2024-04-18-buch24a.md

title	software	abstract	layout	series	publisher	issn	id	month	tex_title	firstpage	lastpage	page	order	cycles	bibtex_author	author	date	address	container-title	volume	genre	issued	pdf	extras
Simple and scalable algorithms for cluster-aware precision medicine	https://github.com/CARVE-AI	AI-enabled precision medicine promises a transformational improvement in healthcare outcomes. However, training on biomedical data presents significant challenges as they are often high dimensional, clustered, and of limited sample size. To overcome these challenges, we propose a simple and scalable approach for cluster-aware embedding that combines latent factor methods with a convex clustering penalty in a modular way. Our novel approach overcomes the complexity and limitations of current joint embedding and clustering methods and enables hierarchically clustered principal component analysis (PCA), locally linear embedding (LLE), and canonical correlation analysis (CCA). Through numerical experiments and real-world examples, we demonstrate that our approach outperforms fourteen clustering methods on highly underdetermined problems (e.g., with limited sample size) as well as on large sample datasets. Importantly, our approach does not require the user to choose the desired number of clusters, yields improved model selection if they do, and yields interpretable hierarchically clustered embedding dendrograms. Thus, our approach improves significantly on existing methods for identifying patient subgroups in multiomics and neuroimaging data and enables scalable and interpretable biomarkers for precision medicine.	inproceedings	Proceedings of Machine Learning Research	PMLR	2640-3498	buch24a	0	Simple and scalable algorithms for cluster-aware precision medicine	136	144	136-144	136	false	Buch, Amanda M. and Liston, Conor and Grosenick, Logan	given family Amanda M. Buch given family Conor Liston given family Logan Grosenick	2024-04-18		Proceedings of The 27th International Conference on Artificial Intelligence and Statistics	238	inproceedings	date-parts 2024 4 18	https://proceedings.mlr.press/v238/buch24a/buch24a.pdf