diff --git a/_collections/_labs/ciel_animal-facility.md b/_collections/_labs/ciel_animal-facility.md index 1a0a4a2..d7c1e96 100644 --- a/_collections/_labs/ciel_animal-facility.md +++ b/_collections/_labs/ciel_animal-facility.md @@ -4,7 +4,7 @@ title: ANIMAL FACILITY & WELFARE cat: ciel subcat: cell headline: Research topic -teasing: Difficulty on insensible reasonable in. From as went he they. Preference themselves me as thoroughly partiality considered on in estimating. Middletons acceptance discovered projecting so is so or. In or attachment inquietude remarkably comparison at an. Is surrounded prosperous stimulated am me discretion expression. But truth being state can she china widow. Occasional preference fat remarkably now projecting uncommonly dissimilar. Sentiments projection particular companions interested do at my delightful. Listening newspaper in advantage frankness to concluded unwilling. +teasing: Difficulty on insensible reasonable in. From as went he they. Preference themselves me as thoroughly partiality considered on in estimating. Middletons acceptance discovered projecting so is so or. In or attachment inquietude remarkably comparison at an. Is surrounded prosperous stimulated am me discretion expression. But truth being state can she china widow. Occasional preference fat remarkably now projecting uncommonly dissimilar. Sentiments projection particular companions interested do at my delightful. Listening newspaper in advantage frankness to concluded unwilling. leader: Sébastien Mériaux icon: added: 2020 diff --git a/_collections/_labs/ciel_animal-mri.md b/_collections/_labs/ciel_animal-mri.md index 1d4702b..2312555 100644 --- a/_collections/_labs/ciel_animal-mri.md +++ b/_collections/_labs/ciel_animal-mri.md @@ -24,4 +24,4 @@ The 11.7T preclinical MRI scanner, running under the responsibility of F. Boumez The 17.2T preclinical MRI scanner, running under the responsibility of L. Ciobanu from the “NeuroPhysics” research group, is one of the highest magnetic field horizontal bore preclinical system in the world. The clear bore inside the gradients (85 mm) allows the imaging of small animals (rats, mice). Besides the very high magnetic field, another feature of this system is the high strength of the magnetic field gradients, capable of reaching 1000 mT/m. With these gradients, it is possible to acquire very high spatial resolution images (25 µm isotropic). The 17.2T system is equipped with a variety of radiofrequency coils: surface, phased array and volume coils for rat and mouse brain imaging, as well as with microcoils with diameters between 700 µm and 2 mm for imaging small samples. X nuclei surface coils (13C, 31P) for spectroscopy studies are also available. -The system will be soon equipped with the AVANCE NEO electronics that offers improved shimming performances, faster gradient switching times and gradient linearity corrections ensuring better image quality. Secondly, a cryo-platform and a cryo-cooled deuterium coil (2H) will be purchased to open the way to novel explorations of metabolic events occurring in the brain. A helium recovery and liquefaction system will be installed to eliminate the need for helium supplies. \ No newline at end of file +The system will be soon equipped with the AVANCE NEO electronics that offers improved shimming performances, faster gradient switching times and gradient linearity corrections ensuring better image quality. Secondly, a cryo-platform and a cryo-cooled deuterium coil (2H) will be purchased to open the way to novel explorations of metabolic events occurring in the brain. A helium recovery and liquefaction system will be installed to eliminate the need for helium supplies. diff --git a/_collections/_labs/ciel_ciclops.md b/_collections/_labs/ciel_ciclops.md index c056836..f9d4afe 100644 --- a/_collections/_labs/ciel_ciclops.md +++ b/_collections/_labs/ciel_ciclops.md @@ -22,8 +22,8 @@ Beyond the signal of 1H2O, in vivo NMR of 1H and low gyrom While 1H2O is the focus of almost all MRI studies, several other molecules and ions exist whose NMR signals are much more informative regarding the biophysical, metabolic or physiological status of those tissues. Over the past years, I used 1H and 31P NMR Spectroscopy to quantify metabolites involved in neurotransmission and metabolism, such as neurotransmitters Glutamate and GABA or energy store/substrates Adenosine Tri-Phosphate and Lactate. Using dedicated fast ultra-short echo-time imaging sequences, I also investigated Sodium (23Na) ions whose transmembrane concentration gradient is maintained at great energy cost and plays a major role in establishing the neurons’ resting potential. -One of my recent research line is Lithium-7 MRI. Lithium salts are the main treatment for bipolar disorder, yet the mechanism of action remains a mystery, and 7Li MRI is the only technique allowing lithium non- invasive mapping and quantification in the brain. Dynamic 13C or 2H NMR are very interesting non-irradiating alternatives to \[18F]FDG-PET benefitting from their greater chemical/spectral specificities notably to discriminate and quantify aerobic vs. anaerobic energy synthesis pathways, neuronal and glial metabolism or even probe neurotransmission via the GABA and Glutamate synthesis and recycling rates. All of those weak signals benefit from the extremely high magnetic fields available at NeuroSpin enabling their investigation at better temporal and spatial resolutions. +One of my recent research line is Lithium-7 MRI. Lithium salts are the main treatment for bipolar disorder, yet the mechanism of action remains a mystery, and 7Li MRI is the only technique allowing lithium non- invasive mapping and quantification in the brain. Dynamic 13C or 2H NMR are very interesting non-irradiating alternatives to \[18F]FDG-PET benefitting from their greater chemical/spectral specificities notably to discriminate and quantify aerobic vs. anaerobic energy synthesis pathways, neuronal and glial metabolism or even probe neurotransmission via the GABA and Glutamate synthesis and recycling rates. All of those weak signals benefit from the extremely high magnetic fields available at NeuroSpin enabling their investigation at better temporal and spatial resolutions. My goal is to advance those methods and collaborate with biologists, physicians, bio-informaticians and neuroscientists to incorporate them within multimodal clinical and preclinical research protocols to better understand psychiatric and neurological diseases, their eventual treatments, and to develop novel biomarkers of disease progression or response to treatment. -In January 2024, Alfredo Lopez-Kolkovsky joined the CICLOPS group to accelerate the development of metabolic neuroimaging in particular on the 11.7T Iseult scanner. \ No newline at end of file +In January 2024, Alfredo Lopez-Kolkovsky joined the CICLOPS group to accelerate the development of metabolic neuroimaging in particular on the 11.7T Iseult scanner. diff --git a/_collections/_labs/ciel_histology.md b/_collections/_labs/ciel_histology.md index 67eef81..93638a9 100644 --- a/_collections/_labs/ciel_histology.md +++ b/_collections/_labs/ciel_histology.md @@ -59,7 +59,7 @@ The two most relevant ones (<5 years): - Jelescu, I.O., de Skowronski, A., Geffroy, F., Palomboe, M., Novikov, D. S., (2022) Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange Neuroimage 119277 2022 https://doi.org/10.1016/j.neuroimage.2022.119277 -- Conti, A., Geffroy, F., Kamimura, H. A. S., Novell, A., Tournier, N., Mériaux, S. and Larrat, B. (2023) Regulation of P-glycoprotein and Breast Cancer Resistance Protein Expression Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Disruption: A Pilot Study. International Journal of Molecular Sciences. 23, 15488 2022/ Int. J. Mol. Sci. 2022, 23, 15488. +- Conti, A., Geffroy, F., Kamimura, H. A. S., Novell, A., Tournier, N., Mériaux, S. and Larrat, B. (2023) Regulation of P-glycoprotein and Breast Cancer Resistance Protein Expression Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Disruption: A Pilot Study. International Journal of Molecular Sciences. 23, 15488 2022/ Int. J. Mol. Sci. 2022, 23, 15488. https://doi.org/10.3390/ijms232415488 diff --git a/_collections/_labs/ciel_midas.md b/_collections/_labs/ciel_midas.md index 896b456..8bb9d83 100644 --- a/_collections/_labs/ciel_midas.md +++ b/_collections/_labs/ciel_midas.md @@ -4,7 +4,7 @@ title: MIDAS cat: ciel subcat: team headline: Research topic -teasing: The blood-brain barrier (BBB) remains the bottleneck for pharmacological therapy of neurological diseases, costing billionsto our societies.The goal of our team isto provide new solutionsto deliver drugsto the brain in a safe way in order to increase their efficacy on the target.Transcranial focused ultrasound isa particularly promising technique to transiently and locally disrupt thisvascular barrier. Since 2010,we use neuroimaging to characterize the technology and to develop translational strategies. We now aim at making it a reality for the highest possible number of patients in the future years. +teasing: The blood-brain barrier (BBB) remains the bottleneck for pharmacological therapy of neurological diseases, costing billionsto our societies.The goal of our team isto provide new solutionsto deliver drugsto the brain in a safe way in order to increase their efficacy on the target.Transcranial focused ultrasound isa particularly promising technique to transiently and locally disrupt thisvascular barrier. Since 2010,we use neuroimaging to characterize the technology and to develop translational strategies. We now aim at making it a reality for the highest possible number of patients in the future years. leader: Benoit Larrat icon: midas-icon.png added: 2020 @@ -22,4 +22,4 @@ In the last years, our team has pursued technological developments as well as pr To be able to better model drug delivery, we have measured the diffusion properties of nanoparticles after their crossing of the BBB. On the technological side, we have implemented passive cavitation detection and feedback loop monitoring at high frame rate to ensure safety of the ultrasound procedure with a patented approach. We also introduced safe large volume BBB opening sequences for applications such as whole brain or hemispherical drug delivery. Regarding applications, we have demonstrated the interest of the technique in small animal models, mainly in neuro-oncology, Alzheimer’s disease and gene delivery fields. We showed the capabilities to increase significantly the local concentration of MRI contrast agents and PET tracers, of drug-loaded nanoparticles, of therapeutic antibodies and of adeno- associated viruses. To translate this to patients, we have built a public-private French consortium to design, assemble, and test a new prototype of clinical device. This system is robotized and neuro-navigated to make -it widely spreadable in hospitals. It is cost-effective and compatible with short ambulatory procedures in order to perform chronic sessions over months or years. During the course of this project, every technological feature has been validated in non-human primates. We now want to pursue its clinical development through a spin-off company. \ No newline at end of file +it widely spreadable in hospitals. It is cost-effective and compatible with short ambulatory procedures in order to perform chronic sessions over months or years. During the course of this project, every technological feature has been validated in non-human primates. We now want to pursue its clinical development through a spin-off company. diff --git a/_collections/_people/ciel_a-lopezkolkovsky.md b/_collections/_people/ciel_a-lopezkolkovsky.md index 7094e0f..e8c9660 100644 --- a/_collections/_people/ciel_a-lopezkolkovsky.md +++ b/_collections/_people/ciel_a-lopezkolkovsky.md @@ -7,4 +7,3 @@ subcat: ciclops avatar: a-lopezkolkovsky.png joined: 2024 --- - diff --git a/_collections/_people/ciel_b-larrat.md b/_collections/_people/ciel_b-larrat.md index 71f8b82..6475ad2 100644 --- a/_collections/_people/ciel_b-larrat.md +++ b/_collections/_people/ciel_b-larrat.md @@ -7,4 +7,3 @@ subcat: midas avatar: b-larrat.png joined: 2006 --- - diff --git a/_collections/_people/ciel_c-ressam.md b/_collections/_people/ciel_c-ressam.md index 7d15142..3224375 100644 --- a/_collections/_people/ciel_c-ressam.md +++ b/_collections/_people/ciel_c-ressam.md @@ -4,7 +4,6 @@ name: Camélia Ressam position: gradstudent cat: ciel subcat: neurophysics -avatar: +avatar: joined: 2023 --- - diff --git a/_collections/_people/ciel_d-boido.md b/_collections/_people/ciel_d-boido.md index f1ee4a9..baca148 100644 --- a/_collections/_people/ciel_d-boido.md +++ b/_collections/_people/ciel_d-boido.md @@ -8,4 +8,3 @@ avatar: d-boido.png site: https://davideboido.github.io joined: 2020 --- - diff --git a/_collections/_people/ciel_d-lebihan.md b/_collections/_people/ciel_d-lebihan.md index 3d35ece..c4dbe51 100644 --- a/_collections/_people/ciel_d-lebihan.md +++ b/_collections/_people/ciel_d-lebihan.md @@ -7,4 +7,3 @@ subcat: neurophysics avatar: d-lebihan.png joined: 2006 --- - diff --git a/_collections/_people/ciel_e-selingue.md b/_collections/_people/ciel_e-selingue.md index eb1098a..c801be8 100644 --- a/_collections/_people/ciel_e-selingue.md +++ b/_collections/_people/ciel_e-selingue.md @@ -7,4 +7,3 @@ subcat: midas avatar: e-selingue.png joined: 2006 --- - diff --git a/_collections/_people/ciel_f-boumezbeur.md b/_collections/_people/ciel_f-boumezbeur.md index 86381cf..5a06b7f 100644 --- a/_collections/_people/ciel_f-boumezbeur.md +++ b/_collections/_people/ciel_f-boumezbeur.md @@ -7,4 +7,3 @@ subcat: ciclops avatar: f-boumezbeur.png joined: 2006 --- - diff --git a/_collections/_people/ciel_f-geffroy.md b/_collections/_people/ciel_f-geffroy.md index 6020fae..2a98dc8 100644 --- a/_collections/_people/ciel_f-geffroy.md +++ b/_collections/_people/ciel_f-geffroy.md @@ -4,7 +4,6 @@ name: Françoise Geffroy position: pi cat: ciel subcat: midas -avatar: +avatar: joined: 2006 --- - diff --git "a/_collections/_people/ciel_g-pag\303\251.md" "b/_collections/_people/ciel_g-pag\303\251.md" index fc057a0..5c1036a 100644 --- "a/_collections/_people/ciel_g-pag\303\251.md" +++ "b/_collections/_people/ciel_g-pag\303\251.md" @@ -7,4 +7,3 @@ subcat: midas avatar: g-page.png joined: 2024 --- - diff --git a/_collections/_people/ciel_l-ciobanu.md b/_collections/_people/ciel_l-ciobanu.md index 4481313..6035298 100644 --- a/_collections/_people/ciel_l-ciobanu.md +++ b/_collections/_people/ciel_l-ciobanu.md @@ -7,4 +7,3 @@ subcat: neurophysics avatar: l-ciobanu.png joined: 2006 --- - diff --git a/_collections/_people/ciel_m-gay.md b/_collections/_people/ciel_m-gay.md index acae738..50f176e 100644 --- a/_collections/_people/ciel_m-gay.md +++ b/_collections/_people/ciel_m-gay.md @@ -4,7 +4,6 @@ name: Marion Gay position: engineer cat: ciel subcat: midas -avatar: +avatar: joined: 2022 --- - diff --git a/_collections/_people/ciel_m-glatigny.md b/_collections/_people/ciel_m-glatigny.md index 6fa0961..3ae6e4f 100644 --- a/_collections/_people/ciel_m-glatigny.md +++ b/_collections/_people/ciel_m-glatigny.md @@ -7,4 +7,3 @@ subcat: midas avatar: m-glatigny.png joined: 2022 --- - diff --git a/_collections/_people/ciel_r-gaudin.md b/_collections/_people/ciel_r-gaudin.md index 8a5fd1e..e4da743 100644 --- a/_collections/_people/ciel_r-gaudin.md +++ b/_collections/_people/ciel_r-gaudin.md @@ -7,4 +7,3 @@ subcat: neurophysics avatar: r-gaudin.png joined: 2023 --- - diff --git a/_collections/_people/ciel_s-meriaux.md b/_collections/_people/ciel_s-meriaux.md index 801c03e..b51e925 100644 --- a/_collections/_people/ciel_s-meriaux.md +++ b/_collections/_people/ciel_s-meriaux.md @@ -7,4 +7,3 @@ subcat: midas avatar: s-meriaux.png joined: 2006 --- - diff --git a/_collections/_people/ciel_t-tsurugizawa.md b/_collections/_people/ciel_t-tsurugizawa.md index 9afff8e..d4f1193 100644 --- a/_collections/_people/ciel_t-tsurugizawa.md +++ b/_collections/_people/ciel_t-tsurugizawa.md @@ -7,4 +7,3 @@ subcat: neurophysics avatar: joined: 2006 --- - diff --git a/_collections/_people/ciel_w-pianezzola.md b/_collections/_people/ciel_w-pianezzola.md index 7cab33a..9218232 100644 --- a/_collections/_people/ciel_w-pianezzola.md +++ b/_collections/_people/ciel_w-pianezzola.md @@ -4,7 +4,6 @@ name: Wilfried Pianezzola position: engineer cat: ciel subcat: midas -avatar: +avatar: joined: 2006 --- - diff --git a/biblio_other.md b/biblio_other.md index dccb8a9..e495b35 100644 --- a/biblio_other.md +++ b/biblio_other.md @@ -34,7 +34,7 @@ permalink: bibliography.html {% if entry.doi %} {% capture title %}{{entry.title}}{% endcapture %} {% else %} - {% assign title = {{entry.title}} %} + {% assign title = {{entry.title}} %} {% endif %} {% if entry.journal %} {{entry.author}}: {{title}}, {{entry.journal}} ({{entry.year}}) @@ -51,4 +51,3 @@ permalink: bibliography.html
{% endfor %} - diff --git a/biblio_selected.md b/biblio_selected.md index 938767c..5078354 100644 --- a/biblio_selected.md +++ b/biblio_selected.md @@ -19,7 +19,7 @@ permalink: bibliography/bestof.html {% if entry.doi %} {% capture title %}{{entry.title}}{% endcapture %} {% else %} - {% assign title = {{entry.title}} %} + {% assign title = {{entry.title}} %} {% endif %} {% if entry.journal %} {{entry.author}}: {{title}}, {{entry.journal}} ({{entry.year}}) @@ -34,5 +34,3 @@ permalink: bibliography/bestof.html {% endfor %}
- - diff --git a/index.md b/index.md index 1511aa2..f0e2548 100644 --- a/index.md +++ b/index.md @@ -18,7 +18,7 @@ layout: page_lab

- Therefore, the global scientific strategy of CIEL consists in building a framework of imaging technologies that are increasing the comprehension of fundamental mechanisms underlying brain functioning, but also in producing new diagnostic and therapeutic tools in a pathological context such as brain tumor, stroke, neurodegenerative and psychiatric diseases. + Therefore, the global scientific strategy of CIEL consists in building a framework of imaging technologies that are increasing the comprehension of fundamental mechanisms underlying brain functioning, but also in producing new diagnostic and therapeutic tools in a pathological context such as brain tumor, stroke, neurodegenerative and psychiatric diseases.

Below is a list of all the teams and cells. A gallery of current research topics is also available. @@ -51,4 +51,3 @@ layout: page_lab "/> - diff --git a/members.md b/members.md index 8704203..029fac7 100644 --- a/members.md +++ b/members.md @@ -18,8 +18,8 @@ permalink: /people/ {% endfor %} {% assign people_valid = people_valid | push: listpeople %} {% endfor %} - - + +

{% assign i = 0 %} {% for item in people_array %} diff --git a/opportunities.md b/opportunities.md index e5f0c15..bf064cc 100644 --- a/opportunities.md +++ b/opportunities.md @@ -29,7 +29,7 @@ For a spontaneous application do not hesitate to {% assign i = 0 %} {% for item in jobs_array %} @@ -68,4 +68,3 @@ For a spontaneous application do not hesitate to -