,74 +30883,6 @@
"sub" : "http://purl.obolibrary.org/obo/BFO_0000141",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0030000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0010000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000125"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000012"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001008"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001993"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001010"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000000",
"pred" : "is_a",
@@ -34582,10 +34285,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0048513",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0048856"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0048513",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002296",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0048583",
"pred" : "is_a",
@@ -34910,10 +34609,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0071704",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0008152"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0071704",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004007",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0071840",
"pred" : "is_a",
@@ -35042,10 +34737,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0098657",
"pred" : "http://purl.obolibrary.org/obo/RO_0002339",
"obj" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0098657",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0098793",
"pred" : "is_a",
@@ -35154,10 +34845,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0099537",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0099536"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0110165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0110165",
"pred" : "is_a",
@@ -35214,10 +34901,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_1901576",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0071704"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_1901576",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004008",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_1902105",
"pred" : "is_a",
@@ -35410,10 +35093,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0000117",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001018"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0000141",
"pred" : "is_a",
@@ -35586,10 +35265,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0002505",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0001404"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000141"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0010001",
"pred" : "is_a",
@@ -35976,10 +35651,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002497",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
"pred" : "is_a",
@@ -40125,10 +39796,30 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0011002",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012000"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012003",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002596"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002598"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012008",
"pred" : "subPropertyOf",
@@ -40433,36 +40124,20 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0003000",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012005"
}, {
"sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to"
} ],
"logicalDefinitionAxioms" : [ {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010000"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0000125"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001993"
- } ]
- }, {
"definedClassId" : "http://purl.obolibrary.org/obo/CL_0000006",
"genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000197", "http://purl.obolibrary.org/obo/CL_0000540" ],
"restrictions" : [ {
@@ -41882,13 +41557,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000000"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048513",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
- "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0048583",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -42050,13 +41718,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002215",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0099500"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071704",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0072175",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0035148" ],
@@ -42106,19 +41767,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005604"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098657",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002338",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0098796",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ],
@@ -42218,13 +41866,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901576",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_1902105",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -42882,7 +42523,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002002",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040", "http://purl.obolibrary.org/obo/CARO_0000003" ],
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
diff --git a/src/ontology/subsets/general_cell_types_upper_slim.obo b/src/ontology/subsets/general_cell_types_upper_slim.obo
index 759d7f857..c7b121e24 100644
--- a/src/ontology/subsets/general_cell_types_upper_slim.obo
+++ b/src/ontology/subsets/general_cell_types_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-09-21/subsets/general_cell_types_upper_slim.owl
+data-version: cl/releases/2023-10-19/subsets/general_cell_types_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,13 +82,12 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/general_cell_types_upper_slim
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -147,106 +138,6 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:24431
-namespace: chebi_ontology
-def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [ANON:ANON]
-is_a: BFO:0000040 ! material entity
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -311,7 +202,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -367,7 +258,7 @@ id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
-synonym: "CFU-M" RELATED abbreviation []
+synonym: "CFU-M" RELATED OMO:0003000 []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
@@ -409,9 +300,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -429,13 +320,13 @@ name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: human_reference_atlas
-synonym: "CLP" RELATED abbreviation []
+synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
-synonym: "ELP" RELATED abbreviation []
+synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
@@ -508,7 +399,7 @@ is_a: CL:0000000 ! cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000075
@@ -661,6 +552,7 @@ name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: general_cell_types_upper_slim
+subset: human_reference_atlas
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
@@ -668,6 +560,7 @@ xref: CALOHA:TS-0415
xref: FBbt:00005144
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000133
@@ -681,9 +574,9 @@ id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -691,7 +584,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -722,7 +615,7 @@ name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
-synonym: "APC" RELATED abbreviation []
+synonym: "APC" RELATED OMO:0003000 []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
@@ -767,14 +660,12 @@ is_a: CL:0000147 ! pigment cell
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000152
@@ -820,7 +711,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000188
@@ -880,7 +771,7 @@ is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -1229,7 +1120,7 @@ is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000541
@@ -1274,9 +1165,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: human_reference_atlas
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
-synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
-synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
@@ -1328,7 +1219,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -1339,7 +1229,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -1508,12 +1397,10 @@ relationship: develops_from CL:0000049 ! common myeloid progenitor
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
-subset: human_reference_atlas
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000775
@@ -1550,7 +1437,6 @@ id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
-subset: human_reference_atlas
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
@@ -1563,7 +1449,6 @@ intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleuki
intersection_of: develops_from CL:0000763 ! myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000763 ! myeloid cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000825
@@ -1972,7 +1857,6 @@ creation_date: 2010-09-15T01:34:57Z
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -1981,7 +1865,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -2054,9 +1937,7 @@ creation_date: 2012-06-27T08:27:35Z
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
-subset: human_reference_atlas
is_a: CL:0000187 ! muscle cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0008001
@@ -2092,10 +1973,12 @@ relationship: part_of UBERON:8600004 ! visceral muscle tissue
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0009004
@@ -4581,7 +4464,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -4874,9 +4757,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048583
@@ -4947,6 +4828,7 @@ name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
+synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process
[Term]
@@ -5167,12 +5049,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051239
@@ -5405,9 +5289,6 @@ synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:50860
-relationship: has_primary_input_or_output CHEBI:50860
created_by: mah
creation_date: 2010-03-08T03:32:18Z
@@ -5587,11 +5468,6 @@ namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport
-intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:24431
-intersection_of: has_target_end_location GO:0005737 ! cytoplasm
-intersection_of: has_target_start_location GO:0005576 ! extracellular region
-relationship: has_primary_input CHEBI:24431
relationship: has_target_end_location GO:0005737 ! cytoplasm
relationship: has_target_start_location GO:0005576 ! extracellular region
@@ -5730,10 +5606,11 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -5808,9 +5685,6 @@ synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:50860
-relationship: has_primary_output CHEBI:50860
created_by: pr
creation_date: 2012-11-05T11:04:40Z
@@ -6197,8 +6071,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -6244,17 +6116,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000141
name: structure
@@ -6346,7 +6207,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -6662,16 +6522,6 @@ is_a: PATO:0001404 ! nucleate quality
relationship: dc-contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -7591,7 +7441,7 @@ intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
[Term]
id: UBERON:0000025
@@ -7692,7 +7542,7 @@ relationship: connects UBERON:0001630 ! muscle organ
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0002204 {source="OG"} ! musculoskeletal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000073", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000003 "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001286", ontology="VHOG", source="DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" xsd:string {external_ontology="FMA"}
@@ -7801,7 +7651,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological_process
@@ -8097,7 +7946,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -8249,7 +8098,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -8277,7 +8126,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -8774,7 +8623,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -8875,7 +8724,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -8950,7 +8799,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -8990,8 +8839,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -9037,7 +8886,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -9076,7 +8925,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -9266,7 +9115,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -9352,7 +9201,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073
relationship: never_in_taxon NCBITaxon:6157
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -9393,7 +9242,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -9451,8 +9300,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -9549,7 +9398,7 @@ is_a: UBERON:0015203 ! non-connected functional system
relationship: capable_of_part_of GO:0007600 ! sensory perception
relationship: overlaps UBERON:0001016 ! nervous system
relationship: part_of UBERON:0004456 ! entire sense organ system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string
@@ -9591,7 +9440,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -9703,7 +9552,7 @@ intersection_of: composed_primarily_of CL:0008002 ! skeletal muscle fiber
relationship: composed_primarily_of CL:0008002 ! skeletal muscle fiber
relationship: develops_from UBERON:0003082 ! myotome
relationship: part_of UBERON:0014892 ! skeletal muscle organ
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI
property_value: editor_note "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." xsd:string
property_value: UBPROP:0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005277", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" xsd:string {external_class="FMA:14069", ontology="FMA"}
@@ -10121,7 +9970,7 @@ relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -10170,7 +10019,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -10245,8 +10094,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -10354,7 +10203,7 @@ intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000949 ! endocrine system
relationship: capable_of GO:0046879 ! hormone secretion
relationship: part_of UBERON:0000949 ! endocrine system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI
[Term]
id: UBERON:0002371
@@ -10399,7 +10248,7 @@ relationship: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0002390 {source="FMA", source="MA"} ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string
property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string
property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"}
@@ -10628,7 +10477,7 @@ is_a: UBERON:0000062 ! organ
relationship: capable_of GO:0046903 ! secretion
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: produces UBERON:0000463 ! organism substance
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001434
property_value: UBPROP:0000007 "glandular" xsd:string
@@ -10654,7 +10503,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -10761,7 +10610,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -10798,7 +10647,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -10832,7 +10681,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -10870,7 +10719,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -10911,7 +10760,7 @@ xref: ZFA:0001056
is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure
relationship: contributes_to_morphology_of UBERON:0001630 ! muscle organ
relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: editor_note "The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere." xsd:string
property_value: UBPROP:0000001 "Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001056", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001244", ontology="VHOG", source="DOI:10.1038/sj.embor.embor920 Hollway GE, Currie PD, Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Rep.(2003)", source="http://bgee.unil.ch/"}
@@ -10942,7 +10791,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -11002,7 +10851,7 @@ intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -11578,7 +11427,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -12658,7 +12507,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -12670,7 +12518,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -12774,10 +12622,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -12786,15 +12631,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -12838,10 +12679,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -12852,15 +12690,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -12868,34 +12703,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -12904,7 +12730,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -13073,7 +12898,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -13124,7 +12949,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -13332,7 +13157,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -13422,7 +13247,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -13679,6 +13504,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -13811,7 +13663,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -13859,7 +13711,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -13937,7 +13789,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -14180,13 +14032,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -14521,7 +14366,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -14533,7 +14377,6 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
is_a: RO:0002323 ! mereotopologically related to
@@ -14659,7 +14502,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -14849,12 +14692,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -15098,17 +14952,14 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -15151,8 +15002,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -15208,7 +15059,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -15257,7 +15107,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -15317,7 +15166,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -15391,7 +15240,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -15577,7 +15425,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -15967,10 +15814,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -15979,7 +15824,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/src/ontology/subsets/general_cell_types_upper_slim.owl b/src/ontology/subsets/general_cell_types_upper_slim.owl
index 5424f8b71..cf6adf3d8 100644
--- a/src/ontology/subsets/general_cell_types_upper_slim.owl
+++ b/src/ontology/subsets/general_cell_types_upper_slim.owl
@@ -10,10 +10,8 @@
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
- xmlns:caro="http://purl.obolibrary.org/obo/caro#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
- xmlns:fbbt="http://purl.obolibrary.org/obo/fbbt#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo2="http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/"
xmlns:pato="http://purl.obolibrary.org/obo/pato#"
@@ -31,8 +29,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-09-21
+
+ 2023-10-19
@@ -99,7 +97,7 @@ We don't have definitions of 'meaning' or 'expression'
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
@@ -273,18 +271,6 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
-
-
-
-
-
-
-
-
-
-
-
-
@@ -315,6 +301,19 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
+
+
+
+ CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
+ A synonym type for describing abbreviations or initalisms
+
+
+ 2023-03-03
+ abbreviation
+
+
+
+
@@ -675,22 +674,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -699,17 +682,6 @@ WHERE {
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -749,46 +721,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1043,14 +975,6 @@ WHERE {
-
-
-
-
-
-
-
-
@@ -1547,12 +1471,6 @@ WHERE {
-
-
-
-
-
-
@@ -2016,14 +1934,7 @@ WHERE {
-
- http://xmlns.com/foaf/0.1/depicted_by
- uberon
- depicted_by
- true
- depicted_by
- depicted by
-
+
@@ -2222,7 +2133,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
unfolds_in
BFO:0000066
external
- gene_ontology
occurs_in
@@ -2917,7 +2827,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
surface of
2D boundary of
- boundary_of
@@ -2927,7 +2836,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
-
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
@@ -2943,7 +2851,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
has_boundary
has 2D boundary
has 2D boundary
- has_boundary
@@ -3280,23 +3187,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and a material anatomical entity that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
- BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)
- RO:0002100
- fly_anatomy.ontology
- has_soma_location
has soma location
-
-
-
- Relation between a neuron and an anatomical structure that its soma is part of.
-
-
@@ -3307,7 +3203,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3334,17 +3229,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
))))))
- RO:0002101
- fly_anatomy.ontology
- fasciculates_with
fasciculates with
-
-
-
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
-
-
@@ -3390,27 +3276,18 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
- Relation between an anatomical structure and a neuron that chemically synapses to it.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))
RO:0002103
- fly_anatomy.ontology
uberon
synapsed_by
synapsed_by
synapsed by
synapsed by
-
-
-
- Relation between an anatomical structure and a neuron that chemically synapses to it.
-
-
@@ -3449,16 +3326,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
synapsed in
- BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))
http://purl.obolibrary.org/obo/BFO_0000051 some (
http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (
http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))
- RO:0002110
- fly_anatomy.ontology
- has_postsynaptic_terminals_in
- Relation between a neuron and the structure in which its dendrite receives synapses.
has postsynaptic terminal in
@@ -3477,12 +3349,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
synapses in
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))
- RO:0002113
- fly_anatomy.ontology
- has_presynaptic_terminals_in
has presynaptic terminal in
@@ -3506,16 +3374,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
- Relation between a neuron and an anatomical structure that it chemically synapses to.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))
- RO:0002120
- fly_anatomy.ontology
- synapsed_to
N1 synapsed_to some N2
Expands to:
N1 SubclassOf (
@@ -3525,12 +3388,6 @@ N1 SubclassOf (
‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
-
-
-
- Relation between a neuron and an anatomical structure that it chemically synapses to.
-
-
@@ -3545,25 +3402,13 @@ N1 SubclassOf (
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synapse in
<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)
- RO:0002130
- fly_anatomy.ontology
- has_synaptic_terminals_in
- expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
has synaptic terminal in
-
-
-
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
-
-
@@ -3675,26 +3520,17 @@ N1 SubclassOf (
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))
RO:0002134
- fly_anatomy.ontology
uberon
innervates
innervates
innervates
innervates
-
-
-
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
@@ -4174,7 +4010,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.false
RO:0002211
external
- gene_ontology
regulates
@@ -4203,7 +4038,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002212
external
- gene_ontology
negatively_regulates
@@ -4237,7 +4071,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002213
external
- gene_ontology
positively_regulates
@@ -7248,6 +7081,37 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is regulated by the small molecule continuant
+
+ 2020-04-22T20:27:26Z
+ has small molecule regulator
+
+
+
+
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is activated by the small molecule continuant
+
+ 2020-04-22T20:28:37Z
+ RO:0012001
+ external
+ has_small_molecule_activator
+ has_small_molecule_activator
+ has small molecule activator
+ has small molecule activator
+
+
+
+
@@ -7268,6 +7132,32 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process
+
+ 2020-06-24T13:15:17Z
+ is small molecule regulator of
+
+
+
+
+
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that activates the process
+
+ 2020-06-24T13:15:26Z
+ is small molecule activator of
+ https://wiki.geneontology.org/Is_small_molecule_activator_of
+
+
+
+
@@ -8026,256 +7916,6 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CARO:0000000
- Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
- anatomical entity
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CAROC:Brownsville2014
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
- CARO:0000003
-
- Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
- connected anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical entity that has mass.
- CARO:0000006
-
- material anatomical entity
-
-
-
-
-
-
-
-
- Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell.
- CARO:0000012
- MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-
-MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
- multicellular organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
-
- 10.7.2011
-
- gross anatomical part
-
-
-
-
-
-
-
-
- Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
- Melissa Haendel
- 9/18/11
- organism or virus or viroid
- organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical structure that has more than one cell as a part.
- djs93
- Sun Feb 27 10:53:00 GMT 2011
- CARO:0010000
-
- multicellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
-
-
-
-
-
-
-
-
-
- An individual member of a clade of cellular organisms.
-
- 7.16.2011
- CARO:0010004
- A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
- cellular organism
-
-
-
-
-
-
-
-
- Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them.
- Important for alignment with Darwin Core class "Organism".
- biological entity
-
-
-
-
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- chebi_ontology
- CHEBI:24431
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- ANON:ANON
-
-
-
-
-
-
-
- Any molecular entity that contains carbon.
- chebi_ontology
- organic compounds
- organic entity
- organic molecular entities
- CHEBI:50860
-
-
-
-
- Any molecular entity that contains carbon.
- ANON:ANON
-
-
-
-
- organic compounds
- ChEBI:
-
-
-
-
- organic entity
- ChEBI:
-
-
-
-
- organic molecular entities
- ChEBI:
-
-
-
-
@@ -8582,7 +8222,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
HSC
-
+
@@ -8705,7 +8345,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-M
-
+
@@ -8792,21 +8432,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -8892,13 +8532,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CLP
-
+
ELP
-
+
@@ -9022,7 +8662,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -9506,6 +9146,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
+
BTO:0002606
CALOHA:TS-0415
FBbt:00005144
@@ -9513,6 +9154,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neuroglial cell
neuroglia
+
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
glial cell
@@ -9598,20 +9240,20 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -9705,7 +9347,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
APC
-
+
@@ -9813,10 +9455,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -9965,7 +9605,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -10128,7 +9768,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CALOHA:TS-0868
FMA:86740
photoreceptor cell
- https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
+ https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
@@ -11110,7 +10750,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -11372,7 +11012,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -11381,7 +11021,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -11503,10 +11143,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -12039,8 +11677,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the monocyte, granulocyte, or mast cell lineage.
-
-
myeloid leukocyte
@@ -12162,13 +11798,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dendritic cell of the myeloid lineage.
-
interdigitating cell
veiled cell
BTO:0004721
CD11c+CD123- DC
mDC
-
These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
myeloid dendritic cell
@@ -12277,18 +11911,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Most markers only described for human pro NK cells.
pro-NK cell
-
-
-
- null cell
- PMID:11532393
-
-
-
-
- preNK cell
- PMID:11532393
-
@@ -12315,6 +11937,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PMID:15032583
PMID:15766674
+
+
+
+ null cell
+ PMID:11532393
+
+
+
+
+ preNK cell
+ PMID:11532393
+
@@ -13581,13 +13215,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -13774,8 +13406,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Any muscle cell in which the fibers are not organised into sarcomeres.
-
-
non-striated muscle cell
@@ -13902,7 +13532,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -15741,32 +15373,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -20292,8 +19924,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/geneontology/go-ontology/issues/21881
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
- biological condensate
cellular_component
+ biological condensate
GO:0043228
non-membrane-bounded organelle
@@ -21113,25 +20745,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
+ https://github.com/geneontology/go-ontology/issues/25943
Wikipedia:Organogenesis
development of an organ
organogenesis
@@ -21365,6 +20981,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
+ tissue remodelling
biological_process
GO:0048771
@@ -21945,9 +21562,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
+ https://github.com/geneontology/go-ontology/issues/24200
establishment of localisation
biological_process
GO:0051234
+
@@ -22592,24 +22211,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
mah
2010-03-08T03:32:18Z
@@ -23112,25 +22714,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -23144,12 +22727,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
uptake
biological_process
@@ -23592,14 +23169,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
+ https://github.com/geneontology/go-ontology/issues/24200
kmv
2019-08-12T18:01:37Z
cellular_component
GO:0110165
+
cellular anatomical entity
@@ -23778,25 +23356,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
@@ -24815,9 +24376,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
- trait
quality
PATO:0000001
quality
@@ -24828,12 +24387,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
PATOC:GVG
-
-
-
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
- PATOC:GVG
-
@@ -24929,28 +24482,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- quality
- PATO:0000125
-
-
-
- For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
- mass
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- PATOC:GVG
-
-
-
-
@@ -25121,7 +24652,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
- multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
@@ -25813,27 +25343,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
-
- 2014-12-12T08:41:11Z
- quality
- PATO:0010000
- What counts as maximally connected may be relative to some specification of granularity.
- maximally connected
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
- GOC:dos
-
-
-
-
@@ -28427,8 +27936,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -28479,11 +27988,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
tendon
http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg
-
+
-
+
@@ -28496,13 +28005,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
OG
-
+
AEO
@@ -28753,7 +28262,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -29493,7 +29001,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -29529,14 +29037,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
gastrula stage
-
+
-
+
BILS
@@ -29757,7 +29265,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -29830,7 +29338,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -29843,7 +29351,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -30152,7 +29660,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -30194,14 +29702,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -31433,7 +30941,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -31471,14 +30979,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -31531,7 +31039,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -31568,14 +31076,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -31620,7 +31128,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -31665,7 +31173,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -31678,7 +31186,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -31984,8 +31492,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -32021,24 +31529,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
eye
-
+
-
+
-
+
PMID:21062451
-
+
PMID:21062451
@@ -32650,7 +32158,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -32705,14 +32213,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -32800,7 +32308,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -32847,7 +32355,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
-
+
@@ -32861,7 +32369,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -33728,7 +33236,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Skeletal element that is composed of bone tissue.
@@ -33778,14 +33286,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -33896,7 +33404,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -33936,14 +33444,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -34534,7 +34042,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -34570,14 +34078,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
-
+
-
+
check ctenophore
@@ -34640,9 +34148,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
@@ -34697,15 +34205,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -34724,19 +34232,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -34821,8 +34329,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -34868,11 +34376,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -34885,13 +34393,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
GOTAX:0000352
-
+
ZFA
@@ -35068,12 +34576,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -35113,66 +34621,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -35527,7 +35035,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -35585,14 +35093,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
-
+
-
+
FMA
MA
@@ -35863,14 +35371,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
@@ -35914,24 +35422,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -36397,7 +35905,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -36422,14 +35930,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -36659,9 +36167,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -36693,34 +36201,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -36785,7 +36293,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -36814,7 +36322,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -36827,7 +36335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -36899,7 +36407,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -36943,7 +36451,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -36956,7 +36464,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
VHOG
@@ -37040,7 +36548,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -37083,7 +36591,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
myotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
@@ -37096,7 +36604,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2-abduced
@@ -37152,8 +36660,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -37180,11 +36688,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -37203,13 +36711,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
VHOG:0000680
-
+
ZFA
@@ -37418,7 +36926,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -37434,14 +36942,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -37769,7 +37277,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The bilaminar epithelium formed from the myotome and dermatome.
Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768].
Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]
@@ -37792,7 +37300,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004290
dermomyotome
-
+
@@ -37811,7 +37319,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
ZFA
@@ -38137,7 +37645,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
@@ -38151,7 +37659,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
-
+
@@ -38164,7 +37672,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
2012-08-14
VSAO:0000015
VSAO
@@ -38203,7 +37711,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -38219,14 +37727,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal element
-
+
-
+
VSAO
@@ -38271,7 +37779,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -38310,14 +37818,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -38784,7 +38292,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -38800,14 +38308,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -39104,7 +38612,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -39114,7 +38622,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -39133,7 +38641,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO-modified-relation
@@ -39238,7 +38746,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -39253,7 +38761,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochordal plate
-
+
@@ -39266,7 +38774,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
@@ -39303,7 +38811,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -39320,14 +38828,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -39785,7 +39293,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -39800,14 +39308,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -39897,7 +39405,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39914,14 +39422,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -40020,7 +39528,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40046,7 +39554,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive paraxial mesoderm
-
+
@@ -40062,7 +39570,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -40111,7 +39619,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -40119,7 +39627,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -40132,7 +39640,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -40442,7 +39950,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40459,14 +39967,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -40488,7 +39996,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -40496,14 +40004,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -40663,8 +40171,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -40677,11 +40185,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
subdivision of skeleton
-
+
-
+
@@ -40694,13 +40202,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
UBERONREF:0000003
-
+
VSAO
@@ -41071,7 +40579,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41096,7 +40604,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0011899
epimysium
-
+
@@ -41109,7 +40617,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
FMA
@@ -41215,7 +40723,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41237,7 +40745,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0012429
hematopoietic tissue
-
+
@@ -41250,7 +40758,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
defitional
@@ -41818,7 +41326,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41841,7 +41349,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0016887
entire extraembryonic component
-
+
@@ -41854,7 +41362,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -41940,7 +41448,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41956,14 +41464,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal musculature
-
+
-
+
MA
@@ -42462,27 +41970,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
///////////////////////////////////////////////////////////////////////////////////////
-->
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
@@ -42525,27 +42012,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Should belong in BFO, but lives in caro for now.
-
-
-
-
-
@@ -42566,16 +42032,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
@@ -43426,5 +42882,5 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
diff --git a/src/ontology/subsets/general_cell_types_upper_slim.tsv b/src/ontology/subsets/general_cell_types_upper_slim.tsv
index db206d0fb..482d60ba7 100644
--- a/src/ontology/subsets/general_cell_types_upper_slim.tsv
+++ b/src/ontology/subsets/general_cell_types_upper_slim.tsv
@@ -1,288 +1,279 @@
?x ?label
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1002
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1018
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1026
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1075
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1082
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1089
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1099
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1106
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1112
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1153
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1168
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1174
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid118
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1185
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1192
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1199
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1205
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid121
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1212
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1219
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1225
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1231
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1238
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1248
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1261
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1273
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1281
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1287
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1293
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1299
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1305
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1311
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1317
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1323
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1339
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1346
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1353
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1361
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1368
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1384
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1395
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1404
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1410
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1423
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1432
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1440
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1446
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1454
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1460
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1468
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1474
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1480
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1530
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1544
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1555
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1568
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1578
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1584
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1590
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1596
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1624
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1635
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1652
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1660
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1669
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1676
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1689
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1700
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1707
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1715
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1721
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1729
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1736
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1744
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1753
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1759
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1766
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1777
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1783
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1790
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1796
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1805
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1811
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1818
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1826
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1833
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1861
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1870
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1877
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1887
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1910
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1920
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1927
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1933
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1938
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1943
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1963
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1973
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1980
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1986
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1993
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2002
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2008
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2014
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2021
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2029
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2035
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2047
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2054
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2063
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2072
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2078
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2084
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2090
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2096
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2102
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2108
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2117
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2124
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2135
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2141
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2150
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2160
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2166
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2172
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2178
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2186
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2196
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2204
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2210
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2224
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2231
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2237
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2243
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2249
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2255
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2268
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2274
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2292
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2298
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2304
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2314
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2320
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2330
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2336
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2344
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2354
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2360
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2366
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2372
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2381
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2391
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2399
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2405
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2415
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2479
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2513
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2519
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2679
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2686
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2699
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2710
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2726
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2825
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2861
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2888
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2897
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2955
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2974
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2978
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2998
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3085
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3101
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3180
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3209
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3223
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3242
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3274
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3285
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3293
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid33
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid330
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid338
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3409
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3419
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3430
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid344
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3457
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3515
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid357
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3610
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3629
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid363
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3634
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3648
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3655
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3691
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid370
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3722
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3745
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3777
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3788
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3795
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3807
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3851
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3861
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3870
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3881
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3894
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3903
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3913
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3928
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3937
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3948
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3965
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3987
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4013
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4024
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4052
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4064
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4091
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4122
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4139
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4145
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4157
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4165
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid418
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4182
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid42
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4203
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4218
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4222
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4226
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4230
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4234
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4238
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid438
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid455
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid472
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid479
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid487
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid519
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid551
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid570
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid578
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid587
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid59
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid593
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid599
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid602
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid609
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid617
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid627
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid635
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid643
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid655
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid661
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid667
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid673
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid685
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid692
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid701
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid707
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid713
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid721
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid757
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid765
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid772
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid785
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid800
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid831
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid844
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid858
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid874
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid894
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid901
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid907
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid916
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid928
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid943
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid950
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid956
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid966
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1043
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1050
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1057
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1067
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1074
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1080
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid112
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1121
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1136
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1142
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid115
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1153
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1160
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1167
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1173
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1180
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1187
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1193
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1199
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1206
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1216
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1229
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1241
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1249
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1255
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1261
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1267
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1273
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1279
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1285
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1291
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1307
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1314
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1321
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1329
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1336
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1352
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1363
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1372
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1378
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1391
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1400
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1408
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1414
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1422
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1428
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1436
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1442
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1448
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1498
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1512
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1523
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1536
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1546
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1552
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1558
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1564
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1592
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1603
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1620
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1628
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1637
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1644
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1657
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1668
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1675
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1683
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1689
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1697
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1704
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1712
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1721
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1727
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1734
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1745
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1751
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1758
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1764
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1773
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1779
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1786
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1794
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1801
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1829
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1838
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1845
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1855
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1878
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1888
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1895
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1901
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1906
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1911
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1931
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1941
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1948
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1954
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1961
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1970
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1976
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1982
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1989
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1998
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2010
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2017
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2026
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2035
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2041
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2047
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2053
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2059
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2065
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2071
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2080
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2087
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2098
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2104
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2113
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2123
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2129
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2135
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2141
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2149
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2159
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2167
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2182
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2189
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2195
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2201
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2207
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2213
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2226
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2241
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2247
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2253
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2263
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2269
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2279
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2285
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2293
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2303
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2309
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2315
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2321
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2335
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2343
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2349
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2359
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2421
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2455
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2461
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2620
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2627
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2640
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2651
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2667
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2766
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2802
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2829
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2838
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2896
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2915
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2919
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2939
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3026
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3042
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid31
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3121
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3150
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3164
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3183
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3215
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3226
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3234
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid325
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid331
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3350
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3360
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3371
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid338
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3398
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3456
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3551
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3570
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3575
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3589
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3596
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3632
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3663
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3686
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3718
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3729
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3736
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3748
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3792
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3802
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3811
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3822
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3835
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3844
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3854
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid386
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3869
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3878
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3889
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid39
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3906
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3928
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3954
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3965
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3993
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4005
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4032
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid406
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4063
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4080
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4086
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4098
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4106
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4123
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4144
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4159
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4163
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4167
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4171
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid423
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid440
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid447
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid455
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid487
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid519
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid538
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid54
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid546
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid555
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid561
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid567
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid570
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid577
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid585
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid595
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid603
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid611
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid623
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid629
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid635
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid641
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid653
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid660
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid669
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid675
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid681
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid689
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid725
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid733
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid740
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid753
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid768
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid799
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid812
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid826
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid842
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid862
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid869
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid875
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid884
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid896
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid911
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid918
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid924
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid934
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid944
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid970
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid986
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid994
"continuant"
"occurrent"
"independent continuant"
@@ -290,17 +281,6 @@ _:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
"specifically dependent continuant"
"material entity"
"immaterial entity"
- "anatomical entity"
- "connected anatomical structure"
- "material anatomical entity"
- "multicellular organism"
- "gross anatomical part"
- "organism"
- "multicellular anatomical structure"
- "cellular organism"
- "biological entity"
-
-
"cell"
"neuronal receptor cell"
"early embryonic cell (metazoa)"
@@ -754,7 +734,6 @@ _:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
"qualitative"
"deviation (from_normal)"
"size"
- "mass"
"structure"
"circular"
"normal"
@@ -792,7 +771,6 @@ _:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
"superelliptic"
"transversely striated"
"nucleated"
- "maximally connected"
"disconnected"
"polymeric"
"anatomical structure quality"
diff --git a/subsets/blood_and_immune_upper_slim.json b/subsets/blood_and_immune_upper_slim.json
index 3339a4738..98bbc3116 100644
--- a/subsets/blood_and_immune_upper_slim.json
+++ b/subsets/blood_and_immune_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-09-21"
+ "val" : "2023-10-19"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-09-21/subsets/blood_and_immune_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-10-19/subsets/blood_and_immune_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -296,9 +296,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "occurs_in"
@@ -724,168 +721,6 @@
"val" : "in_dorsal_side_of"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "lbl" : "anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
- "xrefs" : [ "CAROC:Brownsville2014" ]
- },
- "comments" : [ "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "lbl" : "connected anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
- },
- "comments" : [ "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "lbl" : "material anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical entity that has mass."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "lbl" : "multicellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
- },
- "comments" : [ "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "lbl" : "gross anatomical part",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#plus" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "10.7.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "lbl" : "organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- },
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "organism or virus or viroid"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "Melissa Haendel"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "9/18/11"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "lbl" : "multicellular anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical structure that has more than one cell as a part."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "djs93"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "Sun Feb 27 10:53:00 GMT 2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "lbl" : "cellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An individual member of a clade of cellular organisms."
- },
- "comments" : [ "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. " ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "7.16.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "lbl" : "biological entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
- },
- "comments" : [ "Important for alignment with Darwin Core class \"Organism\"." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_50860",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any molecular entity that contains carbon.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "organic compounds",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic entity",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic molecular entities",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000000",
"lbl" : "cell",
@@ -970,7 +805,7 @@
"pred" : "hasExactSynonym",
"val" : "hemopoietic stem cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HSC"
}, {
@@ -1006,11 +841,11 @@
},
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BFU-E"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-E"
}, {
@@ -1041,7 +876,7 @@
},
"comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-M"
}, {
@@ -1101,17 +936,17 @@
"pred" : "hasExactSynonym",
"val" : "common myeloid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GEMM",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-S",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CMP",
"xrefs" : [ "ISBN:0878932437" ]
@@ -1199,11 +1034,11 @@
"pred" : "hasExactSynonym",
"val" : "common lymphoid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CLP"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "ELP"
}, {
@@ -1342,7 +1177,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"
} ]
}
@@ -1601,15 +1436,15 @@
"val" : "marrow stromal cells",
"xrefs" : [ "PMID:11378515" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BMSC"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-F"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "MSC",
"xrefs" : [ "PMID:11378515" ]
@@ -1661,7 +1496,7 @@
"comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ],
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "APC"
} ]
@@ -1675,15 +1510,10 @@
"val" : "A cell that specializes in controlled release of one or more substances.",
"xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "BTO:0003659"
}, {
"val" : "FMA:86916"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1726,7 +1556,7 @@
"val" : "WBbt:0003675"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg"
} ]
}
@@ -2218,7 +2048,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg"
} ]
}
@@ -2495,12 +2325,12 @@
"pred" : "hasExactSynonym",
"val" : "granulocyte/monocyte progenitor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GM",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "GMP",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
@@ -2559,17 +2389,12 @@
"xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
},
"comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "angioblast"
}, {
"pred" : "hasExactSynonym",
"val" : "chondroplast"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -2786,12 +2611,7 @@
"definition" : {
"val" : "A cell of the monocyte, granulocyte, or mast cell lineage.",
"xrefs" : [ "GOC:add" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000767",
@@ -2944,7 +2764,6 @@
"xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ]
},
"comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasBroadSynonym",
"val" : "interdigitating cell"
@@ -2960,10 +2779,6 @@
} ],
"xrefs" : [ {
"val" : "BTO:0004721"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -3120,7 +2935,7 @@
"pred" : "hasExactSynonym",
"val" : "gammadelta T cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "gd T cell"
} ],
@@ -4023,7 +3838,6 @@
"val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.",
"xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "CALOHA:TS-2096"
}, {
@@ -4032,9 +3846,6 @@
"val" : "MESH:D003239"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- }, {
"pred" : "http://purl.org/dc/terms/contributor",
"val" : "https://orcid.org/0000-0003-1980-3228"
}, {
@@ -4220,9 +4031,14 @@
"definition" : {
"val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
},
+ "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "mesenchyme cell"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -11531,7 +11347,7 @@
"pred" : "hasExactSynonym",
"val" : "non-membrane-enclosed organelle"
}, {
- "pred" : "hasNarrowSynonym",
+ "pred" : "hasRelatedSynonym",
"val" : "biological condensate"
} ],
"xrefs" : [ {
@@ -12231,6 +12047,9 @@
"val" : "Wikipedia:Organogenesis"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/25943"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -12535,6 +12354,10 @@
"xrefs" : [ "GOC:ebc" ]
},
"subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "synonyms" : [ {
+ "pred" : "hasExactSynonym",
+ "val" : "tissue remodelling"
+ } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
@@ -13023,13 +12846,16 @@
"val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.",
"xrefs" : [ "GOC:ai", "GOC:dos" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "establishment of localisation",
"xrefs" : [ "GOC:mah" ]
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -14462,8 +14288,11 @@
"val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
"xrefs" : [ "GOC:kmv" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
"val" : "kmv"
}, {
@@ -15011,7 +14840,7 @@
"val" : "http://purl.obolibrary.org/obo/IAO_0000122"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
- "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "PERSON:Daniel Schober"
@@ -16217,6 +16046,28 @@
"val" : "https://orcid.org/0000-0002-8688-6599"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/OMO_0003000",
+ "lbl" : "abbreviation",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A synonym type for describing abbreviations or initalisms"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/information-artifact-ontology/ontology-metadata/issues/122"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-4423-4370"
+ }, {
+ "pred" : "http://purl.org/dc/terms/created",
+ "val" : "2023-03-03"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/OMO_0003004",
"lbl" : "plural form",
@@ -16245,13 +16096,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.",
+ "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities",
"xrefs" : [ "PATOC:GVG" ]
},
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "trait"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
"val" : "PATO:0000072"
@@ -16339,22 +16186,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "lbl" : "mass",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.",
- "xrefs" : [ "PATOC:GVG" ]
- },
- "comments" : [ "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/pato#attribute_slim", "http://purl.obolibrary.org/obo/pato#relational_slim", "http://purl.obolibrary.org/obo/pato#scalar_slim" ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0000141",
"lbl" : "structure",
@@ -16574,9 +16405,6 @@
}, {
"pred" : "hasExactSynonym",
"val" : "multiply inhering quality of a physical entity"
- }, {
- "pred" : "hasExactSynonym",
- "val" : "multiply inhering quality of a physical entity "
}, {
"pred" : "hasExactSynonym",
"val" : "quality of a continuant"
@@ -17331,27 +17159,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "lbl" : "maximally connected",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.",
- "xrefs" : [ "GOC:dos" ]
- },
- "comments" : [ "What counts as maximally connected may be relative to some specification of granularity." ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-7073-9172"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
- "val" : "2014-12-12T08:41:11Z"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0010001",
"lbl" : "disconnected",
@@ -21063,7 +20870,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002000",
- "lbl" : "boundary_of",
+ "lbl" : "2D boundary of",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -21100,7 +20907,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002002",
- "lbl" : "has_boundary",
+ "lbl" : "has 2D boundary",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -21499,12 +21306,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a neuron and a material anatomical entity that its soma is part of."
},
- "xrefs" : [ {
- "val" : "RO:0002100"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21514,15 +21317,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some (\n and some ?Y)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21533,9 +21330,6 @@
"definition" : {
"val" : "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"
},
- "xrefs" : [ {
- "val" : "RO:0002101"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21554,9 +21348,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21593,8 +21384,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between an anatomical structure and a neuron that chemically synapses to it.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "
},
"xrefs" : [ {
"val" : "RO:0002103"
@@ -21611,18 +21401,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that has_part some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -21673,10 +21457,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "
},
- "comments" : [ "Relation between a neuron and the structure in which its dendrite receives synapses." ],
- "xrefs" : [ {
- "val" : "RO:0002110"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21689,9 +21469,6 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "synapsed in"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))"
@@ -21701,9 +21478,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21714,9 +21488,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."
},
- "xrefs" : [ {
- "val" : "RO:0002113"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21726,18 +21497,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21746,13 +21511,9 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that it chemically synapses to.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n "
},
"comments" : [ "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ],
- "xrefs" : [ {
- "val" : "RO:0002120"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21765,18 +21526,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21785,13 +21540,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
},
- "comments" : [ "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)" ],
- "xrefs" : [ {
- "val" : "RO:0002130"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -21804,18 +21554,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -21884,8 +21628,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."
},
"xrefs" : [ {
"val" : "RO:0002134"
@@ -21899,18 +21642,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that ( some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -22535,9 +22272,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "regulates"
@@ -22570,9 +22304,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "negatively_regulates"
@@ -22605,9 +22336,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "positively_regulates"
@@ -26273,6 +26001,47 @@
"val" : "https://orcid.org/0000-0003-4639-4431"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "lbl" : "has small molecule regulator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:27:26Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "lbl" : "has small molecule activator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
+ },
+ "xrefs" : [ {
+ "val" : "RO:0012001"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:28:37Z"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
+ "val" : "external"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
+ "val" : "has_small_molecule_activator"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012003",
"lbl" : "acts on population of",
@@ -26299,6 +26068,41 @@
"val" : "acts_on_population_of"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "lbl" : "is small molecule regulator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:17Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "lbl" : "is small molecule activator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:26Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_small_molecule_activator_of"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012008",
"lbl" : "results in fusion of",
@@ -36744,19 +36548,6 @@
"val" : "uberon"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/cl#abbreviation",
- "lbl" : "abbreviation",
- "type" : "PROPERTY",
- "meta" : {
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/elements/1.1/date",
- "val" : "2022-03-29T15:09:49Z"
- }, {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-1773-2692"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim",
"lbl" : "blood_and_immune_upper_slim",
@@ -37319,25 +37110,6 @@
"val" : "seeAlso"
} ]
}
- }, {
- "id" : "http://xmlns.com/foaf/0.1/depicted_by",
- "lbl" : "depicted by",
- "type" : "PROPERTY",
- "meta" : {
- "xrefs" : [ {
- "val" : "http://xmlns.com/foaf/0.1/depicted_by"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "uberon"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag",
- "val" : "true"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
- "val" : "depicted_by"
- } ]
- }
} ],
"edges" : [ {
"sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
@@ -37359,74 +37131,6 @@
"sub" : "http://purl.obolibrary.org/obo/BFO_0000141",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0030000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0010000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000125"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000012"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001008"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001993"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001010"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000000",
"pred" : "is_a",
@@ -42451,10 +42155,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0042221",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0050896"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0042221",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002233",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0042246",
"pred" : "is_a",
@@ -42839,10 +42539,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0048513",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0048856"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0048513",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002296",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0048518",
"pred" : "is_a",
@@ -43399,10 +43095,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0071704",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0008152"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0071704",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004007",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0071707",
"pred" : "is_a",
@@ -43579,10 +43271,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0098657",
"pred" : "http://purl.obolibrary.org/obo/RO_0002339",
"obj" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0098657",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0098793",
"pred" : "is_a",
@@ -43691,10 +43379,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0099537",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0099536"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0110165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0110165",
"pred" : "is_a",
@@ -43775,10 +43459,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_1901576",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0071704"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_1901576",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004008",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_1902105",
"pred" : "is_a",
@@ -44019,10 +43699,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0000117",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001018"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0000141",
"pred" : "is_a",
@@ -44235,10 +43911,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0002505",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0001404"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000141"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0010001",
"pred" : "is_a",
@@ -44667,10 +44339,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002497",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
"pred" : "is_a",
@@ -49147,10 +48815,30 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0011002",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012000"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012003",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002596"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002598"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012008",
"pred" : "subPropertyOf",
@@ -49455,36 +49143,20 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0003000",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012005"
}, {
"sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to"
} ],
"logicalDefinitionAxioms" : [ {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010000"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0000125"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001993"
- } ]
- }, {
"definedClassId" : "http://purl.obolibrary.org/obo/CL_0000034",
"genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ],
"restrictions" : [ {
@@ -51733,13 +51405,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002233",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000236"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042221",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002233",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0042246",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0031099" ],
@@ -51887,13 +51552,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000000"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048513",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
- "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0048518",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -52174,13 +51832,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002588",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0043226"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071704",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0071826",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ],
@@ -52244,19 +51895,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005604"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098657",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002338",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0098796",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ],
@@ -52370,13 +52008,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901576",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_1902105",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -53156,7 +52787,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002002",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040", "http://purl.obolibrary.org/obo/CARO_0000003" ],
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
diff --git a/subsets/blood_and_immune_upper_slim.obo b/subsets/blood_and_immune_upper_slim.obo
index 999f7eb2e..d86db0c8b 100644
--- a/subsets/blood_and_immune_upper_slim.obo
+++ b/subsets/blood_and_immune_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-09-21/subsets/blood_and_immune_upper_slim.owl
+data-version: cl/releases/2023-10-19/subsets/blood_and_immune_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,13 +82,12 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/blood_and_immune_upper_slim
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -147,106 +138,6 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:24431
-namespace: chebi_ontology
-def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [ANON:ANON]
-is_a: BFO:0000040 ! material entity
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -301,7 +192,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -347,10 +238,10 @@ id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
-synonym: "BFU-E" RELATED abbreviation []
+synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
-synonym: "CFU-E" RELATED abbreviation []
+synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
@@ -363,7 +254,7 @@ id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
-synonym: "CFU-M" RELATED abbreviation []
+synonym: "CFU-M" RELATED OMO:0003000 []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
@@ -405,9 +296,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -451,13 +342,13 @@ name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: human_reference_atlas
-synonym: "CLP" RELATED abbreviation []
+synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
-synonym: "ELP" RELATED abbreviation []
+synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
@@ -530,7 +421,7 @@ is_a: CL:0000000 ! cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000071
@@ -736,9 +627,9 @@ id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -746,7 +637,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -761,7 +652,7 @@ name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
-synonym: "APC" RELATED abbreviation []
+synonym: "APC" RELATED OMO:0003000 []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
@@ -771,14 +662,12 @@ relationship: capable_of GO:0002504 ! antigen processing and presentation of pep
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000183
@@ -801,7 +690,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -1154,7 +1043,7 @@ is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000542
@@ -1365,9 +1254,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: human_reference_atlas
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
-synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
-synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
@@ -1458,7 +1347,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -1469,7 +1357,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -1657,12 +1544,10 @@ relationship: has_part GO:0005634 ! nucleus
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
-subset: human_reference_atlas
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000767
@@ -1758,7 +1643,6 @@ id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
-subset: human_reference_atlas
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
@@ -1771,7 +1655,6 @@ intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleuki
intersection_of: develops_from CL:0000763 ! myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000763 ! myeloid cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000784
@@ -1874,7 +1757,7 @@ synonym: "gamma-delta T lymphocyte" EXACT []
synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
-synonym: "gd T cell" RELATED abbreviation []
+synonym: "gd T cell" RELATED OMO:0003000 []
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
@@ -2608,7 +2491,6 @@ creation_date: 2010-09-15T01:34:57Z
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -2617,7 +2499,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -2733,10 +2614,12 @@ is_a: CL:0000988 ! hematopoietic cell
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0010017
@@ -6500,9 +6383,6 @@ subset: goslim_yeast
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus
-intersection_of: GO:0050896 ! response to stimulus
-intersection_of: has_input CHEBI:24431
-relationship: has_input CHEBI:24431
[Term]
id: GO:0042246
@@ -6685,7 +6565,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -7076,9 +6956,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048518
@@ -7253,6 +7131,7 @@ name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
+synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process
[Term]
@@ -7538,12 +7417,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051239
@@ -7931,9 +7812,6 @@ synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:50860
-relationship: has_primary_input_or_output CHEBI:50860
created_by: mah
creation_date: 2010-03-08T03:32:18Z
@@ -8210,11 +8088,6 @@ namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport
-intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:24431
-intersection_of: has_target_end_location GO:0005737 ! cytoplasm
-intersection_of: has_target_start_location GO:0005576 ! extracellular region
-relationship: has_primary_input CHEBI:24431
relationship: has_target_end_location GO:0005737 ! cytoplasm
relationship: has_target_start_location GO:0005576 ! extracellular region
@@ -8353,10 +8226,11 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -8473,9 +8347,6 @@ synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:50860
-relationship: has_primary_output CHEBI:50860
created_by: pr
creation_date: 2012-11-05T11:04:40Z
@@ -8939,8 +8810,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -8986,17 +8855,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000141
name: structure
@@ -9109,7 +8967,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -9501,16 +9358,6 @@ is_a: PATO:0001404 ! nucleate quality
relationship: dc-contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -10952,7 +10799,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological_process
@@ -11233,7 +11079,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -11385,7 +11231,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -11478,7 +11324,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -11938,7 +11784,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -11969,7 +11815,7 @@ is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: has_part CL:0000076 ! squamous epithelial cell
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"}
[Term]
@@ -12067,7 +11913,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -12142,7 +11988,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -12182,8 +12028,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -12229,7 +12075,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -12268,7 +12114,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -12436,7 +12282,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -12518,7 +12364,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073
relationship: never_in_taxon NCBITaxon:6157
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -12559,7 +12405,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -12615,8 +12461,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -12740,7 +12586,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -13038,7 +12884,7 @@ relationship: has_part CL:0000071 {source="AEO"} ! blood vessel endothelial cell
relationship: has_part UBERON:0007500 {source="EHDAA2"} ! epithelial tube open at both ends
relationship: has_quality PATO:0002045 ! dendritic
relationship: part_of UBERON:0004537 ! blood vasculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011004", ontology="AAO", source="AAO:EJS"}
@@ -13093,7 +12939,7 @@ relationship: composed_primarily_of UBERON:0000055 ! vessel
relationship: has_part UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0007798 ! vascular system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "see also: vascular system. Consider merging?" xsd:string
property_value: UBPROP:0000007 "vascular" xsd:string
@@ -13325,8 +13171,8 @@ intersection_of: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0002323 ! coelemic cavity lumen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" xsd:string
[Term]
@@ -13412,7 +13258,7 @@ relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -13461,7 +13307,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -13510,8 +13356,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -13601,7 +13447,7 @@ relationship: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0002390 {source="FMA", source="MA"} ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string
property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string
property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"}
@@ -13813,7 +13659,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -13920,7 +13766,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -13957,7 +13803,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -13991,7 +13837,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -14029,7 +13875,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -14086,7 +13932,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -14146,7 +13992,7 @@ intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -14971,7 +14817,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -16115,7 +15961,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -16127,7 +15972,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -16231,10 +16076,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -16243,15 +16085,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -16295,10 +16133,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -16309,15 +16144,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -16325,34 +16157,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -16361,7 +16184,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -16530,7 +16352,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -16581,7 +16403,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -16789,7 +16611,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -16879,7 +16701,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -17136,6 +16958,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -17267,7 +17116,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -17315,7 +17164,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -17393,7 +17242,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -17636,13 +17485,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -17977,7 +17819,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -17989,7 +17830,6 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
is_a: RO:0002323 ! mereotopologically related to
@@ -18115,7 +17955,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -18305,12 +18145,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -18554,17 +18405,14 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -18607,8 +18455,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -18664,7 +18512,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -18713,7 +18560,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -18773,7 +18619,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -18847,7 +18693,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19033,7 +18878,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19423,10 +19267,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -19435,7 +19277,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/subsets/blood_and_immune_upper_slim.owl b/subsets/blood_and_immune_upper_slim.owl
index 4c19bb7a1..b217aab43 100644
--- a/subsets/blood_and_immune_upper_slim.owl
+++ b/subsets/blood_and_immune_upper_slim.owl
@@ -10,10 +10,8 @@
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
- xmlns:caro="http://purl.obolibrary.org/obo/caro#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
- xmlns:fbbt="http://purl.obolibrary.org/obo/fbbt#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo2="http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/"
xmlns:pato="http://purl.obolibrary.org/obo/pato#"
@@ -31,8 +29,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-09-21
+
+ 2023-10-19
@@ -99,7 +97,7 @@ We don't have definitions of 'meaning' or 'expression'
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
@@ -273,18 +271,6 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
-
-
-
-
-
-
-
-
-
-
-
-
@@ -315,6 +301,19 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
+
+
+
+ CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
+ A synonym type for describing abbreviations or initalisms
+
+
+ 2023-03-03
+ abbreviation
+
+
+
+
@@ -675,22 +674,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -699,17 +682,6 @@ WHERE {
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -749,46 +721,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1043,14 +975,6 @@ WHERE {
-
-
-
-
-
-
-
-
@@ -1547,12 +1471,6 @@ WHERE {
-
-
-
-
-
-
@@ -2016,14 +1934,7 @@ WHERE {
-
- http://xmlns.com/foaf/0.1/depicted_by
- uberon
- depicted_by
- true
- depicted_by
- depicted by
-
+
@@ -2222,7 +2133,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
unfolds_in
BFO:0000066
external
- gene_ontology
occurs_in
@@ -2917,7 +2827,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
surface of
2D boundary of
- boundary_of
@@ -2927,7 +2836,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
-
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
@@ -2943,7 +2851,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
has_boundary
has 2D boundary
has 2D boundary
- has_boundary
@@ -3280,23 +3187,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and a material anatomical entity that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
- BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)
- RO:0002100
- fly_anatomy.ontology
- has_soma_location
has soma location
-
-
-
- Relation between a neuron and an anatomical structure that its soma is part of.
-
-
@@ -3307,7 +3203,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3334,17 +3229,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
))))))
- RO:0002101
- fly_anatomy.ontology
- fasciculates_with
fasciculates with
-
-
-
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
-
-
@@ -3390,27 +3276,18 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
- Relation between an anatomical structure and a neuron that chemically synapses to it.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))
RO:0002103
- fly_anatomy.ontology
uberon
synapsed_by
synapsed_by
synapsed by
synapsed by
-
-
-
- Relation between an anatomical structure and a neuron that chemically synapses to it.
-
-
@@ -3449,16 +3326,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
synapsed in
- BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))
http://purl.obolibrary.org/obo/BFO_0000051 some (
http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (
http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))
- RO:0002110
- fly_anatomy.ontology
- has_postsynaptic_terminals_in
- Relation between a neuron and the structure in which its dendrite receives synapses.
has postsynaptic terminal in
@@ -3477,12 +3349,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
synapses in
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))
- RO:0002113
- fly_anatomy.ontology
- has_presynaptic_terminals_in
has presynaptic terminal in
@@ -3506,16 +3374,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
- Relation between a neuron and an anatomical structure that it chemically synapses to.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))
- RO:0002120
- fly_anatomy.ontology
- synapsed_to
N1 synapsed_to some N2
Expands to:
N1 SubclassOf (
@@ -3525,12 +3388,6 @@ N1 SubclassOf (
‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
-
-
-
- Relation between a neuron and an anatomical structure that it chemically synapses to.
-
-
@@ -3545,25 +3402,13 @@ N1 SubclassOf (
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synapse in
<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)
- RO:0002130
- fly_anatomy.ontology
- has_synaptic_terminals_in
- expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
has synaptic terminal in
-
-
-
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
-
-
@@ -3675,26 +3520,17 @@ N1 SubclassOf (
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))
RO:0002134
- fly_anatomy.ontology
uberon
innervates
innervates
innervates
innervates
-
-
-
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
@@ -4174,7 +4010,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.false
RO:0002211
external
- gene_ontology
regulates
@@ -4203,7 +4038,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002212
external
- gene_ontology
negatively_regulates
@@ -4237,7 +4071,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002213
external
- gene_ontology
positively_regulates
@@ -7254,6 +7087,37 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is regulated by the small molecule continuant
+
+ 2020-04-22T20:27:26Z
+ has small molecule regulator
+
+
+
+
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is activated by the small molecule continuant
+
+ 2020-04-22T20:28:37Z
+ RO:0012001
+ external
+ has_small_molecule_activator
+ has_small_molecule_activator
+ has small molecule activator
+ has small molecule activator
+
+
+
+
@@ -7274,6 +7138,32 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process
+
+ 2020-06-24T13:15:17Z
+ is small molecule regulator of
+
+
+
+
+
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that activates the process
+
+ 2020-06-24T13:15:26Z
+ is small molecule activator of
+ https://wiki.geneontology.org/Is_small_molecule_activator_of
+
+
+
+
@@ -8031,256 +7921,6 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CARO:0000000
- Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
- anatomical entity
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CAROC:Brownsville2014
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
- CARO:0000003
-
- Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
- connected anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical entity that has mass.
- CARO:0000006
-
- material anatomical entity
-
-
-
-
-
-
-
-
- Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell.
- CARO:0000012
- MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-
-MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
- multicellular organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
-
- 10.7.2011
-
- gross anatomical part
-
-
-
-
-
-
-
-
- Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
- Melissa Haendel
- 9/18/11
- organism or virus or viroid
- organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical structure that has more than one cell as a part.
- djs93
- Sun Feb 27 10:53:00 GMT 2011
- CARO:0010000
-
- multicellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
-
-
-
-
-
-
-
-
-
- An individual member of a clade of cellular organisms.
-
- 7.16.2011
- CARO:0010004
- A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
- cellular organism
-
-
-
-
-
-
-
-
- Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them.
- Important for alignment with Darwin Core class "Organism".
- biological entity
-
-
-
-
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- chebi_ontology
- CHEBI:24431
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- ANON:ANON
-
-
-
-
-
-
-
- Any molecular entity that contains carbon.
- chebi_ontology
- organic compounds
- organic entity
- organic molecular entities
- CHEBI:50860
-
-
-
-
- Any molecular entity that contains carbon.
- ANON:ANON
-
-
-
-
- organic compounds
- ChEBI:
-
-
-
-
- organic entity
- ChEBI:
-
-
-
-
- organic molecular entities
- ChEBI:
-
-
-
-
@@ -8564,7 +8204,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
HSC
-
+
@@ -8608,13 +8248,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BFU-E
-
+
CFU-E
-
+
@@ -8711,7 +8351,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-M
-
+
@@ -8799,21 +8439,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -8967,13 +8607,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CLP
-
+
ELP
-
+
@@ -9097,7 +8737,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -9870,20 +9510,20 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -9946,7 +9586,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
APC
-
+
@@ -9973,10 +9613,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -10026,7 +9664,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -11023,7 +10661,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -12012,7 +11650,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -12021,7 +11659,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -12181,12 +11819,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
reticulocyte
-
-
-
-
- true
-
@@ -12196,6 +11828,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PMID:15946868
PMID:2037622
+
+
+
+
+ true
+
@@ -12316,10 +11954,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -13000,8 +12636,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the monocyte, granulocyte, or mast cell lineage.
-
-
myeloid leukocyte
@@ -13323,13 +12957,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dendritic cell of the myeloid lineage.
-
interdigitating cell
veiled cell
BTO:0004721
CD11c+CD123- DC
mDC
-
These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
myeloid dendritic cell
@@ -13693,7 +13325,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
gd T cell
-
+
@@ -16281,13 +15913,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -16649,7 +16279,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -20300,32 +19932,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -26517,24 +26149,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
response to chemical stimulus
response to chemical substance
@@ -27031,8 +26646,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/geneontology/go-ontology/issues/21881
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
- biological condensate
cellular_component
+ biological condensate
GO:0043228
non-membrane-bounded organelle
@@ -28097,25 +27712,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
+ https://github.com/geneontology/go-ontology/issues/25943
Wikipedia:Organogenesis
development of an organ
organogenesis
@@ -28625,6 +28224,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
+ tissue remodelling
biological_process
GO:0048771
@@ -29387,9 +28987,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
+ https://github.com/geneontology/go-ontology/issues/24200
establishment of localisation
biological_process
GO:0051234
+
@@ -30437,24 +30039,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
mah
2010-03-08T03:32:18Z
@@ -31238,25 +30823,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -31270,12 +30836,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
uptake
biological_process
@@ -31713,14 +31273,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
+ https://github.com/geneontology/go-ontology/issues/24200
kmv
2019-08-12T18:01:37Z
cellular_component
GO:0110165
+
cellular anatomical entity
@@ -32006,25 +31567,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
@@ -33274,9 +32818,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
- trait
quality
PATO:0000001
quality
@@ -33287,12 +32829,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
PATOC:GVG
-
-
-
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
- PATOC:GVG
-
@@ -33388,28 +32924,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- quality
- PATO:0000125
-
-
-
- For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
- mass
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- PATOC:GVG
-
-
-
-
@@ -33623,7 +33137,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
- multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
@@ -34479,27 +33992,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
-
- 2014-12-12T08:41:11Z
- quality
- PATO:0010000
- What counts as maximally connected may be relative to some specification of granularity.
- maximally connected
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
- GOC:dos
-
-
-
-
@@ -38163,7 +37655,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38845,7 +38336,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -38881,14 +38372,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
gastrula stage
-
+
-
+
BILS
@@ -39109,7 +38600,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39182,7 +38673,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -39195,7 +38686,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -39320,15 +38811,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -39370,34 +38861,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
-
+
Bgee:AN
@@ -39701,7 +39192,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39743,14 +39234,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -40980,7 +40471,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -41018,14 +40509,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -41078,7 +40569,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -41115,14 +40606,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -41167,7 +40658,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -41212,7 +40703,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -41225,7 +40716,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -41432,7 +40923,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41509,14 +41000,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb
-
+
-
+
MA
@@ -42177,7 +41668,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -42230,14 +41721,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -42325,7 +41816,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -42372,7 +41863,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
-
+
@@ -42386,7 +41877,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -42880,7 +42371,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Skeletal element that is composed of bone tissue.
@@ -42930,14 +42421,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -43048,7 +42539,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -43088,14 +42579,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -43372,8 +42863,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -43386,7 +42877,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -43443,34 +42934,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
-
+
-
+
-
+
-
+
AEO
-
+
EHDAA2
-
+
GO:0072360
@@ -44193,7 +43684,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -44227,14 +43718,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
-
+
-
+
check ctenophore
@@ -44363,7 +43854,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -44404,14 +43895,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
coelemic cavity lumen
-
+
-
+
definitional
@@ -44519,9 +44010,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
@@ -44576,15 +44067,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -44603,19 +44094,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -44700,8 +44191,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -44747,11 +44238,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -44764,13 +44255,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
GOTAX:0000352
-
+
ZFA
@@ -44883,12 +44374,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -44928,66 +44419,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -45175,7 +44666,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -45233,14 +44724,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
-
+
-
+
FMA
MA
@@ -45511,14 +45002,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -45561,24 +45052,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -45949,7 +45440,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -45974,14 +45465,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -46211,9 +45702,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -46245,34 +45736,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -46337,7 +45828,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -46366,7 +45857,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -46379,7 +45870,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -46451,7 +45942,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -46495,7 +45986,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -46508,7 +45999,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
VHOG
@@ -46592,15 +46083,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
-
+
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
@@ -46620,15 +46111,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
heart primordium
-
+
-
+
-
+
@@ -46641,19 +46132,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
ZFA
-
+
ZFA
-
+
XAO
@@ -46708,8 +46199,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -46736,11 +46227,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -46759,13 +46250,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
VHOG:0000680
-
+
ZFA
@@ -47031,7 +46522,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -47047,14 +46538,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -47373,8 +46864,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
@@ -47387,24 +46878,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004140
primary heart field
-
+
-
+
-
+
GO:0003128
-
+
https://orcid.org/0000-0003-3308-6245
@@ -47463,7 +46954,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
@@ -47483,14 +46974,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
heart tube
-
+
-
+
ZFA-modified
@@ -48107,7 +47598,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
@@ -48121,7 +47612,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
-
+
@@ -48134,7 +47625,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
2012-08-14
VSAO:0000015
VSAO
@@ -48173,7 +47664,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -48189,14 +47680,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal element
-
+
-
+
VSAO
@@ -48241,7 +47732,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -48280,14 +47771,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -49045,7 +48536,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -49061,14 +48552,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -49179,7 +48670,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
@@ -49197,14 +48688,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
primitive heart tube
-
+
-
+
ZFA
@@ -49372,7 +48863,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -49382,7 +48873,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -49401,7 +48892,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO-modified-relation
@@ -49506,7 +48997,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -49521,7 +49012,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochordal plate
-
+
@@ -49534,7 +49025,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
@@ -49571,7 +49062,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -49588,14 +49079,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -50338,7 +49829,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -50353,14 +49844,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -50450,7 +49941,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50467,14 +49958,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -50573,7 +50064,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50599,7 +50090,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive paraxial mesoderm
-
+
@@ -50615,7 +50106,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -50691,7 +50182,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -50699,7 +50190,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -50712,7 +50203,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -50809,7 +50300,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Anatomical system that consists of all blood and lymph vessels.
consider merging with vasculature
The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
@@ -50826,14 +50317,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
vascular system
-
+
-
+
MA
@@ -50966,7 +50457,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50983,14 +50474,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -51046,7 +50537,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -51054,14 +50545,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -51083,7 +50574,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EFO:0003704
TAO:0005041
ZFA:0005041
@@ -51093,14 +50584,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
anterior lateral plate mesoderm
-
+
-
+
ZFA
@@ -51234,7 +50725,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -51254,14 +50745,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0010210
blood clot
-
+
-
+
BTO
@@ -51383,8 +50874,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -51397,11 +50888,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
subdivision of skeleton
-
+
-
+
@@ -51414,13 +50905,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
UBERONREF:0000003
-
+
VSAO
@@ -51497,7 +50988,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
axial skeletal system
FMA:302077
@@ -51507,7 +50998,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
postcranial axial skeletal system
http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton
-
+
@@ -51520,7 +51011,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
cjm
@@ -51785,7 +51276,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -51807,7 +51298,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0012429
hematopoietic tissue
-
+
@@ -51820,7 +51311,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
defitional
@@ -52390,7 +51881,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -52413,7 +51904,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0016887
entire extraembryonic component
-
+
@@ -52426,7 +51917,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -52862,27 +52353,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
///////////////////////////////////////////////////////////////////////////////////////
-->
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
@@ -52949,27 +52419,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Should belong in BFO, but lives in caro for now.
-
-
-
-
-
@@ -53000,16 +52449,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
@@ -53999,5 +53438,5 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase
-
+
diff --git a/subsets/blood_and_immune_upper_slim.tsv b/subsets/blood_and_immune_upper_slim.tsv
index ad1a82d10..6f047699e 100644
--- a/subsets/blood_and_immune_upper_slim.tsv
+++ b/subsets/blood_and_immune_upper_slim.tsv
@@ -1,405 +1,395 @@
?x ?label
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1038
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1051
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1065
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1081
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1099
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1106
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1112
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1124
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1134
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1142
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid118
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1189
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1195
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid121
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1214
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1233
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1243
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1253
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1260
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1273
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1296
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1303
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1311
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1328
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1338
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1359
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1375
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1383
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1393
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1470
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1519
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1526
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1533
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1539
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1558
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1565
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1584
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1597
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1617
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1624
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1630
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1671
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1686
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1698
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1707
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1718
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1746
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1753
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1760
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1766
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1772
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1779
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1787
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1794
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1801
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1807
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1813
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1819
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1826
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1833
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1840
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1883
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1889
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1898
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1904
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1910
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1916
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1922
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1929
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1937
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1943
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1948
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1956
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1969
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1976
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1983
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1990
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid1998
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2007
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2026
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2037
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2051
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2064
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2070
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2077
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2083
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2089
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2095
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2103
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2111
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2122
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2130
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2136
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2148
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2154
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2168
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2174
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2180
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2186
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2192
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2198
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2204
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2210
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2216
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2222
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2228
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2234
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2240
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2246
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2252
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2258
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2264
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2270
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2276
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2284
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2290
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2298
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2386
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2400
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2415
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2431
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2447
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2460
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2470
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2476
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2482
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2488
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2496
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2517
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2528
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2539
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2549
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2559
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2568
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2576
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2589
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2600
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2606
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2616
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2624
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2630
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2636
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2642
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2652
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2661
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2668
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2676
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2684
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2690
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2697
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2708
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2714
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2723
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2730
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2740
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2746
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2752
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2758
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2774
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2780
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2786
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2792
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2797
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2804
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2813
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2820
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2832
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2842
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2848
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2859
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2875
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2885
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2894
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2901
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2916
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2924
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2939
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2945
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2951
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2958
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2968
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2986
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid2996
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3003
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3009
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3015
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3020
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3025
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3031
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3037
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3063
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3073
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3080
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3086
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3093
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3101
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3107
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3113
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3119
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3126
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3134
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3140
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3146
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3152
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3158
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3164
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3170
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3176
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3188
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3195
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3202
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3210
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3221
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3227
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3233
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3239
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3245
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3251
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3258
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3264
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3270
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3280
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3288
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3294
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid33
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3305
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid331
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3311
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3317
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3323
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3334
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3343
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3349
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3356
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3362
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3368
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3374
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3382
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid339
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3392
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3399
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3404
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3416
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3423
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3429
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3445
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid345
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3458
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3466
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3473
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3479
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3491
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3498
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3504
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3516
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3522
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3540
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3546
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3552
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3559
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3569
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3575
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3585
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid359
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3591
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3601
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3607
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3614
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3620
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3625
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3632
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3641
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3651
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3659
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid366
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3665
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3671
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3677
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3688
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3694
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3703
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3772
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3815
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid3821
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4057
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4064
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4073
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4084
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4095
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4168
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid417
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid42
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4204
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4246
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4253
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4262
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4331
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4343
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4356
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4365
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid437
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4426
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4455
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4471
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid454
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4545
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4564
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4596
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4607
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid464
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4645
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4660
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4675
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4719
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid480
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4815
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4842
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid488
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4892
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid494
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid4991
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5003
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid501
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5019
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5024
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5038
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5045
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5087
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid509
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5103
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5110
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5124
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5155
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5169
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5193
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5225
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5233
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5241
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5249
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5260
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5275
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5317
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5327
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5337
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5342
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5351
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5362
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5372
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5398
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5407
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid541
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5417
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5432
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5441
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5452
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5471
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5513
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5523
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5537
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5544
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5575
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5587
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5592
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5627
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5635
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5651
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5659
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5692
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5696
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5700
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5702
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5705
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5709
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid571
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5713
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5717
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid5721
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid59
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid626
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid633
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid645
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid657
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid663
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid669
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid675
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid698
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid704
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid716
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid723
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid729
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid738
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid746
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid779
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid788
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid803
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid856
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid873
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid893
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid908
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid963
-_:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1006
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1019
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1033
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1049
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1067
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1074
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1080
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1092
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1102
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1110
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid112
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid115
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1157
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1163
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1182
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1201
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1211
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1221
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1228
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1241
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1264
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1271
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1279
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1296
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1306
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1327
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1343
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1351
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1361
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1438
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1487
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1494
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1501
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1507
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1526
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1533
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1552
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1565
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1585
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1592
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1598
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1639
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1654
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1666
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1675
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1686
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1714
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1721
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1728
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1734
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1740
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1747
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1755
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1762
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1769
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1775
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1781
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1787
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1794
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1801
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1808
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1851
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1857
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1866
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1872
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1878
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1884
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1890
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1897
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1905
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1911
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1916
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1924
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1937
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1944
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1951
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1958
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1966
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1975
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid1994
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2005
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2019
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2032
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2038
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2045
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2051
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2057
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2063
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2071
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2079
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2090
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2098
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2104
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2116
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2122
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2136
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2142
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2148
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2154
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2160
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2166
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2172
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2178
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2184
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2190
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2196
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2202
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2208
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2214
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2220
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2226
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2232
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2238
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2244
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2252
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2258
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2266
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2354
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2368
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2383
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2399
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2415
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2428
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2438
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2444
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2450
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2456
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2464
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2485
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2496
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2507
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2517
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2527
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2536
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2544
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2557
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2568
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2574
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2584
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2592
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2598
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2604
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2610
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2620
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2629
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2636
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2644
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2652
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2658
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2665
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2676
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2682
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2691
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2698
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2708
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2714
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2720
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2726
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2742
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2748
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2754
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2760
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2765
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2772
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2781
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2788
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2800
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2810
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2816
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2827
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2843
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2853
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2862
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2869
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2884
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2892
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2907
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2913
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2921
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2931
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2949
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2959
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2966
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2972
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2978
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2983
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2988
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid2994
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3000
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3026
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3036
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3043
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3049
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3056
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3064
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3070
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3076
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3082
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3089
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3098
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid31
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3104
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3110
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3116
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3122
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3128
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3134
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3146
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3153
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3160
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3168
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3179
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3185
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3191
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3197
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3203
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3209
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3216
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3222
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3228
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3238
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3246
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3252
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3263
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3269
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid327
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3275
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3281
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3292
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3301
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3307
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3314
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3320
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3326
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3332
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid334
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3340
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3350
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3357
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3362
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3374
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3381
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3398
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3411
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3419
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3426
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3432
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3444
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3451
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3457
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3469
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3484
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3490
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3496
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3503
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3513
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3519
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3529
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3535
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3545
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3551
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3558
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3564
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3569
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3576
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3590
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3598
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3604
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3610
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3616
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3627
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3633
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3642
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3709
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3752
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3758
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid385
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid39
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid3993
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4000
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4009
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4020
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4031
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid405
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4104
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4140
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4182
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4189
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4198
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid422
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4267
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4279
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4292
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4301
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid432
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4362
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4391
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4407
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid448
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4481
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4500
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4532
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4543
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid456
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4581
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4596
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4611
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid462
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4655
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid469
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4751
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid477
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4778
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4828
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4927
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4939
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4955
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4960
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4974
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid4981
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5023
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5039
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5046
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5060
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid509
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5091
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5105
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5129
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5161
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5169
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5177
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5185
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5196
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5211
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5253
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5263
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5273
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5278
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5287
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5298
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5308
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5334
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5343
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5353
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5368
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5377
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5388
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid539
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid54
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5407
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5449
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5459
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5473
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5480
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5511
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5523
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5528
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5563
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5571
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5587
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5595
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5628
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5630
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5633
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5637
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5641
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5645
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid5649
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid594
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid601
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid613
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid625
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid631
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid637
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid643
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid666
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid672
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid684
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid691
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid697
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid706
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid714
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid747
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid756
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid771
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid824
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid841
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid861
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid876
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid931
+_:Be90e3787X2D7eecX2D4c8bX2Dbef1X2D752ca68eb30bgenid962
"continuant"
"occurrent"
"independent continuant"
@@ -407,17 +397,6 @@ _:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
"specifically dependent continuant"
"material entity"
"immaterial entity"
- "anatomical entity"
- "connected anatomical structure"
- "material anatomical entity"
- "multicellular organism"
- "gross anatomical part"
- "organism"
- "multicellular anatomical structure"
- "cellular organism"
- "biological entity"
-
-
"cell"
"early embryonic cell (metazoa)"
"stem cell"
@@ -1036,7 +1015,6 @@ _:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
"qualitative"
"deviation (from_normal)"
"size"
- "mass"
"structure"
"maturity"
"branched"
@@ -1084,7 +1062,6 @@ _:Bfc6e1420X2D7c6dX2D43a2X2D806eX2Df76aacaa80e9genid994
"superelliptic"
"acidophilic"
"nucleated"
- "maximally connected"
"disconnected"
"polymeric"
"anatomical structure quality"
diff --git a/subsets/eye_upper_slim.json b/subsets/eye_upper_slim.json
index 7bc23a637..626805b20 100644
--- a/subsets/eye_upper_slim.json
+++ b/subsets/eye_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-09-21"
+ "val" : "2023-10-19"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-09-21/subsets/eye_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-10-19/subsets/eye_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -296,9 +296,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "occurs_in"
@@ -724,185 +721,6 @@
"val" : "in_dorsal_side_of"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "lbl" : "anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
- "xrefs" : [ "CAROC:Brownsville2014" ]
- },
- "comments" : [ "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "lbl" : "connected anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
- },
- "comments" : [ "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "lbl" : "material anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical entity that has mass."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "lbl" : "multicellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
- },
- "comments" : [ "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "lbl" : "gross anatomical part",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#plus" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "10.7.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "lbl" : "organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- },
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "organism or virus or viroid"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "Melissa Haendel"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "9/18/11"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "lbl" : "multicellular anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical structure that has more than one cell as a part."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "djs93"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "Sun Feb 27 10:53:00 GMT 2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "lbl" : "cellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An individual member of a clade of cellular organisms."
- },
- "comments" : [ "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. " ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "7.16.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "lbl" : "biological entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
- },
- "comments" : [ "Important for alignment with Darwin Core class \"Organism\"." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_33709",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A carboxylic acid containing one or more amino groups.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "Aminocarbonsaeure",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "Aminokarbonsaeure",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "Aminosaeure",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "amino acids",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_50860",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any molecular entity that contains carbon.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "organic compounds",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic entity",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic molecular entities",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000000",
"lbl" : "cell",
@@ -1040,7 +858,7 @@
"pred" : "hasExactSynonym",
"val" : "hemopoietic stem cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HSC"
}, {
@@ -1076,11 +894,11 @@
},
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BFU-E"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-E"
}, {
@@ -1141,17 +959,17 @@
"pred" : "hasExactSynonym",
"val" : "common myeloid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GEMM",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-S",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CMP",
"xrefs" : [ "ISBN:0878932437" ]
@@ -1336,7 +1154,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"
} ]
}
@@ -1529,7 +1347,7 @@
"xrefs" : [ "MESH:D009457" ]
},
"comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ],
- "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "neuroglial cell"
@@ -1545,6 +1363,10 @@
"val" : "FBbt:00005144"
}, {
"val" : "FMA:54536"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1655,15 +1477,15 @@
"val" : "marrow stromal cells",
"xrefs" : [ "PMID:11378515" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BMSC"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-F"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "MSC",
"xrefs" : [ "PMID:11378515" ]
@@ -1772,15 +1594,10 @@
"val" : "A cell that specializes in controlled release of one or more substances.",
"xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "BTO:0003659"
}, {
"val" : "FMA:86916"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1823,7 +1640,7 @@
"val" : "WBbt:0003675"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg"
} ]
}
@@ -1897,7 +1714,7 @@
"val" : "FMA:86740"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"
} ]
}
@@ -2302,7 +2119,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg"
} ]
}
@@ -2570,12 +2387,12 @@
"pred" : "hasExactSynonym",
"val" : "amacrine neuron"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "AC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "ACs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
@@ -2600,17 +2417,12 @@
"xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
},
"comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "angioblast"
}, {
"pred" : "hasExactSynonym",
"val" : "chondroplast"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -2822,12 +2634,12 @@
"pred" : "hasExactSynonym",
"val" : "ganglion cell of retina"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "RGC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "RGCs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
@@ -2858,12 +2670,12 @@
"pred" : "hasExactSynonym",
"val" : "horizontal cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "HCs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
@@ -2887,17 +2699,17 @@
},
"subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BC",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "BCs",
"xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003004",
"pred" : "hasRelatedSynonym",
"val" : "BPs",
"xrefs" : [ "GSE137537" ]
@@ -3323,7 +3135,6 @@
"val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.",
"xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "CALOHA:TS-2096"
}, {
@@ -3332,9 +3143,6 @@
"val" : "MESH:D003239"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- }, {
"pred" : "http://purl.org/dc/terms/contributor",
"val" : "https://orcid.org/0000-0003-1980-3228"
}, {
@@ -3584,12 +3392,7 @@
"definition" : {
"val" : "Any muscle cell in which the fibers are not organised into sarcomeres.",
"xrefs" : [ "GOC:DOS" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0008001",
@@ -3622,9 +3425,14 @@
"definition" : {
"val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
},
+ "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "mesenchyme cell"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -4078,20 +3886,6 @@
"val" : "cellular_component"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/GO_0001505",
- "lbl" : "regulation of neurotransmitter levels",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any process that modulates levels of neurotransmitter.",
- "xrefs" : [ "GOC:jl" ]
- },
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "biological_process"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/GO_0001508",
"lbl" : "action potential",
@@ -8039,7 +7833,7 @@
"pred" : "hasExactSynonym",
"val" : "non-membrane-enclosed organelle"
}, {
- "pred" : "hasNarrowSynonym",
+ "pred" : "hasRelatedSynonym",
"val" : "biological condensate"
} ],
"xrefs" : [ {
@@ -8530,6 +8324,9 @@
"val" : "Wikipedia:Organogenesis"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/25943"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -8971,13 +8768,16 @@
"val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.",
"xrefs" : [ "GOC:ai", "GOC:dos" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "establishment of localisation",
"xrefs" : [ "GOC:mah" ]
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -10214,8 +10014,11 @@
"val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
"xrefs" : [ "GOC:kmv" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
"val" : "kmv"
}, {
@@ -10594,7 +10397,7 @@
"val" : "http://purl.obolibrary.org/obo/IAO_0000122"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
- "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "PERSON:Daniel Schober"
@@ -11800,6 +11603,28 @@
"val" : "https://orcid.org/0000-0002-8688-6599"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/OMO_0003000",
+ "lbl" : "abbreviation",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A synonym type for describing abbreviations or initalisms"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/information-artifact-ontology/ontology-metadata/issues/122"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-4423-4370"
+ }, {
+ "pred" : "http://purl.org/dc/terms/created",
+ "val" : "2023-03-03"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/OMO_0003004",
"lbl" : "plural form",
@@ -11828,13 +11653,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.",
+ "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities",
"xrefs" : [ "PATOC:GVG" ]
},
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "trait"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
"val" : "PATO:0000072"
@@ -11922,22 +11743,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "lbl" : "mass",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.",
- "xrefs" : [ "PATOC:GVG" ]
- },
- "comments" : [ "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/pato#attribute_slim", "http://purl.obolibrary.org/obo/pato#relational_slim", "http://purl.obolibrary.org/obo/pato#scalar_slim" ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0000136",
"lbl" : "closure",
@@ -12247,9 +12052,6 @@
}, {
"pred" : "hasExactSynonym",
"val" : "multiply inhering quality of a physical entity"
- }, {
- "pred" : "hasExactSynonym",
- "val" : "multiply inhering quality of a physical entity "
}, {
"pred" : "hasExactSynonym",
"val" : "quality of a continuant"
@@ -12994,27 +12796,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "lbl" : "maximally connected",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.",
- "xrefs" : [ "GOC:dos" ]
- },
- "comments" : [ "What counts as maximally connected may be relative to some specification of granularity." ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-7073-9172"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
- "val" : "2014-12-12T08:41:11Z"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0010001",
"lbl" : "disconnected",
@@ -14643,7 +14424,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002000",
- "lbl" : "boundary_of",
+ "lbl" : "2D boundary of",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -14680,7 +14461,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002002",
- "lbl" : "has_boundary",
+ "lbl" : "has 2D boundary",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -15079,12 +14860,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a neuron and a material anatomical entity that its soma is part of."
},
- "xrefs" : [ {
- "val" : "RO:0002100"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15094,15 +14871,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some (\n and some ?Y)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15113,9 +14884,6 @@
"definition" : {
"val" : "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"
},
- "xrefs" : [ {
- "val" : "RO:0002101"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15134,9 +14902,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15173,8 +14938,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between an anatomical structure and a neuron that chemically synapses to it.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "
},
"xrefs" : [ {
"val" : "RO:0002103"
@@ -15191,18 +14955,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that has_part some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -15253,10 +15011,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "
},
- "comments" : [ "Relation between a neuron and the structure in which its dendrite receives synapses." ],
- "xrefs" : [ {
- "val" : "RO:0002110"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15269,9 +15023,6 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "synapsed in"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))"
@@ -15281,9 +15032,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15294,9 +15042,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."
},
- "xrefs" : [ {
- "val" : "RO:0002113"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15306,18 +15051,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15326,13 +15065,9 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that it chemically synapses to.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n "
},
"comments" : [ "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ],
- "xrefs" : [ {
- "val" : "RO:0002120"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15345,18 +15080,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15365,13 +15094,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
},
- "comments" : [ "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)" ],
- "xrefs" : [ {
- "val" : "RO:0002130"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15384,18 +15108,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15464,8 +15182,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."
},
"xrefs" : [ {
"val" : "RO:0002134"
@@ -15479,18 +15196,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that ( some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -16115,9 +15826,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "regulates"
@@ -16150,9 +15858,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "negatively_regulates"
@@ -16185,9 +15890,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "positively_regulates"
@@ -19853,6 +19555,47 @@
"val" : "https://orcid.org/0000-0003-4639-4431"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "lbl" : "has small molecule regulator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:27:26Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "lbl" : "has small molecule activator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
+ },
+ "xrefs" : [ {
+ "val" : "RO:0012001"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:28:37Z"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
+ "val" : "external"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
+ "val" : "has_small_molecule_activator"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012003",
"lbl" : "acts on population of",
@@ -19879,6 +19622,41 @@
"val" : "acts_on_population_of"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "lbl" : "is small molecule regulator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:17Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "lbl" : "is small molecule activator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:26Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_small_molecule_activator_of"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012008",
"lbl" : "results in fusion of",
@@ -39468,19 +39246,6 @@
"val" : "uberon"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/cl#abbreviation",
- "lbl" : "abbreviation",
- "type" : "PROPERTY",
- "meta" : {
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/elements/1.1/date",
- "val" : "2022-03-29T15:09:49Z"
- }, {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-1773-2692"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim",
"lbl" : "blood_and_immune_upper_slim",
@@ -40043,25 +39808,6 @@
"val" : "seeAlso"
} ]
}
- }, {
- "id" : "http://xmlns.com/foaf/0.1/depicted_by",
- "lbl" : "depicted by",
- "type" : "PROPERTY",
- "meta" : {
- "xrefs" : [ {
- "val" : "http://xmlns.com/foaf/0.1/depicted_by"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "uberon"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag",
- "val" : "true"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
- "val" : "depicted_by"
- } ]
- }
} ],
"edges" : [ {
"sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
@@ -40083,70 +39829,6 @@
"sub" : "http://purl.obolibrary.org/obo/BFO_0000141",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0030000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0010000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000125"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000012"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001008"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001993"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001010"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000000",
"pred" : "is_a",
@@ -42011,10 +41693,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0000792",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0000785"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0001505",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002160",
- "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0001508",
"pred" : "is_a",
@@ -42357,10 +42035,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0006865",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0006810"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0006865",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_33709"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0006915",
"pred" : "is_a",
@@ -42453,10 +42127,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0007268",
"pred" : "http://purl.obolibrary.org/obo/RO_0000057",
"obj" : "http://purl.obolibrary.org/obo/GO_0045202"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0007269",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/GO_0001505"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0007269",
"pred" : "is_a",
@@ -43405,10 +43075,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0048513",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0048856"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0048513",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002296",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0048598",
"pred" : "is_a",
@@ -43773,10 +43439,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0071704",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0008152"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0071704",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004007",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0071826",
"pred" : "is_a",
@@ -44033,10 +43695,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0099643",
"pred" : "http://purl.obolibrary.org/obo/RO_0002160",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0110165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0110165",
"pred" : "is_a",
@@ -44109,10 +43767,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_1901576",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0071704"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_1901576",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004008",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_1903047",
"pred" : "is_a",
@@ -44289,10 +43943,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0000117",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001018"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0000136",
"pred" : "is_a",
@@ -44517,10 +44167,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0002505",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0001404"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000141"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0010001",
"pred" : "is_a",
@@ -44827,10 +44473,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002497",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
"pred" : "is_a",
@@ -52534,10 +52176,30 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0011002",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012000"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012003",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002596"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002598"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012008",
"pred" : "subPropertyOf",
@@ -52842,36 +52504,20 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0003000",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012005"
}, {
"sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to"
} ],
"logicalDefinitionAxioms" : [ {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010000"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0000125"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001993"
- } ]
- }, {
"definedClassId" : "http://purl.obolibrary.org/obo/CL_0000005",
"genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ],
"restrictions" : [ {
@@ -53716,13 +53362,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0012003",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000763"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006865",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33709"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0006921",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ],
@@ -54087,13 +53726,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000000"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048513",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
- "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0048729",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ],
@@ -54227,13 +53859,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002588",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0043226"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071704",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0071826",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ],
@@ -54379,13 +54004,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901576",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_1903047",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009987" ],
@@ -55496,10 +55114,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0000278",
"pred" : "http://purl.obolibrary.org/obo/RO_0002162",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0001505",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002162",
- "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0005581",
"pred" : "http://purl.obolibrary.org/obo/RO_0002162",
@@ -55602,7 +55216,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002002",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040", "http://purl.obolibrary.org/obo/CARO_0000003" ],
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
diff --git a/subsets/eye_upper_slim.obo b/subsets/eye_upper_slim.obo
index ebd5d3647..22f785aa9 100644
--- a/subsets/eye_upper_slim.obo
+++ b/subsets/eye_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-09-21/subsets/eye_upper_slim.owl
+data-version: cl/releases/2023-10-19/subsets/eye_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,13 +82,12 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/eye_upper_slim
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -147,109 +138,6 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:33709
-namespace: chebi_ontology
-def: "A carboxylic acid containing one or more amino groups." [ANON:ANON]
-synonym: "amino acids" RELATED [ChEBI:]
-synonym: "Aminocarbonsaeure" RELATED [ChEBI:]
-synonym: "Aminokarbonsaeure" RELATED [ChEBI:]
-synonym: "Aminosaeure" RELATED [ChEBI:]
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -346,7 +234,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -392,10 +280,10 @@ id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
-synonym: "BFU-E" RELATED abbreviation []
+synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
-synonym: "CFU-E" RELATED abbreviation []
+synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
@@ -424,9 +312,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -522,7 +410,7 @@ xref: WBbt:0003672
is_a: CL:0000000 ! cell
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000071
@@ -654,6 +542,7 @@ name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: general_cell_types_upper_slim
+subset: human_reference_atlas
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
@@ -661,6 +550,7 @@ xref: CALOHA:TS-0415
xref: FBbt:00005144
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000126
@@ -713,9 +603,9 @@ id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -723,7 +613,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -771,14 +661,12 @@ is_a: CL:0000147 ! pigment cell
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000183
@@ -801,7 +689,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000192
@@ -845,7 +733,7 @@ is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -1124,7 +1012,7 @@ is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000541
@@ -1359,8 +1247,8 @@ name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "AC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "ACs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "AC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "ACs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FMA:67766
@@ -1376,7 +1264,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -1387,7 +1274,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -1517,8 +1403,8 @@ subset: eye_upper_slim
subset: human_reference_atlas
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
-synonym: "RGC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "RGCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
@@ -1532,8 +1418,8 @@ name: retina horizontal cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "HC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "HCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "HC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "HCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
is_a: CL:0000099 ! interneuron
@@ -1546,9 +1432,9 @@ name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
subset: eye_upper_slim
subset: human_reference_atlas
-synonym: "BC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "BCs" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
-synonym: "BPs" RELATED abbreviation [GSE137537]
+synonym: "BC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
+synonym: "BCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
+synonym: "BPs" RELATED OMO:0003004 [GSE137537]
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
@@ -1850,7 +1736,6 @@ creation_date: 2010-09-15T01:34:57Z
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -1859,7 +1744,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -2011,9 +1895,7 @@ creation_date: 2012-06-27T08:27:35Z
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
-subset: human_reference_atlas
is_a: CL:0000187 ! muscle cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0008001
@@ -2035,10 +1917,12 @@ relationship: part_of UBERON:8600004 ! visceral muscle tissue
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0008028
@@ -2284,14 +2168,6 @@ xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin
property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI
-[Term]
-id: GO:0001505
-name: regulation of neurotransmitter levels
-namespace: biological_process
-def: "Any process that modulates levels of neurotransmitter." [GOC:jl]
-relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
-relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-
[Term]
id: GO:0001508
name: action potential
@@ -2892,9 +2768,6 @@ def: "The directed movement of amino acids, organic acids containing one or more
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006810 ! transport
-intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:33709
-relationship: has_primary_input CHEBI:33709
[Term]
id: GO:0006915
@@ -3081,7 +2954,6 @@ comment: A neurotransmitter is any of a group of substances that are released on
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
@@ -4453,7 +4325,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -4729,9 +4601,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048598
@@ -4979,12 +4849,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051239
@@ -5325,9 +5197,6 @@ synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:50860
-relationship: has_primary_input_or_output CHEBI:50860
created_by: mah
creation_date: 2010-03-08T03:32:18Z
@@ -5663,10 +5532,11 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -5770,9 +5640,6 @@ synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:50860
-relationship: has_primary_output CHEBI:50860
created_by: pr
creation_date: 2012-11-05T11:04:40Z
@@ -6158,8 +6025,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -6205,17 +6070,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000136
name: closure
@@ -6371,7 +6225,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -6753,16 +6606,6 @@ is_a: PATO:0001404 ! nucleate quality
relationship: dc-contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -7351,7 +7194,7 @@ intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
[Term]
id: UBERON:0000025
@@ -7443,8 +7286,8 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: has_part UBERON:0001136 ! mesothelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0000060 ! anatomical wall
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: UBPROP:0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005425", ontology="TAO", source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000001 "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" xsd:string {source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." xsd:string {external_ontology="FMA"}
@@ -7547,7 +7390,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological_process
@@ -7726,7 +7568,7 @@ xref: Wikipedia:External_ectoderm
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0000924 {source="EHDAA2"} ! ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
property_value: editor_note "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" xsd:string
property_value: RO:0002171 UBERON:0002346
property_value: UBPROP:0000011 "(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis" xsd:string
@@ -7890,7 +7732,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -8058,7 +7900,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -8151,7 +7993,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -8611,7 +8453,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -8642,7 +8484,7 @@ is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: has_part CL:0000076 ! squamous epithelial cell
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"}
[Term]
@@ -8787,7 +8629,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -8862,7 +8704,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -8902,8 +8744,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -8949,7 +8791,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -8988,7 +8830,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -9209,7 +9051,7 @@ is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: has_quality PATO:0002124 ! laminar
relationship: has_quality PATO:0002124 ! laminar
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
property_value: editor_note "TODO - merge with cell layer?" xsd:string
property_value: UBPROP:0000007 "laminar" xsd:string
@@ -9261,7 +9103,7 @@ intersection_of: extends_fibers_into UBERON:0001908 ! optic tract
intersection_of: part_of UBERON:0001894 ! diencephalon
relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II
relationship: extends_fibers_into UBERON:0001908 ! optic tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b3/1543%2CVisalius%27OpticChiasma.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The point at which fibers of the optic nerves cross.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010622", ontology="AAO", source="AAO:DSM"}
property_value: UBPROP:0000003 "The chiasm has been studied in great detail in some animals, while in others relatively little or nothing is known. Although there are some gross architectural features that are conserved within some animals, such as birds and fish, the general picture is one of diversity. This review will attempt to consider the key features of such diversity of chiasmatic organisation in vertebrates and the mechanisms that sculpt them from the limited literature that is available. However, as so much research has been undertaken on the structure and development of the chiasm in laboratory animals, any review must consider the information that has been gleaned from them and hope that future studies will determine whether the features revealed in these animals, and the underlying mechanisms that generate them, have a common vertebrate plan.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000190", ontology="VHOG", source="DOI:10.1016/j.preteyeres.2005.04.005 Jeffery G, Erskine L, Variations in the architecture and development of the vertebrate optic chiasm. Progress in retinal and eye research (2005)", source="http://bgee.unil.ch/"}
@@ -9313,7 +9155,7 @@ relationship: part_of UBERON:0001801 {source="MA"} ! anterior segment of eyeball
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: part_of UBERON:0012430 {source="FMA-isa"} ! tunica fibrosa of eyeball
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000007 "corneal" xsd:string
property_value: UBPROP:0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" xsd:string
@@ -9418,7 +9260,7 @@ relationship: never_in_taxon NCBITaxon:6656
relationship: part_of UBERON:0001802 ! posterior segment of eyeball
relationship: part_of UBERON:0019207 ! chorioretinal region
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000152", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "retinal" xsd:string
@@ -9554,7 +9396,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -9636,7 +9478,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073
relationship: never_in_taxon NCBITaxon:6157
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -9677,7 +9519,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -9733,8 +9575,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -9877,7 +9719,7 @@ is_a: UBERON:0015203 ! non-connected functional system
relationship: capable_of_part_of GO:0007600 ! sensory perception
relationship: overlaps UBERON:0001016 ! nervous system
relationship: part_of UBERON:0004456 ! entire sense organ system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string
@@ -9946,7 +9788,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -10026,7 +9868,7 @@ intersection_of: has_part CL:0000192 ! smooth muscle cell
relationship: composed_primarily_of CL:0000192 ! smooth muscle cell
relationship: has_part CL:0000192 ! smooth muscle cell
relationship: has_part GO:0071953 ! elastic fiber
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/3/3b/Glatte_Muskelzellen.jpg" xsd:anyURI
property_value: UBPROP:0000001 "A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005274", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010244", ontology="AAO", source="AAO:CAM"}
property_value: UBPROP:0000003 "(...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001246", ontology="VHOG", source="DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011)", source="http://bgee.unil.ch/"}
@@ -10062,7 +9904,7 @@ intersection_of: develops_from UBERON:0000926 ! mesoderm
intersection_of: part_of UBERON:0000042 ! serous membrane
relationship: composed_primarily_of CL:0000077 {source="FMA"} ! mesothelial cell
relationship: part_of UBERON:0000042 ! serous membrane
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg" xsd:anyURI
[Term]
id: UBERON:0001137
@@ -10087,7 +9929,7 @@ xref: UMLS:C0004600 {source="ncithesaurus:Back"}
xref: Wikipedia:Dorsum_(anatomy)
is_a: UBERON:0000475 ! organism subdivision
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG" xsd:anyURI
property_value: UBPROP:0000007 "dorsal" xsd:string
property_value: UBPROP:0000008 "In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body" xsd:string
@@ -10177,7 +10019,7 @@ xref: Wikipedia:Face
is_a: UBERON:0001444 ! subdivision of head
relationship: contributes_to_morphology_of UBERON:0000033 ! head
relationship: has_part UBERON:0000165 ! mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face." xsd:string {source="FMA:24728"}
property_value: UBPROP:0000001 "The area that extends from the median ocellus to the oral foramen[HAO]." xsd:string {source="HAO:0000316", source="http://api.hymao.org/api/ref/67791", taxon="NCBITaxon:7399"}
property_value: UBPROP:0000007 "facial" xsd:string
@@ -10253,7 +10095,7 @@ is_a: UBERON:0010314 ! structure with developmental contribution from neural cre
is_a: UBERON:0011222 {source="FMA"} ! intra-ocular muscle
relationship: part_of UBERON:0001775 {source="FMA"} ! ciliary body
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png" xsd:anyURI
[Term]
id: UBERON:0001630
@@ -10319,7 +10161,7 @@ relationship: capable_of GO:0060082 ! eye blink reflex
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: part_of UBERON:0000019 {source="multiple"} ! camera-type eye
relationship: protects UBERON:0010409 ! ocular surface region
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg" xsd:anyURI
property_value: UBPROP:0000007 "blepharic" xsd:string
property_value: UBPROP:0000007 "palpebral" xsd:string
property_value: UBPROP:0000008 "In humans the upper and lower eyelid consists of the following layers, starting anteriorly: (1) skin, (2) a layer of subcutaneous connective tissue, (3) a layer of striated muscle fibres of the orbicularis muscle, (4) a layer of submuscular connective tissue, (5) a fibrous layer, including the tarsal plates, (6) a layer of smooth muscle, (7) the palpebral conjunctiva." xsd:string
@@ -10356,7 +10198,7 @@ xref: Wikipedia:Anterior_chamber_of_eyeball
is_a: UBERON:0006311 {source="FMA"} ! chamber of eyeball
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001431", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/anterior+chamber"}
property_value: UBPROP:0000012 "space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball" xsd:string {external_ontology="EHDAA2"}
@@ -10391,7 +10233,7 @@ relationship: has_part UBERON:0001775 ! ciliary body
relationship: has_part UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
relationship: present_in_taxon NCBITaxon:7955 {source="DOI:10.1177/0192623311409597"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png" xsd:anyURI
property_value: editor_note "TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus" xsd:string
property_value: UBPROP:0000007 "uveal" xsd:string
@@ -10484,7 +10326,7 @@ relationship: bounding_layer_of UBERON:0000964 ! cornea
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002187", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"}
property_value: UBPROP:0000008 "In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei" xsd:string
property_value: UBPROP:0000008 "In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals" xsd:string
@@ -10523,7 +10365,7 @@ relationship: has_part CL:0000347 {source="ZFA"} ! scleral cell
relationship: has_quality PATO:0000963 ! opaque
relationship: part_of UBERON:0012430 {source="FMA"} ! tunica fibrosa of eyeball
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]." xsd:string {source="Wikipedia:Sclera"}
property_value: UBPROP:0000001 "The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001274", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/sclera"}
property_value: UBPROP:0000007 "scleral" xsd:string
@@ -10569,7 +10411,7 @@ relationship: has_part UBERON:0001605 ! ciliary muscle
relationship: has_part UBERON:0010427 ! ciliary processes
relationship: part_of UBERON:0011892 ! anterior uvea
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000102", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
[Term]
@@ -10614,7 +10456,7 @@ relationship: overlaps UBERON:0001802 {source="Wikipedia"} ! posterior segment o
relationship: part_of UBERON:0001768 {source="MA"} ! uvea
relationship: part_of UBERON:0019207 ! chorioretinal region
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: editor_note "check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA" xsd:string
property_value: UBPROP:0000007 "choroidal" xsd:string
property_value: UBPROP:0000012 "MP treats posterior uvea and optic choroid as distinct" xsd:string {external_ontology="MP"}
@@ -10653,7 +10495,7 @@ relationship: adjacent_to UBERON:0004370 ! anterior limiting lamina of cornea
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: develops_from UBERON:0007213 {inferred_by="cjm", source="ISBN:0781772214", source="Wikipedia"} ! mesenchyme derived from head neural crest
relationship: part_of UBERON:0000964 ! cornea
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of tissue that is located basal to Bowman's layer and distal to Descemet's membrane and is comprised largely of connective tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO", source="ZFIN:ZDB-PUB-061010-3"}
property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: develops_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"}
property_value: UBPROP:0000002 "relationship type change: subclass tissue (CARO:0000043) CHANGED TO: has_developmental_contribution_from tissue (UBERON:0000479)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002189", ontology="TAO"}
@@ -10763,7 +10605,7 @@ relationship: adjacent_to UBERON:0003902 ! retinal neural layer
relationship: has_part GO:0048770 ! pigment granule
relationship: immediate_transformation_of UBERON:0005424 ! presumptive retinal pigmented epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000144", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The monolayer of pigmented epithelium covering the neural retina.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011096", ontology="AAO", source="ZFA:0000144"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000536", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -10796,7 +10638,7 @@ is_a: UBERON:0001781 ! layer of retina
relationship: adjacent_to UBERON:0001788 ! outer limiting layer of retina
relationship: has_part CL:0000287 {source="ZFA"} ! eye photoreceptor cell
relationship: part_of UBERON:0003902 ! retinal neural layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "we follow MA and ZFA in subdividing this into inner and outer segments" xsd:string {external_ontology="MA"}
@@ -10994,7 +10836,7 @@ relationship: composed_primarily_of CL:0000740 ! retinal ganglion cell
relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer
relationship: part_of UBERON:0003902 {source="FMA"} ! retinal neural layer
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "a layer of the retina that consists of retinal ganglion cells[WP]. innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain[Wikipedia:Ganglion_cell_layer]." xsd:string {source="Wikipedia:Ganglion_cell_layer"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030]" xsd:string {external_ontology="NIF"}
@@ -11114,7 +10956,7 @@ relationship: has_part GO:0030425 ! dendrite
relationship: overlaps CL:0000740 ! retinal ganglion cell
relationship: overlaps CL:0000748 ! retinal bipolar neuron
relationship: part_of UBERON:0003902 ! retinal neural layer
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png" xsd:anyURI
property_value: UBPROP:0000001 "The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells[GO][GO:0010842]." xsd:string {source="GO:0010842"}
property_value: UBPROP:0000001 "The layer within the retina where the bipolar cells synapse with the dendrites of the ganglion cells.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001329", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001168", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -11149,7 +10991,7 @@ is_a: UBERON:0006312 ! ocular refractive media
is_a: UBERON:0006314 ! bodily fluid
relationship: contributes_to_morphology_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 {notes="FMA def states A and P", notes="located_in in EHDAA2", source="VHOG"} ! anterior chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: UBPROP:0000001 "The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/aqueous+humour"}
property_value: UBPROP:0000003 "(...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000548", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa." xsd:string {external_ontology="FMA"}
@@ -11187,7 +11029,7 @@ is_a: UBERON:0006312 ! ocular refractive media
relationship: has_quality PATO:0000964 ! transparent
relationship: located_in UBERON:0005606 ! hyaloid cavity
relationship: part_of UBERON:0001798 ! vitreous body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
[Term]
id: UBERON:0001798
@@ -11209,7 +11051,7 @@ is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue
relationship: composed_primarily_of UBERON:0001797 ! vitreous humor
relationship: has_developmental_contribution_from UBERON:0002346 {notes="neural ectoderm of optic cup", source="ISBN:0781772214"} ! neurectoderm
relationship: part_of UBERON:0001799 ! vitreous chamber of eyeball
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: editor_note "distinciton between body and humor requires more work. These may be merged in future. Note that FMA includes the hyaloid canal as part of the vitreous body" xsd:string
[Term]
@@ -11266,7 +11108,7 @@ disjoint_from: UBERON:0001802 {source="lexical"} ! posterior segment of eyeball
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: in_anterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye
relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001802 {exceptions="ZFA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
[Term]
@@ -11295,7 +11137,7 @@ is_a: UBERON:0000063 ! organ subunit
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: in_posterior_side_of UBERON:0010230 {source="cjm"} ! eyeball of camera-type eye
relationship: part_of UBERON:0010230 {source="FMA"} ! eyeball of camera-type eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
[Term]
id: UBERON:0001811
@@ -11333,7 +11175,7 @@ relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external
relationship: part_of UBERON:0005908 {source="cjm"} ! conjunctival sac
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png" xsd:anyURI
property_value: UBPROP:0000007 "conjunctival" xsd:string
[Term]
@@ -11381,7 +11223,7 @@ relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: develops_from UBERON:0003080 ! anterior neural tube
relationship: immediate_transformation_of UBERON:0006240 {evidence="definitional"} ! future forebrain
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: UBPROP:0000001 "Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010147", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000002 "relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000109", ontology="TAO"}
@@ -11437,7 +11279,7 @@ relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: has_developmental_contribution_from UBERON:0003849 {evidence="definitional"} ! mesencephalic neural crest
relationship: immediate_transformation_of UBERON:0009616 {source="Bgee:AN"} ! presumptive midbrain
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG" xsd:anyURI
property_value: editor_note "developmental relationships need revised" xsd:string
property_value: RO:0002171 UBERON:0001894 {exceptions="ZFA", exceptions_url="https://github.com/obophenotype/uberon/issues/378", source="ABA", status="pending"}
property_value: RO:0002171 UBERON:0002028 {exceptions="ZFA", source="ABA", status="pending"}
@@ -11508,7 +11350,7 @@ relationship: has_developmental_contribution_from UBERON:0003851 {evidence="defi
relationship: immediate_transformation_of UBERON:0006222 {evidence="definitional"} ! future diencephalon
relationship: part_of UBERON:0001890 ! forebrain
relationship: present_in_taxon NCBITaxon:7762 {notes="not well differentiated from the cerebrum. (Ariens, p. 868)", source="PMID:8932866"}
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0002028 {source="ABA"}
property_value: UBPROP:0000001 "The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000101", ontology="TAO", source="ZFIN:curator"}
@@ -11570,7 +11412,7 @@ relationship: capable_of GO:0044058 ! regulation of digestive system process
relationship: part_of UBERON:0002298 ! brainstem
relationship: part_of UBERON:0005290 ! myelencephalon
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010486", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000181", ontology="VHOG", source="DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008)", source="http://bgee.unil.ch/"}
@@ -11619,7 +11461,7 @@ relationship: innervates UBERON:0000966 ! retina
relationship: part_of UBERON:0002104 ! visual system
relationship: part_of UBERON:0003931 ! diencephalic white matter
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f6/Gray773.png" xsd:anyURI
property_value: editor_note "relationships need checking by expert. NIF and ZFA both state part of diencepahalon; MA says part of optic nerve II. in uberon, CNS and PNS are spatially disjoint, and axon tracts are part of the CNS so we make the relationship to CNII 'continuous_with'" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:string
@@ -11665,7 +11507,7 @@ relationship: develops_from UBERON:0010285 {source="ZFA"} ! midbrain basal plate
relationship: part_of UBERON:0001891 ! midbrain
relationship: part_of UBERON:0002298 ! brainstem
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png" xsd:anyURI
property_value: UBPROP:0000003 "Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001367", ontology="VHOG", source="DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005)", source="http://bgee.unil.ch/"}
[Term]
@@ -11751,7 +11593,7 @@ relationship: has_part CL:0000071 {source="AEO"} ! blood vessel endothelial cell
relationship: has_part UBERON:0007500 {source="EHDAA2"} ! epithelial tube open at both ends
relationship: has_quality PATO:0002045 ! dendritic
relationship: part_of UBERON:0004537 ! blood vasculature
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus" xsd:string
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001250", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Any of the vessels through which blood circulates in the body.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011004", ontology="AAO", source="AAO:EJS"}
@@ -11793,7 +11635,7 @@ relationship: adjacent_to UBERON:0001766 ! anterior chamber of eyeball
relationship: contributes_to_morphology_of UBERON:0000964 ! cornea
relationship: part_of UBERON:0000964 ! cornea
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png" xsd:anyURI
[Term]
id: UBERON:0001986
@@ -11857,7 +11699,7 @@ xref: Wikipedia:Gray_matter
xref: ZFA:0001681
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: composed_primarily_of GO:0043025 ! neuronal cell body
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002197", ontology="TAO", source="ZFIN:curator"}
[Term]
@@ -11907,7 +11749,7 @@ relationship: only_in_taxon NCBITaxon:89593 ! Craniata
relationship: overlaps UBERON:0002298 {notes="modified-source-relation", source="ABA"} ! brainstem
relationship: present_in_taxon NCBITaxon:7762 {source="PMID:8932866"}
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002171 UBERON:0001891 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0001894 {source="ABA"}
property_value: UBPROP:0000001 "Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010150", ontology="AAO", source="AAO:BJB"}
@@ -11936,7 +11778,7 @@ relationship: composed_primarily_of UBERON:0000055 ! vessel
relationship: has_part UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0007798 ! vascular system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: editor_note "see also: vascular system. Consider merging?" xsd:string
property_value: UBPROP:0000007 "vascular" xsd:string
@@ -12250,8 +12092,8 @@ intersection_of: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
intersection_of: part_of UBERON:0002323 ! coelemic cavity lumen
relationship: luminal_space_of UBERON:0000915 ! thoracic segment of trunk
relationship: part_of UBERON:0002323 ! coelemic cavity lumen
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg" xsd:anyURI
property_value: UBPROP:0000008 "In many species, the diaphragm separates thoracic and abdominal cavities" xsd:string
[Term]
@@ -12314,7 +12156,7 @@ relationship: has_part CL:0005000 {source="ZFA"} ! spinal cord interneuron
relationship: immediate_transformation_of UBERON:0006241 {evidence="definitional"} ! future spinal cord
relationship: part_of UBERON:0001017 ! central nervous system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg" xsd:anyURI
property_value: editor_note "TODO - add superclass to unify with VNC?" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb" xsd:string
@@ -12364,7 +12206,7 @@ relationship: continuous_with UBERON:0002240 ! spinal cord
relationship: contributes_to_morphology_of UBERON:0000955 ! brain
relationship: has_part UBERON:0001896 ! medulla oblongata
relationship: has_part UBERON:0001943 ! midbrain tegmentum
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001890 {notes="we apply a strict definition"}
property_value: RO:0002171 UBERON:0002037 {exceptions="ZFA", source="ABA", source="https://github.com/obophenotype/uberon/issues/378", status="pending"}
property_value: RO:0002171 UBERON:0002314 {notes="we apply a strict definition"}
@@ -12408,8 +12250,8 @@ xref: Wikipedia:White_matter
xref: ZFA:0001682
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: composed_primarily_of UBERON:0006135 ! myelinated nerve fiber
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/d7/Grey_matter_and_white_matter_-_very_high_mag.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/d/d2/Spinal_nerve.svg" xsd:anyURI
property_value: UBPROP:0000001 "Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929]." xsd:string {source="FMA:83929"}
property_value: UBPROP:0000001 "Multi-tissue structure comprised largely of myelinated axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002142", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001764", ontology="VHOG", source="DOI:10.1038/nature09614 Nave KA, Myelination and support of axonal integrity by glia. Nature (2010)", source="http://bgee.unil.ch/"}
@@ -12498,7 +12340,7 @@ relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -12547,7 +12389,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -12596,8 +12438,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -12815,7 +12657,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -13040,7 +12882,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -13138,7 +12980,7 @@ intersection_of: has_potential_to_develop_into UBERON:0000965 ! lens of camera-t
relationship: developmentally_induced_by UBERON:0004128 ! optic vesicle
relationship: has_potential_to_develop_into UBERON:0000965 ! lens of camera-type eye
relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
property_value: UBPROP:0000001 "Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000122", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000166", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006)" xsd:string {source="NCBIBook:NBK53175"}
@@ -13177,7 +13019,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -13226,7 +13068,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -13279,7 +13121,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -13336,7 +13178,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -13367,7 +13209,7 @@ is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0034705 {source="EHDAA2"} ! developing neuroepithelium
relationship: develops_from UBERON:0003072 ! optic cup
relationship: part_of UBERON:0001894 ! diencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png" xsd:anyURI
property_value: UBPROP:0000001 "The evagination from the neural tube of the developing embryo which develops the optic cup at its extremity; the stalk persists as the optic nerve. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000223", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/optic+stalk"}
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000223", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
@@ -13457,7 +13299,7 @@ intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -13981,7 +13823,7 @@ relationship: developmentally_induced_by UBERON:0004880 ! chordamesoderm
relationship: develops_from UBERON:0002346 {source="GO-def"} ! neurectoderm
relationship: develops_from UBERON:0003071 {source="ZFA"} ! eye primordium
relationship: part_of UBERON:0010312 {source="ZFA"} ! immature eye
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png" xsd:anyURI
property_value: UBPROP:0000003 "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
[Term]
@@ -14785,7 +14627,7 @@ xref: Wikipedia:Myelencephalon
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004733 ! segmental subdivision of hindbrain
relationship: immediate_transformation_of UBERON:0010096 {evidence="definitional"} ! future myelencephalon
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:7955
property_value: UBPROP:0000001 "The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000456", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/myelencephalon"}
property_value: UBPROP:0000003 "The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000456", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500", source="http://bgee.unil.ch/"}
@@ -15088,7 +14930,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -16226,7 +16068,7 @@ xref: SCTID:280860001
xref: Wikipedia:Ciliary_processes
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0001775 ! ciliary body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_L.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Eye_R.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Eye_L.glb" xsd:string
@@ -17032,7 +16874,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -17044,7 +16885,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -17148,10 +16989,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -17160,15 +16998,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -17213,10 +17047,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -17227,15 +17058,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -17243,34 +17071,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -17279,7 +17098,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -17449,7 +17267,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -17500,7 +17318,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -17708,7 +17526,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -17798,7 +17616,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -18055,6 +17873,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -18187,7 +18032,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -18235,7 +18080,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -18313,7 +18158,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -18556,13 +18401,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -18897,7 +18735,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -18909,7 +18746,6 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
is_a: RO:0002323 ! mereotopologically related to
@@ -19035,7 +18871,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -19225,12 +19061,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -19475,10 +19322,8 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -19486,7 +19331,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
domain: UBERON:0000122 ! neuron projection bundle
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -19529,8 +19373,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -19586,7 +19430,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19635,7 +19478,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -19695,7 +19537,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -19769,7 +19611,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -19955,7 +19796,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -20345,10 +20185,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -20357,7 +20195,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/subsets/eye_upper_slim.owl b/subsets/eye_upper_slim.owl
index b40240ccd..5834aa177 100644
--- a/subsets/eye_upper_slim.owl
+++ b/subsets/eye_upper_slim.owl
@@ -10,10 +10,8 @@
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
- xmlns:caro="http://purl.obolibrary.org/obo/caro#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
- xmlns:fbbt="http://purl.obolibrary.org/obo/fbbt#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo2="http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/"
xmlns:pato="http://purl.obolibrary.org/obo/pato#"
@@ -31,8 +29,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-09-21
+
+ 2023-10-19
@@ -99,7 +97,7 @@ We don't have definitions of 'meaning' or 'expression'
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
@@ -273,18 +271,6 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
-
-
-
-
-
-
-
-
-
-
-
-
@@ -315,6 +301,19 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
+
+
+
+ CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
+ A synonym type for describing abbreviations or initalisms
+
+
+ 2023-03-03
+ abbreviation
+
+
+
+
@@ -675,22 +674,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -699,17 +682,6 @@ WHERE {
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -749,46 +721,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1043,14 +975,6 @@ WHERE {
-
-
-
-
-
-
-
-
@@ -1547,12 +1471,6 @@ WHERE {
-
-
-
-
-
-
@@ -2016,14 +1934,7 @@ WHERE {
-
- http://xmlns.com/foaf/0.1/depicted_by
- uberon
- depicted_by
- true
- depicted_by
- depicted by
-
+
@@ -2222,7 +2133,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
unfolds_in
BFO:0000066
external
- gene_ontology
occurs_in
@@ -2917,7 +2827,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
surface of
2D boundary of
- boundary_of
@@ -2927,7 +2836,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
-
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
@@ -2943,7 +2851,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
has_boundary
has 2D boundary
has 2D boundary
- has_boundary
@@ -3292,23 +3199,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and a material anatomical entity that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
- BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)
- RO:0002100
- fly_anatomy.ontology
- has_soma_location
has soma location
-
-
-
- Relation between a neuron and an anatomical structure that its soma is part of.
-
-
@@ -3320,7 +3216,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3347,17 +3242,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
))))))
- RO:0002101
- fly_anatomy.ontology
- fasciculates_with
fasciculates with
-
-
-
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
-
-
@@ -3403,27 +3289,18 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
- Relation between an anatomical structure and a neuron that chemically synapses to it.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))
RO:0002103
- fly_anatomy.ontology
uberon
synapsed_by
synapsed_by
synapsed by
synapsed by
-
-
-
- Relation between an anatomical structure and a neuron that chemically synapses to it.
-
-
@@ -3462,16 +3339,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
synapsed in
- BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))
http://purl.obolibrary.org/obo/BFO_0000051 some (
http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (
http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))
- RO:0002110
- fly_anatomy.ontology
- has_postsynaptic_terminals_in
- Relation between a neuron and the structure in which its dendrite receives synapses.
has postsynaptic terminal in
@@ -3490,12 +3362,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
synapses in
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))
- RO:0002113
- fly_anatomy.ontology
- has_presynaptic_terminals_in
has presynaptic terminal in
@@ -3519,16 +3387,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
- Relation between a neuron and an anatomical structure that it chemically synapses to.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))
- RO:0002120
- fly_anatomy.ontology
- synapsed_to
N1 synapsed_to some N2
Expands to:
N1 SubclassOf (
@@ -3538,12 +3401,6 @@ N1 SubclassOf (
‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
-
-
-
- Relation between a neuron and an anatomical structure that it chemically synapses to.
-
-
@@ -3558,25 +3415,13 @@ N1 SubclassOf (
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synapse in
<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)
- RO:0002130
- fly_anatomy.ontology
- has_synaptic_terminals_in
- expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
has synaptic terminal in
-
-
-
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
-
-
@@ -3690,26 +3535,17 @@ N1 SubclassOf (
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))
RO:0002134
- fly_anatomy.ontology
uberon
innervates
innervates
innervates
innervates
-
-
-
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
@@ -4189,7 +4025,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.false
RO:0002211
external
- gene_ontology
regulates
@@ -4218,7 +4053,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002212
external
- gene_ontology
negatively_regulates
@@ -4252,7 +4086,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002213
external
- gene_ontology
positively_regulates
@@ -7269,6 +7102,37 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is regulated by the small molecule continuant
+
+ 2020-04-22T20:27:26Z
+ has small molecule regulator
+
+
+
+
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is activated by the small molecule continuant
+
+ 2020-04-22T20:28:37Z
+ RO:0012001
+ external
+ has_small_molecule_activator
+ has_small_molecule_activator
+ has small molecule activator
+ has small molecule activator
+
+
+
+
@@ -7289,6 +7153,32 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process
+
+ 2020-06-24T13:15:17Z
+ is small molecule regulator of
+
+
+
+
+
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that activates the process
+
+ 2020-06-24T13:15:26Z
+ is small molecule activator of
+ https://wiki.geneontology.org/Is_small_molecule_activator_of
+
+
+
+
@@ -8047,283 +7937,6 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CARO:0000000
- Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
- anatomical entity
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CAROC:Brownsville2014
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
- CARO:0000003
-
- Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
- connected anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical entity that has mass.
- CARO:0000006
-
- material anatomical entity
-
-
-
-
-
-
-
-
- Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell.
- CARO:0000012
- MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-
-MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
- multicellular organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
-
- 10.7.2011
-
- gross anatomical part
-
-
-
-
-
-
-
-
- Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
- Melissa Haendel
- 9/18/11
- organism or virus or viroid
- organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical structure that has more than one cell as a part.
- djs93
- Sun Feb 27 10:53:00 GMT 2011
- CARO:0010000
-
- multicellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
-
-
-
-
-
-
-
-
-
- An individual member of a clade of cellular organisms.
-
- 7.16.2011
- CARO:0010004
- A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
- cellular organism
-
-
-
-
-
-
-
-
- Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them.
- Important for alignment with Darwin Core class "Organism".
- biological entity
-
-
-
-
-
-
-
- A carboxylic acid containing one or more amino groups.
- chebi_ontology
- Aminocarbonsaeure
- Aminokarbonsaeure
- Aminosaeure
- amino acids
- CHEBI:33709
-
-
-
-
- A carboxylic acid containing one or more amino groups.
- ANON:ANON
-
-
-
-
- Aminocarbonsaeure
- ChEBI:
-
-
-
-
- Aminokarbonsaeure
- ChEBI:
-
-
-
-
- Aminosaeure
- ChEBI:
-
-
-
-
- amino acids
- ChEBI:
-
-
-
-
-
-
-
- Any molecular entity that contains carbon.
- chebi_ontology
- organic compounds
- organic entity
- organic molecular entities
- CHEBI:50860
-
-
-
-
- Any molecular entity that contains carbon.
- ANON:ANON
-
-
-
-
- organic compounds
- ChEBI:
-
-
-
-
- organic entity
- ChEBI:
-
-
-
-
- organic molecular entities
- ChEBI:
-
-
-
-
@@ -8722,7 +8335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
HSC
-
+
@@ -8766,13 +8379,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BFU-E
-
+
CFU-E
-
+
@@ -8858,21 +8471,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -9085,7 +8698,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -9430,6 +9043,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
+
BTO:0002606
CALOHA:TS-0415
FBbt:00005144
@@ -9437,6 +9051,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neuroglial cell
neuroglia
+
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
glial cell
@@ -9625,20 +9240,20 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -9766,10 +9381,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -9819,7 +9432,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -9942,7 +9555,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CALOHA:TS-0868
FMA:86740
photoreceptor cell
- https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
+ https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
@@ -10708,7 +10321,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -11721,15 +11334,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
AC
doi:10.1038/s41598-020-66092-9
-
+
ACs
doi:10.1038/s41598-020-66092-9
+
-
@@ -11784,10 +11397,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -12165,15 +11776,15 @@ radial glial cells acting as neural progenitors throughout life.
RGC
doi:10.1038/s41598-020-66092-9
-
+
RGCs
doi:10.1038/s41598-020-66092-9
+
-
@@ -12209,15 +11820,15 @@ radial glial cells acting as neural progenitors throughout life.
HC
doi:10.1038/s41598-020-66092-9
-
+
HCs
doi:10.1038/s41598-020-66092-9
+
-
@@ -12282,23 +11893,23 @@ radial glial cells acting as neural progenitors throughout life.
BC
doi:10.1038/s41598-020-66092-9
-
+
BCs
doi:10.1038/s41598-020-66092-9
+
-
BPs
GSE137537
+
-
@@ -12536,6 +12147,12 @@ radial glial cells acting as neural progenitors throughout life.
erythroblast
+
+
+
+
+ true
+
@@ -12544,12 +12161,6 @@ radial glial cells acting as neural progenitors throughout life.
ISBN:0721601464
PMID:18174176
-
-
-
-
- true
-
@@ -13240,13 +12851,11 @@ radial glial cells acting as neural progenitors throughout life.
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -13659,8 +13268,6 @@ radial glial cells acting as neural progenitors throughout life.
Any muscle cell in which the fibers are not organised into sarcomeres.
-
-
non-striated muscle cell
@@ -13739,7 +13346,9 @@ radial glial cells acting as neural progenitors throughout life.
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -14476,35 +14085,6 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Any process that modulates levels of neurotransmitter.
- biological_process
- GO:0001505
- regulation of neurotransmitter levels
-
-
-
-
- Any process that modulates levels of neurotransmitter.
- GOC:jl
-
-
-
-
@@ -15244,32 +14824,32 @@ plexiform layer.
-
-
+
+
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -15966,24 +15546,7 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0006866
biological_process
@@ -16445,7 +16008,6 @@ plexiform layer.
-
@@ -20004,8 +19566,8 @@ plexiform layer.
https://github.com/geneontology/go-ontology/issues/21881
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
- biological condensate
cellular_component
+ biological condensate
GO:0043228
non-membrane-bounded organelle
@@ -20756,25 +20318,9 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
+ https://github.com/geneontology/go-ontology/issues/25943
Wikipedia:Organogenesis
development of an organ
organogenesis
@@ -21460,9 +21006,11 @@ plexiform layer.
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
+ https://github.com/geneontology/go-ontology/issues/24200
establishment of localisation
biological_process
GO:0051234
+
@@ -22377,24 +21925,7 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
mah
2010-03-08T03:32:18Z
@@ -23431,14 +22962,15 @@ plexiform layer.
-
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
+ https://github.com/geneontology/go-ontology/issues/24200
kmv
2019-08-12T18:01:37Z
cellular_component
GO:0110165
+
cellular anatomical entity
@@ -23686,25 +23218,8 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
@@ -24680,9 +24195,7 @@ plexiform layer.
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
- trait
quality
PATO:0000001
quality
@@ -24693,12 +24206,6 @@ plexiform layer.
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
PATOC:GVG
-
-
-
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
- PATOC:GVG
-
@@ -24794,28 +24301,6 @@ plexiform layer.
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- quality
- PATO:0000125
-
-
-
- For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
- mass
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- PATOC:GVG
-
-
-
-
@@ -25117,7 +24602,6 @@ plexiform layer.
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
- multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
@@ -25952,27 +25436,6 @@ plexiform layer.
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
-
- 2014-12-12T08:41:11Z
- quality
- PATO:0010000
- What counts as maximally connected may be relative to some specification of granularity.
- maximally connected
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
- GOC:dos
-
-
-
-
@@ -27300,7 +26763,7 @@ plexiform layer.
-
+
@@ -27341,14 +26804,14 @@ plexiform layer.
camera-type eye
-
+
-
+
definitional
@@ -27992,7 +27455,6 @@ plexiform layer.
-
@@ -28449,7 +27911,7 @@ plexiform layer.
-
+
The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)
@@ -28474,7 +27936,7 @@ plexiform layer.
external ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png
-
+
@@ -28487,7 +27949,7 @@ plexiform layer.
-
+
EHDAA2
@@ -28856,7 +28318,7 @@ plexiform layer.
-
+
@@ -28892,14 +28354,14 @@ plexiform layer.
gastrula stage
-
+
-
+
BILS
@@ -29165,7 +28627,7 @@ plexiform layer.
-
+
@@ -29238,7 +28700,7 @@ plexiform layer.
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -29251,7 +28713,7 @@ plexiform layer.
-
+
exceptions in some taxa
@@ -29376,15 +28838,15 @@ plexiform layer.
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -29426,34 +28888,34 @@ plexiform layer.
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
-
+
Bgee:AN
@@ -29757,7 +29219,7 @@ plexiform layer.
-
+
@@ -29799,14 +29261,14 @@ plexiform layer.
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -31139,7 +30601,7 @@ plexiform layer.
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -31177,14 +30639,14 @@ plexiform layer.
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -31237,7 +30699,7 @@ plexiform layer.
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -31274,14 +30736,14 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -31326,7 +30788,7 @@ plexiform layer.
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -31371,7 +30833,7 @@ plexiform layer.
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -31384,7 +30846,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -31606,7 +31068,7 @@ plexiform layer.
-
+
@@ -31672,14 +31134,14 @@ plexiform layer.
cranial nerve II
-
+
-
+
EHDAA2
@@ -31823,7 +31285,7 @@ plexiform layer.
-
+
@@ -31900,14 +31362,14 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb
-
+
-
+
MA
@@ -31985,7 +31447,7 @@ plexiform layer.
-
+
@@ -32010,7 +31472,7 @@ plexiform layer.
-
+
The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
requires review for applicability to invertebrate structures, e.g. synganglion
@@ -32073,11 +31535,11 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb
-
+
-
+
@@ -32090,13 +31552,13 @@ plexiform layer.
-
+
FMA
-
+
Bgee:AN
@@ -32397,9 +31859,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -32424,7 +31886,7 @@ plexiform layer.
-
+
@@ -32480,44 +31942,44 @@ plexiform layer.
cornea
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
-
+
-
+
MA
-
+
MA
-
+
FMA-isa
-
+
definitional
@@ -32706,10 +32168,10 @@ plexiform layer.
-
-
-
-
+
+
+
+
The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
@@ -32760,44 +32222,44 @@ plexiform layer.
retina
http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png
-
+
-
+
-
+
-
+
-
+
FMA
-
+
FMA
-
+
FMA
-
+
EHDAA2
@@ -32871,8 +32333,8 @@ plexiform layer.
-
-
+
+
@@ -32908,24 +32370,24 @@ plexiform layer.
eye
-
+
-
+
-
+
PMID:21062451
-
+
PMID:21062451
@@ -33530,7 +32992,7 @@ plexiform layer.
-
+
@@ -33583,14 +33045,14 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -33678,7 +33140,7 @@ plexiform layer.
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -33725,7 +33187,7 @@ plexiform layer.
central nervous system
-
+
@@ -33739,7 +33201,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -34486,7 +33948,7 @@ plexiform layer.
-
+
Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
AEO:0000111
BTO:0002422
@@ -34511,14 +33973,14 @@ plexiform layer.
mesothelium
http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg
-
+
-
+
FMA
@@ -34891,7 +34353,7 @@ plexiform layer.
-
+
A tube extending from the mouth to the anus.
@@ -34931,14 +34393,14 @@ plexiform layer.
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -35018,7 +34480,7 @@ plexiform layer.
-
+
The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].
BTO:0000654
@@ -35041,7 +34503,7 @@ plexiform layer.
ciliary muscle
http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png
-
+
@@ -35060,7 +34522,7 @@ plexiform layer.
-
+
FMA
@@ -35201,7 +34663,7 @@ plexiform layer.
-
+
@@ -35253,14 +34715,14 @@ plexiform layer.
eyelid
https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg
-
+
-
+
multiple
@@ -35555,7 +35017,7 @@ plexiform layer.
-
+
@@ -35598,14 +35060,14 @@ plexiform layer.
iris
-
+
-
+
XAO
@@ -35677,7 +35139,7 @@ plexiform layer.
-
+
@@ -35729,14 +35191,14 @@ plexiform layer.
corneal epithelium
http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png
-
+
-
+
ISBN:0781772214
@@ -35832,16 +35294,16 @@ plexiform layer.
-
-
+
+
-
-
+
+
@@ -35883,44 +35345,44 @@ plexiform layer.
sclera
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
-
+
-
+
FMA
-
+
ZFA
-
+
ISBN:0781772214
-
+
cjm
ISBN:0781772214
Wikipedia
@@ -35980,7 +35442,7 @@ plexiform layer.
-
+
@@ -36019,14 +35481,14 @@ plexiform layer.
ciliary body
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
ISBN:0781772214
@@ -36074,14 +35536,14 @@ plexiform layer.
-
+
-
+
@@ -36144,24 +35606,24 @@ plexiform layer.
optic choroid
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
MA
-
+
Wikipedia
@@ -36261,7 +35723,7 @@ plexiform layer.
-
+
@@ -36310,14 +35772,14 @@ plexiform layer.
substantia propria of cornea
http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png
-
+
-
+
cjm
ISBN:0781772214
Wikipedia
@@ -36394,9 +35856,9 @@ plexiform layer.
-
-
-
+
+
+
A double layer covering the ciliary body that produces aqueous humor.
BTO:0001770
@@ -36416,15 +35878,15 @@ plexiform layer.
ciliary epithelium
-
+
-
+
-
+
@@ -36437,19 +35899,19 @@ plexiform layer.
-
+
MA
-
+
MP
-
+
Wikipedia
@@ -36572,7 +36034,7 @@ plexiform layer.
-
+
@@ -36633,14 +36095,14 @@ plexiform layer.
pigmented layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
-
+
Wikipedia
@@ -36744,7 +36206,7 @@ plexiform layer.
-
+
@@ -36778,14 +36240,14 @@ plexiform layer.
photoreceptor layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
-
+
ZFA
@@ -36958,7 +36420,7 @@ plexiform layer.
-
+
@@ -37005,14 +36467,14 @@ plexiform layer.
outer nuclear layer of retina
-
+
-
+
soma
ZFA
@@ -37350,7 +36812,7 @@ plexiform layer.
-
+
@@ -37409,7 +36871,7 @@ plexiform layer.
ganglionic layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
@@ -37422,7 +36884,7 @@ plexiform layer.
-
+
FMA
@@ -37498,7 +36960,7 @@ plexiform layer.
-
+
@@ -37554,14 +37016,14 @@ plexiform layer.
nerve fiber layer of retina
-
+
-
+
FMA
@@ -37939,7 +37401,7 @@ plexiform layer.
-
+
@@ -37975,14 +37437,14 @@ plexiform layer.
aqueous humor of eyeball
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
FMA def states A and P
located_in in EHDAA2
VHOG
@@ -38164,7 +37626,7 @@ plexiform layer.
-
+
@@ -38188,7 +37650,7 @@ plexiform layer.
vitreous body
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
@@ -38201,7 +37663,7 @@ plexiform layer.
-
+
neural ectoderm of optic cup
ISBN:0781772214
@@ -38336,8 +37798,8 @@ plexiform layer.
-
-
+
+
@@ -38370,24 +37832,24 @@ plexiform layer.
anterior segment of eyeball
http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png
-
+
-
+
-
+
FMA
-
+
cjm
@@ -38438,8 +37900,8 @@ plexiform layer.
-
-
+
+
@@ -38469,24 +37931,24 @@ plexiform layer.
posterior segment of eyeball
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
FMA
-
+
cjm
@@ -38522,9 +37984,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -38574,15 +38036,15 @@ plexiform layer.
conjunctiva
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png
-
+
-
+
-
+
@@ -38595,19 +38057,19 @@ plexiform layer.
-
+
cjm
-
+
MA
-
+
ISBN:0781772214
@@ -38671,7 +38133,7 @@ plexiform layer.
-
+
The most anterior region of the brain including both the telencephalon and diencephalon.
@@ -38718,14 +38180,14 @@ plexiform layer.
forebrain
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
definitional
@@ -38801,14 +38263,14 @@ plexiform layer.
-
+
-
+
The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].
developmental relationships need revised
@@ -38861,24 +38323,24 @@ plexiform layer.
midbrain
http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG
-
+
-
+
-
+
definitional
-
+
Bgee:AN
@@ -38981,14 +38443,14 @@ plexiform layer.
-
+
-
+
The division of the forebrain that develops from the foremost primary cerebral vesicle.
@@ -39051,24 +38513,24 @@ plexiform layer.
diencephalon
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
-
+
definitional
-
+
definitional
@@ -39506,7 +38968,7 @@ plexiform layer.
-
+
Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].
Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]
@@ -39546,14 +39008,14 @@ plexiform layer.
midbrain tegmentum
http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png
-
+
-
+
ZFA
@@ -39732,8 +39194,8 @@ plexiform layer.
-
-
+
+
@@ -39746,7 +39208,7 @@ plexiform layer.
-
+
@@ -39803,34 +39265,34 @@ plexiform layer.
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
-
+
-
+
-
+
-
+
AEO
-
+
EHDAA2
-
+
GO:0072360
@@ -40189,7 +39651,7 @@ plexiform layer.
-
+
@@ -40202,7 +39664,7 @@ plexiform layer.
-
+
The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].
@@ -40253,25 +39715,25 @@ plexiform layer.
hindbrain
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
-
+
modified-source-relation
ABA
-
+
Bgee:AN
@@ -41090,7 +40552,7 @@ plexiform layer.
-
+
Vasculature that is part of the eye region.
not part of the eye in ZFA. Note this changed to a blood vessel in ZFA
@@ -41113,14 +40575,14 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb
-
+
-
+
ISBN:0781772214
@@ -41179,7 +40641,7 @@ plexiform layer.
-
+
@@ -41213,14 +40675,14 @@ plexiform layer.
musculoskeletal system
-
+
-
+
check ctenophore
@@ -41358,15 +40820,15 @@ plexiform layer.
-
+
-
-
+
+
Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
TODO - add superclass to unify with VNC?
@@ -41425,34 +40887,34 @@ plexiform layer.
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Spinal_Cord.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Spinal_Cord.glb
-
+
-
+
-
+
-
+
ZFA
-
+
definitional
-
+
definitional
@@ -41894,7 +41356,7 @@ plexiform layer.
-
+
@@ -41935,14 +41397,14 @@ plexiform layer.
coelemic cavity lumen
-
+
-
+
definitional
@@ -42050,9 +41512,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -42107,15 +41569,15 @@ plexiform layer.
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -42134,19 +41596,19 @@ plexiform layer.
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -42231,8 +41693,8 @@ plexiform layer.
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -42278,11 +41740,11 @@ plexiform layer.
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -42295,13 +41757,13 @@ plexiform layer.
-
+
GOTAX:0000352
-
+
ZFA
@@ -42414,12 +41876,12 @@ plexiform layer.
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -42459,66 +41921,66 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -42901,14 +42363,14 @@ plexiform layer.
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -42951,24 +42413,24 @@ plexiform layer.
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -43033,8 +42495,8 @@ plexiform layer.
-
-
+
+
@@ -43060,11 +42522,11 @@ plexiform layer.
iris epithelium
-
+
-
+
@@ -43077,13 +42539,13 @@ plexiform layer.
-
+
MA
-
+
MP
@@ -43233,7 +42695,7 @@ plexiform layer.
-
+
Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.
Do not merge with neurogenic placode
Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons
@@ -43253,7 +42715,7 @@ plexiform layer.
cranial placode
-
+
@@ -43266,7 +42728,7 @@ plexiform layer.
-
+
PMID:11523831
PMID:22512454
@@ -43471,7 +42933,7 @@ plexiform layer.
-
+
@@ -43484,7 +42946,7 @@ plexiform layer.
-
+
The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.
consider adding class for organizer. Consider adding separate class for isthmus as a structure
Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG]
@@ -43514,11 +42976,11 @@ plexiform layer.
midbrain-hindbrain boundary
-
+
-
+
@@ -43532,13 +42994,13 @@ plexiform layer.
-
+
ZFA
-
+
ZFA
@@ -43703,7 +43165,7 @@ plexiform layer.
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -43728,14 +43190,14 @@ plexiform layer.
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -43977,7 +43439,7 @@ plexiform layer.
-
+
@@ -44015,7 +43477,7 @@ plexiform layer.
eye primordium
-
+
@@ -44028,7 +43490,7 @@ plexiform layer.
-
+
PMID:16496288
XAO
@@ -44084,8 +43546,8 @@ plexiform layer.
-
-
+
+
@@ -44114,24 +43576,24 @@ plexiform layer.
optic cup
-
+
-
+
-
+
ZFA
-
+
ZFA
@@ -44196,7 +43658,7 @@ plexiform layer.
-
+
@@ -44237,7 +43699,7 @@ plexiform layer.
lens placode
http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png
-
+
@@ -44250,7 +43712,7 @@ plexiform layer.
-
+
ZFA
@@ -44314,9 +43776,9 @@ plexiform layer.
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -44348,34 +43810,34 @@ plexiform layer.
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -44486,7 +43948,7 @@ plexiform layer.
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -44515,7 +43977,7 @@ plexiform layer.
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -44528,7 +43990,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -44640,7 +44102,7 @@ plexiform layer.
-
+
@@ -44684,7 +44146,7 @@ plexiform layer.
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -44697,7 +44159,7 @@ plexiform layer.
-
+
EHDAA2
VHOG
@@ -44781,15 +44243,15 @@ plexiform layer.
-
-
+
+
-
+
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
@@ -44809,15 +44271,15 @@ plexiform layer.
heart primordium
-
+
-
+
-
+
@@ -44830,19 +44292,19 @@ plexiform layer.
-
+
ZFA
-
+
ZFA
-
+
XAO
@@ -44897,8 +44359,8 @@ plexiform layer.
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -44925,11 +44387,11 @@ plexiform layer.
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -44948,13 +44410,13 @@ plexiform layer.
-
+
VHOG:0000680
-
+
ZFA
@@ -45372,7 +44834,7 @@ plexiform layer.
-
+
Mesenchyme that is part of a developing camera-type eye.
TODO - change mesenchyme relationships to precursor_of
EHDAA2:0000485
@@ -45384,14 +44846,14 @@ plexiform layer.
UBERON:0003314
eye mesenchyme
-
+
-
+
EHDAA2
@@ -46249,7 +45711,7 @@ plexiform layer.
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -46265,14 +45727,14 @@ plexiform layer.
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -46377,7 +45839,7 @@ plexiform layer.
-
+
The part of the retina that contains neurons and photoreceptor cells[GO].
(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]
@@ -46409,14 +45871,14 @@ plexiform layer.
retinal neural layer
-
+
-
+
Bgee:AN
@@ -46674,7 +46136,7 @@ plexiform layer.
-
+
The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.
consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure
The layer of undifferentiated, proliferating cells that line the neural tube lumen
@@ -46692,7 +46154,7 @@ plexiform layer.
neural tube ventricular layer
-
+
@@ -46705,7 +46167,7 @@ plexiform layer.
-
+
NCBIBook:NBK10047
@@ -46765,7 +46227,7 @@ plexiform layer.
-
+
@@ -46789,7 +46251,7 @@ plexiform layer.
neural tube mantle layer
-
+
@@ -46802,7 +46264,7 @@ plexiform layer.
-
+
by division
NCBIBook:NBK10047
@@ -46839,7 +46301,7 @@ plexiform layer.
-
+
@@ -46856,14 +46318,14 @@ plexiform layer.
neural tube marginal layer
-
+
-
+
forms from axons
@@ -47138,9 +46600,9 @@ plexiform layer.
-
-
-
+
+
+
@@ -47173,34 +46635,34 @@ plexiform layer.
optic vesicle
http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png
-
+
-
+
-
+
-
+
ZFA
-
+
GO-def
-
+
ZFA
@@ -47316,8 +46778,8 @@ plexiform layer.
-
-
+
+
A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
@@ -47330,24 +46792,24 @@ plexiform layer.
UBERON:0004140
primary heart field
-
+
-
+
-
+
GO:0003128
-
+
https://orcid.org/0000-0003-3308-6245
@@ -47406,7 +46868,7 @@ plexiform layer.
-
+
An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
@@ -47426,14 +46888,14 @@ plexiform layer.
heart tube
-
+
-
+
ZFA-modified
@@ -47514,7 +46976,7 @@ plexiform layer.
-
+
@@ -47530,14 +46992,14 @@ plexiform layer.
eye muscle
-
+
-
+
MA
@@ -47741,7 +47203,7 @@ plexiform layer.
-
+
A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].
Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN]
@@ -47771,14 +47233,14 @@ plexiform layer.
Descemet's membrane
https://github.com/obophenotype/uberon/issues/15
-
+
-
+
Cline et al
@@ -48561,7 +48023,7 @@ plexiform layer.
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -48577,14 +48039,14 @@ plexiform layer.
skeletal element
-
+
-
+
VSAO
@@ -48629,7 +48091,7 @@ plexiform layer.
-
+
@@ -48668,14 +48130,14 @@ plexiform layer.
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -49582,7 +49044,7 @@ plexiform layer.
-
+
Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.
Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO]
EFO:0003492
@@ -49604,14 +49066,14 @@ plexiform layer.
head mesenchyme
-
+
-
+
EHDAA2
@@ -49678,7 +49140,7 @@ plexiform layer.
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -49694,14 +49156,14 @@ plexiform layer.
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -49724,7 +49186,7 @@ plexiform layer.
-
+
The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].
The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]
@@ -49749,14 +49211,14 @@ plexiform layer.
myelencephalon
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
definitional
@@ -50283,7 +49745,7 @@ plexiform layer.
-
+
Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.
TAO:0002188
ZFA:0001688
@@ -50291,7 +49753,7 @@ plexiform layer.
UBERON:0005427
corneal primordium
-
+
@@ -50310,7 +49772,7 @@ plexiform layer.
-
+
ZFA
@@ -50333,7 +49795,7 @@ plexiform layer.
-
+
Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
@@ -50351,14 +49813,14 @@ plexiform layer.
primitive heart tube
-
+
-
+
ZFA
@@ -50561,7 +50023,7 @@ plexiform layer.
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -50571,7 +50033,7 @@ plexiform layer.
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -50590,7 +50052,7 @@ plexiform layer.
-
+
AEO-modified-relation
@@ -50649,9 +50111,9 @@ plexiform layer.
-
-
-
+
+
+
A serous sac which is the aggregate of the conjunctiva plus the conjunctival space.
EMAPA:18233
FMA:20291
@@ -50662,15 +50124,15 @@ plexiform layer.
UBERON:0005908
conjunctival sac
-
+
-
+
-
+
@@ -50683,19 +50145,19 @@ plexiform layer.
-
+
FMA
-
+
HPO:pr
-
+
MA
@@ -50950,7 +50412,7 @@ plexiform layer.
-
+
@@ -50973,14 +50435,14 @@ plexiform layer.
future diencephalon
-
+
-
+
EHDAA2
@@ -51163,7 +50625,7 @@ plexiform layer.
-
+
@@ -51187,14 +50649,14 @@ plexiform layer.
future spinal cord
-
+
-
+
EHDAA2
@@ -51231,7 +50693,7 @@ plexiform layer.
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -51246,7 +50708,7 @@ plexiform layer.
notochordal plate
-
+
@@ -51259,7 +50721,7 @@ plexiform layer.
-
+
EHDAA2
@@ -51296,7 +50758,7 @@ plexiform layer.
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -51313,14 +50775,14 @@ plexiform layer.
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -52225,7 +51687,7 @@ plexiform layer.
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -52240,14 +51702,14 @@ plexiform layer.
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -52402,8 +51864,8 @@ plexiform layer.
-
-
+
+
@@ -52430,24 +51892,24 @@ plexiform layer.
presumptive hindbrain
-
+
-
+
-
+
XAO-abduced
-
+
cjm
@@ -52504,7 +51966,7 @@ plexiform layer.
-
+
@@ -52523,14 +51985,14 @@ plexiform layer.
presumptive midbrain hindbrain boundary
-
+
-
+
ZFA
@@ -52569,7 +52031,7 @@ plexiform layer.
-
+
@@ -52586,14 +52048,14 @@ plexiform layer.
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -52692,7 +52154,7 @@ plexiform layer.
-
+
@@ -52718,7 +52180,7 @@ plexiform layer.
presumptive paraxial mesoderm
-
+
@@ -52734,7 +52196,7 @@ plexiform layer.
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -52816,7 +52278,7 @@ plexiform layer.
-
+
A neural decussation that is part of a diencephalon.
FMA:62446
diencephalon decussation
@@ -52824,7 +52286,7 @@ plexiform layer.
UBERON:0007425
decussation of diencephalon
-
+
@@ -52837,7 +52299,7 @@ plexiform layer.
-
+
Obol
@@ -52912,7 +52374,7 @@ plexiform layer.
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -52920,7 +52382,7 @@ plexiform layer.
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -52933,7 +52395,7 @@ plexiform layer.
-
+
AEO
@@ -53173,7 +52635,7 @@ plexiform layer.
-
+
An axon tract that is part of a brain.
the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts
FMA:83848
@@ -53183,14 +52645,14 @@ plexiform layer.
UBERON:0007702
tract of brain
-
+
-
+
cjm
@@ -53218,7 +52680,7 @@ plexiform layer.
-
+
Anatomical system that consists of all blood and lymph vessels.
consider merging with vasculature
The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
@@ -53235,14 +52697,14 @@ plexiform layer.
vascular system
-
+
-
+
MA
@@ -53375,7 +52837,7 @@ plexiform layer.
-
+
@@ -53392,14 +52854,14 @@ plexiform layer.
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -53495,8 +52957,8 @@ plexiform layer.
-
-
+
+
TODO - developmental relationships for lines
TAO:0007044
ZFA:0007044
@@ -53506,24 +52968,24 @@ plexiform layer.
UBERON:0009615
midbrain hindbrain boundary neural plate
-
+
-
+
-
+
ZFA
-
+
https://github.com/obophenotype/uberon/issues/438
Bgee:AN
@@ -53557,14 +53019,14 @@ plexiform layer.
-
+
-
+
@@ -53589,24 +53051,24 @@ plexiform layer.
presumptive midbrain
-
+
-
+
-
+
ZFA
-
+
ZFA
@@ -53652,7 +53114,7 @@ plexiform layer.
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -53660,14 +53122,14 @@ plexiform layer.
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -53689,7 +53151,7 @@ plexiform layer.
-
+
EFO:0003704
TAO:0005041
ZFA:0005041
@@ -53699,14 +53161,14 @@ plexiform layer.
anterior lateral plate mesoderm
-
+
-
+
ZFA
@@ -53762,14 +53224,14 @@ plexiform layer.
-
+
EHDAA2:0001315
EHDAA:1122
uberon
UBERON:0009920
optic neural crest
-
+
@@ -53782,7 +53244,7 @@ plexiform layer.
-
+
EHDAA2
@@ -53916,7 +53378,7 @@ plexiform layer.
-
+
@@ -53941,14 +53403,14 @@ plexiform layer.
eyeball of camera-type eye
-
+
-
+
FMA
@@ -53989,8 +53451,8 @@ plexiform layer.
-
-
+
+
Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.
DHBA:12322
EFO:0003567
@@ -54004,11 +53466,11 @@ plexiform layer.
midbrain basal plate
-
+
-
+
@@ -54021,13 +53483,13 @@ plexiform layer.
-
+
EHDAA2
-
+
ZFA
@@ -54055,7 +53517,7 @@ plexiform layer.
-
+
Portion of neural tube that gives rise to the midbrain.
we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed
TAO:0007039
@@ -54064,14 +53526,14 @@ plexiform layer.
UBERON:0010286
midbrain neural tube
-
+
-
+
ZFA
@@ -54098,7 +53560,7 @@ plexiform layer.
-
+
@@ -54114,14 +53576,14 @@ plexiform layer.
UBERON:0010312
immature eye
-
+
-
+
definitional
@@ -54399,8 +53861,8 @@ plexiform layer.
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -54413,11 +53875,11 @@ plexiform layer.
subdivision of skeleton
-
+
-
+
@@ -54430,13 +53892,13 @@ plexiform layer.
-
+
UBERONREF:0000003
-
+
VSAO
@@ -54513,7 +53975,7 @@ plexiform layer.
-
+
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
axial skeletal system
FMA:302077
@@ -54523,7 +53985,7 @@ plexiform layer.
postcranial axial skeletal system
http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton
-
+
@@ -54536,7 +53998,7 @@ plexiform layer.
-
+
cjm
@@ -54648,7 +54110,7 @@ plexiform layer.
-
+
Muscles within the eye (bulbus oculi).[AAO]
AAO:0010038
EMAPA:18808
@@ -54659,14 +54121,14 @@ plexiform layer.
UBERON:0011222
intra-ocular muscle
-
+
-
+
EMAPA
@@ -54936,7 +54398,7 @@ plexiform layer.
-
+
@@ -54978,7 +54440,7 @@ plexiform layer.
anterior uvea
-
+
@@ -54991,7 +54453,7 @@ plexiform layer.
-
+
MP
@@ -55767,7 +55229,7 @@ plexiform layer.
-
+
@@ -55790,7 +55252,7 @@ plexiform layer.
UBERON:0016887
entire extraembryonic component
-
+
@@ -55803,7 +55265,7 @@ plexiform layer.
-
+
AEO
@@ -56766,48 +56228,6 @@ plexiform layer.
///////////////////////////////////////////////////////////////////////////////////////
-->
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Should belong in BFO, but lives in caro for now.
-
-
-
-
-
@@ -56838,16 +56258,6 @@ plexiform layer.
-
-
-
-
-
-
-
-
-
-
@@ -57698,5 +57108,5 @@ plexiform layer.
-
+
diff --git a/subsets/eye_upper_slim.tsv b/subsets/eye_upper_slim.tsv
index 163ff253e..f0cd17a94 100644
--- a/subsets/eye_upper_slim.tsv
+++ b/subsets/eye_upper_slim.tsv
@@ -1,332 +1,323 @@
?x ?label
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1005
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1054
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1062
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1069
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1076
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1082
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1092
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1107
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1113
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1120
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1126
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1132
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1139
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1146
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1153
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1162
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1174
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1182
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1187
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1193
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1199
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1207
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1213
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1219
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid122
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1225
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1231
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1237
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1245
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid125
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1253
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1262
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1270
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1278
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1291
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1298
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1305
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1312
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1320
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1331
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1339
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1348
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1355
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1423
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1436
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1444
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1469
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1479
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1485
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1491
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1497
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1508
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1531
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1542
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1552
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1564
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1573
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1582
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1593
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1599
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1607
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1613
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1619
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1625
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1635
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1644
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1651
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1659
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1667
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1673
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1680
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1686
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1696
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1716
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1728
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1741
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1750
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1760
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1769
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1777
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1799
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1810
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1825
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1832
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1838
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1844
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1849
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1854
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1860
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1866
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1873
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1879
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid19
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1900
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1906
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1912
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1919
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1927
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1939
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1946
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1953
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1961
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1972
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1978
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1984
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid1993
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2000
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2011
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2017
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2029
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2043
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2056
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2062
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2074
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2081
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2086
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2098
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2104
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2110
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2127
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2135
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2151
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2157
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2163
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2175
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2187
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2196
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2203
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2209
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2217
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2226
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2236
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2246
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2252
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2259
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2265
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2271
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2280
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2290
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2296
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2303
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2370
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2415
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2421
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2507
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2514
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2521
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2550
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2566
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2634
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2671
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2711
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2753
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2760
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2769
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2838
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2850
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2860
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2873
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2882
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2943
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid2972
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3012
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3018
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3108
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3124
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3222
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3238
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3254
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3308
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid335
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3367
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid343
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3434
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3451
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3473
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid349
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3602
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3657
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid366
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid37
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid372
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3801
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid382
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3839
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3851
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid389
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3894
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3909
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3948
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3960
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid3982
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4144
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4168
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4207
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4221
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4247
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4279
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4306
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid440
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4414
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4426
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4435
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4443
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4456
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4474
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4490
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4503
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4513
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4524
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4536
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4545
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4565
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid457
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4582
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4587
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid46
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4640
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4654
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4661
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4707
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4726
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid474
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4750
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4775
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4791
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4798
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4812
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4819
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4827
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid484
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4851
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4865
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4889
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid493
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4931
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4939
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4947
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4955
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4963
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4975
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid499
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4992
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid4999
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5014
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5029
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5066
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5118
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5126
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5143
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5172
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5188
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5198
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5208
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5213
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5222
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5233
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5243
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5251
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5277
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5286
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid529
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5296
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5311
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5319
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5335
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5345
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5354
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5365
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid538
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5380
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5397
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5407
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5420
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5455
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5468
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5491
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5500
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5508
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid551
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5536
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5545
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5551
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5558
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid559
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5594
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5611
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5620
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5653
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5667
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid569
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5693
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5701
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5715
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5721
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5729
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5748
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5754
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5759
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5765
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid581
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5826
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid5830
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid599
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid604
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid611
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid622
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid629
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid63
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid637
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid644
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid650
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid662
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid715
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid732
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid752
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid767
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid822
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid872
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid889
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid902
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid907
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid916
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid922
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid936
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid942
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid950
-_:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1018
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1026
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1033
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1040
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1046
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1056
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1071
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1077
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1084
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1090
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1096
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1103
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1110
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1117
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1126
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1138
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1146
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1151
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1157
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid116
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1163
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1171
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1177
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1183
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1189
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid119
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1195
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1201
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1209
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1217
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1226
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1234
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1242
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1252
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1259
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1266
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1273
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1281
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1292
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1300
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1309
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1316
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1392
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1400
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1425
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1435
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1441
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1447
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1453
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1464
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1487
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1498
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1508
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1520
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1529
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1538
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1549
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1555
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1563
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1569
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1575
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1581
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1591
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1600
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1607
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1615
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1623
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1629
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1636
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1642
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1652
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1672
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1684
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1697
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1706
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1716
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1725
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1733
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1755
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1766
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1781
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1788
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1794
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1800
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1805
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1810
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1816
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1822
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1829
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1835
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1856
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1862
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1868
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1875
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1890
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1897
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid19
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1904
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1912
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1923
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1929
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1935
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1944
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1951
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1962
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1968
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1980
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid1994
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2007
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2013
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2025
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2032
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2037
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2049
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2056
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2073
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2081
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2097
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2103
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2109
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2121
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2133
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2142
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2149
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2155
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2163
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2172
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2182
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2192
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2198
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2205
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2211
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2217
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2231
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2237
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2244
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2309
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2354
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2360
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2445
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2452
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2459
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2488
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2504
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2572
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2609
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2649
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2691
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2698
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2707
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2776
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2788
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2798
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2811
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2820
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2881
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2910
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2950
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid2956
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3046
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3062
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3160
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3176
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3192
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3246
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid330
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3305
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid336
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3372
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3389
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3411
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid346
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid35
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid353
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3540
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3595
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3739
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3777
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3789
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3832
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3847
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3886
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3898
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid3920
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid404
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4082
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4106
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4145
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4159
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4185
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid421
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4217
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4244
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid43
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4352
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4364
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4373
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid438
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4381
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4394
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4412
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4428
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4441
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4451
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4462
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4474
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid448
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4483
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4503
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4520
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4525
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid457
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4578
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4592
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4599
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid463
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4645
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4664
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4688
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4713
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4729
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4736
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4750
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4757
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4765
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4789
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4803
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4827
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4869
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4877
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4885
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4893
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4901
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4913
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid493
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4930
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4937
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4952
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid4967
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5004
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid502
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5056
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5064
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5081
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5110
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5126
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5136
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5146
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid515
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5151
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5160
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5171
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5181
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5189
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5215
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5224
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid523
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5234
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5249
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5257
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5273
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5283
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5292
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5303
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5318
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid533
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5335
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5345
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5358
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5393
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5406
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5429
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5438
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5446
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid545
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5474
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5483
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5489
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5496
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5532
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5549
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5558
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5591
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5605
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid563
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5631
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5639
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5653
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5659
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5667
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid568
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5686
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5692
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5697
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid5703
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid575
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid58
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid586
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid593
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid601
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid608
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid614
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid626
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid679
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid696
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid716
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid731
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid786
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid836
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid853
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid866
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid871
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid880
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid886
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid900
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid906
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid914
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid922
+_:Bebedf232X2D7b58X2D47a3X2D8e89X2D0e48210fc6e4genid969
"continuant"
"occurrent"
"independent continuant"
@@ -334,17 +325,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"specifically dependent continuant"
"material entity"
"immaterial entity"
- "anatomical entity"
- "connected anatomical structure"
- "material anatomical entity"
- "multicellular organism"
- "gross anatomical part"
- "organism"
- "multicellular anatomical structure"
- "cellular organism"
- "biological entity"
-
-
"cell"
"fibroblast neural crest derived"
"neuronal receptor cell"
@@ -495,7 +475,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"nuclear division"
"chromatin"
"heterochromatin"
- "regulation of neurotransmitter levels"
"action potential"
"formation of translation initiation ternary complex"
"formation of primary germ layer"
@@ -799,7 +778,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"qualitative"
"deviation (from_normal)"
"size"
- "mass"
"closure"
"structure"
"branched"
@@ -850,7 +828,6 @@ _:Bf1a00943X2D7595X2D47fcX2Dba2eX2D7f30d218392fgenid958
"superelliptic"
"acidophilic"
"nucleated"
- "maximally connected"
"disconnected"
"cell morphology"
"polymeric"
diff --git a/subsets/general_cell_types_upper_slim.json b/subsets/general_cell_types_upper_slim.json
index ccee65351..928860897 100644
--- a/subsets/general_cell_types_upper_slim.json
+++ b/subsets/general_cell_types_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-09-21"
+ "val" : "2023-10-19"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-09-21/subsets/general_cell_types_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-10-19/subsets/general_cell_types_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -296,9 +296,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "occurs_in"
@@ -724,168 +721,6 @@
"val" : "in_dorsal_side_of"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "lbl" : "anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
- "xrefs" : [ "CAROC:Brownsville2014" ]
- },
- "comments" : [ "Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "lbl" : "connected anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome."
- },
- "comments" : [ "Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "lbl" : "material anatomical entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical entity that has mass."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "lbl" : "multicellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell."
- },
- "comments" : [ "MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "lbl" : "gross anatomical part",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. "
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#plus" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "10.7.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "lbl" : "organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Material anatomical entity that is a member of an individual species or is a viral or viroid particle."
- },
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "organism or virus or viroid"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "Melissa Haendel"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "9/18/11"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "lbl" : "multicellular anatomical structure",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An anatomical structure that has more than one cell as a part."
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/caro#core" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "djs93"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "Sun Feb 27 10:53:00 GMT 2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "lbl" : "cellular organism",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "An individual member of a clade of cellular organisms."
- },
- "comments" : [ "A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms. " ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
- "val" : "https://orcid.org/0000-0001-9114-8737"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_creation_date",
- "val" : "7.16.2011"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "lbl" : "biological entity",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them."
- },
- "comments" : [ "Important for alignment with Darwin Core class \"Organism\"." ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
- }, {
- "id" : "http://purl.obolibrary.org/obo/CHEBI_50860",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "Any molecular entity that contains carbon.",
- "xrefs" : [ "ANON:ANON" ]
- },
- "synonyms" : [ {
- "pred" : "hasRelatedSynonym",
- "val" : "organic compounds",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic entity",
- "xrefs" : [ "ChEBI:" ]
- }, {
- "pred" : "hasRelatedSynonym",
- "val" : "organic molecular entities",
- "xrefs" : [ "ChEBI:" ]
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "chebi_ontology"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000000",
"lbl" : "cell",
@@ -980,7 +815,7 @@
"pred" : "hasExactSynonym",
"val" : "hemopoietic stem cell"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "HSC"
}, {
@@ -1028,7 +863,7 @@
},
"comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-M"
}, {
@@ -1088,17 +923,17 @@
"pred" : "hasExactSynonym",
"val" : "common myeloid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GEMM",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-S",
"xrefs" : [ "ISBN:0878932437" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CMP",
"xrefs" : [ "ISBN:0878932437" ]
@@ -1148,11 +983,11 @@
"pred" : "hasExactSynonym",
"val" : "common lymphoid precursor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CLP"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "ELP"
}, {
@@ -1291,7 +1126,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"
} ]
}
@@ -1489,7 +1324,7 @@
"xrefs" : [ "MESH:D009457" ]
},
"comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ],
- "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "neuroglial cell"
@@ -1505,6 +1340,10 @@
"val" : "FBbt:00005144"
}, {
"val" : "FMA:54536"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1542,15 +1381,15 @@
"val" : "marrow stromal cells",
"xrefs" : [ "PMID:11378515" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "BMSC"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-F"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "MSC",
"xrefs" : [ "PMID:11378515" ]
@@ -1631,7 +1470,7 @@
"comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ],
"subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
"synonyms" : [ {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "APC"
} ]
@@ -1705,15 +1544,10 @@
"val" : "A cell that specializes in controlled release of one or more substances.",
"xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "BTO:0003659"
}, {
"val" : "FMA:86916"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -1792,7 +1626,7 @@
"val" : "WBbt:0003675"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg"
} ]
}
@@ -1892,7 +1726,7 @@
"val" : "FMA:86740"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"
} ]
}
@@ -2395,7 +2229,7 @@
"pred" : "http://purl.obolibrary.org/obo/RO_0002175",
"val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
}, {
- "pred" : "http://xmlns.com/foaf/0.1/depicted_by",
+ "pred" : "http://xmlns.com/foaf/0.1/depiction",
"val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg"
} ]
}
@@ -2472,12 +2306,12 @@
"pred" : "hasExactSynonym",
"val" : "granulocyte/monocyte progenitor"
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "CFU-GM",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
}, {
- "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation",
+ "synonymType" : "http://purl.obolibrary.org/obo/OMO_0003000",
"pred" : "hasRelatedSynonym",
"val" : "GMP",
"xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
@@ -2518,17 +2352,12 @@
"xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
},
"comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "angioblast"
}, {
"pred" : "hasExactSynonym",
"val" : "chondroplast"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -2744,12 +2573,7 @@
"definition" : {
"val" : "A cell of the monocyte, granulocyte, or mast cell lineage.",
"xrefs" : [ "GOC:add" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0000775",
@@ -2822,7 +2646,6 @@
"xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ]
},
"comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasBroadSynonym",
"val" : "interdigitating cell"
@@ -2838,10 +2661,6 @@
} ],
"xrefs" : [ {
"val" : "BTO:0004721"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -3390,7 +3209,6 @@
"val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.",
"xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"xrefs" : [ {
"val" : "CALOHA:TS-2096"
}, {
@@ -3399,9 +3217,6 @@
"val" : "MESH:D003239"
} ],
"basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- }, {
"pred" : "http://purl.org/dc/terms/contributor",
"val" : "https://orcid.org/0000-0003-1980-3228"
}, {
@@ -3541,12 +3356,7 @@
"definition" : {
"val" : "Any muscle cell in which the fibers are not organised into sarcomeres.",
"xrefs" : [ "GOC:DOS" ]
- },
- "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
- "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
- } ]
+ }
}
}, {
"id" : "http://purl.obolibrary.org/obo/CL_0008001",
@@ -3592,9 +3402,14 @@
"definition" : {
"val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
},
+ "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "mesenchyme cell"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002175",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606"
} ]
}
}, {
@@ -8146,7 +7961,7 @@
"pred" : "hasExactSynonym",
"val" : "non-membrane-enclosed organelle"
}, {
- "pred" : "hasNarrowSynonym",
+ "pred" : "hasRelatedSynonym",
"val" : "biological condensate"
} ],
"xrefs" : [ {
@@ -8649,6 +8464,9 @@
"val" : "Wikipedia:Organogenesis"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/25943"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -8765,6 +8583,10 @@
"xrefs" : [ "GOC:ebc" ]
},
"subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "synonyms" : [ {
+ "pred" : "hasExactSynonym",
+ "val" : "tissue remodelling"
+ } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
@@ -9143,13 +8965,16 @@
"val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.",
"xrefs" : [ "GOC:ai", "GOC:dos" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"synonyms" : [ {
"pred" : "hasExactSynonym",
"val" : "establishment of localisation",
"xrefs" : [ "GOC:mah" ]
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "biological_process"
} ]
@@ -10103,8 +9928,11 @@
"val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.",
"xrefs" : [ "GOC:kmv" ]
},
- "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
+ "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/geneontology/go-ontology/issues/24200"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
"val" : "kmv"
}, {
@@ -10411,7 +10239,7 @@
"val" : "http://purl.obolibrary.org/obo/IAO_0000122"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
- "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with."
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "PERSON:Daniel Schober"
@@ -11617,6 +11445,28 @@
"val" : "https://orcid.org/0000-0002-8688-6599"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/OMO_0003000",
+ "lbl" : "abbreviation",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A synonym type for describing abbreviations or initalisms"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
+ "val" : "https://github.com/information-artifact-ontology/ontology-metadata/issues/122"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-4423-4370"
+ }, {
+ "pred" : "http://purl.org/dc/terms/created",
+ "val" : "2023-03-03"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/OMO_0003004",
"lbl" : "plural form",
@@ -11645,13 +11495,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.",
+ "val" : "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities",
"xrefs" : [ "PATOC:GVG" ]
},
- "synonyms" : [ {
- "pred" : "hasExactSynonym",
- "val" : "trait"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
"val" : "PATO:0000072"
@@ -11739,22 +11585,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "lbl" : "mass",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.",
- "xrefs" : [ "PATOC:GVG" ]
- },
- "comments" : [ "For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism." ],
- "subsets" : [ "http://purl.obolibrary.org/obo/pato#attribute_slim", "http://purl.obolibrary.org/obo/pato#relational_slim", "http://purl.obolibrary.org/obo/pato#scalar_slim" ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0000141",
"lbl" : "structure",
@@ -11934,9 +11764,6 @@
}, {
"pred" : "hasExactSynonym",
"val" : "multiply inhering quality of a physical entity"
- }, {
- "pred" : "hasExactSynonym",
- "val" : "multiply inhering quality of a physical entity "
}, {
"pred" : "hasExactSynonym",
"val" : "quality of a continuant"
@@ -12539,27 +12366,6 @@
"val" : "quality"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "lbl" : "maximally connected",
- "type" : "CLASS",
- "meta" : {
- "definition" : {
- "val" : "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.",
- "xrefs" : [ "GOC:dos" ]
- },
- "comments" : [ "What counts as maximally connected may be relative to some specification of granularity." ],
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-7073-9172"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
- "val" : "2014-12-12T08:41:11Z"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "quality"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/PATO_0010001",
"lbl" : "disconnected",
@@ -15198,7 +15004,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002000",
- "lbl" : "boundary_of",
+ "lbl" : "2D boundary of",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -15235,7 +15041,7 @@
}
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002002",
- "lbl" : "has_boundary",
+ "lbl" : "has 2D boundary",
"type" : "PROPERTY",
"meta" : {
"definition" : {
@@ -15634,12 +15440,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a neuron and a material anatomical entity that its soma is part of."
},
- "xrefs" : [ {
- "val" : "RO:0002100"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15649,15 +15451,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some (\n and some ?Y)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15668,9 +15464,6 @@
"definition" : {
"val" : "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n"
},
- "xrefs" : [ {
- "val" : "RO:0002101"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15689,9 +15482,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15728,8 +15518,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between an anatomical structure and a neuron that chemically synapses to it.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. "
},
"xrefs" : [ {
"val" : "RO:0002103"
@@ -15746,18 +15535,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that has_part some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -15808,10 +15591,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. "
},
- "comments" : [ "Relation between a neuron and the structure in which its dendrite receives synapses." ],
- "xrefs" : [ {
- "val" : "RO:0002110"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15824,9 +15603,6 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "synapsed in"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))"
@@ -15836,9 +15612,6 @@
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15849,9 +15622,6 @@
"definition" : {
"val" : "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input."
},
- "xrefs" : [ {
- "val" : "RO:0002113"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15861,18 +15631,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15881,13 +15645,9 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that it chemically synapses to.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n "
},
"comments" : [ "N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n\t‘synapse ; GO:0045202’ that has_part some (\n\t ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))" ],
- "xrefs" : [ {
- "val" : "RO:0002120"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15900,18 +15660,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that part_of some ( that some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -15920,13 +15674,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input."
},
- "comments" : [ "expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)" ],
- "xrefs" : [ {
- "val" : "RO:0002130"
- } ],
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
"val" : "http://purl.obolibrary.org/obo/IAO_0000125"
@@ -15939,18 +15688,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that some Y?)"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
} ]
}
}, {
@@ -16019,8 +15762,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.",
- "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
+ "val" : "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R."
},
"xrefs" : [ {
"val" : "RO:0002134"
@@ -16034,18 +15776,12 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
"val" : " some ( that ( some ( that some Y?)))"
- }, {
- "pred" : "http://purl.obolibrary.org/obo/IAO_0000424",
- "val" : "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))"
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0001900",
"val" : "http://purl.obolibrary.org/obo/RO_0001901"
}, {
"pred" : "http://purl.org/spar/cito/citesAsAuthority",
"val" : "http://www.ncbi.nlm.nih.gov/pubmed/22402613"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "fly_anatomy.ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -16670,9 +16406,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "regulates"
@@ -16705,9 +16438,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "negatively_regulates"
@@ -16740,9 +16470,6 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "gene_ontology"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "positively_regulates"
@@ -20408,6 +20135,47 @@
"val" : "https://orcid.org/0000-0003-4639-4431"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "lbl" : "has small molecule regulator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:27:26Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "lbl" : "has small molecule activator",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a process and a continuant, in which the process is activated by the small molecule continuant"
+ },
+ "xrefs" : [ {
+ "val" : "RO:0012001"
+ } ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-04-22T20:28:37Z"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
+ "val" : "external"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
+ "val" : "has_small_molecule_activator"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012003",
"lbl" : "acts on population of",
@@ -20434,6 +20202,41 @@
"val" : "acts_on_population_of"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "lbl" : "is small molecule regulator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:17Z"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "lbl" : "is small molecule activator of",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
+ "val" : "https://orcid.org/0000-0003-1813-6857"
+ }, {
+ "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
+ "val" : "2020-06-24T13:15:26Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_small_molecule_activator_of"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0012008",
"lbl" : "results in fusion of",
@@ -30497,19 +30300,6 @@
"val" : "uberon"
} ]
}
- }, {
- "id" : "http://purl.obolibrary.org/obo/cl#abbreviation",
- "lbl" : "abbreviation",
- "type" : "PROPERTY",
- "meta" : {
- "basicPropertyValues" : [ {
- "pred" : "http://purl.org/dc/elements/1.1/date",
- "val" : "2022-03-29T15:09:49Z"
- }, {
- "pred" : "http://purl.org/dc/terms/contributor",
- "val" : "https://orcid.org/0000-0002-1773-2692"
- } ]
- }
}, {
"id" : "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim",
"lbl" : "blood_and_immune_upper_slim",
@@ -31072,25 +30862,6 @@
"val" : "seeAlso"
} ]
}
- }, {
- "id" : "http://xmlns.com/foaf/0.1/depicted_by",
- "lbl" : "depicted by",
- "type" : "PROPERTY",
- "meta" : {
- "xrefs" : [ {
- "val" : "http://xmlns.com/foaf/0.1/depicted_by"
- } ],
- "basicPropertyValues" : [ {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
- "val" : "uberon"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag",
- "val" : "true"
- }, {
- "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
- "val" : "depicted_by"
- } ]
- }
} ],
"edges" : [ {
"sub" : "http://purl.obolibrary.org/obo/BFO_0000004",
@@ -31112,74 +30883,6 @@
"sub" : "http://purl.obolibrary.org/obo/BFO_0000141",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0030000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0010000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000125"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0000012",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001008",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000012"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0001010",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001008"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "pred" : "http://purl.obolibrary.org/obo/RO_0000053",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001993"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0010004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0001010"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CARO_0030000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000004"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CHEBI_24431",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/BFO_0000040"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000000",
"pred" : "is_a",
@@ -34582,10 +34285,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0048513",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0048856"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0048513",
- "pred" : "http://purl.obolibrary.org/obo/RO_0002296",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0048583",
"pred" : "is_a",
@@ -34910,10 +34609,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0071704",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0008152"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0071704",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004007",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0071840",
"pred" : "is_a",
@@ -35042,10 +34737,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0098657",
"pred" : "http://purl.obolibrary.org/obo/RO_0002339",
"obj" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0098657",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004009",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0098793",
"pred" : "is_a",
@@ -35154,10 +34845,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_0099537",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0099536"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_0110165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_0110165",
"pred" : "is_a",
@@ -35214,10 +34901,6 @@
"sub" : "http://purl.obolibrary.org/obo/GO_1901576",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/GO_0071704"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/GO_1901576",
- "pred" : "http://purl.obolibrary.org/obo/RO_0004008",
- "obj" : "http://purl.obolibrary.org/obo/CHEBI_50860"
}, {
"sub" : "http://purl.obolibrary.org/obo/GO_1902105",
"pred" : "is_a",
@@ -35410,10 +35093,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0000117",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0000125",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0001018"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0000141",
"pred" : "is_a",
@@ -35586,10 +35265,6 @@
"sub" : "http://purl.obolibrary.org/obo/PATO_0002505",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/PATO_0001404"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/PATO_0010000",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/PATO_0000141"
}, {
"sub" : "http://purl.obolibrary.org/obo/PATO_0010001",
"pred" : "is_a",
@@ -35976,10 +35651,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002497",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000071"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000062",
"pred" : "is_a",
@@ -40125,10 +39796,30 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0011002",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002566"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012000"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012003",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0000057"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012004",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002596"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002598"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012005",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0012008",
"pred" : "subPropertyOf",
@@ -40433,36 +40124,20 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0003000",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0003001"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012000",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012004"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0012001",
+ "pred" : "inverseOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0012005"
}, {
"sub" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to",
"pred" : "inverseOf",
"obj" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to"
} ],
"logicalDefinitionAxioms" : [ {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000003",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002266"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0010000"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0000006",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0000125"
- } ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/CARO_0010000",
- "genusIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053",
- "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001993"
- } ]
- }, {
"definedClassId" : "http://purl.obolibrary.org/obo/CL_0000006",
"genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000197", "http://purl.obolibrary.org/obo/CL_0000540" ],
"restrictions" : [ {
@@ -41882,13 +41557,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
"fillerId" : "http://purl.obolibrary.org/obo/CL_0000000"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048513",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296",
- "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0048583",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -42050,13 +41718,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002215",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0099500"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071704",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0072175",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0035148" ],
@@ -42106,19 +41767,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005604"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098657",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002338",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
- "fillerId" : "http://purl.obolibrary.org/obo/GO_0005737"
- }, {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_0098796",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ],
@@ -42218,13 +41866,6 @@
"propertyId" : "http://purl.obolibrary.org/obo/RO_0002339",
"fillerId" : "http://purl.obolibrary.org/obo/GO_0005576"
} ]
- }, {
- "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901576",
- "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ],
- "restrictions" : [ {
- "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008",
- "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50860"
- } ]
}, {
"definedClassId" : "http://purl.obolibrary.org/obo/GO_1902105",
"genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ],
@@ -42882,7 +42523,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002002",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040", "http://purl.obolibrary.org/obo/CARO_0000003" ],
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
diff --git a/subsets/general_cell_types_upper_slim.obo b/subsets/general_cell_types_upper_slim.obo
index 759d7f857..c7b121e24 100644
--- a/subsets/general_cell_types_upper_slim.obo
+++ b/subsets/general_cell_types_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-09-21/subsets/general_cell_types_upper_slim.owl
+data-version: cl/releases/2023-10-19/subsets/general_cell_types_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -7,7 +7,6 @@ subsetdef: BDS_subset ""
subsetdef: blood_and_immune_upper_slim "a subset of general classes related to blood and the immune system, primarily of hematopoietic origin"
subsetdef: cell_quality ""
subsetdef: common_anatomy ""
-subsetdef: core ""
subsetdef: cumbo ""
subsetdef: cyclostome_subset ""
subsetdef: developmental_classification ""
@@ -49,9 +48,7 @@ subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
-subsetdef: plus ""
subsetdef: prokaryote_subset ""
-subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
@@ -62,24 +59,19 @@ subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: ABBREVIATION ""
-synonymtypedef: abbreviation "abbreviation"
synonymtypedef: blast_name ""
synonymtypedef: common_name ""
synonymtypedef: COMPARATIVE_PREFERRED ""
synonymtypedef: DEPRECATED ""
synonymtypedef: DUBIOUS ""
synonymtypedef: equivalent_name ""
-synonymtypedef: FORMULA ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: HOMOLOGY ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens"
synonymtypedef: in_part ""
-synonymtypedef: InChI ""
-synonymtypedef: InChIKey ""
synonymtypedef: INCONSISTENT ""
-synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
@@ -90,13 +82,12 @@ synonymtypedef: PLURAL "plural term"
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
-synonymtypedef: SMILES ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/general_cell_types_upper_slim
-property_value: owl:versionInfo "2023-09-21" xsd:string
+property_value: owl:versionInfo "2023-10-19" xsd:string
[Term]
id: BFO:0000002
@@ -147,106 +138,6 @@ id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
-[Term]
-id: CARO:0000000
-name: anatomical entity
-def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
-comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
-is_a: CARO:0030000 ! biological entity
-
-[Term]
-id: CARO:0000003
-name: connected anatomical structure
-def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." []
-comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
-subset: core
-is_a: CARO:0000006 ! material anatomical entity
-intersection_of: CARO:0000006 ! material anatomical entity
-intersection_of: bearer_of PATO:0002266 ! 3-D shape
-intersection_of: bearer_of PATO:0010000 ! maximally connected
-relationship: bearer_of PATO:0002266 ! 3-D shape
-relationship: bearer_of PATO:0010000 ! maximally connected
-
-[Term]
-id: CARO:0000006
-name: material anatomical entity
-def: "An anatomical entity that has mass." []
-subset: core
-is_a: CARO:0000000 ! anatomical entity
-intersection_of: CARO:0000000 ! anatomical entity
-intersection_of: bearer_of PATO:0000125 ! mass
-relationship: bearer_of PATO:0000125 ! mass
-
-[Term]
-id: CARO:0000012
-name: multicellular organism
-def: "Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell." []
-comment: MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history. \n\nMH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
-is_a: CARO:0010004 ! cellular organism
-
-[Term]
-id: CARO:0001008
-name: gross anatomical part
-def: "Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. " []
-subset: plus
-is_a: CARO:0000006 ! material anatomical entity
-relationship: part_of CARO:0000012 ! multicellular organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "10.7.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0001010
-name: organism
-def: "Material anatomical entity that is a member of an individual species or is a viral or viroid particle." []
-synonym: "organism or virus or viroid" EXACT []
-is_a: BFO:0000040 ! material entity
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "9/18/11" xsd:string
-property_value: IAO:0000117 "Melissa Haendel" xsd:string
-
-[Term]
-id: CARO:0010000
-name: multicellular anatomical structure
-def: "An anatomical structure that has more than one cell as a part." []
-subset: core
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001008 ! gross anatomical part
-intersection_of: CARO:0000003 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! connected anatomical structure
-intersection_of: bearer_of PATO:0001993 {comment="There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS"} ! multicellular
-relationship: bearer_of PATO:0001993 ! multicellular
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "Sun Feb 27 10:53:00 GMT 2011" xsd:string
-property_value: IAO:0000117 "djs93" xsd:string
-
-[Term]
-id: CARO:0010004
-name: cellular organism
-def: "An individual member of a clade of cellular organisms." []
-comment: A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
-is_a: CARO:0000003 ! connected anatomical structure
-is_a: CARO:0001010 ! organism
-property_value: http://purl.obolibrary.org/obo/IAO_creation_date "7.16.2011" xsd:string
-property_value: IAO:0000117 https://orcid.org/0000-0001-9114-8737
-
-[Term]
-id: CARO:0030000
-name: biological entity
-def: "Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them." []
-comment: Important for alignment with Darwin Core class "Organism".
-is_a: BFO:0000004 ! independent continuant
-
-[Term]
-id: CHEBI:24431
-namespace: chebi_ontology
-def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [ANON:ANON]
-is_a: BFO:0000040 ! material entity
-
-[Term]
-id: CHEBI:50860
-namespace: chebi_ontology
-def: "Any molecular entity that contains carbon." [ANON:ANON]
-synonym: "organic compounds" RELATED [ChEBI:]
-synonym: "organic entity" RELATED [ChEBI:]
-synonym: "organic molecular entities" RELATED [ChEBI:]
-
[Term]
id: CL:0000000
name: cell
@@ -311,7 +202,7 @@ subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
-synonym: "HSC" RELATED abbreviation []
+synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:70337
@@ -367,7 +258,7 @@ id: CL:0000040
name: monoblast
def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740]
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.
-synonym: "CFU-M" RELATED abbreviation []
+synonym: "CFU-M" RELATED OMO:0003000 []
synonym: "colony forming unit macrophage" RELATED []
synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
@@ -409,9 +300,9 @@ name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: human_reference_atlas
-synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437]
-synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437]
-synonym: "CMP" RELATED abbreviation [ISBN:0878932437]
+synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
+synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
@@ -429,13 +320,13 @@ name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: human_reference_atlas
-synonym: "CLP" RELATED abbreviation []
+synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
-synonym: "ELP" RELATED abbreviation []
+synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
@@ -508,7 +399,7 @@ is_a: CL:0000000 ! cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
[Term]
id: CL:0000075
@@ -661,6 +552,7 @@ name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: general_cell_types_upper_slim
+subset: human_reference_atlas
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
@@ -668,6 +560,7 @@ xref: CALOHA:TS-0415
xref: FBbt:00005144
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000133
@@ -681,9 +574,9 @@ id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
-synonym: "BMSC" RELATED abbreviation []
+synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
-synonym: "CFU-F" RELATED abbreviation []
+synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
@@ -691,7 +584,7 @@ synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
-synonym: "MSC" RELATED abbreviation [PMID:11378515]
+synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
@@ -722,7 +615,7 @@ name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
-synonym: "APC" RELATED abbreviation []
+synonym: "APC" RELATED OMO:0003000 []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
@@ -767,14 +660,12 @@ is_a: CL:0000147 ! pigment cell
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
-subset: human_reference_atlas
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000152
@@ -820,7 +711,7 @@ xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
relationship: develops_from CL:0000056 ! myoblast
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI
[Term]
id: CL:0000188
@@ -880,7 +771,7 @@ is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI
[Term]
id: CL:0000211
@@ -1229,7 +1120,7 @@ is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
+property_value: http://xmlns.com/foaf/0.1/depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
[Term]
id: CL:0000541
@@ -1274,9 +1165,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
subset: human_reference_atlas
synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de]
-synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "CFU-GM" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
-synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
+synonym: "GMP" RELATED OMO:0003000 [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
@@ -1328,7 +1219,6 @@ id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
-subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
@@ -1339,7 +1229,6 @@ intersection_of: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
intersection_of: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
intersection_of: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
-relationship: present_in_taxon NCBITaxon:9606
relationship: RO:0002104 PR:000001444 ! has plasma membrane part cadherin-5
relationship: RO:0002104 PR:000002112 ! has plasma membrane part vascular endothelial growth factor receptor 2
relationship: RO:0002104 PR:000016043 ! has plasma membrane part T-cell acute lymphocytic leukemia protein 1
@@ -1508,12 +1397,10 @@ relationship: develops_from CL:0000049 ! common myeloid progenitor
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
-subset: human_reference_atlas
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000775
@@ -1550,7 +1437,6 @@ id: CL:0000782
name: myeloid dendritic cell
def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319]
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
-subset: human_reference_atlas
synonym: "CD11c+CD123- DC" EXACT []
synonym: "interdigitating cell" BROAD []
synonym: "mDC" EXACT []
@@ -1563,7 +1449,6 @@ intersection_of: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleuki
intersection_of: develops_from CL:0000763 ! myeloid cell
relationship: CL:4030046 PR:000001865 ! lacks_plasma_membrane_part interleukin-3 receptor class 2 alpha chain
relationship: develops_from CL:0000763 ! myeloid cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0000825
@@ -1972,7 +1857,6 @@ creation_date: 2010-09-15T01:34:57Z
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
-subset: human_reference_atlas
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
@@ -1981,7 +1865,6 @@ intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: part_of UBERON:0002384 ! connective tissue
-relationship: present_in_taxon NCBITaxon:9606
creation_date: 2010-09-15T03:01:54Z
[Term]
@@ -2054,9 +1937,7 @@ creation_date: 2012-06-27T08:27:35Z
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
-subset: human_reference_atlas
is_a: CL:0000187 ! muscle cell
-relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0008001
@@ -2092,10 +1973,12 @@ relationship: part_of UBERON:8600004 ! visceral muscle tissue
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
+subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
+relationship: present_in_taxon NCBITaxon:9606
[Term]
id: CL:0009004
@@ -4581,7 +4464,7 @@ name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
-synonym: "biological condensate" NARROW []
+synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
@@ -4874,9 +4757,7 @@ synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
-intersection_of: GO:0048856 ! anatomical structure development
-intersection_of: results_in_development_of UBERON:0000062 ! organ
-relationship: results_in_development_of UBERON:0000062 ! organ
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI
[Term]
id: GO:0048583
@@ -4947,6 +4828,7 @@ name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
+synonym: "tissue remodelling" EXACT []
is_a: GO:0032501 ! multicellular organismal process
[Term]
@@ -5167,12 +5049,14 @@ id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
+subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
[Term]
id: GO:0051239
@@ -5405,9 +5289,6 @@ synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
-intersection_of: GO:0008152 ! metabolic process
-intersection_of: has_primary_input_or_output CHEBI:50860
-relationship: has_primary_input_or_output CHEBI:50860
created_by: mah
creation_date: 2010-03-08T03:32:18Z
@@ -5587,11 +5468,6 @@ namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport
-intersection_of: GO:0006810 ! transport
-intersection_of: has_primary_input CHEBI:24431
-intersection_of: has_target_end_location GO:0005737 ! cytoplasm
-intersection_of: has_target_start_location GO:0005576 ! extracellular region
-relationship: has_primary_input CHEBI:24431
relationship: has_target_end_location GO:0005737 ! cytoplasm
relationship: has_target_start_location GO:0005576 ! extracellular region
@@ -5730,10 +5606,11 @@ id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
+subset: gocheck_do_not_annotate
subset: goslim_pir
-is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
+property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z
@@ -5808,9 +5685,6 @@ synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
-intersection_of: GO:0009058 ! biosynthetic process
-intersection_of: has_primary_output CHEBI:50860
-relationship: has_primary_output CHEBI:50860
created_by: pr
creation_date: 2012-11-05T11:04:40Z
@@ -6197,8 +6071,6 @@ name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
-def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities." [PATOC:GVG]
-synonym: "trait" EXACT []
is_a: BFO:0000020 ! specifically dependent continuant
[Term]
@@ -6244,17 +6116,6 @@ subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology
-[Term]
-id: PATO:0000125
-name: mass
-namespace: quality
-def: "A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter." [PATOC:GVG]
-comment: For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
-subset: attribute_slim
-subset: relational_slim
-subset: scalar_slim
-is_a: PATO:0001018 ! physical quality
-
[Term]
id: PATO:0000141
name: structure
@@ -6346,7 +6207,6 @@ synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
-synonym: "multiply inhering quality of a physical entity " EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
@@ -6662,16 +6522,6 @@ is_a: PATO:0001404 ! nucleate quality
relationship: dc-contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z
-[Term]
-id: PATO:0010000
-name: maximally connected
-namespace: quality
-def: "A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure." [GOC:dos]
-comment: What counts as maximally connected may be relative to some specification of granularity.
-is_a: PATO:0000141 ! structure
-relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
-creation_date: 2014-12-12T08:41:11Z
-
[Term]
id: PATO:0010001
name: disconnected
@@ -7591,7 +7441,7 @@ intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
[Term]
id: UBERON:0000025
@@ -7692,7 +7542,7 @@ relationship: connects UBERON:0001630 ! muscle organ
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata
relationship: part_of UBERON:0002204 {source="OG"} ! musculoskeletal system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000073", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000003 "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001286", ontology="VHOG", source="DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" xsd:string {external_ontology="FMA"}
@@ -7801,7 +7651,6 @@ xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological_process
@@ -8097,7 +7946,7 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string
[Term]
@@ -8249,7 +8098,7 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: overlaps UBERON:0001004 {notes="exceptions in some taxa"} ! respiratory system
relationship: part_of UBERON:0000033 ! head
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
@@ -8277,7 +8126,7 @@ intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string
[Term]
@@ -8774,7 +8623,7 @@ relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string
@@ -8875,7 +8724,7 @@ intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}
@@ -8950,7 +8799,7 @@ xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string
@@ -8990,8 +8839,8 @@ xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string
@@ -9037,7 +8886,7 @@ is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
relationship: never_in_taxon NCBITaxon:6040
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
@@ -9076,7 +8925,7 @@ is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
@@ -9266,7 +9115,7 @@ relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:string
property_value: http://xmlns.com/foaf/0.1/depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:string
@@ -9352,7 +9201,7 @@ relationship: never_in_taxon NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
relationship: never_in_taxon NCBITaxon:6073
relationship: never_in_taxon NCBITaxon:6157
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: IAO:0000232 "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
@@ -9393,7 +9242,7 @@ xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}
@@ -9451,8 +9300,8 @@ relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: never_in_taxon NCBITaxon:6040
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
@@ -9549,7 +9398,7 @@ is_a: UBERON:0015203 ! non-connected functional system
relationship: capable_of_part_of GO:0007600 ! sensory perception
relationship: overlaps UBERON:0001016 ! nervous system
relationship: part_of UBERON:0004456 ! entire sense organ system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string
@@ -9591,7 +9440,7 @@ is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -9703,7 +9552,7 @@ intersection_of: composed_primarily_of CL:0008002 ! skeletal muscle fiber
relationship: composed_primarily_of CL:0008002 ! skeletal muscle fiber
relationship: develops_from UBERON:0003082 ! myotome
relationship: part_of UBERON:0014892 ! skeletal muscle organ
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/c/c0/Skeletal_muscle.jpg" xsd:anyURI
property_value: editor_note "TODO - add skeletal muscle organ? See GO:0060538 skeletal muscle organ development. Todo - group FBbt:00005073 - somatic muscle." xsd:string
property_value: UBPROP:0000001 "Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005277", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Tissue which consists of skeletal muscle fibers surrounded by endomysium. Examples: Skeletal muscle tissue of biceps, Skeletal muscle tissue of diaphragm[FMA]" xsd:string {external_class="FMA:14069", ontology="FMA"}
@@ -10121,7 +9970,7 @@ relationship: only_in_taxon NCBITaxon:7711 {source="http://tolweb.org/Chordata/2
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: produces PR:000014841 ! sonic hedgehog protein
relationship: ventral_to UBERON:0001049 ! neural tube
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000032", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000135", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000327", ontology="AAO", source="AAO:LAP"}
@@ -10170,7 +10019,7 @@ is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
relationship: never_in_taxon NCBITaxon:7712 {source="PMID:17237766"}
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: editor_note "currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk" xsd:string
property_value: UBPROP:0000001 "Post-cranial axial segments which form sclerotome and dermomyotome.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010569", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000155", ontology="TAO", source="ZFIN:curator"}
@@ -10245,8 +10094,8 @@ relationship: develops_from UBERON:0005062 {source="PMID:11523831"} ! neural fol
relationship: existence_starts_during UBERON:0000110 {source="PMID:11523831"} ! neurula stage
relationship: only_in_taxon NCBITaxon:89593 {notes="Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells", source="ISBN:0073040584"} ! Craniata
relationship: part_of UBERON:0002346 {source="XAO", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neurectoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: editor_note "consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams)." xsd:string
property_value: RO:0002174 NCBITaxon:117565 {source="ISBN:0073040584", source="PMID:17377535"}
property_value: UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000045", ontology="TAO", source="ZFIN:curator"}
@@ -10354,7 +10203,7 @@ intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0000949 ! endocrine system
relationship: capable_of GO:0046879 ! hormone secretion
relationship: part_of UBERON:0000949 ! endocrine system
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/d/da/Illu_endocrine_system.png" xsd:anyURI
[Term]
id: UBERON:0002371
@@ -10399,7 +10248,7 @@ relationship: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0002390 {source="FMA", source="MA"} ! hematopoietic system
relationship: part_of UBERON:0002405 ! immune system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg" xsd:anyURI
property_value: editor_note "consider placement of NCIT:C53466 medullary bone" xsd:string
property_value: editor_note "TODO - create superclass for bone marrow / head kidney. both are portions of tissue in the hematopoetic system. also consider adding as subclass of zone of bone organ for consistency with FMA. See also: Leydig and epigonal organs" xsd:string
property_value: UBPROP:0000003 "The bone marrow is the hematopoietic organ in all vertebrates but fishes, in which hematopoiesis occurs in the kidney.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001218", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood Cells and Blood Cell Development in the Animal Kingdom. Annual Review of Cell and Developmental Biology (2006)", source="http://bgee.unil.ch/"}
@@ -10628,7 +10477,7 @@ is_a: UBERON:0000062 ! organ
relationship: capable_of GO:0046903 ! secretion
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: produces UBERON:0000463 ! organism substance
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001434
property_value: UBPROP:0000007 "glandular" xsd:string
@@ -10654,7 +10503,7 @@ xref: VHOG:0000243
xref: Wikipedia:Epiblast
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part CL:0000352 ! epiblast cell
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
property_value: editor_note "MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class" xsd:string
property_value: UBPROP:0000003 "In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000243", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009)", source="http://bgee.unil.ch/"}
@@ -10761,7 +10610,7 @@ is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0000926 ! mesoderm
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000107", ontology="VHOG", source="http://bgee.unil.ch/"}
[Term]
@@ -10798,7 +10647,7 @@ is_a: UBERON:0016879 ! future central nervous system
relationship: developmentally_induced_by UBERON:0002328 {source="Wikipedia"} ! notochord
relationship: immediate_transformation_of UBERON:0007284 {source="Bgee:AN"} ! presumptive neural plate
relationship: only_in_taxon NCBITaxon:7711 {source="GOTAX:0000352"} ! Chordata
-property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
+property_value: depicted:by "https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png" xsd:anyURI
property_value: UBPROP:0000001 "The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000132", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000068", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
@@ -10832,7 +10681,7 @@ is_a: UBERON:0015212 ! lateral structure
relationship: existence_starts_during UBERON:0000109 ! gastrula stage
relationship: immediate_transformation_of UBERON:0007285 {source="Bgee:AN"} ! presumptive paraxial mesoderm
relationship: in_lateral_side_of UBERON:0000922 ! embryo
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010568", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000114", ontology="VHOG", source="DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here)" xsd:string {external_ontology="ZFA"}
@@ -10870,7 +10719,7 @@ is_a: UBERON:0007524 {source="EHDAA2"} ! dense mesenchyme tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0000926 {source="EHDAA2", source="VHOG"} ! mesoderm
relationship: surrounds UBERON:0003887 ! intraembryonic coelom
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010574", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000118", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
@@ -10911,7 +10760,7 @@ xref: ZFA:0001056
is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure
relationship: contributes_to_morphology_of UBERON:0001630 ! muscle organ
relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: editor_note "The term 'myotome' is also used to describe the muscles served by a single nerve root / spinal segment - consider adding new class, myomere." xsd:string
property_value: UBPROP:0000001 "Portion of the somites giving rise to body wall muscle masses. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001056", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "In all vertebrates, the skeletal muscle of the body axis is chiefly derived from an early embryonic compartment, known as the myotome.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001244", ontology="VHOG", source="DOI:10.1038/sj.embor.embor920 Hollway GE, Currie PD, Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Rep.(2003)", source="http://bgee.unil.ch/"}
@@ -10942,7 +10791,7 @@ is_a: UBERON:0005856 {source="EHDAA2"} ! developing mesenchymal condensation
is_a: UBERON:0007530 {source="EHDAA2"} ! migrating mesenchyme population
relationship: develops_from UBERON:0002329 {source="ZFA"} ! somite
relationship: only_in_taxon NCBITaxon:7742 {source="VHOG:0000680"} ! Vertebrata
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png" xsd:anyURI
property_value: UBPROP:0000001 "Skeletogenic portion of somites.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010571", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000680", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "part_of somite in XAO" xsd:string {external_ontology="XAO"}
@@ -11002,7 +10851,7 @@ intersection_of: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: composed_primarily_of CL:0008019 ! mesenchymal cell
relationship: functionally_related_to GO:0032502 ! developmental process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg" xsd:anyURI
property_value: editor_note "the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense" xsd:string
property_value: UBPROP:0000001 "A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000393", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010427", ontology="AAO", source="AAO:EJS"}
@@ -11578,7 +11427,7 @@ relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0011137 ! axial skeletal system
relationship: present_in_taxon NCBITaxon:9606
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
+property_value: depicted:by "http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg" xsd:anyURI
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
property_value: UBPROP:0000001 "Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000056", ontology="VSAO", source="PSPUB:0000170"}
@@ -12658,7 +12507,6 @@ property_value: IAO:0000118 "derives_into" xsd:string
[Typedef]
id: RO:0002000
name: 2D boundary of
-name: boundary_of
def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" []
property_value: editor_note "A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts." xsd:string
property_value: editor_note "Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape." xsd:string
@@ -12670,7 +12518,7 @@ property_value: IAO:0000118 "is boundary of" xsd:string
property_value: IAO:0000118 "surface of" xsd:string
property_value: RO:0001900 RO:0001901
is_a: RO:0002323 ! mereotopologically related to
-inverse_of: has_boundary ! has_boundary
+inverse_of: has_boundary ! has 2D boundary
[Typedef]
id: RO:0002006
@@ -12774,10 +12622,7 @@ is_a: RO:0002222 ! temporally related to
[Typedef]
id: RO:0002100
name: has soma location
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
-def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
-xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
@@ -12786,15 +12631,11 @@ range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
-expand_expression_to: "BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)" []
[Typedef]
id: RO:0002101
name: fasciculates with
-namespace: fly_anatomy.ontology
-def: "Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y" [https://orcid.org/0000-0002-7073-9172]
def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" []
-xref: RO:0002101
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -12838,10 +12679,7 @@ expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
[Typedef]
id: RO:0002110
name: has postsynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " []
-comment: Relation between a neuron and the structure in which its dendrite receives synapses.
-xref: RO:0002110
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
@@ -12852,15 +12690,12 @@ domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
inverse_of: RO:0002113 ! has presynaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))" []
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 some (\n http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (\n http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))" []
[Typedef]
id: RO:0002113
name: has presynaptic terminal in
-namespace: fly_anatomy.ontology
def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." []
-xref: RO:0002113
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000118 "synapses in" xsd:string
@@ -12868,34 +12703,25 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
id: RO:0002120
name: synapsed to
-namespace: fly_anatomy.ontology
def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " []
-def: "Relation between a neuron and an anatomical structure that it chemically synapses to." [https://orcid.org/0000-0002-7073-9172]
comment: N1 synapsed_to some N2 \nExpands to:\nN1 SubclassOf ( \n has_part some (\n ‘pre-synaptic membrane ; GO:0042734’ that part_of some ( \n ‘synapse ; GO:0045202’ that has_part some (\n ‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
-xref: RO:0002120
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002486 ! sends output to
-expand_expression_to: "BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0042734 that part_of some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some Y?)))" []
[Typedef]
id: RO:0002130
name: has synaptic terminal in
-namespace: fly_anatomy.ontology
def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." []
-def: "A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [https://orcid.org/0000-0002-7073-9172]
-comment: expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
-xref: RO:0002130
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
@@ -12904,7 +12730,6 @@ property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)" []
expand_expression_to: "RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)" []
[Typedef]
@@ -13073,7 +12898,7 @@ property_value: IAO:0000118 "inheres in part of" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: RO:0001900 RO:0001901
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: RO:0000052 part_of {RO:0002582="true"}
is_a: RO:0002502 ! depends on
transitive_over: part_of ! part_of
@@ -13124,7 +12949,7 @@ name: part of structure that is capable of
def: "this relation holds between c and p when c is part of some c', and c' is capable of p." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "false" xsd:boolean
-holds_over_chain: part_of capable_of {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: part_of capable_of {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -13332,7 +13157,7 @@ property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
-holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: RO:0002327 occurs_in {RO:0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -13422,7 +13247,7 @@ subset: ro-eco
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
-holds_over_chain: has_part occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
+holds_over_chain: has_part occurs_in {RO:0002581="true"}
[Typedef]
id: RO:0002481
@@ -13679,6 +13504,33 @@ domain: BFO:0000040 ! material entity
range: BFO:0000040 ! material entity
is_a: RO:0002566 ! causally influences
+[Typedef]
+id: RO:0012000
+name: has small molecule regulator
+def: "a relation between a process and a continuant, in which the process is regulated by the small molecule continuant" []
+is_a: has_participant ! has participant
+inverse_of: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:27:26Z
+
+[Typedef]
+id: RO:0012004
+name: is small molecule regulator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process" []
+is_a: RO:0002596 ! capable of regulating
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:17Z
+
+[Typedef]
+id: RO:0012005
+name: is small molecule activator of
+def: "a relation between a continuant and a process, in which the continuant is a small molecule that activates the process" []
+property_value: seeAlso "https://wiki.geneontology.org/Is_small_molecule_activator_of" xsd:anyURI
+is_a: RO:0002598 ! capable of positively regulating
+is_a: RO:0012004 ! is small molecule regulator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-06-24T13:15:26Z
+
[Typedef]
id: RO:0012011
name: indirectly causally upstream of
@@ -13811,7 +13663,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002220
property_value: editor_note "This relation acts as a join point with BSPO" xsd:string
-property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {http://www.w3.org/2000/01/rdf-schema#seeAlso="issuecomment-218584934"}
+property_value: IAO:0000112 "A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts." xsd:string {seeAlso="issuecomment-218584934"}
property_value: IAO:0000112 "The epidermis layer of a vertebrate is adjacent to the dermis." xsd:string
property_value: IAO:0000112 "The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies." xsd:string
property_value: IAO:0000112 "The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used." xsd:string
@@ -13859,7 +13711,7 @@ xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
domain: UBERON:0000061 ! anatomical structure
range: UBERON:0000061 ! anatomical structure
-holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: attaches_to part_of {RO:0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -13937,7 +13789,7 @@ xref: RO:0002216
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has function in" xsd:string
property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/
-holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: capable_of part_of {RO:0002582="true"}
is_a: functionally_related_to ! functionally related to
is_a: RO:0002500 ! causal agent in process
@@ -14180,13 +14032,6 @@ name: deep to
namespace: uberon
xref: BSPO:0000107
-[Typedef]
-id: depicted_by
-name: depicted by
-namespace: uberon
-xref: http://xmlns.com/foaf/0.1/depicted_by
-is_metadata_tag: true
-
[Typedef]
id: developmentally_induced_by
name: developmentally induced by
@@ -14521,7 +14366,6 @@ property_value: IAO:0000232 "This is a grouping relation that collects relations
[Typedef]
id: has_boundary
name: has 2D boundary
-name: has_boundary
namespace: uberon
def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" []
xref: RO:0002002
@@ -14533,7 +14377,6 @@ property_value: IAO:0000118 "has boundary" xsd:string
property_value: IAO:0000118 "has_2D_boundary" xsd:string
property_value: RO:0001900 RO:0001901
domain: BFO:0000040 ! material entity
-domain: CARO:0000003 ! connected anatomical structure
range: BFO:0000141 ! immaterial entity
is_a: RO:0002323 ! mereotopologically related to
@@ -14659,7 +14502,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
+domain: UBERON:0000061 {IAO:0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -14849,12 +14692,23 @@ property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {IAO:0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
is_asymmetric: true
+[Typedef]
+id: has_small_molecule_activator
+name: has small molecule activator
+namespace: external
+def: "a relation between a process and a continuant, in which the process is activated by the small molecule continuant" []
+xref: RO:0012001
+is_a: RO:0012000 ! has small molecule regulator
+inverse_of: RO:0012005 ! is small molecule activator of
+created_by: https://orcid.org/0000-0003-1813-6857
+creation_date: 2020-04-22T20:28:37Z
+
[Typedef]
id: has_start_location
name: has start location
@@ -15098,17 +14952,14 @@ transitive_over: branching_part_of ! branching part of
[Typedef]
id: innervates
name: innervates
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." []
-def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002134
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
transitive_over: part_of ! part_of
-expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
[Typedef]
@@ -15151,8 +15002,8 @@ property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
-domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
-range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+domain: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
+range: BFO:0000004 {IAO:0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
transitive_over: part_of ! part_of
@@ -15208,7 +15059,6 @@ is_a: regulated_by ! regulated by
id: negatively_regulates
name: negatively regulates
namespace: external
-namespace: gene_ontology
def: "p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -15257,7 +15107,6 @@ is_class_level: true
id: occurs_in
name: occurs in
namespace: external
-namespace: gene_ontology
def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" []
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
@@ -15317,7 +15166,7 @@ xref: RO:0002131
property_value: IAO:0000114 IAO:0000125
property_value: RO:0001900 RO:0001901
holds_over_chain: has_part overlaps
-holds_over_chain: has_part part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
+holds_over_chain: has_part part_of {RO:0002582="true"}
holds_over_chain: part_of part_of
is_symmetric: true
is_a: RO:0002323 ! mereotopologically related to
@@ -15391,7 +15240,6 @@ is_a: regulated_by ! regulated by
id: positively_regulates
name: positively regulates
namespace: external
-namespace: gene_ontology
def: "p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -15577,7 +15425,6 @@ is_a: causally_downstream_of_or_within ! causally downstream of or within
id: regulates
name: regulates
namespace: external
-namespace: gene_ontology
def: "p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q." []
subset: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
@@ -15967,10 +15814,8 @@ is_a: adjacent_to ! adjacent to
[Typedef]
id: synapsed_by
name: synapsed by
-namespace: fly_anatomy.ontology
namespace: uberon
def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " []
-def: "Relation between an anatomical structure and a neuron that chemically synapses to it." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002103
property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613
property_value: IAO:0000114 IAO:0000125
@@ -15979,7 +15824,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
is_a: RO:0002485 ! receives input from
inverse_of: RO:0002120 ! synapsed to
-expand_expression_to: "BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))" []
expand_expression_to: "BFO_0000051 some (GO_0045211 that part_of some (GO_0045202 that has_part some (GO_0042734 that BFO_0000050 some Y?)))" []
[Typedef]
diff --git a/subsets/general_cell_types_upper_slim.owl b/subsets/general_cell_types_upper_slim.owl
index 5424f8b71..cf6adf3d8 100644
--- a/subsets/general_cell_types_upper_slim.owl
+++ b/subsets/general_cell_types_upper_slim.owl
@@ -10,10 +10,8 @@
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
- xmlns:caro="http://purl.obolibrary.org/obo/caro#"
xmlns:cito="http://purl.org/spar/cito/"
xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
- xmlns:fbbt="http://purl.obolibrary.org/obo/fbbt#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:obo2="http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/"
xmlns:pato="http://purl.obolibrary.org/obo/pato#"
@@ -31,8 +29,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-09-21
+
+ 2023-10-19
@@ -99,7 +97,7 @@ We don't have definitions of 'meaning' or 'expression'
Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
-We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition
@@ -273,18 +271,6 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
-
-
-
-
-
-
-
-
-
-
-
-
@@ -315,6 +301,19 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (
+
+
+
+ CHEBI:26523 (reactive oxygen species) has an exact synonym (ROS), which is of type OMO:0003000 (abbreviation)
+ A synonym type for describing abbreviations or initalisms
+
+
+ 2023-03-03
+ abbreviation
+
+
+
+
@@ -675,22 +674,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -699,17 +682,6 @@ WHERE {
-
-
-
- 2022-03-29T15:09:49Z
-
- abbreviation
-
-
-
-
-
@@ -749,46 +721,6 @@ WHERE {
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1043,14 +975,6 @@ WHERE {
-
-
-
-
-
-
-
-
@@ -1547,12 +1471,6 @@ WHERE {
-
-
-
-
-
-
@@ -2016,14 +1934,7 @@ WHERE {
-
- http://xmlns.com/foaf/0.1/depicted_by
- uberon
- depicted_by
- true
- depicted_by
- depicted by
-
+
@@ -2222,7 +2133,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
unfolds_in
BFO:0000066
external
- gene_ontology
occurs_in
@@ -2917,7 +2827,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
surface of
2D boundary of
- boundary_of
@@ -2927,7 +2836,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
-
my body has 2D boundary the surface of my skin
a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
@@ -2943,7 +2851,6 @@ A continuant cannot have an occurrent as part: use 'participates in'.
has_boundary
has 2D boundary
has 2D boundary
- has_boundary
@@ -3280,23 +3187,12 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and a material anatomical entity that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
- BFO_0000051 some (GO_0043025 and BFO_0000050 some ?Y)
- RO:0002100
- fly_anatomy.ontology
- has_soma_location
has soma location
-
-
-
- Relation between a neuron and an anatomical structure that its soma is part of.
-
-
@@ -3307,7 +3203,6 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3334,17 +3229,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
))))))
- RO:0002101
- fly_anatomy.ontology
- fasciculates_with
fasciculates with
-
-
-
- Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
-
-
@@ -3390,27 +3276,18 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.
- Relation between an anatomical structure and a neuron that chemically synapses to it.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that has_part some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0045211 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0042734 that BFO_0000050 some ?Y)))
RO:0002103
- fly_anatomy.ontology
uberon
synapsed_by
synapsed_by
synapsed by
synapsed by
-
-
-
- Relation between an anatomical structure and a neuron that chemically synapses to it.
-
-
@@ -3449,16 +3326,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
synapsed in
- BFO_0000051 some (GO_0045211 and BFO_0000050 some (GO_0045202 and BFO_0000050 some ?Y))
http://purl.obolibrary.org/obo/BFO_0000051 some (
http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some (
http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y))
- RO:0002110
- fly_anatomy.ontology
- has_postsynaptic_terminals_in
- Relation between a neuron and the structure in which its dendrite receives synapses.
has postsynaptic terminal in
@@ -3477,12 +3349,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
synapses in
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000050 some ?Y))
- RO:0002113
- fly_anatomy.ontology
- has_presynaptic_terminals_in
has presynaptic terminal in
@@ -3506,16 +3374,11 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
- Relation between a neuron and an anatomical structure that it chemically synapses to.
<http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that part_of some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0045211> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- BFO_0000051 some (GO_0042734 that BFO_0000050 some (GO_0045202 that BFO_0000051 some (GO_0045211 that BFO_0000050 some ?Y)))
- RO:0002120
- fly_anatomy.ontology
- synapsed_to
N1 synapsed_to some N2
Expands to:
N1 SubclassOf (
@@ -3525,12 +3388,6 @@ N1 SubclassOf (
‘post-synaptic membrane ; GO:0045211’ that part_of some N2))))
synapsed to
-
-
-
- Relation between a neuron and an anatomical structure that it chemically synapses to.
-
-
@@ -3545,25 +3402,13 @@ N1 SubclassOf (
A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
has synapse in
<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
- RO_0002131 some (GO_0045202 and BFO_0000050 some ?Y)
- RO:0002130
- fly_anatomy.ontology
- has_synaptic_terminals_in
- expands to - X overlaps some ('synapse ; GO_0045202' that part_of some ?Y)
has synaptic terminal in
-
-
-
- A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
-
-
@@ -3675,26 +3520,17 @@ N1 SubclassOf (
Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
<http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
- RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))
RO:0002134
- fly_anatomy.ontology
uberon
innervates
innervates
innervates
innervates
-
-
-
- Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
@@ -4174,7 +4010,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.false
RO:0002211
external
- gene_ontology
regulates
@@ -4203,7 +4038,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002212
external
- gene_ontology
negatively_regulates
@@ -4237,7 +4071,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
RO:0002213
external
- gene_ontology
positively_regulates
@@ -7248,6 +7081,37 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is regulated by the small molecule continuant
+
+ 2020-04-22T20:27:26Z
+ has small molecule regulator
+
+
+
+
+
+
+
+
+
+ a relation between a process and a continuant, in which the process is activated by the small molecule continuant
+
+ 2020-04-22T20:28:37Z
+ RO:0012001
+ external
+ has_small_molecule_activator
+ has_small_molecule_activator
+ has small molecule activator
+ has small molecule activator
+
+
+
+
@@ -7268,6 +7132,32 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process
+
+ 2020-06-24T13:15:17Z
+ is small molecule regulator of
+
+
+
+
+
+
+
+
+
+ a relation between a continuant and a process, in which the continuant is a small molecule that activates the process
+
+ 2020-06-24T13:15:26Z
+ is small molecule activator of
+ https://wiki.geneontology.org/Is_small_molecule_activator_of
+
+
+
+
@@ -8026,256 +7916,6 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CARO:0000000
- Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach). The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
- anatomical entity
-
-
-
-
- A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
- CAROC:Brownsville2014
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
- CARO:0000003
-
- Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
- connected anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical entity that has mass.
- CARO:0000006
-
- material anatomical entity
-
-
-
-
-
-
-
-
- Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell.
- CARO:0000012
- MH: Can't define this class based on 2 or more cells because most multi cellular organisms (if not all) have only a single cell at some point in life history.
-
-MH: sexual subtypes should probably be logically defined based on sexual processes or sex qualities.
- multicellular organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
-
- 10.7.2011
-
- gross anatomical part
-
-
-
-
-
-
-
-
- Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
- Melissa Haendel
- 9/18/11
- organism or virus or viroid
- organism
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- An anatomical structure that has more than one cell as a part.
- djs93
- Sun Feb 27 10:53:00 GMT 2011
- CARO:0010000
-
- multicellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
-
-
-
-
-
-
-
-
-
- An individual member of a clade of cellular organisms.
-
- 7.16.2011
- CARO:0010004
- A general term for organism that is agnostic about single cell vs multi-cellular. Note that this is a subclass of 'anatomical structure', meaning that an organism must be a connected structure. For example, if I take one plant and make a rooted cutting from a it, I now have two (clonally related) organisms.
- cellular organism
-
-
-
-
-
-
-
-
- Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them.
- Important for alignment with Darwin Core class "Organism".
- biological entity
-
-
-
-
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- chebi_ontology
- CHEBI:24431
-
-
-
-
- A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
- ANON:ANON
-
-
-
-
-
-
-
- Any molecular entity that contains carbon.
- chebi_ontology
- organic compounds
- organic entity
- organic molecular entities
- CHEBI:50860
-
-
-
-
- Any molecular entity that contains carbon.
- ANON:ANON
-
-
-
-
- organic compounds
- ChEBI:
-
-
-
-
- organic entity
- ChEBI:
-
-
-
-
- organic molecular entities
- ChEBI:
-
-
-
-
@@ -8582,7 +8222,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
HSC
-
+
@@ -8705,7 +8345,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-M
-
+
@@ -8792,21 +8432,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CFU-GEMM
ISBN:0878932437
-
+
CFU-S
ISBN:0878932437
-
+
CMP
ISBN:0878932437
-
+
@@ -8892,13 +8532,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CLP
-
+
ELP
-
+
@@ -9022,7 +8662,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
epithelial cell
- https://www.swissbiopics.org/api/image/Epithelial_cells.svg
+ https://www.swissbiopics.org/api/image/Epithelial_cells.svg
@@ -9506,6 +9146,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
+
BTO:0002606
CALOHA:TS-0415
FBbt:00005144
@@ -9513,6 +9154,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neuroglial cell
neuroglia
+
Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
glial cell
@@ -9598,20 +9240,20 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BMSC
-
+
CFU-F
-
+
MSC
PMID:11378515
-
+
@@ -9705,7 +9347,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
APC
-
+
@@ -9813,10 +9455,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell that specializes in controlled release of one or more substances.
-
BTO:0003659
FMA:86916
-
secretory cell
@@ -9965,7 +9605,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
muscle fiber
myocyte
muscle cell
- https://www.swissbiopics.org/api/image/Muscle_cells.svg
+ https://www.swissbiopics.org/api/image/Muscle_cells.svg
@@ -10128,7 +9768,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CALOHA:TS-0868
FMA:86740
photoreceptor cell
- https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
+ https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg
@@ -11110,7 +10750,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
neuron
- https://www.swissbiopics.org/api/image/Neuron_cells.svg
+ https://www.swissbiopics.org/api/image/Neuron_cells.svg
@@ -11372,7 +11012,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -11381,7 +11021,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ISBN:0721601464
PMCID:PMC2213186
PMCID:PMC548021
-
+
@@ -11503,10 +11143,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A mesenchymal stem cell capable of developing into blood vessel endothelium.
-
angioblast
chondroplast
-
These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
angioblastic mesenchymal cell
@@ -12039,8 +11677,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the monocyte, granulocyte, or mast cell lineage.
-
-
myeloid leukocyte
@@ -12162,13 +11798,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dendritic cell of the myeloid lineage.
-
interdigitating cell
veiled cell
BTO:0004721
CD11c+CD123- DC
mDC
-
These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).
myeloid dendritic cell
@@ -12277,18 +11911,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Most markers only described for human pro NK cells.
pro-NK cell
-
-
-
- null cell
- PMID:11532393
-
-
-
-
- preNK cell
- PMID:11532393
-
@@ -12315,6 +11937,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PMID:15032583
PMID:15766674
+
+
+
+ null cell
+ PMID:11532393
+
+
+
+
+ preNK cell
+ PMID:11532393
+
@@ -13581,13 +13215,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
-
2010-09-15T03:01:54Z
CALOHA:TS-2096
FMA:63875
MESH:D003239
-
connective tissue cell
@@ -13774,8 +13406,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Any muscle cell in which the fibers are not organised into sarcomeres.
-
-
non-striated muscle cell
@@ -13902,7 +13532,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
+
mesenchyme cell
+
mesenchymal cell
@@ -15741,32 +15373,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -20292,8 +19924,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/geneontology/go-ontology/issues/21881
NIF_Subcellular:sao1456184038
non-membrane-enclosed organelle
- biological condensate
cellular_component
+ biological condensate
GO:0043228
non-membrane-bounded organelle
@@ -21113,25 +20745,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
+ https://github.com/geneontology/go-ontology/issues/25943
Wikipedia:Organogenesis
development of an organ
organogenesis
@@ -21365,6 +20981,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
+ tissue remodelling
biological_process
GO:0048771
@@ -21945,9 +21562,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
+ https://github.com/geneontology/go-ontology/issues/24200
establishment of localisation
biological_process
GO:0051234
+
@@ -22592,24 +22211,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
mah
2010-03-08T03:32:18Z
@@ -23112,25 +22714,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -23144,12 +22727,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
uptake
biological_process
@@ -23592,14 +23169,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
+ https://github.com/geneontology/go-ontology/issues/24200
kmv
2019-08-12T18:01:37Z
cellular_component
GO:0110165
+
cellular anatomical entity
@@ -23778,25 +23356,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.
pr
2012-11-05T11:04:40Z
@@ -24815,9 +24376,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
PATO:0000072
- trait
quality
PATO:0000001
quality
@@ -24828,12 +24387,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
PATOC:GVG
-
-
-
- A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities.
- PATOC:GVG
-
@@ -24929,28 +24482,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- quality
- PATO:0000125
-
-
-
- For any biological use of PATO, the concept that should be used is 'mass' and not 'weight'. For example, increased weight of an organism.
- mass
-
-
-
-
- A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
- PATOC:GVG
-
-
-
-
@@ -25121,7 +24652,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
snap:Quality
monadic quality of a continuant
multiply inhering quality of a physical entity
- multiply inhering quality of a physical entity
quality of a continuant
quality of a single physical entity
quality of an object
@@ -25813,27 +25343,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
-
- 2014-12-12T08:41:11Z
- quality
- PATO:0010000
- What counts as maximally connected may be relative to some specification of granularity.
- maximally connected
-
-
-
-
- A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure.
- GOC:dos
-
-
-
-
@@ -28427,8 +27936,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -28479,11 +27988,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
tendon
http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg
-
+
-
+
@@ -28496,13 +28005,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
OG
-
+
AEO
@@ -28753,7 +28262,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -29493,7 +29001,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -29529,14 +29037,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
gastrula stage
-
+
-
+
BILS
@@ -29757,7 +29265,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -29830,7 +29338,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -29843,7 +29351,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -30152,7 +29660,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -30194,14 +29702,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -31433,7 +30941,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -31471,14 +30979,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -31531,7 +31039,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -31568,14 +31076,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -31620,7 +31128,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -31665,7 +31173,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -31678,7 +31186,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -31984,8 +31492,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -32021,24 +31529,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
eye
-
+
-
+
-
+
PMID:21062451
-
+
PMID:21062451
@@ -32650,7 +32158,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -32705,14 +32213,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -32800,7 +32308,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -32847,7 +32355,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
-
+
@@ -32861,7 +32369,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -33728,7 +33236,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Skeletal element that is composed of bone tissue.
@@ -33778,14 +33286,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -33896,7 +33404,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -33936,14 +33444,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -34534,7 +34042,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -34570,14 +34078,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
-
+
-
+
check ctenophore
@@ -34640,9 +34148,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
@@ -34697,15 +34205,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -34724,19 +34232,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -34821,8 +34329,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -34868,11 +34376,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -34885,13 +34393,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
GOTAX:0000352
-
+
ZFA
@@ -35068,12 +34576,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -35113,66 +34621,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -35527,7 +35035,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -35585,14 +35093,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
-
+
-
+
FMA
MA
@@ -35863,14 +35371,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
@@ -35914,24 +35422,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -36397,7 +35905,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -36422,14 +35930,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -36659,9 +36167,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -36693,34 +36201,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -36785,7 +36293,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -36814,7 +36322,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -36827,7 +36335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -36899,7 +36407,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -36943,7 +36451,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -36956,7 +36464,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
VHOG
@@ -37040,7 +36548,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -37083,7 +36591,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
myotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
@@ -37096,7 +36604,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2-abduced
@@ -37152,8 +36660,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -37180,11 +36688,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -37203,13 +36711,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
VHOG:0000680
-
+
ZFA
@@ -37418,7 +36926,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -37434,14 +36942,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -37769,7 +37277,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The bilaminar epithelium formed from the myotome and dermatome.
Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768].
Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]
@@ -37792,7 +37300,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004290
dermomyotome
-
+
@@ -37811,7 +37319,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
ZFA
@@ -38137,7 +37645,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
@@ -38151,7 +37659,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
-
+
@@ -38164,7 +37672,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
2012-08-14
VSAO:0000015
VSAO
@@ -38203,7 +37711,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -38219,14 +37727,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal element
-
+
-
+
VSAO
@@ -38271,7 +37779,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -38310,14 +37818,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -38784,7 +38292,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -38800,14 +38308,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -39104,7 +38612,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -39114,7 +38622,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -39133,7 +38641,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO-modified-relation
@@ -39238,7 +38746,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -39253,7 +38761,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochordal plate
-
+
@@ -39266,7 +38774,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
@@ -39303,7 +38811,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -39320,14 +38828,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -39785,7 +39293,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -39800,14 +39308,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -39897,7 +39405,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39914,14 +39422,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -40020,7 +39528,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40046,7 +39554,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive paraxial mesoderm
-
+
@@ -40062,7 +39570,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -40111,7 +39619,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -40119,7 +39627,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -40132,7 +39640,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -40442,7 +39950,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40459,14 +39967,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -40488,7 +39996,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -40496,14 +40004,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -40663,8 +40171,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -40677,11 +40185,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
subdivision of skeleton
-
+
-
+
@@ -40694,13 +40202,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
UBERONREF:0000003
-
+
VSAO
@@ -41071,7 +40579,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41096,7 +40604,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0011899
epimysium
-
+
@@ -41109,7 +40617,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
FMA
@@ -41215,7 +40723,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41237,7 +40745,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0012429
hematopoietic tissue
-
+
@@ -41250,7 +40758,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
defitional
@@ -41818,7 +41326,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41841,7 +41349,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0016887
entire extraembryonic component
-
+
@@ -41854,7 +41362,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -41940,7 +41448,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41956,14 +41464,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal musculature
-
+
-
+
MA
@@ -42462,27 +41970,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
///////////////////////////////////////////////////////////////////////////////////////
-->
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
@@ -42525,27 +42012,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Should belong in BFO, but lives in caro for now.
-
-
-
-
-
@@ -42566,16 +42032,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
-
-
@@ -43426,5 +42882,5 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
diff --git a/subsets/general_cell_types_upper_slim.tsv b/subsets/general_cell_types_upper_slim.tsv
index db206d0fb..482d60ba7 100644
--- a/subsets/general_cell_types_upper_slim.tsv
+++ b/subsets/general_cell_types_upper_slim.tsv
@@ -1,288 +1,279 @@
?x ?label
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1002
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1018
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1026
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1075
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1082
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1089
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1099
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1106
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1112
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1153
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1168
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1174
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid118
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1185
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1192
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1199
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1205
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid121
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1212
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1219
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1225
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1231
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1238
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1248
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1261
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1273
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1281
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1287
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1293
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1299
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1305
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1311
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1317
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1323
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1339
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1346
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1353
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1361
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1368
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1384
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1395
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1404
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1410
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1423
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1432
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1440
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1446
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1454
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1460
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1468
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1474
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1480
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1530
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1544
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1555
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1568
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1578
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1584
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1590
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1596
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1624
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1635
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1652
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1660
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1669
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1676
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1689
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1700
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1707
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1715
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1721
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1729
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1736
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1744
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1753
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1759
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1766
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1777
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1783
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1790
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1796
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1805
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1811
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1818
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1826
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1833
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1861
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1870
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1877
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1887
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1910
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1920
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1927
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1933
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1938
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1943
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1963
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1973
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1980
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1986
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid1993
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2002
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2008
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2014
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2021
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2029
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2035
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2047
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2054
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2063
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2072
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2078
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2084
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2090
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2096
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2102
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2108
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2117
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2124
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2135
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2141
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2150
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2160
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2166
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2172
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2178
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2186
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2196
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2204
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2210
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2224
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2231
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2237
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2243
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2249
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2255
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2268
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2274
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2292
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2298
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2304
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2314
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2320
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2330
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2336
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2344
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2354
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2360
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2366
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2372
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2381
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2391
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2399
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2405
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2415
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2479
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2513
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2519
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2679
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2686
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2699
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2710
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2726
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2825
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2861
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2888
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2897
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2955
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2974
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2978
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid2998
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3085
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3101
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3180
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3209
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3223
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3242
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3274
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3285
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3293
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid33
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid330
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid338
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3409
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3419
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3430
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid344
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3457
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3515
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid357
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3610
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3629
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid363
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3634
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3648
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3655
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3691
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid370
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3722
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3745
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3777
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3788
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3795
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3807
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3851
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3861
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3870
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3881
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3894
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3903
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3913
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3928
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3937
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3948
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3965
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid3987
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4013
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4024
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4052
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4064
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4091
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4122
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4139
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4145
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4157
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4165
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid418
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4182
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid42
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4203
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4218
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4222
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4226
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4230
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4234
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid4238
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid438
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid455
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid472
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid479
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid487
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid519
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid551
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid570
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid578
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid587
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid59
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid593
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid599
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid602
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid609
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid617
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid627
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid635
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid643
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid655
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid661
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid667
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid673
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid685
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid692
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid701
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid707
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid713
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid721
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid757
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid765
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid772
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid785
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid800
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid831
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid844
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid858
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid874
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid894
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid901
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid907
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid916
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid928
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid943
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid950
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid956
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid966
-_:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1043
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1050
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1057
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1067
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1074
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1080
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid112
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1121
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1136
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1142
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid115
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1153
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1160
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1167
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1173
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1180
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1187
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1193
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1199
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1206
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1216
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1229
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1241
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1249
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1255
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1261
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1267
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1273
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1279
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1285
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1291
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1307
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1314
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1321
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1329
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1336
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1352
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1363
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1372
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1378
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1391
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1400
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1408
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1414
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1422
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1428
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1436
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1442
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1448
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1498
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1512
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1523
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1536
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1546
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1552
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1558
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1564
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1592
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1603
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1620
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1628
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1637
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1644
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1657
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1668
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1675
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1683
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1689
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1697
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1704
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1712
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1721
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1727
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1734
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1745
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1751
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1758
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1764
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1773
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1779
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1786
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1794
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1801
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1829
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1838
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1845
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1855
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1878
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1888
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1895
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1901
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1906
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1911
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1931
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1941
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1948
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1954
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1961
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1970
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1976
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1982
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1989
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid1998
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2010
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2017
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2026
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2035
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2041
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2047
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2053
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2059
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2065
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2071
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2080
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2087
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2098
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2104
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2113
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2123
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2129
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2135
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2141
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2149
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2159
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2167
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2182
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2189
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2195
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2201
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2207
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2213
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2226
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2241
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2247
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2253
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2263
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2269
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2279
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2285
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2293
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2303
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2309
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2315
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2321
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2335
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2343
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2349
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2359
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2421
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2455
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2461
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2620
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2627
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2640
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2651
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2667
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2766
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2802
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2829
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2838
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2896
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2915
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2919
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid2939
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3026
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3042
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid31
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3121
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3150
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3164
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3183
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3215
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3226
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3234
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid325
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid331
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3350
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3360
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3371
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid338
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3398
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3456
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3551
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3570
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3575
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3589
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3596
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3632
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3663
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3686
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3718
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3729
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3736
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3748
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3792
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3802
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3811
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3822
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3835
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3844
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3854
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid386
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3869
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3878
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3889
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid39
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3906
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3928
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3954
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3965
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid3993
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4005
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4032
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid406
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4063
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4080
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4086
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4098
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4106
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4123
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4144
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4159
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4163
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4167
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid4171
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid423
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid440
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid447
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid455
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid487
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid519
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid538
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid54
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid546
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid555
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid561
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid567
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid570
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid577
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid585
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid595
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid603
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid611
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid623
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid629
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid635
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid641
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid653
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid660
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid669
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid675
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid681
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid689
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid725
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid733
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid740
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid753
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid768
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid799
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid812
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid826
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid842
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid862
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid869
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid875
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid884
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid896
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid911
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid918
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid924
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid934
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid944
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid970
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid986
+_:Bf4201879X2Ddf98X2D49eeX2D943fX2Da5328987f6d6genid994
"continuant"
"occurrent"
"independent continuant"
@@ -290,17 +281,6 @@ _:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
"specifically dependent continuant"
"material entity"
"immaterial entity"
- "anatomical entity"
- "connected anatomical structure"
- "material anatomical entity"
- "multicellular organism"
- "gross anatomical part"
- "organism"
- "multicellular anatomical structure"
- "cellular organism"
- "biological entity"
-
-
"cell"
"neuronal receptor cell"
"early embryonic cell (metazoa)"
@@ -754,7 +734,6 @@ _:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
"qualitative"
"deviation (from_normal)"
"size"
- "mass"
"structure"
"circular"
"normal"
@@ -792,7 +771,6 @@ _:B3fb7e78fX2D9a5fX2D4acdX2Dacf0X2D5a6543efe0d4genid976
"superelliptic"
"transversely striated"
"nucleated"
- "maximally connected"
"disconnected"
"polymeric"
"anatomical structure quality"