Beetle PC Engine Fast is a port/fork of Mednafen's PC Engine Fast "pce_fast" module to the libretro API. This libretro core contains CD-ROM2 support but unlike Mednafen's PCE Fast module, lacks SuperGrafx support. SuperGrafx support is available in the Beetle SuperGrafx core or the Beetle PC Engine "pce" core.
This core can be built with make.
https://docs.libretro.com/library/beetle_pce_fast/
Beetle PC Engine: https://github.com/libretro/beetle-pce-libretro
Beetle SuperGrafx: https://github.com/libretro/beetle-supergrafx-libretro