diff --git a/man-roxygen/uif.R b/man-roxygen/uif.R index ceed73cd2..ce127ffbf 100644 --- a/man-roxygen/uif.R +++ b/man-roxygen/uif.R @@ -380,8 +380,7 @@ ##' ## done ##' ## ... ##' ## done -##' The model-based sensitivities have been calculated. -##' It will be cached for future runs. +##' The model-based sensitivities have been calculated ##' Calculating Table Variables... ##' done ##' } @@ -403,53 +402,40 @@ ##' ##' \preformatted{ ##' > fit.s -##' nlmixr SAEM fit (ODE) -##' -##' OBJF AIC BIC Log-likelihood -##' 62335.96 62349.96 62397.88 -31167.98 -##' -##' Time (sec; $time): -##' saem setup FOCEi Evaulate covariance table -##' elapsed 379.32 2.9 1.71 0 19.11 -##' -##' Parameters ($par.fixed): -##' Parameter Estimate SE CV Untransformed (95%CI) -##' lCl log Cl (L/hr) 1.39 0.0240 1.7% 4.01 (3.82, 4.20) -##' lVc log Vc (L) 4.20 0.0256 0.6% 67.0 (63.7, 70.4) -##' lKA log Ka (1/hr) 0.00890 0.0307 344.9% 1.01 (0.950, 1.07) -##' prop.err 0.198 19.8% -##' -##' Omega ($omgea): -##' eta.Cl eta.Vc eta.KA -##' eta.Cl 0.06833621 0.00000000 0.000000 -##' eta.Vc 0.00000000 0.07783316 0.000000 -##' eta.KA 0.00000000 0.00000000 0.111673 -##' -##' Fit Data (object is a modified data.frame): -##' ID TIME DV IPRED PRED IRES RES IWRES -##' 1: 1 0.25 204.8 194.859810 198.21076 9.94018953 6.589244 0.25766777 -##' 2: 1 0.50 310.6 338.006073 349.28827 -27.40607290 -38.688274 -0.40955290 -##' 3: 1 0.75 389.2 442.467750 463.78410 -53.26775045 -74.584098 -0.60809361 -##' --- -##' 6945: 120 264.00 11.3 13.840800 70.58248 -2.54080024 -59.282475 -0.92725039 -##' 6946: 120 276.00 3.9 4.444197 34.41018 -0.54419655 -30.510177 -0.61851500 -##' 6947: 120 288.00 1.4 1.427006 16.77557 -0.02700637 -15.375569 -0.09559342 -##' WRES CWRES CPRED CRES eta.Cl eta.Vc -##' 1: 0.07395107 0.07349997 198.41341 6.38659 0.09153143 0.1366395 -##' 2: -0.26081216 -0.27717947 349.82730 -39.22730 0.09153143 0.1366395 -##' 3: -0.39860485 -0.42988445 464.55651 -75.35651 0.09153143 0.1366395 -##' --- -##' 6945: -0.77916115 -1.34050999 41.10189 -29.80189 0.32007359 -0.1381479 -##' 6946: -0.65906613 -1.28359979 15.51100 -11.61100 0.32007359 -0.1381479 -##' 6947: -0.56746681 -1.22839732 5.72332 -4.32332 0.32007359 -0.1381479 -##' eta.KA -##' 1: 0.1369685 -##' 2: 0.1369685 -##' 3: 0.1369685 -##' --- -##' 6945: -0.2381078 -##' 6946: -0.2381078 -##' 6947: -0.2381078 +##' -- nlmixr SAEM fit (ODE); OBJF calculated from FOCEi approximation ------------- +##' OBJF AIC BIC Log-likelihood Condition Number +##' 62337.09 62351.09 62399.01 -31168.55 82.6086 +##' +##' -- Time (sec; fit.s$time): ----------------------------------------------------- +##' saem setup Likelihood Calculation covariance table +##' elapsed 430.25 31.64 1.19 0 3.44 +##' +##' -- Parameters (fit.s$par.fixed): ----------------------------------------------- +##' Parameter Estimate SE %RSE Back-transformed(95%CI) BSV(CV%) +##' lCl log Cl (L/hr) 1.39 0.0240 1.73 4.01 (3.83, 4.20) 26.6% +##' lVc log Vc (L) 4.20 0.0256 0.608 67.0 (63.7, 70.4) 28.5% +##' lKA log Ka (1/hr) 0.00924 0.0323 349. 1.01 (0.947, 1.08) 34.3% +##' prop.err prop.err 0.198 19.8% +##' Shrink(SD)% +##' lCl 0.248% +##' lVc 1.09% +##' lKA 4.19% +##' prop.err 1.81% +##' +##' No correlations in between subject variability (BSV) matrix +##' Full BSV covariance (fit.s$omega) or correlation (fit.s$omega.R; diagonals=SDs) +##' Distribution stats (mean/skewness/kurtosis/p-value) available in fit.s$shrink +##' +##' -- Fit Data (object fit.s is a modified data.frame): --------------------------- +##' # A tibble: 6,947 x 22 +##' ID TIME DV PRED RES WRES IPRED IRES IWRES CPRED CRES +##' * +##' 1 1 0.25 205. 198. 6.60 0.0741 189. 16.2 0.434 198. 6.78 +##' 2 1 0.5 311. 349. -38.7 -0.261 330. -19.0 -0.291 349. -38.3 +##' 3 1 0.75 389. 464. -74.5 -0.398 434. -45.2 -0.526 463. -73.9 +##' # ... with 6,944 more rows, and 11 more variables: CWRES , eta.Cl , +##' # eta.Vc , eta.KA , depot , centr , Cl , Vc , +# KA , kel , cp ##' ##' } ##' ##'