diff --git a/tox.ini b/tox.ini
index 36d3ed36a..4fe21df47 100644
--- a/tox.ini
+++ b/tox.ini
@@ -49,9 +49,7 @@ envlist =
     firestore-datastore_firestore-{py37,py38,py39,py310,py311,py312,py313},
     grpc-framework_grpc-{py38,py39,py310,py311,py312,py313}-grpclatest,
     kafka-messagebroker_confluentkafka-py39-confluentkafka{0108,0107,0106},
-    kafka-messagebroker_confluentkafka-{py37,py38,py39,py310,py311,py312}-confluentkafkalatest,
-    ;; Package not ready for Python 3.13 (missing wheel)
-    ; kafka-messagebroker_confluentkafka-py313-confluentkafkalatest,
+    kafka-messagebroker_confluentkafka-{py37,py38,py39,py310,py311,py312,py313}-confluentkafkalatest,
     kafka-messagebroker_kafkapython-py38-kafkapython{020001,020000},
     kafka-messagebroker_kafkapython-{py37,py38,pypy310}-kafkapythonlatest,
     kafka-messagebroker_kafkapython-{py38,py39,py310,py311,py312,py313,pypy310}-kafkapythonnglatest,
@@ -66,24 +64,18 @@ envlist =
     mysql-datastore_mysql-mysqllatest-{py37,py38,py39,py310,py311,py312,py313},
     mysql-datastore_pymysql-{py37,py38,py39,py310,py311,py312,py313,pypy310},
     nginx-external_httpx-{py37,py38,py39,py310,py311,py312,py313},
-    postgres16-datastore_asyncpg-{py37,py38,py39,py310,py311,py312},
-    ;; Package not ready for Python 3.13 (missing wheel)
-    ; postgres16-datastore_asyncpg-py313,
+    postgres16-datastore_asyncpg-{py37,py38,py39,py310,py311,py312,py313},
     postgres16-datastore_psycopg-{py38,py39,py310,py311,py312,py313,pypy310}-psycopglatest,
     postgres16-datastore_psycopg-py312-psycopg_{purepython,binary,compiled}0301,
     postgres16-datastore_psycopg2-{py37,py38,py39,py310,py311,py312}-psycopg2latest,
     postgres16-datastore_psycopg2cffi-{py37,py38,py39,py310,py311,py312}-psycopg2cffilatest,
-    postgres16-datastore_pyodbc-{py37,py38,py39,py310,py311,py312}-pyodbclatest,
-    ;; Package not ready for Python 3.13 (missing wheel)
-    ; postgres16-datastore_pyodbc-py313-pyodbclatest,
+    postgres16-datastore_pyodbc-{py37,py38,py39,py310,py311,py312,py313}-pyodbclatest,
     postgres9-datastore_postgresql-{py37,py38,py39},
     python-adapter_asgiref-{py37,py38,py39,py310,py311,py312,py313,pypy310}-asgireflatest,
     python-adapter_asgiref-py310-asgiref{0303,0304,0305,0306,0307},
     python-adapter_cheroot-{py37,py38,py39,py310,py311,py312,py313},
     python-adapter_daphne-{py37,py38,py39,py310,py311,py312,py313}-daphnelatest,
-    python-adapter_gevent-{py37,py38,py310,py311,py312},
-    ;; Package not ready for Python 3.13 (missing wheel)
-    ; python-adapter_gevent-py313,
+    python-adapter_gevent-{py37,py38,py310,py311,py312,py313},
     python-adapter_gunicorn-{py37,py38,py39,py310,py311,py312,py313}-aiohttp03-gunicornlatest,
     python-adapter_hypercorn-{py38,py39,py310,py311,py312,py313}-hypercornlatest,
     python-adapter_hypercorn-py38-hypercorn{0010,0011,0012,0013},
@@ -104,12 +96,10 @@ envlist =
     python-component_flask_rest-{py38,py39,py310,py311,py312,py313,pypy310}-flaskrestxlatest,
     python-component_flask_rest-py37-flaskrestx110,
     python-component_graphqlserver-{py37,py38,py39,py310,py311,py312},
-    ;; Package not ready for Python 3.13 (missing wheel for uvloop)
+    ;; Tests need to be updated to support newer graphql-server/sanic versions
     ; python-component_graphqlserver-py313,
     python-component_tastypie-{py37,py38,py39,py310,py311,py312,py313,pypy310}-tastypielatest,
-    python-coroutines_asyncio-{py37,py38,py39,py310,py311,py312,pypy310},
-    ;; Package not ready for Python 3.13 (missing wheel for uvloop)
-    ; python-coroutines_asyncio-py313,
+    python-coroutines_asyncio-{py37,py38,py39,py310,py311,py312,py313,pypy310},
     python-cross_agent-{py37,py38,py39,py310,py311,py312,py313}-{with,without}_extensions,
     python-datastore_sqlite-{py37,py38,py39,py310,py311,py312,py313,pypy310},
     python-external_aiobotocore-{py38,py39,py310,py311,py312,py313}-aiobotocorelatest,
@@ -131,9 +121,7 @@ envlist =
     python-framework_cherrypy-{py37,py38,py39,py310,py311,py312,py313,pypy310}-CherryPylatest,
     python-framework_django-{py37,py38,py39,py310,py311,py312,py313}-Djangolatest,
     python-framework_django-{py39}-Django{0202,0300,0301,0302,0401},
-    python-framework_falcon-{py37,py38,py39,py310,py311,py312,pypy310}-falconlatest,
-    ;; Package not ready for Python 3.13 (missing wheel)
-    ; python-framework_falcon-py313-falconlatest,
+    python-framework_falcon-{py37,py38,py39,py310,py311,py312,py313,pypy310}-falconlatest,
     python-framework_falcon-{py38,py39,py310,py311,py312,py313,pypy310}-falconmaster,
     python-framework_fastapi-{py37,py38,py39,py310,py311,py312,py313},
     python-framework_flask-py37-flask020205,
@@ -147,9 +135,7 @@ envlist =
     python-framework_graphql-py37-graphql{0301,0302},
     python-framework_pyramid-{py37,py38,py39,py310,py311,py312,py313,pypy310}-Pyramidlatest,
     python-framework_pyramid-{py37,py38,py39,py310,py311,py312,py313,pypy310}-Pyramid0110-cornice,
-    python-framework_sanic-{py37,py38,py39,py310,py311,py312,pypy310}-saniclatest,
-    ;; Package not ready for Python 3.13 (missing wheel for uvloop)
-    ; python-framework_sanic-py313-saniclatest,
+    python-framework_sanic-{py37,py38,py39,py310,py311,py312,py313,pypy310}-saniclatest,
     python-framework_sanic-{py38,pypy310}-sanic{200904,210300,2109,2112,2203,2290},
     python-framework_starlette-{py310,pypy310}-starlette{0014,0015,0019,0028},
     python-framework_starlette-{py37,py38,py39,py310,py311,py312,py313,pypy310}-starlettelatest,
@@ -162,7 +148,7 @@ envlist =
     python-logger_loguru-{py37,py38,py39,py310,py311,py312,py313,pypy310}-logurulatest,
     python-logger_structlog-{py37,py38,py39,py310,py311,py312,py313,pypy310}-structloglatest,
     python-mlmodel_langchain-{py39,py310,py311,py312},
-    ;; Package not ready for Python 3.13 (missing wheel for numpy)
+    ;; Package not ready for Python 3.13 (uses an older version of numpy)
     ; python-mlmodel_langchain-py313,
     python-mlmodel_openai-openai0-{py37,py38,py39,py310,py311,py312},
     python-mlmodel_openai-openai107-py312,