diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index 0cf9a066e11bd..d7fc4ce21ca87 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -651,6 +651,9 @@ def empty(self):
     def __nonzero__(self):
         return not self.empty
 
+    # Python 3 compat
+    __bool__ = __nonzero__
+
     @property
     def ndim(self):
         return self._data.ndim
diff --git a/pandas/core/internals.py b/pandas/core/internals.py
index e2b3131fac9ce..21cfa8658b03c 100644
--- a/pandas/core/internals.py
+++ b/pandas/core/internals.py
@@ -1016,6 +1016,9 @@ def make_empty(self):
     def __nonzero__(self):
         return True
 
+    # Python3 compat
+    __bool__ = __nonzero__
+
     @property
     def ndim(self):
         return len(self.axes)