diff --git a/src/material/slider/slider-input.ts b/src/material/slider/slider-input.ts
index f357d9dbabc8..898c46ee6f8f 100644
--- a/src/material/slider/slider-input.ts
+++ b/src/material/slider/slider-input.ts
@@ -637,7 +637,7 @@ export class MatSliderRangeThumb extends MatSliderThumb implements _MatSliderRan
   }
 
   override _onPointerDown(event: PointerEvent): void {
-    if (this.disabled) {
+    if (this.disabled || event.button !== 0) {
       return;
     }
     if (this._sibling) {
diff --git a/src/material/slider/slider-thumb.ts b/src/material/slider/slider-thumb.ts
index 72b902a2fbf6..858465cc5200 100644
--- a/src/material/slider/slider-thumb.ts
+++ b/src/material/slider/slider-thumb.ts
@@ -172,7 +172,10 @@ export class MatSliderVisualThumb implements _MatSliderVisualThumb, AfterViewIni
     this._hostElement.classList.remove('mdc-slider__thumb--focused');
   };
 
-  private _onDragStart = (): void => {
+  private _onDragStart = (event: PointerEvent): void => {
+    if (event.button !== 0) {
+      return;
+    }
     this._isActive = true;
     this._showActiveRipple();
   };