From 22774c68e4f5b7b44375adbb81054179b52d9c14 Mon Sep 17 00:00:00 2001 From: lgmgeo Date: Fri, 16 Feb 2024 22:15:53 +0100 Subject: [PATCH] New official release: 3.4 --- .gitignore | 10 +- Makefile | 27 +- README.AnnotSV_3.3.6.pdf | Bin 1843391 -> 0 bytes README.AnnotSV_3.4.pdf | Bin 0 -> 2107196 bytes README.AnnotSV_latest.pdf | 1 - README.md | 12 +- Scoring_Criteria_AnnotSV_latest.xlsx | 1 - Scoring_Criteria_AnnotSV_v3.3.xlsx | Bin 25386 -> 0 bytes Scoring_Criteria_AnnotSV_v3.4.xlsx | Bin 0 -> 25544 bytes bin/AnnotSV | 2 +- changeLog.txt | 25 +- docs/images/AnnotSV_logo.png | Bin 93250 -> 0 bytes etc/AnnotSV/application.properties | 4 +- share/bash/AnnotSV/checkPhenoGeniusInstall.sh | 5 +- .../Example/test_GRCh37.annotated.example.tsv | 1094 +++--- share/doc/AnnotSV/Images/AnnotSV_logo.png | Bin .../doc/AnnotSV/Images}/AnnotSV_overview.jpg | Bin .../doc/AnnotSV/Images}/gpl.png | Bin {docs => share/doc/AnnotSV}/annotations.md | 4 +- {docs => share/doc/AnnotSV}/quickstart.md | 2 +- 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rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv2.vcf (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv3.vcf (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra1.vcf (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra2.vcf (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input-tra1.bed (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_1.vcf (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_partial_pass.vcf (100%) rename tests/{data => AnnotSV}/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_unordered.vcf (100%) rename tests/{data => 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rename tests/{data => AnnotSV}/test_35_phenogenius/input/PKD1.bed (100%) rename tests/{data => AnnotSV}/test_35_phenogenius/input/test.bed (100%) delete mode 100755 tests/data/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv delete mode 100644 tests/data/test_11_RamTracking/ramAnnotSV-ena-ram.txt delete mode 100644 tests/data/test_11_RamTracking/tutu.log delete mode 100644 tests/data/test_13_txFile/3 delete mode 100755 tests/data/test_13_txFile/command_Tcl.sh delete mode 100755 tests/data/test_29_distNearestSS/input/test1.vcf delete mode 100755 tests/data/test_29_distNearestSS/input/test6.bed diff --git a/.gitignore b/.gitignore index a3c4770..d55132c 100644 --- a/.gitignore +++ b/.gitignore @@ -18,12 +18,10 @@ Python/ share/python3/phenogenius/ # Unit tests -tests/data/check_all_public_test_directory.log -tests/data/privateTest_* -tests/data/test_*/command_Tcl.log -tests/data/test_*/output/ -tests/data/ToDo -tests/data/test_37_bracketedToAngularNotation/Rodrigo_tests_ignore +tests/AnnotSV/privateTest_* +tests/AnnotSV/test_*/command_Tcl.log +tests/AnnotSV/test_*/output/ +tests/AnnotSV/ToDo # VariantConvert share/python3/variantconvert/pipinstall.flag diff --git a/Makefile b/Makefile index 08f92eb..c111075 100644 --- a/Makefile +++ b/Makefile @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -33,13 +33,14 @@ ETCDIR := $(PREFIX)/etc SHAREDIR := $(PREFIX)/share DOCDIR := $(SHAREDIR)/doc BASHDIR := $(SHAREDIR)/bash +TESTSDIR := $(PREFIX)/tests TCLVERSION := tcl$(shell echo 'puts $${tcl_version};exit 0' | tclsh) TCLDIRDISTRIBUTED := share/tcl TCLDIR := $(SHAREDIR)/$(TCLVERSION) PYTHONDIRDISTRIBUTED := share/python3 PYTHONDIR := $(SHAREDIR)/python3 ANNOTSV := AnnotSV -VERSION := 3.3.6 +VERSION := 3.4 RM := /bin/rm RMDIR := /bin/rmdir MKDIR := install -d @@ -118,8 +119,9 @@ install-variantconvert: @echo "---------------------------" touch $(DESTDIR)$(PYTHONDIR)/variantconvert/pipinstall.flag chmod 777 $(DESTDIR)$(PYTHONDIR)/variantconvert/pipinstall.flag - pip3 install -e $(DESTDIR)$(PYTHONDIR)/variantconvert/. || pip install -e $(DESTDIR)$(PYTHONDIR)/variantconvert/. || rm -f $(DESTDIR)$(PYTHONDIR)/variantconvert/pipinstall.flag - @echo "" + pip3 install -e $(DESTDIR)$(PYTHONDIR)/variantconvert/. &> ./tmp.variantconvert.txt || pip install -e $(DESTDIR)$(PYTHONDIR)/variantconvert/. &> ./tmp.variantconvert.txt || rm -f $(DESTDIR)$(PYTHONDIR)/variantconvert/pipinstall.flag + rm -f ./tmp.variantconvert.txt + ls -l $(DESTDIR)$(PYTHONDIR)/variantconvert/pipinstall.flag || echo "variantconvert not installed" touch $(DESTDIR)$(PYTHONDIR)/variantconvert/configs/GRCh37/annotsv3_from_bed.local.json touch $(DESTDIR)$(PYTHONDIR)/variantconvert/configs/GRCh38/annotsv3_from_bed.local.json $(CHMOD) $(DESTDIR)$(PYTHONDIR)/variantconvert/configs/GRCh37/annotsv3_from_bed.local.json @@ -165,15 +167,15 @@ install-human-annotation: Annotations_Human_$(VERSION).tar.gz install-exomiser @echo "" @echo "--> Human annotation installed" -install-exomiser-1: 2202_phenotype.zip +install-exomiser-1: 2309_phenotype.zip @echo "" @echo "Installation of Exomiser data:" @echo "" - $(MKDIR) -p $(DESTDIR)$(SHAREDIR)/$(ANNOTSV)/Annotations_Exomiser/2202 - tar -xf 2202_hg19.tar.gz -C $(DESTDIR)$(SHAREDIR)/$(ANNOTSV)/Annotations_Exomiser/2202/ - unzip 2202_phenotype.zip -d $(DESTDIR)$(SHAREDIR)/$(ANNOTSV)/Annotations_Exomiser/2202/ - $(RM) -rf 2202_phenotype.zip - $(RM) -rf 2202_hg19.tar.gz + $(MKDIR) -p $(DESTDIR)$(SHAREDIR)/$(ANNOTSV)/Annotations_Exomiser/2309 + tar -xf 2309_hg19.tar.gz -C $(DESTDIR)$(SHAREDIR)/$(ANNOTSV)/Annotations_Exomiser/2309/ + unzip 2309_phenotype.zip -d $(DESTDIR)$(SHAREDIR)/$(ANNOTSV)/Annotations_Exomiser/2309/ + $(RM) -rf 2309_phenotype.zip + $(RM) -rf 2309_hg19.tar.gz install-exomiser-2: install -p -m 0755 $(PROPERTIES) $(DESTDIR)$(ETCDIR)/$(ANNOTSV) @@ -203,7 +205,7 @@ Annotations_%.tar.gz: @echo "" @echo "Download Exomiser supporting data files:" @echo "" - curl -C - -LO https://www.lbgi.fr/~geoffroy/Annotations/2202_hg19.tar.gz + curl -C - -LO https://www.lbgi.fr/~geoffroy/Annotations/2309_hg19.tar.gz curl -C - -LO https://data.monarchinitiative.org/exomiser/data/$@ @@ -232,6 +234,7 @@ uninstall1: $(RM) -rf $(DESTDIR)$(SHAREDIR)/$(ANNOTSV) $(RM) -rf $(DESTDIR)$(BASHDIR)/$(ANNOTSV) $(RM) -rf $(DESTDIR)$(ETCDIR)/$(ANNOTSV) + $(RM) -rf $(DESTDIR)$(TESTSDIR)/$(ANNOTSV) $(RM) -rf $(DESTDIR)$(PREFIX)/Makefile $(RM) -rf $(DESTDIR)$(PREFIX)/README.md $(RM) -rf $(DESTDIR)$(PREFIX)/Scoring_Criteria_AnnotSV_*.xlsx @@ -239,7 +242,7 @@ uninstall1: $(RM) -rf $(DESTDIR)$(PREFIX)/.gitignore uninstall2: - $(RMDIR) --ignore-fail-on-non-empty $(DESTDIR)$(BINDIR) $(DESTDIR)$(BASHDIR) $(DESTDIR)$(TCLDIR) $(DESTDIR)$(PYTHONDIR) $(DESTDIR)$(DOCDIR) 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b/README.AnnotSV_latest.pdf deleted file mode 120000 index b84fc34..0000000 --- a/README.AnnotSV_latest.pdf +++ /dev/null @@ -1 +0,0 @@ -README.AnnotSV_3.3.6.pdf \ No newline at end of file diff --git a/README.md b/README.md index 8a6414b..ce1192b 100644 --- a/README.md +++ b/README.md @@ -1,5 +1,5 @@

    - +
    @@ -12,12 +12,12 @@ # Table of contents - ## AnnotSV Annotations Engine - - ### [README](README.AnnotSV_latest.pdf) - - ### [Getting Started](docs/quickstart.md) - - ### [Ranking](docs/ranking.md) - - ### [Annotations](docs/annotations.md) + - ### [README](README.AnnotSV_3.4.pdf) + - ### [Getting Started](share/doc/AnnotSV/quickstart.md) + - ### [Ranking](share/doc/AnnotSV/ranking.md) + - ### [Annotations](share/doc/AnnotSV/annotations.md) - ## AnnotSV Webserver - - ### [Overview](docs/webserver_overview.md) + - ### [Overview](share/doc/AnnotSV/webserver_overview.md)
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and then tries to find neighboring genes - In both directions, the closest gene to the SV is reported - - Add new phenotype prioritization method: PhenoGenius (Yauy et al., 2023, doi: 10.1101/2022.07.29.22278181) - - Add 3 new features: PhenoGenius_score, PhenoGenius_phenotype and PhenoGenius_specificity - - Gene names are now sorted by genomic coordinates and no longer sorted alphabetically ("Gene_name" feature) +February, 16, 2024, AnnotSV version 3.4 + - Human annotation update - Add new regulatory elements annotations: - Activity-by-Contact (ABC) model annotations (doi: 10.1038/s41586-021-03446-x) - Massively Parallel Reporter assays (MPRA) annotations (doi: 10.1038/s41467-019-11526-w) @@ -25,9 +19,20 @@ February, , 2024, AnnotSV version 3.4 - from gnomad v4 (GRCh38) (issue 201) - from the Human Pangenome Reference Consortium (HPRC) dataset (PACBIO long reads, GRCh38 only) (issue 202) - from dbVar (NCBI’s database of genomic structural variation) + - Add new phenotype prioritization method: PhenoGenius (Yauy et al., 2023, doi: 10.1101/2022.07.29.22278181) + - Add 3 new features: PhenoGenius_score, PhenoGenius_phenotype and PhenoGenius_specificity + - Add 4 new features: + - Closest_left and Closest_right + AnnotSV expands the SV up to 5 megabases in both direction (left and right) and then tries to find neighboring genes + In both directions, the closest gene to the SV is reported + - NCBI_gene_ID + - Tx_version (transcript version) + - Gene names are now sorted by genomic coordinates and no longer sorted alphabetically ("Gene_name" feature) + - Fix a bug when setting the cytoband annotation (issue 210) - Fix misleading OMIM annotation (issues 156, 132) - - Add "NCBI_gene_ID" and "Tx_version" annotations + - Update of the Makefile - Update of the "contact" recommendations in output (from email to GitHub) + - Reorganization of the GitHub .md files January, 15, 2024, AnnotSV version 3.3.9 - Fix a bug when setting the "hpoVersion" variable (issue 207) 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../poetry_install.log ;# Can be run from different servers - if [ `poetry run python phenogenius_cli.py --help | grep -c -- "--hpo_list"` ] + if [ `poetry run python phenogenius_cli.py --help | grep -c -- "--hpo_list"` == 1 ] then exit 0 else @@ -55,3 +55,4 @@ else fi fi + diff --git a/share/doc/AnnotSV/Example/test_GRCh37.annotated.example.tsv b/share/doc/AnnotSV/Example/test_GRCh37.annotated.example.tsv index 3465630..85b576e 100644 --- a/share/doc/AnnotSV/Example/test_GRCh37.annotated.example.tsv +++ b/share/doc/AnnotSV/Example/test_GRCh37.annotated.example.tsv @@ -1,554 +1,540 @@ -AnnotSV_ID SV_chrom SV_start SV_end SV_length SV_type Biologist_annotation Biologist_ranking Samples_ID Annotation_mode CytoBand Gene_name Gene_count Tx Tx_start Tx_end Overlapped_tx_length Overlapped_CDS_length Overlapped_CDS_percent Frameshift Exon_count Location Location2 Dist_nearest_SS Nearest_SS_type Intersect_start Intersect_end RE_gene P_gain_phen P_gain_hpo P_gain_source P_gain_coord P_loss_phen P_loss_hpo P_loss_source P_loss_coord P_ins_phen P_ins_hpo P_ins_source P_ins_coord po_P_gain_phen po_P_gain_hpo po_P_gain_source po_P_gain_coord po_P_gain_percent po_P_loss_phen po_P_loss_hpo po_P_loss_source po_P_loss_coord po_P_loss_percent P_snvindel_nb P_snvindel_phen B_gain_source B_gain_coord B_gain_AFmax B_loss_source B_loss_coord B_loss_AFmax B_ins_source B_ins_coord B_ins_AFmax B_inv_source B_inv_coord B_inv_AFmax po_B_gain_allG_source po_B_gain_allG_coord po_B_gain_someG_source po_B_gain_someG_coord po_B_loss_allG_source po_B_loss_allG_coord po_B_loss_someG_source po_B_loss_someG_coord Cosmic_ID Cosmic_mut_typ GC_content_left GC_content_right Repeat_coord_left Repeat_type_left Repeat_coord_right Repeat_type_right Gap_left Gap_right SegDup_left SegDup_right ENCODE_blacklist_left ENCODE_blacklist_characteristics_left ENCODE_blacklist_right ENCODE_blacklist_characteristics_right ACMG HI TS DDD_HI_percent ExAC_delZ ExAC_dupZ ExAC_cnvZ ExAC_synZ ExAC_misZ GenCC_disease GenCC_moi GenCC_classification GenCC_pmid OMIM_ID OMIM_phenotype OMIM_inheritance OMIM_morbid OMIM_morbid_candidate LOEUF_bin GnomAD_pLI ExAC_pLI AnnotSV_ranking_score AnnotSV_ranking_criteria ACMG_class -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA full q11.21 AIFM3;ARVCF;BCRP2;C22orf39;CCDC188;CDC45;CLDN5;CLTCL1;COMT;CRKL;DGCR11;DGCR2;DGCR5;DGCR6;DGCR6L;DGCR8;ESS2;FAM230A;FAM230G;FAM230J;GGTLC3;GNB1L;GP1BB;GSC2;HIRA;KLHL22;LINC00895;LINC00896;LINC01311;LINC01637;LOC102724770;LOC102724788;LOC107987389;LOC107987394;LOC284865;LRRC74B;LZTR1;MED15;MIR1286;MIR1306;MIR185;MIR3618;MIR4761;MIR649;MIR6816;MRPL40;P2RX6;P2RX6P;PI4KA;PI4KAP1;POM121L4P;PRODH;RANBP1;RIMBP3;RTL10;RTN4R;SCARF2;SEPT5-GP1BB;SEPTIN5;SERPIND1;SLC25A1;SLC7A4;SNAP29;SNORA77B;TANGO2;TBX1;THAP7;THAP7-AS1;TMEM191A;TMEM191B;TRMT2A;TSSK2;TUBA3FP;TXNRD2;UFD1;ZDHHC8;ZNF74 77 ABL1 (morbid/RE=mTL_miRNA);ACTN4 (morbid/RE=mTL_miRNA);ACVR2B (morbid/RE=mTL_miRNA);ADAR (morbid/RE=mTL_miRNA);ADH5 (morbid/RE=mTL_miRNA);AFF2 (HI=3/morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AHI1 (morbid/RE=mTL_miRNA);AKT1 (morbid/RE=mTL_miRNA);ALG1 (morbid/RE=mTL_miRNA);AMH (morbid/RE=mTL_miRNA);APCDD1 (morbid/RE=mTL_miRNA);AR (HI=3/morbid/RE=mTL_miRNA);ARID1A (HI=3/morbid/RE=mTL_miRNA);ASH1L (HI=3/morbid/RE=mTL_miRNA);ATM (HI=3/morbid/RE=mTL_miRNA);ATP6AP1 (morbid/RE=mTL_miRNA);ATP6V0A2 (morbid/RE=mTL_miRNA);ATR (morbid/RE=mTL_miRNA);B4GALT1 (morbid/RE=mTL_miRNA);BACH1 (morbid/RE=mTL_miRNA);BAP1 (HI=3/morbid/RE=mTL_miRNA);BBS5 (morbid/RE=mTL_miRNA);BCL10 (morbid/RE=mTL_miRNA);BMPR1A (HI=3/morbid/RE=mTL_miRNA);BNC2 (morbid/RE=mTL_miRNA);C3 (morbid/RE=mTL_miRNA);CACNA1C (morbid/RE=mTL_miRNA);CAD (morbid/RE=mTL_miRNA);CALM3 (morbid/RE=mTL_miRNA);CAPN15 (morbid/RE=mTL_miRNA);CASP14 (morbid/RE=mTL_miRNA);CBL (morbid/RE=mTL_miRNA);CCDC134 (morbid/RE=mTL_miRNA);CCND2 (morbid/RE=mTL_miRNA);CDC42 (morbid/RE=mTL_miRNA);CEP104 (morbid/RE=mTL_miRNA);CERS1 (morbid/RE=mTL_miRNA);CHRDL1 (HI=3/morbid/RE=mTL_miRNA);CLCC1 (morbid/RE=mTL_miRNA);CLCN7 (morbid/RE=mTL_miRNA);CLDN16 (morbid/RE=mTL_miRNA);CLPB (morbid/RE=mTL_miRNA);CNBP (morbid/RE=mTL_miRNA);CNNM4 (morbid/RE=mTL_miRNA);CNOT3 (morbid/RE=mTL_miRNA);CNTNAP2 (morbid/RE=mTL_miRNA);COCH (morbid/RE=mTL_miRNA);COL1A1 (HI=3/morbid/RE=mTL_miRNA);COPB1 (morbid/RE=mTL_miRNA);CWF19L1 (morbid/RE=mTL_miRNA);CYCS (morbid/RE=mTL_miRNA);DDHD1 (morbid/RE=mTL_miRNA);DDX11 (morbid/RE=mTL_miRNA);DGKE (morbid/RE=mTL_miRNA);DIAPH1 (morbid/RE=mTL_miRNA);DMPK (morbid/RE=mTL_miRNA);DNM2 (morbid/RE=mTL_miRNA);DNMT1 (morbid/RE=mTL_miRNA);DZIP1L (morbid/RE=mTL_miRNA);EDAR (morbid/RE=mTL_miRNA);EIF2S3 (morbid/RE=mTL_miRNA);ELOVL1 (morbid/RE=mTL_miRNA);EMC10 (morbid/RE=mTL_miRNA);ENG (HI=3/morbid/RE=mTL_miRNA);EPAS1 (morbid/RE=mTL_miRNA);EPHA2 (morbid/RE=mTL_miRNA);EZH2 (morbid/RE=mTL_miRNA);F2 (morbid/RE=mTL_miRNA);FADS1 (morbid/RE=mTL_miRNA);FGFR1 (HI=3/morbid/RE=mTL_miRNA);FOLR1 (morbid/RE=mTL_miRNA);FOXP1 (HI=3/morbid/RE=mTL_miRNA);FREM1 (morbid/RE=mTL_miRNA);FRMPD4 (morbid/RE=mTL_miRNA);FZD2 (morbid/RE=mTL_miRNA);GALM (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GBA2 (morbid/RE=mTL_miRNA);GFPT1 (morbid/RE=mTL_miRNA);GIPC1 (morbid/RE=mTL_miRNA);GJB1 (morbid/RE=mTL_miRNA);GLUD1 (morbid/RE=mTL_miRNA);GLUL (morbid/RE=mTL_miRNA);GM2A (morbid/RE=mTL_miRNA);GNAI2 (morbid/RE=mTL_miRNA);GNAL (morbid/RE=mTL_miRNA);GON7 (morbid/RE=mTL_miRNA);GRK1 (morbid/RE=mTL_miRNA);GRM6 (morbid/RE=mTL_miRNA);GSR (morbid/RE=mTL_miRNA);HAAO (morbid/RE=mTL_miRNA);HACE1 (morbid/RE=mTL_miRNA);HINT1 (morbid/RE=mTL_miRNA);HLCS (morbid/RE=mTL_miRNA);HMGA2 (morbid/RE=mTL_miRNA);HNRNPA1 (morbid/RE=mTL_miRNA);HNRNPK (HI=3/morbid/RE=mTL_miRNA);HNRNPU (morbid/RE=mTL_miRNA);IDS (HI=3/morbid/RE=mTL_miRNA);IFNAR1 (morbid/RE=mTL_miRNA);IGF1R (morbid/RE=mTL_miRNA);IGF2R (morbid/RE=mTL_miRNA);IKBKG (HI=3/morbid/RE=mTL_miRNA);IL10RA (morbid/RE=mTL_miRNA);ISCU (morbid/RE=mTL_miRNA);JAG2 (morbid/RE=mTL_miRNA);KCND3 (morbid/RE=mTL_miRNA);KCNH2 (HI=3/morbid/RE=mTL_miRNA);KCNK3 (morbid/RE=mTL_miRNA);KDM6B (morbid/RE=mTL_miRNA);KIAA1109 (morbid/RE=mTL_miRNA);KIAA1549 (morbid/RE=mTL_miRNA);KITLG (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KLHL7 (morbid/RE=mTL_miRNA);KMT2A (HI=3/morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);KRT74 (morbid/RE=mTL_miRNA);L2HGDH (morbid/RE=mTL_miRNA);LMNB2 (morbid/RE=mTL_miRNA);MAPK1 (morbid/RE=mTL_miRNA);MAPK8IP3 (morbid/RE=mTL_miRNA);MAPKBP1 (morbid/RE=mTL_miRNA);MATR3 (morbid/RE=mTL_miRNA);MCC (morbid/RE=mTL_miRNA);MCFD2 (morbid/RE=mTL_miRNA);MCM10 (morbid/RE=mTL_miRNA);MECP2 (HI=3/morbid/RE=mTL_miRNA);MED12L (morbid/RE=mTL_miRNA);MED17 (morbid/RE=mTL_miRNA);MPV17 (morbid/RE=mTL_miRNA);MRAS (morbid/RE=mTL_miRNA);MRE11 (morbid/RE=mTL_miRNA);MRPL44 (morbid/RE=mTL_miRNA);MSL3 (morbid/RE=mTL_miRNA);MTHFD1 (morbid/RE=mTL_miRNA);MYC (morbid/RE=mTL_miRNA);MYH14 (morbid/RE=mTL_miRNA);MYO5A (morbid/RE=mTL_miRNA);NACC1 (morbid/RE=mTL_miRNA);NANOS1 (morbid/RE=mTL_miRNA);NDST1 (morbid/RE=mTL_miRNA);NECTIN1 (morbid/RE=mTL_miRNA);NEUROD1 (morbid/RE=mTL_miRNA);NEUROD2 (morbid/RE=mTL_miRNA);NF2 (HI=3/morbid/RE=mTL_miRNA);NKAP (morbid/RE=mTL_miRNA);NRL (morbid/RE=mTL_miRNA);NUMA1 (morbid/RE=mTL_miRNA);NUS1 (morbid/RE=mTL_miRNA);OGT (morbid/RE=mTL_miRNA);PACS1 (morbid/RE=mTL_miRNA);PDHA1 (HI=3/morbid/RE=mTL_miRNA);PDZD8 (morbid/RE=mTL_miRNA);PERP (morbid/RE=mTL_miRNA);PEX26 (morbid/RE=EA_enhancer+mTL_miRNA);PHF8 (HI=3/morbid/RE=mTL_miRNA);PISD (morbid/RE=mTL_miRNA);PITX3 (morbid/RE=mTL_miRNA);PKD1 (HI=3/morbid/RE=mTL_miRNA);PLCD1 (morbid/RE=mTL_miRNA);POFUT1 (morbid/RE=mTL_miRNA);POLR3K (morbid/RE=mTL_miRNA);POMGNT1 (morbid/RE=mTL_miRNA);POU3F3 (morbid/RE=mTL_miRNA);PPP1R12A (morbid/RE=mTL_miRNA);PPP2CA (morbid/RE=mTL_miRNA);PPP2R1B (morbid/RE=mTL_miRNA);PPP2R5D (morbid/RE=mTL_miRNA);PRRT2 (HI=3/morbid/RE=mTL_miRNA);PUM1 (morbid/RE=mTL_miRNA);PUS3 (morbid/RE=mTL_miRNA);QRSL1 (morbid/RE=mTL_miRNA);RAB11B (morbid/RE=mTL_miRNA);RHOA (morbid/RE=mTL_miRNA);RNF170 (morbid/RE=mTL_miRNA);RTN2 (morbid/RE=mTL_miRNA);SALL4 (HI=3/morbid/RE=mTL_miRNA);SBF1 (morbid/RE=mTL_miRNA);SCD (morbid/RE=mTL_miRNA);SCN2B (morbid/RE=mTL_miRNA);SCUBE3 (morbid/RE=mTL_miRNA);SELENON (morbid/RE=mTL_miRNA);SERPINC1 (morbid/RE=mTL_miRNA);SET (morbid/RE=mTL_miRNA);SETD1B (morbid/RE=mTL_miRNA);SF1 (morbid/RE=mTL_miRNA);SGCD (morbid/RE=mTL_miRNA);SH3TC2 (morbid/RE=mTL_miRNA);SHROOM4 (morbid/RE=mTL_miRNA);SIX1 (morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC10A7 (morbid/RE=mTL_miRNA);SLC4A1 (morbid/RE=mTL_miRNA);SLC6A17 (morbid/RE=mTL_miRNA);SLC9A1 (morbid/RE=mTL_miRNA);SLC9A7 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SOX4 (morbid/RE=mTL_miRNA);SPATA5 (morbid/RE=mTL_miRNA);SPPL2A (morbid/RE=mTL_miRNA);SPRY4 (morbid/RE=mTL_miRNA);SRCAP (morbid/RE=mTL_miRNA);SRD5A3 (morbid/RE=mTL_miRNA);SREBF1 (morbid/RE=mTL_miRNA);STIM1 (morbid/RE=mTL_miRNA);STK4 (morbid/RE=mTL_miRNA);SUOX (morbid/RE=mTL_miRNA);SYT2 (morbid/RE=mTL_miRNA);TAOK1 (morbid/RE=mTL_miRNA);TBL1X (morbid/RE=mTL_miRNA);TEAD1 (morbid/RE=mTL_miRNA);TET3 (morbid/RE=mTL_miRNA);TG (morbid/RE=mTL_miRNA);TGFB1 (morbid/RE=mTL_miRNA);THRA (morbid/RE=mTL_miRNA);THSD4 (morbid/RE=mTL_miRNA);TIMM8A (HI=3/morbid/RE=mTL_miRNA);TMEM126B (morbid/RE=mTL_miRNA);TMEM127 (HI=3/RE=mTL_miRNA);TMEM63C (morbid/RE=mTL_miRNA);TNPO2 (morbid/RE=mTL_miRNA);TNRC6B (HI=3/morbid/RE=mTL_miRNA);TP53 (HI=3/morbid/RE=mTL_miRNA);TPI1 (morbid/RE=mTL_miRNA);TPM3 (morbid/RE=mTL_miRNA);TRAF7 (morbid/RE=mTL_miRNA);TRDN (morbid/RE=mTL_miRNA);TRIM71 (morbid/RE=mTL_miRNA);TRMT5 (morbid/RE=mTL_miRNA);TRRAP (morbid/RE=mTL_miRNA);TUBA8 (morbid/RE=EA_enhancer+GH_Enhancer+GH_Promoter/Enhancer);TUBB (morbid/RE=mTL_miRNA);TULP1 (morbid/RE=mTL_miRNA);UMPS (morbid/RE=mTL_miRNA);USB1 (morbid/RE=mTL_miRNA);USH1G (morbid/RE=mTL_miRNA);USP18 (morbid/RE=EA_enhancer+GH_Enhancer);VPS51 (morbid/RE=mTL_miRNA);WBP11 (morbid/RE=mTL_miRNA);WBP2 (morbid/RE=mTL_miRNA);WDR45B (morbid/RE=mTL_miRNA);XPC (morbid/RE=mTL_miRNA);XRCC2 (morbid/RE=mTL_miRNA);ZBTB16 (morbid/RE=mTL_miRNA);ZBTB20 (morbid/RE=mTL_miRNA);ZBTB7A (morbid/RE=mTL_miRNA);ZFYVE27 (morbid/RE=mTL_miRNA) 22q11.2 recurrent (DGS/VCFS) region (proximal, A-B) (includes TBX1) TS3:ISCA-37433;dbVar:nssv15121202;dbVar:nssv15132168;dbVar:nssv15132429;dbVar:nssv15132430;dbVar:nssv15132553;dbVar:nssv15132642;nssv15139997;dbVar:nssv15132749;dbVar:nssv15133139;dbVar:nssv15133442;dbVar:nssv15133527;dbVar:nssv15133528;dbVar:nssv15133531;dbVar:nssv15133921;dbVar:nssv15134211;dbVar:nssv15134239;dbVar:nssv15134353;dbVar:nssv15136015;dbVar:nssv15137439;dbVar:nssv15138177;dbVar:nssv15138869;dbVar:nssv15140282;dbVar:nssv15141369;dbVar:nssv15153269;dbVar:nssv15156361;dbVar:nssv15605811;dbVar:nssv15605831;dbVar:nssv15605876;dbVar:nssv15755816;dbVar:nssv16207465;dbVar:nssv16736612;dbVar:nssv16736616 22:18894836-20311784;22:18894836-21461752;22:18894836-21464119;22:18896973-21440514;22:18900756-21075586;22:18908833-21358123;22:18909039-21440514;22:18909045-21464119;22:18912232-20287208;22:18912515-21431174;22:18916828-21050078;22:18916829-20312661;22:18916843-20311858;22:18916843-20312661;22:18919943-20311763;22:18919943-20659606;22:18919943-20708934;22:18919943-21440514;22:18923899-21431174;22:18937381-21459713;22:18938162-21455556;22:18950767-21455556;22:18970562-21040836;22:19168759-20942862;22:20895156-21374512;22:20958985-21379958;22:21044197-21440455;22:21045039-21455556;22:21065883-21440455;22:21081261-21440455;22:21086707-21445960;22:21300291-21331188 22q11.2 recurrent (DGS/VCFS) region (proximal, A-B) (includes TBX1);Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR;Cardiac_arrhythmia|Intellectual_disability|Seizure|Episodic_flaccid_weakness|Acute_rhabdomyolysis|Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome;Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR;Combined D-2- and L-2-hydroxyglutaric aciduria, 615182 (3) AR;Myasthenic syndrome, congenital, 23, presynaptic, 618197 (3) AR;Conotruncal anomaly face syndrome, 217095 (3);DiGeorge syndrome, 188400 (3) AD;Tetralogy of Fallot, 187500 (3) AD;Velocardiofacial syndrome, 192430 (3) AD;DiGeorge_syndrome;Gastrointestinal defects and immunodeficiency syndrome 2, 619708 (3) AR;Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis, 616531 (3) AR;Spastic paraplegia 84, AR, 619621 (3) AR;Hyperprolinemia, type I, 239500 (3) AR;Schizophrenia, susceptibility to, 4, 600850 (3) AD;Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, 616878 (3) AR;Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;Schwannomatosis-2, susceptibility to, 615670 (3) AD;Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD;Van den Ende-Gupta syndrome, 600920 (3) AR HP:0000730;HP:0001249;HP:0001250;HP:0001267;HP:0001275;HP:0001286;HP:0001303;HP:0001656;HP:0001661;HP:0001665;HP:0001666;HP:0001687;HP:0001721;HP:0002122;HP:0002125;HP:0002182;HP:0002192;HP:0002279;HP:0002306;HP:0002316;HP:0002348;HP:0002382;HP:0002386;HP:0002391;HP:0002402;HP:0002417;HP:0002430;HP:0002431;HP:0002432;HP:0002434;HP:0002437;HP:0002458;HP:0002466;HP:0002479;HP:0002482;HP:0002499;HP:0002543;HP:0002794;HP:0003752;HP:0003767;HP:0004351;HP:0005158;HP:0006833;HP:0006997;HP:0007154;HP:0007176;HP:0007180;HP:0008942;HP:0010520;HP:0011675 CLN:226591;CLN:959024;HI3:ISCA-37433;dbVar:nssv15119864;dbVar:nssv15120710;dbVar:nssv15124351;dbVar:nssv15124515;dbVar:nssv15129189;dbVar:nssv15130834;dbVar:nssv15130929;dbVar:nssv15131088;dbVar:nssv15131611;dbVar:nssv15132323;nssv15139981;dbVar:nssv15132334;dbVar:nssv15132747;dbVar:nssv15132748;dbVar:nssv15132933;dbVar:nssv15132934;dbVar:nssv15132935;dbVar:nssv15132939;dbVar:nssv15133099;dbVar:nssv15133185;dbVar:nssv15133186;dbVar:nssv15133443;dbVar:nssv15133817;dbVar:nssv15134350;nssv15139984;dbVar:nssv15134354;dbVar:nssv15134360;dbVar:nssv15134361;dbVar:nssv15134635;dbVar:nssv15134703;dbVar:nssv15134820;dbVar:nssv15134849;dbVar:nssv15136233;dbVar:nssv15137726;dbVar:nssv15137759;dbVar:nssv15137802;dbVar:nssv15138106;dbVar:nssv15138475;dbVar:nssv15139405;dbVar:nssv15139434;dbVar:nssv15139445;nssv15774763;dbVar:nssv15139759;dbVar:nssv15140043;dbVar:nssv15140048;dbVar:nssv15140057;dbVar:nssv15141198;dbVar:nssv15141722;dbVar:nssv15142496;dbVar:nssv15143197;dbVar:nssv15143645;dbVar:nssv15144279;dbVar:nssv15144449;dbVar:nssv15153165;dbVar:nssv15154011;dbVar:nssv15155693;dbVar:nssv15156360;dbVar:nssv15162020;dbVar:nssv15162021;dbVar:nssv15605807;dbVar:nssv15605829;dbVar:nssv15605830;nssv16216546;dbVar:nssv15605834;dbVar:nssv15755310;dbVar:nssv15755712;dbVar:nssv15755812;dbVar:nssv15770037;dbVar:nssv15770783;dbVar:nssv15770877;dbVar:nssv15772938;nssv15773614;nssv15775115;nssv15775184;nssv15775592;dbVar:nssv15772982;dbVar:nssv15775129;dbVar:nssv15776509;dbVar:nssv15776863;dbVar:nssv15776865;dbVar:nssv15776871;dbVar:nssv16208595;dbVar:nssv16208596;dbVar:nssv16212111;dbVar:nssv16213307;dbVar:nssv16213808;dbVar:nssv16214784;dbVar:nssv16215255;dbVar:nssv16215257;dbVar:nssv16216543;dbVar:nssv16216544;nssv8639845;nssv15161831;dbVar:nssv16254574;dbVar:nssv16254739;dbVar:nssv16255831;dbVar:nssv16736634;dbVar:nssv17171460;nssv17974163;dbVar:nssv17171461;dbVar:nssv17171462;dbVar:nssv17171558;dbVar:nssv17171559;dbVar:nssv17171582;dbVar:nssv17171771;dbVar:nssv17171772;dbVar:nssv17649936;dbVar:nssv17649973;dbVar:nssv17955605;dbVar:nssv17955606;dbVar:nssv17955868;dbVar:nssv17970829;dbVar:nssv17971092;dbVar:nssv17971094;dbVar:nssv17971356;dbVar:nssv17971399;dbVar:nssv8639589;nssv15122532;morbid:GP1BB;morbid:LZTR1;morbid:PI4KA;morbid:PRODH;morbid:SCARF2;morbid:SERPIND1;morbid:SLC25A1;morbid:SNAP29;morbid:TANGO2;morbid:TBX1 22:18894836-20238206;22:18894836-20311763;22:18894836-20659606;22:18894836-21440514;22:18894836-21461752;22:18894836-21461811;22:18894836-21464119;22:18896973-20311763;22:18896973-21382953;22:18896973-21440514;22:18899288-18925066;22:18900294-18924066;22:18900295-18923806;22:18900443-21440514;22:18900669-18923820;22:18900669-19747220;22:18900669-19770565;22:18900689-18923800;22:18900689-21351637;22:18900896-18923882;22:18901005-21408430;22:18905110-19015451;22:18910311-18923800;22:18910311-18923820;22:18910311-19770565;22:18912232-20287208;22:18912404-21431174;22:18912871-21431174;22:18915348-21463730;22:18916828-20311858;22:18916829-20312661;22:18916829-21041014;22:18916829-21049800;22:18916843-19004772;22:18916843-20310938;22:18916843-20311858;22:18916843-20312661;22:18916843-20716903;22:18916843-20767095;22:18916843-21011216;22:18916843-21033371;22:18916843-21075592;22:18918742-20311922;22:18919580-21460595;22:18919943-20311763;22:18919943-20659606;22:18919943-20708934;22:18919943-21025713;22:18919943-21440514;22:18922152-21449911;22:18938162-20229017;22:18938162-20996250;22:18938162-21455556;22:18962314-21455556;22:18999804-21455499;22:18999804-21455556;22:19016664-21463730;22:19023802-21440455;22:19023802-21440514;22:19035018-21461811;22:19035324-21464119;22:19036287-21208284;22:19058830-21440514;22:19156118-19529130;22:19163094-19166249;22:19163624-19770565;22:19470352-19481849;22:19709401-21142058;22:19709436-19712313;22:19709952-19963280;22:19710419-21142058;22:19711062-19712294;22:19743227-19755855;22:19743425-19747210;22:19743425-19754400;22:19743425-19770565;22:19743474-19747220;22:19747168-19754390;22:19748301-19754857;22:19748451-19748647;22:20008633-20054687;22:20027161-20063237;22:20028564-20053554;22:20028993-20062955;22:20029136-20062954;22:20029701-20062756;22:20030823-20041691;22:20030823-20053554;22:20030859-20052185;22:20030879-20049206;22:20030879-20052185;22:20036383-20045782;22:20036384-20045781;22:20036385-20045784;22:20052066-20052185;22:20708891-21407690;22:20718171-21427936;22:20733496-21463730;22:20745763-21460658;22:20754408-21440515;22:20754408-21457610;22:20754423-21461752;22:20778874-20792112;22:20921343-21459713;22:21061979-21213100;22:21062169-21463730;22:21062567-21463730;22:21065883-21455556;22:21067570-21414817;22:21069074-21463730;22:21074921-21440514;22:21075576-21454721;22:21081285-21457610;22:21128401-21142008;22:21213295-21245501;22:21335907-21346541;22:21336586-21353320;22:21336662-21337398;22:21336662-21351637 CLN:1349334;dbVar:nssv17974796 22:21337344-21337343;22:21337344-21337456 22q11.2 recurrent (DGS/VCFS) region (proximal, A-D) (includes TBX1) dbVar:nssv15161990;dbVar:nssv15139753;dbVar:nssv15150031;dbVar:nssv15150491;dbVar:nssv15146973;dbVar:nssv15135173;dbVar:nssv15137211;dbVar:nssv15129128;dbVar:nssv15161991;dbVar:nssv15161992;dbVar:nssv15164031;dbVar:nssv16254742;dbVar:nssv16297047;dbVar:nssv15151140;nssv16207460;dbVar:nssv15141953;dbVar:nssv15156366;nssv15772157;dbVar:nssv16207463;dbVar:nssv16296938;dbVar:nssv16207464;dbVar:nssv15774756;dbVar:nssv15149512;nssv15150794;dbVar:nssv15139758;dbVar:nssv15755803;dbVar:nssv15774287;dbVar:nssv15605979;dbVar:nssv15139756;dbVar:nssv15605980;dbVar:nssv15137771;dbVar:nssv15132295;dbVar:nssv15133039;dbVar:nssv15133301;dbVar:nssv15132518;dbVar:nssv15134365;dbVar:nssv15146613;dbVar:nssv15133111;dbVar:nssv15147269;dbVar:nssv15121201;dbVar:nssv15136264;dbVar:nssv15605803;dbVar:nssv15605804;dbVar:nssv16736606;dbVar:nssv15128891;dbVar:nssv15126571;dbVar:nssv15128500;dbVar:nssv16254735;dbVar:nssv15140068;dbVar:nssv15137505;dbVar:nssv15128758;dbVar:nssv15152138;dbVar:nssv15154014;dbVar:nssv15755815;dbVar:nssv15755817;dbVar:nssv16255668;dbVar:nssv15156359;dbVar:nssv15142823;dbVar:nssv15140066;dbVar:nssv15133432;dbVar:nssv15605805;dbVar:nssv15605808;dbVar:nssv15605806;dbVar:nssv15132858;dbVar:nssv15133520;dbVar:nssv15132127;dbVar:nssv15133128;dbVar:nssv15136566;dbVar:nssv15133389;dbVar:nssv15140044;dbVar:nssv15133925;dbVar:nssv15138146;dbVar:nssv15133393;nssv15139545;dbVar:nssv15135020;dbVar:nssv15132566;dbVar:nssv15164039;dbVar:nssv17955656;dbVar:nssv15132423;dbVar:nssv15132330;dbVar:nssv15126758;dbVar:nssv15127771;dbVar:nssv15126436;dbVar:nssv17649918;dbVar:nssv15162011;dbVar:nssv15125959;dbVar:nssv17955842;dbVar:nssv15139556;dbVar:nssv15122631;dbVar:nssv15123767;dbVar:nssv15162014;dbVar:nssv15143627;dbVar:nssv16865904;dbVar:nssv15123759;dbVar:nssv17650003;dbVar:nssv15755805;dbVar:nssv15132167;dbVar:nssv15133526;dbVar:nssv15162019;dbVar:nssv15145463;dbVar:nssv15145234;dbVar:nssv16207634;dbVar:nssv15605810;dbVar:nssv15605809;dbVar:nssv15139749;dbVar:nssv15140369;dbVar:nssv15136643;dbVar:nssv15131931;nssv15133075;dbVar:nssv15131925;dbVar:nssv15134715;dbVar:nssv15132426;TS3:ISCA-37446;dbVar:nssv15605828;dbVar:nssv15153271;dbVar:nssv15139887;dbVar:nssv15137698;dbVar:nssv15139242;dbVar:nssv15132247;nssv15139527;dbVar:nssv15131997;nssv15139348;dbVar:nssv15137835;dbVar:nssv15132026;nssv15139977;dbVar:nssv15127741;dbVar:nssv15154013;dbVar:nssv16254573;dbVar:nssv16255670;dbVar:nssv15133914;dbVar:nssv15145464;dbVar:nssv15755306;dbVar:nssv15132169;dbVar:nssv16207466;dbVar:nssv15132044;dbVar:nssv15139694;dbVar:nssv15120579;dbVar:nssv15133646;dbVar:nssv15139596;dbVar:nssv15132083;dbVar:nssv15139716;dbVar:nssv15135998;dbVar:nssv15139748 22:16054668-51243435;22:16054692-27296513;22:16054692-51220902;22:16054692-51237463;22:16054692-51237518;22:16087695-19010508;22:16087695-20311784;22:16114245-18917748;22:16114245-20737903;22:16114245-51195728;22:16114245-51211392;22:16197006-51224252;22:16800001-21500000;22:16888900-18916828;22:16888900-20311858;22:16888900-20312661;22:16888900-22290476;22:16888900-26483608;22:16888900-27657507;22:16888900-51197838;22:16888901-51197838;22:17012936-21431054;22:17041670-20247250;22:17055734-20312661;22:17072087-20130474;22:17264512-23238029;22:17289828-20311922;22:17397499-18984519;22:17397499-20311763;22:17397499-20659606;22:17397499-20708934;22:17397499-21505417;22:17397499-24754904;22:17397499-51178264;22:17397634-19584890;22:17397634-51178213;22:18533255-18942804;22:18570313-19184416;22:18609713-21408430;22:18611224-21408430;22:18628020-20311763;22:18628133-21712996;22:18628133-21900562;22:18628133-51244566;22:18628148-21722313;22:18637140-20289862;22:18640730-21465659;22:18641480-21917191;22:18644791-21465659;22:18645354-21465659;22:18648856-21461017;22:18648856-21927646;22:18648867-21465659;22:18649190-20311858;22:18650665-21440455;22:18650665-21440514;22:18650676-21455556;22:18650746-21460220;22:18650804-21386010;22:18650804-21460220;22:18651615-21440455;22:18652638-21914178;22:18660554-21455556;22:18661700-21505445;22:18661700-22905025;22:18661725-20311763;22:18661725-21025713;22:18661725-21440514;22:18661725-21461752;22:18661725-21505417;22:18661725-21661435;22:18661725-32217179;22:18675474-21465050;22:18687211-19060954;22:18704555-21411284;22:18706002-21440514;22:18713492-20412989;22:18713492-21712996;22:18713492-21917191;22:18841375-21465101;22:18844633-21463730;22:18848021-21468378;22:18873002-21469900;22:18874966-21028946;22:18877788-20306993;22:18877788-21462353;22:18878410-21467387;22:18886916-20278471;22:18886916-21461017;22:18886916-23421058;22:18889978-21463189;22:18890265-21464056;22:18890272-21505417;22:18890272-21561514;22:18891399-21463730;22:18891967-20311852;22:18891967-21631412;22:18892576-20306993;22:18892576-20308800;22:18892576-21460220;22:18894340-21032422;22:18894340-21440455;22:18894821-21505445;22:18894836-21505417;22:18894836-21561514;22:18894836-21809009;22:18909039-21798755;22:18912232-21465672;22:18912515-21922035;22:18916828-21465659;22:18916829-21465659;22:18916829-21465662;22:18916843-21465659;22:18919943-21505417;22:18919943-21561514;22:18919943-21801604;22:18919943-21809009;22:18919988-21561468;22:18970561-21465662;22:19024657-21465662;22:19035090-22672555;22:19058830-21561514;22:19346606-21864619;22:19819478-21464764;22:20402634-21561514;22:20732809-25193541;22:20748977-21499971;22:20754423-21505417;22:21022841-22712836;22:21025655-21505417;22:21025655-22336268;22:21025655-22400806;22:21081261-21505417;22:21261515-37583387;22:21400684-23654222 7.30;22.85;7.31;7.30;7.30;3.96;33.54;0.82;39.86;7.32;7.32;7.34;54.67;1.08;41.40;41.41;47.57;26.78;23.86;7.49;7.49;57.40;42.19;43.53;40.40;43.01;46.89;5.65;48.62;54.10;54.78;62.54;34.92;7.61;31.55;7.61;11.71;47.16;89.81;89.86;84.15;83.29;78.51;7.88;83.04;84.41;90.95;78.43;91.08;91.10;91.25;78.36;91.21;85.23;91.25;91.25;91.30;91.31;91.08;91.31;91.28;78.78;91.62;90.35;60.55;85.87;90.14;91.61;91.67;90.35;85.65;18.95;92.10;44.45;92.97;93.09;89.33;85.66;80.20;97.92;98.08;98.05;98.94;99.08;98.81;99.34;99.24;99.43;99.69;56.67;99.81;99.82;98.25;96.18;99.87;99.80;93.79;99.84;99.84;99.91;99.98;99.98;98.42;98.42;96.35;88.17;88.42;99.94;84.78;99.94;99.94;99.94;99.94;98.40;96.31;88.29;88.06;96.31;99.94;99.94;66.78;96.11;84.09;99.96;91.60;16.39;95.23;94.50;26.11;91.39;33.45;31.88;90.26;1.24;2.81 22q11.2 recurrent (DGS/VCFS) region (proximal, A-D) (includes TBX1) dbVar:nssv15134634;dbVar:nssv16208592;dbVar:nssv16208593;dbVar:nssv15141423;dbVar:nssv15132388;dbVar:nssv15128094;dbVar:nssv15132068;dbVar:nssv15133055;dbVar:nssv16207650;dbVar:nssv15153272;dbVar:nssv15135754;dbVar:nssv15133431;nssv15139986;dbVar:nssv15125556;dbVar:nssv15126775;dbVar:nssv15133864;dbVar:nssv15755811;dbVar:nssv15755813;dbVar:nssv15126915;dbVar:nssv15128185;dbVar:nssv15145459;dbVar:nssv15145460;dbVar:nssv15138286;dbVar:nssv15154015;dbVar:nssv15153273;dbVar:nssv15145461;dbVar:nssv15138328;dbVar:nssv15154017;dbVar:nssv15140316;dbVar:nssv15133433;dbVar:nssv17955872;dbVar:nssv15133434;dbVar:nssv16255835;dbVar:nssv15132708;dbVar:nssv15134184;dbVar:nssv15132128;nssv15139349;dbVar:nssv15134982;dbVar:nssv15135883;dbVar:nssv15133394;nssv16091745;dbVar:nssv15132006;nssv15139990;dbVar:nssv15137884;dbVar:nssv15133435;dbVar:nssv15135454;dbVar:nssv15133438;nssv15140028;dbVar:nssv15132230;nssv15139684;dbVar:nssv15132655;nssv15139976;dbVar:nssv15136079;dbVar:nssv15132507;nssv15139975;dbVar:nssv15132389;dbVar:nssv17976452;dbVar:nssv15164040;dbVar:nssv15137872;dbVar:nssv16254738;dbVar:nssv15127636;dbVar:nssv15128166;dbVar:nssv15127784;dbVar:nssv16208773;dbVar:nssv15145231;dbVar:nssv15145040;dbVar:nssv15145232;dbVar:nssv15139558;dbVar:nssv15163611;dbVar:nssv16215256;dbVar:nssv15128065;dbVar:nssv17955534;dbVar:nssv15163612;dbVar:nssv15145462;dbVar:nssv15145233;dbVar:nssv15163613;dbVar:nssv15132390;dbVar:nssv15163614;dbVar:nssv15162012;dbVar:nssv15139255;dbVar:nssv15162013;dbVar:nssv15162015;dbVar:nssv17976449;dbVar:nssv17955549;dbVar:nssv15162016;nssv16215222;nssv16215239;nssv16865884;dbVar:nssv15162017;dbVar:nssv15164042;dbVar:nssv15143222;dbVar:nssv15162018;dbVar:nssv16865881;dbVar:nssv15164043;dbVar:nssv15755824;dbVar:nssv17650004;dbVar:nssv17649858;dbVar:nssv16297048;dbVar:nssv17517456;dbVar:nssv15141730;dbVar:nssv15126093;dbVar:nssv15125439;dbVar:nssv15755804;dbVar:nssv15121171;dbVar:nssv15133439;dbVar:nssv15132392;dbVar:nssv15132132;dbVar:nssv15133440;dbVar:nssv15136213;dbVar:nssv15605874;nssv15605879;dbVar:nssv15119655;dbVar:nssv17173212;dbVar:nssv17173202;dbVar:nssv16091922;dbVar:nssv15143862;dbVar:nssv15140698;dbVar:nssv15139562;dbVar:nssv15140747;dbVar:nssv15140051;dbVar:nssv15133317;nssv15143213;dbVar:nssv15131926;dbVar:nssv15605919;dbVar:nssv15755810;HI3:ISCA-37446;dbVar:nssv15139269;dbVar:nssv15137499;dbVar:nssv15138712;dbVar:nssv15139855;dbVar:nssv15139854;nssv15153270;dbVar:nssv15154016;dbVar:nssv15152149;dbVar:nssv15137491;dbVar:nssv15141653;dbVar:nssv15142207;dbVar:nssv15755814;dbVar:nssv15132248;nssv15139690;dbVar:nssv15134351;dbVar:nssv15132463;nssv15139699;dbVar:nssv15132523;dbVar:nssv15155695;dbVar:nssv17976290;nssv17976296;dbVar:nssv17976279;dbVar:nssv15139289;dbVar:nssv15139467;dbVar:nssv15142401;dbVar:nssv15134356;dbVar:nssv15137446;dbVar:nssv15153268;dbVar:nssv15156357;dbVar:nssv15132608;dbVar:nssv15145465;dbVar:nssv15145466;dbVar:nssv15145235;dbVar:nssv15772502;dbVar:nssv15154008;dbVar:nssv15156354;dbVar:nssv15755308;nssv15755309;dbVar:nssv15155696;dbVar:nssv17956682;dbVar:nssv15776637;dbVar:nssv17649919;dbVar:nssv15120712;dbVar:nssv15139564;dbVar:nssv16208598;dbVar:nssv15755307;dbVar:nssv15156347;dbVar:nssv15755311;dbVar:nssv17957425;dbVar:nssv15121593;dbVar:nssv15154007;dbVar:nssv15134856 22:16087695-19363465;22:16888900-20125005;22:16888900-20730144;22:16888901-20026751;22:17019016-20718227;22:17177912-19892632;22:17397499-20311763;22:17397499-20708934;22:18475386-23764120;22:18626109-21800797;22:18628020-21464119;22:18628020-21505417;22:18628133-21561468;22:18628133-21883879;22:18628148-21440515;22:18631365-21800471;22:18636750-21800471;22:18641480-21712996;22:18641480-21722262;22:18642647-21717111;22:18642647-21742277;22:18644242-21465662;22:18644543-21465659;22:18644791-21915509;22:18646694-21631412;22:18648857-21465662;22:18648867-21800797;22:18650665-21440455;22:18650676-21455556;22:18660136-21737597;22:18660554-21455556;22:18661700-21457610;22:18661700-21505445;22:18661725-20659606;22:18661725-21440514;22:18661725-21461811;22:18661725-21464119;22:18661725-21505417;22:18661725-21561514;22:18661725-21809009;22:18671630-21536841;22:18706002-20311763;22:18706002-20659606;22:18706002-21025713;22:18706002-21440514;22:18706002-21464119;22:18706002-21505417;22:18706002-21809009;22:18718029-21326012;22:18728119-21811991;22:18765086-21661435;22:18765103-21661435;22:18788000-21065894;22:18788000-21468378;22:18788000-21684798;22:18789966-21591197;22:18790223-21697998;22:18820423-21477877;22:18834453-21575702;22:18844633-21463730;22:18844633-21608479;22:18844633-21797812;22:18848021-21468378;22:18861210-21630630;22:18861749-21463730;22:18868433-20331055;22:18868433-21477877;22:18872509-21465050;22:18874457-20306317;22:18875870-21470273;22:18875957-21466715;22:18876631-21465659;22:18878410-21465050;22:18878410-21907671;22:18884515-21484289;22:18884715-21483289;22:18886916-21463730;22:18886916-21465050;22:18886916-21467387;22:18886916-21811991;22:18889491-20312668;22:18889491-21463730;22:18889491-21466715;22:18889491-21917190;22:18889572-21464697;22:18889694-21465485;22:18889951-21466053;22:18889970-21462658;22:18890043-21440455;22:18890163-21464056;22:18890222-21561468;22:18890265-21540347;22:18890272-18999862;22:18890272-20328113;22:18890272-20659606;22:18890272-21394730;22:18890272-21461811;22:18891527-21796215;22:18892576-21460220;22:18893736-18924066;22:18893883-21563420;22:18893883-21571027;22:18893888-18923800;22:18893889-18973671;22:18894340-20255110;22:18894340-20255154;22:18894340-21440455;22:18894340-21440514;22:18894836-21505417;22:18894836-21561514;22:18900756-21800277;22:18912232-21465672;22:18912232-21465672;22:18916828-21465662;22:18916829-21465659;22:18916829-21465662;22:18916843-21465659;22:18916843-21465662;22:18916843-21798907;22:18916843-21804716;22:18916843-21804886;22:18917048-21465659;22:18917048-21465662;22:18919478-21800471;22:18919943-21505417;22:18919943-21505558;22:18919943-21561514;22:18919943-21809009;22:18935464-21465659;22:18936190-21464809;22:18936191-21464809;22:18970562-21465662;22:19024657-21465659;22:19024658-21465662;22:19029603-21505417;22:20279767-23822986;22:20311904-21465659;22:20311904-21800797;22:20659548-21561514;22:20703817-21503296;22:20703817-21631412;22:20713276-21477877;22:20716877-21465659;22:20716877-21465662;22:20716877-21798907;22:20716877-21800471;22:20716877-23819697;22:20728958-21915096;22:20729389-21465662;22:20730997-21465342;22:20733428-21505417;22:20749626-23972878;22:21029656-22481498;22:21033587-21800471;22:21049800-21465662;22:21059670-21800471;22:21059670-21804716;22:21065883-21937680;22:21075676-21465662;22:21081261-24593820 14.31;38.01;47.78;36.07;49.29;36.76;48.62;54.78;48.58;80.93;90.59;89.29;87.59;78.92;90.52;81.07;81.21;83.65;83.40;83.57;82.89;91.06;91.07;78.55;86.08;91.21;81.51;91.25;91.30;83.49;91.62;91.66;90.35;88.33;91.61;91.67;91.68;90.35;88.60;81.63;89.67;88.24;90.33;91.86;93.09;93.15;91.78;82.80;93.22;83.31;88.71;88.71;95.31;95.86;88.69;91.72;88.36;96.68;93.73;98.08;92.96;87.00;98.05;92.77;98.73;98.19;98.46;99.10;98.58;99.03;99.17;99.24;99.33;84.82;98.83;98.87;99.69;99.66;99.57;87.84;99.62;99.79;99.69;84.86;99.77;99.75;99.74;99.81;99.81;99.82;96.18;96.95;95.84;99.68;99.74;99.82;99.82;88.45;99.91;96.37;96.24;95.97;96.83;98.81;99.96;99.96;99.98;99.98;98.42;96.35;88.41;99.94;99.94;99.94;99.94;99.94;99.94;99.94;88.38;88.21;88.20;99.94;99.94;88.33;98.40;98.40;96.31;88.06;99.94;99.97;99.97;99.94;99.94;99.94;98.33;33.43;99.87;77.39;89.20;95.10;81.96;98.20;99.79;99.79;69.06;68.96;24.08;61.98;99.79;99.83;94.65;22.17;29.92;56.14;99.63;54.60;54.29;45.68;99.60;10.90 159 2-hydroxyglutaric_aciduria;Abnormality_of_metabolism/homeostasis;Acute_rhabdomyolysis;Autism_spectrum_disorder;Bernard_Soulier_syndrome;CEDNIK_syndrome;Cardiac_arrhythmia;D,L-2-hydroxyglutaric_aciduria;DiGeorge_syndrome;Episodic_flaccid_weakness;Fetal_cystic_hygroma;Hypomyelinating_leukodystrophy_2;Inborn_genetic_diseases;Intellectual_disability;Macrothrombocytopenia;Meier-Gorlin_syndrome_7;Metabolic_crises_with_rhabdomyolysis,_cardiac_arrhythmias,_and_neurodegeneration;Myasthenic_syndrome,_congenital,_23,_presynaptic;Noonan_syndrome_10;Noonan_syndrome_2;Noonan_syndrome_and_Noonan-related_syndrome;Polymicrogyria,_perisylvian,_with_cerebellar_hypoplasia_and_arthrogryposis;Proline_dehydrogenase_deficiency;RASopathy;Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome;Schwannomatosis;Schwannomatosis_2;See_cases;Seizure;Short_stature;Thrombocytopenia;Van_den_Ende-Gupta_syndrome 22:18911000-18917000 gnomAD-SV_v2.1_DUP_22_50649;22:19158000-19164000 gnomAD-SV_v2.1_DUP_22_50680;22:19238714-19238714 1000g;22:19435958-19435958 1000g;22:19732500-19738000 gnomAD-SV_v2.1_DUP_22_50708;22:19906886-19906886 1000g;22:19961500-19966500 gnomAD-SV_v2.1_DUP_22_50737;22:20213164-20213251 gnomAD-SV_v2.1_DUP_22_50767;22:20483000-20490000 gnomAD-SV_v2.1_DUP_22_50783;22:20697800-20704000 gnomAD-SV_v2.1_DUP_22_50788;22:20721912-20722063 CMRI:73_pbsv.INS.DUP.179;22:21044000-21050400 gnomAD-SV_v2.1_DUP_22_50821;22:21366000-21371000 gnomAD-SV_v2.1_DUP_22_50848;22:18912158-18998999 1000g;22:18924000-18940000 gnomAD-SV_v2.1_DUP_22_50652;22:19717000-19731000 gnomAD-SV_v2.1_DUP_22_50707;22:20247000-20252000 gnomAD-SV_v2.1_DUP_22_50772;22:20333000-20381150 gnomAD-SV_v2.1_DUP_22_50780;22:20451000-20466000 gnomAD-SV_v2.1_DUP_22_50781;22:20660699-20704000 gnomAD-SV_v2.1_DUP_22_50785;22:21033800-21039000 gnomAD-SV_v2.1_DUP_22_50819... 22:18897000-18902500 gnomAD-SV_v2.1_DUP_22_50648;22:19148049-19148136 gnomAD-SV_v2.1_DUP_22_50677;22:19210914-19210914 1000g;22:19361569-19361569 1000g;22:19702276-19702320 DDD:56203;22:19736000-19741000 gnomAD-SV_v2.1_DUP_22_50709;22:19907252-19907315 gnomAD-SV_v2.1_DUP_22_50731;22:20067805-20068161 DDD:56218;22:20472000-20477100 gnomAD-SV_v2.1_DUP_22_50782;22:20693000-20704000 gnomAD-SV_v2.1_DUP_22_50787;22:20710000-20715500 gnomAD-SV_v2.1_DUP_22_50790;22:20756042-20756172 gnomAD-SV_v2.1_DUP_22_50798;22:21088868-21089010 DDD:56283;22:18884850-18926400 gnomAD-SV_v2.1_DUP_22_50647;22:18912158-18998999 esv3647250;22:19693500-19700500 gnomAD-SV_v2.1_DUP_22_50703;22:20017400-20023000 gnomAD-SV_v2.1_DUP_22_50746;22:20295000-20301500 gnomAD-SV_v2.1_DUP_22_50776;22:20343574-20380608 DDD:56234;22:20609431-20628300 gnomAD-SV_v2.1_DUP_22_50784;22:20930000-20939100 gnomAD-SV_v2.1_DUP_22_50808... 22:18929400-18935100 gnomAD-SV_v2.1_DEL_22_181327;22:18977576-18977640 1000g;22:18977576-18977640 CMRI:0_pbsv.DEL.107_duplicate7;22:19063767-19063900 gnomAD-SV_v2.1_DEL_22_181349;22:19099907-19100607 1000g;22:19099931-19100625 DDD:56189;22:19099932-19100625 gnomAD-SV_v2.1_DEL_22_181355;22:19123753-19123831 CMRI:0_pbsv.DEL.110_duplicate8;22:19173111-19174390 DDD:56191;22:19247916-19248102 1000g;22:19558060-19558176 CMRI:4_pbsv.DEL.177_duplicate8;22:19568989-19573159 esv3568252;22:19571619-19573101 esv2677704;22:19571625-19573094 1000g;22:19571619-19573101 CMRI:0_pbsv.DEL.117_duplicate11;22:19684354-19684415 CMRI:0_pbsv.DEL.121_duplicate7;22:19713412-19713471 CMRI:60_pbsv.DEL.113_duplicate9;22:19818958-19819595 DDD:56208;22:19912531-19913412 DDD:56212;22:19912545-19913442 esv3647282;22:19947323-19947389 CMRI:1_pbsv.DEL.134_duplicate9... 22:18927000-18935050 gnomAD-SV_v2.1_DEL_22_181326;22:18949221-18949273 CMRI:266_pbsv.DEL.193_duplicate9;22:18977576-18977640 gnomAD-SV_v2.1_DEL_22_181334;22:19050321-19050378 CMRI:35_pbsv.DEL.171_duplicate10;22:19098616-19100995 dgv1286e212;22:19099907-19100607 esv3647259;22:19099931-19100625 esv2678705;22:19099931-19100625 CMRI:2_pbsv.DEL.206_duplicate10;22:19155935-19155991 CMRI:0_pbsv.DEL.112_duplicate6;22:19247798-19248102 gnomAD-SV_v2.1_DEL_22_181371;22:19538797-19538876 CMRI:0_pbsv.DEL.115_duplicate11;22:19558190-19558253 CMRI:0_pbsv.DEL.116_duplicate12;22:19571619-19573101 DDD:56198;22:19571619-19573101 gnomAD-SV_v2.1_DEL_22_181389;22:19571625-19573094 esv3647277;22:19684792-19689697 dgv1287e212;22:19702276-19702320 DDD:56203;22:19781824-19783505 dgv1288e212;22:19912525-19913406 gnomAD-SV_v2.1_DEL_22_181419;22:19912545-19913442 1000g;22:19912531-19913412 CMRI:13_pbsv.DEL.181_duplicate11... 1001302;1001303;1001304;1001305;1001306;1001839;1004358;1004359;1004360;1004361;1004362;1004363;1007574;1008232;1008233;1008234;1008235;1008390;1008392;1008397;1008404;1008412;1008416;1008428;1008433;1008748;1009921;1009922;1009923;1009924;1009925;1010990;1011193;1011198;1011201;1011203;1011827;1012827;1013568;1013569;1013570;1013571;1013572;101360;101361;101362;101363;101364;1013932;1019076;1019522;... gain;loss 0.445 0.320 22:18894850-18894969 L1ME2z 22:21464126-21464591 L1MA7 22:18889511-18912230 2 97.89 -0.807902299547855 -1.20830830104818 -0.791505674827999 2.94244265911253 5.29477062168781 603465;116790;601362;138720;600574;600286;606810;605566;613619;142360;190315;604202;616830;602054;606448 yes yes 0 1.0000e+00 1.0000e+00 1.9 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3C (77 genes, +0.90);5F (+0.00) 5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 AIFM3 NM_144704 21319459 21335647 16188 1818 100 no 21 txStart-txEnd 5'UTR-3'UTR 21319459 21335647 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 38.59 -1.14442881641699 -1.26664892202732 -0.922844550293754 0.687283106386744 1.33036583543754 5 1.9474e-14 1.9583e-10 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ARVCF NM_001670 19957418 20004346 46928 2889 100 no 20 txStart-txEnd 5'UTR-3'UTR 19957418 20004346 20575;263488;35010;35386;393084;393085;44709;498907;847960;871048 gain;loss 54.56 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.425870777992255 -0.701931719398633 4 5.0422e-11 8.2184e-07 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 BCRP2 NR_037566 21457304 21476575 6815 0 0 no 6 txStart-intron1 UTR 6098 3' 21457304 21464119 CMRI:8_pbsv.SPLIT.DUP.222;esv2760719 22:21383283-21845355;22:21107405-21917116 0.1374 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 C22orf39 NM_173793 19428409 19435234 6825 318 100 no 3 txStart-txEnd 5'UTR-3'UTR 19428409 19435234 70.45 -2.53806827104914 -2.53125239294469 -2.47162789907313 0.128056348383697 0.836381939603491 9 1.9976e-05 3.6900e-07 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CCDC188 NM_001365892 20135938 20138578 2640 1209 100 no 9 txStart-txEnd 5'UTR-3'UTR 20135938 20138578 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CDC45 NM_001178010 19467348 19508135 40787 1797 100 no 20 txStart-txEnd 5'UTR-3'UTR 19467348 19508135 dbVar:nssv15124515 22:19470352-19481849 3 Meier-Gorlin_syndrome_7 724957;768153 loss 8.4 -2.57292784443109 -2.53125239294469 -2.47162789907313 0.554183575869215 1.2901097836858 Meier-Gorlin syndrome;Meier-Gorlin syndrome 7 AD;AR Strong;Supportive 11416137;27374770;27374770[PMID];30986546 603465 Meier-Gorlin syndrome 7, 617063 (3) AR AR 3 4.6237e-05 6.9104e-02 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CLDN5 NM_001130861 19510546 19512860 2314 912 52 no 1 txStart-txEnd 5'UTR-3'UTR 19510546 19512860 50.93 2.94244265911253 3.34022892264706 1 8.9512e-01 7.4052e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CLTCL1 NM_007098 19166985 19279242 112257 4923 100 no 33 txStart-txEnd 5'UTR-3'UTR 19166985 19279242 22726;546696;724952;768149 loss 72.86 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.597972033048653 -1.19469008098196 congenital insensitivity to pain with severe intellectual disability;multiple congenital anomalies/dysmorphic syndrome AD;AR Limited;Supportive 26068709[PMID] 5 2.5101e-37 1.2408e-26 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 COMT NM_000754 19929294 19957498 28204 816 100 no 6 txStart-txEnd 5'UTR-3'UTR 19929294 19957498 1059497;1060872;1060985;1061244;1064577;1065708;1067754;1067989;1069000;1070037;1070098;1070187;1070348;1070821;1071230;1071315;1074085;1074180;257442;290501 gain;loss 40.8 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.465852147917107 0.557839148920189 paroxysmal dyskinesia AD Moderate 116790 (Panic disorder, susceptibility to), 167870 (3) ?AD;(Schizophrenia, susceptibility to), 181500 (3) AD ?AD;AD yes 8 1.1377e-06 8.4666e-04 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CRKL NM_005207 21271694 21308035 36341 912 100 no 3 txStart-txEnd 5'UTR-3'UTR 21271694 21308035 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 325941;687520 gain 1 0 4.35 -0.928255048107525 -1.20830830104818 -0.791505674827999 0.477351976371369 3.00980268645085 3 4.4604e-01 1.6345e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR11 NR_024157 19033674 19035888 2214 0 0 no 1 txStart-txEnd UTR 19033674 19035888 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR2 NM_005137 19023798 19109925 86127 1653 100 no 10 txStart-txEnd 5'UTR-3'UTR 19023798 19109925 122920;205629;2058016;2381098;724948;742665;742666;768143;768144;768145;768146 gain;loss 39.12 -0.375038933750903 0.817637812863819 schizophrenia AD Limited 601362 DiGeorge syndrome/velocardiofacial syndrome complex-2, 601362 (2) 4 5.1573e-06 1.0959e-03 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR5 NR_110533 18958010 19018755 60745 0 0 no 6 txStart-txEnd UTR 18958010 19018755 dgv543n27 22:18877788-19033532 0.0100 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR6 NM_005675 18893832 18899601 4766 392 59 yes 5 intron2-txEnd CDS-3'UTR 597 5' 18894835 18899601 DDD:56146;DDD:56173;DDD:56174;dgv543n27;dgv99e203;gnomAD-SV_v2.1_DUP_22_50647 22:18884850-18926400;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;22:18655861-19006984;22:18667571-18994853 0.0355 61.1 -0.678746019468492 -0.22775445384527 9 9.8176e-12 7.6210e-07 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR6L NM_033257 20301760 20307583 5823 663 100 no 5 txStart-txEnd 5'UTR-3'UTR 20301760 20307583 79.33 0.698499439551705 0.174075190759776 7 5.0636e-05 1.2857e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR8 NM_022720 20067763 20099395 31632 2322 100 no 14 txStart-txEnd 5'UTR-3'UTR 20067763 20099395 768159 loss 5.07 -2.46581011772843 -2.53125239294469 -2.47162789907313 0.690563071344625 4.03153091509844 0 9.9973e-01 9.9990e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ESS2 NM_022719 19117791 19132164 14373 1431 100 no 10 txStart-txEnd 5'UTR-3'UTR 19117791 19132164 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM230A NR_165629 20326419 20350461 24042 0 0 no 12 txStart-txEnd UTR 20326419 20350461 DDD:56225;DDD:56226 22:20313251-20369884;22:20322450-20718598 0.0509 DDD:56225;DDD:56226 22:20313251-20369884;22:20322450-20718598 0.0959 97.89 7 4.8065e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM230G NR_165637 20325552 20706786 381234 0 0 no 7 txStart-txEnd UTR 20325552 20706786 DDD:56226 22:20322450-20718598 0.0509 DDD:56226 22:20322450-20718598 0.0118 604023;604024;604025;606062;606699;606700;647582;647584;654218;662044;664070;666971;672397;674122;687514;688039;694221;697104;701385;703550;724976;755035;768170;778682;780112;792637;794104;810727;816744;819867;820657;843179;844942;845721;863579;863580;867045;867213;869166;874040;882061;882062;890080;894603;896115;898364;901195;902552;904184;921206;921731;... gain;loss full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM230J NR_136569 20632119 20656858 24739 0 0 no 9 txStart-txEnd UTR 20632119 20656858 DDD:56226 22:20322450-20718598 0.0509 DDD:56226 22:20322450-20718598 0.0118 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GGTLC3 NM_001355479 20366210 20368028 1818 678 100 no 6 txStart-txEnd 5'UTR-3'UTR 20366210 20368028 DDD:56225;DDD:56226;DDD:56232;DDD:56234;gnomAD-SV_v2.1_DUP_22_50780 22:20333000-20381150;22:20343574-20380608;22:20313251-20369884;22:20322450-20718598;22:20330330-20450295 0.0620 DDD:56225;DDD:56226;DDD:56232;DDD:56234 22:20343574-20380608;22:20313251-20369884;22:20322450-20718598;22:20330330-20450295 0.0959 94.16 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GNB1L NM_053004 19770745 19842397 71652 984 100 no 8 txStart-txEnd 5'UTR-3'UTR 19770745 19842397 344529;724966;950816;951023;951040;951043 gain;loss 48.57 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.373621593221624 0.590344002361273 5 4.7419e-05 1.2635e-03 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GP1BB NM_000407 19711061 19712294 1233 621 100 no 2 txStart-txEnd 5'UTR-3'UTR 19711061 19712294 Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR morbid:GP1BB 22:19711062-19712294 4 Bernard_Soulier_syndrome;Macrothrombocytopenia;Thrombocytopenia 30 78.01 -0.00224146961144303 0.855158778511627 Bernard-Soulier syndrome;autosomal dominant macrothrombocytopenia AD;AR Definitive;Supportive 22886561[PMID];28064200[PMID] 138720 Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR AR yes 7 5.1249e-01 1.0112e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GSC2 NM_005315 19134505 19137805 3300 618 100 no 3 txStart-txEnd 5'UTR-3'UTR 19134505 19137805 65.74 1.18735715980007 0.932740471460801 9 4.4347e-03 3.7186e-02 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 HIRA NM_003325 19318220 19419256 101036 3054 100 no 25 txStart-txEnd 5'UTR-3'UTR 19318220 19419256 520035;521179;724953 loss 0 0 19.48 -2.51547904504873 -2.53125239294469 -2.47162789907313 -0.543665561522748 3.98018572942351 0 1.0000e+00 1.0000e+00 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 KLHL22 NM_032775 20795805 20850082 54277 1905 100 no 7 txStart-txEnd 5'UTR-3'UTR 20795805 20850082 568169;724981;724982;724983;724984;724985;724986;724987 gain;loss 41.2 -1.60479766897668 -1.94085802577819 -1.599983320827 -0.00460568166698648 2.85964800561254 2 4.2419e-01 7.0261e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC00895 NR_024381 19553652 19554362 710 0 0 no 1 txStart-txEnd UTR 19553652 19554362 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC00896 NR_026919 20193854 20196060 2206 0 0 no 1 txStart-txEnd UTR 20193854 20196060 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC01311 NR_103767 19159218 19160345 1127 0 0 no 1 txStart-txEnd UTR 19159218 19160345 gnomAD-SV_v2.1_DUP_22_50680 22:19158000-19164000 0.1500 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC01637 NR_110537 21311379 21318968 7589 0 0 no 2 txStart-txEnd UTR 21311379 21318968 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LOC102724770 NM_001368242 18893832 18899601 4766 392 59 yes 5 intron2-txEnd CDS-3'UTR 597 5' 18894835 18899601 DDD:56146;DDD:56173;DDD:56174;dgv543n27;dgv99e203;gnomAD-SV_v2.1_DUP_22_50647 22:18884850-18926400;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;22:18655861-19006984;22:18667571-18994853 0.0355 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LOC102724788 NM_001368249 18900293 18923806 23513 1803 100 no 14 txStart-txEnd 5'UTR-3'UTR 18900293 18923806 dbVar:nssv17171558;dbVar:nssv17649973;dbVar:nssv17971399 22:18900295-18923806;22:18900689-18923800;22:18910311-18923800 3 Inborn_genetic_diseases;Proline_dehydrogenase_deficiency DDD:56146;DDD:56173;DDD:56174;dgv543n27;dgv99e203;gnomAD-SV_v2.1_DUP_22_50647 22:18884850-18926400;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;22:18655861-19006984;22:18667571-18994853 0.0355 14568;227094;540341;64889;73372;74042;81317 loss full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LOC107987389 NR_166643 20328514 21546450 1135605 0 0 no 14 txStart-intron8 UTR 73589 3' 20328514 21464119 dbVar:nssv15121202;dbVar:nssv15132429;dbVar:nssv15132430;dbVar:nssv15132749;dbVar:nssv15133531;dbVar:nssv15138177;dbVar:nssv15140282;dbVar:nssv15141369 22:20895156-21374512;22:20958985-21379958;22:21044197-21440455;22:21045039-21455556;22:21065883-21440455;22:21081261-21440455;22:21086707-21445960;22:21300291-21331188 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR;Gastrointestinal defects and immunodeficiency syndrome 2, 619708 (3) AR;Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis, 616531 (3) AR;Spastic paraplegia 84, AR, 619621 (3) AR;Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;Schwannomatosis-2, susceptibility to, 615670 (3) AD;Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD;Van den Ende-Gupta syndrome, 600920 (3) AR dbVar:nssv15120710;dbVar:nssv15124351;dbVar:nssv15131088;dbVar:nssv15132939;dbVar:nssv15133817;dbVar:nssv15134361;dbVar:nssv15137759;dbVar:nssv15153165;dbVar:nssv15755310;dbVar:nssv15755712;dbVar:nssv16213307;dbVar:nssv16215255;dbVar:nssv16215257;dbVar:nssv16254739;dbVar:nssv16255831;dbVar:nssv16736634;dbVar:nssv17171582;dbVar:nssv17970829;dbVar:nssv17971092;morbid:LZTR1;morbid:PI4KA;morbid:SCARF2;morbid:SERPIND1;morbid:SNAP29 22:20708891-21407690;22:20718171-21427936;22:20733496-21463730;22:20745763-21460658;22:20754408-21440515;22:20754408-21457610;22:20754423-21461752;22:20778874-20792112;22:20921343-21459713;22:21061979-21213100;22:21062169-21463730;22:21062567-21463730;22:21065883-21455556;22:21067570-21414817;22:21069074-21463730;22:21074921-21440514;22:21075576-21454721;22:21081285-21457610;22:21128401-21142008;22:21213295-21245501;22:21335907-21346541;22:21336586-21353320;22:21336662-21337398;22:21336662-21351637 CLN:1349334;dbVar:nssv17974796 22:21337344-21337343;22:21337344-21337456 113 Autism_spectrum_disorder;CEDNIK_syndrome;Fetal_cystic_hygroma;Hypomyelinating_leukodystrophy_2;Inborn_genetic_diseases;Noonan_syndrome_10;Noonan_syndrome_2;Noonan_syndrome_and_Noonan-related_syndrome;Polymicrogyria,_perisylvian,_with_cerebellar_hypoplasia_and_arthrogryposis;RASopathy;Schwannomatosis;Schwannomatosis_2;See_cases;Short_stature;Van_den_Ende-Gupta_syndrome 1001305;1001306;1004361;1004362;1004363;1008233;1008234;1008235;1008392;1008397;1008404;1008412;1008416;1008428;1008433;1011827;1012827;1022682;1022683;1022684;1022685;1024387;1032892;1034393;1034396;1039603;1060873;1061246;1064115;1065051;1066059;1068660;1068661;1068662;1069644;1070188;1073865;1083185;1103508;11086;112394;1237141;1315910;133435;133436;133437;133438;1386821;143299;144607;144935;... gain;loss full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LOC107987394 NR_165500 20326403 20350462 24059 0 0 no 12 txStart-txEnd UTR 20326403 20350462 DDD:56225;DDD:56226 22:20313251-20369884;22:20322450-20718598 0.0509 DDD:56225;DDD:56226 22:20313251-20369884;22:20322450-20718598 0.0959 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LOC284865 NR_038460 20186251 20192441 6190 0 0 no 4 txStart-txEnd UTR 20186251 20192441 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LRRC74B NM_001291006 21400234 21418457 18223 1179 100 no 10 txStart-txEnd 5'UTR-3'UTR 21400234 21418457 CMRI:8_pbsv.SPLIT.DUP.222;esv2760719 22:21383283-21845355;22:21107405-21917116 0.1374 725000 loss full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LZTR1 NM_006767 21336585 21353320 16735 2523 100 no 21 txStart-txEnd 5'UTR-3'UTR 21336585 21353320 Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;Schwannomatosis-2, susceptibility to, 615670 (3) AD dbVar:nssv17171582;dbVar:nssv17971092;morbid:LZTR1 22:21336586-21353320;22:21336662-21337398;22:21336662-21351637 CLN:1349334;dbVar:nssv17974796 22:21337344-21337343;22:21337344-21337456 103 Autism_spectrum_disorder;Fetal_cystic_hygroma;Inborn_genetic_diseases;Noonan_syndrome_10;Noonan_syndrome_2;Noonan_syndrome_and_Noonan-related_syndrome;RASopathy;Schwannomatosis;Schwannomatosis_2;See_cases;Short_stature CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 687522 gain 32.82 -1.25119505668143 -1.28020537251329 -0.946080819110286 0.246895000414255 0.909128978651125 Noonan syndrome;Noonan syndrome 10;Noonan syndrome 2;schwannomatosis 2 AD;AR Definitive;Moderate;Strong;Supportive 24362817;25795793;25795793[PMID];29469822;30368668;30481304;30664951;30859559;31533111;31825158 600574 Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;(Schwannomatosis-2, susceptibility to), 615670 (3) AD AD;AR yes yes 9 1.0211e-92 3.3832e-52 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MED15 NM_001003891 20861896 20941906 80010 2367 100 no 18 txStart-txEnd 5'UTR-3'UTR 20861896 20941906 24.41 0.672972182845271 2.65389095774821 0 9.9974e-01 9.6081e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR1286 NR_031618 20236656 20236734 78 0 0 no 1 txStart-txEnd UTR 20236656 20236734 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR1306 NR_031706 20073580 20073665 85 0 0 no 1 txStart-txEnd UTR 20073580 20073665 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR185 NR_029706 20020661 20020743 82 0 0 no 1 txStart-txEnd UTR 20020661 20020743 gnomAD-SV_v2.1_DUP_22_50746 22:20017400-20023000 0.0111 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR3618 NR_037412 20073268 20073356 88 0 0 no 1 txStart-txEnd UTR 20073268 20073356 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR4761 NR_039918 19951275 19951357 82 0 0 no 1 txStart-txEnd UTR 19951275 19951357 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR649 NR_030379 21388464 21388561 97 0 0 no 1 txStart-txEnd UTR 21388464 21388561 CMRI:8_pbsv.SPLIT.DUP.222;esv2760719 22:21383283-21845355;22:21107405-21917116 0.1374 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR6816 NR_106874 20102208 20102274 66 0 0 no 1 txStart-txEnd UTR 20102208 20102274 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MRPL40 NM_003776 19419424 19423601 4177 621 100 no 4 txStart-txEnd 5'UTR-3'UTR 19419424 19423601 54.99 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.0822917398873284 -0.450618700229176 4 5.2924e-02 2.0082e-02 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 P2RX6 NM_005446 21369448 21382302 12854 1326 100 no 12 txStart-txEnd 5'UTR-3'UTR 21369448 21382302 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 724998 loss 76.26 -1.8606303493434 -1.51336493990188 -1.2805127161158 -0.990180484365383 -0.63060581685217 6 4.4680e-09 1.8785e-07 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 P2RX6P NR_002829 21396680 21398538 1858 0 0 no 2 txStart-txEnd UTR 21396680 21398538 CMRI:8_pbsv.SPLIT.DUP.222;esv2760719 22:21383283-21845355;22:21107405-21917116 0.1374 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 PI4KA NM_058004 21061978 21213099 151121 6309 100 no 55 txStart-txEnd 5'UTR-3'UTR 21061978 21213099 Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD morbid:SERPIND1 22:21128401-21142008 2 Polymicrogyria,_perisylvian,_with_cerebellar_hypoplasia_and_arthrogryposis 1060873;1061246;1065051;1066059;1068660;1068661;1068662;1069644;1070188;1073865;2069010;263494;367925;513199;724990;724991;724992;724993;724994;724995;75440;768172;768173 gain;loss 35.17 1.20573288011437 5.29477062168781 polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis AR Moderate 25855803 600286 Gastrointestinal defects and immunodeficiency syndrome 2, 619708 (3) AR;Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis, 616531 (3) AR;Spastic paraplegia 84, AR, 619621 (3) AR AR yes 2 3.1234e-12 8.0407e-04 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 PI4KAP1 NR_003563 20383730 20398695 14965 0 0 no 15 txStart-txEnd UTR 20383730 20398695 DDD:56226;DDD:56232 22:20322450-20718598;22:20330330-20450295 0.0509 DDD:56226;DDD:56232;gnomAD-SV_v2.1_DEL_22_181447 22:20366424-20403000;22:20322450-20718598;22:20330330-20450295 0.0749 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 POM121L4P NR_024592 21043842 21046009 2167 0 0 no 1 txStart-txEnd UTR 21043842 21046009 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 PRODH NM_016335 18900293 18923806 23513 1803 100 no 14 txStart-txEnd 5'UTR-3'UTR 18900293 18923806 dbVar:nssv17171558;dbVar:nssv17649973;dbVar:nssv17971399 22:18900295-18923806;22:18900689-18923800;22:18910311-18923800 3 Inborn_genetic_diseases;Proline_dehydrogenase_deficiency DDD:56146;DDD:56173;DDD:56174;dgv543n27;dgv99e203;gnomAD-SV_v2.1_DUP_22_50647 22:18884850-18926400;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;22:18655861-19006984;22:18667571-18994853 0.0355 14568;227094;540341;64889;73372;74042;81317 loss 45.38 0.360135634788785 0.772811927860626 hyperprolinemia type 1 AR Definitive;Strong;Supportive 12217952;15662599;19736351;20524212;20524212[PMID]_23462603[PMID];28202261;28851938 606810 Hyperprolinemia, type I, 239500 (3) AR;(Schizophrenia, susceptibility to, 4), 600850 (3) AD AD;AR yes yes 6 5.3577e-12 4.7536e-06 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RANBP1 NM_001278639 20103626 20114878 11252 837 100 no 6 txStart-txEnd 5'UTR-3'UTR 20103626 20114878 724972 loss 8.76 -2.62354415217069 -2.53125239294469 -2.47162789907313 -1.04492215962902 2.06932219421127 2 8.2235e-01 3.3622e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RIMBP3 NM_015672 20455681 20461786 6105 4920 91 no 1 txStart-txEnd 5'UTR-3'UTR 20455681 20461786 DDD:56226;gnomAD-SV_v2.1_DUP_22_50781 22:20451000-20466000;22:20322450-20718598 0.1528 DDD:56226;HI40:ISCA-46728;dgv817e199 22:20322450-20718598;22:20423846-20488792;22:20428071-20499197 0.0300 90.21 7 9.0005e-09 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RTL10 NM_024627 19833668 19842397 8729 1095 82 no 3 txStart-txEnd 5'UTR-3'UTR 19833668 19842397 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RTN4R NM_023004 20228937 20255841 26904 1422 100 no 2 txStart-txEnd 5'UTR-3'UTR 20228937 20255841 35.77 -0.800223805913347 1.18081437151802 605566 (Schizophrenia, susceptibility to), 181500 (3) AD AD yes 1 9.5882e-01 5.2644e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SCARF2 NM_153334 20778873 20792112 13239 2612 100 yes 14 txStart-txEnd 5'UTR-3'UTR 20778873 20792112 Van den Ende-Gupta syndrome, 600920 (3) AR morbid:SCARF2 22:20778874-20792112 2 Van_den_Ende-Gupta_syndrome 1011827;329413;334666;342985 gain;loss 30 0 70.17 -1.42333559636086 -1.93669033911618 -1.61173791689534 van den Ende-Gupta syndrome AR Definitive;Limited;Moderate;Supportive 20887961[PMID]_22140376[PMID];21108395;23808541 613619 Van den Ende-Gupta syndrome, 600920 (3) AR AR yes 0 9.9980e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SEPT5-GP1BB NR_037611 19704742 19712297 7555 0 0 no 12 txStart-txEnd UTR 19704742 19712297 Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR morbid:GP1BB 22:19711062-19712294 4 Bernard_Soulier_syndrome;Macrothrombocytopenia;Thrombocytopenia full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SEPTIN5 NM_002688 19702025 19710842 8817 1110 100 no 12 txStart-txEnd 5'UTR-3'UTR 19702025 19710842 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SERPIND1 NM_000185 21128400 21142008 13608 1500 100 no 5 txStart-txEnd 5'UTR-3'UTR 21128400 21142008 Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD morbid:SERPIND1 22:21128401-21142008 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 724992;724993 loss 68.88 -1.06265755233802 -1.49456297636655 -1.03231231326932 -0.289055396385536 -0.349034099945665 heparin cofactor 2 deficiency AD Definitive;Strong 142360 Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD AD yes 8 2.5137e-10 2.7955e-05 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SLC25A1 NM_001256534 19163093 19166018 2925 957 100 no 8 txStart-txEnd 5'UTR-3'UTR 19163093 19166018 6 2-hydroxyglutaric_aciduria;D,L-2-hydroxyglutaric_aciduria;Myasthenic_syndrome,_congenital,_23,_presynaptic 30 46.07 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.459211010381399 1.99698466418685 D,L-2-hydroxyglutaric aciduria;myasthenic syndrome, congenital, 23, presynaptic;presynaptic congenital myasthenic syndrome AD;AR Limited;Strong;Supportive 23561848;23561848[PMID]_23393310[PMID];26273529;26870663;29238895;31527857;NULL 190315 Combined D-2- and L-2-hydroxyglutaric aciduria, 615182 (3) AR;Myasthenic syndrome, congenital, 23, presynaptic, 618197 (3) AR AR yes 3 5.8829e-02 6.3354e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SLC7A4 NM_004173 21383006 21386850 3844 1908 100 no 5 txStart-txEnd 5'UTR-3'UTR 21383006 21386850 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 74.02 -0.807902299547855 -1.26588610868392 -1.04316708587741 -0.387275128092876 -1.12481109733158 6 2.8317e-07 1.0047e-04 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SNAP29 NM_004782 21213294 21245501 32207 777 100 no 5 txStart-txEnd 5'UTR-3'UTR 21213294 21245501 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR morbid:SNAP29 22:21213295-21245501 6 CEDNIK_syndrome;Hypomyelinating_leukodystrophy_2 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 30 61.36 -1.39880243235913 -1.53414994058354 -1.19910660480315 1.58078637399342 -0.841707455415557 CEDNIK syndrome AR Strong;Supportive 15968592;15968592[PMID]_21073448[PMID];21073448 604202 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR AR yes 4 1.3567e-02 1.5166e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SNORA77B NR_145765 20113924 20114049 125 0 0 no 1 txStart-txEnd UTR 20113924 20114049 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TANGO2 NM_001322141 20008591 20054687 46096 1110 100 no 9 txStart-txEnd 5'UTR-3'UTR 20008591 20054687 Cardiac_arrhythmia|Intellectual_disability|Seizure|Episodic_flaccid_weakness|Acute_rhabdomyolysis|Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome;Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, 616878 (3) AR HP:0000730;HP:0001249;HP:0001250;HP:0001267;HP:0001275;HP:0001286;HP:0001303;HP:0001656;HP:0001661;HP:0001665;HP:0001666;HP:0001687;HP:0001721;HP:0002122;HP:0002125;HP:0002182;HP:0002192;HP:0002279;HP:0002306;HP:0002316;HP:0002348;HP:0002382;HP:0002386;HP:0002391;HP:0002402;HP:0002417;HP:0002430;HP:0002431;HP:0002432;HP:0002434;HP:0002437;HP:0002458;HP:0002466;HP:0002479;HP:0002482;HP:0002499;HP:0002543;HP:0002794;HP:0003752;HP:0003767;HP:0004351;HP:0005158;HP:0006833;HP:0006997;HP:0007154;HP:0007176;HP:0007180;HP:0008942;HP:0010520;HP:0011675 CLN:226591;dbVar:nssv15770877;dbVar:nssv15772938;nssv15773614;nssv15775115;nssv15775184;nssv15775592;dbVar:nssv15772982;dbVar:nssv15775129;dbVar:nssv16216543;dbVar:nssv17171771;dbVar:nssv17171772;dbVar:nssv17971094;dbVar:nssv8639589;nssv15122532;morbid:TANGO2 22:20008633-20054687;22:20028564-20053554;22:20030823-20041691;22:20030823-20053554;22:20030859-20052185;22:20030879-20049206;22:20030879-20052185;22:20036383-20045782;22:20036384-20045781;22:20036385-20045784;22:20052066-20052185 12 Abnormality_of_metabolism/homeostasis;Acute_rhabdomyolysis;Cardiac_arrhythmia;Episodic_flaccid_weakness;Inborn_genetic_diseases;Intellectual_disability;Metabolic_crises_with_rhabdomyolysis,_cardiac_arrhythmias,_and_neurodegeneration;Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome;Seizure 286870;290503;290504;301777;545395 gain;loss 51.91 -2.62354415217069 -2.53125239294469 -2.47162789907313 1.46130508236304 0.279301120222081 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration AR Moderate;Strong 26805782 616830 Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, 616878 (3) AR AR yes 4 1.4769e-04 4.2224e-06 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TBX1 NM_001379200 19748300 19754857 6557 1515 100 no 7 txStart-txEnd 5'UTR-3'UTR 19748300 19754857 Conotruncal anomaly face syndrome, 217095 (3);DiGeorge syndrome, 188400 (3) AD;Tetralogy of Fallot, 187500 (3) AD;Velocardiofacial syndrome, 192430 (3) AD;DiGeorge_syndrome CLN:959024;morbid:TBX1 22:19748301-19754857;22:19748451-19748647 18 DiGeorge_syndrome;Inborn_genetic_diseases 2 0 4.92 -2.62354415217069 -2.53125239294469 -2.47162789907313 2.36782594176173 3.38001100960461 22q11.2 deletion syndrome;DiGeorge syndrome;conotruncal heart malformations;velocardiofacial syndrome AD Definitive;Strong;Supportive 14585638;14585638[PMID] 602054 Conotruncal anomaly face syndrome, 217095 (3);DiGeorge syndrome, 188400 (3) AD;Tetralogy of Fallot, 187500 (3) AD;Velocardiofacial syndrome, 192430 (3) AD AD yes 2 8.3661e-01 9.8340e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 THAP7 NM_030573 21353392 21356407 3015 930 100 no 4 txStart-txEnd 5'UTR-3'UTR 21353392 21356407 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 50.87 -1.44618961523547 -1.52989215323949 -1.19895133869269 -1.50983365445593 1.16392737773964 4 1.3291e-02 2.9328e-02 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 THAP7-AS1 NR_027051 21356210 21364663 8453 0 0 no 2 txStart-txEnd UTR 21356210 21364663 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TMEM191A NR_026815 21055401 21058891 3490 0 0 no 8 txStart-txEnd UTR 21055401 21058891 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TMEM191B NM_001242313 20377668 20380440 2772 1041 100 no 9 txStart-txEnd 5'UTR-3'UTR 20377668 20380440 DDD:56226;DDD:56232;DDD:56234;gnomAD-SV_v2.1_DUP_22_50780 22:20333000-20381150;22:20343574-20380608;22:20322450-20718598;22:20330330-20450295 0.0620 DDD:56226;DDD:56232;DDD:56234;gnomAD-SV_v2.1_DEL_22_181447 22:20343574-20380608;22:20366424-20403000;22:20322450-20718598;22:20330330-20450295 0.0749 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TRMT2A NM_001331039 20099397 20104749 5352 1932 100 no 12 txStart-txEnd 5'UTR-3'UTR 20099397 20104749 68.23 -2.62354415217069 -2.53125239294469 -2.47162789907313 -1.98609532754524 -0.363927890852326 5 1.0841e-08 1.3059e-05 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TSSK2 NM_053006 19118820 19120135 1315 1077 88 no 1 txStart-txEnd 5'UTR-3'UTR 19118820 19120135 33.13 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.184731887964386 1.02819617031079 6 3.8610e-03 4.1565e-03 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TUBA3FP NR_003608 21362495 21368576 6081 0 0 no 3 txStart-txEnd UTR 21362495 21368576 CMRI:8_pbsv.SPLIT.DUP.222 22:21107405-21917116 0.1374 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TXNRD2 NM_006440 19863044 19929341 66297 1575 100 no 18 txStart-txEnd 5'UTR-3'UTR 19863044 19929341 1064219;1066921;1068069;367919;485936;724968;724969;778842;979497;98439;98826;98831 gain;loss 72.21 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.348188483468328 0.327140414338646 dilated cardiomyopathy;familial glucocorticoid deficiency;familial isolated dilated cardiomyopathy AD;AR Limited;Supportive 21247928[PMID];24601690[PMID] 606448 ?Glucocorticoid deficiency 5, 617825 (3) AR AR yes 5 3.4688e-11 1.0692e-08 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 UFD1 NM_005659 19437433 19466716 29283 924 100 no 12 txStart-txEnd 5'UTR-3'UTR 19437433 19466716 724954;724955;724956;768151 gain;loss full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ZDHHC8 NM_001185024 20119326 20135530 16204 2337 100 no 11 txStart-txEnd 5'UTR-3'UTR 20119326 20135530 768162 loss 37.82 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.408428770523539 2.39258092860216 1 8.5288e-01 9.8899e-01 full=5 -22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ZNF74 NM_001256524 20748404 20762753 14349 1935 100 no 6 txStart-txEnd 5'UTR-3'UTR 20748404 20762753 86.28 -1.30437956536809 -1.89912490049618 -1.51976012533128 2.28676628831896 2.39892044394279 4 1.5586e-06 3.5588e-04 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA full p16.3-p16.1 ABCA11P;ABLIM2;ACOX3;ADD1;ADRA2C;AFAP1;AFAP1-AS1;ATP5ME;BLOC1S4;C4orf48;C4orf50;CCDC96;CFAP99;CPLX1;CPZ;CRMP1;CTBP1;CTBP1-AS;CTBP1-DT;CYTL1;DGKQ;DOK7;EVC;EVC2;FAM193A;FAM53A;FAM86EP;FAM90A26;FGFR3;FGFRL1;GAK;GPR78;GRK4;GRPEL1;HAUS3;HGFAC;HMX1;HTRA3;HTT;HTT-AS;IDUA;JAKMIP1;KIAA0232;LETM1;LINC00955;LINC01396;LINC01587;LINC02171;LINC02447;LINC02481;LINC02482;LINC02495;LINC02517;LOC100129917;LOC100129931;LOC100130872;LOC101928279;LOC101928306;LOC105374338;LOC105374344;LOC389199;LOC93622;LRPAP1;LYAR;MAEA;MAN2B2;MFSD10;MIR378D1;MIR4274;MIR4798;MIR4800;MIR571;MIR943;MIR95;MRFAP1;MRFAP1L1;MSANTD1;MSX1;MXD4;MYL5;NAT8L;NELFA;NKX1-1;NOP14;NOP14-AS1;NSD2;NSG1;OTOP1;PCGF3;PDE6B;PIGG;POLN;PPP2R2C;PSAPL1;RGS12;RNF212;RNF4;S100P;SCARNA22;SH3BP2;SH3TC1;SLBP;SLC26A1;SLC49A3;SNORD162;SORCS2;SPON2;STK32B;STX18;STX18-AS1;STX18-IT1;TACC3;TADA2B;TBC1D14;TMED11P;TMEM128;TMEM129;TMEM175;TMEM271;TNIP2;TRMT44;USP17L10;USP17L11;USP17L12;USP17L13;USP17L15;USP17L17;USP17L18;USP17L19;USP17L20;USP17L21;USP17L22;USP17L24;USP17L25;USP17L26;USP17L27;USP17L28;USP17L29;USP17L30;USP17L5;USP17L6P;USP17L9P;UVSSA;WFS1;ZBTB49;ZFYVE28;ZNF141;ZNF595;ZNF718;ZNF721;ZNF732;ZNF876P 152 ACTC1 (morbid/RE=mTL_miRNA);ACVR1 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AKT1 (morbid/RE=mTL_miRNA);ANTXR2 (morbid/RE=mTL_miRNA);ARF1 (morbid/RE=mTL_miRNA);ARHGDIA (morbid/RE=mTL_miRNA);ARPC1B (morbid/RE=mTL_miRNA);ATXN2 (morbid/RE=mTL_miRNA);CAD (morbid/RE=mTL_miRNA);CALM2 (morbid/RE=mTL_miRNA);CASK (morbid/RE=mTL_miRNA);CCNF (morbid/RE=mTL_miRNA);CELF2 (morbid/RE=mTL_miRNA);CEP55 (morbid/RE=mTL_miRNA);CIITA (morbid/RE=mTL_miRNA);CNTNAP2 (morbid/RE=mTL_miRNA);COL18A1 (morbid/RE=mTL_miRNA);COL1A1 (HI=3/morbid/RE=mTL_miRNA);CREBBP (HI=3/morbid/RE=mTL_miRNA);CTCF (HI=3/morbid/RE=mTL_miRNA);DAAM2 (morbid/RE=mTL_miRNA);DDR2 (morbid/RE=mTL_miRNA);DDX3X (HI=3/morbid/RE=mTL_miRNA);EDEM3 (morbid/RE=mTL_miRNA);EGLN1 (morbid/RE=mTL_miRNA);ELOVL5 (morbid/RE=mTL_miRNA);ESCO2 (morbid/RE=mTL_miRNA);FLCN (HI=3/morbid/RE=mTL_miRNA);FLVCR1 (morbid/RE=mTL_miRNA);FOXC1 (HI=3/morbid/RE=mTL_miRNA);FOXP2 (morbid/RE=mTL_miRNA);G6PD (morbid/RE=mTL_miRNA);GABRB2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GLI2 (HI=3/morbid/RE=mTL_miRNA);GLUL (morbid/RE=mTL_miRNA);GNAS (HI=3/morbid/RE=mTL_miRNA);HERC2 (morbid/RE=mTL_miRNA);HFE (morbid/RE=mTL_miRNA);IGF1R (morbid/RE=mTL_miRNA);INF2 (morbid/RE=mTL_miRNA);ITM2B (morbid/RE=mTL_miRNA);KCNJ6 (morbid/RE=mTL_miRNA);LAMA4 (morbid/RE=mTL_miRNA);LMNB2 (morbid/RE=mTL_miRNA);LRP6 (morbid/RE=mTL_miRNA);MED13 (morbid/RE=mTL_miRNA);MEN1 (HI=3/morbid/RE=mTL_miRNA);MMADHC (morbid/RE=mTL_miRNA);MOCS2 (morbid/RE=mTL_miRNA);MRAS (morbid/RE=mTL_miRNA);MYRF (morbid/RE=mTL_miRNA);NCKAP1 (HI=3/RE=mTL_miRNA);NDST1 (morbid/RE=mTL_miRNA);NOTCH2 (morbid/RE=mTL_miRNA);NUP93 (morbid/RE=mTL_miRNA);OCRL (HI=3/morbid/RE=mTL_miRNA);P4HB (morbid/RE=mTL_miRNA);PEX10 (morbid/RE=mTL_miRNA);PLAA (morbid/RE=mTL_miRNA);PNPO (morbid/RE=mTL_miRNA);PRNP (morbid/RE=mTL_miRNA);PRPF6 (morbid/RE=mTL_miRNA);PUM1 (morbid/RE=mTL_miRNA);RAD51 (morbid/RE=mTL_miRNA);RAI1 (HI=3/morbid/RE=mTL_miRNA);REL (morbid/RE=mTL_miRNA);REST (morbid/RE=mTL_miRNA);RLIM (morbid/RE=mTL_miRNA);SAMD12 (morbid/RE=mTL_miRNA);SCD (morbid/RE=mTL_miRNA);SDHD (HI=3/morbid/RE=mTL_miRNA);SET (morbid/RE=mTL_miRNA);SF1 (morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC1A4 (morbid/RE=mTL_miRNA);SLC25A46 (morbid/RE=mTL_miRNA);SLC27A4 (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SOX4 (morbid/RE=mTL_miRNA);SREBF1 (morbid/RE=mTL_miRNA);SUZ12 (morbid/RE=mTL_miRNA);TBX18 (morbid/RE=mTL_miRNA);TBX20 (morbid/RE=mTL_miRNA);TGFB2 (morbid/RE=mTL_miRNA);TRIP13 (morbid/RE=mTL_miRNA);TRIP4 (morbid/RE=mTL_miRNA);TUBB2A (morbid/RE=mTL_miRNA);USP8 (morbid/RE=mTL_miRNA);WDR35 (morbid/RE=mTL_miRNA);WDR45B (morbid/RE=mTL_miRNA);YY1 (morbid/RE=mTL_miRNA);ZC3H14 (morbid/RE=mTL_miRNA);ZNF699 (morbid/RE=mTL_miRNA);ZNF711 (morbid/RE=mTL_miRNA) Retinitis_pigmentosa|Retinitis_pigmentosa_40 HP:0000547 CLN:801370;dbVar:nssv15124412;dbVar:nssv15130095;dbVar:nssv15132150;dbVar:nssv15132411;dbVar:nssv15132589;dbVar:nssv15133497;dbVar:nssv15153559;dbVar:nssv15161020;dbVar:nssv16255833;dbVar:nssv16867404;dbVar:nssv17172169;dbVar:nssv17973849 4:127234-8667610;4:1420949-1836794;4:1737489-1808653;4:1770487-2303110;4:374558-745174;4:5567009-5587839;4:5785270-5803831;4:614356-2959936;4:619584-619584;4:619590-619662;4:72448-3848881;4:72448-5608810;4:85041-4597934 4p16.3 terminal (Wolf-Hirschhorn syndrome) region;?Cataract 41, 116400 (3) AD;Deafness, AD 6;14;38, 600965 (3) AD;Wolfram syndrome 1, 222300 (3) AR;Wolfram-like syndrome, AD, 614296 (3) AD;Diabetes mellitus, noninsulin-dependent, association with, 125853 (3) AD;?Spermatogenic failure 62, 619673 (3) AR;Recombination rate QTL 1, 612042 (3);?Weyers acrofacial dysostosis, 193530 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR;Achondroplasia, 100800 (3) AD;Bladder cancer, somatic, 109800 (3);CATSHL syndrome, 610474 (3) AR,AD;Cervical cancer, somatic, 603956 (3);Colorectal cancer, somatic, 114500 (3);Crouzon syndrome with acanthosis nigricans, 612247 (3) AD;Hypochondroplasia, 146000 (3) AD;LADD syndrome, 149730 (3) AD;Muenke syndrome, 602849 (3) AD;Nevus, epidermal, somatic, 162900 (3);SADDAN, 616482 (3) AD;Spermatocytic seminoma, somatic, 273300 (3);Thanatophoric dysplasia, type I, 187600 (3) AD;Thanatophoric dysplasia, type II, 187601 (3) AD;Cherubism, 118400 (3) AD;Curry-Hall_syndrome|Ellis-van_Creveld_syndrome;Developmental and epileptic encephalopathy 63, 617976 (3) AR;Ectodermal dysplasia 3, Witkop type, 189500 (3) AD;Orofacial cleft 5, 608874 (3) AD;Tooth agenesis, selective, 1, with or without orofacial cleft, 106600 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR;Weyers acrofacial dysostosis, 193530 (3) AD;Fetal akinesia deformation sequence 3, 618389 (3) AR;Myasthenic syndrome, congenital, 10, 254300 (3) AR;Huntington disease, 143100 (3) AD;Lopes-Maciel-Rodan syndrome, 617435 (3) AR;Anxiety-related personality traits, 607834 (3);Obsessive-compulsive disorder, 164230 (3) AD;Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome, 617915 (3) AD;Mucopolysaccharidosis Ih, 607014 (3) AR;Mucopolysaccharidosis Ih;s, 607015 (3) AR;Mucopolysaccharidosis Is, 607016 (3) AR;Mucopolysaccharidosis_type_1;Myopia 23, AR, 615431 (3) AR;Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy, 616917 (3) AR;Blood group, EMM system, 619812 (3) AR;Night blindness, congenital stationary, AD 2, 163500 (3) AD;Retinitis pigmentosa-40, 613801 (3) AR;Oculoauricular syndrome, 612109 (3) AR;Rauch-Steindl syndrome, 619695 (3) AD;UV-sensitive syndrome 3, 614640 (3) AR;Vitreoretinopathy, neovascular inflammatory, 193235 (3) AD CLN:1313135;CLN:961843;HI3:ISCA-37429;HI3:MSX1;dbVar:nssv15119851;dbVar:nssv15121023;dbVar:nssv15121032;dbVar:nssv15121033;dbVar:nssv15121034;dbVar:nssv15121217;dbVar:nssv15121218;dbVar:nssv15121687;dbVar:nssv15122678;dbVar:nssv15123516;dbVar:nssv15124520;dbVar:nssv15127349;dbVar:nssv15130945;dbVar:nssv15131476;dbVar:nssv15131910;dbVar:nssv15132407;dbVar:nssv15132408;dbVar:nssv15132580;nssv15140019;dbVar:nssv15132953;dbVar:nssv15133489;dbVar:nssv15133490;dbVar:nssv15133634;dbVar:nssv15134794;dbVar:nssv15134826;dbVar:nssv15135086;dbVar:nssv15135107;dbVar:nssv15138367;dbVar:nssv15138802;dbVar:nssv15138941;dbVar:nssv15139309;dbVar:nssv15144315;dbVar:nssv15147286;dbVar:nssv15153560;dbVar:nssv15153562;dbVar:nssv15605891;dbVar:nssv15606061;dbVar:nssv15770186;dbVar:nssv15770321;dbVar:nssv16211870;dbVar:nssv16212102;dbVar:nssv16213046;dbVar:nssv16213271;dbVar:nssv16213451;dbVar:nssv16213637;dbVar:nssv16213802;dbVar:nssv16214176;dbVar:nssv16214333;dbVar:nssv16216714;dbVar:nssv16252200;dbVar:nssv16253953;dbVar:nssv16254938;dbVar:nssv16297119;dbVar:nssv16297131;dbVar:nssv16867405;dbVar:nssv17171362;dbVar:nssv17171376;dbVar:nssv17171391;dbVar:nssv17171923;dbVar:nssv17172168;dbVar:nssv17172572;dbVar:nssv17172573;dbVar:nssv17172574;dbVar:nssv17172955;dbVar:nssv17173143;dbVar:nssv17173159;dbVar:nssv17683620;dbVar:nssv17970729;dbVar:nssv17970732;dbVar:nssv17971217;dbVar:nssv17971266;dbVar:nssv17971361;dbVar:nssv17971686;dbVar:nssv17971734;dbVar:nssv17971799;dbVar:nssv17971903;dbVar:nssv17971904;dbVar:nssv17972056;dbVar:nssv17972166;dbVar:nssv17972432;dbVar:nssv17973718;nssv17974037;dbVar:nssv17973748;dbVar:nssv17974578;dbVar:nssv17975024;dbVar:nssv17976233;dbVar:nssv17976464;dbVar:nssv17976477;morbid:CPLX1;morbid:CTBP1;morbid:DOK7;morbid:EVC;morbid:EVC2;morbid:FGFR3;morbid:HMX1;morbid:HTRA3;morbid:HTT;morbid:IDUA;morbid:LRPAP1;morbid:MSX1;morbid:NSD2;morbid:PDE6B;morbid:PIGG;morbid:RNF212;morbid:SH3BP2;morbid:UVSSA;morbid:WFS1 4:1087097-1107352;4:1190912-2255904;4:1205233-1244143;4:1228529-2862002;4:129754-9371067;4:1305803-2460571;4:1341344-1381837;4:1619776-2181192;4:1701019-1975031;4:1784695-1919793;4:1795039-1810599;4:1827029-1860753;4:1902353-1950545;4:1941634-3879802;4:1966267-5913899;4:2009467-3080412;4:2200252-5710240;4:2364202-5447465;4:2820541-2842823;4:2909441-6871516;4:3076408-3245687;4:3085428-7591673;4:331569-2010962;4:3465094-3495238;4:3465104-3465298;4:3475114-3491543;4:3486271-3496209;4:3487104-3487370;4:3487247-3495248;4:3487257-3487395;4:3487257-3495238;4:3505339-3534149;4:3776785-7361544;4:388345-3872380;4:4861392-4865660;4:4861393-4865663;4:492999-533989;4:493126-2065854;4:493126-2886413;4:493126-998181;4:493969-499930;4:499508-502759;4:502599-509994;4:507006-2214932;4:512203-518547;4:5563147-5711294;4:5564166-5710286;4:5564566-5586587;4:5564566-5759862;4:5564576-5567096;4:5565511-5811251;4:5570162-5570377;4:5630277-5633769;4:5630338-5635927;4:5636440-5710337;4:5642222-5642585;4:5682978-5735172;4:5690875-5691080;4:5696053-5696238;4:5711925-5817031;4:5712928-5816032;4:5731025-5759862;4:5733143-5735172;4:5749726-5755670;4:5754554-5755670;4:5754599-5758602;4:5795340-5795484;4:5795341-5795483;4:5798730-5798979;4:5798740-5798969;4:5803668-5806578;4:5809919-5811348;4:619417-619883;4:6271577-6304992;4:629670-670728;4:646966-664571;4:647642-648677;4:652722-656427;4:72448-2110334;4:72448-2327204;4:72448-2691306;4:72448-3208040;4:72448-3563382;4:72448-3725774;4:72448-3787112;4:72448-4360445;4:72448-4889835;4:72448-5036718;4:72448-5214111;4:72448-5346537;4:72448-6245152;4:72448-7831152;4:75743-8672411;4:778745-819917;4:78471-3364946;4:8271481-8308825;4:85041-1921232;4:85041-2010262;4:85041-4407509;4:85041-7065426;4:85041-7845343;4:8613755-8873340;4:8868774-8873565;4:980776-981747;4:993498-998345;4:994391-998355;4:996510-998192;4:996511-998191;4:996511-998355 dbVar:nssv15165478;dbVar:nssv15148693;dbVar:nssv15149137;dbVar:nssv15125120;dbVar:nssv15134956;dbVar:nssv15136789;dbVar:nssv15148117;dbVar:nssv15165480;dbVar:nssv15164282;dbVar:nssv15164281;dbVar:nssv16215300;dbVar:nssv15145847;dbVar:nssv15132087;dbVar:nssv15132302;dbVar:nssv16254944;dbVar:nssv16207938;dbVar:nssv15150724;dbVar:nssv15777261;dbVar:nssv15151365;dbVar:nssv15150634;dbVar:nssv15142189;dbVar:nssv15149870;nssv15151360;dbVar:nssv17649922;dbVar:nssv15147407;dbVar:nssv15146379;dbVar:nssv15146614;dbVar:nssv15148043;dbVar:nssv15146983;dbVar:nssv15146984;dbVar:nssv15164312;dbVar:nssv15149115 4:11526-191028879;4:12441-190904441;4:12441-49064044;4:33575-6632513;4:36425-1583294;4:36425-4098729;4:36425-47493612;4:49451-190915650;4:49451-190963766;4:49451-46339070;4:49451-49620898;4:51414-17799819;4:51414-3776843;4:51414-8224525;4:68346-2503033;4:68346-27423424;4:68346-3713599;4:68346-4051616;4:68346-49089361;4:68346-66440622;4:68346-8731855;4:68347-190957473;4:69672-29702595;4:72448-21024037;4:72448-33132242;4:72448-39478764;4:78471-15627196;4:85041-22451641;4:85041-38701987;4:1356925-49659859;4:6447049-20490737 4.87;4.87;18.96;99.42;97.73;99.14;19.60;4.87;4.87;20.09;18.76;52.40;99.46;99.75;99.87;34.00;99.91;99.92;18.97;14.01;99.96;4.87;31.38;44.38;28.13;23.60;59.76;41.52;24.05;16.59;20.82 dbVar:nssv16254942;dbVar:nssv15140532;dbVar:nssv15129769;dbVar:nssv15124924;dbVar:nssv15139152;dbVar:nssv15136460;dbVar:nssv15138769;dbVar:nssv15136794;dbVar:nssv15139111;dbVar:nssv15145893;dbVar:nssv15145934;dbVar:nssv15134095;dbVar:nssv15147322;dbVar:nssv8639431;dbVar:nssv15164280;dbVar:nssv16208663;dbVar:nssv15123439;dbVar:nssv15135098;dbVar:nssv15146364;dbVar:nssv15121022;dbVar:nssv15119845;dbVar:nssv16207942;dbVar:nssv15151269;dbVar:nssv15149902;dbVar:nssv15146789;dbVar:nssv15151109;dbVar:nssv17957198;dbVar:nssv15137532;dbVar:nssv15148266;dbVar:nssv17956854;dbVar:nssv16254943;dbVar:nssv16207937;dbVar:nssv15152168;dbVar:nssv15141218;dbVar:nssv16254952;dbVar:nssv15150277;dbVar:nssv16254953;dbVar:nssv15139308;dbVar:nssv16207941;dbVar:nssv15138820;nssv16207940;dbVar:nssv16207939;dbVar:nssv17649921;dbVar:nssv15150501;dbVar:nssv15146961;dbVar:nssv15146716;dbVar:nssv15147405;dbVar:nssv15146665;dbVar:nssv15146669;dbVar:nssv15146272;dbVar:nssv15146661;dbVar:nssv15146276;dbVar:nssv15774427;dbVar:nssv15151369;dbVar:nssv15145981;dbVar:nssv16207944 4:2-1328868;4:29215-1925508;4:33575-2356516;4:33575-4534781;4:36425-1957819;4:36425-3267258;4:36425-3883057;4:36425-3975771;4:36425-7361544;4:36425-9371067;4:37337-15870679;4:37337-3776839;4:37337-9370984;4:44021-19796182;4:49451-2010397;4:49451-24280482;4:49451-8872474;4:51414-1399150;4:56773-14501384;4:56773-2214932;4:56773-3872380;4:68346-10312798;4:68346-10336032;4:68346-13770107;4:68346-14614077;4:68346-15973383;4:68346-1675143;4:68346-1999185;4:68346-20387231;4:68346-20587167;4:68346-2137211;4:68346-2786584;4:68346-3891984;4:68346-4044985;4:68346-5046326;4:68346-5319773;4:68346-5831521;4:68346-6056753;4:68346-6984507;4:68346-8731855;4:68346-9768141;4:68599-18912995;4:71553-15302739;4:71553-29006745;4:72448-10252290;4:72448-12900236;4:72448-15659658;4:72448-17279636;4:72448-28067931;4:78471-10337237;4:85041-17488365;4:3374196-13468480;4:4165335-33324781;4:4428131-17462172;4:5914110-17264668 94.62;97.77;98.37;99.16;98.17;98.91;99.09;99.11;99.52;99.62;58.73;99.09;99.63;47.08;98.87;38.38;99.75;98.51;64.38;99.32;99.61;90.78;90.57;67.87;63.93;58.47;99.80;99.83;45.77;45.32;99.84;99.88;99.92;99.92;99.94;99.94;99.94;99.95;99.95;99.96;95.87;49.35;61.06;32.14;91.34;72.49;59.66;54.04;33.21;90.58;53.36;59.41;17.85;37.92;30.46 612 4p_partial_monosomy_syndrome;Abnormality_of_the_cervical_spine;Abnormality_of_the_diaphragm;Abnormality_of_the_musculature;Abnormality_of_the_nervous_system;Abnormality_of_the_vertebral_column;Achondroplasia;Arachnodactyly;Autosomal_dominant_nonsyndromic_hearing_loss_6;Autosomal_recessive_retinitis_pigmentosa;Bell-shaped_thorax;Bowed_humerus;Camptodactyly-tall_stature-scoliosis-hearing_loss_syndrome;Cancer_of_cervix;Carcinoma;Carcinoma_of_colon;Cataract_41;Cerebellar_vermis_hypoplasia;Cleft_palate;Cone-rod_dystrophy;Congenital_laryngomalacia;Congenital_myasthenic_syndrome;Congenital_myasthenic_syndrome_10;Congenital_stationary_night_blindness_autosomal_dominant_2;Connective_tissue_disorder;Coronal_craniosynostosis;Craniosynostosis_syndrome;Crouzon_syndrome;Crouzon_syndrome-acanthosis_nigricans_syndrome;Curry-Hall_syndrome;Dandy-Walker_syndrome;Developmental_and_epileptic_encephalopathy,_63;Diabetes_mellitus;Diaphragmatic_eventration;Disproportionate_short-limb_short_stature;Duane_retraction_syndrome;EMM-NULL_PHENOTYPE;Ellis-van_Creveld_syndrome;Epidermal_nevus;FGFR3-related_chondrodysplasia;FGFR3-related_disorder;Facial_asymmetry;Feeding_difficulties;Femoral_bowing;Fetal_akinesia_deformation_sequence_1;Fetal_akinesia_deformation_sequence_3;Fibrous_dysplasia_of_jaw;Generalized_non-motor_(absence)_seizure;Global_developmental_delay;Growth_delay;Hamartoma;Hurler_syndrome;Hydronephrosis;Hydroureter;Hypochondroplasia;Hypoplastic_enamel-onycholysis-hypohidrosis_syndrome;Hypotonia,_ataxia,_developmental_delay,_and_tooth_enamel_defect_syndrome;Inborn_genetic_diseases;Infantile_axial_hypotonia;Intellectual_disability,_autosomal_recessive_53;Interstitial_pneumonitis;Jeune_thoracic_dystrophy;Larsen_syndrome;Leber_congenital_amaurosis;Lethal_short-limbed_short_stature;Levy-Hollister_syndrome;Lower_limb_undergrowth;Lung_adenocarcinoma;Malignant_tumor_of_testis;Malignant_tumor_of_urinary_bladder;Microglossia;Micrognathia;Mucopolysaccharidosis,_MPS-I-H/S;Mucopolysaccharidosis,_MPS-I-S;Mucopolysaccharidosis_type_1;Muenke_syndrome;Multiple_myeloma;Myopia_23,_autosomal_recessive;Narrow_chest;Neurodevelopmental_delay;Night_blindness;Nonsyndromic_genetic_hearing_loss;PDE6B-Related_Disorders;Papillary_renal_cell_carcinoma,_sporadic;Rare_genetic_deafness;Rauch-Steindl_syndrome;Retinal_dystrophy;Retinitis_pigmentosa;Retinitis_pigmentosa_40;Rett_syndrome;Rod-cone_dystrophy;SEVERE_ACHONDRODYSPLASIA_WITH_DEVELOPMENTAL_DELAY_AND_ACANTHOSIS_NIGRICANS;Saethre-Chotzen_syndrome;Seborrheic_keratosis;See_cases;Seizure;Sensorineural_hearing_loss_disorder;Severe_achondroplasia-developmental_delay-acanthosis_nigricans_syndrome;Short-rib_thoracic_dysplasia_6_with_or_without_polydactyly;Short_ribs;Short_stature;Skeletal_dysplasia;Skeletal_dysplasia_with_acanthosis_nigricans;Small_for_gestational_age;Small_hand;Smith-Magenis_Syndrome-like;Spermatocytic_seminoma;Squamous_cell_carcinoma_of_the_head_and_neck;Squamous_cell_lung_carcinoma;Syndromic_intellectual_disability;Thanatophoric_dysplasia,_type_2;Thanatophoric_dysplasia_type_1;Transitional_cell_carcinoma_of_the_bladder;Type_2_diabetes_mellitus;Type_IV_short_rib_polydactyly_syndrome;Unilateral_renal_agenesis;Upper_limb_undergrowth;Urinary_bladder_carcinoma;WFS1-Related_Spectrum_Disorders;WFS1-related_disorder;Wolf-Hirschhorn_like_syndrome;Wolfram-like_syndrome;Wolfram_syndrome;Wolfram_syndrome_1;not_specified 4:146750-146750 1000g;4:401040-401369 1000g;4:525031-525090 CMRI:3_pbsv.INS.DUP.9;4:560440-560691 CMRI:2_pbsv.SPLIT.DUP.9;4:672946-673060 gnomAD-SV_v2.1_DUP_4_10858;4:672962-673059 CMRI:1_pbsv.INS.DUP.12;4:822850-830000 gnomAD-SV_v2.1_DUP_4_10873;4:896906-897012 gnomAD-SV_v2.1_DUP_4_10878;4:920602-921305 gnomAD-SV_v2.1_DUP_4_10883;4:953000-963000 gnomAD-SV_v2.1_DUP_4_10885;4:991250-998500 gnomAD-SV_v2.1_DUP_4_10888;4:1036000-1041000 gnomAD-SV_v2.1_DUP_4_10894;4:1052008-1052100 gnomAD-SV_v2.1_DUP_4_10898;4:1141289-1141834 gnomAD-SV_v2.1_DUP_4_10902;4:1216000-1225000 gnomAD-SV_v2.1_DUP_4_10906;4:1346000-1352100 gnomAD-SV_v2.1_DUP_4_10920;4:1368000-1374500 gnomAD-SV_v2.1_DUP_4_10922;4:1391695-1392448 CMRI:195_pbsv.SPLIT.DUP.117;4:1395250-1402000 gnomAD-SV_v2.1_DUP_4_10925;4:1526023-1526223 CMRI:48_pbsv.INS.DUP.107;4:1672665-1673134 gnomAD-SV_v2.1_DUP_4_10934... 4:73133-74170 gnomAD-SV_v2.1_DUP_4_10814;4:255773-255773 1000g;4:535732-535809 gnomAD-SV_v2.1_DUP_4_10839;4:549110-549476 CMRI:6_pbsv.SPLIT.DUP.15;4:625000-630200 gnomAD-SV_v2.1_DUP_4_10851;4:673000-683050 gnomAD-SV_v2.1_DUP_4_10859;4:721539-721539 1000g;4:881239-881349 gnomAD-SV_v2.1_DUP_4_10877;4:897374-897472 gnomAD-SV_v2.1_DUP_4_10879;4:926067-926498 DDD:12703;4:970627-980630 dgv1450e212;4:1019688-1020098 gnomAD-SV_v2.1_DUP_4_10892;4:1040161-1040475 gnomAD-SV_v2.1_DUP_4_10895;4:1052006-1052098 CMRI:8_pbsv.INS.DUP.82;4:1204543-1204621 gnomAD-SV_v2.1_DUP_4_10904;4:1301834-1301834 1000g;4:1366496-1366556 gnomAD-SV_v2.1_DUP_4_10921;4:1391226-1392354 CMRI:2_pbsv.SPLIT.DUP.100;4:1391816-1392448 CMRI:47_pbsv.SPLIT.DUP.100;4:1498696-1499228 gnomAD-SV_v2.1_DUP_4_10927;4:1526023-1526281 CMRI:2_pbsv.INS.DUP.108... 4:120578-120638 CMRI:76_pbsv.DEL.0_duplicate3;4:198668-199069 gnomAD-SV_v2.1_DEL_4_41485;4:263958-264238 esv2665266;4:263958-264238 CMRI:5_pbsv.DEL.7_duplicate2;4:293176-293233 CMRI:5_pbsv.DEL.8_duplicate2;4:401040-401369 1000g;4:401040-401369 CMRI:2_pbsv.DEL.6_duplicate1;4:443957-444059 CMRI:123_pbsv.DEL.7_duplicate2;4:544458-544573 CMRI:58_pbsv.DEL.9_duplicate2;4:570691-570740 CMRI:2_pbsv.DEL.11_duplicate1;4:612317-612381 1000g;4:612317-612381 CMRI:5_pbsv.DEL.27_duplicate3;4:629177-629318 CMRI:6_pbsv.DEL.26_duplicate2;4:645477-645548 CMRI:11_pbsv.DEL.42_duplicate2;4:662285-662489 CMRI:5_pbsv.DEL.33_duplicate1;4:662722-663394 CMRI:1_pbsv.DEL.10_duplicate3;4:675385-675464 CMRI:90_pbsv.DEL.15_duplicate3;4:694767-695837 gnomAD-SV_v2.1_DEL_4_41558;4:701733-701876 CMRI:2_pbsv.DEL.18_duplicate1;4:708776-710135 esv2665221;4:708761-710027 CMRI:5_pbsv.DEL.40_duplicate1... 4:91367-96776 1000g;4:156233-158501 nsv515005;4:209407-209857 DDD:12676;4:263968-264392 gnomAD-SV_v2.1_DEL_4_41495;4:293144-293233 CMRI:0_pbsv.DEL.5_duplicate1;4:389708-389804 CMRI:4_pbsv.DEL.6_duplicate2;4:401052-401369 gnomAD-SV_v2.1_DEL_4_41508;4:443956-444059 gnomAD-SV_v2.1_DEL_4_41518;4:513461-513572 CMRI:3_pbsv.DEL.8;4:553633-553767 CMRI:5_pbsv.DEL.21_duplicate2;4:605147-605214 CMRI:1_pbsv.DEL.7_duplicate3;4:612319-612381 gnomAD-SV_v2.1_DEL_4_41537;4:628812-629275 CMRI:5_pbsv.DEL.28_duplicate4;4:645013-645062 CMRI:5_pbsv.DEL.29_duplicate2;4:663100-663586 esv2663678;4:662722-662961 CMRI:3_pbsv.DEL.18_duplicate3;4:662859-663025 CMRI:36_pbsv.DEL.13_duplicate3;4:694708-695895 1000g;4:694768-695837 DDD:12694;4:707011-707135 esv2666806;4:707011-707135 CMRI:0_pbsv.DEL.14_duplicate1... 1000244;1001499;1001513;1001514;1001518;1004662;1004669;1004693;1004750;1004754;1004779;1004780;1004781;1004782;1004783;1004786;1004787;1004788;1004794;1004801;1004807;1004817;1004821;1004822;1004823;1004825;1004832;1004835;1004836;1004840;1004841;1004855;1004860;1004864;1004867;1004872;1004876;1006269;1006984;1006992;1007019;1007027;1007030;1007031;1007033;1007036;1007038;1007043;1007044;1007046;1007047;... gain;loss 0.445 0.425 4:9370857-9371011 MER5B 4:9357712-9469143;4:9357889-9408758;4:9357889-9408758;4:9362634-9457876 4:9199301-9371400 High Signal Region 3 1.29231994213647 1.20702378077388 1.11611247300207 3.25348988684008 5.41905620095129 102680;104250;605032;602618;610285;604831;607261;134934;142992;602537;182138;613004;252800;104225;142983;610647;602952;180072;616918;612041;602104;610130;614632;606201;194648 yes yes 0 1.0000e+00 1.0000e+00 1.9 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3C (152 genes, +0.90);5F (+0.00) 5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ABCA11P NR_002451 419223 467998 48775 0 0 no 3 txStart-txEnd UTR 419223 467998 51226 loss full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 ABLIM2 NM_001130083 7967053 8160540 193487 1938 100 no 21 txStart-txEnd 5'UTR-3'UTR 7967053 8160540 1010175;1010176;1030022;1033276;1033277;1034389;1034399;1034400;1038265;160939;22003;2281227;24486;250340;311613;311614;312165;312176;312201;312239;334878;334879;340173;344716;4194;507701;582548;599925;601329;743922;743925;743926;772517;793318;858346;946073;946097;946100;946101;946104;946109;98540;99137;99271;99276 gain;loss 63.64 0.337838438332487 -0.499016330621921 -0.246989921895573 -1.59029981969928 -1.42113131036961 2 4.5858e-03 7.6242e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 ACOX3 NM_003501 8368008 8442450 74442 2103 100 no 18 txStart-txEnd 5'UTR-3'UTR 8368008 8442450 1028616;1040498;1812851;2137816 gain;loss 82.99 -2.37227679543374 -0.95101441383295 -1.44715983267575 -0.00424238497735845 -0.527819209746206 5 7.6016e-16 3.0316e-12 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ADD1 NM_001354761 2845570 2931789 86219 2400 100 no 16 txStart-txEnd 5'UTR-3'UTR 2845570 2931789 276889;418829;419175;470841 gain;loss 46.84 0.415100440885564 -0.0353582367682211 0.160620922610348 1.55687904782076 0.599493733703596 102680 (Hypertension, essential, salt-sensitive), 145500 (3) Multifactorial Multifactorial yes 1 9.8830e-01 6.1130e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ADRA2C NM_000683 3768111 3770253 2142 1389 72 no 1 txStart-txEnd 5'UTR-3'UTR 3768111 3770253 68.35 3.21047317301589 5.41905620095129 104250 (Congestive heart failure and beta-blocker response, modifier of) (3) yes 3 5.0159e-01 6.4595e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 AFAP1 NM_001134647 7760439 7941653 181214 2445 100 no 18 txStart-txEnd 5'UTR-3'UTR 7760439 7941653 1004855;1038263;1040482;11263;20869;257540;3063870;311610;324492;385542;398628;414207;4192;445352;6749;772488;772490;772491;788203;964781;984963 gain;loss 70.06 -2.62354415217069 -0.232673834093773 -1.98456571684452 -1.13990389227529 -0.987321027475765 3 2.3828e-07 3.7607e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 AFAP1-AS1 NR_026892 7755816 7780654 24838 0 0 no 2 txStart-txEnd UTR 7755816 7780654 1040482;385542;743912 gain;loss full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ATP5ME NM_007100 666224 668065 1841 210 100 no 4 txStart-txEnd 5'UTR-3'UTR 666224 668065 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 BLOC1S4 NM_018366 6717900 6719389 1489 654 45 no 1 txStart-txEnd 5'UTR-3'UTR 6717900 6719389 72.47 2.75338717063303 1.98938453238048 9 1.0151e-01 1.5897e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 C4orf48 NM_001168243 2043719 2045697 1978 387 100 no 4 txStart-txEnd 5'UTR-3'UTR 2043719 2045697 80.21 7 5.1423e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2-p16.1 C4orf50 NM_001364689 5958838 6020273 61435 4527 100 no 12 txStart-txEnd 5'UTR-3'UTR 5958838 6020273 1033260;1225807;2175936;2254058;2268610;2281038;2426862;2492568;2604601;2681934;2715789;317153;548440;592494;986743;988074 gain;loss 98.01 0.369490376960693 0.371330581311454 0.517389412359409 -2.62911053265251 -1.8079483903393 7 7.7361e-19 6.3423e-10 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 CCDC96 NM_153376 7042575 7044728 2153 1668 96 no 1 txStart-txEnd 5'UTR-3'UTR 7042575 7044728 88.85 0.393108310742818 -0.13797094617163 0.0809738518294932 3.25348988684008 1.81654247561098 8 1.9555e-17 2.7054e-06 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CFAP99 NM_001193282 2420681 2464690 44009 1941 100 no 16 txStart-txEnd 5'UTR-3'UTR 2420681 2464690 1010128;1012924;16682;216085;24429;359729;364891;5118;552442;598292 gain;loss full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CPLX1 NM_006651 778744 819917 41173 405 100 no 4 txStart-txEnd 5'UTR-3'UTR 778744 819917 Developmental and epileptic encephalopathy 63, 617976 (3) AR morbid:CPLX1 4:778745-819917 1 Developmental_and_epileptic_encephalopathy,_63 24484 gain 57.56 0.307891021887021 -0.276081088005473 -0.0592308346427654 -0.123982055433658 0.739036799993362 developmental and epileptic encephalopathy, 63;familial infantile myoclonic epilepsy AR Strong;Supportive 11163241;26539891;28422131;28422131[PMID] 605032 Developmental and epileptic encephalopathy 63, 617976 (3) AR AR yes 2 8.2499e-01 7.9579e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 CPZ NM_001014447 8594491 8621479 26988 1959 100 no 11 txStart-txEnd 5'UTR-3'UTR 8594491 8621479 105310;105731;105769;105787;772553 loss 75.68 -2.62354415217069 -1.41032367542656 -1.95519140378666 -2.6391793475309 -5.33339017829433 9 8.8063e-36 4.5080e-21 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 CRMP1 NM_001014809 5822490 5894813 72323 2061 100 no 14 txStart-txEnd 5'UTR-3'UTR 5822490 5894813 1033254;552468;743863 gain;loss 43.19 -2.45831687825306 -0.486186941840208 -1.27538361497834 0.0326224850029478 2.34696639804313 1 9.9173e-01 9.5327e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CTBP1 NM_001377186 1205232 1242918 37686 1326 100 no 9 txStart-txEnd 5'UTR-3'UTR 1205232 1242918 1 Hypotonia,_ataxia,_developmental_delay,_and_tooth_enamel_defect_syndrome;Inborn_genetic_diseases 30.46 0.372261467334061 -0.687680790971782 -0.398820302991302 -0.219318263143712 4.00265992091985 hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome AD Strong 27094857 602618 Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome, 617915 (3) AD AD yes 1 9.8442e-01 9.7976e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CTBP1-AS NR_104331 1203907 1212379 8472 0 0 no 6 txStart-txEnd UTR 1203907 1212379 1 Hypotonia,_ataxia,_developmental_delay,_and_tooth_enamel_defect_syndrome;Inborn_genetic_diseases full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CTBP1-DT NR_033339 1243227 1246795 3568 0 0 no 2 txStart-txEnd UTR 1243227 1246795 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 CYTL1 NM_018659 5016313 5021185 4872 411 100 no 4 txStart-txEnd 5'UTR-3'UTR 5016313 5021185 76.44 -0.6295570831736 0.0670299843738293 -0.200045256499347 0.45277691276168 0.0974901129923348 9 1.0733e-05 6.5277e-04 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 DGKQ NM_001347 952674 967357 14683 2829 100 no 23 txStart-txEnd 5'UTR-3'UTR 952674 967357 855622 loss 68.02 0.720690705407562 -0.962987167732907 -0.540807434627598 -0.885541042446365 0.113301977907898 3 1.7603e-09 1.1940e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 DOK7 NM_001301071 3465032 3503209 38177 1827 100 no 10 txStart-txEnd 5'UTR-3'UTR 3465032 3503209 Fetal akinesia deformation sequence 3, 618389 (3) AR;Myasthenic syndrome, congenital, 10, 254300 (3) AR dbVar:nssv15130945;dbVar:nssv15131476;dbVar:nssv15770186;dbVar:nssv16213451;dbVar:nssv16214333;dbVar:nssv17971686;dbVar:nssv17972166;morbid:DOK7 4:3465094-3495238;4:3465104-3465298;4:3475114-3491543;4:3486271-3496209;4:3487104-3487370;4:3487247-3495248;4:3487257-3487395;4:3487257-3495238 36 Abnormality_of_the_musculature;Congenital_myasthenic_syndrome;Congenital_myasthenic_syndrome_10;Fetal_akinesia_deformation_sequence_1;Fetal_akinesia_deformation_sequence_3;Inborn_genetic_diseases;Rett_syndrome;See_cases 1008804;1033209;1033210;1064617;134562;135534;136245;21990;21991;26112;32348;32581;332618;344702;344987;358558;358710;368870;380623;380690;380693;380694;383792;384043;393878;393879;4167;537618 gain;loss 30 75.35 -2.68253992069213 -3.72411383897722 congenital myasthenic syndrome 10;fetal akinesia deformation sequence 1;fetal akinesia deformation sequence 3;postsynaptic congenital myasthenic syndrome AR Definitive;Limited;Strong;Supportive 16794080;16917026;18626973;19261599[PMID];20147321;20301347[PMID];29395672;31453852;32360404 610285 Fetal akinesia deformation sequence 3, 618389 (3) AR;Myasthenic syndrome, congenital, 10, 254300 (3) AR AR yes 5 1.0263e-04 4.8084e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 EVC NM_153717 5712927 5816032 103105 2979 100 no 21 txStart-txEnd 5'UTR-3'UTR 5712927 5816032 dbVar:nssv17172169 4:5785270-5803831 ?Weyers acrofacial dysostosis, 193530 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR;Curry-Hall_syndrome|Ellis-van_Creveld_syndrome CLN:1313135;dbVar:nssv15144315;dbVar:nssv16211870;dbVar:nssv16297131;dbVar:nssv17172168;dbVar:nssv17172572;dbVar:nssv17172573;dbVar:nssv17172574;dbVar:nssv17971734;dbVar:nssv17973718;nssv17974037;dbVar:nssv17975024;morbid:EVC 4:5712928-5816032;4:5731025-5759862;4:5733143-5735172;4:5749726-5755670;4:5754554-5755670;4:5754599-5758602;4:5795340-5795484;4:5795341-5795483;4:5798730-5798979;4:5798740-5798969;4:5803668-5806578;4:5809919-5811348 91 Curry-Hall_syndrome;Ellis-van_Creveld_syndrome;Short-rib_thoracic_dysplasia_6_with_or_without_polydactyly 1995043;2776114;347080;592487;649544;649545;649546;652298;653456;657724;673787;679097;684495;685609;690031;690677;698699;772308;772309;772310;772311;772312;853431;853433;966873 gain;loss 72.76 -2.57221447207538 -0.38737545040403 -1.26125942639438 -0.471176482163648 -1.41925515956187 Ellis-van Creveld syndrome;acrofacial dysostosis, Weyers type AD;AR Definitive;Strong;Supportive 10700184;10700184[PMID];12468274;12571802;14217223;17024374;21815252;23220543;23220543[PMID]_22791528[PMID]_19744229[PMID]_18947413[PMID];26748586;7218275;7628126 604831 ?Weyers acrofacial dysostosis, 193530 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR AD;AR yes yes 5 3.4620e-25 8.0150e-08 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 EVC2 NM_147127 5564165 5710286 146121 3927 100 no 22 txStart-txEnd 5'UTR-3'UTR 5564165 5710286 dbVar:nssv17973849 4:5567009-5587839 Ellis-van Creveld syndrome, 225500 (3) AR;Weyers acrofacial dysostosis, 193530 (3) AD dbVar:nssv15770321;dbVar:nssv16213046;dbVar:nssv16213271;dbVar:nssv16297119;dbVar:nssv17172955;dbVar:nssv17971266;dbVar:nssv17971361;dbVar:nssv17972056;morbid:EVC2 4:5564166-5710286;4:5564566-5586587;4:5564576-5567096;4:5570162-5570377;4:5630277-5633769;4:5630338-5635927;4:5642222-5642585;4:5690875-5691080;4:5696053-5696238 107 Curry-Hall_syndrome;Ellis-van_Creveld_syndrome;Inborn_genetic_diseases;Jeune_thoracic_dystrophy;Short-rib_thoracic_dysplasia_6_with_or_without_polydactyly;Type_IV_short_rib_polydactyly_syndrome;not_specified 1033245;1033246;1034393;1034400;1064620;1118405;1881710;229014;230363;264146;2882000;2912386;291667;414192;415320;674543;795819;853422;96040 gain;loss 30 0 74.81 -0.675336787286134 -0.144705826949755 -0.333473000003108 -1.44193705805358 -2.99791740003004 Ellis-van Creveld syndrome;acrofacial dysostosis, Weyers type AD;AR Definitive;Strong;Supportive 16404586;17024374;17547743;19810119;19876929;225500;22616035;23220543;23220543[PMID]_22791528[PMID]_12571802[PMID]_12468274[PMID];23220543[PMID]_22791528[PMID]_16404586[PMID] 607261 Ellis-van Creveld syndrome, 225500 (3) AR;Weyers acrofacial dysostosis, 193530 (3) AD AD;AR yes 5 1.0207e-34 1.0533e-21 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FAM193A NM_001366318 2538373 2734300 195927 4548 100 no 21 txStart-txEnd 5'UTR-3'UTR 2538373 2734300 1010130;1034912;1079445;1144241;338961;343190;343797;343815;368037;414144;771821;771822;771825;771826 gain;loss 63.75 0.047435784931723 0.578303279433319 0.446297134803958 -0.738211104213101 1.24551033534962 0 9.9993e-01 9.9782e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FAM53A NM_001174070 1641607 1686040 44433 1197 100 no 5 txStart-txEnd 5'UTR-3'UTR 1641607 1686040 336174;336489 loss 86.49 -0.576730190868019 -0.56780381579822 6 3.5705e-03 3.0070e-05 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FAM86EP NR_130740 3943486 3957155 13669 0 0 no 4 txStart-txEnd UTR 3943486 3957155 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 FAM90A26 NM_001358418 9174898 9177893 2995 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 9174898 9177893 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174;gnomAD-SV_v2.1_DUP_4_11182 4:9099000-9212000;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 1000g;DDD:12912;DDD:12915;dgv923e199;esv3599566 4:9157569-9214307;4:9157569-9214307;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 98.14 9 2.8656e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FGFR3 NM_001163213 1795038 1810599 15561 2427 100 no 18 txStart-txEnd 5'UTR-3'UTR 1795038 1810599 Achondroplasia, 100800 (3) AD;Bladder cancer, somatic, 109800 (3);CATSHL syndrome, 610474 (3) AR,AD;Cervical cancer, somatic, 603956 (3);Colorectal cancer, somatic, 114500 (3);Crouzon syndrome with acanthosis nigricans, 612247 (3) AD;Hypochondroplasia, 146000 (3) AD;LADD syndrome, 149730 (3) AD;Muenke syndrome, 602849 (3) AD;Nevus, epidermal, somatic, 162900 (3);SADDAN, 616482 (3) AD;Spermatocytic seminoma, somatic, 273300 (3);Thanatophoric dysplasia, type I, 187600 (3) AD;Thanatophoric dysplasia, type II, 187601 (3) AD morbid:FGFR3 4:1795039-1810599 29 Abnormality_of_the_nervous_system;Achondroplasia;Bell-shaped_thorax;Bowed_humerus;Camptodactyly-tall_stature-scoliosis-hearing_loss_syndrome;Cancer_of_cervix;Carcinoma;Carcinoma_of_colon;Connective_tissue_disorder;Coronal_craniosynostosis;Craniosynostosis_syndrome;Crouzon_syndrome;Crouzon_syndrome-acanthosis_nigricans_syndrome;Disproportionate_short-limb_short_stature;Epidermal_nevus;FGFR3-related_chondrodysplasia;FGFR3-related_disorder;Facial_asymmetry;Femoral_bowing;Generalized_non-motor_(absence)_seizure;Growth_delay;Hamartoma;Hypochondroplasia;Inborn_genetic_diseases;Infantile_axial_hypotonia;Larsen_syndrome;Lethal_short-limbed_short_stature;Levy-Hollister_syndrome;Lower_limb_undergrowth;Lung_adenocarcinoma;Malignant_tumor_of_testis;Malignant_tumor_of_urinary_bladder;Muenke_syndrome;Multiple_myeloma;Narrow_chest;Neurodevelopmental_delay;Papillary_renal_cell_carcinoma,_sporadic;SEVERE_ACHONDRODYSPLASIA_WITH_DEVELOPMENTAL_DELAY_AND_ACANTHOSIS_NIGRICANS;Saethre-Chotzen_syndrome;Seborrheic_keratosis;Seizure;Severe_achondroplasia-developmental_delay-acanthosis_nigricans_syndrome;Short_ribs;Short_stature;Skeletal_dysplasia;Skeletal_dysplasia_with_acanthosis_nigricans;Small_for_gestational_age;Spermatocytic_seminoma;Squamous_cell_carcinoma_of_the_head_and_neck;Squamous_cell_lung_carcinoma;Thanatophoric_dysplasia,_type_2;Thanatophoric_dysplasia_type_1;Transitional_cell_carcinoma_of_the_bladder;Unilateral_renal_agenesis;Upper_limb_undergrowth;Urinary_bladder_carcinoma;not_specified 393816;393817;395197 loss 0 0 6.4 -0.683349552436101 -0.392116289350703 -0.538573860699497 -2.22163439002498 1.36559781959522 Crouzon syndrome-acanthosis nigricans syndrome;LADD syndrome;Muenke syndrome;achondroplasia;camptodactyly-tall stature-scoliosis-hearing loss syndrome;hypochondroplasia;isolated brachycephaly;isolated plagiocephaly;severe achondroplasia-developmental delay-acanthosis nigricans syndrome;thanatophoric dysplasia type 1;thanatophoric dysplasia type 2 AD;AR Definitive;Moderate;Strong;Supportive 10053006[PMID]_18076102[PMID];10215410;10914960[PMID];11055896;16411219;16501574;16501574[PMID];16912704;17033969;17033969[PMID]_24864036[PMID];19449430;20301540[PMID];20301588[PMID]_20301628[PMID]_21438135[PMID];20301628[PMID];20301650[PMID]_23149434[PMID];23149434[PMID];27139183;28483234;7493034;7647778;7670477;7758520;7773297;7913883;8078586;8589686;8845844;9452043 134934 Achondroplasia, 100800 (3) AD;Bladder cancer, somatic, 109800 (3);CATSHL syndrome, 610474 (3) AR,AD;Cervical cancer, somatic, 603956 (3);Colorectal cancer, somatic, 114500 (3);Crouzon syndrome with acanthosis nigricans, 612247 (3) AD;Hypochondroplasia, 146000 (3) AD;LADD syndrome, 149730 (3) AD;Muenke syndrome, 602849 (3) AD;Nevus, epidermal, somatic, 162900 (3);SADDAN, 616482 (3) AD;Spermatocytic seminoma, somatic, 273300 (3);Thanatophoric dysplasia, type I, 187600 (3) AD;Thanatophoric dysplasia, type II, 187601 (3) AD AD;AR,AD yes 3 1.6432e-05 2.9091e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FGFRL1 NM_001004356 1005413 1020686 15273 1515 100 no 7 txStart-txEnd 5'UTR-3'UTR 1005413 1020686 0 0 61.34 0.15762668797229 -0.095835364724166 0.0269779205648351 -1.06125182633592 -0.304110728864919 3 1.1908e-02 5.8219e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 GAK NM_005255 843064 926104 83040 3936 100 no 28 txStart-txEnd 5'UTR-3'UTR 843064 926104 304632;304633 loss 66.55 1.00920516918233 -1.32268830826731 -0.753758448502777 -1.09712093422474 -0.06853474623291 1 5.1818e-03 9.7313e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 GPR78 NM_080819 8582118 8591750 9632 1092 100 no 3 txStart-txEnd 5'UTR-3'UTR 8582118 8591750 277176 loss 91.64 -2.62354415217069 -1.33186842996177 -1.94147419136763 -0.663631774481401 -1.44235869751468 9 2.6834e-06 1.2826e-05 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 GRK4 NM_182982 2965297 3042487 77190 1737 100 no 16 txStart-txEnd 5'UTR-3'UTR 2965297 3042487 1792169;2543710;2744065;771860;946197;946225;998224;998290;998291 gain;loss 77.79 -1.99297870008351 -1.29609278714656 -1.46605851541056 -0.226834639209249 -0.865456519909477 6 1.6286e-15 5.6904e-07 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 GRPEL1 NM_025196 7060621 7069791 9170 654 100 no 4 txStart-txEnd 5'UTR-3'UTR 7060621 7069791 50.3 0.649976625334672 -1.27240513662323 -0.777477966060391 0.934834224809331 0.303907421223287 4 1.3916e-01 8.9627e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HAUS3 NM_001303143 2230093 2243848 13755 1812 100 no 6 txStart-txEnd 5'UTR-3'UTR 2230093 2243848 46.58 0.701548607121356 -0.365908352795815 0.0332648069020548 -0.527208917402428 -2.11601983727089 6 1.2992e-09 8.8992e-07 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HGFAC NM_001297439 3443694 3451213 7519 1989 100 no 15 txStart-txEnd 5'UTR-3'UTR 3443694 3451213 11233;135533;337939;346109;363961;379302;598304;601309 gain;loss 76.94 -2.62354415217069 0.291115018050139 -2.47162789907313 -2.1421417021426 -1.44878648893363 4 1.9843e-08 5.2082e-07 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 HMX1 NM_018942 8868773 8873565 4792 1047 100 no 2 txStart-txEnd 5'UTR-3'UTR 8868773 8873565 Oculoauricular syndrome, 612109 (3) AR morbid:HMX1 4:8868774-8873565 66.38 1.46868520416757 1.8176765127262 oculoauricular syndrome AR Definitive;Strong;Supportive 18423520;18423520[PMID]_25574057[PMID];25574057;29140751 142992 Oculoauricular syndrome, 612109 (3) AR AR yes 3 7.2623e-01 1.2528e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 HTRA3 NM_053044 8271480 8308825 37345 1362 100 no 9 txStart-txEnd 5'UTR-3'UTR 8271480 8308825 Vitreoretinopathy, neovascular inflammatory, 193235 (3) AD morbid:HTRA3 4:8271481-8308825 414213;414674;772523 gain;loss 70.02 -0.536935947037787 -0.623131034083341 -0.644700690991608 0.667359866413857 1.21754776737995 602537 Vitreoretinopathy, neovascular inflammatory, 193235 (3) AD AD yes 6 6.5843e-08 1.7199e-05 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HTT NM_002111 3076407 3245687 169280 9429 100 no 67 txStart-txEnd 5'UTR-3'UTR 3076407 3245687 Huntington disease, 143100 (3) AD;Lopes-Maciel-Rodan syndrome, 617435 (3) AR;Anxiety-related personality traits, 607834 (3);Obsessive-compulsive disorder, 164230 (3) AD morbid:HTT 4:3076408-3245687 1004794;2246285;298835;414150;454017;557895;743796;743797;743798;752640;771871;771875;771876;900268 gain;loss 7.59 -0.672019089975884 1.20702378077388 0.455761090475751 -0.292338464564844 2.75557960790302 Huntington disease;Lopes-Maciel-Rodan syndrome;juvenile Huntington disease AD;AR Definitive;Limited;Strong;Supportive 11264541;17181545[PMID];20301482[PMID]_21566141[PMID];8401587;8458085 182138;613004 Huntington disease, 143100 (3) AD;Lopes-Maciel-Rodan syndrome, 617435 (3) AR;(Anxiety-related personality traits), 607834 (3);(Obsessive-compulsive disorder), 164230 (3) AD AD;AR yes yes 0 1.0000e+00 1.0000e+00 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HTT-AS NR_045414 3064972 3076241 11269 0 0 no 3 txStart-txEnd UTR 3064972 3076241 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 IDUA NM_000203 980831 998352 17521 1962 100 no 14 txStart-txEnd 5'UTR-3'UTR 980831 998352 Mucopolysaccharidosis Ih, 607014 (3) AR;Mucopolysaccharidosis Ih;s, 607015 (3) AR;Mucopolysaccharidosis Is, 607016 (3) AR;Mucopolysaccharidosis_type_1 CLN:961843;dbVar:nssv16216714;morbid:IDUA 4:993498-998345;4:996510-998192;4:996511-998191 146 Hurler_syndrome;Inborn_genetic_diseases;Interstitial_pneumonitis;Mucopolysaccharidosis,_MPS-I-H/S;Mucopolysaccharidosis,_MPS-I-S;Mucopolysaccharidosis_type_1;See_cases 772749 loss 30 69.73 -1.6058292542185 -1.19882139820352 -1.40825779214199 -0.0473365386141676 0.337473103766752 Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;mucopolysaccharidosis type 1 AR Definitive;Strong;Supportive 10466419;10735634;23917744;4221470;6821579;7550232;7951228;8328452;8664897;8680403[PMID];9391892 252800 Mucopolysaccharidosis Ih, 607014 (3) AR;Mucopolysaccharidosis Ih/s, 607015 (3) AR;Mucopolysaccharidosis Is, 607016 (3) AR AR yes 6 3.7599e-13 2.6418e-08 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 JAKMIP1 NM_001099433 6027925 6202276 174351 2496 100 no 21 txStart-txEnd 5'UTR-3'UTR 6027925 6202276 1 Smith-Magenis_Syndrome-like 1035829;1035831;147065;220016;220324;220329;220345;220347;220358;277014;393934;393935;393936;393937;472833;778397;853446;853449;939223 gain;loss 52.99 0.975078008148592 0.865866943304307 1.11611247300207 0.172471674763915 3.32151835531883 0 9.9986e-01 9.9317e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 KIAA0232 NM_001100590 6784458 6885899 101441 4188 100 no 9 txStart-txEnd 5'UTR-3'UTR 6784458 6885899 1059219;1059518;1071711;264160;298845 gain;loss 62.19 0.495223937339359 -0.201270287076057 0.0915777485634488 -1.04317795810088 0.185259378880778 0 9.9999e-01 9.9472e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LETM1 NM_012318 1813205 1857883 44678 2220 100 no 14 txStart-txEnd 5'UTR-3'UTR 1813205 1857883 0 0 63.78 0.214548231055587 -0.175454101774909 -0.0279109913872425 -1.46983950545222 1.90036967420169 3 1.2141e-06 8.1055e-02 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LINC00955 NR_040045 3578595 3592712 14117 0 0 no 3 txStart-txEnd UTR 3578595 3592712 1024419;649536;651650;654469;675129;677165;703590 gain;loss 93.6 8 4.5772e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LINC01396 NR_125765 4846163 4852554 6391 0 0 no 4 txStart-txEnd UTR 4846163 4852554 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LINC01587 NR_126519 5526295 5529527 3232 0 0 no 4 txStart-txEnd UTR 5526295 5529527 96.4 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LINC02171 NR_034136 3675319 3679582 4263 0 0 no 3 txStart-txEnd UTR 3675319 3679582 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02447 NR_027441 7099150 7105103 5953 0 0 no 2 txStart-txEnd UTR 7099150 7105103 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02481 NR_147207 6689174 6692246 3072 0 0 no 3 txStart-txEnd UTR 6689174 6692246 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02482 NR_134664 6672454 6675608 3154 0 0 no 2 txStart-txEnd UTR 6672454 6675608 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02495 NR_037863 6202459 6235663 33204 0 0 no 4 txStart-txEnd UTR 6202459 6235663 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02517 NR_149125 8321902 8325692 3790 0 0 no 4 txStart-txEnd UTR 8321902 8325692 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC100129917 NR_036511 773936 775636 1700 0 0 no 1 txStart-txEnd UTR 773936 775636 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LOC100129931 NR_033828 7032280 7047958 15678 0 0 no 4 txStart-txEnd UTR 7032280 7047958 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC100130872 NR_024569 1189570 1202750 13180 0 0 no 4 txStart-txEnd UTR 1189570 1202750 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LOC101928279 NR_125892 4763486 4789101 25615 0 0 no 3 txStart-txEnd UTR 4763486 4789101 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LOC101928306 NR_125893 4922534 4990398 67864 0 0 no 3 txStart-txEnd UTR 4922534 4990398 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC105374338 NR_148199 570956 578655 7699 0 0 no 3 txStart-txEnd UTR 570956 578655 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC105374344 NR_134676 1107426 1126763 19337 0 0 no 3 txStart-txEnd UTR 1107426 1126763 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LOC389199 NM_203423 7940727 7942023 1296 816 72 no 1 txStart-txEnd 5'UTR-3'UTR 7940727 7942023 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LOC93622 NR_015433 6675801 6677774 1973 0 0 no 2 txStart-txEnd UTR 6675801 6677774 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LRPAP1 NM_002337 3505338 3534149 28811 1074 100 no 8 txStart-txEnd 5'UTR-3'UTR 3505338 3534149 Myopia 23, AR, 615431 (3) AR morbid:LRPAP1 4:3505339-3534149 1 Myopia_23,_autosomal_recessive 393882;393883 loss 30 81.97 -0.901439467568047 -1.0008332959639 -1.03424805406881 -0.233147203181143 -1.38131789177637 myopia 23, autosomal recessive AR Limited;Strong 23830514;25525168 104225 Myopia 23, AR, 615431 (3) AR AR yes 6 4.4951e-07 6.0843e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LYAR NM_017816 4269428 4291881 22453 1140 100 no 10 txStart-txEnd 5'UTR-3'UTR 4269428 4291881 65.63 -1.04982790537607 0.837810587333259 0.0401032398207032 0.075048187998812 -0.816993645198656 5 3.7580e-07 1.3245e-04 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MAEA NM_001017405 1283678 1333925 50247 1191 100 no 9 txStart-txEnd 5'UTR-3'UTR 1283678 1333925 1071688;517272 gain 7.13 0.506320833777115 -1.33825481458672 -0.894129278429717 -0.194585519191658 3.59552380294204 2 2.2741e-01 8.4486e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MAN2B2 NM_015274 6576915 6625075 48160 3030 100 no 19 txStart-txEnd 5'UTR-3'UTR 6576915 6625075 224062;224313;289114;302039;311602;322698;472835 gain;loss 83.66 -1.20308868163847 -0.039423685654856 -0.514512683951566 0.311204487601666 -0.733522379663636 5 6.5570e-23 4.3573e-18 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MFSD10 NM_001146069 2932293 2936552 4259 1368 100 no 13 txStart-txEnd 5'UTR-3'UTR 2932293 2936552 74.85 0.411355639726539 0.128499204561582 0.297239579860913 -3.22135273058939 -2.0505953640051 7 7.3331e-11 3.0178e-07 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 MIR378D1 NR_039608 5925001 5925055 54 0 0 no 1 txStart-txEnd UTR 5925001 5925055 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MIR4274 NR_036238 7461754 7461845 91 0 0 no 1 txStart-txEnd UTR 7461754 7461845 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MIR4798 NR_039961 7312176 7312251 75 0 0 no 1 txStart-txEnd UTR 7312176 7312251 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MIR4800 NR_039964 2251803 2251883 80 0 0 no 1 txStart-txEnd UTR 2251803 2251883 gnomAD-SV_v2.1_DUP_4_10955 4:2248000-2255000 0.0714 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MIR571 NR_030297 343945 344041 96 0 0 no 1 txStart-txEnd UTR 343945 344041 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MIR943 NR_030641 1988110 1988204 94 0 0 no 1 txStart-txEnd UTR 1988110 1988204 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MIR95 NR_029511 8007027 8007108 81 0 0 no 1 txStart-txEnd UTR 8007027 8007108 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MRFAP1 NM_001272053 6641817 6644470 2653 384 96 no 3 txStart-txEnd 5'UTR-3'UTR 6641817 6644470 78.84 0.686792213866423 0.236901723651345 0.49521306481059 0.837271434822507 2.12628699887071 6 3.1404e-01 1.7706e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MRFAP1L1 NM_203462 6709428 6711592 2164 384 61 no 2 txStart-txEnd 5'UTR-3'UTR 6709428 6711592 84.97 0.629248196007981 0.195831367621135 0.447874019110796 1.72296511806951 0.620681882628763 8 2.5481e-03 8.9080e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MSANTD1 NM_001042690 3250885 3258340 7455 837 100 no 3 txStart-txEnd 5'UTR-3'UTR 3250885 3258340 771893 loss 38.82 0.0606051954062481 0.881143579184346 2 8.0456e-01 3.2217e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 MSX1 NM_002448 4861391 4865660 4269 912 100 no 2 txStart-txEnd 5'UTR-3'UTR 4861391 4865660 Ectodermal dysplasia 3, Witkop type, 189500 (3) AD;Orofacial cleft 5, 608874 (3) AD;Tooth agenesis, selective, 1, with or without orofacial cleft, 106600 (3) AD morbid:MSX1 4:4861392-4865660 4 Hypoplastic_enamel-onycholysis-hypohidrosis_syndrome 3 0 1.21 0.15460042661567 0.172845644735031 0.256065903692486 1.56448356794936 2.50372489686823 orofacial cleft 5;tooth agenesis;tooth and nail syndrome AD Definitive;Supportive 11369996[PMID];12807959;15354328;NULL 142983 Ectodermal dysplasia 3, Witkop type, 189500 (3) AD;Orofacial cleft 5, 608874 (3) AD;Tooth agenesis, selective, 1, with or without orofacial cleft, 106600 (3) AD AD yes 5 1.6517e-01 2.7536e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MXD4 NM_006454 2249158 2263836 14678 630 100 no 6 txStart-txEnd 5'UTR-3'UTR 2249158 2263836 51.38 0.152551047660427 -0.352633837012323 -0.186392860565083 -0.362920265024982 1.29214097300775 2 7.7635e-01 8.9694e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MYL5 NM_002477 671710 675817 4107 522 100 no 7 txStart-txEnd 5'UTR-3'UTR 671710 675817 77.92 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.841325117744977 -1.07172517579562 9 8.4023e-14 4.4299e-08 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NAT8L NM_178557 2061053 2070816 9763 909 100 no 3 txStart-txEnd 5'UTR-3'UTR 2061053 2070816 gnomAD-SV_v2.1_DUP_4_10952 4:2060725-2076000 0.0200 30 0 40.87 0.098456637925367 0.547035422647778 0.555421231184509 -0.17378562567541 2.72200675038499 N-acetylaspartate deficiency AR Limited 610647 ?N-acetylaspartate deficiency, 614063 (3) AR AR yes 2 8.6458e-01 3.2468e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NELFA NM_005663 1984450 2010701 26251 1587 100 no 11 txStart-txEnd 5'UTR-3'UTR 1984450 2010701 430475 gain 0 0 62.86 0.0789021097033232 0.586448065563417 0.486612084123194 -0.704500724266535 2.35326609523799 2 1.3469e-01 1.6689e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NKX1-1 NM_001290079 1396719 1400230 3511 1347 100 no 2 txStart-txEnd 5'UTR-3'UTR 1396719 1400230 gnomAD-SV_v2.1_DUP_4_10925 4:1395250-1402000 0.0110 gnomAD-SV_v2.1_DEL_4_41642 4:1396000-1402000 0.0104 80.2 2.60422559153241 2.66896012411798 3 7.1465e-01 1.8842e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NOP14 NM_001291978 2939663 2965133 25470 2574 100 no 18 txStart-txEnd 5'UTR-3'UTR 2939663 2965133 76.1 -0.287444310372334 -1.08649031284551 2 2.1363e-06 1.7449e-02 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NOP14-AS1 NR_015453 2937272 2952800 15528 0 0 no 4 txStart-txEnd UTR 2937272 2952800 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NSD2 NM_001042424 1873119 1983919 110800 4098 100 no 22 txStart-txEnd 5'UTR-3'UTR 1873119 1983919 Rauch-Steindl syndrome, 619695 (3) AD morbid:NSD2 4:1902353-1950545 17 4p_partial_monosomy_syndrome;Global_developmental_delay;Inborn_genetic_diseases;Neurodevelopmental_delay;Rauch-Steindl_syndrome;Syndromic_intellectual_disability;Wolf-Hirschhorn_like_syndrome 264093;393850;393851;395144;395188;621015;743764;743765;743766;743767 gain;loss Wolf-Hirschhorn syndrome AD Definitive 19483677;29760529;29892088;31171569;9618163 602952 Rauch-Steindl syndrome, 619695 (3) AD AD yes full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NSG1 NM_001382227 4388828 4420785 31957 585 100 no 6 txStart-txEnd 5'UTR-3'UTR 4388828 4420785 547721 loss -0.025549754331335 0.153242929586267 0.138678963648336 0.898629456776545 -0.214997258794035 7 8.8286e-03 4.5383e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 OTOP1 NM_177998 4190453 4228656 38203 1839 100 no 6 txStart-txEnd 5'UTR-3'UTR 4190453 4228656 1690047;2487622;697250;726723;772056 gain;loss 80.7 0.337011959699387 0.333342940376347 0.48201697995522 0.532976598896309 -0.342636515952079 9 4.8437e-24 7.3147e-16 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PCGF3 NM_001317836 699620 764768 65148 729 100 no 12 txStart-txEnd 5'UTR-3'UTR 699620 764768 825062 gain 41.81 1.08104400698142 0.21167380707342 0.50450224433182 -1.15521787576548 2.22110482517757 1 9.5326e-01 9.4340e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PDE6B NM_000283 619361 664571 45210 2565 100 no 22 txStart-txEnd 5'UTR-3'UTR 619361 664571 Retinitis_pigmentosa|Retinitis_pigmentosa_40 HP:0000547 CLN:801370;dbVar:nssv15161020 4:619584-619584;4:619590-619662 Night blindness, congenital stationary, AD 2, 163500 (3) AD;Retinitis pigmentosa-40, 613801 (3) AR dbVar:nssv16213637;dbVar:nssv17171376;dbVar:nssv17171923;morbid:PDE6B 4:619417-619883;4:646966-664571;4:647642-648677;4:652722-656427 60 Autosomal_recessive_retinitis_pigmentosa;Cone-rod_dystrophy;Congenital_stationary_night_blindness_autosomal_dominant_2;Leber_congenital_amaurosis;PDE6B-Related_Disorders;Retinal_dystrophy;Retinitis_pigmentosa;Retinitis_pigmentosa_40;Rod-cone_dystrophy 393944;393945 loss 31.26 -1.62508422066579 -0.147567114346182 -0.732640703348332 -0.18186725937295 -0.360251650665831 congenital stationary night blindness;congenital stationary night blindness autosomal dominant 2;retinitis pigmentosa;retinitis pigmentosa 40 AD;AR Definitive;Strong;Supportive 12641462;17044014;19578023;20301590[PMID];22334370;22968130;24265693;24760071;24938718;25472526;26667666;28559085;30646425;8075643;8075643[PMID];8394174;8595886 180072 Night blindness, congenital stationary, AD 2, 163500 (3) AD;Retinitis pigmentosa-40, 613801 (3) AR AD;AR yes 6 2.6155e-27 1.6257e-13 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PIGG NM_001127178 492998 533989 40991 2952 100 no 13 txStart-txEnd 5'UTR-3'UTR 492998 533989 Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy, 616917 (3) AR;Blood group, EMM system, 619812 (3) AR dbVar:nssv17683620;dbVar:nssv17974578;dbVar:nssv17976464;dbVar:nssv17976477;morbid:PIGG 4:492999-533989;4:493969-499930;4:499508-502759;4:502599-509994;4:512203-518547 33 EMM-NULL_PHENOTYPE;Intellectual_disability,_autosomal_recessive_53 1627399;2851446;376537;395809;772251 gain;loss 73.18 0.208571775574472 -1.00399823985698 -0.667367098831187 1.49327706340249 -0.0905757042419409 intellectual disability, autosomal recessive 53 AR Strong 26996948 616918 Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy, 616917 (3) AR;[Blood group, EMM system], 619812 (3) AR AR yes 5 5.4258e-15 8.7751e-07 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 POLN NM_181808 2073644 2243848 170204 2703 100 no 26 txStart-txEnd 5'UTR-3'UTR 2073644 2243848 1750572;264094;264095;276854;276858;502048;517288;595645;709331 gain;loss 74.11 1.28008098953073 -0.213680271829885 0.298427608261686 0.0230368692484615 -1.08931776314455 7 9.4880e-41 2.9966e-32 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 PPP2R2C NM_020416 6322310 6474341 152031 1344 100 no 9 txStart-txEnd 5'UTR-3'UTR 6322310 6474341 1004835;1027612;1027613;1027638;195136;195737;195780;20850;250336;26138;277029;28306;311600;320366;373837;416592;416593;422017;434816;448916;460364;547730;547731;592497;74069;772379;772380;772381;772386;772387;772388;807978;840298;869945;93866;97607 gain;loss 50.29 0.338434929038259 0.422718688109719 0.476236130280707 -0.54023780146542 4.10111380803453 1 8.9954e-01 5.6445e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 PSAPL1 NM_001085382 7432011 7436657 4646 1566 96 no 1 txStart-txEnd 5'UTR-3'UTR 7432011 7436657 122148;196395;295197;79107 loss 96.06 -0.246463271906552 -0.572766431683099 -0.498050358907741 -1.4518704411588 -1.9222533414192 3.3350e-11 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 RGS12 NM_198229 3315873 3441640 125767 4344 100 no 18 txStart-txEnd 5'UTR-3'UTR 3315873 3441640 1431112;163919;1891532;276898;337104;337381;337392;383093;4164;487963;771917;771918;771931;771932;771933;807960;837508;964780 gain;loss 76.68 0.764664139864726 0.714317785060336 0.923141277111761 -0.25533666429365 0.674471945471649 3 4.0922e-09 5.6037e-04 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 RNF212 NM_001131034 1065265 1107352 42087 894 100 no 10 txStart-txEnd 5'UTR-3'UTR 1065265 1107352 ?Spermatogenic failure 62, 619673 (3) AR;Recombination rate QTL 1, 612042 (3) morbid:RNF212 4:1087097-1107352 1147378;1923747;2046676;263967;2644075;2658712;276362;3054775;795738;955619 gain;loss 88.48 -1.10887487197032 -0.266612828851805 -0.582493556461374 0.70441463212366 -0.142173437306223 612041 ?Spermatogenic failure 62, 619673 (3) AR;Recombination rate QTL 1, 612042 (3) AR yes yes 4 1.5645e-03 1.2523e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 RNF4 NM_002938 2470832 2517583 46751 573 100 no 8 txStart-txEnd 5'UTR-3'UTR 2470832 2517583 329644 gain 46.49 0.675314441657105 -0.278968200252929 0.0738937137831485 0.142993789011855 1.01071894719792 2 7.9973e-01 6.2895e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 S100P NM_005980 6695604 6698897 3293 288 100 no 2 txStart-txEnd 5'UTR-3'UTR 6695604 6698897 89.8 -0.0213485169134644 -0.684657921159283 -0.478383965590741 0.251281715605183 -0.615839346409602 9 3.3257e-02 4.8649e-02 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SCARNA22 NR_003004 1976362 1976487 125 0 0 no 1 txStart-txEnd UTR 1976362 1976487 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SH3BP2 NM_001145856 2819896 2842823 22927 1857 100 no 13 txStart-txEnd 5'UTR-3'UTR 2819896 2842823 Cherubism, 118400 (3) AD morbid:SH3BP2 4:2820541-2842823 6 Fibrous_dysplasia_of_jaw 1004787;21987;379301;399644;399775;399782;399789;415279;7989 gain;loss 63.94 0.0147924168443993 -0.755069155443864 -0.557230884715189 -0.774788091773142 0.0928341710725898 cherubism AD Limited;Strong;Supportive 11381256;22153076;22640988;NULL 602104 Cherubism, 118400 (3) AD AD yes 6 1.1560e-11 3.1019e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 SH3TC1 NM_018986 8201016 8242830 41814 4011 100 no 18 txStart-txEnd 5'UTR-3'UTR 8201016 8242830 1012930;1013744;1013904;1013914;1013932;118350;13870;22833;22834;291676;320384;329674;358565;359767;427997;577741;580198;78131;78439 gain;loss 89.77 -0.370323251116391 -0.462112374732113 -0.471672769326771 -2.08522134689875 -3.42040819381878 7 6.0939e-35 1.0820e-27 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SLBP NM_006527 1694457 1714046 19589 813 100 no 8 txStart-txEnd 5'UTR-3'UTR 1694457 1714046 41.08 -0.996144409589105 -0.44060461568473 -0.660904930034766 -0.443208130978936 0.50373477013136 4 6.8148e-02 5.1566e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SLC26A1 NM_022042 981444 987192 5748 2106 100 no 3 txStart-txEnd 5'UTR-3'UTR 981444 987192 15 Hurler_syndrome;Interstitial_pneumonitis;Mucopolysaccharidosis,_MPS-I-H/S;Mucopolysaccharidosis,_MPS-I-S;Mucopolysaccharidosis_type_1 74.45 0.0296456908307138 -0.811800830743971 -0.614175007315312 -0.960716353370505 -0.560975494729554 nephrolithiasis susceptibility caused by SLC26A1 AR Limited;Moderate 610130 ?Nephrolithiasis, calcium oxalate, 167030 (3) AR AR yes 8 1.0564e-11 4.0130e-06 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SLC49A3 NM_001294341 675617 682940 7323 1683 100 no 10 txStart-txEnd 5'UTR-3'UTR 675617 682940 gnomAD-SV_v2.1_DUP_4_10859 4:673000-683050 0.0882 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 SNORD162 NR_145783 4666052 4666150 98 0 0 no 1 txStart-txEnd UTR 4666052 4666150 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 SORCS2 NM_020777 7194264 7744554 550290 3480 100 no 27 txStart-txEnd 5'UTR-3'UTR 7194264 7744554 1011057;1013740;1013908;1013932;1014168;1014289;1014370;101617;1024160;1033262;103421;1035837;1035838;1035839;1035840;1035841;1035842;1035843;1051474;105303;111501;11258;113381;122148;128337;128338;128339;133563;133564;133565;14636;1477746;14797;14805;1515797;153890;15515;161883;1645823;165467;16713;170328;174349;175720;182774;184746;18587;187631;1881555;188640;195150;... gain;loss 69.5 1.29231994213647 0.27620541213653 0.660060919341019 -1.05139548669208 0.853955018782722 2 3.1696e-03 2.6463e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SPON2 NM_001199021 1160720 1202750 42030 996 100 no 8 txStart-txEnd 5'UTR-3'UTR 1160720 1202750 41519;41520 loss 77.93 0.386184284132793 -0.507819648222944 -0.233252267365632 0.982292085246316 0.77606556285772 9 2.6609e-15 1.0881e-06 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 STK32B NM_018401 5053206 5502716 449510 1245 100 no 12 txStart-txEnd 5'UTR-3'UTR 5053206 5502716 1004823;1007677;10184;1027607;1027638;1033236;1033238;1033239;1052805;1057831;1060917;1063798;1069420;1070055;1070266;1072175;1074112;11244;11245;1142068;1304163;13260;150666;167036;1679753;1801943;195118;196390;196656;2139871;21997;21998;22826;22827;229010;230359;2308272;24454;24455;2585054;26127;276969;276970;276972;276978;276980;2974848;3103240;322688;327704;329662;... gain;loss 39.31 -0.246593908057665 0.0285262483698947 -0.063872653370671 -2.65953872619111 -2.04902349969142 5 4.9116e-08 4.3235e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3-p16.2 STX18 NM_016930 4420695 4543775 123080 1008 100 no 11 txStart-txEnd 5'UTR-3'UTR 4420695 4543775 106193;106358;1217715;1310939;2065540;2262085;2794725;3111299;38745;53278;54942;557915;563850;563851;65871;709371;709372;70947;72950;73046;73051;76939;772099;772100;80739;80956;80957;81927;82978;86653;93080 gain;loss 39.55 0.843231894587517 0.108678775214296 0.455109011286475 -0.165997903989801 0.517811238015827 5 2.4881e-07 1.1678e-06 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 STX18-AS1 NR_037888 4543857 4712664 168807 0 0 no 6 txStart-txEnd UTR 4543857 4712664 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 STX18-IT1 NR_126434 4477847 4483427 5580 0 0 no 4 txStart-txEnd UTR 4477847 4483427 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TACC3 NM_006342 1723247 1746897 23650 2517 100 no 16 txStart-txEnd 5'UTR-3'UTR 1723247 1746897 595624 gain 92.5 -0.738565549612952 -1.04002887445022 -0.98783763752124 -1.00228696058413 -1.35276544118498 3 2.7082e-07 9.1952e-02 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 TADA2B NM_152293 7045098 7059677 14579 1263 100 no 2 txStart-txEnd 5'UTR-3'UTR 7045098 7059677 53.19 0.052084742182682 -0.284361515719772 -0.145832700564166 0.664832774210228 4.02698047878354 2 7.2366e-01 3.4506e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 TBC1D14 NM_001113361 6911170 7034845 123675 2082 100 no 14 txStart-txEnd 5'UTR-3'UTR 6911170 7034845 1108591;2537136;264163;2856302;701807;779357 gain;loss 58.66 0.38643088540431 0.788716334548764 0.774883176364413 -0.521938260031064 1.10884704568458 2 3.9267e-02 9.0900e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMED11P NR_033768 1108984 1116952 7968 0 0 no 4 txStart-txEnd UTR 1108984 1116952 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM128 NM_001297551 4237268 4249950 12682 498 100 no 5 txStart-txEnd 5'UTR-3'UTR 4237268 4249950 73.9 0.701580942281967 -0.111669494459405 8 1.9994e-04 1.1006e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM129 NM_001127266 1717678 1723050 5372 1089 100 no 4 txStart-txEnd 5'UTR-3'UTR 1717678 1723050 60.14 1.8774465029651 0.292414150336672 8 2.3074e-11 1.5746e-06 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM175 NM_032326 926247 952443 26196 1515 100 no 11 txStart-txEnd 5'UTR-3'UTR 926247 952443 1068686;772688 loss 72.33 0.68130369659025 -0.684900012122083 -0.281672783681246 -0.335178666431938 -0.288196719712539 6 3.0549e-09 4.3963e-04 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM271 NM_001362796 567668 570084 2416 1158 83 no 1 txStart-txEnd 5'UTR-3'UTR 567668 570084 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TNIP2 NM_024309 2743374 2758063 14689 1290 100 no 6 txStart-txEnd 5'UTR-3'UTR 2743374 2758063 81.36 0.00376891322505335 0.175301121417126 0.165045961017247 0.837642525932054 1.18082169671465 3 1.5926e-03 2.9733e-06 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 TRMT44 NM_152544 8442503 8478282 35779 2274 100 no 11 txStart-txEnd 5'UTR-3'UTR 8442503 8478282 1028618;1028622 gain;loss 87.71 -2.36525961978995 -1.15479952515637 -1.59282400997772 -0.488109075837714 -1.79889045378054 7 2.0315e-22 1.4776e-13 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L10 NM_001256852 9212382 9213975 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9212382 9213975 DDD:12912;DDD:12919;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 1000g;DDD:12912;DDD:12915;DDD:12919;dgv923e199;esv3599566 4:9176165-9236152;4:9157569-9214307;4:9157569-9214307;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 88.87 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L11 NM_001256854 9217130 9218723 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9217130 9218723 DDD:12912;DDD:12919;DDD:12922;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:9212771-9237062;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9176165-9236152;4:9212771-9237062;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 92.38 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L12 NM_001256853 9221877 9223470 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9221877 9223470 DDD:12912;DDD:12919;DDD:12922;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:9212771-9237062;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9176165-9236152;4:9212771-9237062;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 91.28 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L13 NM_001256855 9226621 9228214 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9226621 9228214 DDD:12912;DDD:12919;DDD:12922;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:9212771-9237062;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9176165-9236152;4:9212771-9237062;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 93.57 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L15 NM_001256894 9236110 9237772 1662 1662 100 no 1 txStart-txEnd 5'UTR-3'UTR 9236110 9237772 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 88.6 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L17 NM_001256857 9245604 9247197 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9245604 9247197 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 91.84 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L18 NM_001256859 9217130 9218723 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9217130 9218723 DDD:12912;DDD:12919;DDD:12922;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:9212771-9237062;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9176165-9236152;4:9212771-9237062;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 91.4 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L19 NM_001256860 9255103 9256696 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9255103 9256696 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 89.82 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L20 NM_001256861 9217130 9218723 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9217130 9218723 DDD:12912;DDD:12919;DDD:12922;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:9212771-9237062;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9176165-9236152;4:9212771-9237062;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 92.3 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L21 NM_001256862 9221877 9223470 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9221877 9223470 DDD:12912;DDD:12919;DDD:12922;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:9176165-9236152;4:9212771-9237062;4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9176165-9236152;4:9212771-9237062;4:9158155-9232046;4:9160215-9232041;4:9043826-9467101 1.0000 93.14 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L22 NM_001256863 9259849 9261442 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9259849 9261442 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 90.3 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L24 NM_001242327 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 94.26 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L25 NM_001242326 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 92.83 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L26 NM_001242328 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 92.3 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L27 NM_001242330 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 94.31 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L28 NM_001242331 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 95.78 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L29 NM_001242332 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 94.78 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L30 NM_001256867 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 94.83 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L5 NM_001242329 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 93.97 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L6P NR_027279 9369599 9370796 1197 0 0 no 1 txStart-txEnd UTR 9369599 9370796 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L9P NR_046416 9360107 9361700 1593 0 0 no 1 txStart-txEnd UTR 9360107 9361700 DDD:12912;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 4:8952199-9486394;4:8958204-9492295;4:8959918-9493802;4:9009830-9541289;4:9043826-9467101 0.5978 DDD:12912 4:9043826-9467101 0.0130 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 UVSSA NM_001317934 1340995 1381837 40842 2130 100 no 14 txStart-txEnd 5'UTR-3'UTR 1340995 1381837 UV-sensitive syndrome 3, 614640 (3) AR morbid:UVSSA 4:1341344-1381837 1 771150 loss 30 81.41 -1.108132588085 -3.07621828146639 UV-sensitive syndrome;UV-sensitive syndrome 3 AR Definitive;Strong;Supportive 22466610[PMID]_22466611[PMID]_22466612[PMID] 614632 UV-sensitive syndrome 3, 614640 (3) AR AR yes 7 5.4127e-25 8.8875e-14 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 WFS1 NM_001145853 6271576 6304992 33416 2673 100 no 8 txStart-txEnd 5'UTR-3'UTR 6271576 6304992 ?Cataract 41, 116400 (3) AD;Deafness, AD 6;14;38, 600965 (3) AD;Wolfram syndrome 1, 222300 (3) AR;Wolfram-like syndrome, AD, 614296 (3) AD;Diabetes mellitus, noninsulin-dependent, association with, 125853 (3) AD morbid:WFS1 4:6271577-6304992 78 Abnormality_of_the_cervical_spine;Abnormality_of_the_diaphragm;Abnormality_of_the_vertebral_column;Arachnodactyly;Autosomal_dominant_nonsyndromic_hearing_loss_6;Cataract_41;Cerebellar_vermis_hypoplasia;Cleft_palate;Congenital_laryngomalacia;Dandy-Walker_syndrome;Diabetes_mellitus;Diaphragmatic_eventration;Duane_retraction_syndrome;Feeding_difficulties;Global_developmental_delay;Hydronephrosis;Hydroureter;Inborn_genetic_diseases;Microglossia;Micrognathia;Night_blindness;Nonsyndromic_genetic_hearing_loss;Rare_genetic_deafness;See_cases;Sensorineural_hearing_loss_disorder;Small_hand;Type_2_diabetes_mellitus;WFS1-Related_Spectrum_Disorders;WFS1-related_disorder;Wolfram-like_syndrome;Wolfram_syndrome;Wolfram_syndrome_1 107748;320364;32350;44904;51246;59959;67149;973360 gain;loss 0 0 33.79 0.279433736423428 0.30418592454869 0.420298457025828 Wolfram syndrome;Wolfram syndrome 1;Wolfram-like syndrome;autosomal dominant nonsyndromic hearing loss;early-onset nuclear cataract AD;AR Definitive;Strong;Supportive 10521293;11161832;11295831;11317648;11709537;12073007;12107816;12707373;12754709;14724730;15070927;15151504;15277431;15503287;15605410;16151413;16442662;16459465;16648378;16806192[PMID]_12913071[PMID];17568405;18544103;18660851;18806274;19042979;19160074;20069065;20069065[PMID]_20301750[PMID];20301607[PMID]_24148127[PMID];20875904;21067485;21446023;21538838;21564155;21602428;21623591;21726277;21823543;21968327;22226368;22238590;22311385;22781099;23103830;23373429;23531866[PMID];25250959;25390390;27395765;28802351;29529044;9771706 606201 ?Cataract 41, 116400 (3) AD;Deafness, AD 6/14/38, 600965 (3) AD;Wolfram syndrome 1, 222300 (3) AR;Wolfram-like syndrome, AD, 614296 (3) AD;(Diabetes mellitus, noninsulin-dependent, association with), 125853 (3) AD AD;AR yes yes 9 1.6231e-38 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZBTB49 NM_001330625 4291977 4323510 31533 2298 100 no 8 txStart-txEnd 5'UTR-3'UTR 4291977 4323510 89.21 -0.48130989574319 0.452744382601107 0.130333981724112 -0.597063638061633 0.18239534186363 4 1.3752e-08 9.1642e-03 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZFYVE28 NM_020972 2271323 2420372 149049 2664 100 no 13 txStart-txEnd 5'UTR-3'UTR 2271323 2420372 1004782;1767057;191262;2444715;2994794;304613;305190;307267;324444;379298;379650;400287;550613;552440;595646;595647;596492;596551;771752;771755;771756;771757;771775;771778;771781;771785;777955;795798;807953;814241;821947;821948 gain;loss 65.21 -0.00272190900027315 -0.788064481059993 -0.590406277851698 -0.457051628812482 -0.248524904723244 2 7.2340e-02 8.8846e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF141 NM_003441 331602 378657 47055 1425 100 no 4 txStart-txEnd 5'UTR-3'UTR 331602 378657 658282;726705 loss 30 89.36 -0.117374836114298 -1.63248668554434 -1.22454087327741 0.724425471954094 -0.520531332003985 postaxial polydactyly type A AR Supportive 26394607[PMID]_23160277[PMID] 194648 ?Polydactyly, postaxial, type A6, 615226 (3) AR AR yes 7 1.0393e-01 1.6189e-01 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF595 NM_001286052 53178 88099 16547 1717 92 yes 9 intron2-txEnd CDS-3'UTR 12103 5' 71552 88099 esv2763806 4:12282-121562 0.0100 93 -2.08573739588537 -0.684191486481177 6 3.0550e-01 1.7753e-05 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF718 NM_001289930 124357 157949 33592 1214 100 yes 2 txStart-txEnd 5'UTR-3'UTR 124357 157949 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF721 NM_133474 433778 492945 59167 2772 100 no 3 txStart-txEnd 5'UTR-3'UTR 433778 492945 96.95 -1.7693057852588 -2.76319865584382 9 9.4789e-02 5.9729e-11 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF732 NM_001137608 264463 299263 34800 1758 100 no 4 txStart-txEnd 5'UTR-3'UTR 264463 299263 672573;672574;672575;700031;700032 loss 90.28 0.287750339613682 0.450417704041247 0.400052517453145 -1.34614550091757 -3.06736199452323 7 9.8159e-02 1.3118e-09 full=5 -4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF876P NR_027481 206388 249773 43385 0 0 no 2 txStart-txEnd UTR 206388 249773 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA full q11.23 ABHD11;ABHD11-AS1;BAZ1B;BCL7B;BUD23;CLDN3;CLDN4;CLIP2;DNAJC30;EIF4H;ELN;FKBP6;FZD9;GTF2I;GTF2IRD1;LAT2;LIMK1;LOC101926943;METTL27;MIR10525;MIR4284;MIR590;MLXIPL;RFC2;STX1A;TBL2;TMEM270;TRIM50;VPS37D 29 ACOX1 (morbid/RE=mTL_miRNA);ACSL6 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AGTPBP1 (morbid/RE=mTL_miRNA);AKR1D1 (morbid/RE=mTL_miRNA);ALDH6A1 (morbid/RE=mTL_miRNA);ALDOA (morbid/RE=mTL_miRNA);APC (HI=3/morbid/RE=mTL_miRNA);APTX (morbid/RE=mTL_miRNA);ARSK (morbid/RE=mTL_miRNA);ATL3 (morbid/RE=mTL_miRNA);ATP13A3 (morbid/RE=mTL_miRNA);ATP6V0A2 (morbid/RE=mTL_miRNA);ATP6V1A (morbid/RE=mTL_miRNA);ATXN1 (morbid/RE=mTL_miRNA);BACH1 (morbid/RE=mTL_miRNA);BVES (morbid/RE=mTL_miRNA);C3 (morbid/RE=mTL_miRNA);C8orf37 (morbid/RE=mTL_miRNA);CAPN15 (morbid/RE=mTL_miRNA);CASP10 (morbid/RE=mTL_miRNA);CD3D (morbid/RE=mTL_miRNA);CDC73 (HI=3/morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CHRNB1 (morbid/RE=mTL_miRNA);CISD2 (morbid/RE=mTL_miRNA);CITED2 (morbid/RE=mTL_miRNA);CLEC7A (morbid/RE=mTL_miRNA);CLN8 (morbid/RE=mTL_miRNA);COL18A1 (morbid/RE=mTL_miRNA);COX20 (morbid/RE=mTL_miRNA);COX6B1 (morbid/RE=mTL_miRNA);CPE (morbid/RE=mTL_miRNA);CPT1A (morbid/RE=mTL_miRNA);CRIPT (morbid/RE=mTL_miRNA);CRTAP (morbid/RE=mTL_miRNA);CSNK1D (morbid/RE=mTL_miRNA);CTSB (morbid/RE=mTL_miRNA);CYCS (morbid/RE=mTL_miRNA);DARS2 (morbid/RE=mTL_miRNA);DNA2 (morbid/RE=mTL_miRNA);DNAAF3 (morbid/RE=mTL_miRNA);DNAJB13 (morbid/RE=mTL_miRNA);DNAJC3 (morbid/RE=mTL_miRNA);DSG3 (morbid/RE=mTL_miRNA);EDARADD (morbid/RE=mTL_miRNA);EIF2S3 (morbid/RE=mTL_miRNA);ELP2 (morbid/RE=mTL_miRNA);EMP2 (morbid/RE=mTL_miRNA);EPB41 (morbid/RE=mTL_miRNA);EPB42 (morbid/RE=mTL_miRNA);EPG5 (morbid/RE=mTL_miRNA);EXOSC2 (morbid/RE=mTL_miRNA);FANCF (morbid/RE=mTL_miRNA);FARSB (morbid/RE=mTL_miRNA);FBXW7 (morbid/RE=mTL_miRNA);FGF12 (morbid/RE=mTL_miRNA);FGFR1 (HI=3/morbid/RE=mTL_miRNA);FLCN (HI=3/morbid/RE=mTL_miRNA);FOXG1 (HI=3/morbid/RE=mTL_miRNA);FXN (morbid/RE=mTL_miRNA);G6PC (morbid/RE=mTL_miRNA);GABRB3 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GATAD2B (HI=3/morbid/RE=mTL_miRNA);GBA2 (morbid/RE=mTL_miRNA);GFPT1 (morbid/RE=mTL_miRNA);GGCX (morbid/RE=mTL_miRNA);GNAQ (morbid/RE=mTL_miRNA);GNB4 (morbid/RE=mTL_miRNA);GPC4 (morbid/RE=mTL_miRNA);GSR (morbid/RE=mTL_miRNA);HEXA (morbid/RE=mTL_miRNA);HINT1 (morbid/RE=mTL_miRNA);HNRNPA1 (morbid/RE=mTL_miRNA);HNRNPK (HI=3/morbid/RE=mTL_miRNA);IDS (HI=3/morbid/RE=mTL_miRNA);IFT74 (morbid/RE=mTL_miRNA);IGF1 (morbid/RE=mTL_miRNA);IGF2R (morbid/RE=mTL_miRNA);IL10RB (morbid/RE=mTL_miRNA);IL12B (morbid/RE=mTL_miRNA);IL6R (morbid/RE=mTL_miRNA);IL6ST (morbid/RE=mTL_miRNA);ING1 (morbid/RE=mTL_miRNA);IREB2 (morbid/RE=mTL_miRNA);ITGB3 (morbid/RE=mTL_miRNA);JPH2 (morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNJ5 (morbid/RE=mTL_miRNA);KCNJ6 (morbid/RE=mTL_miRNA);KIF1C (morbid/RE=mTL_miRNA);KLHL15 (morbid/RE=mTL_miRNA);KLHL7 (morbid/RE=mTL_miRNA);KLLN (morbid/RE=mTL_miRNA);KMT5B (morbid/RE=mTL_miRNA);KREMEN1 (morbid/RE=mTL_miRNA);LDHA (morbid/RE=mTL_miRNA);LDLR (HI=3/morbid/RE=mTL_miRNA);LIAS (morbid/RE=mTL_miRNA);LMBRD2 (morbid/RE=mTL_miRNA);LRIG2 (morbid/RE=mTL_miRNA);LYRM7 (morbid/RE=mTL_miRNA);MALT1 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MCM4 (morbid/RE=mTL_miRNA);MCM9 (morbid/RE=mTL_miRNA);MED13 (morbid/RE=mTL_miRNA);MED13L (HI=3/morbid/RE=mTL_miRNA);MED17 (morbid/RE=mTL_miRNA);MESD (morbid/RE=mTL_miRNA);MIB1 (morbid/RE=mTL_miRNA);MRPS16 (morbid/RE=mTL_miRNA);MSH3 (morbid/RE=mTL_miRNA);MXI1 (morbid/RE=mTL_miRNA);MYH9 (morbid/RE=mTL_miRNA);MYPN (morbid/RE=mTL_miRNA);NAA15 (HI=3/morbid/RE=mTL_miRNA);NCF1 (morbid/RE=EA_enhancer+GH_Enhancer+GH_Promoter/Enhancer);NCKAP1 (HI=3/RE=mTL_miRNA);NDRG1 (morbid/RE=mTL_miRNA);NDUFA12 (morbid/RE=mTL_miRNA);NECTIN4 (morbid/RE=mTL_miRNA);NFIB (morbid/RE=mTL_miRNA);NHLRC2 (morbid/RE=mTL_miRNA);NHS (HI=3/morbid/RE=mTL_miRNA);NIPA1 (morbid/RE=mTL_miRNA);NKAP (morbid/RE=mTL_miRNA);NMNAT1 (morbid/RE=mTL_miRNA);NR3C1 (morbid/RE=mTL_miRNA);NUP133 (morbid/RE=mTL_miRNA);ORC4 (morbid/RE=mTL_miRNA);ORC6 (morbid/RE=mTL_miRNA);OSBPL2 (morbid/RE=mTL_miRNA);OSMR (morbid/RE=mTL_miRNA);PACS1 (morbid/RE=mTL_miRNA);PACS2 (morbid/RE=mTL_miRNA);PAH (morbid/RE=mTL_miRNA);PDE11A (morbid/RE=mTL_miRNA);PEX13 (morbid/RE=mTL_miRNA);PEX2 (morbid/RE=mTL_miRNA);PGAP1 (morbid/RE=mTL_miRNA);PHEX (HI=3/morbid/RE=mTL_miRNA);PHKG2 (morbid/RE=mTL_miRNA);PIGA (morbid/RE=mTL_miRNA);PIGM (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);PLA2G4A (morbid/RE=mTL_miRNA);PLA2G7 (morbid/RE=mTL_miRNA);PMPCA (morbid/RE=mTL_miRNA);PNPT1 (morbid/RE=mTL_miRNA);POC1A (morbid/RE=mTL_miRNA);POGZ (HI=3/morbid/RE=mTL_miRNA);POLR1B (morbid/RE=mTL_miRNA);POLR3A (morbid/RE=mTL_miRNA);PPM1D (morbid/RE=mTL_miRNA);PPP1R15B (morbid/RE=mTL_miRNA);PPP2R1A (morbid/RE=mTL_miRNA);PRICKLE1 (morbid/RE=mTL_miRNA);PRKCA (morbid/RE=mTL_miRNA);PRPF4 (morbid/RE=mTL_miRNA);PRPF6 (morbid/RE=mTL_miRNA);PTGIS (morbid/RE=mTL_miRNA);PTPN14 (morbid/RE=mTL_miRNA);PYROXD1 (morbid/RE=mTL_miRNA);QRSL1 (morbid/RE=mTL_miRNA);RAB27A (morbid/RE=mTL_miRNA);RAD51 (morbid/RE=mTL_miRNA);RB1 (HI=3/morbid/RE=mTL_miRNA);RILPL1 (morbid/RE=mTL_miRNA);RNF2 (morbid/RE=mTL_miRNA);RNF6 (morbid/RE=mTL_miRNA);RSPH3 (morbid/RE=mTL_miRNA);RSRC1 (morbid/RE=mTL_miRNA);SBDS (morbid/RE=mTL_miRNA);SCARB2 (morbid/RE=mTL_miRNA);SCO1 (morbid/RE=mTL_miRNA);SCUBE3 (morbid/RE=mTL_miRNA);SEC23B (morbid/RE=mTL_miRNA);SELENOI (morbid/RE=mTL_miRNA);SERPING1 (morbid/RE=mTL_miRNA);SETD1B (morbid/RE=mTL_miRNA);SETD5 (HI=3/morbid/RE=mTL_miRNA);SF3B1 (morbid/RE=mTL_miRNA);SGCB (morbid/RE=mTL_miRNA);SGPL1 (morbid/RE=mTL_miRNA);SHOC2 (morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC19A3 (morbid/RE=mTL_miRNA);SLC1A2 (morbid/RE=mTL_miRNA);SLC25A4 (morbid/RE=mTL_miRNA);SLC25A46 (morbid/RE=mTL_miRNA);SLC33A1 (morbid/RE=mTL_miRNA);SLC9A7 (morbid/RE=mTL_miRNA);SMAD3 (HI=3/morbid/RE=mTL_miRNA);SORD (morbid/RE=mTL_miRNA);SP110 (morbid/RE=mTL_miRNA);SPATA5 (morbid/RE=mTL_miRNA);SPN (morbid/RE=mTL_miRNA);SPPL2A (morbid/RE=mTL_miRNA);SPRY4 (morbid/RE=mTL_miRNA);STIL (morbid/RE=mTL_miRNA);STK4 (morbid/RE=mTL_miRNA);STX16 (morbid/RE=mTL_miRNA);STXBP2 (morbid/RE=mTL_miRNA);TAF1 (morbid/RE=mTL_miRNA);TAF8 (morbid/RE=mTL_miRNA);TAOK1 (morbid/RE=mTL_miRNA);TBX18 (morbid/RE=mTL_miRNA);TCN2 (morbid/RE=mTL_miRNA);TET2 (morbid/RE=mTL_miRNA);TGFB1 (morbid/RE=mTL_miRNA);TGFBR2 (morbid/RE=mTL_miRNA);THG1L (morbid/RE=mTL_miRNA);TIMM8A (HI=3/morbid/RE=mTL_miRNA);TMEM216 (morbid/RE=mTL_miRNA);TMEM70 (morbid/RE=mTL_miRNA);TNFRSF11A (morbid/RE=mTL_miRNA);TNFRSF13B (morbid/RE=mTL_miRNA);TNPO3 (morbid/RE=mTL_miRNA);TRAF3IP1 (morbid/RE=mTL_miRNA);TRPM6 (morbid/RE=mTL_miRNA);TRPS1 (HI=3/morbid/RE=mTL_miRNA);TTR (morbid/RE=mTL_miRNA);UGDH (morbid/RE=mTL_miRNA);UQCRB (morbid/RE=mTL_miRNA);WAC (HI=3/morbid/RE=mTL_miRNA);WEE2 (morbid/RE=mTL_miRNA);WNK1 (morbid/RE=mTL_miRNA);XIAP (HI=3/morbid/RE=mTL_miRNA);XPNPEP3 (morbid/RE=mTL_miRNA);XRCC2 (morbid/RE=mTL_miRNA);YIPF5 (morbid/RE=mTL_miRNA);YRDC (morbid/RE=mTL_miRNA);ZBTB16 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA);ZBTB7A (morbid/RE=mTL_miRNA);ZEB1 (morbid/RE=mTL_miRNA);ZEB2 (HI=3/morbid/RE=mTL_miRNA) dbVar:nssv15146175;nssv15148276;dbVar:nssv15146450;dbVar:nssv15147327;dbVar:nssv17955524 7:72766114-74133473;7:72766313-74133327;7:72766314-74133332;7:73944169-74138459 Cutis laxa, AD, 123700 (3) AD;Supravalvar aortic stenosis, 185500 (3) AD;Leber hereditary optic neuropathy, AR, 619382 (3) AR HI3:ELN;dbVar:nssv15128343;dbVar:nssv15128578;dbVar:nssv15130113;dbVar:nssv15130169;dbVar:nssv15140244;dbVar:nssv15141480;dbVar:nssv15145649;nssv15146804;nssv15153080;dbVar:nssv15146451;dbVar:nssv15146687;dbVar:nssv15146708;dbVar:nssv15151951;nssv15605841;dbVar:nssv15167740;dbVar:nssv15770120;dbVar:nssv16208140;dbVar:nssv16213814;dbVar:nssv16214480;dbVar:nssv16214500;dbVar:nssv17172745;dbVar:nssv17172746;dbVar:nssv17955650;dbVar:nssv17971140;morbid:DNAJC30;morbid:ELN 7:72726579-74139390;7:72766114-74133473;7:72766313-74133327;7:72766314-74133332;7:72772523-74133319;7:72996565-73597315;7:73023063-73524207;7:73095248-73097783;7:73150890-73604636;7:73187644-73501025;7:73442120-73484237;7:73442459-73483087;7:73442499-73442619;7:73442499-73483050;7:73442503-73484236;7:73442509-73483040;7:73449675-73483050;7:73461986-73483030;7:73470471-73498327;7:73471703-73483040;7:73482968-73483050;7:73482988-73484237;7:73791726-74133273 7q11.23 recurrent (Williams-Beuren syndrome) region (includes ELN) dbVar:nssv15777247;dbVar:nssv15168013;dbVar:nssv15161666;nssv15161679;dbVar:nssv15168014;dbVar:nssv15146013;dbVar:nssv15146778;dbVar:nssv15147714;dbVar:nssv15147012;dbVar:nssv15147013;dbVar:nssv15755212;dbVar:nssv15147334;dbVar:nssv15151509;dbVar:nssv15154519;dbVar:nssv15152109;dbVar:nssv15153678;dbVar:nssv15148173;dbVar:nssv15149887;dbVar:nssv15147399;dbVar:nssv15148904;dbVar:nssv15174166;dbVar:nssv15128409;dbVar:nssv15150793;dbVar:nssv16254014;dbVar:nssv15148877;dbVar:nssv15147014;dbVar:nssv15149513;dbVar:nssv15146773;dbVar:nssv15151227;dbVar:nssv15147017;dbVar:nssv15146395;dbVar:nssv15147458;dbVar:nssv15126184;dbVar:nssv15150228;dbVar:nssv15147556;dbVar:nssv15146449;dbVar:nssv15151508;dbVar:nssv15150733;dbVar:nssv15154518;dbVar:nssv17955880;dbVar:nssv15146933;dbVar:nssv16215249;dbVar:nssv15167739;TS3:ISCA-37392;dbVar:nssv15148970 7:10366-159119707;7:10705-159122532;7:43362-159119707;7:44936-159126310;7:62437464-75044630;7:71644078-78793387;7:71968213-74133332;7:72196406-74991125;7:72233836-74285345;7:72364527-73780265;7:72408603-74193374;7:72576873-74175429;7:72577022-74147166;7:72577022-74197846;7:72577022-74859638;7:72589516-74154603;7:72589516-74165401;7:72606410-74193403;7:72606410-74300084;7:72606451-74153206;7:72650008-74188572;7:72659675-74143240;7:72659675-74164894;7:72663963-74193403;7:72665463-74139573;7:72677174-74143140;7:72677302-74143060;7:72677302-74143240;7:72679398-74139573;7:72683245-74267189;7:72685735-74142327;7:72685764-74189674;7:72692113-74154497;7:72700128-74146858;7:72700415-74139573;7:72700525-74069858;7:72700525-74142256;7:72701019-74143240;7:72717346-74133310;7:72718279-74140708;7:72722982-74141840;7:72743984-74145064;7:72744456-74142510;7:72766314-74481540 0.89;0.89;0.89;0.89;11.21;19.76;64.97;50.55;68.87;74.43;79.16;88.38;89.98;87.17;61.89;90.27;89.65;89.02;83.42;91.34;91.83;95.23;93.86;92.37;95.84;96.37;96.39;96.38;96.76;89.20;96.99;93.94;96.61;97.66;98.17;98.10;97.99;97.96;99.35;99.32;99.57;99.60;99.78;80.05 7q11.23 recurrent (Williams-Beuren syndrome) region (includes ELN) dbVar:nssv15161318;dbVar:nssv15148211;dbVar:nssv15147057;dbVar:nssv15147200;dbVar:nssv16255682;dbVar:nssv15146320;dbVar:nssv15146676;dbVar:nssv16867365;dbVar:nssv15167734;dbVar:nssv15146211;dbVar:nssv16254015;dbVar:nssv15151112;dbVar:nssv15145801;dbVar:nssv15152099;dbVar:nssv15151511;dbVar:nssv15145887;dbVar:nssv15147427;dbVar:nssv15153677;dbVar:nssv15154521;dbVar:nssv16208139;dbVar:nssv15145827;dbVar:nssv15148206;dbVar:nssv15151289;dbVar:nssv15125131;dbVar:nssv15167735;dbVar:nssv15148192;dbVar:nssv15167736;dbVar:nssv15168977;dbVar:nssv16215159;dbVar:nssv15129678;dbVar:nssv15147158;dbVar:nssv15606134;dbVar:nssv15145898;dbVar:nssv15151092;dbVar:nssv15755220;dbVar:nssv15147160;dbVar:nssv15147159;dbVar:nssv15145802;dbVar:nssv15147457;dbVar:nssv15148226;dbVar:nssv15147515;dbVar:nssv15147502;dbVar:nssv15148195;dbVar:nssv15147550;dbVar:nssv15605840;dbVar:nssv15149859;dbVar:nssv15150016;dbVar:nssv15146951;dbVar:nssv16297072;dbVar:nssv15154517;dbVar:nssv15146637;dbVar:nssv15149107;dbVar:nssv15150231;dbVar:nssv15150699;dbVar:nssv15150637;dbVar:nssv15151346;dbVar:nssv15148257;dbVar:nssv15150643;dbVar:nssv15149860;dbVar:nssv15151090;dbVar:nssv15167737;dbVar:nssv15605774;dbVar:nssv8640006;dbVar:nssv15167738;dbVar:nssv15147726;dbVar:nssv15755221;HI3:ISCA-37392;dbVar:nssv15605838;dbVar:nssv15605839;dbVar:nssv15147324;dbVar:nssv15147329;dbVar:nssv15145670;dbVar:nssv15145679;nssv15146800;dbVar:nssv15146612;dbVar:nssv15124428;dbVar:nssv15776001;dbVar:nssv15120782;dbVar:nssv15148954;dbVar:nssv15147202 7:54186-159075079;7:62196743-75061986;7:68133295-72806397;7:68847340-77453149;7:68977231-73939510;7:70690331-81364973;7:70926113-72806397;7:71847969-73391310;7:72305672-74196360;7:72401087-74285345;7:72403118-76709600;7:72456605-76007380;7:72507130-74142327;7:72536981-74629034;7:72589516-74386749;7:72606410-74193403;7:72606410-74285345;7:72608515-74386749;7:72612043-74574641;7:72621723-76007380;7:72636007-74339014;7:72637825-74203685;7:72643632-74142190;7:72644632-74144422;7:72650107-74138603;7:72650121-74142256;7:72650266-74138603;7:72653307-74134911;7:72657229-74160300;7:72677238-74144422;7:72681398-74137354;7:72682339-74141250;7:72685735-74142327;7:72691243-74142190;7:72699383-74142329;7:72700415-74122179;7:72700415-74137354;7:72700415-74139573;7:72700415-74142327;7:72700415-74172913;7:72700415-74193403;7:72700415-74285345;7:72700511-74142190;7:72700525-74141494;7:72700997-74142190;7:72701019-74141493;7:72708238-74133273;7:72708238-74339044;7:72717370-74142224;7:72718124-74141784;7:72718253-74133273;7:72718253-74133332;7:72718278-73898515;7:72718278-74141494;7:72718278-74141603;7:72718278-74141746;7:72718278-74142190;7:72718278-74146858;7:72718278-74259899;7:72718278-74287433;7:72719387-74218536;7:72721450-73959106;7:72722982-74141840;7:72722982-74200092;7:72722982-74217390;7:72726591-74142329;7:72744456-74142510;7:72744495-74339044;7:72744495-76038818;7:72766313-74193397;7:72766313-74339030;7:72766314-74285345;7:72766314-74339044;7:72766314-76351578;7:73591994-75914797;7:73799887-75388031;7:73992745-74991125;7:73992745-81661058;7:73992745-83618176 0.89;10.98;1.71;16.42;24.44;13.24;4.25;43.07;74.72;74.98;32.81;39.79;86.40;67.53;78.61;89.02;84.15;79.45;71.99;41.73;82.96;90.23;94.28;94.20;94.86;94.68;94.87;95.05;93.99;96.29;96.90;96.84;96.99;97.37;97.91;98.16;98.18;98.17;97.98;95.95;94.63;89.14;98.00;98.05;98.03;98.08;98.71;86.63;99.15;99.24;99.41;99.41;99.30;99.27;99.26;99.25;99.22;98.90;91.64;90.04;94.24;99.59;99.57;95.65;94.54;99.79;99.78;87.48;42.34;96.22;87.31;90.39;87.31;38.30;23.57;21.38;14.69;1.91;1.52 79 Autism;Cutis_laxa,_autosomal_dominant_1;DNAJC30-associated_disorder;Inborn_genetic_diseases;Intellectual_disability;Leber_hereditary_optic_neuropathy,_autosomal_recessive;Supravalvar_aortic_stenosis;Williams_syndrome 7:74110032-74113459 DDD:24519;7:74103674-74113108 DDD:24517 7:72893440-72893440 1000g;7:74111368-74111473 DDD:24520 7:73003696-73003760 CMRI:11_pbsv.DEL.1960_duplicate2;7:73190197-73190548 CMRI:1_pbsv.DEL.1066_duplicate1;7:73250467-73250564 CMRI:57_pbsv.DEL.1091_duplicate5;7:73250598-73250900 CMRI:13_pbsv.DEL.1493_duplicate2;7:73250845-73250971 CMRI:21_pbsv.DEL.1121_duplicate1;7:73329251-73331249 DDD:24505;7:73352682-73352732 gnomAD-SV_v2.1_DEL_7_82551;7:73549759-73550966 DDD:24507;7:73549766-73550955 1000g;7:73549766-73550966 gnomAD-SV_v2.1_DEL_7_82568;7:73549855-73551171 CMRI:1_pbsv.DEL.1075_duplicate3;7:73583161-73583725 gnomAD-SV_v2.1_DEL_7_82576;7:73628828-73628887 CMRI:2_pbsv.DEL.1459_duplicate2;7:73628935-73628993 CMRI:7_pbsv.DEL.1347_duplicate4;7:73784187-73784485 CMRI:0_pbsv.DEL.1106_duplicate2;7:73808133-73809046 esv2667384;7:73828494-73831271 1000g;7:73828496-73831357 DDD:24511;7:73829697-73831200 nsv607484;7:73828496-73831313 CMRI:0_pbsv.DEL.1107_duplicate2;7:74109884-74111477 DDD:24518... 7:72831554-72833141 DDD:24501;7:73047101-73047474 gnomAD-SV_v2.1_DEL_7_82515;7:73234825-73235127 CMRI:57_pbsv.DEL.1090_duplicate3;7:73250526-73250701 CMRI:1_pbsv.DEL.1068_duplicate4;7:73250743-73250819 CMRI:291_pbsv.DEL.1338_duplicate4;7:73250882-73250959 CMRI:9_pbsv.DEL.1085_duplicate4;7:73352676-73352730 gnomAD-SV_v2.1_DEL_7_82550;7:73474237-73474290 CLN:1207512;7:73549759-73550966 esv2670233;7:73549766-73550955 esv3613699;7:73549759-73550966 CMRI:1_pbsv.DEL.1074_duplicate5;7:73573576-73575743 DDD:24508;7:73628560-73628639 CMRI:129_pbsv.DEL.1356_duplicate1;7:73628869-73628954 CMRI:0_pbsv.DEL.1102_duplicate1;7:73784190-73784485 esv2661080;7:73808133-73809046 DDD:24510;7:73828449-73831263 gnomAD-SV_v2.1_DEL_7_82597;7:73828494-73831271 esv3613707;7:73828496-73831357 esv2662672;7:73834912-73838364 DDD:24515;7:73981931-73983378 DDD:24516... 1006381;1006449;1006450;1006451;1006454;1006458;1006460;1006461;1006462;1006465;1006467;1006469;1006470;1006471;1006476;1006478;1006479;1006481;1010483;1010651;1010670;1013864;1013904;1013906;1013907;1013909;1013913;1013921;1013923;1013924;1013930;1013932;103791;103793;103972;103974;103975;103978;103988;103989;103996;104005;104017;104018;104019;104030;104032;104034;104039;104057;104058;... gain;loss 0.370 0.355 7:72726181-72726486 AluSz 7:72700438-72744454;7:72700443-72744454 3 88.46 1.77201404347458 0.0159631069818757 0.491444562429841 2.70903614483931 4.23220859072885 618202;130160 yes 0 1.0000e+00 1.0000e+00 1.45 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3B (29 genes, +0.45);5F (+0.00) 5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 ABHD11 NM_148912 73150424 73153197 2773 948 100 no 6 txStart-txEnd 5'UTR-3'UTR 73150424 73153197 76.55 0.643446275430498 -0.675433866559718 -0.327510119466819 1.09331776236833 0.473373375061211 5 2.9581e-03 9.0329e-06 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 ABHD11-AS1 NR_026690 73149398 73150330 932 0 0 no 4 txStart-txEnd UTR 73149398 73150330 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 BAZ1B NM_001370402 72854736 72936623 81887 4452 100 no 19 txStart-txEnd 5'UTR-3'UTR 72854736 72936623 529378 loss 23.74 1.02239565516008 0.0159631069818757 0.395552906953086 -0.902054979760057 4.05717005254254 autism spectrum disorder AD Limited 0 1.0000e+00 1.0000e+00 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 BCL7B NM_001301061 72950685 72972020 21335 642 100 no 7 txStart-txEnd 5'UTR-3'UTR 72950685 72972020 28.63 1.05583278690403 -0.553040364632404 -0.0819162539430506 -0.44503506022657 1.74981493260157 3 1.8519e-01 7.0664e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 BUD23 NM_001202560 73097926 73112542 14616 897 100 no 13 txStart-txEnd 5'UTR-3'UTR 73097926 73112542 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 CLDN3 NM_001306 73183326 73184600 1274 663 75 no 1 txStart-txEnd 5'UTR-3'UTR 73183326 73184600 33.46 0.332553044404404 -0.966715148489597 -0.688425296234703 2.70903614483931 1.92914089110849 4 5.2233e-01 6.7854e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 CLDN4 NM_001305 73245325 73247019 1694 630 42 no 1 txStart-txEnd 5'UTR-3'UTR 73245325 73247019 23.72 0.563064431580096 -0.809178554455325 -0.46244511082827 -0.0167724140747313 0.933080799622852 9 6.9789e-05 1.3716e-04 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 CLIP2 NM_003388 73703736 73820265 116529 3141 100 no 17 txStart-txEnd 5'UTR-3'UTR 73703736 73820265 1376904;311922;312170;730235 gain;loss 47.98 1.014608801418 -0.895566510532316 -0.401705936344982 -0.746648021563001 2.45305749434808 0 9.9997e-01 9.9988e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 DNAJC30 NM_032317 73095247 73097783 2536 681 95 no 1 txStart-txEnd 5'UTR-3'UTR 73095247 73097783 Leber hereditary optic neuropathy, AR, 619382 (3) AR morbid:DNAJC30 7:73095248-73097783 1 DNAJC30-associated_disorder;Leber_hereditary_optic_neuropathy,_autosomal_recessive 80.16 0.717396479665947 -0.500797326082256 -0.15204008716984 1.08623431117684 1.71697083676563 Leber hereditary optic neuropathy MT Supportive 33465056[PMID] 618202 Leber hereditary optic neuropathy, AR, 619382 (3) AR AR yes 7 2.3092e-02 4.7983e-03 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 EIF4H NM_022170 73588685 73611426 22741 747 100 no 7 txStart-txEnd 5'UTR-3'UTR 73588685 73611426 520421;520564;521476 gain;loss 21.78 0.339580839486745 -0.49261121282204 -0.247951312124761 -0.250271670703448 3.27930650064444 2 4.3982e-01 9.2254e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 ELN NM_001278939 73442118 73484236 42118 2361 100 no 34 txStart-txEnd 5'UTR-3'UTR 73442118 73484236 Cutis laxa, AD, 123700 (3) AD;Supravalvar aortic stenosis, 185500 (3) AD dbVar:nssv15130113;dbVar:nssv15130169;dbVar:nssv15770120;dbVar:nssv16213814;dbVar:nssv16214480;dbVar:nssv16214500;dbVar:nssv17172746;dbVar:nssv17971140;morbid:ELN 7:73442459-73483087;7:73442499-73442619;7:73442499-73483050;7:73442503-73484236;7:73442509-73483040;7:73449675-73483050;7:73461986-73483030;7:73471703-73483040;7:73482968-73483050 77 Cutis_laxa,_autosomal_dominant_1;Inborn_genetic_diseases;Supravalvar_aortic_stenosis;Williams_syndrome 3 0 8.62 0.1188507761401 -1.61408470478924 -1.04153334326364 -0.09395744769762 -0.0129976080826519 autosomal dominant cutis laxa;cutis laxa, autosomal dominant 1;supravalvular aortic stenosis AD Definitive;Strong;Supportive 10190324;10190538;10942104[PMID]_19844261[PMID];11175284;11735026;16085695[PMID]_18348261[PMID];19844261;21309044;23442826;27866049;31560829;8132745;8541862;9215670;9215671 130160 Cutis laxa, AD, 123700 (3) AD;Supravalvar aortic stenosis, 185500 (3) AD AD yes 4 2.1429e-14 1.5200e-05 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 FKBP6 NM_003602 72742163 72772634 30471 984 100 no 9 txStart-txEnd 5'UTR-3'UTR 72742163 72772634 65.69 1.49986407027643 1.4396607305099 5 1.3955e-06 1.3060e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 FZD9 NM_003508 72848107 72850450 2343 1776 84 no 1 txStart-txEnd 5'UTR-3'UTR 72848107 72850450 46.95 0.247827425263201 -1.18776035129969 -0.895389454591556 4 1.9309e-03 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 GTF2I NM_032999 74072043 74175022 67347 943 31 yes 35 txStart-intron12 5'UTR-CDS 3733 3' 74072043 74139390 525619;529379;534294;538338;776782;776783;777959;777979;777991;778027 gain;loss 0 0 33.5 0.964550444182401 4.23220859072885 1 9.9592e-01 9.9935e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 GTF2IRD1 NM_001199207 73868235 74016920 148685 2931 100 no 27 txStart-txEnd 5'UTR-3'UTR 73868235 74016920 257633;257740;257750;280118;287214;291764;291839;291840;409861;596149;596444;598757;730239 gain;loss 0 0 47.51 1.77201404347458 -0.0325005901648791 0.491444562429841 0.977775575032158 2.53365459317235 1 9.0039e-01 9.9643e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 LAT2 NM_014146 73624335 73644164 19829 732 100 no 13 txStart-txEnd 5'UTR-3'UTR 73624335 73644164 88.46 0.592710857132059 -0.653878691847743 -0.292110083865967 0.385787155434006 -0.303087706786894 4 2.2295e-04 6.9106e-04 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 LIMK1 NM_002314 73498133 73536855 38722 1944 100 no 16 txStart-txEnd 5'UTR-3'UTR 73498133 73536855 596146;596546 loss 0 0 19.66 0.623604739936053 -0.79212126645541 -0.396805714672051 -0.48782967368913 2.85746490313868 0 9.9937e-01 9.9090e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 LOC101926943 NR_110044 74103270 74143256 36120 0 0 no 4 intron2-txEnd UTR 2349 5' 74103270 74139390 776783;777959;777979;777991 loss full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 METTL27 NM_152559 73248921 73256846 7925 738 100 no 6 txStart-txEnd 5'UTR-3'UTR 73248921 73256846 776775 loss full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MIR10525 NR_162116 74010294 74010353 59 0 0 no 1 txStart-txEnd UTR 74010294 74010353 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MIR4284 NR_036247 73125646 73125727 81 0 0 no 1 txStart-txEnd UTR 73125646 73125727 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MIR590 NR_030321 73605527 73605624 97 0 0 no 1 txStart-txEnd UTR 73605527 73605624 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MLXIPL NM_032951 73007531 73038852 31321 2559 100 no 17 txStart-txEnd 5'UTR-3'UTR 73007531 73038852 730221;733450;733479;776773 loss 36.45 0.942636989769333 -0.774220086661663 -0.327638361779731 0.58127606528246 1.2288879277127 2 4.7771e-02 6.7682e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 RFC2 NM_181471 73645831 73668729 22898 1065 100 no 11 txStart-txEnd 5'UTR-3'UTR 73645831 73668729 14.42 0.200864992787726 -0.430045328414053 -0.225638310792768 -0.430513909559958 1.53581142075512 5 2.2054e-06 4.0421e-05 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 STX1A NM_004603 73113539 73133999 20460 867 100 no 10 txStart-txEnd 5'UTR-3'UTR 73113539 73133999 1 Autism;Intellectual_disability 22.82 0.950800964625408 -0.794674734358171 -0.324619004824717 1.10438995088098 3.33806479625907 1 9.7850e-01 9.1048e-01 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 TBL2 NM_012453 72981867 72992909 11042 1344 100 no 7 txStart-txEnd 5'UTR-3'UTR 72981867 72992909 30.81 -0.199291215312469 -0.922199212243606 -0.751016280020485 0.200201742907301 0.554223709974506 4 1.8452e-04 4.3765e-03 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 TMEM270 NM_182504 73275488 73280220 4732 798 100 no 3 txStart-txEnd 5'UTR-3'UTR 73275488 73280220 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 TRIM50 NM_178125 72726531 72742085 15507 1464 100 no 7 txStart-exon7 5'UTR-3'UTR 928 3' 72726578 72742085 55.55 0.317380023327075 0.681275321847818 7 1.5479e-10 2.7256e-06 full=5 -7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 VPS37D NM_001077621 73082160 73086440 4280 756 100 no 4 txStart-txEnd 5'UTR-3'UTR 73082160 73086440 64.11 -0.0288746954043306 0.953055172354045 1 9.1622e-01 6.5635e-01 full=5 -1_196756232_196799302_DEL_1 1 196756232 196799302 -43070 DEL Benign NA full q31.3 CFHR1;CFHR3 2 ASPM (morbid/RE=EA_enhancer);CFH (morbid/RE=GH_Promoter/Enhancer) dbVar:nssv15121100 1:196757279-196796716 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15777262;dbVar:nssv15169967;dbVar:nssv15146388;dbVar:nssv15151024 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:182388774-249111240;1:185644664-221698833;1:187113114-224487119;1:195483440-249213000 0.02;0.02;0.02;0.04;0.06;0.12;0.12;0.08 dbVar:nssv15129680;dbVar:nssv16207750;dbVar:nssv15146573;dbVar:nssv15151287;dbVar:nssv17970297;dbVar:nssv17970308;dbVar:nssv15146667;dbVar:nssv15154062;dbVar:nssv15134156;dbVar:nssv15146075;dbVar:nssv15119768 1:146053395-249233096;1:177551194-199599056;1:179002041-199694025;1:179011315-199022759;1:179073387-200192265;1:179413480-201764737;1:189003615-199584994;1:195089819-197443021;1:195483440-197865624;1:196712877-196797546;1:196722207-196808505 0.04;0.20;0.21;0.22;0.20;0.19;0.41;1.83;1.81;48.80;49.91 DDD:3693 1:196724161-196912840 0.1822 1000g;DDD:3692;DDD:3693;DDD:3695;dgv11e55;dgv6e203;dgv87e199;esv2421560;esv3588469;nsv514031;nsv517662 1:196711068-196937536;1:196719268-196810043;1:196722346-196822692;1:196723048-196815791;1:196724161-196912840;1:196727851-196939719;1:196728878-196808865;1:196728878-196808865;1:196731149-196901753;1:196733402-196813850;1:196738898-196801697 0.4486 1:196779204-196779204 1000g;1:196792551-196801251 DDD:3714;1:196724161-196912840 DDD:3693 1:196761371-196761371 1000g;1:196780929-196780929 1000g;1:196748312-196757828 DDD:3701 1:196772366-196774588 esv3588475;1:196782000-196788000 gnomAD-SV_v2.1_DEL_1_10685;1:196748312-196757828 DDD:3701;1:196785120-196821192 DDD:3712;1:196711068-196937536 nsv517662;1:196722346-196822692 dgv87e199;1:196724161-196912840 DDD:3693;1:196728878-196808865 1000g;1:196729000-196789200 gnomAD-SV_v2.1_DEL_1_10680;1:196733402-196813850 DDD:3695;1:196735896-196764940 esv3588471;1:196738898-196801697 nsv514031;1:196777327-196902217 DDD:3707;1:196782356-196903873 esv3588478 1:196772366-196774588 1000g;1:196772800-196779400 gnomAD-SV_v2.1_DEL_1_10684;1:196798566-196802072 DDD:3720;1:196772602-196794300 DDD:3705;1:196790200-196805500 gnomAD-SV_v2.1_DEL_1_10686;1:196719268-196810043 DDD:3692;1:196723048-196815791 esv2421560;1:196727851-196939719 dgv6e203;1:196728878-196808865 esv3588469;1:196731149-196901753 dgv11e55;1:196735896-196764940 1000g;1:196738624-196771280 DDD:3698;1:196773003-196909196 DDD:3706;1:196782356-196903873 1000g 1057190;1061944;1065487;2085508 gain 0.350 0.285 1:196797933-196799242 L1MDa 1:196756102-196796319 1:196796320-196825045 98.26 1.07662990621103 1.30887789301822 134371;605336 yes 8 2.6297e-08 9.0932e-04 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (2 genes, +0.00);5F (+0.00) 5 -1_196756232_196799302_DEL_1 1 196756232 196799302 -43070 DEL Benign NA split q31.3 CFHR1 NM_002113 196788860 196801319 10442 607 61 yes 6 txStart-intron4 5'UTR-CDS 327 3' 196788860 196799302 DDD:3693 1:196724161-196912840 0.1822 1000g;DDD:3692;DDD:3693;DDD:3695;DDD:3706;DDD:3707;DDD:3712;dgv11e55;dgv6e203;dgv87e199;esv2421560;esv3588469;esv3588478;nsv514031;nsv517662 1:196785120-196821192;1:196711068-196937536;1:196719268-196810043;1:196722346-196822692;1:196723048-196815791;1:196724161-196912840;1:196727851-196939719;1:196728878-196808865;1:196728878-196808865;1:196731149-196901753;1:196733402-196813850;1:196738898-196801697;1:196773003-196909196;1:196777327-196902217;1:196782356-196903873;1:196782356-196903873 0.4486 1061944 gain 92.58 1.07662990621103 1.30887789301822 dense deposit disease;hemolytic uremic syndrome, atypical, susceptibility to, 1 AD;AR Limited;Supportive 23728178[PMID] 134371 (Hemolytic uremic syndrome, atypical, susceptibility to), 235400 (3) AR,AD;(Macular degeneration, age-related, reduced risk of), 603075 (3) AD AD;AR,AD yes 8 2.6297e-08 9.0932e-04 full=5 -1_196756232_196799302_DEL_1 1 196756232 196799302 -43070 DEL Benign NA split q31.3 CFHR3 NM_021023 196743969 196764537 8306 563 56 yes 6 intron3-txEnd CDS-3'UTR 1114 3' 196756231 196764537 DDD:3693 1:196724161-196912840 0.1822 1000g;DDD:3692;DDD:3693;DDD:3695;DDD:3698;dgv11e55;dgv6e203;dgv87e199;esv2421560;esv3588469;esv3588471;gnomAD-SV_v2.1_DEL_1_10680;nsv514031;nsv517662 1:196711068-196937536;1:196719268-196810043;1:196722346-196822692;1:196723048-196815791;1:196724161-196912840;1:196727851-196939719;1:196728878-196808865;1:196728878-196808865;1:196729000-196789200;1:196731149-196901753;1:196733402-196813850;1:196735896-196764940;1:196735896-196764940;1:196738624-196771280;1:196738898-196801697 0.4486 98.26 0.6684477327677 0.697024247535932 605336 (Hemolytic uremic syndrome, atypical, susceptibility to), 235400 (3) AR,AD;(Macular degeneration, age-related, reduced risk of), 603075 (3) AD AD;AR,AD yes 8 1.7200e-11 1.2190e-05 full=5 -12_63935482_64130626_DEL_1 12 63935482 64130626 -195144 DEL DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA full q14.2 DPY19L2 1 RXYLT1 (morbid/RE=GH_Enhancer);TBK1 (morbid/RE=EA_enhancer) Spermatogenic failure 9, 613958 (3) AR dbVar:nssv15119764;dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63952694-64062354;12:63989747-63989817 dbVar:nssv15161620;dbVar:nssv15161414;nssv15161422;dbVar:nssv15171852;dbVar:nssv15161798;dbVar:nssv15171855 12:2-133851895;12:173788-133777902;12:191620-133777645;12:282466-133773393;12:621221-133779118 0.15;0.15;0.15;0.15;0.15 dbVar:nssv15136921 12:61300933-66961857 3.45 1 Spermatogenic_failure_9 12:64020291-64020367 DDD:38896;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 esv3629757;12:63949898-63949980 gnomAD-SV_v2.1_DUP_12_34998;12:64069043-64136500 dgv280e214;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888 12:63949898-63949980 gnomAD-SV_v2.1_DUP_12_34998;12:64069043-64136500 dgv280e214;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888;12:64020291-64020367 DDD:38896;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 esv3629757 12:63950173-63950264 CMRI:1_pbsv.DEL.823;12:63946730-63946956 esv2662353;12:63946730-63946956 CMRI:1_pbsv.DEL.822_duplicate1;12:63950173-63950264 CMRI:1_pbsv.DEL.823;12:63946730-63946956 esv2662353;12:63946730-63946956 CMRI:1_pbsv.DEL.822_duplicate1 12:63950172-63950241 gnomAD-SV_v2.1_DEL_12_129266;12:64020291-64020367 DDD:38896;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265;12:63950172-63950241 gnomAD-SV_v2.1_DEL_12_129266;12:64020291-64020367 DDD:38896;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265 1054499;1054500;1087307;119292;1194770;1209828;1267803;1328263;1491350;1619448;174035;1760195;1881832;1883558;2089432;2353750;2419380;2692928;2792491;2814116;2850280;287527;2965163;31158;350981;693309;981327 gain;loss 0.530 0.430 12:63935369-63935656 AluSq2 12:64130409-64130696 AluSq2 12:63923419-63951619 12:64119249-64146247 81.13 1.02618176351368 1.66555804568279 613893 yes 4 1.0936e-13 7.0294e-05 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (1 gene, +0.00);5F (+0.00) 5 -12_63935482_64130626_DEL_1 12 63935482 64130626 -195144 DEL DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA split q14.2 DPY19L2 NM_173812 63952692 64062273 109581 2277 100 no 22 txStart-txEnd 5'UTR-3'UTR 63952692 64062273 Spermatogenic failure 9, 613958 (3) AR dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63989747-63989817 1 Spermatogenic_failure_9 1000g;DDD:38888;esv3629757;gnomAD-SV_v2.1_DUP_12_34997 12:63936386-64131550;12:63939159-64117235;12:63939159-64117235;12:63940549-64135811 0.0257 1054499;1054500;1267803;1760195 gain;loss 81.13 1.02618176351368 1.66555804568279 male infertility due to globozoospermia;spermatogenic failure 9 AR Strong;Supportive 21397063;21397063[PMID]_22571172[PMID];21397064 613893 Spermatogenic failure 9, 613958 (3) AR AR yes 4 1.0936e-13 7.0294e-05 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA full p12 CDRT15;CDRT3;CDRT4;CDRT7;CDRT8;COX10;HS3ST3B1;LOC101928475;MGC12916;MIR4731;PMP22;TEKT3;TVP23C;TVP23C-CDRT4 14 ABCG8 (morbid/RE=mTL_miRNA);ACBD5 (morbid/RE=mTL_miRNA);ACVRL1 (HI=3/morbid/RE=mTL_miRNA);AMH (morbid/RE=mTL_miRNA);ANKS6 (morbid/RE=mTL_miRNA);ATL3 (morbid/RE=mTL_miRNA);C12orf65 (morbid/RE=mTL_miRNA);CABP4 (morbid/RE=mTL_miRNA);CACNA1C (morbid/RE=mTL_miRNA);CAVIN1 (morbid/RE=mTL_miRNA);CD4 (morbid/RE=mTL_miRNA);CDT1 (morbid/RE=mTL_miRNA);CEP104 (morbid/RE=mTL_miRNA);CHD7 (HI=3/morbid/RE=mTL_miRNA);CHST6 (morbid/RE=mTL_miRNA);CISD2 (morbid/RE=mTL_miRNA);CPT1A (morbid/RE=mTL_miRNA);CREB1 (morbid/RE=mTL_miRNA);CRIPT (morbid/RE=mTL_miRNA);CYB5A (morbid/RE=mTL_miRNA);CYCS (morbid/RE=mTL_miRNA);DNAJB13 (morbid/RE=mTL_miRNA);DNAL1 (morbid/RE=mTL_miRNA);EIF2B2 (morbid/RE=mTL_miRNA);EMC1 (morbid/RE=mTL_miRNA);FANCA (morbid/RE=mTL_miRNA);GAN (morbid/RE=mTL_miRNA);GATAD2B (HI=3/morbid/RE=mTL_miRNA);GNB5 (morbid/RE=mTL_miRNA);HCFC1 (morbid/RE=mTL_miRNA);HCN4 (morbid/RE=mTL_miRNA);HFE (morbid/RE=mTL_miRNA);IKBKG (HI=3/morbid/RE=mTL_miRNA);IRAK4 (morbid/RE=mTL_miRNA);ISCA2 (morbid/RE=mTL_miRNA);KCND3 (morbid/RE=mTL_miRNA);KCNH2 (HI=3/morbid/RE=mTL_miRNA);KDM6B (morbid/RE=mTL_miRNA);KIAA1549 (morbid/RE=mTL_miRNA);LDHD (morbid/RE=mTL_miRNA);LIAS (morbid/RE=mTL_miRNA);LNPK (morbid/RE=mTL_miRNA);LRTOMT (morbid/RE=mTL_miRNA);MAP2K2 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MFSD2A (morbid/RE=mTL_miRNA);MVK (morbid/RE=mTL_miRNA);MYH9 (morbid/RE=mTL_miRNA);MYO1C (morbid/RE=mTL_miRNA);MYO6 (morbid/RE=mTL_miRNA);MYPN (morbid/RE=mTL_miRNA);NACC1 (morbid/RE=mTL_miRNA);NECTIN1 (morbid/RE=mTL_miRNA);NEK8 (morbid/RE=mTL_miRNA);NKAP (morbid/RE=mTL_miRNA);PAX3 (HI=3/morbid/RE=mTL_miRNA);PDE6D (morbid/RE=mTL_miRNA);PDHB (morbid/RE=mTL_miRNA);PEX6 (morbid/RE=mTL_miRNA);PIGL (morbid/RE=GH_Enhancer+GH_Promoter/Enhancer);PIGO (morbid/RE=mTL_miRNA);PLAA (morbid/RE=mTL_miRNA);PLPBP (morbid/RE=mTL_miRNA);POLR3A (morbid/RE=mTL_miRNA);PRIM1 (morbid/RE=mTL_miRNA);PTGIS (morbid/RE=mTL_miRNA);RMND1 (morbid/RE=mTL_miRNA);ROBO2 (morbid/RE=mTL_miRNA);RS1 (HI=3/morbid/RE=mTL_miRNA);RTN2 (morbid/RE=mTL_miRNA);SBF1 (morbid/RE=mTL_miRNA);SDHAF1 (morbid/RE=mTL_miRNA);SHOC2 (morbid/RE=mTL_miRNA);SIK1 (morbid/RE=mTL_miRNA);SLC12A6 (morbid/RE=mTL_miRNA);SLC1A4 (morbid/RE=mTL_miRNA);SLC25A15 (morbid/RE=mTL_miRNA);SLC27A4 (morbid/RE=mTL_miRNA);SLC30A2 (morbid/RE=mTL_miRNA);SOS1 (morbid/RE=mTL_miRNA);SPTA1 (morbid/RE=mTL_miRNA);SPTLC2 (morbid/RE=mTL_miRNA);TAOK1 (morbid/RE=mTL_miRNA);THRA (morbid/RE=mTL_miRNA);THSD4 (morbid/RE=mTL_miRNA);TIMM8A (HI=3/morbid/RE=mTL_miRNA);TLR7 (morbid/RE=mTL_miRNA);TMEM127 (HI=3/RE=mTL_miRNA);TMEM43 (morbid/RE=mTL_miRNA);TNRC6B (HI=3/morbid/RE=mTL_miRNA);TPM2 (morbid/RE=mTL_miRNA);TRIOBP (morbid/RE=mTL_miRNA);TTC19 (morbid/RE=EA_enhancer);TTF2 (morbid/RE=mTL_miRNA);TUBB4A (morbid/RE=mTL_miRNA);VDR (morbid/RE=mTL_miRNA);VPS53 (morbid/RE=mTL_miRNA);WDR73 (morbid/RE=mTL_miRNA);ZSWIM7 (morbid/RE=GH_Enhancer) Charcot-Marie-Tooth_disease,_type_IA CLN:965414;dbVar:nssv15123319;dbVar:nssv15123460;dbVar:nssv15124534;dbVar:nssv15130870;dbVar:nssv15132574;nssv15139980;nssv16091758;dbVar:nssv15143888;dbVar:nssv15144711;dbVar:nssv15605910;dbVar:nssv15770494;dbVar:nssv15770609;dbVar:nssv15770794;dbVar:nssv16216948;dbVar:nssv17171394;dbVar:nssv17171395;dbVar:nssv17171396;dbVar:nssv17517518;dbVar:nssv17968761;dbVar:nssv17971796 17:14104013-15422557;17:14111773-15442066;17:14139890-15406546;17:14413313-15169915;17:15036413-15036413;17:15036413-15067411;17:15132095-15169674;17:15133085-15164054;17:15133095-15164078;17:15133097-15165152;17:15133098-15164054;17:15133961-15169915;17:15134215-15162530;17:15134215-15164064;17:15134229-15164050;17:15134234-15164044;17:15134235-15164044;17:15142779-15164054;17:15162412-15406546 ?Neuropathy, inflammatory demyelinating, 139393 (3) ?AD;Charcot-Marie-Tooth disease, type 1A, 118220 (3) AD;Charcot-Marie-Tooth disease, type 1E, 118300 (3) AD;Dejerine-Sottas disease, 145900 (3) AR,AD;Neuropathy, recurrent, with pressure palsies, 162500 (3) AD;Roussy-Levy syndrome, 180800 (3) AD HI3:PMP22;dbVar:nssv15119700;nssv15120161;dbVar:nssv15123358;dbVar:nssv15124100;dbVar:nssv15124536;dbVar:nssv15130148;nssv15131578;dbVar:nssv15131641;dbVar:nssv15132056;dbVar:nssv15133540;dbVar:nssv15152434;dbVar:nssv15605873;dbVar:nssv15770639;dbVar:nssv16212046;dbVar:nssv16213644;dbVar:nssv17171685;dbVar:nssv17171686;dbVar:nssv17171687;dbVar:nssv17517519;dbVar:nssv17968760;dbVar:nssv17971249;dbVar:nssv17971279;dbVar:nssv17972656;dbVar:nssv17974454;dbVar:nssv17974892;morbid:PMP22 17:14110044-14111913;17:14111773-15442066;17:14128551-15422557;17:14139890-15142928;17:14215740-15422582;17:14763747-15242181;17:15133085-15134407;17:15133085-15142938;17:15133085-15164054;17:15133095-15164078;17:15133095-15168690;17:15133098-15164054;17:15133961-15169915;17:15134215-15164064;17:15134234-15164044;17:15134235-15164044;17:15138536-15168643;17:15142769-15142948;17:15142779-15142938;17:15142779-15164054;17:15142930-15164044;17:15152792-15162532;17:15162402-15162520;17:15162402-15162523;17:15162402-15164054 17p12 recurrent (HNPP/CMT1A) region (includes PMP22) dbVar:nssv15148946;dbVar:nssv15150353;dbVar:nssv15149908;nssv15152170;dbVar:nssv15159024;dbVar:nssv15160732;dbVar:nssv15159027;dbVar:nssv15121114;dbVar:nssv15133502;dbVar:nssv15605908;dbVar:nssv17955950;dbVar:nssv15127850;dbVar:nssv15155527;dbVar:nssv16215327;dbVar:nssv15152221;dbVar:nssv15155528;dbVar:nssv15152212;dbVar:nssv15151828;dbVar:nssv15138362;dbVar:nssv15152433;dbVar:nssv15141972;dbVar:nssv15137438;dbVar:nssv15138198;dbVar:nssv15151261;dbVar:nssv15152245;dbVar:nssv15139258;nssv15130449;dbVar:nssv15133504;dbVar:nssv15138548;dbVar:nssv15133503;dbVar:nssv17976450;dbVar:nssv17955866;TS3:ISCA-37436;dbVar:nssv17649964;dbVar:nssv15123339;dbVar:nssv15141042;dbVar:nssv15122626;dbVar:nssv16867389;dbVar:nssv15140957;dbVar:nssv15141757;dbVar:nssv15123522;dbVar:nssv15159072;dbVar:nssv15605912;dbVar:nssv15137903;dbVar:nssv15123444;dbVar:nssv16207305;dbVar:nssv15136705;dbVar:nssv15134920;dbVar:nssv15132415;dbVar:nssv15133505 17:526-14667519;17:526-15027737;17:527-81041938;17:7215-81058310;17:8548-81060040;17:12345-81057996;17:10795577-17867596;17:14029614-15562901;17:14063252-15449627;17:14073285-15442296;17:14073604-15482773;17:14076431-15491532;17:14079631-15370444;17:14083055-15463054;17:14083055-15479940;17:14083055-15491532;17:14083055-15491533;17:14083055-15567669;17:14085653-15512120;17:14087934-15437330;17:14087934-15484358;17:14087934-15484858;17:14087934-15490100;17:14087934-15491532;17:14087934-15500645;17:14090301-15467184;17:14090301-15473590;17:14090301-15482240;17:14093319-15476314;17:14096090-15492591;17:14097916-15422952;17:14098197-15442500;17:14098278-15471179;17:14098661-15501133;17:14099743-15471179;17:14100119-15455297;17:14100119-15458649;17:14100119-15492400;17:14100119-15492444;17:14101030-15504740;17:14105875-15611546;17:14111773-15482872;17:14139858-15707850;17:14195643-15545880;17:15093601-15856310;17:15113718-18184130;17:15138003-20524013;17:15162482-20828612 3.87;6.17;1.66;1.66;1.66;1.66;18.98;87.52;96.80;98.02;95.23;94.83;98.41;97.24;96.07;95.28;95.28;90.39;94.07;99.10;96.10;96.06;95.71;95.61;94.99;97.46;97.01;96.41;97.03;96.09;99.83;99.82;97.75;95.68;97.85;99.02;98.78;96.38;96.38;95.54;88.74;97.02;83.05;92.31;45.69;10.69;5.65;4.93 17p12 recurrent (HNPP/CMT1A) region (includes PMP22);Mitochondrial complex IV deficiency, nuclear type 3, 619046 (3) AR morbid:COX10;dbVar:nssv15129689;dbVar:nssv15145216;dbVar:nssv15138335;dbVar:nssv15145035;dbVar:nssv15141682;dbVar:nssv15141099;dbVar:nssv15138794;dbVar:nssv15137498;nssv15155529;dbVar:nssv15137504;dbVar:nssv15141647;HI3:ISCA-37436;dbVar:nssv15150275;dbVar:nssv15129116;dbVar:nssv15123772;dbVar:nssv15141918;dbVar:nssv15159071;nssv15605909;dbVar:nssv15123331;dbVar:nssv15605911;dbVar:nssv15605913;dbVar:nssv16255829;dbVar:nssv15136096;dbVar:nssv15136245;dbVar:nssv15126994;dbVar:nssv15134560;dbVar:nssv15137984 17:13972821-14111994;17:14073604-15482773;17:14082226-15421861;17:14083055-15475087;17:14086859-15476561;17:14087788-15473312;17:14087788-15483608;17:14087788-15490100;17:14087934-15484858;17:14087934-15491532;17:14095640-15274712;17:14097916-15422952;17:14098661-15500645;17:14098787-15495266;17:14099743-15471179;17:14100119-15455238;17:14101030-15449627;17:14101030-15482817;17:14104013-15551814;17:14110452-15449097;17:14111755-15442178;17:14111773-15482872;17:14111773-15491748;17:14112032-15482773;17:14574436-15856310;17:14970117-17375771 8.53;95.23;98.66;96.40;96.56;96.85;96.14;95.70;96.06;95.61;99.62;99.83;95.72;96.10;97.85;99.03;99.44;97.05;92.42;99.47;99.99;97.02;96.40;97.03;67.68;19.62 39 Charcot-Marie-Tooth_disease;Charcot-Marie-Tooth_disease,_type_I;Charcot-Marie-Tooth_disease,_type_IA;Charcot-Marie-Tooth_disease_type_1E;Charcot-Marie-Tooth_disease_type_2E;Cytochrome-c_oxidase_deficiency_disease;Dejerine-Sottas_disease;Dejerine-Sottas_syndrome,_autosomal_dominant;Hereditary_liability_to_pressure_palsies;Inborn_genetic_diseases;Mitochondrial_complex_4_deficiency,_nuclear_type_3;Roussy-Lévy_syndrome 17:14191081-14191901 DDD:48801;17:14417929-14417929 1000g;17:14817895-14817895 1000g;17:15106636-15106636 1000g;17:15417589-15417589 1000g;17:14224375-14483419 1000g;17:14668590-15084842 1000g; 17:14175896-14175896 1000g;17:14191081-14198547 DDD:48802;17:14527655-14527655 1000g;17:15043041-15043041 1000g;17:15350668-15350668 1000g;17:14135250-14141000 gnomAD-SV_v2.1_DUP_17_43571;17:14224375-14483419 esv3640026;17:14668590-15084842 esv3640046 17:14189911-14191555 esv2665541;17:14189911-14191557 1000g;17:14190834-14191460 nsv574421;17:14189911-14191555 CMRI:2_pbsv.DEL.554_duplicate11;17:14240923-14242032 1000g;17:14240941-14242023 gnomAD-SV_v2.1_DEL_17_158742;17:14332272-14332576 gnomAD-SV_v2.1_DEL_17_158748;17:14445418-14445481 CMRI:0_pbsv.DEL.395_duplicate6;17:14685631-14685891 CMRI:2_pbsv.DEL.564_duplicate10;17:15046092-15048186 1000g;17:15183453-15185715 1000g;17:15183459-15185724 dgv537e199;17:15183464-15185724 DDD:48818;17:15368432-15368610 gnomAD-SV_v2.1_DEL_17_158824;17:15043086-15058720 gnomAD-SV_v2.1_DEL_17_158796;17:15043706-15058719 esv3640059;17:15043902-15058720 DDD:48812;17:15043927-15058236 esv2422017;17:15119957-15126208 DDD:48816; 17:14189911-14191555 DDD:48799;17:14189911-14191555 gnomAD-SV_v2.1_DEL_17_158736;17:14189911-14191557 esv3640023;17:14191081-14191901 DDD:48801;17:14240918-14242023 DDD:48803;17:14240923-14242032 esv3640027;17:14240918-14242023 CMRI:4_pbsv.DEL.505_duplicate6;17:14332365-14332556 CMRI:46_pbsv.DEL.455_duplicate3;17:14685553-14685604 CMRI:3_pbsv.DEL.512_duplicate9;17:14685640-14685691 CMRI:10_pbsv.DEL.361_duplicate9;17:15046092-15048186 esv3640060;17:15183453-15185715 esv3640065;17:15183463-15185695 gnomAD-SV_v2.1_DEL_17_158812;17:15183459-15185695 CMRI:47_pbsv.DEL.524_duplicate8;17:15368415-15368610 CMRI:22_pbsv.DEL.521_duplicate13;17:15043706-15058719 1000g;17:15043901-15058720 gnomAD-SV_v2.1_DEL_17_158797;17:15043902-15058721 dgv536e199;17:15044000-15058236 esv3892962;17:15268963-15271981 DDD:48821 1070158;1222619;125750;1562489;1565970;156941;16261;162997;162998;162999;1646965;1711416;1824525;1878175;189357;19160;1950846;1993654;2029269;25493;2560430;262086;262087;2716613;271780;271781;271782;271783;271784;271793;271794;2830900;288724;298188;2999357;301045;301046;304081;304086;306277;3092357;313230;323830;323831;342512;342513;345937;353055;363528;384357;39252;... gain;loss 0.505 0.420 17:15422954-15470900 3 96.58 -2.62354415217069 -0.276965016632095 -1.64032033771268 3.6772325764896 4.17517843763452 602125;601097 yes yes 1 9.0958e-01 8.3315e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_gain_source, +1.00);2H-2 (PMP22, +0.00);2J (COX10, +0.00);2L (TVP23C/TVP23C-CDRT4, +0.00);3A (14 genes, +0.00);5F (+0.00) 5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT15 NM_001007530 14138989 14140179 1190 567 100 no 3 txStart-txEnd 5'UTR-3'UTR 14138989 14140179 gnomAD-SV_v2.1_DUP_17_43571 17:14135250-14141000 0.0839 96.58 -2.62354415217069 -2.20416703243077 -2.47162789907313 1.67462394349301 1.73432863871862 9 1.2820e-06 7.5064e-03 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT3 NR_146601 15373624 15374150 526 0 0 no 1 txStart-txEnd UTR 15373624 15374150 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT4 NM_001204477 15339331 15370935 31604 459 100 no 4 txStart-txEnd 5'UTR-3'UTR 15339331 15370935 86.77 -2.62354415217069 -2.24141606178004 -2.47162789907313 -0.193191475026352 0.152950560142403 9 9.5789e-02 2.4429e-01 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT7 NR_033371 14934291 14935274 983 0 0 no 3 txStart-txEnd UTR 14934291 14935274 1000g;esv3640046 17:14668590-15084842;17:14668590-15084842 0.2720 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT8 NR_103559 15008301 15009504 1203 0 0 no 2 txStart-txEnd UTR 15008301 15009504 1000g;esv3640046 17:14668590-15084842;17:14668590-15084842 0.2720 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 COX10 NM_001303 13972820 14111994 11876 404 30 yes 7 intron6-txEnd CDS-3'UTR 4580 5' 14100118 14111994 dbVar:nssv15124536 17:14110044-14111913 1 Cytochrome-c_oxidase_deficiency_disease;Mitochondrial_complex_4_deficiency,_nuclear_type_3 30 60.22 -2.62354415217069 -2.20885612270982 -2.47162789907313 0.16322796385632 0.511864222455301 Leigh syndrome;cytochrome-c oxidase deficiency disease;mitochondrial complex 4 deficiency, nuclear type 3 AR Definitive;Moderate;Strong;Supportive 10767350;10767350[PMID]_12928484[PMID]_15455402[PMID];12928484;15455402 602125 Mitochondrial complex IV deficiency, nuclear type 3, 619046 (3) AR AR yes 3 8.4050e-02 6.4657e-01 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 HS3ST3B1 NM_006041 14204397 14252721 48324 1173 100 no 2 txStart-txEnd 5'UTR-3'UTR 14204397 14252721 1070158;271783;288724;429012;470190 gain;loss 42.95 -2.62354415217069 -0.276965016632095 -1.64032033771268 3.6772325764896 4.17517843763452 4 2.9349e-01 8.5455e-02 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 LOC101928475 NR_135638 14918121 14955592 37471 0 0 no 2 txStart-txEnd UTR 14918121 14955592 1000g;esv3640046 17:14668590-15084842;17:14668590-15084842 0.2720 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 MGC12916 NR_026880 14207056 14209062 2006 0 0 no 1 txStart-txEnd UTR 14207056 14209062 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 MIR4731 NR_039884 15154943 15155013 70 0 0 no 1 txStart-txEnd UTR 15154943 15155013 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 PMP22 NM_000304 15133095 15168643 35548 483 100 no 5 txStart-txEnd 5'UTR-3'UTR 15133095 15168643 dbVar:nssv15130870;dbVar:nssv15770494;dbVar:nssv15770609;dbVar:nssv15770794;dbVar:nssv17171395;dbVar:nssv17171396;dbVar:nssv17517518;dbVar:nssv17971796 17:15133097-15165152;17:15133098-15164054;17:15134215-15162530;17:15134215-15164064;17:15134229-15164050;17:15134234-15164044;17:15134235-15164044;17:15142779-15164054 ?Neuropathy, inflammatory demyelinating, 139393 (3) ?AD;Charcot-Marie-Tooth disease, type 1A, 118220 (3) AD;Charcot-Marie-Tooth disease, type 1E, 118300 (3) AD;Dejerine-Sottas disease, 145900 (3) AR,AD;Neuropathy, recurrent, with pressure palsies, 162500 (3) AD;Roussy-Levy syndrome, 180800 (3) AD dbVar:nssv15119700;nssv15120161;dbVar:nssv15131641;dbVar:nssv15133540;dbVar:nssv15770639;dbVar:nssv16212046;dbVar:nssv17171685;dbVar:nssv17171686;dbVar:nssv17171687;dbVar:nssv17517519;dbVar:nssv17968760;dbVar:nssv17971279;dbVar:nssv17974892;morbid:PMP22 17:15133098-15164054;17:15134215-15164064;17:15134234-15164044;17:15134235-15164044;17:15138536-15168643;17:15142769-15142948;17:15142779-15142938;17:15142779-15164054;17:15142930-15164044;17:15152792-15162532;17:15162402-15162520;17:15162402-15162523;17:15162402-15164054 38 Charcot-Marie-Tooth_disease;Charcot-Marie-Tooth_disease,_type_I;Charcot-Marie-Tooth_disease,_type_IA;Charcot-Marie-Tooth_disease_type_1E;Charcot-Marie-Tooth_disease_type_2E;Dejerine-Sottas_disease;Dejerine-Sottas_syndrome,_autosomal_dominant;Hereditary_liability_to_pressure_palsies;Inborn_genetic_diseases;Roussy-Lévy_syndrome 342512;740803 gain;loss 3 0 40.48 -2.62354415217069 -1.55852578268999 -2.47162789907313 -0.424806725478425 1.07197498670855 Charcot-Marie-Tooth disease type 1A;Charcot-Marie-Tooth disease type 1E;Charcot-Marie-Tooth disease type 3;hereditary neuropathy with liability to pressure palsies AD Definitive;Moderate;Supportive 10330345;12578939;18698610[PMID]_12090401[PMID];20301384[PMID];8355122;NULL 601097 ?Neuropathy, inflammatory demyelinating, 139393 (3) ?AD;Charcot-Marie-Tooth disease, type 1A, 118220 (3) AD;Charcot-Marie-Tooth disease, type 1E, 118300 (3) AD;Dejerine-Sottas disease, 145900 (3) AR,AD;Neuropathy, recurrent, with pressure palsies, 162500 (3) AD;Roussy-Levy syndrome, 180800 (3) AD ?AD;AD;AR,AD yes yes 1 9.0958e-01 8.3315e-01 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 TEKT3 NM_031898 15207128 15244914 37786 1473 100 no 9 txStart-txEnd 5'UTR-3'UTR 15207128 15244914 54646;740806;740807;740808;740809;740810 gain;loss 59.06 -2.62354415217069 -1.25885348060374 -2.47162789907313 0.241972873531725 -0.405588628410555 7 1.9845e-17 3.1995e-14 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 TVP23C NM_145301 15405577 15466945 36489 369 44 no 6 intron5-txEnd CDS-3'UTR 7032 5' 15405577 15442066 49.2 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.622094281610252 0.322678575541803 7 2.3189e-05 1.3674e-04 full=5 -17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 TVP23C-CDRT4 NM_001204478 15339331 15466797 102735 33 6 no 7 intron5-txEnd CDS-3'UTR 7032 5' 15339331 15442066 1562489;1878175;1950846;1993654;323831;39252 gain;loss 52.33 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.433099426603836 0.962176598220999 7 8.7378e-07 2.3623e-03 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA full p14.2-p14.1 ADAMTS9;ADAMTS9-AS1;ADAMTS9-AS2;ATXN7;C3orf49;LINC00698;LINC00994;PRICKLE2;PRICKLE2-AS1;PRICKLE2-AS2;PRICKLE2-AS3;PSMD6;PSMD6-AS2;SCAANT1;SNTN;SYNPR;SYNPR-AS1;THOC7;THOC7-AS1 19 Spinocerebellar ataxia 7, 164500 (3) AD morbid:ATXN7 3:63953470-63989136 dbVar:nssv15162889;dbVar:nssv15164144;dbVar:nssv15149891;nssv15151839 3:60175-197948027;3:61496-197838262;3:61893-197851986 1.18;1.18;1.18 dbVar:nssv15146214;dbVar:nssv15774780;dbVar:nssv15148889;dbVar:nssv15147494;dbVar:nssv17956097;dbVar:nssv16207905;dbVar:nssv15150232;dbVar:nssv15146193;dbVar:nssv15120308 3:54079046-66046136;3:57076137-65716956;3:57174453-90309110;3:57416266-64870197;3:59332509-70686155;3:60449668-65561638;3:60526227-63742930;3:61956522-68514983;3:64746925-78459248 19.47;26.96;7.03;25.91;20.52;45.57;24.99;35.52;3.81 2 Epilepsy,_progressive_myoclonic_5;See_cases 3:63209013-63209013 1000g;3:63725720-63725786 gnomAD-SV_v2.1_DUP_3_8770;3:64218944-64218944 1000g;3:64399232-64399232 1000g;3:64606110-64606110 1000g;3:64986948-64986948 1000g; 3:63141366-63142666 gnomAD-SV_v2.1_DUP_3_8762;3:63540966-63540966 1000g;3:63725722-63725778 CMRI:23_pbsv.INS.DUP.757_duplicate1;3:64363176-64363234 gnomAD-SV_v2.1_DUP_3_8775;3:64533160-64535613 gnomAD-SV_v2.1_DUP_3_8779;3:64658686-64658756 gnomAD-SV_v2.1_DUP_3_8780;3:65089127-65089191 gnomAD-SV_v2.1_DUP_3_8786 3:63128000-63139500 gnomAD-SV_v2.1_DEL_3_33027;3:63134848-63135305 esv3596388;3:63134857-63135309 esv2677248;3:63134857-63135309 CMRI:34_pbsv.DEL.767_duplicate1;3:63184387-63184462 CMRI:11_pbsv.DEL.1276_duplicate2;3:63299366-63299509 CMRI:2_pbsv.DEL.901_duplicate2;3:63299485-63299620 CMRI:0_pbsv.DEL.680_duplicate1;3:63390589-63391286 1000g;3:63581434-63581503 CMRI:0_pbsv.DEL.683_duplicate2;3:63736259-63738398 DDD:10459;3:63779698-63780276 gnomAD-SV_v2.1_DEL_3_33056;3:63802474-63803919 DDD:10462;3:64253006-64253304 CMRI:74_pbsv.DEL.716_duplicate1;3:64914570-64914754 gnomAD-SV_v2.1_DEL_3_33102;3:65117754-65119706 esv3596414;3:65117794-65119665 esv2670508;3:65123005-65123504 DDD:10471;3:65123011-65123543 1000g;3:65117794-65119665 CMRI:4_pbsv.DEL.1166_duplicate2;3:65179629-65179678 CMRI:3_pbsv.DEL.1150_duplicate1;3:65185850-65210363 dgv1383e212... 3:63104370-63107212 1000g;3:63134848-63135305 1000g;3:63134857-63135309 DDD:10454;3:63134857-63135309 gnomAD-SV_v2.1_DEL_3_33028;3:63184318-63184367 CMRI:1_pbsv.DEL.709_duplicate2;3:63256544-63256649 CMRI:2_pbsv.DEL.898_duplicate2;3:63299381-63299448 CMRI:51_pbsv.DEL.908_duplicate2;3:63299571-63299670 CMRI:11_pbsv.DEL.1283_duplicate2;3:63461917-63461985 CMRI:3_pbsv.DEL.1123_duplicate1;3:63617835-63617951 CMRI:13_pbsv.DEL.1014_duplicate1;3:63764517-63764572 CMRI:3_pbsv.DEL.1133_duplicate2;3:63779975-63780276 1000g;3:64253006-64253304 1000g;3:64914567-64914754 1000g;3:65117754-65119706 1000g;3:65117794-65119665 DDD:10470;3:65123004-65123504 gnomAD-SV_v2.1_DEL_3_33116;3:65123005-65123504 esv2672642;3:65123011-65123543 esv3596415;3:65123005-65123504 CMRI:6_pbsv.DEL.1126_duplicate3;3:65179920-65212596 nsv516641... 1001471;1001472;1006251;1006472;1006476;1010057;1011896;1011897;1023308;1023309;1034893;1038175;1038178;1038179;1042029;1042030;1042031;1042032;1042033;1048425;1048426;1048427;1048428;1048429;1048432;1048433;1048434;1048435;1048436;1049414;1067782;1067783;1068008;1068009;1068010;1068049;1068051;1068055;1072114;107667;107668;107669;107670;1087679;1109537;1117462;1135088;1135553;1138223;1156484;1167330;... gain;loss 0.355 0.430 3:62939271-62939427 MER5A1 3:65268746-65268796;3:65268797-65269299 LTR16B;L1MB2 68.54 0.730304227093642 1.22944963357105 1.15014257139245 0.85336181383742 2.61388539526619 607640 yes 0 9.9544e-01 9.8784e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (19 genes, +0.00);5F (+0.00) 5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ADAMTS9 NM_182920 64501330 64673676 172346 5808 100 no 40 txStart-txEnd 5'UTR-3'UTR 64501330 64673676 1042031;1042032;1042033;1067782;1068009;1072114;1135553;1504208;1511158;1799872;1915647;1932599;1967350;2001537;2005149;2044109;2044804;2075783;2144978;2203224;2240649;2308508;2593226;2599590;2691373;2694024;276109;276110;2792679;2823064;2845215;2969713;301933;366448;549355;571129;592200;726177;787948;944263;944306;947661;947689;969017;970694;970756;970760;984390 gain;loss 31.58 -1.39811826175974 -0.477054147176997 -0.711187689176027 -0.797615479905467 0.510431064472241 nephronophthisis 1 AR Supportive 30609407[PMID] 1 1.0004e-06 4.2266e-07 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ADAMTS9-AS1 NR_110150 64547021 64575760 28739 0 0 no 3 txStart-txEnd UTR 64547021 64575760 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ADAMTS9-AS2 NR_038264 64670545 64997146 326601 0 0 no 6 txStart-txEnd UTR 64670545 64997146 787949 loss full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ATXN7 NM_001177387 63884074 63989136 105062 2838 100 no 13 txStart-txEnd 5'UTR-3'UTR 63884074 63989136 Spinocerebellar ataxia 7, 164500 (3) AD morbid:ATXN7 3:63953470-63989136 1038179;107668;418781;447003;447603;59834;708951;708952;708953;708954;708955 gain;loss 17.72 0.730304227093642 0.636006512326363 0.862222958307612 0.85336181383742 0.386394557252369 spinocerebellar ataxia type 7 AD Moderate;Supportive 20301317[PMID] 607640 Spinocerebellar ataxia 7, 164500 (3) AD AD yes 1 9.5950e-01 9.2856e-01 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 C3orf49 NM_001355236 63804974 63834312 29338 879 100 no 7 txStart-txEnd 5'UTR-3'UTR 63804974 63834312 68.54 7 4.0628e-08 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 LINC00698 NR_027104 63088363 63110737 22374 0 0 no 7 txStart-txEnd UTR 63088363 63110737 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 LINC00994 NR_033978 64064036 64073039 9003 0 0 no 4 txStart-txEnd UTR 64064036 64073039 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2 NM_001370528 64077911 64253849 175938 2535 100 no 8 txStart-txEnd 5'UTR-3'UTR 64077911 64253849 2 Epilepsy,_progressive_myoclonic_5;See_cases 1231659;1243506;135466;135902;135909;1751877;1788970;1904984;1922947;2321740;2731090;2731929;276100;276101;276102;2849960;3074273;448792;483530;483531;518859;518860;733817;770227;770228;770229;770230;770231;770232;940486 gain;loss 19.72 0.557303960601498 1.22944963357105 1.15014257139245 0.337534415605819 2.61388539526619 1 9.9544e-01 9.8784e-01 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2-AS1 NR_045697 64053639 64088807 35168 0 0 no 3 txStart-txEnd UTR 64053639 64088807 276099;309182;448792 gain;loss full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2-AS2 NR_046701 64089145 64092034 2889 0 0 no 4 txStart-txEnd UTR 64089145 64092034 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2-AS3 NR_046702 64173219 64187236 14017 0 0 no 4 txStart-txEnd UTR 64173219 64187236 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PSMD6 NM_001271779 63996224 64009282 13058 1329 100 no 9 txStart-txEnd 5'UTR-3'UTR 63996224 64009282 8.63 0.167507008532066 0.979835184836382 0.835574002005388 -0.764855351937167 1.81088903222596 0 9.9518e-01 9.6209e-01 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PSMD6-AS2 NR_038286 63989697 63997917 8220 0 0 no 3 txStart-txEnd UTR 63989697 63997917 447005 loss full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 SCAANT1 NR_148359 63897193 63897448 255 0 0 no 1 txStart-txEnd UTR 63897193 63897448 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 SNTN NM_001348756 63638350 63650883 12533 534 100 no 5 txStart-txEnd 5'UTR-3'UTR 63638350 63650883 309180 loss 66.14 0.0947592166796515 -0.338299474644844 -0.173049359454575 -0.0258588646723899 -1.1196806141136 9 1.0257e-04 2.7379e-03 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 SYNPR NM_001130003 63263983 63602600 338617 858 100 no 6 txStart-txEnd 5'UTR-3'UTR 63263983 63602600 1011896;1048425;1048426;1048427;1048428;1048429;1048432;1048433;1048434;1048435;1087679;1109537;1117462;1135088;1138223;1156484;1167330;1167547;1168860;1175015;1254249;1266934;1290237;1308427;1311785;1353672;1363891;1401634;1425273;1426934;1438065;1484968;1501941;1501972;1522150;1569690;1601924;1607649;1615745;1649298;1715877;1750926;1759407;1790646;1796017;1797559;1797796;1826000;1866248;1867896;1886977;... gain;loss 27.35 -0.433167561551584 -0.551647400212283 4 4.1913e-03 1.7171e-01 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 SYNPR-AS1 NR_046677 63409271 63535727 126456 0 0 no 5 txStart-txEnd UTR 63409271 63535727 1048428;1048429;1048432;1167330;2255770;2744480;3073085;327622;494779;494780;548375;726165;726166;770204;770205;830151;89973;90090 gain;loss full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 THOC7 NM_025075 63819545 63849481 29936 615 100 no 8 txStart-txEnd 5'UTR-3'UTR 63819545 63849481 770220 loss 7.39 0.226822637024357 -2.4455441384945 -1.79937886551949 -0.696357556154856 1.21996216564798 4 6.0818e-03 9.7832e-01 full=5 -3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 THOC7-AS1 NR_104326 63846320 63847495 1175 0 0 no 2 txStart-txEnd UTR 63846320 63847495 full=5 -3_97483034_97487074_DEL_1 3 97483034 97487074 -4040 DEL BBS3/ARL6 promotor overlapped Pathogenic NA full q11.2 ARL6 1 dbVar:nssv16214088 3:97486953-97487074 dbVar:nssv15162889;dbVar:nssv15164144;dbVar:nssv15149891;nssv15151839;dbVar:nssv17976063;dbVar:nssv15148953;dbVar:nssv15148997 3:60175-197948027;3:61496-197838262;3:61893-197851986;3:72488758-99614758;3:93519465-145413168;3:93538468-103607593 0.00;0.00;0.00;0.01;0.01;0.04 Bardet-Biedl syndrome 3, 600151 (3) AR;Retinitis pigmentosa 55, 613575 (3) AR;Bardet-Biedl syndrome 1, modifier of, 209900 (3) AR,Digenic recessive dbVar:nssv15147282;dbVar:nssv15146259;dbVar:nssv16254235;dbVar:nssv17171854;morbid:ARL6;dbVar:nssv17975034;dbVar:nssv17971170 3:93538468-116605903;3:93605516-122935530;3:95563097-102371126;3:97194197-97510809;3:97483602-97520073;3:97486953-97487094;3:97486953-97516893 0.02;0.01;0.06;1.28;9.52;85.92;0.41 4 Bardet-Biedl_syndrome_1;Bardet-Biedl_syndrome_3;Retinitis_pigmentosa;Retinitis_pigmentosa_55 0.455 0.335 10.16 0.309918017790144 -0.416168538751037 -0.151628993663861 -0.139439307213778 -0.254839803839483 608845 yes yes 5 1.0130e-02 4.2709e-03 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (1 gene, +0.00);5F (+0.00) 5 -3_97483034_97487074_DEL_1 3 97483034 97487074 -4040 DEL BBS3/ARL6 promotor overlapped Pathogenic NA split q11.2 ARL6 NM_032146 97483364 97520086 3710 123 21 no 9 txStart-intron3 5'UTR-CDS 0 5' 97483364 97487074 dbVar:nssv16214088 3:97486953-97487074 4 Bardet-Biedl_syndrome_1;Bardet-Biedl_syndrome_3;Retinitis_pigmentosa;Retinitis_pigmentosa_55 30 0 10.16 0.309918017790144 -0.416168538751037 -0.151628993663861 -0.139439307213778 -0.254839803839483 Bardet-Biedl syndrome;Bardet-Biedl syndrome 3;retinitis pigmentosa;retinitis pigmentosa 55 AD;AR Definitive;Strong;Supportive 10973238;10973251;11381270;11567139;12016587;12118255;12524598;12567324;12837689;14520415;15137946;15314642;16308660;16380913;16582908;16606853;17160889;18203199;18327255;19956407;20301537[PMID];20301590[PMID];20618352;20671153;20805367;21937992;22353939;7711739;7987310;8298649;9714014 608845 Bardet-Biedl syndrome 3, 600151 (3) AR;Retinitis pigmentosa 55, 613575 (3) AR;(Bardet-Biedl syndrome 1, modifier of), 209900 (3) AR,Digenic recessive AR;AR,Digenic recessive yes yes 5 1.0130e-02 4.2709e-03 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA full q14.3 ADGRV1;ARRDC3;ARRDC3-AS1;CETN3;LINC01339;LOC731157;LUCAT1;LYSMD3;MBLAC2;MIR3660;POLR3G 11 AGO2 (morbid/RE=mTL_miRNA);B4GALNT1 (morbid/RE=mTL_miRNA);CEP57 (morbid/RE=mTL_miRNA);EPHA2 (morbid/RE=mTL_miRNA);GFPT1 (morbid/RE=mTL_miRNA);GPSM2 (morbid/RE=mTL_miRNA);KDM6A (HI=3/morbid/RE=mTL_miRNA);KMT2A (HI=3/morbid/RE=mTL_miRNA);MEF2C (HI=3/morbid/RE=GH_Enhancer);MSX2 (morbid/RE=mTL_miRNA);NODAL (morbid/RE=mTL_miRNA);PIGS (morbid/RE=mTL_miRNA);PLEKHM1 (morbid/RE=mTL_miRNA);PPP1R15B (morbid/RE=mTL_miRNA);PRKACB (morbid/RE=mTL_miRNA);SELENOI (morbid/RE=mTL_miRNA) dbVar:nssv17172150;dbVar:nssv17172151;dbVar:nssv17974002;dbVar:nssv17974003 5:89920928-89923613;5:89938434-89948400;5:89938454-89949769;5:90144435-90159694 ?Febrile seizures, familial, 4, 604352 (3) AD;Usher syndrome, type 2C, 605472 (3) Digenic dominant,AR;Usher syndrome, type 2C, GPR98;PDZD7 digenic, 605472 (3) Digenic dominant,AR dbVar:nssv15120153;dbVar:nssv15132320;dbVar:nssv15222969;dbVar:nssv15771046;dbVar:nssv15772847;nssv15776039;dbVar:nssv15774334;dbVar:nssv16211859;dbVar:nssv16213434;dbVar:nssv17171561;dbVar:nssv17171562;dbVar:nssv17171563;dbVar:nssv17955830;dbVar:nssv17955831;dbVar:nssv17970856;dbVar:nssv17971694;dbVar:nssv17972093;dbVar:nssv17972414;dbVar:nssv17974150;dbVar:nssv17975051;dbVar:nssv8639335;dbVar:nssv8639887;morbid:ADGRV1 5:89523964-90412409;5:89854614-90460254;5:89910547-90079868;5:89940238-89999954;5:89940571-89940765;5:89953723-89954095;5:89968364-90111553;5:89988605-90077246;5:89989688-90000325;5:89990520-90136394;5:89992735-90125023;5:90015866-90016040;5:90112103-90219415;5:90119223-90151738;5:90150020-90159573;5:90151539-90151738;5:90221275-90357290;5:90261233-90398157;5:90261233-90678909;5:90281162-90281339;5:90368245-90398177;5:90368250-90459732 CLN:1393621;CLN:1447486;dbVar:nssv17971430;dbVar:nssv17974885 5:89949103-89949102;5:89949103-89949236;5:89990260-89990259;5:89990260-89990371 dbVar:nssv15164761;dbVar:nssv15164765;dbVar:nssv15151111;nssv15151221;dbVar:nssv16206767;dbVar:nssv15120567;dbVar:nssv15132159;dbVar:nssv15142272;dbVar:nssv15151420;dbVar:nssv15135062;dbVar:nssv16207624;dbVar:nssv15776426 5:13649-180905029;5:25329-180693344;5:113578-180719789;5:72790062-97478870;5:73459012-110145153;5:86420656-92718726;5:86621338-89204392;5:87399002-92675748;5:87493550-92528869;5:87792845-109221844;5:89949119-129317455 1.67;1.68;1.68;12.26;8.25;48.08;16.65;57.39;60.14;14.13;4.71 dbVar:nssv15151179;dbVar:nssv17970035;dbVar:nssv15138006;dbVar:nssv15127576;dbVar:nssv15120741;dbVar:nssv15122759;dbVar:nssv15143209;nssv17976344;dbVar:nssv15133640;dbVar:nssv15140345;dbVar:nssv15132311;dbVar:nssv15167313;dbVar:nssv15121450;dbVar:nssv15142367;dbVar:nssv15132971;dbVar:nssv15133836;dbVar:nssv15121948;dbVar:nssv15132637;dbVar:nssv15121951;dbVar:nssv15138054;dbVar:nssv15120743;dbVar:nssv15139660;dbVar:nssv8639414;dbVar:nssv15138098;dbVar:nssv15152898 5:17628742-176575720;5:82185952-90110454;5:83899399-110770779;5:85045626-89302638;5:86039541-91633081;5:86062777-91444662;5:86400001-154000000;5:86487716-89253266;5:86530416-88893604;5:86672701-100860147;5:87512315-95096562;5:87664107-91698938;5:87764486-90147447;5:88016215-88783092;5:88062498-89028098;5:88232588-93437723;5:88348148-88783092;5:88377170-104022949;5:89670424-127412115;5:90682370-97701584;5:90707526-130655256;5:91064111-93896378;5:91327087-93283043;5:91504102-104858348 1.91;16.86;11.27;12.41;51.11;49.62;4.48;17.32;5.05;21.34;39.93;72.48;57.62;1.14;26.28;58.17;2.01;19.35;5.65;15.96;2.74;26.07;24.30;2.23 182 Ear_malformation;Febrile_seizures,_familial,_4;Hearing_impairment;Rare_genetic_deafness;Retinal_dystrophy;Usher_syndrome;Usher_syndrome_type_2;Usher_syndrome_type_2C 5:89264627-89264683 gnomAD-SV_v2.1_DUP_5_15710;5:89450782-89450782 1000g;5:89671041-89671041 1000g;5:89860422-89860742 1000g;5:90178738-90178738 1000g;5:90674000-90680000 gnomAD-SV_v2.1_DUP_5_15729;5:90866987-90867072 gnomAD-SV_v2.1_DUP_5_15730;5:91031027-91031027 1000g; 5:88804381-88804381 1000g;5:89378369-89378369 1000g;5:89450998-89450998 1000g;5:89851863-89851863 1000g;5:89997835-89997835 1000g;5:90574109-90575794 gnomAD-SV_v2.1_DUP_5_15725;5:90819292-90819292 1000g;5:90866989-90867067 CMRI:12_pbsv.INS.DUP.1494;5:91771267-91771267 1000g 5:89003716-89004039 1000g;5:89003721-89004043 esv2657768;5:89737801-89740342 gnomAD-SV_v2.1_DEL_5_59998;5:89796389-89797983 DDD:17944;5:89860422-89860742 1000g;5:89860422-89860742 CMRI:0_pbsv.DEL.1202_duplicate3;5:89890975-89891198 CMRI:4_pbsv.DEL.1782_duplicate3;5:89993274-89993331 gnomAD-SV_v2.1_DEL_5_60008;5:89993275-89993331 CMRI:12_pbsv.DEL.1484_duplicate1;5:90141990-90142107 CMRI:214_pbsv.DEL.1534_duplicate3;5:90499768-90502128 1000g;5:90499775-90502095 gnomAD-SV_v2.1_DEL_5_60035;5:90499773-90502095 CMRI:0_pbsv.DEL.1209_duplicate3;5:90574694-90574986 CMRI:0_pbsv.DEL.1211_duplicate2;5:90615256-90617038 gnomAD-SV_v2.1_DEL_5_60039;5:90624229-90626177 DDD:17956;5:91071145-91072339 DDD:17965;5:91409746-91409809 CMRI:0_pbsv.DEL.1216_duplicate4;5:91480768-91481128 esv2670356;5:91546064-91548437 DDD:17971;5:91597356-91600865 1000g... 5:89003565-89004043 gnomAD-SV_v2.1_DEL_5_59965;5:89003716-89004039 esv3605750;5:89003721-89004039 CMRI:4_pbsv.DEL.1772_duplicate2;5:89737813-89740394 1000g;5:89809934-89813189 DDD:17945;5:89860435-89860742 gnomAD-SV_v2.1_DEL_5_60002;5:89890931-89891478 CMRI:32_pbsv.DEL.1542;5:89891294-89891518 CMRI:4_pbsv.DEL.1783_duplicate1;5:89993275-89993331 1000g;5:89997834-89998478 gnomAD-SV_v2.1_DEL_5_60009;5:90178737-90179245 gnomAD-SV_v2.1_DEL_5_60015;5:90499768-90502128 esv3605774;5:90500494-90502051 nsv598934;5:90574694-90574986 esv2667050;5:90615214-90617038 DDD:17953;5:90615264-90617030 1000g;5:90624258-90626177 1000g;5:91409760-91409810 gnomAD-SV_v2.1_DEL_5_60071;5:91445000-91451000 gnomAD-SV_v2.1_DEL_5_60074;5:91480775-91481128 CMRI:0_pbsv.DEL.1220_duplicate1;5:91547162-91547229 CMRI:2_pbsv.DEL.1597_duplicate1... 1012046;1012047;1012048;1012293;1030337;1030338;1033529;1042268;1045022;1048899;1048901;1048903;1048904;1048905;1048906;1048908;1048909;1048910;1048912;1049414;1050026;1050069;1129390;1159;116747;1167734;1184520;1235286;1261013;1328155;135611;1369917;1370909;1453730;1472404;1506541;1521205;1591506;161012;1627766;1667822;1701297;1743351;1832039;186491;187745;187747;1883320;1888140;1896842;1919311;... gain;loss 0.335 0.275 5:91802185-91802338 L2a 38.97 0.855259196084686 1.02927857149332 1.26063232799998 1.13380694792028 1.83366808117122 602851 yes yes 1 9.8715e-01 9.7875e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (11 genes, +0.00);5F (+0.00) 5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 ADGRV1 NM_032119 89854613 90460254 605641 18921 100 no 90 txStart-txEnd 5'UTR-3'UTR 89854613 90460254 dbVar:nssv17172150;dbVar:nssv17172151;dbVar:nssv17974002;dbVar:nssv17974003 5:89920928-89923613;5:89938434-89948400;5:89938454-89949769;5:90144435-90159694 ?Febrile seizures, familial, 4, 604352 (3) AD;Usher syndrome, type 2C, 605472 (3) Digenic dominant,AR;Usher syndrome, type 2C, GPR98;PDZD7 digenic, 605472 (3) Digenic dominant,AR dbVar:nssv15120153;dbVar:nssv15222969;dbVar:nssv15771046;dbVar:nssv15772847;nssv15776039;dbVar:nssv15774334;dbVar:nssv16213434;dbVar:nssv17171561;dbVar:nssv17171562;dbVar:nssv17171563;dbVar:nssv17955830;dbVar:nssv17955831;dbVar:nssv17970856;dbVar:nssv17971694;dbVar:nssv17972093;dbVar:nssv17972414;dbVar:nssv17974150;dbVar:nssv17975051;dbVar:nssv8639335;dbVar:nssv8639887;morbid:ADGRV1 5:89854614-90460254;5:89910547-90079868;5:89940238-89999954;5:89940571-89940765;5:89953723-89954095;5:89968364-90111553;5:89988605-90077246;5:89989688-90000325;5:89990520-90136394;5:89992735-90125023;5:90015866-90016040;5:90112103-90219415;5:90119223-90151738;5:90150020-90159573;5:90151539-90151738;5:90221275-90357290;5:90261233-90398157;5:90281162-90281339;5:90368245-90398177;5:90368250-90459732 CLN:1393621;CLN:1447486;dbVar:nssv17971430;dbVar:nssv17974885 5:89949103-89949102;5:89949103-89949236;5:89990260-89990259;5:89990260-89990371 182 Ear_malformation;Febrile_seizures,_familial,_4;Hearing_impairment;Rare_genetic_deafness;Retinal_dystrophy;Usher_syndrome;Usher_syndrome_type_2;Usher_syndrome_type_2C 1012047;1030337;1030338;1033529;1048904;1048905;1048906;1048908;1048909;1129390;1167734;1184520;1235286;1369917;1370909;1453730;1472404;1506541;1591506;1627766;1667822;1743351;1832039;186491;1919311;1919485;1996536;2100188;2114593;213805;2227613;2294896;2411628;2485541;2521190;2533050;2587397;278132;278133;2806466;2857514;298920;2991366;299426;299474;3092210;32373;32374;332918;344762;412573;... gain;loss 30 0 25.58 Usher syndrome type 2;Usher syndrome type 2C;febrile seizures, familial, 4;nonsyndromic genetic hearing loss AD;AR Definitive;Disputed Evidence;Limited;Strong;Supportive 14740321;20301515[PMID];22147658;25572244 602851 ?Febrile seizures, familial, 4, 604352 (3) AD;Usher syndrome, type 2C, 605472 (3) Digenic dominant,AR;Usher syndrome, type 2C, GPR98/PDZD7 digenic, 605472 (3) Digenic dominant,AR AD;Digenic dominant,AR yes yes full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 ARRDC3 NM_020801 90664447 90679134 14687 1245 100 no 8 txStart-txEnd 5'UTR-3'UTR 90664447 90679134 10.63 0.745040589608255 1.00834122048279 1.19108832249232 0.196967347879621 1.83366808117122 1 9.8715e-01 9.7875e-01 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 ARRDC3-AS1 NR_027435 90676163 90716532 40369 0 0 no 3 txStart-txEnd UTR 90676163 90716532 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 CETN3 NM_001297765 89689151 89705603 16452 576 100 no 6 txStart-txEnd 5'UTR-3'UTR 89689151 89705603 5.94 0.855259196084686 1.02927857149332 1.26063232799998 -1.0886019180172 0.322004765294048 7 1.0528e-04 1.1321e-02 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LINC01339 NR_120601 89454155 89585888 131733 0 0 no 6 txStart-txEnd UTR 89454155 89585888 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LOC731157 NR_105024 89705816 89706486 670 0 0 no 2 txStart-txEnd UTR 89705816 89706486 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LUCAT1 NR_103548 90598802 90610219 11417 0 0 no 5 txStart-txEnd UTR 90598802 90610219 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LYSMD3 NM_198273 89811444 89825401 13957 921 100 no 3 txStart-txEnd 5'UTR-3'UTR 89811444 89825401 28.58 0.0616099264393714 -0.398837217747125 3 3.0382e-01 7.7182e-01 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 MBLAC2 NM_203406 89754025 89770588 16563 840 100 no 2 txStart-txEnd 5'UTR-3'UTR 89754025 89770588 38.68 -0.0315707309390069 0.414676882744812 0.420940108293089 1.13380694792028 0.9911283716698 7 4.5418e-05 2.8010e-04 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 MIR3660 NR_037433 89312437 89312537 100 0 0 no 1 txStart-txEnd UTR 89312437 89312537 full=5 -5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 POLR3G NM_001370354 89769745 89810372 40627 672 100 no 8 txStart-txEnd 5'UTR-3'UTR 89769745 89810372 38.97 0.478729015674934 0.798950378312061 0.929744998199481 0.494543657071353 -0.512733755306802 8 1.7611e-10 6.4276e-05 full=5 -6_29854871_29896710_DEL_1 6 29854871 29896710 -41839 DEL Benign NA full p22.1 HCG4B;HLA-H 2 ZFP57 (morbid/RE=EA_enhancer+GH_Enhancer+GH_Promoter/Enhancer) Hemochromatosis, 235200 (3) AR;Transferrin serum level QTL2, 614193 (3);Alzheimer disease, susceptibility to, 104300 (3) AD;Microvascular complications of diabetes 7, 612635 (3);Porphyria cutanea tarda, susceptibility to, 176100 (3) AR,AD;Porphyria variegata, susceptibility to, 176200 (3) AD morbid:HLA-H 6:29855350-29858856 dbVar:nssv15166690;dbVar:nssv15166692;dbVar:nssv15161578;dbVar:nssv15161859;nssv15161868;dbVar:nssv15168255;dbVar:nssv15148873;dbVar:nssv15606075 6:60108-171054786;6:108667-170980171;6:156975-46757028;6:156976-170919482;6:165633-170919470;6:3224545-30624967;6:29455466-81447367 0.02;0.02;0.09;0.02;0.02;0.15;0.08 dbVar:nssv17955655 6:28005013-31683185 1.14 DDD:20149 6:29840747-29917149 0.0264 1000g;DDD:20139;DDD:20142;DDD:20149;DDD:20154;dgv1087e199;dgv7e195;esv2761013;esv2763941;esv3608493 6:29745199-29961072;6:29805446-29928380;6:29836637-29921127;6:29837073-29937311;6:29840747-29917149;6:29842746-29916111;6:29851173-29904515;6:29851173-29904515;6:29851444-29899493;6:29853315-29914786 0.4519 6:29840747-29917149 DDD:20149 6:29892873-29892873 1000g 6:29863776-29863891 CMRI:28_pbsv.DEL.669_duplicate2;6:29851444-29865718 esv2422126;6:29891102-29906000 DDD:20157;6:29745199-29961072 DDD:20139;6:29836637-29921127 esv2763941;6:29840747-29917149 DDD:20149;6:29851173-29904515 1000g;6:29851444-29899493 dgv7e195;6:29859518-29886164 dgv740n27;6:29864510-29936194 dgv1734e212; 6:29863594-29863680 CMRI:0_pbsv.DEL.480_duplicate2;6:29829109-29874629 dgv1726e212;6:29890896-29906192 dgv1089e199;6:29892561-29905834 HI40:ISCA-46607;6:29805446-29928380 DDD:20142;6:29837073-29937311 esv2761013;6:29842746-29916111 dgv1087e199;6:29851173-29904515 esv3608493;6:29853315-29914786 DDD:20154;6:29864510-29889669 dgv1732e212;6:29873934-29890069 nsv515032 0.375 0.510 6:29842025-29863148 613609 yes yes 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (2 genes, +0.00);5F (+0.00) 5 -6_29854871_29896710_DEL_1 6 29854871 29896710 -41839 DEL Benign NA split p22.1 HCG4B NR_001317 29892368 29894992 2624 0 0 no 1 txStart-txEnd UTR 29892368 29894992 DDD:20149 6:29840747-29917149 0.0264 1000g;DDD:20139;DDD:20142;DDD:20149;DDD:20154;DDD:20157;dgv1087e199;dgv1089e199;dgv1734e212;dgv7e195;esv2761013;esv2763941;esv3608493 6:29890896-29906192;6:29891102-29906000;6:29745199-29961072;6:29805446-29928380;6:29836637-29921127;6:29837073-29937311;6:29840747-29917149;6:29842746-29916111;6:29851173-29904515;6:29851173-29904515;6:29851444-29899493;6:29853315-29914786;6:29864510-29936194 0.4519 full=5 -6_29854871_29896710_DEL_1 6 29854871 29896710 -41839 DEL Benign NA split p22.1 HLA-H NR_001434 29855349 29858856 3507 0 0 no 8 txStart-txEnd UTR 29855349 29858856 Hemochromatosis, 235200 (3) AR;Transferrin serum level QTL2, 614193 (3);Alzheimer disease, susceptibility to, 104300 (3) AD;Microvascular complications of diabetes 7, 612635 (3);Porphyria cutanea tarda, susceptibility to, 176100 (3) AR,AD;Porphyria variegata, susceptibility to, 176200 (3) AD morbid:HLA-H 6:29855350-29858856 DDD:20149 6:29840747-29917149 0.0264 1000g;DDD:20139;DDD:20142;DDD:20149;DDD:20154;dgv1087e199;dgv1726e212;dgv7e195;esv2422126;esv2761013;esv2763941;esv3608493 6:29829109-29874629;6:29851444-29865718;6:29745199-29961072;6:29805446-29928380;6:29836637-29921127;6:29837073-29937311;6:29840747-29917149;6:29842746-29916111;6:29851173-29904515;6:29851173-29904515;6:29851444-29899493;6:29853315-29914786 0.4519 613609 Hemochromatosis, 235200 (3) AR;[Transferrin serum level QTL2], 614193 (3);(Alzheimer disease, susceptibility to), 104300 (3) AD;(Microvascular complications of diabetes 7), 612635 (3);(Porphyria cutanea tarda, susceptibility to), 176100 (3) AR,AD;(Porphyria variegata, susceptibility to), 176200 (3) AD AD;AR;AR,AD yes yes full=5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA full q12.1 CERNA3;CHCHD7;MOS;PLAG1;RPS20;SNORD54 6 Adenomas, salivary gland pleomorphic, somatic, 181030 (3);Silver-Russell syndrome 4, 618907 (3) AD morbid:PLAG1 8:57073468-57123832 dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161801;nssv15777239;dbVar:nssv15161417;nssv15161657;dbVar:nssv15161846;dbVar:nssv15169210;dbVar:nssv15161105;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161087;dbVar:nssv15161426;dbVar:nssv15161357;dbVar:nssv15777249;dbVar:nssv15147495;dbVar:nssv15774700;dbVar:nssv15161758;dbVar:nssv15161797;dbVar:nssv15139743;dbVar:nssv15135704 8:10214-146293414;8:13939-146304022;8:158049-146295771;8:158050-146295771;8:158992-146280828;8:164985-146293414;8:176453-146294098;8:191531-146274835;8:191531-146280020;8:191606-146280167;8:12491000-146295771;8:21149034-146295771;8:31936552-146295771;8:36437622-60531557;8:39555658-64049089;8:46942957-70216022;8:46942963-140297737;8:53436132-65195953;8:56228415-65864987 0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.14;0.15;0.16;0.76;0.75;0.79;0.20;1.56;1.90 dbVar:nssv15167540;dbVar:nssv15148967;dbVar:nssv15138741;dbVar:nssv15125104;dbVar:nssv15137960;dbVar:nssv15137390;dbVar:nssv15121489;dbVar:nssv15124419 8:49822484-58822602;8:50384338-58738029;8:54237950-62775577;8:54407102-58403572;8:55677511-57697858;8:55733918-62058861;8:56335974-59749312;8:56405321-57358911 2.04;2.20;2.15;4.59;9.09;2.90;5.38;19.25 8:57048633-57098412 1000g 8:57161907-57161907 1000g 8:56988709-56997905 gnomAD-SV_v2.1_DEL_8_92763;8:56988763-56997935 1000g;8:57017202-57017670 CMRI:271_pbsv.DEL.1055_duplicate5 8:56988698-56989817 1000g;8:56988746-56989825 DDD:27790;8:56988706-56997914 CMRI:30_pbsv.DEL.1508_duplicate5 227414;227459;259626;280931;280932;282047;282072;302857;302858;303092;303101;303169;303182;303196;303201;312032;312165;312226;312239;335198;335303;335354;376852;376955;376962;376972;376977;394952;394953;395216;469505;471349;484667;534473;534774;534866;558558;564747;571930;575671;580548;589430;681488;777179;848459;855820 gain;loss 0.410 0.330 8:57169736-57169990 AluSz6 78.38 0.98432298330431 0.46663829854876 0.586548999968454 2.2343517715388 2.48184869967673 603026 yes 0 9.9532e-01 8.2992e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (6 genes, +0.00);5F (+0.00) 5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 CERNA3 NR_149110 56987150 56987833 683 0 0 no 2 txStart-txEnd UTR 56987150 56987833 full=5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 CHCHD7 NM_001011668 57124196 57131357 7161 333 100 no 5 txStart-txEnd 5'UTR-3'UTR 57124196 57131357 47.62 0.447428062348521 0.400234098889925 0.586548999968454 -0.725400991144389 -0.857804306808559 6 3.4885e-02 3.8798e-01 full=5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 MOS NM_005372 57025500 57026541 1041 1041 100 no 1 txStart-txEnd 5'UTR-3'UTR 57025500 57026541 78.38 0.159444434408663 0.46663829854876 0.524682444320288 2.2343517715388 2.48184869967673 3 5.8928e-01 1.4931e-01 full=5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 PLAG1 NM_001114634 57073467 57123832 50365 1503 100 no 4 txStart-txEnd 5'UTR-3'UTR 57073467 57123832 Adenomas, salivary gland pleomorphic, somatic, 181030 (3);Silver-Russell syndrome 4, 618907 (3) AD morbid:PLAG1 8:57073468-57123832 280931;777179 gain 15.18 0.393657994766781 -2.53125239294469 -2.47162789907313 -0.349819812502603 1.96019845356841 603026 Adenomas, salivary gland pleomorphic, somatic, 181030 (3);Silver-Russell syndrome 4, 618907 (3) AD AD yes 0 9.9532e-01 8.2992e-01 full=5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 RPS20 NM_001146227 56979853 56987065 936 177 41 no 6 txStart-intron3 5'UTR-CDS 124 5' 56986129 56987065 29.1 0.98432298330431 -0.0464637247715686 0.36681079114905 -0.0133102053832282 2.09183372030708 Diamond-Blackfan anemia;familial colorectal cancer type X;hereditary nonpolyposis colon cancer AD Limited;Supportive 24941021[PMID];32790018[PMID] 5 2.0686e-02 6.8632e-01 full=5 -8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 SNORD54 NR_002437 56986397 56986460 63 0 0 no 1 txStart-txEnd UTR 56986397 56986460 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA full p11.22 HSD17B10;HUWE1;IQSEC2;KDM5C;MIR6857;MIR98;MIRLET7F2;RIBC1;SMC1A 9 ACADM (morbid/RE=mTL_miRNA);ACTA1 (morbid/RE=mTL_miRNA);ACVR2B (morbid/RE=mTL_miRNA);ADA (morbid/RE=mTL_miRNA);ADGRE2 (morbid/RE=mTL_miRNA);ADGRG1 (morbid/RE=mTL_miRNA);ADH5 (morbid/RE=mTL_miRNA);AGPS (morbid/RE=mTL_miRNA);AK2 (morbid/RE=mTL_miRNA);ALDH1A3 (morbid/RE=mTL_miRNA);ALDH7A1 (morbid/RE=mTL_miRNA);ALG3 (morbid/RE=mTL_miRNA);ALG8 (morbid/RE=mTL_miRNA);AMD1 (morbid/RE=mTL_miRNA);AMMECR1 (morbid/RE=mTL_miRNA);ANKRD11 (HI=3/morbid/RE=mTL_miRNA);ANTXR2 (morbid/RE=mTL_miRNA);AP1S1 (morbid/RE=mTL_miRNA);ARCN1 (HI=3/morbid/RE=mTL_miRNA);ARHGEF18 (morbid/RE=mTL_miRNA);ARID1A (HI=3/morbid/RE=mTL_miRNA);ARID1B (HI=3/morbid/RE=mTL_miRNA);ATL1 (morbid/RE=mTL_miRNA);ATP13A3 (morbid/RE=mTL_miRNA);ATP2A2 (morbid/RE=mTL_miRNA);ATP7B (morbid/RE=mTL_miRNA);ATR (morbid/RE=mTL_miRNA);ATXN2 (morbid/RE=mTL_miRNA);B4GAT1 (morbid/RE=mTL_miRNA);BACH1 (morbid/RE=mTL_miRNA);BCL11A (HI=3/morbid/RE=mTL_miRNA);BCL2 (morbid/RE=mTL_miRNA);BCOR (HI=3/morbid/RE=mTL_miRNA);BNC2 (morbid/RE=mTL_miRNA);C12orf4 (morbid/RE=mTL_miRNA);C3 (morbid/RE=mTL_miRNA);CACNA1C (morbid/RE=mTL_miRNA);CACNB2 (morbid/RE=mTL_miRNA);CALM1 (morbid/RE=mTL_miRNA);CANT1 (morbid/RE=mTL_miRNA);CAPN15 (morbid/RE=mTL_miRNA);CBL (morbid/RE=mTL_miRNA);CCND2 (morbid/RE=mTL_miRNA);CCNF (morbid/RE=mTL_miRNA);CD59 (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CEP120 (morbid/RE=mTL_miRNA);CEP135 (morbid/RE=mTL_miRNA);CHD1 (morbid/RE=mTL_miRNA);CHD4 (morbid/RE=mTL_miRNA);CHD7 (HI=3/morbid/RE=mTL_miRNA);CHRNB1 (morbid/RE=mTL_miRNA);CHST3 (morbid/RE=mTL_miRNA);CKAP2L (morbid/RE=mTL_miRNA);CLP1 (morbid/RE=mTL_miRNA);CNKSR2 (HI=3/morbid/RE=mTL_miRNA);CNNM4 (morbid/RE=mTL_miRNA);COG5 (morbid/RE=mTL_miRNA);COLGALT1 (morbid/RE=mTL_miRNA);COPB2 (morbid/RE=mTL_miRNA);COX6B1 (morbid/RE=mTL_miRNA);CPOX (morbid/RE=mTL_miRNA);CREB1 (morbid/RE=mTL_miRNA);CRTAP (morbid/RE=mTL_miRNA);CRX (morbid/RE=mTL_miRNA);CTNND1 (morbid/RE=mTL_miRNA);CTPS1 (morbid/RE=mTL_miRNA);CTSC (morbid/RE=mTL_miRNA);CYB5R3 (morbid/RE=mTL_miRNA);CYP19A1 (morbid/RE=mTL_miRNA);DDR2 (morbid/RE=mTL_miRNA);DIABLO (morbid/RE=mTL_miRNA);DICER1 (HI=3/morbid/RE=mTL_miRNA);DNA2 (morbid/RE=mTL_miRNA);DNAAF2 (morbid/RE=mTL_miRNA);DNAH9 (morbid/RE=mTL_miRNA);DNAL1 (morbid/RE=mTL_miRNA);DOLK (morbid/RE=mTL_miRNA);DPAGT1 (morbid/RE=mTL_miRNA);DSG2 (morbid/RE=mTL_miRNA);DUSP6 (morbid/RE=mTL_miRNA);DVL3 (morbid/RE=mTL_miRNA);EDA (HI=3/morbid/RE=mTL_miRNA);EDEM3 (morbid/RE=mTL_miRNA);EDN1 (morbid/RE=mTL_miRNA);EIF2S3 (morbid/RE=mTL_miRNA);EIF4A3 (morbid/RE=mTL_miRNA);ELF4 (morbid/RE=mTL_miRNA);EZH2 (morbid/RE=mTL_miRNA);FADS3 (morbid/RE=mTL_miRNA);FAS (morbid/RE=mTL_miRNA);FBXL4 (morbid/RE=mTL_miRNA);FGD1 (HI=3/morbid/RE=GH_Promoter/Enhancer);FKRP (morbid/RE=mTL_miRNA);FLAD1 (morbid/RE=mTL_miRNA);FOXC1 (HI=3/morbid/RE=mTL_miRNA);FXN (morbid/RE=mTL_miRNA);FZD4 (HI=3/morbid/RE=mTL_miRNA);GALC (morbid/RE=mTL_miRNA);GALNT2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GATM (morbid/RE=mTL_miRNA);GBF1 (morbid/RE=mTL_miRNA);GCNT2 (morbid/RE=mTL_miRNA);GDAP2 (morbid/RE=mTL_miRNA);GLMN (HI=3/morbid/RE=mTL_miRNA);GLUL (morbid/RE=mTL_miRNA);GNPTAB (morbid/RE=mTL_miRNA);HMGA2 (morbid/RE=mTL_miRNA);HNRNPDL (morbid/RE=mTL_miRNA);HNRNPU (morbid/RE=mTL_miRNA);HSPD1 (morbid/RE=mTL_miRNA);IFNAR1 (morbid/RE=mTL_miRNA);IFNGR1 (morbid/RE=mTL_miRNA);IGF1 (morbid/RE=mTL_miRNA);IGF1R (morbid/RE=mTL_miRNA);IL21R (morbid/RE=mTL_miRNA);IL2RA (morbid/RE=mTL_miRNA);IL6R (morbid/RE=mTL_miRNA);IMPDH1 (morbid/RE=mTL_miRNA);IQCB1 (morbid/RE=mTL_miRNA);ITGA3 (morbid/RE=mTL_miRNA);ITGB3 (morbid/RE=mTL_miRNA);JAG1 (HI=3/morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNN3 (morbid/RE=mTL_miRNA);KLHL15 (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);KREMEN1 (morbid/RE=mTL_miRNA);LDLR (HI=3/morbid/RE=mTL_miRNA);LGR4 (morbid/RE=mTL_miRNA);LIFR (morbid/RE=mTL_miRNA);LMNB2 (morbid/RE=mTL_miRNA);MAPK1 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MARS2 (morbid/RE=mTL_miRNA);MAX (HI=3/RE=mTL_miRNA);MED13L (HI=3/morbid/RE=mTL_miRNA);MFSD8 (morbid/RE=mTL_miRNA);MITF (HI=3/morbid/RE=mTL_miRNA);MMACHC (morbid/RE=mTL_miRNA);MPL (morbid/RE=mTL_miRNA);MRPS2 (morbid/RE=mTL_miRNA);MSH6 (HI=3/morbid/RE=mTL_miRNA);MSL3 (morbid/RE=mTL_miRNA);MSMO1 (morbid/RE=mTL_miRNA);MYC (morbid/RE=mTL_miRNA);MYH9 (morbid/RE=mTL_miRNA);NAA15 (HI=3/morbid/RE=mTL_miRNA);NAA20 (morbid/RE=mTL_miRNA);NACC1 (morbid/RE=mTL_miRNA);NDUFAF3 (morbid/RE=mTL_miRNA);NFIB (morbid/RE=mTL_miRNA);NFKB2 (morbid/RE=mTL_miRNA);NHLRC2 (morbid/RE=mTL_miRNA);NKX2-1 (morbid/RE=mTL_miRNA);NPR3 (morbid/RE=mTL_miRNA);NR2F2 (morbid/RE=mTL_miRNA);NRAS (morbid/RE=mTL_miRNA);NSD1 (HI=3/morbid/RE=mTL_miRNA);OPA3 (morbid/RE=mTL_miRNA);OSMR (morbid/RE=mTL_miRNA);PAK1 (morbid/RE=mTL_miRNA);PDE4D (morbid/RE=mTL_miRNA);PDGFB (morbid/RE=mTL_miRNA);PDHB (morbid/RE=mTL_miRNA);PDSS1 (morbid/RE=mTL_miRNA);PDZD8 (morbid/RE=mTL_miRNA);PEX11B (morbid/RE=mTL_miRNA);PGK1 (morbid/RE=mTL_miRNA);PHF8 (HI=3/morbid/RE=EA_enhancer+GH_Enhancer+GH_Promoter/Enhancer+mTL_miRNA);PHKA1 (morbid/RE=mTL_miRNA);PICALM (morbid/RE=mTL_miRNA);PIGC (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);PLCG2 (morbid/RE=mTL_miRNA);PLOD2 (morbid/RE=mTL_miRNA);PMPCA (morbid/RE=mTL_miRNA);POLR1D (HI=3/morbid/RE=mTL_miRNA);PPP1R15B (morbid/RE=mTL_miRNA);PTPN14 (morbid/RE=mTL_miRNA);PURA (HI=3/morbid/RE=mTL_miRNA);PUS1 (morbid/RE=mTL_miRNA);PXDN (morbid/RE=mTL_miRNA);PYCR1 (morbid/RE=mTL_miRNA);QDPR (morbid/RE=mTL_miRNA);RAB39B (HI=3/morbid/RE=mTL_miRNA);RAC1 (morbid/RE=mTL_miRNA);RB1CC1 (morbid/RE=mTL_miRNA);RDX (morbid/RE=mTL_miRNA);REL (morbid/RE=mTL_miRNA);RHBDF2 (morbid/RE=mTL_miRNA);RNF13 (morbid/RE=mTL_miRNA);ROR2 (morbid/RE=mTL_miRNA);RORA (morbid/RE=mTL_miRNA);RS1 (HI=3/morbid/RE=mTL_miRNA);SACS (morbid/RE=mTL_miRNA);SALL4 (HI=3/morbid/RE=mTL_miRNA);SAMD9L (morbid/RE=mTL_miRNA);SCD (morbid/RE=mTL_miRNA);SCUBE3 (morbid/RE=mTL_miRNA);SET (morbid/RE=mTL_miRNA);SHOC2 (morbid/RE=mTL_miRNA);SLC10A7 (morbid/RE=mTL_miRNA);SLC11A2 (morbid/RE=mTL_miRNA);SLC17A5 (morbid/RE=mTL_miRNA);SLC19A2 (morbid/RE=mTL_miRNA);SLC19A3 (morbid/RE=mTL_miRNA);SLC25A12 (morbid/RE=mTL_miRNA);SLC25A13 (morbid/RE=mTL_miRNA);SLC33A1 (morbid/RE=mTL_miRNA);SLC5A5 (morbid/RE=mTL_miRNA);SLC5A6 (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SMAD2 (morbid/RE=mTL_miRNA);SMARCA4 (morbid/RE=mTL_miRNA);SMARCAD1 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SOCS1 (morbid/RE=mTL_miRNA);SORD (morbid/RE=mTL_miRNA);SOX4 (morbid/RE=mTL_miRNA);SRCAP (morbid/RE=mTL_miRNA);STAT2 (morbid/RE=mTL_miRNA);STK4 (morbid/RE=mTL_miRNA);STS (HI=3/morbid/RE=mTL_miRNA);STX3 (morbid/RE=mTL_miRNA);SUOX (morbid/RE=mTL_miRNA);SYT1 (morbid/RE=mTL_miRNA);TAB2 (morbid/RE=mTL_miRNA);TBK1 (morbid/RE=mTL_miRNA);TCOF1 (HI=3/morbid/RE=mTL_miRNA);TEAD1 (morbid/RE=mTL_miRNA);TET3 (morbid/RE=mTL_miRNA);TFAP2A (morbid/RE=mTL_miRNA);TG (morbid/RE=mTL_miRNA);TGFBR1 (morbid/RE=mTL_miRNA);TGFBR2 (morbid/RE=mTL_miRNA);TMEM38B (morbid/RE=mTL_miRNA);TMTC3 (morbid/RE=mTL_miRNA);TPP1 (morbid/RE=mTL_miRNA);TRIM71 (morbid/RE=mTL_miRNA);TUBB2A (morbid/RE=mTL_miRNA);TUBB4A (morbid/RE=mTL_miRNA);TWIST1 (HI=3/morbid/RE=mTL_miRNA);TWNK (morbid/RE=mTL_miRNA);VANGL1 (morbid/RE=mTL_miRNA);VCL (morbid/RE=mTL_miRNA);VPS33A (morbid/RE=mTL_miRNA);WARS2 (morbid/RE=mTL_miRNA);WBP11 (morbid/RE=mTL_miRNA);WDR73 (morbid/RE=mTL_miRNA);WNK1 (morbid/RE=mTL_miRNA);WNT10B (morbid/RE=mTL_miRNA);XK (morbid/RE=mTL_miRNA);YARS2 (morbid/RE=mTL_miRNA);ZBTB20 (morbid/RE=mTL_miRNA);ZBTB24 (morbid/RE=mTL_miRNA);ZBTB7A (morbid/RE=mTL_miRNA);ZFHX3 (morbid/RE=mTL_miRNA);ZMPSTE24 (morbid/RE=mTL_miRNA);ZNF644 (morbid/RE=mTL_miRNA) Xp11.22 region (includes HUWE1) TS3:ISCA-46299;dbVar:nssv15147941;dbVar:nssv15147942;dbVar:nssv15161312;nssv15161529;dbVar:nssv15161768 X:53276031-53298472;X:53283514-53325284;X:53363457-53793054;X:53559549-53622547;X:53559733-53790650 Cornelia de Lange syndrome 2, 300590 (3) XLD;Developmental and epileptic encephalopathy 85, with or without midline brain defects, 301044 (3) XLD;HSD10 mitochondrial disease, 300438 (3) XLD;Intellectual developmental disorder, XL 1, 309530 (3) XLD;Intellectual developmental disorder, XL syndromic, Turner type, 309590 (3) XL;Intellectual_disability,_X-linked_1 CLN:1065452;HI3:IQSEC2;HI3:SMC1A;dbVar:nssv15769470;dbVar:nssv16212358;dbVar:nssv16215156;dbVar:nssv17171530;dbVar:nssv17171900;dbVar:nssv17172048;dbVar:nssv17172462;dbVar:nssv17970926;dbVar:nssv17971164;morbid:HSD17B10;morbid:HUWE1;morbid:IQSEC2;morbid:SMC1A X:53253923-53254071;X:53262059-53350522;X:53264077-53264258;X:53264078-53264257;X:53270947-53271111;X:53279442-53280376;X:53295510-53310766;X:53348888-53349736;X:53401070-53449677;X:53401071-53449677;X:53430479-53432101;X:53430479-53442138;X:53448826-53449569;X:53449432-53449549;X:53458209-53461317;X:53559057-53713664 188 Abnormal_heart_valve_morphology;Congenital_muscular_hypertrophy-cerebral_syndrome;Cornelia_de_Lange_syndrome_1;Developmental_and_epileptic_encephalopathy,_85,_with_or_without_midline_brain_defects;Global_developmental_delay;HSD10_mitochondrial_disease;Hirsutism;Hypertonia;Inborn_genetic_diseases;Intellectual_disability;Intellectual_disability,_X-linked_1;Intellectual_disability,_X-linked_syndromic,_Turner_type;Microcephaly;Neurodevelopmental_delay;Progressive_sensorineural_hearing_impairment;SMC1A-related_cohesinopathy;See_cases;Severe_intellectual_deficiency;Syndromic_X-linked_intellectual_disability_Claes-Jensen_type;Undetermined_early-onset_epileptic_encephalopathy X:53478094-53491686 1000g;X:53478192-53491585 gnomAD-SV_v2.1_DEL_X_186301;X:53496417-53499888 1000g;X:53605624-53605848 CMRI:59_pbsv.DEL.619_duplicate4;X:53772357-53778316 gnomAD-SV_v2.1_DEL_X_186314;X:53776864-53777371 nsv515204;X:53800903-53801312 1000g; X:53319072-53320350 1000g;X:53478160-53491616 DDD:57601;X:53481194-53482847 1000g;X:53513576-53513640 gnomAD-SV_v2.1_DEL_X_186307;X:53772345-53778301 1000g;X:53772358-53778316 DDD:57606;X:53792164-53792218 1000g;X:53819548-53820294 1000g 0.420 0.295 X:53250479-53250649 MIRc X:53855851-53856180;X:53856303-53856465 L1MA7;L1MA7 3 75.6 0.807946261414963 9.03470791370173 300256;300697;300522;314690;300040 yes 0 1.0000e+00 1.0000e+00 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_gain_source, +1.00);2H-2 (HSD17B10/HUWE1/IQSEC2/SMC1A, +0.00);2J (KDM5C, +0.00);3A (9 genes, +0.00);5F (+0.00) 5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 HSD17B10 NM_004493 53458208 53461317 3109 786 100 no 6 txStart-txEnd 5'UTR-3'UTR 53458208 53461317 HSD10 mitochondrial disease, 300438 (3) XLD morbid:HSD17B10 X:53458209-53461317 4 HSD10_mitochondrial_disease;Inborn_genetic_diseases;Neurodevelopmental_delay 0 0 21.63 0.807946261414963 2.17074250392365 HSD10 disease, infantile type;HSD10 disease, neonatal type;HSD10 mitochondrial disease;syndromic X-linked intellectual disability type 10 XL;XLR Definitive;Supportive 10521307;12555940;12696021;16148061;22127393[PMID] 300256 HSD10 mitochondrial disease, 300438 (3) XLD XLD yes 1 9.3604e-01 8.8687e-01 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 HUWE1 NM_031407 53559056 53713664 154608 13125 100 no 84 txStart-txEnd 5'UTR-3'UTR 53559056 53713664 dbVar:nssv15161768 X:53559549-53622547 Intellectual developmental disorder, XL syndromic, Turner type, 309590 (3) XL morbid:HUWE1 X:53559057-53713664 10 Global_developmental_delay;Intellectual_disability;Intellectual_disability,_X-linked_syndromic,_Turner_type;Neurodevelopmental_delay 0 0 10.58 -1.65771922174252 9.03470791370173 intellectual disability, X-linked syndromic, Turner type;non-syndromic X-linked intellectual disability;syndromic intellectual disability AD;XL;XLD Definitive;Supportive 18252223;23721686;29180823;29180823[PMID] 300697 Intellectual developmental disorder, XL syndromic, Turner type, 309590 (3) XL XL yes 0 1.0000e+00 1.0000e+00 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 IQSEC2 NM_001111125 53262057 53350548 88491 4467 100 no 15 txStart-txEnd 5'UTR-3'UTR 53262057 53350548 dbVar:nssv15147941;dbVar:nssv15147942 X:53276031-53298472;X:53283514-53325284 Intellectual developmental disorder, XL 1, 309530 (3) XLD;Intellectual_disability,_X-linked_1 CLN:1065452;HI3:IQSEC2;dbVar:nssv17171900;dbVar:nssv17172048;dbVar:nssv17172462;dbVar:nssv17970926;morbid:IQSEC2 X:53262059-53350522;X:53264077-53264258;X:53264078-53264257;X:53270947-53271111;X:53279442-53280376;X:53295510-53310766;X:53348888-53349736 97 Inborn_genetic_diseases;Intellectual_disability;Intellectual_disability,_X-linked_1;Neurodevelopmental_delay;See_cases;Severe_intellectual_deficiency;Undetermined_early-onset_epileptic_encephalopathy 3 0 26.16 -0.257046228208263 4.55717824142058 complex neurodevelopmental disorder;intellectual disability, X-linked 1;non-syndromic X-linked intellectual disability;severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome XL;XLD Definitive;Strong;Supportive 20473311;20473311[PMID];21686261;23674175;23674175[PMID];24306141;25167861;26544041;26733290;26793055;27665735;28295038;28815955;29026562;300522;30206421;30666632;31415821;31490346;31829726 300522 Intellectual developmental disorder, XL 1, 309530 (3) XLD XLD yes 0 9.9998e-01 9.7539e-01 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 KDM5C NM_001353984 53220502 53254604 3951 150 3 no 26 txStart-intron1 5'UTR-CDS 555 3' 53250653 53254604 dbVar:nssv16215156 X:53253923-53254071 4 Syndromic_X-linked_intellectual_disability_Claes-Jensen_type 3 0 11.71 -1.20041549946446 5.44441583895939 X-linked syndromic intellectual disability;syndromic X-linked intellectual disability Claes-Jensen type XL;XLR Definitive;Supportive 10982473;15586325;15586325[PMID];16538222;18203167;18697827;19826449;21575681 314690 Intellectual developmental disorder, XL syndromic, Claes-Jensen type, 300534 (3) XLR XLR yes 0 1.0000e+00 9.9784e-01 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 MIR6857 NR_106916 53432604 53432697 93 0 0 no 1 txStart-txEnd UTR 53432604 53432697 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 MIR98 NR_029513 53583183 53583302 119 0 0 no 1 txStart-txEnd UTR 53583183 53583302 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 MIRLET7F2 NR_029484 53584152 53584235 83 0 0 no 1 txStart-txEnd UTR 53584152 53584235 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 RIBC1 NM_001031745 53449821 53458063 8242 1140 100 no 8 txStart-txEnd 5'UTR-3'UTR 53449821 53458063 75.6 0.80408198011521 0.293719819544616 1 9.8300e-01 9.6626e-01 full=5 -X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 SMC1A NM_006306 53401069 53449603 48534 3702 100 no 25 txStart-txEnd 5'UTR-3'UTR 53401069 53449603 dbVar:nssv15769470;dbVar:nssv16212358;dbVar:nssv17171530;dbVar:nssv17971164 X:53430479-53432101;X:53430479-53442138;X:53448826-53449569;X:53449432-53449549 73 Abnormal_heart_valve_morphology;Congenital_muscular_hypertrophy-cerebral_syndrome;Cornelia_de_Lange_syndrome_1;Developmental_and_epileptic_encephalopathy,_85,_with_or_without_midline_brain_defects;Global_developmental_delay;Hirsutism;Hypertonia;Inborn_genetic_diseases;Intellectual_disability;Microcephaly;Progressive_sensorineural_hearing_impairment;SMC1A-related_cohesinopathy 3 0 14.23 -0.112682658348456 6.67845368195785 Cornelia de Lange syndrome;Cornelia de Lange syndrome 2;atypical Rett syndrome;complex neurodevelopmental disorder AD;XL;XLD Definitive;Supportive 16604071;17273969;20301283[PMID];20635401;22106055;24124034;26354354;28102598;28548707;32222533[PMID] 300040 Cornelia de Lange syndrome 2, 300590 (3) XLD;Developmental and epileptic encephalopathy 85, with or without midline brain defects, 301044 (3) XLD XLD yes 0 1.0000e+00 9.9999e-01 full=5 -11_66287089_66288847_DEL_1 11 66287089 66288847 -1758 DEL BBS1 internal frameshift Pathogenic NA full q13.2 BBS1;ZDHHC24 2 BANF1 (morbid/RE=EA_enhancer);C11orf80 (morbid/RE=EA_enhancer);CATSPER1 (morbid/RE=EA_enhancer);CTSF (morbid/RE=EA_enhancer);FIBP (morbid/RE=EA_enhancer);KLC2 (morbid/RE=EA_enhancer);PACS1 (morbid/RE=EA_enhancer);PC (morbid/RE=EA_enhancer);SF3B2 (morbid/RE=EA_enhancer);SPTBN2 (morbid/RE=EA_enhancer) dbVar:nssv15171978;dbVar:nssv15158476;dbVar:nssv15150306;nssv15150623;dbVar:nssv15150659;dbVar:nssv15605814;dbVar:nssv15146474;dbVar:nssv17973682 11:70865-134938470;11:198511-134934063;11:230617-134938470;11:64501920-67129258;11:65138977-67574402;11:65960974-67658241;11:66281868-66288857 0.00;0.00;0.00;0.07;0.07;0.10;25.16 Bardet-Biedl syndrome 1, 209900 (3) AR,Digenic recessive dbVar:nssv16867095;dbVar:nssv15148225;dbVar:nssv15129970;morbid:BBS1;dbVar:nssv16214536;dbVar:nssv17171795;dbVar:nssv17971967;dbVar:nssv16212285;dbVar:nssv17974991;dbVar:nssv17172605;dbVar:nssv16212781;dbVar:nssv15128612;dbVar:nssv17172606 11:11835570-118373112;11:65508903-67473140;11:66274841-66292574;11:66278106-66301069;11:66278112-66291373;11:66278112-66299528;11:66278122-66291363;11:66278122-66291682;11:66283002-66287229;11:66283155-66287229;11:66287079-66288857;11:66288384-66293649;11:66288722-66293683 0.00;0.09;9.92;7.66;13.26;8.21;13.28;12.97;3.33;3.46;98.88;8.81;2.54 6 Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_1 0.565 0.545 67.28 -0.648300458519823 0.663432885116562 0.155145712015149 0.635599914039232 1.04727080312339 209901 yes 5 4.2080e-04 6.1403e-03 0.9 1A (cf Gene_count, RE_gene, +0.00);2E-1 (BBS1, +0.90);3A (2 genes, +0.00);5F (+0.00) 4 -11_66287089_66288847_DEL_1 11 66287089 66288847 -1758 DEL BBS1 internal frameshift Pathogenic NA split q13.2 BBS1 NM_024649 66278105 66301069 1759 238 13 yes 17 exon8-intron9 CDS 0 5' 66287088 66288847 6 Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_1 40.7 -0.648300458519823 0.663432885116562 0.155145712015149 0.0819191978639822 0.0377121632347663 Bardet-Biedl syndrome;Bardet-Biedl syndrome 1 AR Definitive;Strong;Supportive 20301537[PMID] 209901 Bardet-Biedl syndrome 1, 209900 (3) AR,Digenic recessive AR,Digenic recessive yes 5 3.4063e-12 1.7787e-07 full=4 -11_66287089_66288847_DEL_1 11 66287089 66288847 -1758 DEL BBS1 internal frameshift Pathogenic NA split q13.2 ZDHHC24 NM_001348571 66288095 66313519 752 0 0 no 5 exon5-txEnd 3'UTR 90 3' 66288095 66288847 2 Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_1 67.28 -1.23986898178133 0.616417349113344 -0.188374414893838 0.635599914039232 1.04727080312339 7 4.2080e-04 6.1403e-03 full=4 -7_33397468_33397607_DEL_1 7 33397468 33397607 -139 DEL BBS9 inframe Pathogenic NA full p14.3 BBS9 1 dbVar:nssv15777247;dbVar:nssv15168013;dbVar:nssv15161666;nssv15161679;dbVar:nssv15168014;dbVar:nssv15161745;dbVar:nssv15161726;dbVar:nssv17970196;dbVar:nssv15161869;dbVar:nssv15161632;dbVar:nssv17970205;dbVar:nssv15133397;dbVar:nssv15154527;dbVar:nssv15146465 7:10366-159119707;7:10705-159122532;7:43362-159119707;7:44936-159126310;7:54186-37129317;7:54186-41915483;7:10745751-35305167;7:11048841-52863626;7:11562625-36395416;7:27507833-39072473;7:30460550-34600277;7:30463887-43470805;7:33367925-61831899 0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00 Bardet-Biedl syndrome 9, 615986 (3) AR dbVar:nssv15161318;dbVar:nssv15138559;dbVar:nssv15147510;dbVar:nssv15148432;morbid:BBS9;dbVar:nssv17971381 7:54186-159075079;7:30977986-33440608;7:32718004-41084581;7:32911004-44576005;7:33169176-33675379;7:33296829-33427776 0.00;0.01;0.00;0.00;0.03;0.11 1 Bardet-Biedl_syndrome 0.325 0.370 17.13 -2.43637392050626 -2.53125239294469 -2.47162789907313 -0.989035894351638 -1.15018109964609 607968 yes 4 4.2117e-17 6.3752e-10 0.9 1A (cf Gene_count, RE_gene, +0.00);2E-1 (BBS9, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -7_33397468_33397607_DEL_1 7 33397468 33397607 -139 DEL BBS9 inframe Pathogenic NA split p14.3 BBS9 NM_001348036 33168896 33645680 140 140 5 yes 23 exon16-intron16 CDS 0 5' 33397467 33397607 1 Bardet-Biedl_syndrome 17.13 -2.43637392050626 -2.53125239294469 -2.47162789907313 -0.989035894351638 -1.15018109964609 Bardet-Biedl syndrome;Bardet-Biedl syndrome 9 AR Definitive;Strong;Supportive 20301537[PMID] 607968 Bardet-Biedl syndrome 9, 615986 (3) AR AR yes 4 4.2117e-17 6.3752e-10 full=4 -12_63935482_64130626_DUP_1 12 63935482 64130626 195144 DUP DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA full q14.2 DPY19L2 1 RXYLT1 (morbid/RE=GH_Enhancer);TBK1 (morbid/RE=EA_enhancer) Spermatogenic failure 9, 613958 (3) AR dbVar:nssv15119764;dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63952694-64062354;12:63989747-63989817 dbVar:nssv15161620;dbVar:nssv15161414;nssv15161422;dbVar:nssv15171852;dbVar:nssv15161798;dbVar:nssv15171855 12:2-133851895;12:173788-133777902;12:191620-133777645;12:282466-133773393;12:621221-133779118 0.15;0.15;0.15;0.15;0.15 dbVar:nssv15136921 12:61300933-66961857 3.45 1 Spermatogenic_failure_9 12:64020291-64020367 DDD:38896;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 esv3629757;12:63949898-63949980 gnomAD-SV_v2.1_DUP_12_34998;12:64069043-64136500 dgv280e214;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888 12:63949898-63949980 gnomAD-SV_v2.1_DUP_12_34998;12:64069043-64136500 dgv280e214;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888;12:64020291-64020367 DDD:38896;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 esv3629757 12:63950173-63950264 CMRI:1_pbsv.DEL.823;12:63946730-63946956 esv2662353;12:63946730-63946956 CMRI:1_pbsv.DEL.822_duplicate1;12:63950173-63950264 CMRI:1_pbsv.DEL.823;12:63946730-63946956 esv2662353;12:63946730-63946956 CMRI:1_pbsv.DEL.822_duplicate1 12:63950172-63950241 gnomAD-SV_v2.1_DEL_12_129266;12:64020291-64020367 DDD:38896;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265;12:63950172-63950241 gnomAD-SV_v2.1_DEL_12_129266;12:64020291-64020367 DDD:38896;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265 1054499;1054500;1087307;119292;1194770;1209828;1267803;1328263;1491350;1619448;174035;1760195;1881832;1883558;2089432;2353750;2419380;2692928;2792491;2814116;2850280;287527;2965163;31158;350981;693309;981327 gain;loss 0.530 0.430 12:63935369-63935656 AluSq2 12:64130409-64130696 AluSq2 12:63923419-63951619 12:64119249-64146247 81.13 1.02618176351368 1.66555804568279 613893 yes 4 1.0936e-13 7.0294e-05 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2G (cf po_B_gain_someG_source, +0.00)2H-2 (DPY19L2, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 -12_63935482_64130626_DUP_1 12 63935482 64130626 195144 DUP DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA split q14.2 DPY19L2 NM_173812 63952692 64062273 109581 2277 100 no 22 txStart-txEnd 5'UTR-3'UTR 63952692 64062273 Spermatogenic failure 9, 613958 (3) AR dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63989747-63989817 1 Spermatogenic_failure_9 1000g;DDD:38888;esv3629757;gnomAD-SV_v2.1_DUP_12_34997 12:63936386-64131550;12:63939159-64117235;12:63939159-64117235;12:63940549-64135811 0.0257 1054499;1054500;1267803;1760195 gain;loss 81.13 1.02618176351368 1.66555804568279 male infertility due to globozoospermia;spermatogenic failure 9 AR Strong;Supportive 21397063;21397063[PMID]_22571172[PMID];21397064 613893 Spermatogenic failure 9, 613958 (3) AR AR yes 4 1.0936e-13 7.0294e-05 full=3 -16_1565630_1571297_DUP_1 16 1565630 1571297 5667 DUP IFT140 tandem duplication Pathogenic NA full p13.3 IFT140 1 dbVar:nssv16208781 16:1568218-1570809 Cranioectodermal_dysplasia|Saldino-Mainzer_syndrome|Joubert_syndrome_with_Jeune_asphyxiating_thoracic_dystrophy dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15147067;dbVar:nssv15148669;dbVar:nssv15147068;dbVar:nssv17649874;dbVar:nssv15152396;dbVar:nssv15150758;dbVar:nssv15149904;dbVar:nssv15154767;dbVar:nssv16254459;dbVar:nssv15149503;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv15147425;dbVar:nssv15147959;dbVar:nssv15147069;dbVar:nssv15148094;dbVar:nssv15147790;dbVar:nssv8639650;dbVar:nssv15606077;dbVar:nssv15146792;dbVar:nssv15147071;dbVar:nssv15145754;dbVar:nssv15155466;dbVar:nssv17955877;CLN:513805 16:61452-90294632;16:69194-90274381;16:73142-11390552;16:78802-9169448;16:79942-2610461;16:84486-5251013;16:85881-11209288;16:85881-19806921;16:85881-22442007;16:85881-3216551;16:85881-5249457;16:85881-9883129;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:93733-13420663;16:96767-11619372;16:96767-3264623;16:96767-4297186;16:97134-5122974;16:102840-28327676;16:109979-4316797;16:716663-15836961;16:1271652-2283774;16:1328823-1969149;16:1505185-4415346;16:1561202-1573469;16:1565629-1571298 0.01;0.01;0.05;0.06;0.22;0.11;0.05;0.03;0.03;0.18;0.11;0.06;0.01;0.01;0.01;0.04;0.05;0.18;0.13;0.11;0.02;0.13;0.04;0.56;0.89;0.19;46.20;99.96 Retinitis pigmentosa 80, 617781 (3) AR;Short-rib thoracic dysplasia 9 with or without polydactyly, 266920 (3) AR dbVar:nssv15173022;dbVar:nssv15145815;dbVar:nssv15147164;dbVar:nssv15155465;dbVar:nssv15776300;dbVar:nssv15146945;dbVar:nssv15148829;dbVar:nssv15148018;dbVar:nssv15145816;dbVar:nssv15771714;dbVar:nssv16214818;dbVar:nssv16214651;morbid:IFT140 16:61452-1593645;16:73142-1762524;16:73142-1823350;16:85881-1875694;16:85881-2053328;16:88166-1715454;16:96723-1917328;16:96767-1594015;16:96767-2047583;16:624056-2115656;16:624056-2148005;16:1203719-2185710;16:1560428-1662073 0.37;0.34;0.32;0.32;0.29;0.35;0.31;0.38;0.29;0.38;0.37;0.58;5.58 10 Jeune_thoracic_dystrophy;Retinal_dystrophy;Retinitis_pigmentosa;Saldino-Mainzer_syndrome 0.520 0.500 16:1565418-1565697;16:1565698-1565893 AluJr;L1MEf 16:1571134-1571365 AluJb 69.24 -1.52736818830718 -0.448946429663129 -0.844654865976432 -0.922111894578121 -1.23259677674915 614620 yes 4 9.9140e-24 9.1377e-18 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2I-3 (IFT140, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 -16_1565630_1571297_DUP_1 16 1565630 1571297 5667 DUP IFT140 tandem duplication Pathogenic NA split p13.3 IFT140 NM_014714 1560427 1662073 5668 729 16 no 31 intron26-intron30 CDS 488 3' 1565629 1571297 dbVar:nssv16208781 16:1568218-1570809 10 Jeune_thoracic_dystrophy;Retinal_dystrophy;Retinitis_pigmentosa;Saldino-Mainzer_syndrome 30 69.24 -1.52736818830718 -0.448946429663129 -0.844654865976432 -0.922111894578121 -1.23259677674915 Jeune syndrome;Leber congenital amaurosis;retinitis pigmentosa;short-rib thoracic dysplasia 9 with or without polydactyly AD;AR Definitive;Supportive 22503633;22503633[PMID];22503633[PMID]_23418020[PMID]_24009529[PMID];26216056[PMID] 614620 Retinitis pigmentosa 80, 617781 (3) AR;Short-rib thoracic dysplasia 9 with or without polydactyly, 266920 (3) AR AR yes 4 9.9140e-24 9.1377e-18 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA full p11.2-p11.1 CCNYL3;ENPP7P13;HERC2P4;LINC01566;LOC102723655;LOC102723713;LOC102723753;LOC105369266;LOC112268173;LOC390705;MIR9901;SLC6A10P;TP53TG3;TP53TG3B;TP53TG3C;TP53TG3D;TP53TG3E;TP53TG3F;UBE2MP1 19 ARMC5 (morbid/RE=GH_Promoter) dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv16216874;dbVar:nssv15126545;dbVar:nssv15133058;dbVar:nssv15126469;dbVar:nssv15150356 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:5805002-34230001;16:24381954-33923059;16:30703234-35147508;16:31986099-90294753;16:34197493-64509054 3.04;3.05;3.05;3.05;3.05;8.00;20.63;61.82;4.66;1.67 dbVar:nssv15141243 16:28826163-34375007 43.61 16:31986000-31992300 gnomAD-SV_v2.1_DUP_16_42015;16:32006000-32011000 gnomAD-SV_v2.1_DUP_16_42019;16:32193431-32193767 DDD:47069;16:32232000-32237100 gnomAD-SV_v2.1_DUP_16_42027;16:32439203-32439203 1000g;16:32486529-32486871 DDD:47082;16:32740800-32750700 gnomAD-SV_v2.1_DUP_16_42037;16:32900256-32908555 nsv514802;16:33237167-33240395 CMRI:0_pbsv.SPLIT.DUP.569;16:33237168-33239696 CMRI:36_pbsv.SPLIT.DUP.817;16:33237169-33241215 CMRI:25_pbsv.SPLIT.DUP.690;16:33406670-33406761 CMRI:3_pbsv.INS.DUP.833_duplicate1;16:33509676-33509763 gnomAD-SV_v2.1_DUP_16_42048;16:33673500-33681600 gnomAD-SV_v2.1_DUP_16_42055;16:33800500-33815000 gnomAD-SV_v2.1_DUP_16_42059;16:33920792-33920792 1000g;16:33961733-33961778 DDD:47155;16:31989000-32033000 gnomAD-SV_v2.1_DUP_16_42016;16:32020000-32096000 gnomAD-SV_v2.1_DUP_16_42022;16:32128500-32133600 gnomAD-SV_v2.1_DUP_16_42025;16:32328772-32370968 1000g... 16:31985111-31985155 DDD:47053;16:32001000-32010000 gnomAD-SV_v2.1_DUP_16_42018;16:32020000-32026200 gnomAD-SV_v2.1_DUP_16_42021;16:32202950-32209100 gnomAD-SV_v2.1_DUP_16_42026;16:32398388-32398388 1000g;16:32473116-32486576 DDD:47080;16:32593538-32593538 1000g;16:32772000-32777000 gnomAD-SV_v2.1_DUP_16_42039;16:33231300-33237300 gnomAD-SV_v2.1_DUP_16_42041;16:33237168-33239048 CMRI:24_pbsv.SPLIT.DUP.761;16:33237168-33240638 CMRI:2_pbsv.SPLIT.DUP.788;16:33237859-33241258 CMRI:6_pbsv.SPLIT.DUP.921;16:33467710-33467710 1000g;16:33616546-33616626 gnomAD-SV_v2.1_DUP_16_42050;16:33794000-33799000 gnomAD-SV_v2.1_DUP_16_42058;16:33888900-33894600 gnomAD-SV_v2.1_DUP_16_42065;16:33932000-33938000 gnomAD-SV_v2.1_DUP_16_42069;16:31988999-32093700 gnomAD-SV_v2.1_DUP_16_42017;16:32020000-32096000 TS40:ISCA-46491;16:32127000-32132000 gnomAD-SV_v2.1_DUP_16_42024;16:32328772-32370968 1000g... 16:32036000-32041500 gnomAD-SV_v2.1_DEL_16_153838;16:32227774-32227839 CMRI:11_pbsv.DEL.1073_duplicate3;16:32393247-32393542 gnomAD-SV_v2.1_DEL_16_153847;16:32454301-32454474 CMRI:11_pbsv.DEL.1079_duplicate2;16:32513047-32514413 CMRI:14_pbsv.DEL.714_duplicate7;16:32523772-32525827 CMRI:77_pbsv.DEL.783_duplicate11;16:32588181-32590788 esv3638433;16:32598582-32602963 esv3638436;16:32600306-32601869 esv3638437;16:32823142-32823276 CMRI:32_pbsv.DEL.766_duplicate11;16:32913496-32913558 CMRI:42_pbsv.DEL.503_duplicate7;16:33053570-33055362 CMRI:32_pbsv.DEL.767_duplicate8;16:33070335-33070437 CMRI:0_pbsv.DEL.568_duplicate8;16:33238346-33238403 CMRI:7_pbsv.DEL.745_duplicate8;16:33405371-33405435 CMRI:6_pbsv.DEL.927_duplicate10;16:33433594-33433957 gnomAD-SV_v2.1_DEL_16_153879;16:33462282-33462339 gnomAD-SV_v2.1_DEL_16_153880;16:33589117-33599697 1000g;16:33604896-33605259 gnomAD-SV_v2.1_DEL_16_153891;16:33604997-33605259 esv2676710;16:33611945-33612241 1000g... 16:31971930-31972305 CMRI:33_pbsv.DEL.557_duplicate8;16:32107654-32107713 CMRI:2_pbsv.DEL.780_duplicate7;16:32294372-32294452 gnomAD-SV_v2.1_DEL_16_153842;16:32419951-32420000 CMRI:4_pbsv.DEL.824_duplicate7;16:32486808-32486871 DDD:47084;16:32520009-32520694 CMRI:59_pbsv.DEL.501_duplicate7;16:32588181-32590788 1000g;16:32598582-32602963 1000g;16:32600306-32601869 1000g;16:32658500-32665500 gnomAD-SV_v2.1_DEL_16_153862;16:32854307-32854394 gnomAD-SV_v2.1_DEL_16_153866;16:33025349-33025404 CMRI:18_pbsv.DEL.717_duplicate7;16:33070282-33070437 CMRI:0_pbsv.DEL.567_duplicate7;16:33237308-33237424 CMRI:16_pbsv.DEL.487_duplicate8;16:33240635-33240708 CMRI:150_pbsv.DEL.581_duplicate6;16:33417667-33419043 CMRI:88_pbsv.DEL.792_duplicate7;16:33429085-33429134 CMRI:3_pbsv.DEL.834_duplicate5;16:33559201-33559298 gnomAD-SV_v2.1_DEL_16_153886;16:33589117-33599697 esv3638477;16:33604997-33605259 1000g;16:33611849-33612241 gnomAD-SV_v2.1_DEL_16_153892... 1007437;1007438;1012614;1014522;1014523;1015016;1015018;1015393;1015396;1016276;1016277;1016630;1016631;1016992;1017261;1017263;1017677;1017918;1018209;1018210;1018211;1018436;1018437;1018438;1018684;1018685;1018686;1018839;1018840;1019049;1019196;1019197;1019198;1019440;1019700;1019701;1019937;1020689;1020690;1020691;1020693;1020694;1020963;1021227;1021228;1021229;1021230;1021529;1021530;1022156;1022158;... gain;loss 0.225 0.335 16:31948879-31955047;16:31955090-31955836 L1PA3;L1M4c 94.39 1.56757328357025 2.11426077975333 9 7.5995e-03 6.4106e-01 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2G (cf po_B_gain_someG_source, +0.00)3A (19 genes, +0.00);5F (+0.00) 3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 CCNYL3 NR_158158 34264719 34294699 29980 0 0 no 11 txStart-txEnd UTR 34264719 34294699 TS40:ISCA-37481;dgv51e203;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859 0.0600 HI40:ISCA-37481 16:34202089-35147508 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 ENPP7P13 NR_130771 33571843 33586742 14899 0 0 no 3 txStart-txEnd UTR 33571843 33586742 DDD:47058;DDD:47062;DDD:47114;DDD:47116;DDD:47126;DDD:47131;DDD:47136;dgv50e203;dgv821e212;nsv514803 16:33560604-33662009;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324;16:33230271-33739925;16:33270420-33827235;16:33302092-33630727;16:33473790-33628580;16:33526621-33659628 0.5150 DDD:47058;DDD:47062;DDD:47114;DDD:47126;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33230271-33739925;16:33473790-33628580 0.1243 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 HERC2P4 NR_109773 32181363 32199434 18071 0 0 no 14 txStart-txEnd UTR 32181363 32199434 DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:32052946-32496748;16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1692 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2-p11.1 LINC01566 NR_027080 34597786 34626084 28298 0 0 no 7 txStart-txEnd UTR 34597786 34626084 1000g;DDD:47173;DDD:47179;DDD:47183;TS40:ISCA-37481;dgv117e55;dgv2962n100;dgv51e203;dgv824e212;esv2421698;esv3638500;gnomAD-SV_v2.1_DUP_16_42078;gnomAD-SV_v2.1_DUP_16_42081;nsv514804;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531;16:34441796-34784591;16:34445084-34774280;16:34456525-34736855;16:34457086-34712399;16:34457086-34712399;16:34465000-34757000;16:34470705-34757071;16:34471852-34731191;16:34476781-34747070;16:34567146-34656231;16:34572795-34661165 0.1875 HI40:ISCA-37481 16:34202089-35147508 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC102723655 NM_001368237 32684839 32687448 2609 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684839 32687448 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC102723713 NM_001368231 32264643 32267243 2600 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32264643 32267243 DDD:47058;DDD:47062;DDD:47063;dgv50e203;esv2421440 16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203;esv2421440 16:32052946-32496748;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC102723753 NR_135178 32163432 32199434 36002 0 0 no 25 txStart-txEnd UTR 32163432 32199434 DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:32052946-32496748;16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1692 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC105369266 NR_158162 33215160 33231582 16422 0 0 no 5 txStart-txEnd UTR 33215160 33231582 DDD:47058;DDD:47062;DDD:47113;dgv50e203;dgv821e212 16:33204449-33378738;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.0700 DDD:47058;DDD:47062;DDD:47113;dgv50e203 16:33204449-33378738;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.0715 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC112268173 NR_157261 34430129 34431919 1790 0 0 no 1 txStart-txEnd UTR 34430129 34431919 TS40:ISCA-37481;dgv117e55;dgv51e203;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531 0.0900 HI40:ISCA-37481 16:34202089-35147508 CMRI:6_pbsv.INV.947 16:34396540-34464124 0.0319 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC390705 NR_033866 32300867 32301302 435 0 0 no 1 txStart-txEnd UTR 32300867 32301302 DDD:47058;DDD:47062;DDD:47063;dgv50e203;esv2421440 16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;DDD:47074;dgv50e203;esv2421440 16:32052946-32496748;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 MIR9901 NR_162093 33966044 33966140 96 0 0 no 1 txStart-txEnd UTR 33966044 33966140 dgv50e203 16:31749454-34012168 0.0700 dgv50e203 16:31749454-34012168 0.0500 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 SLC6A10P NR_003083 32888796 32896463 7667 0 0 no 9 txStart-txEnd UTR 32888796 32896463 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212 16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1314 DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1692 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3 NM_016212 32684848 32687450 2602 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684848 32687450 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 94.39 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3B NM_001099687 32684848 32687450 2602 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684848 32687450 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 92.24 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3C NM_001205259 32685408 32687448 2040 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32685408 32687448 DDD:47058;DDD:47062;DDD:47063;DDD:47098;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32684868-32688916;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;DDD:47098;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32684868-32688916;16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 91.96 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3D NM_001243722 32264644 32267249 2605 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32264644 32267249 DDD:47058;DDD:47062;DDD:47063;dgv50e203;esv2421440 16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203;esv2421440 16:32052946-32496748;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 92.49 1.56757328357025 2.11426077975333 9 7.5995e-03 6.4106e-01 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3E NM_001330061 32684844 32687431 2587 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684844 32687431 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3F NM_001330066 32684848 32687430 2582 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684848 32687430 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=3 -16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 UBE2MP1 NR_002837 34403801 34404762 961 0 0 no 1 txStart-txEnd UTR 34403801 34404762 TS40:ISCA-37481;dgv51e203;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859 0.0600 HI40:ISCA-37481 16:34202089-35147508 CMRI:6_pbsv.INV.947 16:34396540-34464124 0.0319 full=3 -16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA full p11.2 CCNYL3;ENPP7P13;MIR9901 3 dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv16216874;dbVar:nssv15126545;dbVar:nssv15133058;dbVar:nssv15126469;dbVar:nssv15150356 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:5805002-34230001;16:24381954-33923059;16:30703234-35147508;16:31986099-90294753;16:34197493-64509054 1.01;1.01;1.02;1.02;1.01;3.02;5.78;20.57;1.57;0.29 dbVar:nssv15141243 16:28826163-34375007 16.48 16:33467710-33467710 1000g;16:33616546-33616626 gnomAD-SV_v2.1_DUP_16_42050;16:33794000-33799000 gnomAD-SV_v2.1_DUP_16_42058;16:33888900-33894600 gnomAD-SV_v2.1_DUP_16_42065;16:33932000-33938000 gnomAD-SV_v2.1_DUP_16_42069;16:33446164-33480261 1000g;16:33446164-33480261 dgv510e214;16:33470756-33495606 1000g;16:33470756-33495606 dgv511e214;16:33484522-33543753 1000g;16:33560604-33662009 DDD:47136;16:33588533-33626594 1000g;16:33588533-33626594 dgv514e214;16:33777225-33787700 gnomAD-SV_v2.1_DUP_16_42057;16:33843000-33864000 gnomAD-SV_v2.1_DUP_16_42063;16:33879457-33912806 esv3892831;16:33926700-33939600 gnomAD-SV_v2.1_DUP_16_42068;16:34174075-34180000 gnomAD-SV_v2.1_DUP_16_42071;16:33376004-33548487 DDD:47124;16:34197352-35283226 dgv51e203;16:34259806-34805859 nsv516385... 16:33406670-33406761 CMRI:3_pbsv.INS.DUP.833_duplicate1;16:33509676-33509763 gnomAD-SV_v2.1_DUP_16_42048;16:33673500-33681600 gnomAD-SV_v2.1_DUP_16_42055;16:33800500-33815000 gnomAD-SV_v2.1_DUP_16_42059;16:33920792-33920792 1000g;16:33961733-33961778 DDD:47155;16:33446164-33480261 1000g;16:33464249-33499453 DDD:47125;16:33470756-33495606 1000g;16:33484522-33543753 1000g;16:33484522-33543753 dgv512e214;16:33582387-33629628 DDD:47138;16:33588533-33626594 1000g;16:33669000-33681000 gnomAD-SV_v2.1_DUP_16_42054;16:33783303-33785890 DDD:47148;16:33870630-33923125 esv3892830;16:33921000-33939600 gnomAD-SV_v2.1_DUP_16_42066;16:33961808-33964212 DDD:47156;16:33204449-33378738 DDD:47113;16:33983829-34200953 DDD:47158;16:34202089-35147508 TS40:ISCA-37481... 16:33417667-33419043 CMRI:88_pbsv.DEL.792_duplicate7;16:33429085-33429134 CMRI:3_pbsv.DEL.834_duplicate5;16:33559201-33559298 gnomAD-SV_v2.1_DEL_16_153886;16:33589117-33599697 esv3638477;16:33604997-33605259 1000g;16:33611849-33612241 gnomAD-SV_v2.1_DEL_16_153892;16:33615207-33615483 gnomAD-SV_v2.1_DEL_16_153893;16:33653000-33659000 gnomAD-SV_v2.1_DEL_16_153896;16:33721800-33726900 gnomAD-SV_v2.1_DEL_16_153898;16:33794000-33799500 gnomAD-SV_v2.1_DEL_16_153904;16:33820899-33820950 CMRI:3_pbsv.DEL.838_duplicate8;16:33864546-33864759 CMRI:0_pbsv.DEL.573_duplicate8;16:33866202-33866353 CMRI:7_pbsv.DEL.754_duplicate7;16:33866739-33867011 CMRI:1_pbsv.DEL.535_duplicate11;16:33866750-33866973 CMRI:7_pbsv.DEL.755_duplicate10;16:33867833-33867999 CMRI:56_pbsv.DEL.672_duplicate7;16:33894121-33894172 1000g;16:33953925-33953976 CMRI:11_pbsv.DEL.1122_duplicate4;16:33981666-33983060 CMRI:79_pbsv.DEL.537_duplicate10;16:33988626-33990336 CMRI:7_pbsv.DEL.757_duplicate7;16:33989505-33991216 CMRI:11_pbsv.DEL.1125_duplicate6... 16:33405371-33405435 CMRI:6_pbsv.DEL.927_duplicate10;16:33433594-33433957 gnomAD-SV_v2.1_DEL_16_153879;16:33462282-33462339 gnomAD-SV_v2.1_DEL_16_153880;16:33589117-33599697 1000g;16:33604896-33605259 gnomAD-SV_v2.1_DEL_16_153891;16:33604997-33605259 esv2676710;16:33611945-33612241 1000g;16:33642050-33647850 gnomAD-SV_v2.1_DEL_16_153895;16:33660075-33668925 gnomAD-SV_v2.1_DEL_16_153897;16:33754067-33754234 CMRI:6_pbsv.DEL.934_duplicate9;16:33822900-33828600 gnomAD-SV_v2.1_DEL_16_153908;16:33864546-33864759 1000g;16:33866201-33866482 CMRI:141_pbsv.DEL.578_duplicate7;16:33866359-33866573 CMRI:0_pbsv.DEL.574_duplicate8;16:33866743-33867000 CMRI:45_pbsv.DEL.532_duplicate7;16:33866756-33866996 CMRI:1_pbsv.DEL.536_duplicate11;16:33868877-33869209 CMRI:2_pbsv.DEL.801_duplicate5;16:33905093-33906459 CMRI:37_pbsv.DEL.688_duplicate7;16:33993018-33993970 esv2660547;16:33988384-33990094 CMRI:0_pbsv.DEL.575_duplicate6;16:33989200-33990911 CMRI:11_pbsv.DEL.1124_duplicate1... 1015018;1015396;1016631;1017677;1017918;1018211;1018438;1018686;1019198;1020693;1023638;1024075;1024313;1024700;1024918;1026222;1026223;1026632;1026633;1026898;1027138;1179324;1685031;1699997;2344662;2397905;2426917;2490784;416079;451235;491448;601857;602760;603373;604311;605488;608013;608956;609267;609572;646530;647522;647806;650742;650931;651558;653203;653368;653706;653934;655251;... gain;loss 0.430 0.365 16:33371221-33371434 AluSz6 16:33241272-33372204;16:33325624-33372204;16:33330495-33372204;16:33330495-33372204;16:33342946-33372204;16:33353245-33373923;16:33355202-33372204;16:33363548-33517471 16:32923001-33427100 High Signal Region 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2G (cf po_B_gain_someG_source, +0.00)2L (CCNYL3, +0.00);3A (3 genes, +0.00);5F (+0.00) 3 -16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA split p11.2 CCNYL3 NR_158158 34264719 34294699 21129 0 0 no 11 txStart-intron9 UTR 82 5' 34264719 34285848 TS40:ISCA-37481;dgv51e203;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859 0.0600 HI40:ISCA-37481 16:34202089-35147508 full=3 -16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA split p11.2 ENPP7P13 NR_130771 33571843 33586742 14899 0 0 no 3 txStart-txEnd UTR 33571843 33586742 DDD:47058;DDD:47062;DDD:47114;DDD:47116;DDD:47126;DDD:47131;DDD:47136;dgv50e203;dgv821e212;nsv514803 16:33560604-33662009;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324;16:33230271-33739925;16:33270420-33827235;16:33302092-33630727;16:33473790-33628580;16:33526621-33659628 0.5150 DDD:47058;DDD:47062;DDD:47114;DDD:47126;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33230271-33739925;16:33473790-33628580 0.1243 full=3 -16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA split p11.2 MIR9901 NR_162093 33966044 33966140 96 0 0 no 1 txStart-txEnd UTR 33966044 33966140 dgv50e203 16:31749454-34012168 0.0700 dgv50e203 16:31749454-34012168 0.0500 full=3 -5_723195_777000_DUP_1 5 723195 777000 53805 DUP Benign NA full p15.33 ZDHHC11B 1 SDHA (morbid/RE=EA_enhancer);SLC9A3 (morbid/RE=GH_Enhancer);TRIP13 (morbid/RE=EA_enhancer) dbVar:nssv15164761;dbVar:nssv15125831;dbVar:nssv15146713;dbVar:nssv15139036;dbVar:nssv15136993;dbVar:nssv15145871;dbVar:nssv15147378;dbVar:nssv15147960;dbVar:nssv15146962;dbVar:nssv15147414;dbVar:nssv15164765;dbVar:nssv15164764;dbVar:nssv15149091;dbVar:nssv15147291;dbVar:nssv15146993;dbVar:nssv15146992;dbVar:nssv15150844;dbVar:nssv15153658;dbVar:nssv15151111;nssv15151221 5:13649-180905029;5:22150-10308848;5:22150-15851485;5:22150-1659250;5:22150-2324057;5:22150-23607162;5:22150-28075213;5:22150-33418294;5:22150-34041255;5:22150-73708550;5:25329-180693344;5:25329-18698028;5:25329-19661628;5:50094-46115086;5:54955-35680947;5:54955-45649963;5:113577-20240392;5:113577-35739404;5:113578-180719789 0.03;0.52;0.34;3.29;2.34;0.23;0.19;0.16;0.16;0.07;0.03;0.29;0.27;0.12;0.15;0.12;0.27;0.15;0.03 5p15 terminal (Cri du chat syndrome) region dbVar:nssv17649947;dbVar:nssv15147173;dbVar:nssv15145875;dbVar:nssv15147440;dbVar:nssv15146459;dbVar:nssv15146622;dbVar:nssv15147702;dbVar:nssv15136268;dbVar:nssv15146696;dbVar:nssv15145969;dbVar:nssv15151220;dbVar:nssv15132269;dbVar:nssv15148862;dbVar:nssv15148231;dbVar:nssv15147402;dbVar:nssv15146458;dbVar:nssv15149597;dbVar:nssv15147956;dbVar:nssv15148968;dbVar:nssv15148844;dbVar:nssv15146717;dbVar:nssv15148985;dbVar:nssv15148016;dbVar:nssv15148112;dbVar:nssv15145972;dbVar:nssv16866488;dbVar:nssv15140376;dbVar:nssv15148058;dbVar:nssv15148554;dbVar:nssv15132604;dbVar:nssv15134412;dbVar:nssv15147416;dbVar:nssv15140515;dbVar:nssv15135741;dbVar:nssv15141721;dbVar:nssv15138139;dbVar:nssv15139127;dbVar:nssv15139876;dbVar:nssv15134733;dbVar:nssv15142657;dbVar:nssv15141520;dbVar:nssv15147171;dbVar:nssv15150118;dbVar:nssv15146522;dbVar:nssv15164763;dbVar:nssv15150859;dbVar:nssv15166282;dbVar:nssv15132966;dbVar:nssv15132967;HI3:ISCA-37390;dbVar:nssv15146165;nssv15146815;dbVar:nssv15148064;dbVar:nssv15132680;dbVar:nssv15223218;dbVar:nssv15134417;dbVar:nssv16216549;dbVar:nssv15149121;dbVar:nssv15150161;dbVar:nssv15137858;dbVar:nssv15150229;dbVar:nssv15149886;dbVar:nssv16208009;dbVar:nssv15148942;dbVar:nssv16208008;dbVar:nssv15149911;dbVar:nssv15151402;dbVar:nssv15153655;dbVar:nssv15152885;dbVar:nssv15151403;dbVar:nssv15149508;dbVar:nssv16208007;dbVar:nssv15151241;dbVar:nssv15150601;dbVar:nssv15150625;dbVar:nssv15145995;dbVar:nssv15151861;dbVar:nssv16255066;dbVar:nssv16208006;dbVar:nssv16208011;dbVar:nssv15142295;dbVar:nssv16208010;dbVar:nssv15153656;dbVar:nssv15152886;dbVar:nssv15137538;dbVar:nssv15153657;dbVar:nssv15146000;dbVar:nssv17956677;dbVar:nssv15606071;dbVar:nssv15606072;dbVar:nssv16213555;dbVar:nssv16213990;dbVar:nssv17970513;dbVar:nssv17971003 5:13201-4012072;5:22150-10044199;5:22150-11429370;5:22150-11530503;5:22150-12004203;5:22150-12820111;5:22150-13362684;5:22150-1429714;5:22150-16584684;5:22150-16930125;5:22150-17788806;5:22150-1826370;5:22150-21217229;5:22150-21726469;5:22150-22775404;5:22150-23132155;5:22150-24835567;5:22150-25699714;5:22150-26594000;5:22150-27188057;5:22150-27485726;5:22150-27611270;5:22150-27788723;5:22150-28429348;5:22150-28589299;5:22150-29048823;5:22150-2965987;5:22150-32248116;5:22150-34041196;5:22150-3404358;5:22150-3557056;5:22150-35831640;5:22150-4163847;5:22150-4260264;5:22150-4641409;5:22150-4833739;5:22150-5060009;5:22150-5102699;5:22150-6060215;5:22150-6112711;5:22150-6500967;5:22150-7213388;5:22150-9958240;5:22420-19281001;5:25329-18662625;5:25329-30672798;5:25329-31343671;5:37693-2747022;5:37693-2913319;5:37694-11347262;5:50094-15678560;5:50094-30112642;5:50094-4014761;5:52187-4163906;5:54955-5603514;5:71905-22078969;5:79147-15509107;5:79147-22152284;5:95244-5834664;5:113577-10163809;5:113577-10729838;5:113577-11767720;5:113577-14684471;5:113577-14738180;5:113577-15291661;5:113577-15822225;5:113577-1708530;5:113577-1816055;5:113577-19167699;5:113577-23047959;5:113577-23364376;5:113577-25091472;5:113577-26234903;5:113577-26948599;5:113577-33998394;5:113577-4175855;5:113577-4305172;5:113577-4325585;5:113577-5194484;5:113577-5380741;5:113577-5657333;5:113577-5884399;5:113577-6125331;5:113577-6244090;5:113577-7946262;5:113577-8876045;5:113578-16952167;5:140475-26906925;5:140475-9792158;5:218462-1295161;5:218465-1297488;5:218472-1816030;5:218472-1895829 1.35;0.54;0.47;0.47;0.45;0.42;0.40;3.82;0.32;0.32;0.30;2.98;0.25;0.25;0.24;0.23;0.22;0.21;0.20;0.20;0.20;0.20;0.19;0.19;0.19;0.19;1.83;0.17;0.16;1.59;1.52;0.15;1.30;1.27;1.16;1.12;1.07;1.06;0.89;0.88;0.83;0.75;0.54;0.28;0.29;0.18;0.17;1.99;1.87;0.48;0.34;0.18;1.36;1.31;0.97;0.24;0.35;0.24;0.94;0.54;0.51;0.46;0.37;0.37;0.35;0.34;3.37;3.16;0.28;0.23;0.23;0.22;0.21;0.20;0.16;1.32;1.28;1.28;1.06;1.02;0.97;0.93;0.90;0.88;0.69;0.61;0.32;0.20;0.56;5.00;4.99;3.37;3.21 DDD:16279;DDD:16284;dgv131e203 5:653582-875018;5:686604-840273;5:708603-865477 0.1231 DDD:16279;DDD:16284;dgv1000e199;dgv131e203 5:653582-875018;5:682475-788359;5:686604-840273;5:708603-865477 0.0497 5:714989-733938 1000g;5:714989-733938 1000g;5:717638-748444 DDD:16285;5:757677-778933 1000g;5:757677-778933 dgv1062e214;5:686604-840273 DDD:16279;5:763398-838450 DDD:16291 5:754156-754733 gnomAD-SV_v2.1_DUP_5_14078;5:714989-733938 1000g;5:714989-733938 dgv1061e214;5:757677-778933 1000g;5:757677-778933 1000g;5:653582-875018 dgv131e203;5:708603-865477 DDD:16284 5:747846-753492 esv2673755;5:749034-749137 CMRI:2_pbsv.DEL.107_duplicate2;5:765059-765177 CMRI:0_pbsv.DEL.65_duplicate1;5:774678-774737 CMRI:20_pbsv.DEL.131_duplicate2;5:714989-733938 1000g;5:747151-776399 DDD:16288;5:757677-778933 esv3603772;5:682475-788359 dgv1000e199;5:708603-865477 DDD:16284; 5:725332-725427 CMRI:11_pbsv.DEL.181_duplicate1;5:746785-746860 CMRI:32_pbsv.DEL.115_duplicate1;5:751549-751618 CMRI:1_pbsv.DEL.73_duplicate2;5:765178-765296 CMRI:20_pbsv.DEL.130;5:774824-774883 CMRI:0_pbsv.DEL.66_duplicate3;5:714989-733938 esv3603766;5:757677-778933 1000g;5:653582-875018 dgv131e203;5:686604-840273 DDD:16279;5:763398-838450 DDD:16291 653823;654500;654501;659292;663622;663623;663624;664429;664430;664431;665581;673937;673938;673939;682015;685925;697438;697439;703782;709867;744527;744529;774010;778865 gain;loss 0.395 0.580 5:721917-723166 L1ME3F 5:686123-731394 5:770128-777143 98.37 0.535222227518795 -0.0274451648003615 8 3.6787e-13 4.3228e-02 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2L (ZDHHC11B, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 -5_723195_777000_DUP_1 5 723195 777000 53805 DUP Benign NA split p15.33 ZDHHC11B NM_001351303 710469 784844 53806 1058 94 yes 14 intron1-intron12 5'UTR-CDS 6214 3' 723194 777000 DDD:16279;DDD:16284;dgv131e203 5:653582-875018;5:686604-840273;5:708603-865477 0.1231 DDD:16279;DDD:16284;dgv1000e199;dgv131e203 5:653582-875018;5:682475-788359;5:686604-840273;5:708603-865477 0.0497 653823;654500;654501;659292;663622;663623;663624;664429;664430;664431;665581;673937;673938;673939;682015;685925;697438;697439;703782;709867;744527;744529;774010;778865 gain;loss 98.37 0.535222227518795 -0.0274451648003615 8 3.6787e-13 4.3228e-02 full=3 -8_141035364_141061798_DEL_1 8 141035364 141061798 -26434 DEL DI AR Pathogenic NA full q24.3 TRAPPC9 1 KCNK9 (morbid/RE=GH_Enhancer) dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161801;nssv15777239;dbVar:nssv15161417;nssv15161657;dbVar:nssv15161846;dbVar:nssv15169210;dbVar:nssv15161105;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161087;dbVar:nssv15161426;dbVar:nssv15161357;dbVar:nssv15777249;dbVar:nssv17970300;dbVar:nssv15161337;dbVar:nssv15161103;dbVar:nssv15161374;dbVar:nssv15161674;dbVar:nssv15161669;dbVar:nssv15161791;dbVar:nssv15161680;dbVar:nssv15161065;dbVar:nssv17976072;dbVar:nssv15161091;dbVar:nssv15161853;dbVar:nssv15161352;dbVar:nssv15161104;dbVar:nssv15161722;dbVar:nssv15161428;dbVar:nssv16208199;dbVar:nssv15162410;dbVar:nssv15773510;dbVar:nssv15774288;dbVar:nssv15161330;dbVar:nssv15161750;dbVar:nssv16206976;dbVar:nssv15161266;dbVar:nssv17970325;dbVar:nssv15131822;dbVar:nssv15161331;dbVar:nssv15143620;dbVar:nssv15161849;dbVar:nssv15775349;dbVar:nssv15161867;dbVar:nssv15775091;dbVar:nssv15161075;dbVar:nssv15161551 8:10214-146293414;8:13939-146304022;8:158049-146295771;8:158050-146295771;8:158992-146280828;8:164985-146293414;8:176453-146294098;8:191531-146274835;8:191531-146280020;8:191606-146280167;8:12491000-146295771;8:21149034-146295771;8:31936552-146295771;8:70382991-146295771;8:78392287-146294098;8:79526313-146280020;8:86778229-146295771;8:86841155-146295771;8:86841229-142689874;8:88943381-146294098;8:93047483-141355635;8:95694383-146294042;8:96496504-146295711;8:98395102-146295771;8:98432251-146222672;8:101879572-146295771;8:104318565-146294098;8:114592632-146280020;8:114853127-146295771;8:121042468-146295771;8:121694650-146295771;8:122193547-146295771;8:125496224-146295771;8:125510740-146294098;8:125526332-146280020;8:128877996-146295771;8:129233159-146274835;8:130863094-146295771;8:131127765-142238309;8:131651429-146294098;8:131682564-146280020;8:134825278-146280828;8:136059860-146295771;8:136378790-146295771;8:139188798-146295771;8:140016462-146274835;8:140249068-146294098 0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.03;0.04;0.04;0.04;0.04;0.05;0.05;0.05;0.05;0.05;0.06;0.06;0.06;0.06;0.08;0.08;0.10;0.11;0.11;0.13;0.13;0.13;0.15;0.16;0.17;0.24;0.18;0.18;0.23;0.26;0.27;0.37;0.42;0.44 Intellectual developmental disorder, AR 13, 613192 (3) AR dbVar:nssv16208202;dbVar:nssv15127815;morbid:TRAPPC9 8:126892815-143750028;8:127638607-144388560;8:140739968-141468678 0.16;0.16;3.63 8:141048063-141048063 1000g 0.535 0.380 8:141035378-141035461;8:141035462-141035486 MER58C;(CAAAA)n 53.39 0.107633755409335 -1.97676981971355 -1.34878674017516 -0.190632175596259 1.58912949219012 611966 yes 3 2.2898e-14 5.7604e-06 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 -8_141035364_141061798_DEL_1 8 141035364 141061798 -26434 DEL DI AR Pathogenic NA split q24.3 TRAPPC9 NM_001160372 140739967 141467843 26435 0 0 no 23 intron17-intron17 CDS 1187 3' 141035363 141061798 30 0 53.39 0.107633755409335 -1.97676981971355 -1.34878674017516 -0.190632175596259 1.58912949219012 autosomal recessive non-syndromic intellectual disability;intellectual disability, autosomal recessive 13;intellectual disability-obesity-brain malformations-facial dysmorphism syndrome AR Definitive;Moderate;Strong;Supportive 17120046;2000476;20004763;20004764;20004765;20004765[PMID]_20004763[PMID]_20004765[PMID];22549410;22549410[PMID] 611966 Intellectual developmental disorder, AR 13, 613192 (3) AR AR yes 3 2.2898e-14 5.7604e-06 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA full q11.2-q11.1 CHEK2P2;CXADRP2;FAM30C;GOLGA6L1;GOLGA6L22;GOLGA6L6;GOLGA8CP;GOLGA8DP;HERC2P3;IGHV1OR15-1;IGHV1OR15-3;LINC01193;LINC02203;LOC101927079;LOC102723534;LOC102723623;LOC102724760;LOC642131;LOC646214;MIR1268A;MIR3118-2;MIR3118-3;MIR3118-4;MIR4509-1;MIR4509-2;MIR4509-3;MIR5701-1;MIR5701-2;MIR5701-3;NBEAP1;NF1P2;OR4M2;OR4N3P;OR4N4;OR4N4C;POTEB;POTEB2;POTEB3;REREP3 39 ADAM22 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AIP (morbid/RE=mTL_miRNA);BLOC1S3 (morbid/RE=mTL_miRNA);CA12 (morbid/RE=mTL_miRNA);CACNA1H (morbid/RE=mTL_miRNA);CAMK2G (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CERS1 (morbid/RE=mTL_miRNA);DHCR7 (morbid/RE=mTL_miRNA);DICER1 (HI=3/morbid/RE=mTL_miRNA);EDAR (morbid/RE=mTL_miRNA);EGLN1 (morbid/RE=mTL_miRNA);EPB41 (morbid/RE=mTL_miRNA);EPHA2 (morbid/RE=mTL_miRNA);ERBB3 (morbid/RE=mTL_miRNA);FRMPD4 (morbid/RE=mTL_miRNA);GABRB2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GCK (morbid/RE=mTL_miRNA);HPRT1 (HI=3/morbid/RE=mTL_miRNA);HRAS (morbid/RE=mTL_miRNA);HSPD1 (morbid/RE=mTL_miRNA);IL6ST (morbid/RE=mTL_miRNA);INF2 (morbid/RE=mTL_miRNA);ISCU (morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNJ10 (morbid/RE=mTL_miRNA);KIF23 (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);LRIG2 (morbid/RE=mTL_miRNA);MAPK1 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);NDUFS1 (morbid/RE=mTL_miRNA);NEK9 (morbid/RE=mTL_miRNA);NPM1 (morbid/RE=mTL_miRNA);ORAI1 (morbid/RE=mTL_miRNA);PEX26 (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);PRKCA (morbid/RE=mTL_miRNA);PRLR (morbid/RE=mTL_miRNA);PURA (HI=3/morbid/RE=mTL_miRNA);RAC3 (morbid/RE=mTL_miRNA);SCN1A (HI=3/morbid/RE=mTL_miRNA);SGPL1 (morbid/RE=mTL_miRNA);SH2D1A (HI=3/morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC24A4 (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SLC7A14 (morbid/RE=mTL_miRNA);SLC7A7 (morbid/RE=mTL_miRNA);SMAD4 (HI=3/morbid/RE=mTL_miRNA);SMAD6 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SMOC2 (morbid/RE=mTL_miRNA);SNAI2 (morbid/RE=mTL_miRNA);SOX17 (morbid/RE=mTL_miRNA);TBL1XR1 (HI=3/morbid/RE=mTL_miRNA);TRIP11 (morbid/RE=mTL_miRNA);TTC37 (morbid/RE=mTL_miRNA);TULP1 (morbid/RE=mTL_miRNA);WDR81 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA);ZNF711 (morbid/RE=mTL_miRNA) dbVar:nssv15172447;dbVar:nssv15149081;dbVar:nssv15148902;dbVar:nssv15125410;dbVar:nssv15127689;dbVar:nssv15127462;dbVar:nssv15126524;dbVar:nssv15124656;dbVar:nssv15127659;dbVar:nssv15126021;dbVar:nssv15172190;dbVar:nssv15150569;dbVar:nssv15147052;dbVar:nssv15145742;dbVar:nssv15147053;dbVar:nssv15175556;dbVar:nssv15145744;dbVar:nssv15774514;dbVar:nssv15148785;dbVar:nssv15605894;dbVar:nssv15149135;dbVar:nssv15148575;dbVar:nssv15147687;dbVar:nssv15605895;dbVar:nssv15147058;dbVar:nssv15145747;dbVar:nssv15146452;dbVar:nssv15149084;dbVar:nssv15147355;dbVar:nssv15149616;dbVar:nssv15147801;dbVar:nssv15146958;dbVar:nssv15149124;dbVar:nssv15123304;dbVar:nssv15147513;dbVar:nssv15127079;dbVar:nssv15605897;dbVar:nssv15605899;dbVar:nssv15125414;dbVar:nssv15148135;dbVar:nssv15146406;dbVar:nssv15148053;dbVar:nssv15145661;nssv15146195;dbVar:nssv15145807;dbVar:nssv15147309;dbVar:nssv15145805;nssv15146672;dbVar:nssv15145677;dbVar:nssv16207640;dbVar:nssv16215281;dbVar:nssv15755702;dbVar:nssv15145809;nssv15150756;dbVar:nssv15145849;dbVar:nssv15146718;dbVar:nssv15148834;dbVar:nssv15147450;nssv15148847;dbVar:nssv15146035;dbVar:nssv15148907;dbVar:nssv15146735;dbVar:nssv15148824;dbVar:nssv15146042;dbVar:nssv15147411;dbVar:nssv15147985;dbVar:nssv15148007;dbVar:nssv15146680;dbVar:nssv15147424;dbVar:nssv15148131;dbVar:nssv15145909 15:20016812-102493540;15:20044343-28924405;15:20045835-32914140;15:20063341-102521392;15:20063341-29093456;15:20063341-29209620;15:20063341-30448351;15:20063341-32439302;15:20063341-32942613;15:20063341-32986584;15:20071674-102461162;15:20071674-30737344;15:20085003-28947309;15:20085003-29210720;15:20085004-28178425;15:20102541-29031690;15:20110723-28408897;15:20179528-32998070;15:20190549-28406650;15:20190549-30300265;15:20190549-32386089;15:20190549-32917801;15:20190549-32917857;15:20191653-28525310;15:20207714-30641396;15:20207714-32413623;15:20251769-28631040;15:20306550-26208861;15:20686197-30509384;15:20733396-102511616;15:20733396-28406650;15:20733396-28406709;15:20848461-27662530;15:21129985-28535266;15:22304597-28577787;15:22318645-29209620;15:22382861-32396457;15:22383300-32917689;15:22409402-28952953;15:22652061-28883749;15:22669053-28435888;15:22698523-28940098;15:22698523-29030517;15:22698523-29085896;15:22698523-30366124;15:22698523-30653936;15:22698523-32899558;15:22750306-23114374;15:22750306-23164315;15:22750306-23226254;15:22765629-28520313;15:22765629-28557186;15:22765629-28559402;15:22765629-28912057;15:22765629-29006852;15:22765629-29085896;15:22765629-29096442;15:22765629-30366124;15:22765629-30653936;15:22765629-30819509;15:22765629-38837526;15:22765638-28520316;15:22765638-29085888;15:22765638-30366079;15:22765638-31467435;15:22765638-32509932;15:22765638-32899558 2.83;26.27;18.13;2.83;25.83;25.51;22.46;18.85;18.11;18.05;2.83;21.87;26.32;25.56;28.82;26.13;28.11;18.20;28.39;23.08;19.13;18.33;18.33;27.99;22.36;19.11;27.84;39.52;21.17;2.49;26.49;26.49;28.14;22.09;7.35;6.49;3.82;3.63;5.44;1.82;1.68;1.08;1.06;1.05;0.88;0.84;0.66;4.23;3.72;3.23;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00 dbVar:nssv16865885;dbVar:nssv15605896;dbVar:nssv15123310;dbVar:nssv16208656;dbVar:nssv16215320;dbVar:nssv15147060;dbVar:nssv15146946;dbVar:nssv15147062;dbVar:nssv15153078;dbVar:nssv15160814;dbVar:nssv15160813;dbVar:nssv15159751;dbVar:nssv15160812;dbVar:nssv16216734;dbVar:nssv16297059;dbVar:nssv15147987;dbVar:nssv16215225;dbVar:nssv16208660;dbVar:nssv15160288;dbVar:nssv15146407;dbVar:nssv15145750;dbVar:nssv16297060;dbVar:nssv15149692;dbVar:nssv15147712;dbVar:nssv15145753;dbVar:nssv15147316;dbVar:nssv15145752;nssv15148282;dbVar:nssv15146196;nssv15146797;dbVar:nssv15146673;dbVar:nssv15147319;dbVar:nssv17955873;dbVar:nssv15145025;dbVar:nssv15145441;dbVar:nssv15145201;dbVar:nssv17517455;dbVar:nssv16297061;dbVar:nssv16208668;dbVar:nssv15129123;dbVar:nssv16215325;dbVar:nssv15130100;dbVar:nssv16209033;dbVar:nssv15172201;dbVar:nssv15606130;dbVar:nssv15132915;nssv16736610;dbVar:nssv16736624;nssv16736646;dbVar:nssv16091751;dbVar:nssv15130140;dbVar:nssv15146040;dbVar:nssv15148147;dbVar:nssv15146043;dbVar:nssv15145953;dbVar:nssv15148915;dbVar:nssv15148857;dbVar:nssv15146645 15:20612841-23272733;15:20848751-32925141;15:21129985-32514926;15:21903816-23272733;15:22299435-23226254;15:22318598-28940098;15:22427967-23226254;15:22432629-30641396;15:22503622-23091180;15:22646195-23191269;15:22646195-23199953;15:22646195-23302626;15:22646195-23428906;15:22646693-28964445;15:22646800-23301267;15:22652048-28705151;15:22652331-23226254;15:22652331-23272733;15:22652331-29050198;15:22669053-28435888;15:22669053-30401486;15:22695843-23300942;15:22698523-28406650;15:22698523-28406709;15:22698523-28520313;15:22698523-28557186;15:22698523-28691460;15:22698523-29030517;15:22698523-29085896;15:22698523-38381783;15:22743128-23246000;15:22746945-23102836;15:22746945-23121448;15:22746945-23199421;15:22746949-23323445;15:22749636-23301317;15:22750306-23109890;15:22750306-23164315;15:22750306-23222284;15:22750306-23226254;15:22750306-23272733;15:22750306-28535266;15:22751195-23251194;15:22765629-23085096;15:22765629-23191062;15:22765629-23217514;15:22765629-23300287;15:22765629-28559402;15:22765629-28691460;15:22765629-28912057;15:22765629-28940098;15:22765629-28976193;15:22765629-32676855;15:22765638-29085888 80.94;15.87;14.37;62.96;50.31;6.75;42.31;4.06;44.60;21.92;21.58;18.20;15.27;1.88;18.17;1.88;19.75;18.27;1.77;1.68;1.25;11.54;1.18;1.18;1.15;1.15;1.12;1.06;1.05;0.43;4.49;5.27;5.00;4.14;3.25;2.91;4.28;3.72;3.26;3.23;2.94;0.27;2.90;0.02;0.01;0.01;0.01;0.00;0.00;0.00;0.00;0.00;0.00;0.00 dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764 0.1500 dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284 0.1000 15:20717000-20724000 gnomAD-SV_v2.1_DUP_15_39413;15:20746872-20747023 DDD:44052;15:20989050-20994350 gnomAD-SV_v2.1_DUP_15_39424;15:21315923-21318351 CMRI:10_pbsv.SPLIT.DUP.48;15:22170840-22170894 CMRI:5_pbsv.INS.DUP.71_duplicate2;15:22336905-22343964 1000g;15:22336905-22343964 1000g;15:22364338-22364338 1000g;15:22417961-22417961 1000g;15:20545495-20547443 CMRI:0_pbsv.SPLIT.DUP.36;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20730500-20754075 gnomAD-SV_v2.1_DUP_15_39415;15:20735000-20745000 gnomAD-SV_v2.1_DUP_15_39417;15:20783000-20799000 gnomAD-SV_v2.1_DUP_15_39419;15:20807000-20821500 gnomAD-SV_v2.1_DUP_15_39421;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20935077-20960284 nsv514764... 15:20436917-20436981 CMRI:11_pbsv.INS.DUP.45_duplicate2;15:20729300-20736525 gnomAD-SV_v2.1_DUP_15_39414;15:20958000-20967125 gnomAD-SV_v2.1_DUP_15_39422;15:21301350-21312400 gnomAD-SV_v2.1_DUP_15_39426;15:21941251-21941251 1000g;15:22336905-22343964 1000g;15:22336905-22343964 1000g;15:22336905-22343964 dgv434e214;15:22415114-22415114 1000g;15:22574177-22574177 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 dgv430e214;15:20731675-20778150 gnomAD-SV_v2.1_DUP_15_39416;15:20749534-20773538 DDD:44053;15:20786000-20827000 gnomAD-SV_v2.1_DUP_15_39420;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20846722-20867075 dgv431e214... 15:20468142-20468256 DDD:44028;15:20515316-20515395 CMRI:2_pbsv.DEL.60_duplicate9;15:20545815-20546034 CMRI:83_pbsv.DEL.38_duplicate10;15:20545831-20545958 CMRI:11_pbsv.DEL.63_duplicate7;15:20546561-20546672 CMRI:9_pbsv.DEL.40_duplicate7;15:20546886-20546937 CMRI:7_pbsv.DEL.52_duplicate7;15:20546993-20547061 CMRI:3_pbsv.DEL.50_duplicate9;15:20547071-20547132 CMRI:3_pbsv.DEL.51_duplicate6;15:20547131-20547199 CMRI:10_pbsv.DEL.37_duplicate4;15:20547250-20547366 CMRI:1_pbsv.DEL.34_duplicate6;15:20547458-20547664 CMRI:20_pbsv.DEL.53_duplicate1;15:20547957-20548087 CMRI:43_pbsv.DEL.46_duplicate5;15:20548661-20548740 CMRI:17_pbsv.DEL.72_duplicate7;15:20548980-20549074 CMRI:1_pbsv.DEL.35_duplicate5;15:20549170-20549238 CMRI:5_pbsv.DEL.56_duplicate5;15:20587419-20587601 gnomAD-SV_v2.1_DEL_15_145824;15:20587443-20587601 CMRI:2_pbsv.DEL.80_duplicate11;15:20649714-20649821 CMRI:107_pbsv.DEL.47_duplicate8;15:20698000-20706500 gnomAD-SV_v2.1_DEL_15_145825;15:20734328-20735311 CMRI:22_pbsv.DEL.64_duplicate9;15:20739871-20740113 CMRI:15_pbsv.DEL.58_duplicate7... 15:20452912-20452963 CMRI:2_pbsv.DEL.52_duplicate7;15:20514311-20514511 CMRI:1_pbsv.DEL.26_duplicate1;15:20545403-20545453 CMRI:3_pbsv.DEL.48_duplicate5;15:20545815-20546935 CMRI:1_pbsv.DEL.31_duplicate9;15:20546105-20546227 CMRI:20_pbsv.DEL.43_duplicate4;15:20546656-20546839 CMRI:28_pbsv.DEL.54_duplicate4;15:20546976-20547062 CMRI:20_pbsv.DEL.45_duplicate6;15:20547019-20547089 CMRI:0_pbsv.DEL.38_duplicate7;15:20547100-20547159 CMRI:21_pbsv.DEL.52_duplicate7;15:20547178-20548188 CMRI:1_pbsv.DEL.33_duplicate5;15:20547256-20548722 CMRI:12_pbsv.DEL.40_duplicate7;15:20547652-20547817 CMRI:22_pbsv.DEL.54_duplicate8;15:20548017-20548203 CMRI:8_pbsv.DEL.54_duplicate6;15:20548742-20548830 CMRI:11_pbsv.DEL.66_duplicate8;15:20549098-20549157 CMRI:3_pbsv.DEL.53_duplicate8;15:20581464-20589613 esv2674516;15:20580644-20589857 CMRI:0_pbsv.DEL.41_duplicate6;15:20644488-20644611 CMRI:86_pbsv.DEL.61_duplicate4;15:20649904-20649957 CMRI:2_pbsv.DEL.83_duplicate6;15:20732300-20738500 gnomAD-SV_v2.1_DEL_15_145827;15:20739577-20739744 CMRI:4_pbsv.DEL.58_duplicate1... 1015796;1015797;1015798;1015799;1015998;1015999;1016000;1016001;1016239;1016240;1016241;1016243;1016617;1016618;1016982;1016983;1017230;1017232;1017234;1018200;1018201;1018423;1018424;1018674;1018675;1019187;1019431;1019697;1020681;1022556;1022557;1023826;1024061;1024062;1026886;1041478;1044061;1075159;1080050;1084769;1088979;1102049;1104581;1124636;1166850;1206046;1209798;1220163;1227773;1232239;1248784;... gain;loss 0.380 0.455 15:22765220-22765620;15:22765771-22766019 L1MC4;L2 15:20345908-20498625;15:20390971-20432871 15:22754054-22770109 15:20200401-22365100 High Signal Region 93.81 2.22375841006203 2.58284576037233 8 3.5277e-01 5.7189e-01 -0.55 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);3B (39 genes, +0.45);5F (+0.00) 3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.1 CHEK2P2 NR_038836 20487996 20496811 8815 0 0 no 6 txStart-txEnd UTR 20487996 20496811 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 CXADRP2 NR_024387 22014420 22016878 2458 0 0 no 1 txStart-txEnd UTR 22014420 22016878 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 FAM30C NR_145444 21208605 21255165 46560 0 0 no 4 txStart-txEnd UTR 21208605 21255165 DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55;esv3892595 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA6L1 NM_001001413 22736245 22746002 9757 2007 100 no 9 txStart-txEnd 5'UTR-3'UTR 22736245 22746002 dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764 0.1500 dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284 0.1000 93.48 8 2.3586e-12 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA6L22 NM_001271664 22736267 22746002 9735 1971 100 no 11 txStart-txEnd 5'UTR-3'UTR 22736267 22746002 dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764 0.1500 dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284 0.1000 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA6L6 NM_001145004 20737093 20747114 10021 2171 100 yes 12 txStart-txEnd 5'UTR-3'UTR 20737093 20747114 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;gnomAD-SV_v2.1_DUP_15_39415;gnomAD-SV_v2.1_DUP_15_39416 15:20730500-20754075;15:20731675-20778150;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 93.81 0.630577750419089 0.0606178603183018 8 2.2875e-19 8.6864e-02 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA8CP NR_027411 20767673 20781026 13353 0 0 no 18 txStart-txEnd UTR 20767673 20781026 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA8DP NR_027407 22702284 22715728 13444 0 0 no 18 txStart-txEnd UTR 22702284 22715728 DDD:44147;DDD:44168;dgv40e203;dgv93e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-22869764 0.1500 DDD:44147;DDD:44168;dgv40e203;dgv94e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-23222284 0.1000 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2-q11.1 HERC2P3 NR_036432 20613649 20711433 97784 0 0 no 26 txStart-txEnd UTR 20613649 20711433 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 IGHV1OR15-1 NR_135694 22448239 22448881 642 0 0 no 2 txStart-txEnd UTR 22448239 22448881 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44129;dgv2191n100;dgv3e224;dgv40e203;dgv438e214;dgv92e55;dgv93e55;nsv514767 15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22411349-22577661;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44129;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:22411349-22577661;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 IGHV1OR15-3 NR_135666 22465805 22466547 742 0 0 no 2 txStart-txEnd UTR 22465805 22466547 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;dgv2191n100;dgv3e224;dgv40e203;dgv438e214;dgv92e55;dgv93e55;nsv514767 15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22411349-22577661;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44129;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LINC01193 NR_040094 21145766 21198633 52867 0 0 no 5 txStart-txEnd UTR 21145766 21198633 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LINC02203 NR_015416 22278009 22371088 93079 0 0 no 11 txStart-txEnd UTR 22278009 22371088 DDD:44001;DDD:44096;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55 15:22267463-22591752;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC101927079 NR_110480 22278030 22383564 105534 0 0 no 9 txStart-txEnd UTR 22278030 22383564 DDD:44001;DDD:44096;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55 15:22267463-22591752;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 661973;664511;665411;669653;681562;688758;690131;701704;718266;747790 loss full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC102723534 NR_160687 20711668 20727150 15482 0 0 no 5 txStart-txEnd UTR 20711668 20727150 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;gnomAD-SV_v2.1_DUP_15_39412 15:20706000-20747000;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC102723623 NM_001382446 22736175 22745998 9823 1935 100 no 11 txStart-txEnd 5'UTR-3'UTR 22736175 22745998 dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764 0.1500 dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284 0.1000 740239 loss full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC102724760 NR_135695 22448239 22448881 642 0 0 no 2 txStart-txEnd UTR 22448239 22448881 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44129;dgv2191n100;dgv3e224;dgv40e203;dgv438e214;dgv92e55;dgv93e55;nsv514767 15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22411349-22577661;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44129;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:22411349-22577661;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC642131 NR_135667 22465805 22466547 742 0 0 no 2 txStart-txEnd UTR 22465805 22466547 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;dgv2191n100;dgv3e224;dgv40e203;dgv438e214;dgv92e55;dgv93e55;nsv514767 15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22411349-22577661;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44129;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC646214 NR_027053 21932513 21940739 8226 0 0 no 1 txStart-txEnd UTR 21932513 21940739 DDD:44001;DDD:44096;DDD:44097;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:21904679-21949433;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44097;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:21904679-21949433;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR1268A NR_031672 22513228 22513280 52 0 0 no 1 txStart-txEnd UTR 22513228 22513280 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22411349-22577661;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 CMRI:2_pbsv.DEL.105_duplicate9;DDD:44001;DDD:44096;DDD:44113;DDD:44129;DDD:44139;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22513214-22513523;15:22475646-22537915;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR3118-2 NR_036062 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR3118-3 NR_036063 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR3118-4 NR_036134 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR4509-1 NR_039732 22675147 22675241 94 0 0 no 1 txStart-txEnd UTR 22675147 22675241 DDD:44147;DDD:44168;dgv40e203;dgv93e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-22869764 0.1500 DDD:44147;DDD:44168;dgv40e203;dgv94e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-23222284 0.1000 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR4509-2 NR_039733 22675147 22675241 94 0 0 no 1 txStart-txEnd UTR 22675147 22675241 DDD:44147;DDD:44168;dgv40e203;dgv93e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-22869764 0.1500 DDD:44147;DDD:44168;dgv40e203;dgv94e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-23222284 0.1000 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR4509-3 NR_039734 22675147 22675241 94 0 0 no 1 txStart-txEnd UTR 22675147 22675241 DDD:44147;DDD:44168;dgv40e203;dgv93e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-22869764 0.1500 DDD:44147;DDD:44168;dgv40e203;dgv94e55 15:22519942-22726364;15:22650162-22738662;15:20016329-23487546;15:20167087-23222284 0.1000 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR5701-1 NR_049886 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21145102-21164300;15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR5701-2 NR_049895 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21145102-21164300;15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR5701-3 NR_128721 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21145102-21164300;15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 NBEAP1 NR_027992 20874796 20961480 86684 0 0 no 3 txStart-txEnd UTR 20874796 20961480 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 NF1P2 NR_028506 22133180 22145802 12622 0 0 no 8 txStart-txEnd UTR 22133180 22145802 DDD:44001;DDD:44096;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4M2 NM_001004719 22368477 22369561 1084 942 95 no 1 txStart-txEnd 5'UTR-3'UTR 22368477 22369561 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dgv2191n100;dgv3e224;dgv40e203;dgv435e214;dgv92e55;dgv93e55;nsv514767 15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22360686-22387071;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22360686-22387071;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 76.23 9 3.9447e-08 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4N3P NR_028067 22413461 22414395 934 0 0 no 1 txStart-txEnd UTR 22413461 22414395 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44129;dgv2191n100;dgv3e224;dgv40e203;dgv437e214;dgv92e55;dgv93e55;nsv514767 15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22383478-22434169;15:22383478-22434169;15:22383478-22434169;15:22383478-22434169;15:22383478-22434169;15:22411349-22577661;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44129;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:22411349-22577661;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4N4 NM_001005241 22382381 22383815 1434 951 70 no 1 txStart-txEnd 5'UTR-3'UTR 22382381 22383815 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:22360686-22387071;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22360686-22387071;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 75.33 -0.271906921498889 -0.565772314050669 9 5.1332e-05 1.8051e-02 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4N4C NM_001365389 22369147 22383572 14425 1002 100 no 2 txStart-txEnd 5'UTR-3'UTR 22369147 22383572 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:22360686-22387071;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22360686-22387071;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 664511;688758;701704;718266;747790 loss full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 POTEB NM_001277304 22051852 22083259 31407 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22051852 22083259 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 91.86 9 3.5277e-01 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 POTEB2 NM_001277303 22051852 22082803 30951 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22051852 22082803 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 92.58 2.22375841006203 2.58284576037233 8 4.2457e-02 5.7189e-01 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 POTEB3 NM_207355 22048289 22083259 34970 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22048289 22083259 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 full=3 -15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 REREP3 NR_033735 22546564 22570831 24267 0 0 no 3 txStart-txEnd UTR 22546564 22570831 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;DDD:44147;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22411349-22577661;15:22519942-22726364;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44129;DDD:44147;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;15:22519942-22726364;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=3 -1_149041934_149209289_DEL_1 1 149041934 149209289 -167355 DEL Benign NA full q21.2 NBPF25P;RNVU1-17 2 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15140065;dbVar:nssv15127264;dbVar:nssv15140622;dbVar:nssv15142143;dbVar:nssv15139736;dbVar:nssv15136257;dbVar:nssv15137789;dbVar:nssv15135435;dbVar:nssv15132352;dbVar:nssv15127572;dbVar:nssv16736643;dbVar:nssv15135787;dbVar:nssv15121048;dbVar:nssv15132855 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:143500224-149763815;1:143544036-149754161;1:143753741-151399970;1:143932351-149801420;1:144927579-153223600;1:145425396-149091187;1:145425396-149699420;1:145425396-149768855;1:145451330-156102366;1:145764500-249233096;1:145818703-149378266;1:146500973-149433185;1:147400638-149813625;1:147411535-149699420 0.07;0.07;0.07;2.67;2.69;2.19;2.85;2.02;1.34;3.92;3.85;1.57;0.16;4.70;5.71;6.94;7.31 dbVar:nssv15132982;dbVar:nssv15133379;dbVar:nssv15137633;dbVar:nssv15137132;dbVar:nssv15136850;dbVar:nssv15132445;dbVar:nssv15137470;dbVar:nssv15135169;dbVar:nssv15129680;dbVar:nssv15157514;dbVar:nssv15133691;dbVar:nssv15132524;dbVar:nssv15137778 1:143721527-149232481;1:145388356-149418924;1:145415157-149433207;1:145626238-149244468;1:145626238-149453964;1:145655993-149232481;1:145747243-149155026;1:145987157-149232481;1:146053395-249233096;1:146089269-149376652;1:146143190-149232481;1:146143190-149699420;1:146507650-149433207 3.04;4.15;4.17;4.63;4.37;4.68;3.32;5.16;0.16;5.09;5.42;4.71;5.72 DDD:2784;DDD:2806;TS40:ISCA-37469;dgv4e203;nsv514006 1:149034710-149405578;1:149036513-149244464;1:147929337-149801433;1:148050780-149739249;1:148867552-149768855 0.0800 DDD:2784;DDD:2806;HI40:ISCA-37469;dgv375n100;dgv4e203;esv2422083;esv3894145 1:149034710-149405578;1:149036513-149278459;1:149036525-149256691;1:149039121-149211496;1:147929337-149801433;1:148050780-149739249;1:148867552-149768855 0.3041 1:149207861-149218152 esv3587472;1:149036513-149244464 nsv514006;1:149071635-149169501 esv3587467;1:149151839-149203736 esv3587470;1:148050780-149739249 DDD:2784; 1:149207861-149218152 1000g;1:149034710-149405578 DDD:2806;1:149071635-149169501 1000g;1:149151839-149203736 1000g;1:147929337-149801433 dgv4e203;1:148867552-149768855 TS40:ISCA-37469 1:149090850-149092378 esv3587468;1:149151330-149151379 CMRI:18_pbsv.DEL.2013;1:149064634-149080509 gnomAD-SV_v2.1_DEL_1_7837;1:149207861-149218152 1000g;1:149034710-149405578 DDD:2806;1:149036513-149278459 dgv375n100;1:149039121-149211496 esv3894145;1:149071635-149169501 esv3587466;1:149145234-149244654 DDD:2814;1:149151839-149203736 esv3587469;1:149202746-149436842 DDD:2817;1:148050780-149739249 DDD:2784; 1:149090850-149092378 1000g;1:149132818-149132944 CMRI:66_pbsv.DEL.2036;1:149035900-149053900 gnomAD-SV_v2.1_DEL_1_7834;1:149207852-149218151 HI40:ISCA-46571;1:149207861-149218152 esv3587471;1:149035900-149204000 gnomAD-SV_v2.1_DEL_1_7835;1:149036525-149256691 esv2422083;1:149071635-149169501 1000g;1:149134000-149204000 gnomAD-SV_v2.1_DEL_1_7844;1:149151839-149203736 1000g;1:149152065-149204067 HI40:ISCA-46570;1:147929337-149801433 dgv4e203;1:148867552-149768855 HI40:ISCA-37469 0.455 0.440 1:149209192-149209220 (GA)n 1:149035966-149106186 1:149191324-149214601;1:149200001-149214601 1:147832001-149058800 High Signal Region -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (2 genes, +0.00);5F (+0.00) 1 -1_149041934_149209289_DEL_1 1 149041934 149209289 -167355 DEL Benign NA split q21.2 NBPF25P NR_104217 148250249 149109725 67792 0 0 no 18 txStart-intron2 UTR 67049 5' 149041933 149109725 DDD:2784;DDD:2806;TS40:ISCA-37469;dgv4e203;nsv514006 1:149034710-149405578;1:149036513-149244464;1:147929337-149801433;1:148050780-149739249;1:148867552-149768855 0.0800 DDD:2784;DDD:2806;HI40:ISCA-37469;dgv375n100;dgv4e203;esv2422083;esv3894145;gnomAD-SV_v2.1_DEL_1_7835 1:149034710-149405578;1:149035900-149204000;1:149036513-149278459;1:149036525-149256691;1:149039121-149211496;1:147929337-149801433;1:148050780-149739249;1:148867552-149768855 0.3041 full=1 -1_149041934_149209289_DEL_1 1 149041934 149209289 -167355 DEL Benign NA split q21.2 RNVU1-17 NR_104078 149194105 149194269 164 0 0 no 1 txStart-txEnd UTR 149194105 149194269 1000g;DDD:2784;DDD:2806;TS40:ISCA-37469;dgv4e203;esv3587470;nsv514006 1:149034710-149405578;1:149036513-149244464;1:149151839-149203736;1:149151839-149203736;1:147929337-149801433;1:148050780-149739249;1:148867552-149768855 0.0800 1000g;DDD:2784;DDD:2806;DDD:2814;HI40:ISCA-37469;HI40:ISCA-46570;dgv375n100;dgv4e203;esv2422083;esv3587469;esv3894145;gnomAD-SV_v2.1_DEL_1_7835;gnomAD-SV_v2.1_DEL_1_7844 1:149034710-149405578;1:149035900-149204000;1:149036513-149278459;1:149036525-149256691;1:149039121-149211496;1:149134000-149204000;1:149145234-149244654;1:149151839-149203736;1:149151839-149203736;1:149152065-149204067;1:147929337-149801433;1:148050780-149739249;1:148867552-149768855 0.3041 full=1 -1_248738899_248785562_DEL_1 1 248738899 248785562 -46663 DEL Benign NA full q44 OR2T10 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15777262;dbVar:nssv15151024;dbVar:nssv16207620;dbVar:nssv15146793;dbVar:nssv15147003;dbVar:nssv15146656;dbVar:nssv16215284;dbVar:nssv15145669;dbVar:nssv15154064;dbVar:nssv15146178;dbVar:nssv15147314;dbVar:nssv15147005;dbVar:nssv15146390;dbVar:nssv15150211;dbVar:nssv15147383;dbVar:nssv15146391;dbVar:nssv15126459;dbVar:nssv15146018;dbVar:nssv15156411;dbVar:nssv15147341;dbVar:nssv15149590;dbVar:nssv15170725;dbVar:nssv15149119;dbVar:nssv15774642;dbVar:nssv15776729;dbVar:nssv15145719;dbVar:nssv15142850;dbVar:nssv15140102;dbVar:nssv15119915;dbVar:nssv15135164;dbVar:nssv15142418;dbVar:nssv15133070;dbVar:nssv15128248 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:182388774-249111240;1:195483440-249213000;1:204045949-249218992;1:207519988-249224684;1:209819553-249225312;1:210136971-249212668;1:210152795-249218992;1:214197156-249212668;1:218252552-249224684;1:223521036-249212668;1:224002850-249212668;1:224016203-249185508;1:224075483-249185508;1:224105295-249224684;1:224210565-249212668;1:224284191-249212668;1:225049988-249233096;1:225626183-249060210;1:228529974-249181598;1:229158657-249212668;1:231670871-249213000;1:232232336-249218992;1:234050865-249213059;1:235582581-249224684;1:238669294-249224684;1:240407745-249185508;1:242324399-249224684;1:242656461-249213000;1:242992034-249185508;1:243095879-249158835;1:244197792-249224684;1:245476118-249212668;1:245665464-249233096 0.02;0.02;0.02;0.05;0.07;0.09;0.10;0.11;0.12;0.12;0.12;0.13;0.15;0.18;0.19;0.19;0.19;0.19;0.19;0.19;0.19;0.20;0.23;0.23;0.27;0.27;0.31;0.34;0.44;0.53;0.68;0.71;0.75;0.77;0.93;1.25;1.31 dbVar:nssv15129680;dbVar:nssv15149874;dbVar:nssv15148823;dbVar:nssv15148210;dbVar:nssv15148138;dbVar:nssv15148243;dbVar:nssv15146635;dbVar:nssv15146644;dbVar:nssv15146499;dbVar:nssv15146500;dbVar:nssv15145856;dbVar:nssv15153348;dbVar:nssv15146579;dbVar:nssv15131783;dbVar:nssv15138053;dbVar:nssv15124424;dbVar:nssv15126240;dbVar:nssv15133004;dbVar:nssv15771899;dbVar:nssv15133645;dbVar:nssv15153353;dbVar:nssv15605763;dbVar:nssv15772690;dbVar:nssv16255440 1:146053395-249233096;1:235797385-249224684;1:236719383-249212668;1:237806582-249212668;1:238196876-249218733;1:238356181-249224684;1:238514422-249212668;1:238917050-249212666;1:239721731-249212668;1:239793169-249218792;1:240628423-249212668;1:241051171-249224684;1:241210723-249218792;1:241920552-249185508;1:242208582-249224684;1:243103402-249119318;1:243477621-249233096;1:243949932-249212668;1:244379482-249224684;1:244745426-249212668;1:244797640-249224684;1:245341154-249212429;1:246565045-249224684;1:246853200-249181899 0.05;0.35;0.37;0.41;0.42;0.43;0.44;0.45;0.49;0.50;0.54;0.57;0.58;0.64;0.67;0.78;0.81;0.89;0.96;1.04;1.05;1.21;1.75;2.00 DDD:4636;DDD:4639;HI40:ISCA-46339;dgv166e212;dgv630n100;esv2760083;esv2763780;gnomAD-SV_v2.1_DEL_1_13889 1:248605753-248818483;1:248683401-248814080;1:248688222-248828223;1:248693963-248856466;1:248727631-248859425;1:248731000-248798200;1:248731000-248798200;1:248737436-248818471 0.2767 1:248756742-248797597 1000g 1:248742279-248742334 CMRI:11_pbsv.DEL.5370;1:248712455-248757403 gnomAD-SV_v2.1_DEL_1_13885;1:248729000-248743000 gnomAD-SV_v2.1_DEL_1_13888;1:248738000-248744000 gnomAD-SV_v2.1_DEL_1_13890;1:248755656-248758478 1000g;1:248755656-248758478 esv3589558;1:248605753-248818483 esv2760083;1:248688222-248828223 dgv166e212;1:248727631-248859425 DDD:4639;1:248731000-248798200 gnomAD-SV_v2.1_DEL_1_13889;1:248739346-248798392 esv2660478;1:248739517-248797213 esv2421359;1:248753185-248795277 dgv167e212;1:248756742-248797597 1000g;1:248756881-248797809 HI40:ISCA-46576 1:248742276-248742334 gnomAD-SV_v2.1_DEL_1_13893;1:248712455-248757403 HI40:ISCA-46337;1:248729000-248743000 HI40:ISCA-46338;1:248738000-248744000 HI40:ISCA-46340;1:248741000-248749000 gnomAD-SV_v2.1_DEL_1_13892;1:248755656-248758478 HI40:ISCA-46577;1:248755670-248758483 DDD:4648;1:248683401-248814080 esv2763780;1:248693963-248856466 DDD:4636;1:248731000-248798200 HI40:ISCA-46339;1:248737436-248818471 dgv630n100;1:248739502-248798200 DDD:4645;1:248749183-248797201 dgv633n100;1:248753986-248795457 nsv514048;1:248756742-248797597 esv3589559 864662 loss 0.305 0.330 1:248692097-248751707 92.08 0.553342166544692 -0.565086620797697 9 6.5559e-04 1.5575e-04 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 -1_248738899_248785562_DEL_1 1 248738899 248785562 -46663 DEL Benign NA split q44 OR2T10 NM_001004693 248756130 248757069 939 939 100 no 1 txStart-txEnd 5'UTR-3'UTR 248756130 248757069 1000g;DDD:4636;DDD:4639;DDD:4645;DDD:4648;HI40:ISCA-46337;HI40:ISCA-46339;HI40:ISCA-46577;dgv166e212;dgv167e212;dgv630n100;dgv633n100;esv2421359;esv2660478;esv2760083;esv2763780;esv3589558;gnomAD-SV_v2.1_DEL_1_13885;gnomAD-SV_v2.1_DEL_1_13889;nsv514048 1:248712455-248757403;1:248712455-248757403;1:248755656-248758478;1:248755656-248758478;1:248755656-248758478;1:248755670-248758483;1:248605753-248818483;1:248683401-248814080;1:248688222-248828223;1:248693963-248856466;1:248727631-248859425;1:248731000-248798200;1:248731000-248798200;1:248737436-248818471;1:248739346-248798392;1:248739502-248798200;1:248739517-248797213;1:248749183-248797201;1:248753185-248795277;1:248753986-248795457 0.3139 92.08 0.553342166544692 -0.565086620797697 9 6.5559e-04 1.5575e-04 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA full q11.22 AGAP9;ANTXRLP1;ANXA8;BMS1P2;BMS1P2-AGAP9;CTSLP2;FAM25C;FAM25G;GPRIN2;HNRNPA1P33;LINC00842;NPY4R;NPY4R2;SHLD2P3 14 dbVar:nssv15171419;dbVar:nssv15161644;dbVar:nssv15171420;dbVar:nssv15161671;dbVar:nssv15161670;nssv15161864;dbVar:nssv15148987;dbVar:nssv15146649;dbVar:nssv15148014;dbVar:nssv15147999;dbVar:nssv15127252;dbVar:nssv15149138;dbVar:nssv15160810;dbVar:nssv15153822;dbVar:nssv15157044;dbVar:nssv15774462 10:73233-135524321;10:93298-135378918;10:98088-135477883;10:100027-50961640;10:100028-135427143;10:42607636-69160433;10:42890650-52636819;10:43180755-75475666;10:43379743-54025077;10:43957497-55681185;10:46242058-51595050;10:46591858-51028871;10:46966534-51822386;10:47049548-51903662;10:47148814-51626260 0.45;0.45;0.45;1.21;0.45;2.32;6.31;1.90;5.78;5.24;11.49;13.86;12.66;11.15;9.88 dbVar:nssv15148974;dbVar:nssv15147055;dbVar:nssv15147325;dbVar:nssv15149769;dbVar:nssv15153824;dbVar:nssv15775323;dbVar:nssv15152293;dbVar:nssv15147381;dbVar:nssv15149118;dbVar:nssv15148000;dbVar:nssv15148874;dbVar:nssv15605856;dbVar:nssv16252224;dbVar:nssv15153821;dbVar:nssv15155360;dbVar:nssv15153823;nssv15775280;dbVar:nssv15149894;dbVar:nssv15151095;dbVar:nssv15150620;dbVar:nssv16596271;dbVar:nssv16254627 10:46205691-51330432;10:46205691-51911085;10:46205697-51724915;10:46224447-51594991;10:46225365-51874356;10:46235358-51874163;10:46287822-51861565;10:46476966-51724915;10:46491170-51081560;10:46491170-51594991;10:46491170-51664079;10:46544811-51743471;10:46964974-51826226;10:46966534-51700837;10:46966534-51874356;10:46966534-51903755;10:46966534-51903756;10:46966535-51822386;10:46966535-51903756;10:46966536-51874356;10:47132306-51627470 12.00;10.78;11.14;11.45;10.88;10.90;11.03;11.72;13.39;12.05;11.89;11.83;12.65;12.99;12.53;12.45;12.45;12.66;12.45;12.53;10.20 DDD:32922;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094 0.0260 10:47383858-47395064 1000g;10:47383858-47395064 dgv119e214;10:47401000-47409000 gnomAD-SV_v2.1_DUP_10_29728;10:47565000-47570000 gnomAD-SV_v2.1_DUP_10_29733;10:46976293-47023561 1000g;10:46976293-47023561 dgv116e214;10:47089973-47150813 1000g;10:47089973-47150813 dgv118e214;10:47150450-47160300 gnomAD-SV_v2.1_DUP_10_29721;10:47394950-47400600 gnomAD-SV_v2.1_DUP_10_29727;10:47530000-47578125 gnomAD-SV_v2.1_DUP_10_29731;10:46923704-47138897 DDD:32934;10:47007971-47086710 1000g;10:47007971-47086710 1000g;10:47531023-47599037 1000g;10:47531764-47597768 TS40:ISCA-46639;10:47539193-47885867 DDD:32970;10:47545737-47759694 DDD:32972;10:46109534-48312291 nsv516485;10:46931463-47389066 DDD:32936;10:46943378-47742094 dgv24e55... 10:47370500-47380000 gnomAD-SV_v2.1_DUP_10_29725;10:47383858-47395064 1000g;10:47389000-47395000 gnomAD-SV_v2.1_DUP_10_29726;10:47424000-47429050 gnomAD-SV_v2.1_DUP_10_29730;10:46976293-47023561 1000g;10:46976293-47023561 1000g;10:47089973-47150813 1000g;10:47089973-47150813 1000g;10:47148500-47181050 gnomAD-SV_v2.1_DUP_10_29720;10:47321000-47396000 gnomAD-SV_v2.1_DUP_10_29724;10:47412000-47429100 gnomAD-SV_v2.1_DUP_10_29729;10:47534700-47555100 gnomAD-SV_v2.1_DUP_10_29732;10:46943378-47136996 dgv22e55;10:47007971-47086710 1000g;10:47007971-47086710 dgv117e214;10:47531023-47599037 dgv120e214;10:47537369-47652803 esv2421526;10:47543323-47703613 dgv85n27;10:47585775-47727500 gnomAD-SV_v2.1_DUP_10_29734;10:46416327-47756284 DDD:32922;10:46931470-47201116 DDD:32937... 10:47036095-47036306 esv2665191;10:47083161-47083233 gnomAD-SV_v2.1_DEL_10_109994;10:47148774-47150391 1000g;10:47139239-47140637 CMRI:2_pbsv.DEL.1095_duplicate2;10:47172000-47177000 gnomAD-SV_v2.1_DEL_10_109998;10:47177700-47182800 gnomAD-SV_v2.1_DEL_10_109999;10:47191200-47201400 gnomAD-SV_v2.1_DEL_10_110000;10:47211300-47216400 gnomAD-SV_v2.1_DEL_10_110001;10:47254075-47260625 gnomAD-SV_v2.1_DEL_10_110004;10:47301450-47315100 gnomAD-SV_v2.1_DEL_10_110006;10:47423172-47423253 CMRI:0_pbsv.DEL.837_duplicate4;10:47533922-47533982 CMRI:0_pbsv.DEL.813_duplicate4;10:47589914-47590160 CMRI:0_pbsv.DEL.816_duplicate3;10:47252000-47271150 gnomAD-SV_v2.1_DEL_10_110003;10:47582000-47654100 gnomAD-SV_v2.1_DEL_10_110010;10:47531023-47599037 1000g;10:47537369-47652803 esv2421526;10:46416327-47756284 DDD:32922;10:46943378-47742094 dgv23e55; 10:47009185-47009299 gnomAD-SV_v2.1_DEL_10_109993;10:47036099-47036305 CMRI:12_pbsv.DEL.951_duplicate2;10:47088385-47088703 gnomAD-SV_v2.1_DEL_10_109995;10:47148774-47150391 esv3623121;10:47172000-47177000 HI40:ISCA-46432;10:47177700-47182800 HI40:ISCA-46433;10:47191200-47201400 HI40:ISCA-46434;10:47211300-47216400 HI40:ISCA-46435;10:47241600-47251000 gnomAD-SV_v2.1_DEL_10_110002;10:47275450-47281000 gnomAD-SV_v2.1_DEL_10_110005;10:47326200-47331300 gnomAD-SV_v2.1_DEL_10_110008;10:47533873-47534067 CMRI:46_pbsv.DEL.1058_duplicate4;10:47589586-47589851 CMRI:8_pbsv.DEL.1036_duplicate6;10:47589918-47590240 CMRI:3_pbsv.DEL.1200_duplicate5;10:47531450-47579000 gnomAD-SV_v2.1_DEL_10_110009;10:47315750-47326925 gnomAD-SV_v2.1_DEL_10_110007;10:47531023-47599037 esv3623125;10:46109534-48312291 nsv516485;10:46931470-47201116 DDD:32937;10:47150446-47326492 esv2663732 1006588;1013972;1014290;1014377;1016187;1019156;1019393;1021179;1021180;1066321;1066604;1114697;1119287;1120842;1135949;1149039;1226524;1265945;1294933;1324613;1400295;1407950;1430875;1510081;1548870;1626166;1633424;1642745;166480;1668799;1796413;1891434;1907;1909020;1955414;1965390;1970979;1979007;2006405;2041192;2047077;2067479;2067484;2077786;2101919;2127723;2246632;2261385;2271303;2312178;2332155;... gain;loss 0.415 0.500 10:46976181-46976437 LTR78 10:47590101-47594293;10:47590101-47594293 91.07 -2.98697085794417 -2.90416172871297 8 8.8745e-02 2.9629e-04 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2L (ANTXRLP1, +0.00);3A (14 genes, +0.00);5F (+0.00) 1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 AGAP9 NM_001190810 47191843 47213626 21783 1977 100 no 8 txStart-txEnd 5'UTR-3'UTR 47191843 47213626 DDD:32922;DDD:32936;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:47150446-47326492 0.0400 88.1 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 ANTXRLP1 NR_103827 47590260 47640844 735 0 0 no 5 intron4-txEnd UTR 53 3' 47590260 47590995 1000g;DDD:32922;DDD:32970;DDD:32972;TS40:ISCA-46639;dgv120e214;dgv221e212;dgv24e55;dgv85n27;esv2421526;gnomAD-SV_v2.1_DUP_10_29734;nsv516485 10:47531023-47599037;10:47531023-47599037;10:47531764-47597768;10:47537369-47652803;10:47539193-47885867;10:47543323-47703613;10:47545737-47759694;10:47585775-47727500;10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:46966535-48298893 0.1100 1000g;DDD:32922;dgv23e55;esv2421526;esv3623125;gnomAD-SV_v2.1_DEL_10_110010;nsv516485 10:47582000-47654100;10:47531023-47599037;10:47531023-47599037;10:47537369-47652803;10:46109534-48312291;10:46416327-47756284;10:46943378-47742094 0.0318 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 ANXA8 NM_001271702 47157983 47174143 16160 1098 100 no 12 txStart-txEnd 5'UTR-3'UTR 47157983 47174143 DDD:32922;DDD:32936;DDD:32937;dgv221e212;dgv24e55;gnomAD-SV_v2.1_DUP_10_29720;nsv516485 10:47148500-47181050;10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;DDD:32937;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094;10:47150446-47326492 0.0400 76.24 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 BMS1P2 NR_024495 47225570 47243511 17941 0 0 no 9 txStart-txEnd UTR 47225570 47243511 DDD:32922;DDD:32936;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:47150446-47326492 0.0400 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 BMS1P2-AGAP9 NR_160414 47191742 47243488 51746 0 0 no 16 txStart-txEnd UTR 47191742 47243488 DDD:32922;DDD:32936;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:47150446-47326492 0.0400 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 CTSLP2 NR_033407 47270680 47273431 2751 0 0 no 4 txStart-txEnd UTR 47270680 47273431 DDD:32922;DDD:32936;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:47150446-47326492 0.0400 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 FAM25C NM_001137548 47177203 47181688 4485 270 100 no 3 txStart-txEnd 5'UTR-3'UTR 47177203 47181688 DDD:32922;DDD:32936;DDD:32937;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;DDD:32937;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094;10:47150446-47326492 0.0400 91.07 9 8.8745e-02 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 FAM25G NM_001137549 47177220 47181688 4468 270 100 no 3 txStart-txEnd 5'UTR-3'UTR 47177220 47181688 DDD:32922;DDD:32936;DDD:32937;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;DDD:32937;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094;10:47150446-47326492 0.0400 90.79 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 GPRIN2 NM_001385287 46992020 47007881 15861 1449 100 no 4 txStart-txEnd 5'UTR-3'UTR 46992020 47007881 1000g;DDD:32922;DDD:32934;DDD:32936;DDD:32937;dgv116e214;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:46976293-47023561;10:46976293-47023561;10:46976293-47023561;10:46976293-47023561;10:46923704-47138897;10:46943378-47136996;10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.9544 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 82.54 -3.10473776124822 -3.32991530871711 8 3.8557e-06 2.9629e-04 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 HNRNPA1P33 NR_003277 47133294 47133836 542 0 0 no 1 txStart-txEnd UTR 47133294 47133836 1000g;DDD:32922;DDD:32934;DDD:32936;DDD:32937;dgv118e214;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:47089973-47150813;10:47089973-47150813;10:47089973-47150813;10:47089973-47150813;10:46923704-47138897;10:46943378-47136996;10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.9544 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 LINC00842 NR_033957 47096453 47151400 54947 0 0 no 4 txStart-txEnd UTR 47096453 47151400 DDD:32922;DDD:32936;DDD:32937;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 NPY4R NM_005972 47083456 47088320 4864 1128 73 no 3 txStart-txEnd 5'UTR-3'UTR 47083456 47088320 DDD:32922;DDD:32934;DDD:32936;DDD:32937;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:46923704-47138897;10:46943378-47136996;10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 66.73 -2.98697085794417 -2.90416172871297 8 8.2144e-07 6.1160e-09 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 NPY4R2 NM_001278795 47081819 47088173 6354 1128 81 no 2 txStart-txEnd 5'UTR-3'UTR 47081819 47088173 DDD:32922;DDD:32934;DDD:32936;DDD:32937;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:46923704-47138897;10:46943378-47136996;10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 full=1 -10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 SHLD2P3 NR_027634 47379719 47421238 41519 0 0 no 7 txStart-txEnd UTR 47379719 47421238 DDD:32922;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094 0.0260 full=1 -14_22323880_22952279_DEL_1 14 22323880 22952279 -628399 DEL Benign NA full q11.2 LOC105370401 1 CEBPE (morbid/RE=GH_Promoter/Enhancer);CHD8 (HI=3/morbid/RE=GH_Enhancer+GH_Promoter/Enhancer);PABPN1 (morbid/RE=GH_Enhancer+GH_Promoter/Enhancer);SLC7A7 (morbid/RE=EA_enhancer+GH_Enhancer+GH_Promoter/Enhancer);SUPT16H (morbid/RE=GH_Enhancer+GH_Promoter/Enhancer) dbVar:nssv15162475;dbVar:nssv15606090;dbVar:nssv15161908;dbVar:nssv15162476;dbVar:nssv15161629;dbVar:nssv15139565;dbVar:nssv15141262;dbVar:nssv15146564;dbVar:nssv15146758;dbVar:nssv16207193;dbVar:nssv15148269;dbVar:nssv15161107;nssv15161424;dbVar:nssv15161067;dbVar:nssv15132618;dbVar:nssv15134537;dbVar:nssv17955846;dbVar:nssv16091748 14:19000423-107289053;14:19100683-28730087;14:19280734-107287663;14:19327824-107287663;14:19794562-107234280;14:19794562-27768254;14:19794562-34049214;14:20468771-39453619;14:20490853-44562875;14:20511673-44829030;14:20511673-49111245;14:20511674-107285437;14:20619309-107263478;14:20619309-23911404;14:20880747-25487326;14:20925966-23649548;14:21717094-24027220 0.71;6.53;0.71;0.71;0.72;7.88;4.41;3.31;2.61;2.58;2.20;0.72;0.73;19.09;13.64;23.07;27.20 dbVar:nssv15119819;dbVar:nssv15145699;dbVar:nssv16208379;dbVar:nssv17976070 14:20223409-23210490;14:20665105-45754005;14:21143934-23297667;14:21162264-50713602 21.04;2.50;29.18;2.13 TS40:ISCA-37476 14:22111110-23021097 HI40:ISCA-37476 14:22111110-23021097 14:22576718-22576812 CMRI:43_pbsv.INS.DUP.66;14:22420175-22995788 dgv594e212; 14:22576716-22576815 gnomAD-SV_v2.1_DUP_14_37955;14:22111110-23021097 TS40:ISCA-37476;14:22558879-22977816 dgv598e212 14:22582708-22583756 DDD:42194;14:22582714-22583762 esv3633739;14:22774832-22775364 DDD:42212;14:22774835-22775364 gnomAD-SV_v2.1_DEL_14_140481;14:22842146-22848086 gnomAD-SV_v2.1_DEL_14_140495;14:22881667-22882259 gnomAD-SV_v2.1_DEL_14_140496;14:22893733-22898868 gnomAD-SV_v2.1_DEL_14_140497;14:22506096-22519924 dgv596e212;14:22788966-22798356 gnomAD-SV_v2.1_DEL_14_140484;14:22831737-22840637 gnomAD-SV_v2.1_DEL_14_140488;14:22392783-23004503 gnomAD-SV_v2.1_DEL_14_140459;14:22549070-22959340 DDD:42190;14:22631736-22991020 gnomAD-SV_v2.1_DEL_14_140476;14:22834000-22961500 gnomAD-SV_v2.1_DEL_14_140489;14:22855225-22944309 CMRI:35_pbsv.DEL.81_duplicate5 14:22582707-22583756 gnomAD-SV_v2.1_DEL_14_140471;14:22582708-22583756 esv2663069;14:22599000-22607000 gnomAD-SV_v2.1_DEL_14_140473;14:22774832-22775364 esv2658572;14:22793648-22798247 CMRI:117_pbsv.DEL.79_duplicate9;14:22881666-22882261 esv3633748;14:22881728-22882193 nsv563993;14:22908003-22918104 DDD:42230;14:22740393-22749648 gnomAD-SV_v2.1_DEL_14_140479;14:22831736-22840637 DDD:42221;14:22111110-23021097 HI40:ISCA-37476;14:22434290-22958526 gnomAD-SV_v2.1_DEL_14_140462;14:22558879-22995788 dgv599e212;14:22740309-22923239 esv3633740;14:22837284-22944507 dgv611e212 0.250 0.390 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 -14_22323880_22952279_DEL_1 14 22323880 22952279 -628399 DEL Benign NA split q11.2 LOC105370401 NR_148361 22847807 22951948 104141 0 0 no 5 txStart-txEnd UTR 22847807 22951948 TS40:ISCA-37476;dgv594e212;dgv598e212 14:22111110-23021097;14:22420175-22995788;14:22558879-22977816 0.0200 DDD:42190;HI40:ISCA-37476;dgv599e212;gnomAD-SV_v2.1_DEL_14_140459;gnomAD-SV_v2.1_DEL_14_140462;gnomAD-SV_v2.1_DEL_14_140476;gnomAD-SV_v2.1_DEL_14_140489 14:22111110-23021097;14:22392783-23004503;14:22434290-22958526;14:22549070-22959340;14:22558879-22995788;14:22631736-22991020;14:22834000-22961500 0.1597 full=1 -14_74001652_74022324_DEL_1 14 74001652 74022324 -20672 DEL Benign NA full q24.3 ACOT1;HEATR4 2 COQ6 (morbid/RE=EA_enhancer);ISCA2 (morbid/RE=GH_Enhancer);PSEN1 (morbid/RE=EA_enhancer) dbVar:nssv15162475;dbVar:nssv15161908;dbVar:nssv15162476;dbVar:nssv15161629;dbVar:nssv15161107;nssv15161424;dbVar:nssv15161067;dbVar:nssv17517489;dbVar:nssv15161689 14:19000423-107289053;14:19280734-107287663;14:19327824-107287663;14:19794562-107234280;14:20511674-107285437;14:20619309-107263478;14:54654002-75828024;14:73750742-107285437 0.02;0.02;0.02;0.02;0.02;0.02;0.10;0.06 dbVar:nssv15161064;dbVar:nssv8639619;dbVar:nssv15161370 14:70028817-82441728;14:73152116-77698582;14:73809922-79301402 0.17;0.45;0.38 DDD:43163;dgv655e212;dgv657e212 14:73995762-74031034;14:73998504-74050492;14:74001111-74024031 0.1799 1000g;CMRI:3_pbsv.DEL.1043_duplicate5;DDD:43161;DDD:43163;dgv401e199;dgv654e212;esv2421969;esv3634909 14:73995762-74031034;14:73996446-74025592;14:73997052-74024450;14:73997196-74024603;14:73997196-74024603;14:73998504-74050492;14:73998977-74028117;14:74000313-74028320 0.8135 14:74001655-74004589 DDD:43169;14:73995762-74031034 dgv655e212;14:74001111-74024031 dgv657e212;14:74010621-74023183 DDD:43174;14:74011084-74024007 1000g;14:74020544-74030798 DDD:43176 14:74001655-74002844 DDD:43168;14:74008288-74008463 nsv514748;14:73998504-74050492 DDD:43163;14:74007919-74039902 gnomAD-SV_v2.1_DUP_14_38740;14:74011084-74024007 1000g;14:74011084-74024007 dgv407e214 14:74010064-74012567 nsv514749;14:73996446-74025592 dgv401e199;14:73997196-74024603 1000g;14:73998504-74050492 DDD:43163;14:74001124-74020979 DDD:43165;14:74006839-74031034 dgv661e212;14:74011084-74024007 1000g;14:74019700-74051250 gnomAD-SV_v2.1_DEL_14_143695;14:74000313-74028320 CMRI:3_pbsv.DEL.1043_duplicate5 14:74002704-74003063 nsv514747;14:73995762-74031034 dgv654e212;14:73997052-74024450 DDD:43161;14:73997196-74024603 esv3634909;14:73998977-74028117 esv2421969;14:74006839-74024031 dgv660e212;14:74006971-74038879 esv2672436;14:74011084-74024007 esv3634910;14:74022142-74045835 DDD:43178 1059769;2724245 loss 0.420 0.380 14:74001513-74001649;14:74001714-74002042 FLAM_A;L1ME4a 14:74021756-74022225 L1M1 14:74000099-74020296 85.75 2.96959666946894 4.05533207481267 6 6.4141e-05 3.5999e-02 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (2 genes, +0.00);5F (+0.00) 1 -14_74001652_74022324_DEL_1 14 74001652 74022324 -20672 DEL Benign NA split q24.3 ACOT1 NM_001037161 74003846 74010500 6654 1266 100 no 3 txStart-txEnd 5'UTR-3'UTR 74003846 74010500 DDD:43163;dgv655e212;dgv657e212 14:73995762-74031034;14:73998504-74050492;14:74001111-74024031 0.1799 1000g;CMRI:3_pbsv.DEL.1043_duplicate5;DDD:43161;DDD:43163;DDD:43165;dgv401e199;dgv654e212;esv2421969;esv3634909 14:73995762-74031034;14:73996446-74025592;14:73997052-74024450;14:73997196-74024603;14:73997196-74024603;14:73998504-74050492;14:73998977-74028117;14:74001124-74020979;14:74000313-74028320 0.8135 79.11 2.96959666946894 4.05533207481267 8 6.4141e-05 3.5999e-02 full=1 -14_74001652_74022324_DEL_1 14 74001652 74022324 -20672 DEL Benign NA split q24.3 HEATR4 NM_001220484 73945188 74025651 20673 0 0 no 18 intron1-intron1 5'UTR 3130 5' 74001651 74022324 DDD:43163;dgv655e212;dgv657e212 14:73995762-74031034;14:73998504-74050492;14:74001111-74024031 0.1799 1000g;CMRI:3_pbsv.DEL.1043_duplicate5;DDD:43161;DDD:43163;dgv401e199;dgv654e212;esv2421969;esv3634909 14:73995762-74031034;14:73996446-74025592;14:73997052-74024450;14:73997196-74024603;14:73997196-74024603;14:73998504-74050492;14:73998977-74028117;14:74000313-74028320 0.8135 1059769;2724245 loss 85.75 -0.328810289068687 -0.503765753071617 6 1.3711e-29 6.2323e-17 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA full q11.2-q11.1 CXADRP2;FAM30C;GOLGA6L6;GOLGA8CP;HERC2P3;LINC01193;LINC02203;LOC101927079;LOC102723534;LOC646214;MIR3118-2;MIR3118-3;MIR3118-4;MIR5701-1;MIR5701-2;MIR5701-3;NBEAP1;NF1P2;OR4M2;OR4N4;OR4N4C;POTEB;POTEB2;POTEB3 24 ADAM22 (morbid/RE=mTL_miRNA);CA12 (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);DICER1 (HI=3/morbid/RE=mTL_miRNA);EDAR (morbid/RE=mTL_miRNA);EGLN1 (morbid/RE=mTL_miRNA);ERBB3 (morbid/RE=mTL_miRNA);GABRB2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);HSPD1 (morbid/RE=mTL_miRNA);IL6ST (morbid/RE=mTL_miRNA);INF2 (morbid/RE=mTL_miRNA);ISCU (morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNJ10 (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);LRIG2 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);NDUFS1 (morbid/RE=mTL_miRNA);NPM1 (morbid/RE=mTL_miRNA);PEX26 (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);PRLR (morbid/RE=mTL_miRNA);PURA (HI=3/morbid/RE=mTL_miRNA);RAC3 (morbid/RE=mTL_miRNA);SH2D1A (HI=3/morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SLC7A14 (morbid/RE=mTL_miRNA);SLC7A7 (morbid/RE=mTL_miRNA);SMAD4 (HI=3/morbid/RE=mTL_miRNA);SMAD6 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SMOC2 (morbid/RE=mTL_miRNA);SNAI2 (morbid/RE=mTL_miRNA);SOX17 (morbid/RE=mTL_miRNA);TTC37 (morbid/RE=mTL_miRNA);TULP1 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA);ZNF711 (morbid/RE=mTL_miRNA) dbVar:nssv15172447;dbVar:nssv15149081;dbVar:nssv15148902;dbVar:nssv15125410;dbVar:nssv15127689;dbVar:nssv15127462;dbVar:nssv15126524;dbVar:nssv15124656;dbVar:nssv15127659;dbVar:nssv15126021;dbVar:nssv15172190;dbVar:nssv15150569;dbVar:nssv15147052;dbVar:nssv15145742;dbVar:nssv15147053;dbVar:nssv15175556;dbVar:nssv15145744;dbVar:nssv15774514;dbVar:nssv15148785;dbVar:nssv15605894;dbVar:nssv15149135;dbVar:nssv15148575;dbVar:nssv15147687;dbVar:nssv15605895;dbVar:nssv15147058;dbVar:nssv15145747;dbVar:nssv15146452;dbVar:nssv15149084;dbVar:nssv15147355;dbVar:nssv15149616;dbVar:nssv15147801;dbVar:nssv15146958;dbVar:nssv15149124;dbVar:nssv15123304;dbVar:nssv15147513;dbVar:nssv15127079;dbVar:nssv15605897;dbVar:nssv15605899 15:20016812-102493540;15:20044343-28924405;15:20045835-32914140;15:20063341-102521392;15:20063341-29093456;15:20063341-29209620;15:20063341-30448351;15:20063341-32439302;15:20063341-32942613;15:20063341-32986584;15:20071674-102461162;15:20071674-30737344;15:20085003-28947309;15:20085003-29210720;15:20085004-28178425;15:20102541-29031690;15:20110723-28408897;15:20179528-32998070;15:20190549-28406650;15:20190549-30300265;15:20190549-32386089;15:20190549-32917801;15:20190549-32917857;15:20191653-28525310;15:20207714-30641396;15:20207714-32413623;15:20251769-28631040;15:20306550-26208861;15:20686197-30509384;15:20733396-102511616;15:20733396-28406650;15:20733396-28406709;15:20848461-27662530;15:21129985-28535266;15:22304597-28577787;15:22318645-29209620;15:22382861-32396457;15:22383300-32917689 2.24;20.77;14.34;2.24;20.43;20.17;17.76;14.91;14.32;14.27;2.24;17.30;20.82;20.22;22.79;20.66;22.23;14.39;22.45;18.25;15.13;14.49;14.49;22.14;17.68;15.11;22.02;31.26;17.54;2.05;21.84;21.84;22.91;17.28;1.67;1.32;0.26;0.25 dbVar:nssv16865885;dbVar:nssv15605896;dbVar:nssv15123310;dbVar:nssv16208656;dbVar:nssv16215320;dbVar:nssv15147060 15:20612841-23272733;15:20848751-32925141;15:21129985-32514926;15:21903816-23272733;15:22299435-23226254;15:22318598-28940098 67.54;12.92;11.24;36.93;11.86;1.37 DDD:44001;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019 0.3900 DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.1300 15:20729300-20736525 gnomAD-SV_v2.1_DUP_15_39414;15:20958000-20967125 gnomAD-SV_v2.1_DUP_15_39422;15:21301350-21312400 gnomAD-SV_v2.1_DUP_15_39426;15:21941251-21941251 1000g;15:22336905-22343964 1000g;15:22336905-22343964 1000g;15:22336905-22343964 dgv434e214;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 dgv430e214;15:20731675-20778150 gnomAD-SV_v2.1_DUP_15_39416;15:20749534-20773538 DDD:44053;15:20786000-20827000 gnomAD-SV_v2.1_DUP_15_39420;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20846722-20867075 dgv431e214;15:21040437-21077011 nsv514765;15:21153622-21170901 nsv514766;15:21339000-21351000 gnomAD-SV_v2.1_DUP_15_39427... 15:20717000-20724000 gnomAD-SV_v2.1_DUP_15_39413;15:20746872-20747023 DDD:44052;15:20989050-20994350 gnomAD-SV_v2.1_DUP_15_39424;15:21315923-21318351 CMRI:10_pbsv.SPLIT.DUP.48;15:22170840-22170894 CMRI:5_pbsv.INS.DUP.71_duplicate2;15:22336905-22343964 1000g;15:22336905-22343964 1000g;15:22364338-22364338 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20730500-20754075 gnomAD-SV_v2.1_DUP_15_39415;15:20735000-20745000 gnomAD-SV_v2.1_DUP_15_39417;15:20783000-20799000 gnomAD-SV_v2.1_DUP_15_39419;15:20807000-20821500 gnomAD-SV_v2.1_DUP_15_39421;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20846722-20867075 1000g;15:20935077-20960284 nsv514764;15:21145102-21164300 TS40:ISCA-46688;15:21278000-21312400 gnomAD-SV_v2.1_DUP_15_39425... 15:20587419-20587601 gnomAD-SV_v2.1_DEL_15_145824;15:20587443-20587601 CMRI:2_pbsv.DEL.80_duplicate11;15:20649714-20649821 CMRI:107_pbsv.DEL.47_duplicate8;15:20698000-20706500 gnomAD-SV_v2.1_DEL_15_145825;15:20734328-20735311 CMRI:22_pbsv.DEL.64_duplicate9;15:20739871-20740113 CMRI:15_pbsv.DEL.58_duplicate7;15:20820627-20821162 gnomAD-SV_v2.1_DEL_15_145830;15:20945621-20946011 gnomAD-SV_v2.1_DEL_15_145834;15:21321039-21325126 DDD:44088;15:21317829-21317946 CMRI:73_pbsv.DEL.47_duplicate6;15:21888015-21888112 CMRI:2_pbsv.DEL.94_duplicate7;15:21982344-21982399 CMRI:2_pbsv.DEL.99_duplicate9;15:22137123-22142638 CMRI:31_pbsv.DEL.80_duplicate7;15:22336905-22343964 1000g;15:20729175-20745525 HI40:ISCA-46468;15:20749534-20773538 DDD:44053;15:20806100-20823500 gnomAD-SV_v2.1_DEL_15_145829;15:21042050-21056300 HI40:ISCA-46469;15:21135232-21135378 gnomAD-SV_v2.1_DEL_15_145838;15:21310826-21319227 CMRI:78_pbsv.DEL.46_duplicate5;15:22360686-22387071 DDD:44119... 15:20581464-20589613 esv2674516;15:20580644-20589857 CMRI:0_pbsv.DEL.41_duplicate6;15:20644488-20644611 CMRI:86_pbsv.DEL.61_duplicate4;15:20649904-20649957 CMRI:2_pbsv.DEL.83_duplicate6;15:20732300-20738500 gnomAD-SV_v2.1_DEL_15_145827;15:20739577-20739744 CMRI:4_pbsv.DEL.58_duplicate1;15:20740033-20740106 CMRI:3_pbsv.DEL.63_duplicate3;15:20945597-20946011 esv2664547;15:21247373-21247452 gnomAD-SV_v2.1_DEL_15_145841;15:21317547-21317664 CMRI:122_pbsv.DEL.38_duplicate9;15:21888050-21888102 gnomAD-SV_v2.1_DEL_15_145844;15:21888019-21888068 CMRI:2_pbsv.DEL.95_duplicate9;15:22096000-22101000 gnomAD-SV_v2.1_DEL_15_145846;15:22336854-22344093 esv2662884;15:22336905-22343964 esv3635758;15:20729175-20745525 gnomAD-SV_v2.1_DEL_15_145826;15:20781000-20811000 gnomAD-SV_v2.1_DEL_15_145828;15:20976350-20994050 gnomAD-SV_v2.1_DEL_15_145835;15:21042050-21056300 gnomAD-SV_v2.1_DEL_15_145837;15:21282800-21314300 gnomAD-SV_v2.1_DEL_15_145842;15:21904679-21949433 DDD:44097... 1015796;1015797;1015798;1015998;1015999;1016000;1016239;1016240;1016241;1016617;1016982;1017230;1017232;1018200;1018423;1018674;1019697;1041478;1088979;1102049;1206046;1431375;1476626;1492739;1519832;1780422;1902540;1928496;1988493;2008364;2156400;2158189;2365897;2520305;2574919;601849;602060;602746;603901;603902;604540;604541;604788;605025;605205;605206;605477;605817;606172;606296;606559;... gain;loss 0.310 0.275 15:20564282-20581643 15:22292726-22423285 15:20200401-22365100 High Signal Region 15:22387401-22749100 Low Mappability 93.81 2.22375841006203 2.58284576037233 8 3.5277e-01 5.7189e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (24 genes, +0.00);5F (+0.00) 1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 CXADRP2 NR_024387 22014420 22016878 2458 0 0 no 1 txStart-txEnd UTR 22014420 22016878 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 FAM30C NR_145444 21208605 21255165 46560 0 0 no 4 txStart-txEnd UTR 21208605 21255165 DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55;esv3892595 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 GOLGA6L6 NM_001145004 20737093 20747114 10021 2171 100 yes 12 txStart-txEnd 5'UTR-3'UTR 20737093 20747114 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;gnomAD-SV_v2.1_DUP_15_39415;gnomAD-SV_v2.1_DUP_15_39416 15:20730500-20754075;15:20731675-20778150;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 93.81 0.630577750419089 0.0606178603183018 8 2.2875e-19 8.6864e-02 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 GOLGA8CP NR_027411 20767673 20781026 13353 0 0 no 18 txStart-txEnd UTR 20767673 20781026 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2-q11.1 HERC2P3 NR_036432 20613649 20711433 97784 0 0 no 26 txStart-txEnd UTR 20613649 20711433 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LINC01193 NR_040094 21145766 21198633 52867 0 0 no 5 txStart-txEnd UTR 21145766 21198633 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LINC02203 NR_015416 22278009 22371088 93079 0 0 no 11 txStart-txEnd UTR 22278009 22371088 DDD:44001;DDD:44096;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55 15:22267463-22591752;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LOC101927079 NR_110480 22278030 22383564 105534 0 0 no 9 txStart-txEnd UTR 22278030 22383564 DDD:44001;DDD:44096;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55 15:22267463-22591752;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 661973;664511;665411;669653;681562;688758;690131;701704;718266;747790 loss full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LOC102723534 NR_160687 20711668 20727150 15482 0 0 no 5 txStart-txEnd UTR 20711668 20727150 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;gnomAD-SV_v2.1_DUP_15_39412 15:20706000-20747000;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LOC646214 NR_027053 21932513 21940739 8226 0 0 no 1 txStart-txEnd UTR 21932513 21940739 DDD:44001;DDD:44096;DDD:44097;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:21904679-21949433;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44097;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:21904679-21949433;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR3118-2 NR_036062 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR3118-3 NR_036063 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR3118-4 NR_036134 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR5701-1 NR_049886 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21145102-21164300;15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR5701-2 NR_049895 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21145102-21164300;15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR5701-3 NR_128721 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:21145102-21164300;15:21069662-21311925;15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:21069662-21311925;15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 NBEAP1 NR_027992 20874796 20961480 86684 0 0 no 3 txStart-txEnd UTR 20874796 20961480 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 NF1P2 NR_028506 22133180 22145802 12622 0 0 no 8 txStart-txEnd UTR 22133180 22145802 DDD:44001;DDD:44096;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 OR4M2 NM_001004719 22368477 22369561 1084 942 95 no 1 txStart-txEnd 5'UTR-3'UTR 22368477 22369561 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dgv2191n100;dgv3e224;dgv40e203;dgv435e214;dgv92e55;dgv93e55;nsv514767 15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22360686-22387071;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22360686-22387071;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 76.23 9 3.9447e-08 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 OR4N4 NM_001005241 22382381 22383815 1434 951 70 no 1 txStart-txEnd 5'UTR-3'UTR 22382381 22383815 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:22360686-22387071;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22360686-22387071;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 75.33 -0.271906921498889 -0.565772314050669 9 5.1332e-05 1.8051e-02 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 OR4N4C NM_001365389 22369147 22383572 14425 1002 100 no 2 txStart-txEnd 5'UTR-3'UTR 22369147 22383572 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:22360686-22387071;15:22267463-22591752;15:22278200-22574827;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:22360686-22387071;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 664511;688758;701704;718266;747790 loss full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 POTEB NM_001277304 22051852 22083259 31407 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22051852 22083259 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 91.86 9 3.5277e-01 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 POTEB2 NM_001277303 22051852 22082803 30951 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22051852 22082803 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 92.58 2.22375841006203 2.58284576037233 8 4.2457e-02 5.7189e-01 full=1 -15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 POTEB3 NM_207355 22048289 22083259 34970 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22048289 22083259 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 full=1 -15_34735950_34806953_DEL_1 15 34735950 34806953 -71003 DEL Benign NA full q14 0 NOP10 (morbid/RE=EA_enhancer);SLC12A6 (morbid/RE=EA_enhancer) dbVar:nssv15172447;dbVar:nssv15125410;dbVar:nssv15172190;dbVar:nssv15149616;dbVar:nssv15147411;dbVar:nssv15150618;nssv15150717;dbVar:nssv15151655;dbVar:nssv15145681 15:20016812-102493540;15:20063341-102521392;15:20071674-102461162;15:20733396-102511616;15:22765629-38837526;15:22770423-102429112;15:31115048-102354857;15:32899500-35492630 0.09;0.09;0.09;0.09;0.44;0.09;0.10;2.74 dbVar:nssv15147319;dbVar:nssv16208403;dbVar:nssv15127755;dbVar:nssv15148236;dbVar:nssv15127602;dbVar:nssv16208407;dbVar:nssv15154730;dbVar:nssv15146365;dbVar:nssv15146268;dbVar:nssv16208948 15:22698523-38381783;15:22770422-36861479;15:23622527-102521392;15:25279017-37496505;15:29209621-102521392;15:31675453-35689958;15:32446830-34868996;15:32618338-39686269;15:32928005-40526026;15:34197489-38656254 0.45;0.50;0.09;0.58;0.10;1.77;2.93;1.00;0.93;1.59 1000g 15:34721237-34836826 0.0144 1000g;DDD:44673;DDD:44674;HI40:ISCA-46481;HI40:ISCA-46482;dgv2562n100;dgv313n27;dgv43e203;esv3636115;esv3892663;gnomAD-SV_v2.1_DEL_15_146738;gnomAD-SV_v2.1_DEL_15_146739;nsv517751 15:34647569-34871296;15:34674031-35008201;15:34674425-35009836;15:34678778-34862723;15:34710127-34856557;15:34710127-34856557;15:34714112-34830932;15:34718595-34807869;15:34718595-34871296;15:34721237-34836826;15:34721237-34836826;15:34726358-34872885;15:34726358-34872885 0.1680 15:34764551-34764551 1000g; 15:34741740-34742019 1000g;15:34721237-34836826 1000g 15:34741749-34742029 esv2678102;15:34743793-34743843 gnomAD-SV_v2.1_DEL_15_146742;15:34741744-34742023 CMRI:0_pbsv.DEL.228_duplicate7;15:34802473-34810922 1000g;15:34802548-34810836 DDD:44684;15:34802548-34810836 CMRI:59_pbsv.DEL.218_duplicate9;15:34779302-34783300 DDD:44682;15:34674031-35008201 DDD:44673;15:34678778-34862723 dgv43e203;15:34710127-34856557 gnomAD-SV_v2.1_DEL_15_146738;15:34718595-34800595 dgv312n27;15:34718595-34871296 dgv313n27;15:34721237-34836826 esv3636115;15:34726358-34872885 gnomAD-SV_v2.1_DEL_15_146739 15:34741740-34742019 1000g;15:34741752-34742021 gnomAD-SV_v2.1_DEL_15_146741;15:34746988-34747300 gnomAD-SV_v2.1_DEL_15_146743;15:34746975-34747300 CMRI:0_pbsv.DEL.230_duplicate6;15:34802473-34810922 esv3636118;15:34802595-34810858 gnomAD-SV_v2.1_DEL_15_146744;15:34779146-34783492 esv2667455;15:34647569-34871296 nsv517751;15:34674425-35009836 DDD:44674;15:34710127-34856557 HI40:ISCA-46481;15:34714112-34830932 dgv2562n100;15:34718595-34807869 esv3892663;15:34721237-34836826 1000g;15:34726358-34872885 HI40:ISCA-46482 1026888;1027127;10752;1091757;1285545;1305919;1410197;1489091;1675608;175022;177092;177093;1876389;1880863;1960483;1963174;1977713;2258547;2316987;2561157;29065;298049;335699;358334;377509;379876;399343;456471;494211;659804;718453;778754;998882 gain;loss 0.340 0.660 15:34730084-34776964 15:34782963-34820866;15:34800001-34813836 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (0 gene, +0.00);5F (+0.00) 1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA full p11.2 LOC102723655;LOC105369266;LOC390705;SLC6A10P;TP53TG3;TP53TG3B;TP53TG3C;TP53TG3E;TP53TG3F 9 dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv16216874;dbVar:nssv15126545;dbVar:nssv15133058;dbVar:nssv15126469 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:5805002-34230001;16:24381954-33923059;16:30703234-35147508;16:31986099-90294753 1.13;1.13;1.13;1.13;1.13;3.57;10.65;22.86;1.74 dbVar:nssv15141243 16:28826163-34375007 18.31 DDD:47058;DDD:47062;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.0700 DDD:47058;DDD:47062;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.0715 16:32486529-32486871 DDD:47082;16:32740800-32750700 gnomAD-SV_v2.1_DUP_16_42037;16:32900256-32908555 nsv514802;16:33237167-33240395 CMRI:0_pbsv.SPLIT.DUP.569;16:33237168-33239696 CMRI:36_pbsv.SPLIT.DUP.817;16:33237169-33241215 CMRI:25_pbsv.SPLIT.DUP.690;16:33406670-33406761 CMRI:3_pbsv.INS.DUP.833_duplicate1;16:32663000-32707000 gnomAD-SV_v2.1_DUP_16_42033;16:32684868-32688916 DDD:47098;16:32748500-32754000 gnomAD-SV_v2.1_DUP_16_42038;16:32831660-32863935 1000g;16:32831660-32863935 dgv508e214;16:32903492-32927819 dgv509e214;16:33242400-33262000 gnomAD-SV_v2.1_DUP_16_42043;16:33446164-33480261 1000g;16:33446164-33480261 dgv510e214;16:33470756-33495606 1000g;16:33470756-33495606 dgv511e214;16:33484522-33543753 1000g;16:32589803-32684945 DDD:47091;16:32611030-32642738 1000g... 16:32473116-32486576 DDD:47080;16:32593538-32593538 1000g;16:32772000-32777000 gnomAD-SV_v2.1_DUP_16_42039;16:33231300-33237300 gnomAD-SV_v2.1_DUP_16_42041;16:33237168-33239048 CMRI:24_pbsv.SPLIT.DUP.761;16:33237168-33240638 CMRI:2_pbsv.SPLIT.DUP.788;16:33237859-33241258 CMRI:6_pbsv.SPLIT.DUP.921;16:33467710-33467710 1000g;16:32664500-32696000 gnomAD-SV_v2.1_DUP_16_42034;16:32708700-32724200 gnomAD-SV_v2.1_DUP_16_42035;16:32831660-32863935 1000g;16:32831660-32863935 1000g;16:32903492-32927819 1000g;16:33211000-33230000 gnomAD-SV_v2.1_DUP_16_42040;16:33253000-33262000 gnomAD-SV_v2.1_DUP_16_42044;16:33446164-33480261 1000g;16:33464249-33499453 DDD:47125;16:33470756-33495606 1000g;16:33484522-33543753 1000g;16:33484522-33543753 dgv512e214;16:32611030-32642738 1000g... 16:32513047-32514413 CMRI:14_pbsv.DEL.714_duplicate7;16:32523772-32525827 CMRI:77_pbsv.DEL.783_duplicate11;16:32588181-32590788 esv3638433;16:32598582-32602963 esv3638436;16:32600306-32601869 esv3638437;16:32823142-32823276 CMRI:32_pbsv.DEL.766_duplicate11;16:32913496-32913558 CMRI:42_pbsv.DEL.503_duplicate7;16:33053570-33055362 CMRI:32_pbsv.DEL.767_duplicate8;16:33070335-33070437 CMRI:0_pbsv.DEL.568_duplicate8;16:33238346-33238403 CMRI:7_pbsv.DEL.745_duplicate8;16:33405371-33405435 CMRI:6_pbsv.DEL.927_duplicate10;16:33433594-33433957 gnomAD-SV_v2.1_DEL_16_153879;16:33462282-33462339 gnomAD-SV_v2.1_DEL_16_153880;16:32831660-32863935 1000g;16:32903492-32927819 esv3638449;16:33486471-33490892 DDD:47128;16:32511180-32878155 dgv819e212;16:32589803-32684945 DDD:47091;16:32629631-32641916 1000g;16:32656000-32802000 HI40:ISCA-46492;16:33204449-33378738 DDD:47113... 16:32486808-32486871 DDD:47084;16:32520009-32520694 CMRI:59_pbsv.DEL.501_duplicate7;16:32588181-32590788 1000g;16:32598582-32602963 1000g;16:32600306-32601869 1000g;16:32658500-32665500 gnomAD-SV_v2.1_DEL_16_153862;16:32854307-32854394 gnomAD-SV_v2.1_DEL_16_153866;16:33025349-33025404 CMRI:18_pbsv.DEL.717_duplicate7;16:33070282-33070437 CMRI:0_pbsv.DEL.567_duplicate7;16:33237308-33237424 CMRI:16_pbsv.DEL.487_duplicate8;16:33240635-33240708 CMRI:150_pbsv.DEL.581_duplicate6;16:33417667-33419043 CMRI:88_pbsv.DEL.792_duplicate7;16:33429085-33429134 CMRI:3_pbsv.DEL.834_duplicate5;16:32684868-32688916 DDD:47098;16:32903492-32927819 1000g;16:33464249-33499453 DDD:47125;16:32052946-32496748 DDD:47057;16:32541493-32648861 DDD:47087;16:32590685-32653097 DDD:47092;16:32629631-32641916 esv3638442;16:32656000-32802000 gnomAD-SV_v2.1_DEL_16_153860... 1014522;1015016;1015393;1018209;1018436;1018684;1019197;1019701;1019937;1020690;1020691;1020963;1022158;1022926;1022927;1023636;1024072;1024694;1024914;1026893;1026894;1027135;1234678;1672230;1673113;1952301;2086322;2125149;2295606;3055141;3111299;601855;602757;604309;605486;606982;608009;608950;608951;609265;646528;646529;647521;647804;647805;648719;650450;650740;650929;651557;652481;... gain;loss 0.255 0.275 16:32471562-32471589 AT_rich 16:32328196-32493021;16:32333061-32489849;16:32333061-32492391;16:32462184-32472474 16:33363548-33517471;16:33465320-33517471;16:33466597-33509202 94.39 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (9 genes, +0.00);5F (+0.00) 1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 LOC102723655 NM_001368237 32684839 32687448 2609 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684839 32687448 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 LOC105369266 NR_158162 33215160 33231582 16422 0 0 no 5 txStart-txEnd UTR 33215160 33231582 DDD:47058;DDD:47062;DDD:47113;dgv50e203;dgv821e212 16:33204449-33378738;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.0700 DDD:47058;DDD:47062;DDD:47113;dgv50e203 16:33204449-33378738;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.0715 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 LOC390705 NR_033866 33298267 33298702 435 0 0 no 1 txStart-txEnd UTR 33298267 33298702 DDD:47058;DDD:47062;DDD:47113;DDD:47114;DDD:47116;dgv50e203;dgv821e212 16:33204449-33378738;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324;16:33230271-33739925;16:33270420-33827235 0.5150 DDD:47058;DDD:47062;DDD:47113;DDD:47114;dgv50e203 16:33204449-33378738;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33230271-33739925 0.1243 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 SLC6A10P NR_003083 32888796 32896463 7667 0 0 no 9 txStart-txEnd UTR 32888796 32896463 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212 16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1314 DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:32129166-32904510;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.1692 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3 NM_016212 32684848 32687450 2602 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684848 32687450 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 94.39 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3B NM_001099687 32684848 32687450 2602 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684848 32687450 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 92.24 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3C NM_001205259 32685408 32687448 2040 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32685408 32687448 DDD:47058;DDD:47062;DDD:47063;DDD:47098;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32684868-32688916;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;DDD:47098;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32684868-32688916;16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 91.96 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3E NM_001330061 32684844 32687431 2587 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684844 32687431 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=1 -16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3F NM_001330066 32684848 32687430 2582 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684848 32687430 DDD:47058;DDD:47062;DDD:47063;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:32663000-32707000;16:32664500-32696000;16:32659200-32810000;16:32129166-32904510;16:32257510-32714406;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324 0.1415 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dgv50e203;dgv819e212;esv2421440;gnomAD-SV_v2.1_DEL_16_153860 16:32511180-32878155;16:32656000-32802000;16:32656000-32802000;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.2300 full=1 -16_34493207_34702366_DUP_1 16 34493207 34702366 209159 DUP Benign NA full p11.2-p11.1 LINC01566 1 dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv15133058;dbVar:nssv15126469;dbVar:nssv15150356 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:30703234-35147508;16:31986099-90294753;16:34197493-64509054 0.23;0.23;0.23;0.23;0.23;4.71;0.36;0.69 1000g;DDD:47173;DDD:47179;TS40:ISCA-37481;dgv117e55;dgv2962n100;dgv51e203;dgv824e212;esv2421698;esv3638500;gnomAD-SV_v2.1_DUP_16_42078;nsv514804;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531;16:34441796-34784591;16:34445084-34774280;16:34456525-34736855;16:34457086-34712399;16:34457086-34712399;16:34465000-34757000;16:34470705-34757071;16:34471852-34731191;16:34476781-34747070 0.1875 HI40:ISCA-37481 16:34202089-35147508 16:34202089-35147508 TS40:ISCA-37481;16:34410570-34796531 dgv117e55;16:34445084-34774280 dgv824e212;16:34457086-34712399 1000g;16:34465000-34757000 gnomAD-SV_v2.1_DUP_16_42078;16:34471852-34731191 nsv514804;16:34567146-34656231 DDD:47183;16:34595000-34606750 gnomAD-SV_v2.1_DUP_16_42082 16:34197352-35283226 dgv51e203;16:34259806-34805859 nsv516385;16:34441796-34784591 dgv2962n100;16:34456525-34736855 DDD:47173;16:34457086-34712399 esv3638500;16:34470705-34757071 esv2421698;16:34476781-34747070 DDD:47179;16:34572795-34661165 gnomAD-SV_v2.1_DUP_16_42081 16:34568138-34568693 gnomAD-SV_v2.1_DEL_16_153949;16:34202089-35147508 HI40:ISCA-37481 16:34539693-34540322 DDD:47181;16:34568384-34568693 CMRI:3_pbsv.DEL.864_duplicate7 0.385 0.335 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);3A (1 gene, +0.00);5F (+0.00) 1 -16_34493207_34702366_DUP_1 16 34493207 34702366 209159 DUP Benign NA split p11.2-p11.1 LINC01566 NR_027080 34597786 34626084 28298 0 0 no 7 txStart-txEnd UTR 34597786 34626084 1000g;DDD:47173;DDD:47179;DDD:47183;TS40:ISCA-37481;dgv117e55;dgv2962n100;dgv51e203;dgv824e212;esv2421698;esv3638500;gnomAD-SV_v2.1_DUP_16_42078;gnomAD-SV_v2.1_DUP_16_42081;nsv514804;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531;16:34441796-34784591;16:34445084-34774280;16:34456525-34736855;16:34457086-34712399;16:34457086-34712399;16:34465000-34757000;16:34470705-34757071;16:34471852-34731191;16:34476781-34747070;16:34567146-34656231;16:34572795-34661165 0.1875 HI40:ISCA-37481 16:34202089-35147508 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA full q12 CCL3L1;CCL3L3;CCL4L1;CCL4L2;TBC1D3B;TBC1D3F;TBC1D3G;TBC1D3H;TBC1D3L 9 PEX12 (morbid/RE=GH_Enhancer);PIGW (morbid/RE=EA_enhancer);ZNHIT3 (morbid/RE=GH_Enhancer) 17q12 recurrent (RCAD syndrome) region (includes HNF1B) dbVar:nssv15149908;nssv15152170;dbVar:nssv15159024;dbVar:nssv15160732;dbVar:nssv15159027;dbVar:nssv15127236;dbVar:nssv15775117;dbVar:nssv15132421;dbVar:nssv15132422;dbVar:nssv15155541;dbVar:nssv15155542;dbVar:nssv15605916;dbVar:nssv16736632;dbVar:nssv15138685;dbVar:nssv15142873;dbVar:nssv15141421;dbVar:nssv15132229;nssv15139703;dbVar:nssv15125411;dbVar:nssv15125622;dbVar:nssv15130152;nssv15132345;nssv15139691;dbVar:nssv15135915;dbVar:nssv15124805;TS3:ISCA-37432;dbVar:nssv15132164;dbVar:nssv17649867;dbVar:nssv16215252;dbVar:nssv15123756;dbVar:nssv15133519;dbVar:nssv16736603;dbVar:nssv15135870 17:527-81041938;17:7215-81058310;17:8548-81060040;17:12345-81057996;17:16757564-81048189;17:21690654-38772647;17:34310999-36297053;17:34360169-36209228;17:34425363-36283612;17:34426245-36225988;17:34437476-36214026;17:34437476-36243028;17:34437483-36244358;17:34437483-36350584;17:34437483-36404555;17:34508118-36248918;17:34526602-36188734;17:34604365-36231917;17:34611353-36248918;17:34611353-36263019;17:34750819-36354738;17:34815073-36192489;17:34815185-36209228;17:34815467-36249366;17:34815552-36244358;17:34815552-36249800;17:34817423-36173763;17:34817423-36243028;17:34817423-36248918 0.47;0.47;0.47;0.47;0.59;2.22;19.13;20.55;20.45;21.11;21.39;21.05;21.03;19.86;19.32;17.77;17.50;13.09;12.59;12.48;4.16;0.17;0.16;0.14;0.14;0.13;0.00;0.00;0.00 17q12 recurrent (RCAD syndrome) region (includes HNF1B) dbVar:nssv15137372;dbVar:nssv8639331;dbVar:nssv15142228;dbVar:nssv15133035;dbVar:nssv15142015;dbVar:nssv15153182;dbVar:nssv15153183;dbVar:nssv15133261;dbVar:nssv15124226;dbVar:nssv15132100;nssv15139544;dbVar:nssv15127168;dbVar:nssv15133024;dbVar:nssv17955818;HI3:ISCA-37432;dbVar:nssv15149164;dbVar:nssv15129143;dbVar:nssv15130784;nssv15172799;dbVar:nssv15173493;dbVar:nssv15131818;dbVar:nssv15135737;dbVar:nssv15135591;dbVar:nssv15134619 17:34360169-36248859;17:34360228-36473024;17:34447114-36283612;17:34450406-36248918;17:34475680-36283612;17:34475680-36311009;17:34477386-36404555;17:34508118-36173763;17:34604365-36188734;17:34611353-36248918;17:34750819-81048189;17:34768967-36263019;17:34807070-36284994;17:34815073-36192489;17:34815073-36192492;17:34815552-36208392;17:34815552-36244358;17:34815552-36307189;17:34817423-36168104;17:34817423-36188700;17:34817423-36248918;17:34817423-36263019 20.12;17.99;20.17;20.41;18.91;18.62;17.65;18.57;13.45;12.59;0.14;3.25;0.70;0.17;0.17;0.14;0.14;0.13;0.00;0.00;0.00;0.00 dgv122e55 17:34426246-34870708 0.0300 17:34558278-34558410 CMRI:61_pbsv.INS.DUP.608_duplicate1;17:34804250-34815000 gnomAD-SV_v2.1_DUP_17_43955;17:34502930-34524195 nsv514837;17:34517741-34540630 DDD:49256;17:34495255-34583253 CMRI:213_pbsv.SPLIT.DUP.926;17:34610042-34641487 nsv514839;17:34750173-34796456 DDD:49284;17:34424712-34477480 dgv908e212;17:34431132-34484342 DDD:49235;17:34436100-34482872 1000g;17:34436100-34482872 dgv572e214;17:34437483-34477480 dgv910e212;17:34436811-34514716 CMRI:12_pbsv.SPLIT.DUP.661;17:34387632-34629696 esv2762388;17:34426246-34870708 dgv122e55;17:34435674-34621060 DDD:49237; 17:34538648-34540293 nsv514838;17:34746065-34746521 DDD:49283;17:34805000-34811400 gnomAD-SV_v2.1_DUP_17_43956;17:34502941-34524192 TS40:ISCA-46706;17:34580927-34587273 DDD:49263;17:34509789-34523335 CMRI:6_pbsv.SPLIT.DUP.969;17:34625755-34641426 DDD:49271;17:34416412-34496071 nsv514836;17:34425364-34477387 dgv121e55;17:34435513-34485079 dgv3148n100;17:34436100-34482872 1000g;17:34437129-34485091 esv2421587;17:34443777-34537005 DDD:49243;17:34800000-34914000 gnomAD-SV_v2.1_DUP_17_43954;17:34416538-34629684 dgv3144n100;17:34435513-34629696 esv2760467;17:34436438-34780239 DDD:49240 17:34540766-34540825 gnomAD-SV_v2.1_DEL_17_159956;17:34702019-34702094 DDD:49280;17:34438323-34449809 DDD:49242;17:34509780-34551554 HI40:ISCA-46698;17:34580927-34587273 DDD:49263;17:34750173-34796456 DDD:49284;17:34443777-34537005 DDD:49243;17:34591446-34670592 dgv546e199 17:34446621-34447535 DDD:49246;17:34642332-34642392 gnomAD-SV_v2.1_DEL_17_159958;17:34808750-34815000 gnomAD-SV_v2.1_DEL_17_159959;17:34508446-34554792 dgv545e199;17:34517741-34540630 DDD:49256;17:34625755-34641426 DDD:49271;17:34762644-34775639 DDD:49288;17:34436438-34780239 DDD:49240 1008133;1008390;1008393;1008397;1008403;1008404;1008414;1008416;1008428;1008433;1008436;1016302;1016303;1016304;1017291;1206030;1241176;1314448;1320799;1428723;1505611;1587115;1721282;1868520;1966753;2161178;2208771;2234627;2242284;2563085;2592993;602081;602398;602399;602400;602401;603433;603434;603435;603935;604558;604559;604812;605043;605044;605045;605998;607014;607015;607486;607487;... gain;loss 0.435 0.515 17:34437545-34437861 7SLRNA 17:34405992-34437446;17:34405992-34437446 94.43 2.42746656950142 2.82547992470582 601395 yes 7 3.3576e-01 6.3692e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);3A (9 genes, +0.00);5F (+0.00) 1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL3L1 NM_021006 34623841 34625731 1890 282 100 no 3 txStart-txEnd 5'UTR-3'UTR 34623841 34625731 DDD:49240;dgv122e55;dgv3144n100;esv2760467;esv2762388;nsv514839 17:34610042-34641487;17:34387632-34629696;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34436438-34780239 0.0994 DDD:49240;dgv546e199 17:34436438-34780239;17:34591446-34670592 0.1000 88.49 601395 (HIV/AIDS, susceptibility to), 609423 (3) yes 9 1.2057e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL3L3 NM_001001437 34623841 34625731 1890 282 100 no 3 txStart-txEnd 5'UTR-3'UTR 34623841 34625731 DDD:49240;dgv122e55;dgv3144n100;esv2760467;esv2762388;nsv514839 17:34610042-34641487;17:34387632-34629696;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34436438-34780239 0.0994 DDD:49240;dgv546e199 17:34436438-34780239;17:34591446-34670592 0.1000 88.85 9 3.1517e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL4L1 NM_207007 34538309 34540280 1971 279 100 no 3 txStart-txEnd 5'UTR-3'UTR 34538309 34540280 CMRI:213_pbsv.SPLIT.DUP.926;DDD:49237;DDD:49240;DDD:49256;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34517741-34540630;17:34495255-34583253;17:34387632-34629696;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239 0.0994 DDD:49240;DDD:49256;HI40:ISCA-46698;dgv545e199 17:34508446-34554792;17:34509780-34551554;17:34517741-34540630;17:34436438-34780239 0.1500 86.53 1.10672910487962 0.922019018769221 9 3.3576e-01 4.8086e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL4L2 NM_001291471 34538464 34540274 1810 312 100 no 3 txStart-txEnd 5'UTR-3'UTR 34538464 34540274 CMRI:213_pbsv.SPLIT.DUP.926;DDD:49237;DDD:49240;DDD:49256;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34517741-34540630;17:34495255-34583253;17:34387632-34629696;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239 0.0994 DDD:49240;DDD:49256;HI40:ISCA-46698;dgv545e199 17:34508446-34554792;17:34509780-34551554;17:34517741-34540630;17:34436438-34780239 0.1500 84.65 1.02068766819866 1.31010018701924 9 8.8586e-02 4.8994e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3B NM_001001417 34797171 34808092 10921 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34797171 34808092 dgv122e55 17:34426246-34870708 0.0300 885243 gain 94.43 2.42746656950142 2.41694262394586 7 2.1949e-01 6.3692e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3F NM_032258 34746118 34808058 61940 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34746118 34808058 dgv122e55 17:34426246-34870708 0.0300 604559;605998;607489;719981;755962;793908;844836;848826;848827;863452;880668;884352;885243;890702;892670;895641;897050;910270;921081 gain;loss 93.73 1.8673923772413 2.14567117504116 9 1.3666e-05 6.2038e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3G NM_001291462 34581084 34591982 10898 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34581084 34591982 DDD:49237;DDD:49240;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34387632-34629696;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239 0.0994 DDD:49240 17:34436438-34780239 0.0982 93.75 2.39402604738896 2.82547992470582 4.9000e-01 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3H NM_001123392 34581028 34591996 10968 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34581028 34591996 DDD:49237;DDD:49240;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34387632-34629696;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239 0.0994 DDD:49240 17:34436438-34780239 0.0982 93.12 full=1 -17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3L NM_001369499 34581084 34808058 226974 1833 100 no 13 txStart-txEnd 5'UTR-3'UTR 34581084 34808058 dgv122e55 17:34426246-34870708 0.0300 1016303;1016304;602400;602401;603434;603435;603935;604558;604559;605044;605045;605998;607015;607488;607489;608037;719981;747609;755962;763489;786651;787533;793906;793907;793908;826615;826616;831457;844836;848825;848826;848827;862387;863452;867741;873955;873956;880667;880668;883880;883881;884352;885242;885243;890702;892670;895641;897049;897050;899425;900066;... gain;loss full=1 -17_44171889_44297143_DUP_1 17 44171889 44297143 125254 DUP Benign NA full q21.31 KANSL1;KANSL1-AS1 2 GOSR2 (morbid/RE=GH_Enhancer);NSF (morbid/RE=EA_enhancer) dbVar:nssv15149908;nssv15152170;dbVar:nssv15159024;dbVar:nssv15160732;dbVar:nssv15159027;dbVar:nssv15127236;dbVar:nssv15149626;dbVar:nssv15150382;dbVar:nssv16207328;dbVar:nssv15141990 17:527-81041938;17:7215-81058310;17:8548-81060040;17:12345-81057996;17:16757564-81048189;17:42580685-81085615;17:43655357-44292742;17:43655357-44784639;17:43710151-44292742 0.15;0.15;0.15;0.15;0.19;0.33;18.96;11.09;20.74 Koolen-De Vries syndrome, 610443 (3) AD dbVar:nssv15127168;dbVar:nssv16215146;dbVar:nssv15141350;dbVar:nssv16254531;dbVar:nssv15124147;dbVar:nssv15135761;dbVar:nssv15137490;dbVar:nssv15129570;dbVar:nssv15138300;dbVar:nssv15137112;dbVar:nssv15132122;dbVar:nssv15132318;nssv15133093;dbVar:nssv15135170;dbVar:nssv15132284;nssv15139974;dbVar:nssv15136771;dbVar:nssv15136778;dbVar:nssv15132380;dbVar:nssv15173411;dbVar:nssv15133422;dbVar:nssv15143597;nssv15155552;dbVar:nssv15138826;dbVar:nssv15142266;dbVar:nssv15173506;dbVar:nssv15136011;dbVar:nssv15133428;dbVar:nssv15132370;nssv15140010;dbVar:nssv15132745;dbVar:nssv16091744;dbVar:nssv15135222;dbVar:nssv15161495;dbVar:nssv15129007;dbVar:nssv15152077;dbVar:nssv15132384;dbVar:nssv15136234;dbVar:nssv15132385;dbVar:nssv15133429;morbid:KANSL1;HI3:KANSL1;dbVar:nssv16252231 17:34750819-81048189;17:43559852-44248220;17:43585761-44248995;17:43586397-44212416;17:43592411-44249054;17:43593477-44224221;17:43622198-44201470;17:43629216-44399455;17:43648492-44214888;17:43651732-44351152;17:43653228-44351644;17:43655748-44176717;17:43655748-44224221;17:43655748-44351152;17:43656694-44176717;17:43656694-44694311;17:43675409-44351152;17:43685926-44212727;17:43693608-44176717;17:43703801-44212416;17:43703802-44187492;17:43703802-44212416;17:43705602-44208333;17:43706887-44171947;17:43706887-44176171;17:43706887-44176717;17:43706887-44207977;17:43706887-44210822;17:43706887-44351152;17:43706887-44694283;17:43706896-44762543;17:43710371-44212416;17:43715081-44176717;17:43717704-44345038;17:43717704-44351152;17:43751675-44351152;17:44107282-44302733;17:44107283-44302740;17:44174220-44481307 0.27;11.09;11.63;6.47;11.75;8.30;5.11;16.26;7.59;17.91;17.93;0.93;9.21;18.01;0.93;12.07;18.54;7.75;1.00;7.97;3.23;7.97;7.25;0.01;0.91;1.03;7.20;7.73;19.44;12.69;11.87;8.07;1.05;19.97;19.77;20.89;64.08;64.08;40.03 19 Inborn_genetic_diseases;Intellectual_disability;Koolen-de_Vries_syndrome;Neurodevelopmental_delay CMRI:0_pbsv.SPLIT.DUP.751;DDD:49604;dgv127e55;dgv128e55;dgv3181n100;esv2422002;esv2762433;nsv516807 17:44094472-44364056;17:44109475-44793283;17:44145590-44364158;17:44165804-44362009;17:44170038-44744285;17:43574135-44788194;17:44004973-44811116;17:43655787-44366711 0.2968 esv2762433 17:43574135-44788194 0.0700 17:44223908-44224221 1000g;17:44187493-44292742 dgv938e212;17:44212825-44276618 dgv943e212;17:44230894-44262697 1000g;17:44282840-44286328 CMRI:0_pbsv.SPLIT.DUP.779;17:44109475-44793283 nsv516807;17:44149791-44248860 DDD:49602;17:44165000-44217000 gnomAD-SV_v2.1_DUP_17_44187;17:44165339-44211686 1000g;17:44165703-44291551 nsv514850;17:44170038-44744285 DDD:49604;17:44175518-44443972 DDD:49608;17:44187493-44364056 dgv130e55;17:44194107-44762405 DDD:49611;17:44212745-44369562 gnomAD-SV_v2.1_DUP_17_44188;17:44280980-44369559 DDD:49623;17:44212776-44369604 CMRI:0_pbsv.SPLIT.DUP.775_duplicate1;17:44004973-44811116 dgv127e55; 17:44176395-44176717 1000g;17:44187493-44214094 dgv937e212;17:44209763-44267388 DDD:49612;17:44230894-44262697 1000g;17:44230894-44262697 dgv576e214;17:44094472-44364056 dgv128e55;17:44145590-44364158 dgv3181n100;17:44163926-44293020 dgv367n27;17:44165339-44211686 1000g;17:44165339-44211686 dgv575e214;17:44165804-44362009 esv2422002;17:44170285-44212803 DDD:49606;17:44176859-44397890 DDD:49609;17:44187493-44789621 dgv939e212;17:44208145-44764994 esv2760451;17:44249111-44320939 DDD:49618;17:44283572-44782177 esv3893020;17:43574135-44788194 esv2762433;17:43655787-44366711 CMRI:0_pbsv.SPLIT.DUP.751 17:44176395-44176717 esv2675570;17:44176395-44176717 CMRI:2_pbsv.DEL.1047_duplicate6;17:44223908-44224221 1000g;17:44223908-44224221 CMRI:0_pbsv.DEL.777_duplicate6;17:44170285-44212803 DDD:49606;17:44190672-44785015 dgv940e212;17:44208145-44764994 esv2760451; 17:44176395-44176717 1000g;17:44176407-44176807 gnomAD-SV_v2.1_DEL_17_160649;17:44223760-44224221 gnomAD-SV_v2.1_DEL_17_160652;17:44223908-44224221 esv2662030;17:44212311-44292742 dgv941e212;17:44176859-44397890 DDD:49609;17:44194107-44762405 DDD:49611;17:43574135-44788194 esv2762433 1021567;1021568;1022169;1059374;1083775;1134448;1140557;1145788;1235921;1236152;1248933;1274013;1318059;1357512;1477773;1521080;1523225;1664046;1665693;1763625;1789500;1853738;1943987;1997544;2001804;2027524;2053026;2074112;2081277;2151412;2228707;2282991;2340912;2348966;2410443;2478215;2492757;2539992;2606291;2618991;2644184;2672988;2715621;2750031;2822283;2839546;2876679;2896576;2917676;2953515;2972078;... gain;loss 0.380 0.460 17:44297188-44297495 AluY 17:44164882-44183555 17:44294406-44329730 3 16.23 -0.71959827485963 0.443929223699058 612452 yes 0 9.9972e-01 9.9973e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2I-3 (KANSL1, +0.00);3A (2 genes, +0.00);5F (+0.00) 1 -17_44171889_44297143_DUP_1 17 44171889 44297143 125254 DUP Benign NA split q21.31 KANSL1 NM_001193465 44107281 44302733 125255 1431 43 no 16 intron2-intron4 5'UTR-CDS 37 5' 44171888 44297143 19 Inborn_genetic_diseases;Intellectual_disability;Koolen-de_Vries_syndrome;Neurodevelopmental_delay CMRI:0_pbsv.SPLIT.DUP.751;DDD:49604;dgv127e55;dgv128e55;dgv3181n100;esv2422002;esv2762433;nsv516807 17:44094472-44364056;17:44109475-44793283;17:44145590-44364158;17:44165804-44362009;17:44170038-44744285;17:43574135-44788194;17:44004973-44811116;17:43655787-44366711 0.2968 esv2762433 17:43574135-44788194 0.0700 1021567;1021568;1022169;1059374;1083775;1134448;1140557;1145788;1235921;1236152;1248933;1274013;1318059;1357512;1477773;1521080;1523225;1664046;1665693;1763625;1789500;1853738;1943987;1997544;2001804;2027524;2053026;2074112;2081277;2151412;2228707;2282991;2340912;2348966;2410443;2478215;2492757;2539992;2606291;2618991;2644184;2672988;2715621;2750031;2822283;2839546;2876679;2896576;2917676;2953515;2972078;... gain;loss 3 0 16.23 -0.71959827485963 0.443929223699058 Koolen-de Vries syndrome;Koolen-de Vries syndrome due to a point mutation AD Definitive;Strong;Supportive 22544363;22544363[PMID]_22544367[PMID]_20301783[PMID];22544367 612452 Koolen-De Vries syndrome, 610443 (3) AD AD yes 0 9.9972e-01 9.9973e-01 full=1 -17_44171889_44297143_DUP_1 17 44171889 44297143 125254 DUP Benign NA split q21.31 KANSL1-AS1 NR_034172 44270938 44274089 3151 0 0 no 2 txStart-txEnd UTR 44270938 44274089 CMRI:0_pbsv.SPLIT.DUP.751;CMRI:0_pbsv.SPLIT.DUP.775_duplicate1;DDD:49604;DDD:49608;DDD:49609;DDD:49611;DDD:49618;dgv127e55;dgv128e55;dgv130e55;dgv3181n100;dgv367n27;dgv938e212;dgv939e212;dgv943e212;esv2422002;esv2760451;esv2762433;gnomAD-SV_v2.1_DUP_17_44188;nsv514850;nsv516807 17:44187493-44292742;17:44212825-44276618;17:44094472-44364056;17:44109475-44793283;17:44145590-44364158;17:44163926-44293020;17:44165703-44291551;17:44165804-44362009;17:44170038-44744285;17:44175518-44443972;17:44176859-44397890;17:44187493-44364056;17:44187493-44789621;17:44194107-44762405;17:44208145-44764994;17:44212745-44369562;17:44249111-44320939;17:44212776-44369604;17:43574135-44788194;17:44004973-44811116;17:43655787-44366711 0.5406 DDD:49609;DDD:49611;dgv940e212;dgv941e212;esv2760451;esv2762433 17:44212311-44292742;17:44176859-44397890;17:44190672-44785015;17:44194107-44762405;17:44208145-44764994;17:43574135-44788194 0.2994 full=1 -2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA full q37.3 LINC01237;LINC01238;LINC01880;LOC285097 4 D2HGDH (morbid/RE=EA_enhancer+GH_Enhancer);DTYMK (morbid/RE=EA_enhancer) dbVar:nssv15174359;dbVar:nssv15174602;dbVar:nssv16254741;dbVar:nssv15147151;dbVar:nssv15147318;dbVar:nssv15146760;dbVar:nssv15121191;dbVar:nssv15134347;dbVar:nssv15120707;dbVar:nssv8639299 2:14239-243048760;2:15673-243101834;2:178397960-243007457;2:189682922-243007359;2:211444401-243059659;2:218966483-243059659;2:228667865-243028452;2:236177413-243059659;2:236472309-243028452;2:239873382-243006013 0.07;0.07;0.22;0.27;0.51;0.67;1.13;2.36;2.48;4.47 2q37.3 terminal region (includes HDAC4) dbVar:nssv15124851;dbVar:nssv15132233;nssv15140017;dbVar:nssv16296940;dbVar:nssv15139807;dbVar:nssv15126959;dbVar:nssv15121136;dbVar:nssv15120661;dbVar:nssv15121139;dbVar:nssv15132363;dbVar:nssv15121140;dbVar:nssv15134903;dbVar:nssv15122404;dbVar:nssv15133611;dbVar:nssv15120667;dbVar:nssv16865882;dbVar:nssv15137653;dbVar:nssv15132686;dbVar:nssv17976287;dbVar:nssv15136836;dbVar:nssv15133934;dbVar:nssv15133750;dbVar:nssv15163370;dbVar:nssv15134792;dbVar:nssv15133170;dbVar:nssv15132355;dbVar:nssv15605955;dbVar:nssv15137339;dbVar:nssv15605956;dbVar:nssv15136036;dbVar:nssv15755694;HI3:ISCA-37394;dbVar:nssv15121144;dbVar:nssv15135054;dbVar:nssv15133743;dbVar:nssv15135857;dbVar:nssv15120673;dbVar:nssv15133620;dbVar:nssv15122695;dbVar:nssv15163383;dbVar:nssv16207882;dbVar:nssv15141519;dbVar:nssv15121145 2:50886433-243102476;2:232634990-243059659;2:233110453-243028452;2:233784244-243040217;2:233891214-243068334;2:233995841-243028452;2:234362258-243041306;2:235081181-243028452;2:235254487-243059659;2:235576804-243059659;2:235744425-243007359;2:235937074-243008259;2:236177413-243007359;2:236649724-242974607;2:237201757-243048760;2:237322366-243059659;2:237463877-243059659;2:237619066-243048655;2:237684406-243059659;2:237875407-243007359;2:237943120-243007359;2:238037760-243101834;2:238140848-243007359;2:238434828-242938241;2:238552640-243059659;2:238795603-242918203;2:238811513-243059659;2:239071624-243048760;2:239742161-243059659;2:239894073-243048760;2:239954694-242930600;2:241006624-243028452;2:241006624-243059659;2:241110555-243007359;2:241127319-243059659;2:241384237-243028452;2:241446569-243007359;2:241610649-243034277;2:241847590-243101834;2:242011634-243199373;2:242045570-243040217;2:242188711-243028452 0.08;1.56;1.64;1.76;1.77;1.80;1.87;2.05;2.08;2.17;1.95;2.01;2.07;1.72;2.78;2.83;2.90;2.99;3.02;2.76;2.79;3.21;2.91;1.61;3.61;1.27;3.83;4.09;4.90;5.15;2.17;8.04;7.92;7.46;8.41;9.89;9.06;11.42;12.96;13.68;16.34;19.35 DDD:9221;DDD:9222;gnomAD-SV_v2.1_DEL_2_28790 2:242849685-243064401;2:242853252-243035778;2:242853253-243035778 0.0686 2:242895938-242896036 gnomAD-SV_v2.1_DUP_2_7717;2:242975100-242975239 gnomAD-SV_v2.1_DUP_2_7738;2:243027554-243069648 1000g;2:242930601-243102476 TS40:ISCA-37470;2:242988770-243037176 dgv768e214 2:242869815-242870699 gnomAD-SV_v2.1_DUP_2_7710;2:242931651-242931989 gnomAD-SV_v2.1_DUP_2_7720;2:243028400-243028975 nsv514985;2:243027554-243069648 dgv769e214;2:242988770-243037176 1000g 2:242898332-242898462 gnomAD-SV_v2.1_DEL_2_28796;2:242898343-242898462 CMRI:2_pbsv.DEL.3934;2:242921625-242921734 gnomAD-SV_v2.1_DEL_2_28798;2:242937071-242937144 1000g;2:242937071-242937144 CMRI:119_pbsv.DEL.3982;2:242945645-242945965 esv2663714;2:242949202-242949371 gnomAD-SV_v2.1_DEL_2_28809;2:242952053-242952165 gnomAD-SV_v2.1_DEL_2_28822;2:242945870-242946125 CMRI:2_pbsv.DEL.3942;2:242948316-242953009 CMRI:11_pbsv.DEL.5677;2:242948632-242949639 CMRI:13_pbsv.DEL.4420;2:242948717-242951194 CMRI:4_pbsv.DEL.4561;2:242948762-242951618 CMRI:2_pbsv.DEL.3943;2:242949159-242951889 CMRI:2_pbsv.DEL.3945;2:242950083-242951595 CMRI:3_pbsv.DEL.4744;2:242950371-242952723 CMRI:2_pbsv.DEL.3946;2:242950589-242952521 CMRI:8_pbsv.DEL.3973;2:242951025-242952243 CMRI:63_pbsv.DEL.3820;2:242951220-242952228 CMRI:13_pbsv.DEL.4423;2:242961883-242961998 gnomAD-SV_v2.1_DEL_2_28827;2:242965502-242970777 1000g... 2:242871536-242871680 CMRI:35_pbsv.DEL.3967;2:242898343-242898462 1000g;2:242921620-242921754 1000g;2:242922176-242922234 gnomAD-SV_v2.1_DEL_2_28799;2:242927696-242927969 CMRI:2_pbsv.DEL.3937;2:242945464-242945548 1000g;2:242949196-242949373 gnomAD-SV_v2.1_DEL_2_28808;2:242949242-242949430 gnomAD-SV_v2.1_DEL_2_28810;2:242945632-242946023 CMRI:0_pbsv.DEL.3097;2:242945934-242946023 CMRI:53_pbsv.DEL.4065;2:242948598-242950314 CMRI:43_pbsv.DEL.3912;2:242948698-242952520 CMRI:12_pbsv.DEL.3838;2:242948762-242949307 CMRI:31_pbsv.DEL.4006;2:242948847-242952207 CMRI:44_pbsv.DEL.3385;2:242949918-242950337 CMRI:90_pbsv.DEL.3914;2:242950233-242950736 CMRI:40_pbsv.DEL.3946;2:242950420-242952562 CMRI:7_pbsv.DEL.3778;2:242950839-242952729 CMRI:4_pbsv.DEL.4563;2:242951175-242952645 CMRI:3_pbsv.DEL.4746;2:242951968-242952345 CMRI:31_pbsv.DEL.4008;2:242962242-242968684 gnomAD-SV_v2.1_DEL_2_28828... 0.400 0.460 2:243007680-243062019 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (4 genes, +0.00);5F (+0.00) 1 -2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LINC01237 NR_110220 242823513 243020873 154953 0 0 no 4 intron2-txEnd UTR 41134 5' 242865920 243020873 DDD:9211;DDD:9221;DDD:9222;gnomAD-SV_v2.1_DEL_2_28790 2:242702555-243025545;2:242849685-243064401;2:242853252-243035778;2:242853253-243035778 0.0686 full=1 -2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LINC01238 NR_110592 242912833 242919427 6594 0 0 no 6 txStart-txEnd UTR 242912833 242919427 1000g;DDD:9211;DDD:9221;DDD:9222;DDD:9226;HI40:ISCA-46585;dgv165e55;esv3594850;esv3594853;gnomAD-SV_v2.1_DEL_2_28790 2:242890092-242926595;2:242890092-242926595;2:242516106-243014630;2:242702555-243025545;2:242849685-243064401;2:242853244-243019021;2:242853244-243019021;2:242853252-243035778;2:242853253-243035778;2:242867313-242921118;2:242872863-243012181 0.0686 full=1 -2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LINC01880 NR_146651 242989834 243026289 36455 0 0 no 4 txStart-txEnd UTR 242989834 243026289 1000g;TS40:ISCA-37470;dgv768e214 2:242930601-243102476;2:242988770-243037176;2:242988770-243037176 0.0951 1000g;DDD:9221;DDD:9222;DDD:9235;HI40:ISCA-37470;dgv4203n100;dgv498n27;dgv90e203;esv3594857;esv3594864;gnomAD-SV_v2.1_DEL_2_28790 2:242849685-243064401;2:242853252-243035778;2:242853253-243035778;2:242915455-243049013;2:242915467-243089456;2:242917307-243044147;2:242922232-243083979;2:242930601-243102476;2:242944059-243035710;2:242944059-243035710;2:242988770-243037176;2:242988770-243037176 0.0804 full=1 -2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LOC285097 NR_149023 242943359 242948162 4803 0 0 no 1 txStart-txEnd UTR 242943359 242948162 TS40:ISCA-37470 2:242930601-243102476 1000g;CMRI:53_pbsv.DEL.4062;DDD:9211;DDD:9221;DDD:9222;DDD:9231;DDD:9235;HI40:ISCA-37470;HI40:ISCA-46585;dgv165e55;dgv167e55;dgv4203n100;dgv498n27;dgv90e203;esv3594850;esv3594855;gnomAD-SV_v2.1_DEL_2_28790;gnomAD-SV_v2.1_DEL_2_28801 2:242919211-242952227;2:242919211-242952227;2:242919289-242952148;2:242936128-242980024;2:242919315-242949234;2:242516106-243014630;2:242702555-243025545;2:242849685-243064401;2:242853244-243019021;2:242853244-243019021;2:242853252-243035778;2:242853253-243035778;2:242872863-243012181;2:242915455-243049013;2:242915467-243089456;2:242917307-243044147;2:242918249-243014630;2:242922232-243083979;2:242930601-243102476 0.0804 full=1 -3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA full q29 MIR570;MIR570HG;MUC20 3 ABCB7 (morbid/RE=mTL_miRNA);ABHD5 (morbid/RE=mTL_miRNA);ADAM22 (morbid/RE=mTL_miRNA);ANXA11 (morbid/RE=mTL_miRNA);ATP6V1B2 (morbid/RE=mTL_miRNA);BICD2 (morbid/RE=mTL_miRNA);BTD (morbid/RE=mTL_miRNA);CALM1 (morbid/RE=mTL_miRNA);CALM3 (morbid/RE=mTL_miRNA);CAVIN1 (morbid/RE=mTL_miRNA);CCDC115 (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CHD1 (morbid/RE=mTL_miRNA);CHSY1 (morbid/RE=mTL_miRNA);CLCN3 (morbid/RE=mTL_miRNA);CRTAP (morbid/RE=mTL_miRNA);CSNK2A1 (morbid/RE=mTL_miRNA);DDHD1 (morbid/RE=mTL_miRNA);ELOVL5 (morbid/RE=mTL_miRNA);EPG5 (morbid/RE=mTL_miRNA);ESCO2 (morbid/RE=mTL_miRNA);EXOC2 (morbid/RE=mTL_miRNA);FBXW7 (morbid/RE=mTL_miRNA);GDF6 (morbid/RE=mTL_miRNA);GSR (morbid/RE=mTL_miRNA);IGF1R (morbid/RE=mTL_miRNA);IL6R (morbid/RE=mTL_miRNA);IREB2 (morbid/RE=mTL_miRNA);KCNB1 (morbid/RE=mTL_miRNA);KLHL15 (morbid/RE=mTL_miRNA);KREMEN1 (morbid/RE=mTL_miRNA);LEMD2 (morbid/RE=mTL_miRNA);MRPL3 (morbid/RE=mTL_miRNA);MYO1C (morbid/RE=mTL_miRNA);NDRG1 (morbid/RE=mTL_miRNA);NDUFA12 (morbid/RE=mTL_miRNA);P3H2 (morbid/RE=mTL_miRNA);PAX2 (HI=3/morbid/RE=mTL_miRNA);PEX2 (morbid/RE=mTL_miRNA);PGK1 (morbid/RE=mTL_miRNA);PHF6 (HI=3/morbid/RE=mTL_miRNA);RAC1 (morbid/RE=mTL_miRNA);RNF168 (morbid/RE=GH_Enhancer);SAMD12 (morbid/RE=mTL_miRNA);SETD5 (HI=3/morbid/RE=mTL_miRNA);SOX3 (morbid/RE=mTL_miRNA);TACR3 (morbid/RE=mTL_miRNA);TFRC (morbid/RE=EA_enhancer);TGFBR2 (morbid/RE=mTL_miRNA);TNFRSF10B (morbid/RE=mTL_miRNA);TPM3 (morbid/RE=mTL_miRNA);TRIP13 (morbid/RE=mTL_miRNA);VMA21 (morbid/RE=mTL_miRNA);WARS2 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA) dbVar:nssv15162889;dbVar:nssv15164144;dbVar:nssv15149891;nssv15151839;dbVar:nssv15148025;dbVar:nssv15146977;dbVar:nssv15145927;dbVar:nssv15147555;dbVar:nssv15147518;dbVar:nssv15145707;dbVar:nssv15149548;dbVar:nssv15148262;dbVar:nssv15146719;dbVar:nssv15164224;dbVar:nssv15147464;dbVar:nssv15148839;dbVar:nssv15142547;dbVar:nssv15153539;dbVar:nssv15153542;dbVar:nssv15153544;dbVar:nssv15164241;dbVar:nssv15152868;dbVar:nssv15755821;dbVar:nssv15146377;dbVar:nssv15146980;dbVar:nssv15153546;dbVar:nssv15145873;dbVar:nssv15149008;dbVar:nssv15145905;dbVar:nssv15146981;dbVar:nssv16254509;dbVar:nssv16736615;dbVar:nssv15148110 3:60175-197948027;3:61496-197838262;3:61893-197851986;3:103145727-197837049;3:147239680-197823436;3:151818302-197845254;3:155836231-197851986;3:156039668-197840323;3:157011168-197861598;3:158980632-197766890;3:165854998-197851986;3:167885357-197837049;3:173281267-197838262;3:175886314-197845254;3:176157700-197845254;3:177246494-197837049;3:182539235-197851986;3:184003968-197851986;3:186374366-197851986;3:186374672-197838262;3:187913568-197851986;3:188386567-197838262;3:188983161-197837049;3:190385453-197837049;3:191593620-197851986;3:192470727-197845254;3:193422395-197851986;3:194013987-197837069;3:194145226-197895629;3:195068029-197851986;3:195419169-197387258;3:195438670-197837049 0.03;0.03;0.03;0.06;0.11;0.12;0.13;0.13;0.13;0.14;0.17;0.18;0.22;0.24;0.25;0.26;0.35;0.39;0.47;0.47;0.54;0.57;0.61;0.72;0.86;1.00;1.21;1.40;1.43;1.93;2.73;1.43 dbVar:nssv15146266;dbVar:nssv15128822;dbVar:nssv15165459;dbVar:nssv17955845;dbVar:nssv17955930;dbVar:nssv15145831 3:185203638-197837049;3:185599935-196462295;3:189101447-197838262;3:189608637-197532175;3:191866467-197842171;3:194059264-197420612 0.42;0.49;0.61;0.68;0.90;1.60 CMRI:3_pbsv.SPLIT.DUP.3492;CMRI:6_pbsv.SPLIT.DUP.3391;DDD:12528;TS40:ISCA-46592;esv2760775;esv2763776 3:195240825-195502119;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;3:195348012-195476032;3:195350032-195477796 0.3386 DDD:12528;esv2760775;esv2763776 3:195240825-195502119;3:195383143-195502119;3:195385823-195474165 0.0300 3:195429528-195429634 CMRI:0_pbsv.INS.DUP.2131;3:195452013-195457240 1000g;3:195454692-195475463 DDD:12537;3:195457142-195468593 1000g;3:195457142-195468593 dgv969e214;3:195320057-195470538 DDD:12519;3:195383143-195502119 esv2760775;3:195417631-195471708 DDD:12530;3:195417836-195445776 1000g;3:195417836-195445776 1000g;3:195428197-195442889 nsv515001;3:195348012-195476032 CMRI:6_pbsv.SPLIT.DUP.3391; 3:195429509-195429624 gnomAD-SV_v2.1_DUP_3_10620;3:195452013-195457240 1000g;3:195452013-195457240 dgv968e214;3:195457000-195471300 gnomAD-SV_v2.1_DUP_3_10621;3:195457142-195468593 1000g;3:195240825-195502119 esv2763776;3:195376589-195493533 TS40:ISCA-46592;3:195385823-195474165 DDD:12528;3:195417836-195445776 1000g;3:195417836-195445776 1000g;3:195417836-195445776 dgv967e214;3:195341294-195447355 CMRI:74_pbsv.SPLIT.DUP.2243;3:195350032-195477796 CMRI:3_pbsv.SPLIT.DUP.3492 3:195421669-195421737 CMRI:0_pbsv.DEL.2128;3:195437319-195437858 CMRI:1_pbsv.DEL.2123_duplicate1;3:195439622-195439797 CMRI:21_pbsv.DEL.2405_duplicate1;3:195439791-195441152 CMRI:19_pbsv.DEL.2307;3:195439865-195440015 CMRI:25_pbsv.DEL.2723_duplicate1;3:195440145-195440848 CMRI:1_pbsv.DEL.2126_duplicate1;3:195440337-195440516 CMRI:14_pbsv.DEL.2799_duplicate1;3:195440557-195440848 CMRI:54_pbsv.DEL.2766_duplicate3;3:195440662-195440928 CMRI:36_pbsv.DEL.2835_duplicate2;3:195440974-195441215 CMRI:28_pbsv.DEL.3247_duplicate2;3:195451992-195452504 CMRI:0_pbsv.DEL.2137_duplicate3;3:195452019-195452303 CMRI:5_pbsv.DEL.2788;3:195452265-195452491 CMRI:4_pbsv.DEL.3463_duplicate2;3:195454692-195475463 DDD:12537;3:195457249-195471074 dgv906e199;3:195453948-195473005 CMRI:13_pbsv.DEL.3156;3:195240825-195502119 esv2763776;3:195380279-195469564 HI40:ISCA-46589;3:195383143-195502119 esv2760775;3:195417631-195471708 DDD:12530 3:195421470-195421607 CMRI:2_pbsv.DEL.2785_duplicate1;3:195426126-195426208 CMRI:4_pbsv.DEL.3457_duplicate1;3:195437841-195438245 CMRI:1_pbsv.DEL.2124;3:195439643-195440318 CMRI:1_pbsv.DEL.2125_duplicate1;3:195439849-195440527 CMRI:30_pbsv.DEL.3952;3:195440117-195440319 CMRI:10_pbsv.DEL.2333_duplicate2;3:195440232-195440527 CMRI:28_pbsv.DEL.3244_duplicate1;3:195440440-195441153 CMRI:8_pbsv.DEL.2721;3:195440647-195440849 CMRI:14_pbsv.DEL.2800;3:195440676-195440791 CMRI:25_pbsv.DEL.2724_duplicate1;3:195441087-195441275 CMRI:10_pbsv.DEL.2334_duplicate3;3:195452019-195452189 CMRI:0_pbsv.DEL.2138_duplicate1;3:195452250-195452648 CMRI:15_pbsv.DEL.2742_duplicate1;3:195462136-195470948 CMRI:3_pbsv.DEL.3519;3:195457142-195471062 dgv970e214;3:195457318-195471062 1000g;3:195457229-195471262 CMRI:6_pbsv.DEL.3424_duplicate2;3:195320057-195470538 DDD:12519;3:195383131-195446910 dgv5017n100;3:195385823-195474165 DDD:12528 1019080;1066092;1158545;650094;650802;662061;665255;666582;668577;669297;674311;676953;689440;690004;703362;794136;838978;915282 gain;loss 0.470 0.415 3:195418975-195419071 MER3 3:195413607-195420395 3:195341901-195476900 High Signal Region 3:195341901-195476900 High Signal Region 95.22 6 4.7211e-03 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (3 genes, +0.00);5F (+0.00) 1 -3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA split q29 MIR570 NR_030296 195426271 195426368 97 0 0 no 1 txStart-txEnd UTR 195426271 195426368 1000g;CMRI:3_pbsv.SPLIT.DUP.3492;CMRI:6_pbsv.SPLIT.DUP.3391;CMRI:74_pbsv.SPLIT.DUP.2243;DDD:12519;DDD:12528;DDD:12530;TS40:ISCA-46592;dgv967e214;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195341294-195447355;3:195348012-195476032;3:195350032-195477796 0.4682 DDD:12519;DDD:12528;DDD:12530;HI40:ISCA-46589;dgv5017n100;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195380279-195469564;3:195383131-195446910;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708 0.0746 full=1 -3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA split q29 MIR570HG NR_122105 195415368 195438746 19578 0 0 no 5 intron2-txEnd UTR 2859 5' 195419168 195438746 1000g;CMRI:3_pbsv.SPLIT.DUP.3492;CMRI:6_pbsv.SPLIT.DUP.3391;CMRI:74_pbsv.SPLIT.DUP.2243;DDD:12519;DDD:12528;DDD:12530;TS40:ISCA-46592;dgv967e214;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195341294-195447355;3:195348012-195476032;3:195350032-195477796 0.4682 DDD:12519;DDD:12528;DDD:12530;HI40:ISCA-46589;dgv5017n100;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195380279-195469564;3:195383131-195446910;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708 0.0746 full=1 -3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA split q29 MUC20 NM_001282506 195447848 195460422 12574 2130 100 no 4 txStart-txEnd 5'UTR-3'UTR 195447848 195460422 CMRI:3_pbsv.SPLIT.DUP.3492;CMRI:6_pbsv.SPLIT.DUP.3391;DDD:12519;DDD:12528;DDD:12530;TS40:ISCA-46592;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708;3:195348012-195476032;3:195350032-195477796 0.3386 DDD:12519;DDD:12528;DDD:12530;HI40:ISCA-46589;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195380279-195469564;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708 0.0746 95.22 6 4.7211e-03 full=1 -4_69392546_69462438_DEL_1 4 69392546 69462438 -69892 DEL Benign NA full q13.2 UGT2B17 1 dbVar:nssv15165478;dbVar:nssv15148693;dbVar:nssv15165480;dbVar:nssv15164282;dbVar:nssv15149870;nssv15151360;dbVar:nssv15145710;dbVar:nssv17956560;dbVar:nssv15153593;dbVar:nssv15774461 4:11526-191028879;4:12441-190904441;4:49451-190915650;4:49451-190963766;4:68347-190957473;4:52697789-98426769;4:52866945-143582507;4:64705502-73469716;4:68242785-82991431 0.04;0.04;0.04;0.04;0.04;0.15;0.08;0.80;0.47 dbVar:nssv17173265;dbVar:nssv15165214;dbVar:nssv15125766;dbVar:nssv17969950;dbVar:nssv15141158;dbVar:nssv15132956;dbVar:nssv15132546;dbVar:nssv15137205;dbVar:nssv17976281;dbVar:nssv16207960 4:52757981-76930872;4:58332295-71587615;4:59167246-101910659;4:61867556-74711517;4:66017576-76772947;4:66320281-73179410;4:67708127-71697274;4:68665384-75106637;4:68698774-83637218;4:68950364-79738598 0.29;0.53;0.16;0.54;0.65;1.02;1.75;1.09;0.47;0.65 DDD:13999;dgv1490e212;dgv5262n100;dgv5264n100 4:69360477-69485827;4:69364694-69524016;4:69371992-69489323;4:69371992-69540013 0.4178 1000g;DDD:13999;DDD:14001;DDD:14006;dgv5262n100;dgv951e199;esv2421501;esv3600874;esv3893940;gnomAD-SV_v2.1_DEL_4_46338;nsv514223 4:69364694-69524016;4:69367085-69542363;4:69371992-69489323;4:69372046-69491392;4:69373811-69491113;4:69374942-69503681;4:69375592-69491543;4:69375592-69491543;4:69380302-69491200;4:69382081-69512905;4:69386966-69483317 0.8518 4:69360477-69485827 dgv1490e212;4:69371992-69489323 dgv5262n100;4:69435890-69485966 dgv1493e212; 4:69366026-69430178 DDD:14000;4:69364694-69524016 DDD:13999;4:69371992-69540013 dgv5264n100;4:69435890-69551731 dgv1495e212 4:69366026-69430178 DDD:14000;4:69373748-69423167 esv3600873;4:69426440-69454553 1000g;4:69364694-69524016 DDD:13999;4:69371992-69489323 dgv5262n100;4:69373811-69491113 gnomAD-SV_v2.1_DEL_4_46338;4:69375592-69491543 1000g;4:69380302-69491200 DDD:14006;4:69386966-69483317 nsv514223;4:69435890-69558258 dgv1496e212 4:69360489-69396466 DDD:13998;4:69373748-69423167 1000g;4:69374942-69396466 DDD:14004;4:69426440-69454553 esv3600875;4:69367085-69542363 DDD:14001;4:69372046-69491392 dgv951e199;4:69374942-69503681 esv2421501;4:69375592-69491543 esv3600874;4:69382081-69512905 esv3893940;4:69435890-69485966 dgv1494e212 1066120;1223404;1397960;1447809;2109610;2228872;2279170;2285811;2484300;2666915;2954216 gain;loss 0.400 0.365 4:69392108-69392544 Tigger2a 4:69462528-69462751 THE1B 4:69370649-69435791 87.45 0.741987855668132 1.6951286981971 601903 yes 5 9.6905e-08 1.0256e-02 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 -4_69392546_69462438_DEL_1 4 69392546 69462438 -69892 DEL Benign NA split q13.2 UGT2B17 NM_001077 69402892 69442040 39148 1593 100 no 7 txStart-txEnd 5'UTR-3'UTR 69402892 69442040 DDD:13999;dgv1490e212;dgv5262n100;dgv5264n100 4:69360477-69485827;4:69364694-69524016;4:69371992-69489323;4:69371992-69540013 0.4178 1000g;DDD:13999;DDD:14001;DDD:14006;dgv5262n100;dgv951e199;esv2421501;esv3600874;esv3893940;gnomAD-SV_v2.1_DEL_4_46338;nsv514223 4:69364694-69524016;4:69367085-69542363;4:69371992-69489323;4:69372046-69491392;4:69373811-69491113;4:69374942-69503681;4:69375592-69491543;4:69375592-69491543;4:69380302-69491200;4:69382081-69512905;4:69386966-69483317 0.8518 1397960 gain 87.45 0.741987855668132 1.6951286981971 601903 (Bone mineral density QTL 12, osteoporosis), 612560 (3) yes 5 9.6905e-08 1.0256e-02 full=1 -6_266080_362290_DEL_1 6 266080 362290 -96210 DEL Benign NA full p25.3 DUSP22 1 EXOC2 (morbid/RE=EA_enhancer+GH_Promoter/Enhancer) dbVar:nssv15166690;dbVar:nssv15132417;dbVar:nssv15166692;dbVar:nssv15120571;dbVar:nssv17649861;dbVar:nssv15138806;dbVar:nssv15150238;dbVar:nssv15136852;dbVar:nssv15137715;dbVar:nssv15139508;dbVar:nssv15139953;dbVar:nssv15154408;dbVar:nssv15154409;dbVar:nssv15772668;dbVar:nssv15161578;dbVar:nssv15161859;nssv15161868;dbVar:nssv15132517;dbVar:nssv15133942;dbVar:nssv15135449;dbVar:nssv15131978;dbVar:nssv15168255;dbVar:nssv15124407;nssv15153178;dbVar:nssv15124483;dbVar:nssv16255328 6:60108-171054786;6:106432-18360826;6:108667-170980171;6:144958-5239414;6:149620-3951208;6:152635-14417234;6:152635-15732394;6:152635-6027780;6:155808-17058645;6:156975-11551050;6:156975-13081433;6:156975-13502033;6:156975-21955964;6:156975-23221621;6:156975-46757028;6:156976-170919482;6:163084-1951585;6:163084-2029765;6:163084-9525729;6:164361-13340113;6:165633-170919470;6:168776-24023234;6:255351-3189972;6:302184-3290583 0.06;0.53;0.06;1.89;2.53;0.67;0.62;1.64;0.57;0.84;0.74;0.72;0.44;0.42;0.21;0.06;5.38;5.15;1.03;0.73;0.06;0.40;3.28;2.01 dbVar:nssv15127418;dbVar:nssv15133557;dbVar:nssv15168254;dbVar:nssv15134981;dbVar:nssv15135893;dbVar:nssv15139184;dbVar:nssv16254736;dbVar:nssv15139679;dbVar:nssv15151182;dbVar:nssv16208808;dbVar:nssv15152915;dbVar:nssv15137052;dbVar:nssv15142299;dbVar:nssv15138353;dbVar:nssv15133558;dbVar:nssv15134713;dbVar:nssv15132439;dbVar:nssv15132039;dbVar:nssv15133559;dbVar:nssv15132182;dbVar:nssv15132440;dbVar:nssv15137716;dbVar:nssv15125242;dbVar:nssv15141126;dbVar:nssv15124398;dbVar:nssv15124411 6:60524-1768235;6:107683-4979015;6:108667-1505511;6:152635-5315912;6:152635-6027780;6:152635-6290037;6:152850-1888703;6:156975-13856156;6:156975-2030623;6:156975-2208360;6:156975-3398920;6:156975-4907926;6:156975-6417749;6:156975-7122992;6:163084-2724845;6:163084-3459841;6:163084-5875635;6:163084-6063033;6:164634-5823834;6:164634-6284470;6:165676-9036267;6:170427-1622218;6:180960-2180143;6:195230-2117379;6:204010-11608587;6:204010-6447311 5.63;1.98;6.89;1.86;1.64;1.57;5.54;0.70;5.13;4.69;2.97;2.03;1.54;1.38;3.76;2.92;1.68;1.63;1.70;1.57;1.08;6.63;4.81;5.01;0.84;1.54 DDD:19553;DDD:19555;dgv140e203;nsv514340 6:230528-373346;6:236002-373603;6:257333-380527;6:257354-382897 0.6839 DDD:19555;dgv1701e212 6:236002-373603;6:254255-385771 0.1870 6:298701-379015 esv2421645;6:305182-340601 1000g;6:327587-368712 1000g;6:327587-368712 dgv1159e214;6:230528-373346 DDD:19553;6:253364-294911 dgv1694e212;6:256503-293373 1000g;6:257333-380527 nsv514340;6:257354-294837 esv2421434;6:259529-339802 TS40:ISCA-37471 6:294125-385771 dgv1705e212;6:305182-340601 1000g;6:305182-340601 dgv1158e214;6:327587-368712 1000g;6:344136-379149 DDD:19570;6:236002-373603 DDD:19555;6:253364-302293 dgv1695e212;6:256503-293373 dgv1157e214;6:257354-293393 DDD:19561;6:257354-382897 dgv140e203 6:325237-325486 CMRI:28_pbsv.DEL.4_duplicate2;6:326491-326553 CMRI:0_pbsv.DEL.3_duplicate3;6:252694-302294 dgv1693e212;6:259529-339802 HI40:ISCA-37471 6:295586-296060 gnomAD-SV_v2.1_DEL_6_65910;6:325774-325897 CMRI:3_pbsv.DEL.7_duplicate4;6:236002-373603 DDD:19555;6:254255-385771 dgv1701e212 1068500;1072273;1429292;1591974;1807702;1905160;1938466;2603845;609630;744870;744873;744881;746818;747174;857006;857659;857660;887275;902698;994363 gain;loss 0.365 0.315 6:266156-266836 L1MC3 6:362320-362381 MIRc 6:256601-382800 High Signal Region 6:256601-382800 High Signal Region 38.68 -1.35330421932959 -0.982727799381157 5 9.3421e-03 4.3071e-03 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 -6_266080_362290_DEL_1 6 266080 362290 -96210 DEL Benign NA split p25.3 DUSP22 NM_001286555 292056 351355 59299 618 100 no 7 txStart-txEnd 5'UTR-3'UTR 292056 351355 DDD:19553;DDD:19555;dgv140e203;nsv514340 6:230528-373346;6:236002-373603;6:257333-380527;6:257354-382897 0.6839 DDD:19555;dgv1701e212 6:236002-373603;6:254255-385771 0.1870 1068500;1072273;1429292;1591974;1938466;744870;744873;744881;746818;747174;857660;887275;902698;994363 gain;loss 38.68 -1.35330421932959 -0.982727799381157 5 9.3421e-03 4.3071e-03 full=1 -7_38296177_38352444_DEL_1 7 38296177 38352444 -56267 DEL Benign NA full p14.1 TARP 1 dbVar:nssv15777247;dbVar:nssv15168013;dbVar:nssv15161666;nssv15161679;dbVar:nssv15168014;dbVar:nssv15161726;dbVar:nssv15161869;dbVar:nssv17970205;dbVar:nssv15154527;dbVar:nssv15146465;dbVar:nssv15166972 7:10366-159119707;7:10705-159122532;7:43362-159119707;7:44936-159126310;7:54186-41915483;7:11048841-52863626;7:27507833-39072473;7:30463887-43470805;7:33367925-61831899;7:37213109-40255122 0.04;0.04;0.04;0.04;0.13;0.13;0.49;0.43;0.20;1.85 dbVar:nssv15161318;dbVar:nssv15147510;dbVar:nssv15148432;dbVar:nssv15147453;dbVar:nssv15145850;dbVar:nssv15148950 7:54186-159075079;7:32718004-41084581;7:32911004-44576005;7:35500387-42053399;7:37343083-48700334;7:38217602-45343699 0.04;0.67;0.48;0.86;0.50;0.79 dgv1888e212 7:38286516-38394857 0.0100 CMRI:88_pbsv.DEL.851_duplicate3 7:38293031-38369940 0.0697 7:38286516-38394857 dgv1888e212 7:38283523-38309532 DDD:23873 7:38293018-38339413 gnomAD-SV_v2.1_DEL_7_80142;7:38315910-38331224 gnomAD-SV_v2.1_DEL_7_80145;7:38293031-38369940 CMRI:88_pbsv.DEL.851_duplicate3;7:38309136-38393317 CMRI:5_pbsv.DEL.898_duplicate2;7:38315914-38339406 CMRI:150_pbsv.DEL.643_duplicate4 7:38330122-38330172 CMRI:1_pbsv.DEL.629_duplicate4;7:38296500-38391000 gnomAD-SV_v2.1_DEL_7_80144;7:38293028-38331216 CMRI:40_pbsv.DEL.811_duplicate1;7:38309131-38369942 CMRI:2_pbsv.DEL.864_duplicate4;7:38309138-38356614 CMRI:209_pbsv.DEL.826_duplicate2 0.365 0.320 7:38296252-38296527 AluSx 7:38284220-38298557 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 -7_38296177_38352444_DEL_1 7 38296177 38352444 -56267 DEL Benign NA split p14.1 TARP NM_001003806 38299243 38313248 14005 336 100 no 4 txStart-txEnd 5'UTR-3'UTR 38299243 38313248 dgv1888e212 7:38286516-38394857 0.0100 CMRI:40_pbsv.DEL.811_duplicate1;CMRI:88_pbsv.DEL.851_duplicate3;gnomAD-SV_v2.1_DEL_7_80142;gnomAD-SV_v2.1_DEL_7_80144 7:38293018-38339413;7:38296500-38391000;7:38293028-38331216;7:38293031-38369940 0.0697 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA full p23.1 DEFB103A;DEFB103B;DEFB104A;DEFB104B;DEFB105A;DEFB105B;DEFB106A;DEFB106B;DEFB107A;DEFB107B;DEFB109B;DEFB4A;DEFB4B;FAM66B;FAM90A10P;FAM90A7P;PRR23D1;PRR23D2;SPAG11A;SPAG11B;USP17L1;USP17L4;ZNF705G 23 MCPH1 (morbid/RE=GH_Promoter/Enhancer) dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161508;dbVar:nssv15161747;dbVar:nssv17957391;dbVar:nssv15154583;dbVar:nssv15161801;nssv15777239;dbVar:nssv15154584;dbVar:nssv16206921;dbVar:nssv15154580;dbVar:nssv15161417;nssv15161657;dbVar:nssv15147671;dbVar:nssv15161846;dbVar:nssv15150473;dbVar:nssv15127651;dbVar:nssv15149098;dbVar:nssv15169210;dbVar:nssv15154582;dbVar:nssv15146537;dbVar:nssv15161807;dbVar:nssv15161553;dbVar:nssv15161105;dbVar:nssv15161095;dbVar:nssv15161561;dbVar:nssv15161078;dbVar:nssv15147455;dbVar:nssv16736635;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161749;dbVar:nssv15143576;dbVar:nssv15161775;dbVar:nssv15146180;dbVar:nssv15161087;dbVar:nssv15161068;dbVar:nssv15161792;dbVar:nssv15606063;dbVar:nssv15151542;dbVar:nssv15161084;dbVar:nssv16206931;dbVar:nssv15154577;dbVar:nssv15161089;dbVar:nssv15151538;dbVar:nssv15152254;dbVar:nssv15161540;dbVar:nssv15161727;dbVar:nssv15161764 8:10214-146293414;8:13939-146304022;8:46311-11879315;8:46311-30472220;8:158049-11936107;8:158049-13974319;8:158049-146295771;8:158049-15423270;8:158049-8102819;8:158049-9750676;8:158050-146295771;8:158992-13304906;8:158992-146280828;8:158992-17536147;8:163683-46938942;8:164985-11860845;8:164985-146293414;8:168484-13147575;8:169854-10022996;8:176453-12556063;8:176453-12570496;8:176453-146294098;8:176453-16137655;8:176453-34349408;8:176453-37879246;8:176453-7838959;8:176815-43396776;8:191531-146274835;8:191531-146280020;8:191531-17536206;8:191531-22404983;8:191531-23055911;8:191531-7752586;8:191606-146280167;8:191606-24514484;8:191606-30948590;8:194618-13947374;8:1825201-24533193;8:6961184-12157391;8:6999220-11895232;8:6999220-11898980;8:6999220-38553064;8:6999220-8881836;8:7053187-11805960;8:7169491-12404062;8:7268820-12039974;8:7691902-12039974 0.40;0.40;4.94;1.92;4.96;4.23;0.40;3.83;7.35;6.09;0.40;4.44;0.40;3.36;1.25;4.99;0.40;4.50;5.93;4.72;4.71;0.40;3.66;1.71;1.55;7.62;1.35;0.40;0.40;3.37;2.63;2.55;7.71;0.40;2.40;1.90;4.25;2.57;11.24;11.93;11.92;1.85;31.03;12.29;11.16;10.16;1.42 dbVar:nssv15168702;dbVar:nssv15169206;dbVar:nssv17956019;dbVar:nssv15154581;dbVar:nssv15149861;dbVar:nssv15775686;dbVar:nssv16208166;dbVar:nssv15774257;dbVar:nssv15149509;dbVar:nssv16216869;dbVar:nssv15169209;dbVar:nssv15223191;dbVar:nssv15147275;dbVar:nssv15148964;dbVar:nssv15147296;dbVar:nssv15146181;nssv15146816;dbVar:nssv15606064;dbVar:nssv15146660;dbVar:nssv15161264;nssv15161582;dbVar:nssv15145917;dbVar:nssv15161283;dbVar:nssv15161284;dbVar:nssv15161070;dbVar:nssv15141976;dbVar:nssv15161050 8:10214-10197718;8:10214-8948469;8:10502-7214947;8:158049-10939681;8:158049-13309069;8:158049-14214722;8:158049-9025197;8:158049-9393052;8:158049-9749574;8:161517-11516619;8:164985-10007227;8:176815-7753583;8:191531-10049105;8:191531-10315994;8:191531-10724642;8:191531-7752586;8:194618-7787444;8:360370-7334625;8:2292236-27361796;8:3791728-11384448;8:7053187-12241152;8:7092360-12372324;8:7169491-12404062;8:7268820-11805960;8:7268820-11819316 5.73;6.53;0.63;5.42;4.44;4.16;6.59;6.32;6.09;5.14;5.93;7.71;5.93;5.77;5.55;7.71;7.69;2.37;2.33;7.69;11.26;11.06;11.16;10.68;10.65 DDD:26674;TS40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2237 8:7283000-7289250 gnomAD-SV_v2.1_DUP_8_23698;8:7374000-7380000 gnomAD-SV_v2.1_DUP_8_23700;8:7570000-7579000 gnomAD-SV_v2.1_DUP_8_23703;8:7684675-7691000 gnomAD-SV_v2.1_DUP_8_23706;8:7737000-7743100 TS40:ISCA-46381;8:7170611-7177489 nsv515099;8:7212583-7227421 1000g;8:7212583-7227421 TS40:ISCA-46631;8:7671000-7687000 gnomAD-SV_v2.1_DUP_8_23705;8:7734213-7856702 DDD:26743;8:7154889-7213289 DDD:26682;8:7632945-7856630 DDD:26727;8:7718891-7784263 DDD:26742;8:7024892-8031414 DDD:26674;8:7053187-8130689 TS40:ISCA-37472;8:7241528-7403182 nsv515100;8:7273500-7474150 gnomAD-SV_v2.1_DUP_8_23697;8:6959834-8600711 esv2764098;8:7283000-7289250 gnomAD-SV_v2.1_DUP_8_23698;8:7374000-7380000 gnomAD-SV_v2.1_DUP_8_23700;8:7570000-7579000 gnomAD-SV_v2.1_DUP_8_23703... 8:7190891-7190961 DDD:26685;8:7308244-7308706 DDD:26704;8:7393000-7403950 gnomAD-SV_v2.1_DUP_8_23701;8:7671000-7682600 gnomAD-SV_v2.1_DUP_8_23704;8:7717878-7717938 DDD:26737;8:7737000-7743100 gnomAD-SV_v2.1_DUP_8_23708;8:7212583-7227421 1000g;8:7212583-7227421 1000g;8:7212583-7227421 dgv1365e214;8:7714000-7724000 gnomAD-SV_v2.1_DUP_8_23707;8:6985776-7230992 DDD:26670;8:7401394-7472190 DDD:26720;8:7634705-7829839 DDD:26729;8:6858816-8072303 esv2761169;8:7035907-7428513 DDD:26675;8:7201176-7392220 DDD:26689;8:7250369-7832042 dgv6936n100;8:7335400-7408600 gnomAD-SV_v2.1_DUP_8_23699;8:7190891-7190961 DDD:26685;8:7308244-7308706 DDD:26704;8:7393000-7403950 gnomAD-SV_v2.1_DUP_8_23701... 8:7175745-7175870 gnomAD-SV_v2.1_DEL_8_89330;8:7179583-7191032 esv3616115;8:7190891-7190961 DDD:26685;8:7204184-7204308 gnomAD-SV_v2.1_DEL_8_89333;8:7228000-7235000 gnomAD-SV_v2.1_DEL_8_89335;8:7326402-7326559 gnomAD-SV_v2.1_DEL_8_89338;8:7429804-7430169 CMRI:4_pbsv.DEL.377_duplicate4;8:7437453-7437818 CMRI:4_pbsv.DEL.378_duplicate3;8:7524674-7530975 gnomAD-SV_v2.1_DEL_8_89347;8:7544000-7550200 gnomAD-SV_v2.1_DEL_8_89349;8:7717878-7717938 DDD:26737;8:7158202-7189800 DDD:26683;8:7190892-7196288 DDD:26687;8:7212583-7227421 esv3616116;8:7355294-7364762 1000g;8:7402900-7419700 gnomAD-SV_v2.1_DEL_8_89341;8:7417000-7425000 gnomAD-SV_v2.1_DEL_8_89343;8:7547450-7565825 gnomAD-SV_v2.1_DEL_8_89350;8:7736500-7764500 HI40:ISCA-46380;8:7745000-7754100 HI40:ISCA-46382;8:6985776-7230992 DDD:26670... 8:7166200-7171600 gnomAD-SV_v2.1_DEL_8_89328;8:7179583-7191032 1000g;8:7180382-7180743 gnomAD-SV_v2.1_DEL_8_89331;8:7201000-7206400 gnomAD-SV_v2.1_DEL_8_89332;8:7223698-7223747 CMRI:0_pbsv.DEL.273_duplicate4;8:7308244-7308706 DDD:26704;8:7422159-7422524 CMRI:20_pbsv.DEL.359_duplicate4;8:7435323-7437158 CMRI:29_pbsv.DEL.464_duplicate4;8:7443400-7452400 gnomAD-SV_v2.1_DEL_8_89344;8:7537821-7544002 gnomAD-SV_v2.1_DEL_8_89348;8:7553200-7562800 gnomAD-SV_v2.1_DEL_8_89351;8:7158046-7189992 esv2675221;8:7168000-7181000 gnomAD-SV_v2.1_DEL_8_89329;8:7212583-7227421 1000g;8:7355000-7363000 gnomAD-SV_v2.1_DEL_8_89340;8:7355294-7364762 esv3616120;8:7405950-7443050 gnomAD-SV_v2.1_DEL_8_89342;8:7447000-7460125 gnomAD-SV_v2.1_DEL_8_89346;8:7567300-7573600 gnomAD-SV_v2.1_DEL_8_89352;8:7736500-7764500 gnomAD-SV_v2.1_DEL_8_89353;8:7745000-7754100 gnomAD-SV_v2.1_DEL_8_89355... 1014876;1018294;1018768;1021421;1021422;1023557;1027037;1027038;1027039;1027040;1027041;133705;133738;133739;133740;14765;14786;14796;14797;14800;14802;14805;1520679;1697091;1862942;1915732;1927149;2200010;2599287;3052323;362503;362536;362537;362539;362541;362544;362549;362552;480936;481105;481113;481152;481153;481161;481163;481165;556230;556321;556330;556334;556336;... gain;loss 0.260 0.330 8:7150797-7184572;8:7150797-7195814;8:7150797-7200543;8:7150798-7238459 8:7600001-7825413 8:7012601-8066200 High Signal Region 8:7012601-8066200 High Signal Region 99.72 2.14121257165536 2.19863945242443 8 4.2180e-01 5.1947e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (23 genes, +0.00);5F (+0.00) 1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB103A NM_001081551 7286415 7287682 1267 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7286415 7287682 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23698;nsv515100 8:7283000-7289250;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 93.4 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB103B NM_018661 7286415 7287870 1455 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7286415 7287870 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23698;nsv515100 8:7283000-7289250;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 85.97 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB104A NM_080389 7327829 7332639 4810 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7327829 7332639 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 96.98 1.33624136747443 2.19863945242443 9 9.3748e-02 5.1947e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB104B NM_001040702 7327829 7332604 4775 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7327829 7332604 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 95.66 9 3.3176e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB105A NM_152250 7345190 7347115 1925 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7345190 7347115 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 90.61 0.918523398770926 0.00809335391872301 8 3.7719e-01 4.3625e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB105B NM_001040703 7345200 7347115 1915 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7345200 7347115 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 90.95 9 2.9184e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB106A NM_152251 7340025 7343942 3917 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7340025 7343942 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 90.45 0.676417083229402 1.6332400949348 9 8.5821e-03 4.0931e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB106B NM_001040704 7340025 7343909 3884 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7340025 7343909 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 93.29 9 8.1151e-02 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB107A NM_001037668 7353367 7366833 13466 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7353367 7366833 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 603719;849088;921364 gain 92.48 9 3.2633e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB107B NM_001040705 7353432 7366833 13401 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7353432 7366833 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 603719;849088;921364 gain 91.71 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB109B NM_001037380 7170367 7177473 7106 264 100 no 2 txStart-txEnd 5'UTR-3'UTR 7170367 7177473 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26683;HI40:ISCA-37472;esv2675221;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89329 8:7158046-7189992;8:7158202-7189800;8:7168000-7181000;8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.3826 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB4A NM_004942 7752198 7754238 1385 58 29 yes 2 txStart-intron1 5'UTR-CDS 412 3' 7752198 7753583 DDD:26674;DDD:26727;DDD:26729;DDD:26742;DDD:26743;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098 8:7734213-7856702;8:7632945-7856630;8:7634705-7829839;8:7718891-7784263;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;HI40:ISCA-46380;HI40:ISCA-46382;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89353;gnomAD-SV_v2.1_DEL_8_89355 8:7736500-7764500;8:7736500-7764500;8:7745000-7754100;8:7745000-7754100;8:7632945-7856630;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.5182 97.87 1.12959151611996 0.758429673080804 9 1.1637e-03 3.9981e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB4B NM_001205266 7272384 7274354 1970 195 100 no 2 txStart-txEnd 5'UTR-3'UTR 7272384 7274354 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 99.72 9 6.7977e-02 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM66B NR_027423 7156265 7212885 43395 0 0 no 7 txStart-intron6 UTR 9797 3' 7169490 7212885 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A10P NR_046351 7627105 7628835 1730 0 0 no 3 txStart-txEnd UTR 7627105 7628835 DDD:26674;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A7P NR_046343 7421309 7431920 10611 0 0 no 3 txStart-txEnd UTR 7421309 7431920 DDD:26674;DDD:26720;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 8:7401394-7472190;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26720;HI40:ISCA-37472;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89342 8:7405950-7443050;8:7401394-7472190;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.4842 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 PRR23D1 NM_001282479 7397148 7399972 2824 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7397148 7399972 DDD:26674;DDD:26675;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;gnomAD-SV_v2.1_DUP_8_23701;nsv515100 8:7393000-7403950;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.5625 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 8 4.2180e-01 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 PRR23D2 NM_001282478 7397149 7399972 2823 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7397149 7399972 DDD:26674;DDD:26675;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;gnomAD-SV_v2.1_DUP_8_23701;nsv515100 8:7393000-7403950;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.5625 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 SPAG11A NM_001081552 7705529 7721319 15790 327 100 no 4 txStart-txEnd 5'UTR-3'UTR 7705529 7721319 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098 8:7632945-7856630;8:7634705-7829839;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:7632945-7856630;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2237 97.15 0.140072348156658 0.903069021299127 9 6.9645e-05 3.9012e-02 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 SPAG11B NM_058201 7308085 7321192 13107 402 100 no 3 txStart-txEnd 5'UTR-3'UTR 7308085 7321192 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 89.4 2.14121257165536 1.8677219993927 9 2.7751e-02 4.7238e-02 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 USP17L1 NM_001256873 7189908 7191501 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7189908 7191501 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 USP17L4 NM_001256874 7194636 7196229 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7194636 7196229 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26687;HI40:ISCA-37472;esv2761169;esv2764098 8:7190892-7196288;8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 ZNF705G NM_001164457 7213038 7243080 30042 903 100 no 7 txStart-txEnd 5'UTR-3'UTR 7213038 7243080 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 1023557;654991;676140;732002;745967;745968 gain;loss 91.1 -1.59751875296103 -3.97736276921453 9 1.6471e-08 4.2486e-09 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA full p23.1 DEFB103A;DEFB103B;DEFB104A;DEFB104B;DEFB105A;DEFB105B;DEFB106A;DEFB106B;DEFB107A;DEFB107B;DEFB109B;DEFB4A;DEFB4B;FAM66B;FAM90A10P;FAM90A7P;PRR23D1;PRR23D2;SPAG11A;SPAG11B;USP17L1;USP17L4;ZNF705G 23 MCPH1 (morbid/RE=GH_Promoter/Enhancer) dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161508;dbVar:nssv15161747;dbVar:nssv17957391;dbVar:nssv15154583;dbVar:nssv15161801;nssv15777239;dbVar:nssv15154584;dbVar:nssv16206921;dbVar:nssv15154580;dbVar:nssv15161417;nssv15161657;dbVar:nssv15147671;dbVar:nssv15161846;dbVar:nssv15150473;dbVar:nssv15127651;dbVar:nssv15149098;dbVar:nssv15169210;dbVar:nssv15154582;dbVar:nssv15146537;dbVar:nssv15161807;dbVar:nssv15161553;dbVar:nssv15161105;dbVar:nssv15161095;dbVar:nssv15161561;dbVar:nssv15161078;dbVar:nssv15147455;dbVar:nssv16736635;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161749;dbVar:nssv15143576;dbVar:nssv15161775;dbVar:nssv15146180;dbVar:nssv15161087;dbVar:nssv15161068;dbVar:nssv15161792;dbVar:nssv15606063;dbVar:nssv15151542;dbVar:nssv15161084;dbVar:nssv16206931;dbVar:nssv15154577;dbVar:nssv15161089;dbVar:nssv15151538;dbVar:nssv15152254;dbVar:nssv15161540;dbVar:nssv15161727;dbVar:nssv15161764 8:10214-146293414;8:13939-146304022;8:46311-11879315;8:46311-30472220;8:158049-11936107;8:158049-13974319;8:158049-146295771;8:158049-15423270;8:158049-8102819;8:158049-9750676;8:158050-146295771;8:158992-13304906;8:158992-146280828;8:158992-17536147;8:163683-46938942;8:164985-11860845;8:164985-146293414;8:168484-13147575;8:169854-10022996;8:176453-12556063;8:176453-12570496;8:176453-146294098;8:176453-16137655;8:176453-34349408;8:176453-37879246;8:176453-7838959;8:176815-43396776;8:191531-146274835;8:191531-146280020;8:191531-17536206;8:191531-22404983;8:191531-23055911;8:191531-7752586;8:191606-146280167;8:191606-24514484;8:191606-30948590;8:194618-13947374;8:1825201-24533193;8:6961184-12157391;8:6999220-11895232;8:6999220-11898980;8:6999220-38553064;8:6999220-8881836;8:7053187-11805960;8:7169491-12404062;8:7268820-12039974;8:7691902-12039974 0.40;0.40;4.94;1.92;4.96;4.23;0.40;3.83;7.35;6.09;0.40;4.44;0.40;3.36;1.25;4.99;0.40;4.50;5.93;4.72;4.71;0.40;3.66;1.71;1.55;7.62;1.35;0.40;0.40;3.37;2.63;2.55;7.71;0.40;2.40;1.90;4.25;2.57;11.24;11.93;11.92;1.85;31.03;12.29;11.16;10.16;1.42 dbVar:nssv15168702;dbVar:nssv15169206;dbVar:nssv17956019;dbVar:nssv15154581;dbVar:nssv15149861;dbVar:nssv15775686;dbVar:nssv16208166;dbVar:nssv15774257;dbVar:nssv15149509;dbVar:nssv16216869;dbVar:nssv15169209;dbVar:nssv15223191;dbVar:nssv15147275;dbVar:nssv15148964;dbVar:nssv15147296;dbVar:nssv15146181;nssv15146816;dbVar:nssv15606064;dbVar:nssv15146660;dbVar:nssv15161264;nssv15161582;dbVar:nssv15145917;dbVar:nssv15161283;dbVar:nssv15161284;dbVar:nssv15161070;dbVar:nssv15141976;dbVar:nssv15161050 8:10214-10197718;8:10214-8948469;8:10502-7214947;8:158049-10939681;8:158049-13309069;8:158049-14214722;8:158049-9025197;8:158049-9393052;8:158049-9749574;8:161517-11516619;8:164985-10007227;8:176815-7753583;8:191531-10049105;8:191531-10315994;8:191531-10724642;8:191531-7752586;8:194618-7787444;8:360370-7334625;8:2292236-27361796;8:3791728-11384448;8:7053187-12241152;8:7092360-12372324;8:7169491-12404062;8:7268820-11805960;8:7268820-11819316 5.73;6.53;0.63;5.42;4.44;4.16;6.59;6.32;6.09;5.14;5.93;7.71;5.93;5.77;5.55;7.71;7.69;2.37;2.33;7.69;11.26;11.06;11.16;10.68;10.65 DDD:26674;TS40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2237 8:7283000-7289250 gnomAD-SV_v2.1_DUP_8_23698;8:7374000-7380000 gnomAD-SV_v2.1_DUP_8_23700;8:7570000-7579000 gnomAD-SV_v2.1_DUP_8_23703;8:7684675-7691000 gnomAD-SV_v2.1_DUP_8_23706;8:7737000-7743100 TS40:ISCA-46381;8:7170611-7177489 nsv515099;8:7212583-7227421 1000g;8:7212583-7227421 TS40:ISCA-46631;8:7671000-7687000 gnomAD-SV_v2.1_DUP_8_23705;8:7734213-7856702 DDD:26743;8:7154889-7213289 DDD:26682;8:7632945-7856630 DDD:26727;8:7718891-7784263 DDD:26742;8:7024892-8031414 DDD:26674;8:7053187-8130689 TS40:ISCA-37472;8:7241528-7403182 nsv515100;8:7273500-7474150 gnomAD-SV_v2.1_DUP_8_23697;8:6959834-8600711 esv2764098;8:7283000-7289250 gnomAD-SV_v2.1_DUP_8_23698;8:7374000-7380000 gnomAD-SV_v2.1_DUP_8_23700;8:7570000-7579000 gnomAD-SV_v2.1_DUP_8_23703... 8:7190891-7190961 DDD:26685;8:7308244-7308706 DDD:26704;8:7393000-7403950 gnomAD-SV_v2.1_DUP_8_23701;8:7671000-7682600 gnomAD-SV_v2.1_DUP_8_23704;8:7717878-7717938 DDD:26737;8:7737000-7743100 gnomAD-SV_v2.1_DUP_8_23708;8:7212583-7227421 1000g;8:7212583-7227421 1000g;8:7212583-7227421 dgv1365e214;8:7714000-7724000 gnomAD-SV_v2.1_DUP_8_23707;8:6985776-7230992 DDD:26670;8:7401394-7472190 DDD:26720;8:7634705-7829839 DDD:26729;8:6858816-8072303 esv2761169;8:7035907-7428513 DDD:26675;8:7201176-7392220 DDD:26689;8:7250369-7832042 dgv6936n100;8:7335400-7408600 gnomAD-SV_v2.1_DUP_8_23699;8:7190891-7190961 DDD:26685;8:7308244-7308706 DDD:26704;8:7393000-7403950 gnomAD-SV_v2.1_DUP_8_23701... 8:7175745-7175870 gnomAD-SV_v2.1_DEL_8_89330;8:7179583-7191032 esv3616115;8:7190891-7190961 DDD:26685;8:7204184-7204308 gnomAD-SV_v2.1_DEL_8_89333;8:7228000-7235000 gnomAD-SV_v2.1_DEL_8_89335;8:7326402-7326559 gnomAD-SV_v2.1_DEL_8_89338;8:7429804-7430169 CMRI:4_pbsv.DEL.377_duplicate4;8:7437453-7437818 CMRI:4_pbsv.DEL.378_duplicate3;8:7524674-7530975 gnomAD-SV_v2.1_DEL_8_89347;8:7544000-7550200 gnomAD-SV_v2.1_DEL_8_89349;8:7717878-7717938 DDD:26737;8:7158202-7189800 DDD:26683;8:7190892-7196288 DDD:26687;8:7212583-7227421 esv3616116;8:7355294-7364762 1000g;8:7402900-7419700 gnomAD-SV_v2.1_DEL_8_89341;8:7417000-7425000 gnomAD-SV_v2.1_DEL_8_89343;8:7547450-7565825 gnomAD-SV_v2.1_DEL_8_89350;8:7736500-7764500 HI40:ISCA-46380;8:7745000-7754100 HI40:ISCA-46382;8:6985776-7230992 DDD:26670... 8:7166200-7171600 gnomAD-SV_v2.1_DEL_8_89328;8:7179583-7191032 1000g;8:7180382-7180743 gnomAD-SV_v2.1_DEL_8_89331;8:7201000-7206400 gnomAD-SV_v2.1_DEL_8_89332;8:7223698-7223747 CMRI:0_pbsv.DEL.273_duplicate4;8:7308244-7308706 DDD:26704;8:7422159-7422524 CMRI:20_pbsv.DEL.359_duplicate4;8:7435323-7437158 CMRI:29_pbsv.DEL.464_duplicate4;8:7443400-7452400 gnomAD-SV_v2.1_DEL_8_89344;8:7537821-7544002 gnomAD-SV_v2.1_DEL_8_89348;8:7553200-7562800 gnomAD-SV_v2.1_DEL_8_89351;8:7158046-7189992 esv2675221;8:7168000-7181000 gnomAD-SV_v2.1_DEL_8_89329;8:7212583-7227421 1000g;8:7355000-7363000 gnomAD-SV_v2.1_DEL_8_89340;8:7355294-7364762 esv3616120;8:7405950-7443050 gnomAD-SV_v2.1_DEL_8_89342;8:7447000-7460125 gnomAD-SV_v2.1_DEL_8_89346;8:7567300-7573600 gnomAD-SV_v2.1_DEL_8_89352;8:7736500-7764500 gnomAD-SV_v2.1_DEL_8_89353;8:7745000-7754100 gnomAD-SV_v2.1_DEL_8_89355... 1014876;1018294;1018768;1021421;1021422;1023557;1027037;1027038;1027039;1027040;1027041;133705;133738;133739;133740;14765;14786;14796;14797;14800;14802;14805;1520679;1697091;1862942;1915732;1927149;2200010;2599287;3052323;362503;362536;362537;362539;362541;362544;362549;362552;480936;481105;481113;481152;481153;481161;481163;481165;556230;556321;556330;556334;556336;... gain;loss 0.260 0.330 8:7150797-7184572;8:7150797-7195814;8:7150797-7200543;8:7150798-7238459 8:7600001-7825413 8:7012601-8066200 High Signal Region 8:7012601-8066200 High Signal Region 99.72 2.14121257165536 2.19863945242443 8 4.2180e-01 5.1947e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2L (DEFB4A/FAM66B, +0.00);3A (23 genes, +0.00);5F (+0.00) 1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB103A NM_001081551 7286415 7287682 1267 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7286415 7287682 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23698;nsv515100 8:7283000-7289250;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 93.4 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB103B NM_018661 7286415 7287870 1455 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7286415 7287870 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23698;nsv515100 8:7283000-7289250;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 85.97 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB104A NM_080389 7327829 7332639 4810 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7327829 7332639 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 96.98 1.33624136747443 2.19863945242443 9 9.3748e-02 5.1947e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB104B NM_001040702 7327829 7332604 4775 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7327829 7332604 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 95.66 9 3.3176e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB105A NM_152250 7345190 7347115 1925 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7345190 7347115 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 90.61 0.918523398770926 0.00809335391872301 8 3.7719e-01 4.3625e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB105B NM_001040703 7345200 7347115 1915 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7345200 7347115 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 90.95 9 2.9184e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB106A NM_152251 7340025 7343942 3917 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7340025 7343942 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 90.45 0.676417083229402 1.6332400949348 9 8.5821e-03 4.0931e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB106B NM_001040704 7340025 7343909 3884 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7340025 7343909 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 93.29 9 8.1151e-02 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB107A NM_001037668 7353367 7366833 13466 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7353367 7366833 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 603719;849088;921364 gain 92.48 9 3.2633e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB107B NM_001040705 7353432 7366833 13401 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7353432 7366833 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 603719;849088;921364 gain 91.71 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB109B NM_001037380 7170367 7177473 7106 264 100 no 2 txStart-txEnd 5'UTR-3'UTR 7170367 7177473 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26683;HI40:ISCA-37472;esv2675221;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89329 8:7158046-7189992;8:7158202-7189800;8:7168000-7181000;8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.3826 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB4A NM_004942 7752198 7754238 1385 58 29 yes 2 txStart-intron1 5'UTR-CDS 412 3' 7752198 7753583 DDD:26674;DDD:26727;DDD:26729;DDD:26742;DDD:26743;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098 8:7734213-7856702;8:7632945-7856630;8:7634705-7829839;8:7718891-7784263;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;HI40:ISCA-46380;HI40:ISCA-46382;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89353;gnomAD-SV_v2.1_DEL_8_89355 8:7736500-7764500;8:7736500-7764500;8:7745000-7754100;8:7745000-7754100;8:7632945-7856630;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.5182 97.87 1.12959151611996 0.758429673080804 9 1.1637e-03 3.9981e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB4B NM_001205266 7272384 7274354 1970 195 100 no 2 txStart-txEnd 5'UTR-3'UTR 7272384 7274354 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 99.72 9 6.7977e-02 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM66B NR_027423 7156265 7212885 43395 0 0 no 7 txStart-intron6 UTR 9797 3' 7169490 7212885 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A10P NR_046351 7627105 7628835 1730 0 0 no 3 txStart-txEnd UTR 7627105 7628835 DDD:26674;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A7P NR_046343 7421309 7431920 10611 0 0 no 3 txStart-txEnd UTR 7421309 7431920 DDD:26674;DDD:26720;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 8:7401394-7472190;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26720;HI40:ISCA-37472;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89342 8:7405950-7443050;8:7401394-7472190;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.4842 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 PRR23D1 NM_001282479 7397148 7399972 2824 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7397148 7399972 DDD:26674;DDD:26675;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;gnomAD-SV_v2.1_DUP_8_23701;nsv515100 8:7393000-7403950;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.5625 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 8 4.2180e-01 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 PRR23D2 NM_001282478 7397149 7399972 2823 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7397149 7399972 DDD:26674;DDD:26675;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;gnomAD-SV_v2.1_DUP_8_23701;nsv515100 8:7393000-7403950;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;8:6959834-8600711 0.5625 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 SPAG11A NM_001081552 7705529 7721319 15790 327 100 no 4 txStart-txEnd 5'UTR-3'UTR 7705529 7721319 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098 8:7632945-7856630;8:7634705-7829839;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;8:6959834-8600711 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:7632945-7856630;8:6858816-8072303;8:7024892-8031414;8:7053187-8130689;8:6959834-8600711 0.2237 97.15 0.140072348156658 0.903069021299127 9 6.9645e-05 3.9012e-02 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 SPAG11B NM_058201 7308085 7321192 13107 402 100 no 3 txStart-txEnd 5'UTR-3'UTR 7308085 7321192 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 89.4 2.14121257165536 1.8677219993927 9 2.7751e-02 4.7238e-02 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 USP17L1 NM_001256873 7189908 7191501 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7189908 7191501 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 USP17L4 NM_001256874 7194636 7196229 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7194636 7196229 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;esv2761169;esv2764098 8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26687;HI40:ISCA-37472;esv2761169;esv2764098 8:7190892-7196288;8:6985776-7230992;8:7154889-7213289;8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 full=1 -8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 ZNF705G NM_001164457 7213038 7243080 30042 903 100 no 7 txStart-txEnd 5'UTR-3'UTR 7213038 7243080 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7201176-7392220;8:6959834-8600711 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:6959834-8600711 0.2237 1023557;654991;676140;732002;745967;745968 gain;loss 91.1 -1.59751875296103 -3.97736276921453 9 1.6471e-08 4.2486e-09 full=1 -14_107152093_107180095_DEL_1 14 107152093 107180095 -28002 DEL Benign NA full q32.33 0 dbVar:nssv15162475;dbVar:nssv15161908;dbVar:nssv15162476;dbVar:nssv15161629;dbVar:nssv15161107;nssv15161424;dbVar:nssv15161067;dbVar:nssv15161689;dbVar:nssv15161760;dbVar:nssv15161081;dbVar:nssv15161039;dbVar:nssv15161040;dbVar:nssv15777241;dbVar:nssv15125898;dbVar:nssv15161535;dbVar:nssv15777234;dbVar:nssv15161537;dbVar:nssv15606082;dbVar:nssv15161360;dbVar:nssv15135151 14:19000423-107289053;14:19280734-107287663;14:19327824-107287663;14:19794562-107234280;14:20511674-107285437;14:20619309-107263478;14:73750742-107285437;14:74122476-107287505;14:77689139-107287505;14:86560375-107240869;14:91922206-107240869;14:91969029-107285437;14:93331785-107289540;14:98104858-107263478;14:99794231-107285437;14:99914350-107258824;14:100575918-107281934;14:103788752-107263478;14:106252706-107263478 0.03;0.03;0.03;0.03;0.03;0.03;0.08;0.08;0.09;0.14;0.18;0.18;0.20;0.31;0.37;0.38;0.42;0.81;2.77 dbVar:nssv15161324;dbVar:nssv16215328;dbVar:nssv15161030;dbVar:nssv15161062;dbVar:nssv15142554;dbVar:nssv15161267;dbVar:nssv15161579;dbVar:nssv15161268;dbVar:nssv17968992;dbVar:nssv15161102;dbVar:nssv15161557;dbVar:nssv16255573;dbVar:nssv15142555;dbVar:nssv15161354;dbVar:nssv15777252;dbVar:nssv15161369;dbVar:nssv15141232;nssv16208943;dbVar:nssv15150359;dbVar:nssv15161271;dbVar:nssv15161574;dbVar:nssv15161803;dbVar:nssv16208399;dbVar:nssv15142293;dbVar:nssv16208400;dbVar:nssv15120383;dbVar:nssv15137946 14:95990745-107287708;14:96829291-107287663;14:98404975-107263478;14:100297993-107263478;14:100661320-107285437;14:100775720-107263478;14:101048397-107285437;14:101274638-107263478;14:101732159-107285437;14:102131940-107263478;14:102392008-107284531;14:102615954-107285437;14:102670707-107285437;14:102705760-107285437;14:102931120-107285437;14:103071434-107287505;14:103153638-107285437;14:103965060-107285437;14:104251096-107278770;14:104289938-107287505;14:104517596-107285437;14:104764079-107285437;14:104915609-107285437;14:105303585-107285437;14:105489734-107258965;14:106252706-107287505 0.25;0.27;0.32;0.40;0.42;0.43;0.45;0.47;0.50;0.55;0.57;0.60;0.61;0.61;0.64;0.66;0.68;0.84;0.92;0.93;1.01;1.11;1.18;1.41;1.58;2.71 DDD:43963;TS40:ISCA-37477;esv2760346 14:107136632-107191499;14:106050001-107289540;14:106437088-107285437 0.0828 DDD:43904;DDD:43963;HI40:ISCA-37477;esv2760346 14:107136632-107191499;14:106050001-107289540;14:106437088-107285437;14:106700994-107266403 0.2438 14:107145552-107179808 dgv699e212;14:107147167-107164532 dgv428e214;14:106437088-107285437 esv2760346 14:107136632-107191499 DDD:43963;14:107147167-107164532 TS40:ISCA-46684;14:106050001-107289540 TS40:ISCA-37477 14:107172849-107183396 esv3635707;14:107174399-107174927 DDD:43974;14:107171544-107171645 CMRI:8_pbsv.DEL.1461_duplicate6;14:107054315-107166266 DDD:43951;14:106437088-107285437 esv2760346; 14:107172849-107183396 HI40:ISCA-46673;14:107174391-107174931 esv3635708;14:107174399-107174927 esv2665347;14:107136632-107191499 DDD:43963;14:106050001-107289540 HI40:ISCA-37477;14:106700994-107266403 DDD:43904 0.355 0.425 14:107151001-107176900 High Signal Region -1.6 1B (cf Gene_count, RE_gene, -0.60);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (0 gene, +0.00);5F (+0.00) 1 -6_78979173_79023328_DEL_1 6 78979173 79023328 -44155 DEL Benign NA full q14.1 0 dbVar:nssv15166690;dbVar:nssv15166692;dbVar:nssv15161859;nssv15161868;dbVar:nssv15168255;dbVar:nssv15606075;dbVar:nssv17970109;dbVar:nssv15148895 6:60108-171054786;6:108667-170980171;6:156976-170919482;6:165633-170919470;6:29455466-81447367;6:69938253-94379210;6:75092524-142361637 0.03;0.03;0.03;0.03;0.08;0.18;0.07 dbVar:nssv15138420;dbVar:nssv17957115;dbVar:nssv17956905;dbVar:nssv15154430;dbVar:nssv16255333;dbVar:nssv15139907;dbVar:nssv16215036 6:65259549-84136510;6:70165297-79920769;6:72799055-83275894;6:73674613-84829774;6:74226560-80208037;6:76635917-93420511;6:78562076-79746800 0.23;0.45;0.42;0.40;0.74;0.26;3.73 DDD:21366;dgv768n27;nsv516597 6:78973202-79031742;6:78848098-79052702;6:78950789-79066065 0.3704 1000g;CMRI:4_pbsv.DEL.1666_duplicate2;DDD:21366;DDD:21369;DDD:21373;dgv10802n54;dgv1137e199;dgv1810e212;dgv1811e212;dgv6030n100;dgv6037n100;dgv766n27;dgv767n27;dgv769n27;esv2422170;esv2760997;esv2763987;esv3609657;esv3609663;esv3890888;gnomAD-SV_v2.1_DEL_6_70839;nsv514376;nsv516597 6:78962541-79031742;6:78962582-79027502;6:78965526-79033478;6:78967098-79036275;6:78967098-79036275;6:78969054-79027758;6:78969066-79031970;6:78969066-79035185;6:78972098-79031153;6:78972931-79033478;6:78973202-79031742;6:78836835-79051952;6:78848098-79052702;6:78892809-79053430;6:78892809-79053430;6:78950789-79066065;6:78961945-79041809;6:78962294-79041760;6:78962541-79052702;6:78962582-79041797;6:78967187-79036419;6:78967195-79036475;6:78967195-79036497;6:78967214-79036472 0.4631 6:78973202-79031742 dgv768n27;6:78848098-79052702 nsv516597; 6:78963972-78992918 DDD:21367;6:78999918-79033124 DDD:21375;6:78950789-79066065 DDD:21366 6:78962582-79027502 dgv1811e212;6:78967098-79036275 1000g;6:78969054-79027758 dgv6037n100;6:78969066-79035185 esv2422170;6:78972931-79033478 dgv10802n54;6:78836835-79051952 esv2760997;6:78892809-79053430 1000g;6:78950789-79066065 DDD:21366;6:78962294-79041760 dgv1810e212;6:78962582-79041797 dgv6030n100;6:78967195-79036475 DDD:21369;6:78967214-79036472 CMRI:4_pbsv.DEL.1666_duplicate2 6:78962541-79031742 dgv766n27;6:78965526-79033478 esv3890888;6:78967098-79036275 esv3609663;6:78969066-79031970 DDD:21373;6:78972098-79031153 nsv514376;6:78973202-79031742 dgv769n27;6:78848098-79052702 nsv516597;6:78892809-79053430 esv3609657;6:78961945-79041809 esv2763987;6:78962541-79052702 dgv767n27;6:78967187-79036419 gnomAD-SV_v2.1_DEL_6_70839;6:78967195-79036497 dgv1137e199 0.325 0.270 -1.6 1B (cf Gene_count, RE_gene, -0.60);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (0 gene, +0.00);5F (+0.00) 1 +AnnotSV_ID SV_chrom SV_start SV_end SV_length SV_type Biologist_annotation Biologist_ranking Samples_ID Annotation_mode CytoBand Gene_name Closest_left Closest_right Gene_count Tx Tx_version Tx_start Tx_end Overlapped_tx_length Overlapped_CDS_length Overlapped_CDS_percent Frameshift Exon_count Location Location2 Dist_nearest_SS Nearest_SS_type Intersect_start Intersect_end RE_gene P_gain_phen P_gain_hpo P_gain_source P_gain_coord P_loss_phen P_loss_hpo P_loss_source P_loss_coord P_ins_phen P_ins_hpo P_ins_source P_ins_coord po_P_gain_phen po_P_gain_hpo po_P_gain_source po_P_gain_coord po_P_gain_percent po_P_loss_phen po_P_loss_hpo po_P_loss_source po_P_loss_coord po_P_loss_percent P_snvindel_nb P_snvindel_phen B_gain_source B_gain_coord B_gain_AFmax B_loss_source B_loss_coord B_loss_AFmax B_ins_source B_ins_coord B_ins_AFmax B_inv_source B_inv_coord B_inv_AFmax po_B_gain_allG_source po_B_gain_allG_coord po_B_gain_someG_source po_B_gain_someG_coord po_B_loss_allG_source po_B_loss_allG_coord po_B_loss_someG_source po_B_loss_someG_coord Cosmic_ID Cosmic_mut_typ GC_content_left GC_content_right Repeat_coord_left Repeat_type_left Repeat_coord_right Repeat_type_right Gap_left Gap_right SegDup_left SegDup_right ENCODE_blacklist_left ENCODE_blacklist_characteristics_left ENCODE_blacklist_right ENCODE_blacklist_characteristics_right ACMG HI TS DDD_HI_percent ExAC_delZ ExAC_dupZ ExAC_cnvZ ExAC_synZ ExAC_misZ GenCC_disease GenCC_moi GenCC_classification GenCC_pmid NCBI_gene_ID OMIM_ID OMIM_phenotype OMIM_inheritance OMIM_morbid OMIM_morbid_candidate LOEUF_bin GnomAD_pLI ExAC_pLI AnnotSV_ranking_score AnnotSV_ranking_criteria ACMG_class +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA full q11.21 DGCR6;PRODH;LOC122455341;DGCR5;FAM246C;DGCR2;DGCR11;ESS2;TSSK2;GSC2;LINC01311;SLC25A1;CLTCL1;HIRA;MRPL40;C22orf39;UFD1;CDC45;CLDN5;LINC00895;SEPTIN5;SEPT5-GP1BB;GP1BB;TBX1;GNB1L;RTL10;TXNRD2;COMT;MIR4761;ARVCF;TANGO2;MIR185;DGCR8;MIR3618;MIR1306;TRMT2A;MIR6816;RANBP1;SNORA77B;ZDHHC8;CCDC188;LINC02891;LINC00896;RTN4R;MIR1286;DGCR6L;FAM230A;GGTLC3;TMEM191B;PI4KAP1;RIMBP3;FAM246B;FAM230J;FAM230G;ZNF74;SCARF2;KLHL22;MED15;POM121L4P;TMEM191A;PI4KA;SERPIND1;SNAP29;CRKL;LINC01637;AIFM3;LZTR1;THAP7;THAP7-AS1;TUBA3FP;P2RX6;SLC7A4;MIR649;P2RX6P;LRRC74B;BCRP2 FAM230F LOC102724728 76 ABL1 (morbid/RE=mTL_miRNA);ACTN4 (morbid/RE=mTL_miRNA);ACVR2B (morbid/RE=mTL_miRNA);ADA2 (morbid/RE=ABC_enhancer);ADAR (morbid/RE=mTL_miRNA);ADH5 (morbid/RE=mTL_miRNA);AFF2 (HI=3/morbid/RE=mTL_miRNA);AGO1 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AHI1 (morbid/RE=mTL_miRNA);AKT1 (morbid/RE=mTL_miRNA);ALG1 (morbid/RE=mTL_miRNA);AMH (morbid/RE=mTL_miRNA);APCDD1 (morbid/RE=mTL_miRNA);AR (HI=3/morbid/RE=mTL_miRNA);ARID1A (HI=3/morbid/RE=mTL_miRNA);ASH1L (HI=3/morbid/RE=mTL_miRNA);ATM (HI=3/morbid/RE=mTL_miRNA);ATP6AP1 (morbid/RE=mTL_miRNA);ATP6V0A2 (morbid/RE=mTL_miRNA);ATP6V1E1 (morbid/RE=ABC_enhancer);ATR (morbid/RE=mTL_miRNA);B4GALT1 (morbid/RE=mTL_miRNA);BACH1 (morbid/RE=mTL_miRNA);BAP1 (HI=3/morbid/RE=mTL_miRNA);BBS5 (morbid/RE=mTL_miRNA);BCL10 (morbid/RE=mTL_miRNA);BMPR1A (HI=3/morbid/RE=mTL_miRNA);BNC2 (morbid/RE=mTL_miRNA);BRD4 (morbid/RE=mTL_miRNA);C3 (morbid/RE=mTL_miRNA);CACNA1C (morbid/RE=mTL_miRNA);CAD (morbid/RE=mTL_miRNA);CALM3 (morbid/RE=mTL_miRNA);CAPN15 (morbid/RE=mTL_miRNA);CASP14 (morbid/RE=mTL_miRNA);CBL (morbid/RE=mTL_miRNA);CCDC134 (morbid/RE=mTL_miRNA);CCND2 (morbid/RE=mTL_miRNA);CCNQ (morbid/RE=mTL_miRNA);CDC42 (morbid/RE=mTL_miRNA);CEP104 (morbid/RE=mTL_miRNA);CERS1 (morbid/RE=mTL_miRNA);CHRDL1 (HI=3/morbid/RE=mTL_miRNA);CLCC1 (morbid/RE=mTL_miRNA);CLCN7 (morbid/RE=mTL_miRNA);CLDN16 (morbid/RE=mTL_miRNA);CLPB (morbid/RE=mTL_miRNA);CNBP (morbid/RE=mTL_miRNA);CNNM4 (morbid/RE=mTL_miRNA);CNOT3 (morbid/RE=mTL_miRNA);CNTNAP2 (morbid/RE=mTL_miRNA);COCH (morbid/RE=mTL_miRNA);COL1A1 (HI=3/morbid/RE=mTL_miRNA);COPB1 (morbid/RE=mTL_miRNA);CWF19L1 (morbid/RE=mTL_miRNA);CYCS (morbid/RE=mTL_miRNA);DDHD1 (morbid/RE=mTL_miRNA);DDX11 (morbid/RE=mTL_miRNA);DGKE (morbid/RE=mTL_miRNA);DIAPH1 (morbid/RE=mTL_miRNA);DLG5 (morbid/RE=mTL_miRNA);DMPK (morbid/RE=mTL_miRNA);DNM2 (morbid/RE=mTL_miRNA);DNMT1 (morbid/RE=mTL_miRNA);DZIP1L (morbid/RE=mTL_miRNA);EDAR (morbid/RE=mTL_miRNA);EIF2S3 (morbid/RE=mTL_miRNA);ELOVL1 (morbid/RE=mTL_miRNA);EMC10 (morbid/RE=mTL_miRNA);ENG (HI=3/morbid/RE=mTL_miRNA);EPAS1 (morbid/RE=mTL_miRNA);EPHA2 (morbid/RE=mTL_miRNA);EZH2 (morbid/RE=mTL_miRNA);F2 (morbid/RE=mTL_miRNA);FADS1 (morbid/RE=mTL_miRNA);FGFR1 (HI=3/morbid/RE=mTL_miRNA);FOLR1 (morbid/RE=mTL_miRNA);FOXP1 (HI=3/morbid/RE=mTL_miRNA);FREM1 (morbid/RE=mTL_miRNA);FRMPD4 (morbid/RE=mTL_miRNA);FXR1 (morbid/RE=mTL_miRNA);FZD2 (morbid/RE=mTL_miRNA);GALM (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GBA2 (morbid/RE=mTL_miRNA);GFPT1 (morbid/RE=mTL_miRNA);GIPC1 (morbid/RE=mTL_miRNA);GJB1 (morbid/RE=mTL_miRNA);GLUD1 (morbid/RE=mTL_miRNA);GLUL (morbid/RE=mTL_miRNA);GM2A (morbid/RE=mTL_miRNA);GNAI2 (morbid/RE=mTL_miRNA);GNAL (morbid/RE=mTL_miRNA);GOLGA2 (morbid/RE=mTL_miRNA);GON7 (morbid/RE=mTL_miRNA);GRK1 (morbid/RE=mTL_miRNA);GRM6 (morbid/RE=mTL_miRNA);GSR (morbid/RE=mTL_miRNA);HAAO (morbid/RE=mTL_miRNA);HACE1 (morbid/RE=mTL_miRNA);HINT1 (morbid/RE=mTL_miRNA);HLCS (morbid/RE=mTL_miRNA);HMGA2 (morbid/RE=mTL_miRNA);HNRNPA1 (morbid/RE=mTL_miRNA);HNRNPK (HI=3/morbid/RE=mTL_miRNA);HNRNPU (morbid/RE=mTL_miRNA);IDS (HI=3/morbid/RE=mTL_miRNA);IFNAR1 (morbid/RE=mTL_miRNA);IGF1R (HI=3/morbid/RE=mTL_miRNA);IGF2R (morbid/RE=mTL_miRNA);IKBKG (HI=3/morbid/RE=mTL_miRNA);IL10RA (morbid/RE=mTL_miRNA);IL17RA (morbid/RE=ABC_enhancer);ISCU (morbid/RE=mTL_miRNA);JAG2 (morbid/RE=mTL_miRNA);KCND3 (morbid/RE=mTL_miRNA);KCNH2 (HI=3/morbid/RE=mTL_miRNA);KCNK3 (morbid/RE=mTL_miRNA);KDM6B (morbid/RE=mTL_miRNA);KIAA1549 (morbid/RE=mTL_miRNA);KITLG (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KLHL7 (morbid/RE=mTL_miRNA);KMT2A (HI=3/morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);KRT74 (morbid/RE=mTL_miRNA);L2HGDH (morbid/RE=mTL_miRNA);LMNB2 (morbid/RE=mTL_miRNA);MAPK1 (morbid/RE=ABC_enhancer+mTL_miRNA);MAPK8IP3 (morbid/RE=mTL_miRNA);MAPKBP1 (morbid/RE=mTL_miRNA);MATR3 (morbid/RE=mTL_miRNA);MCC (morbid/RE=mTL_miRNA);MCFD2 (morbid/RE=mTL_miRNA);MCM10 (morbid/RE=mTL_miRNA);MECP2 (HI=3/morbid/RE=mTL_miRNA);MED12L (morbid/RE=mTL_miRNA);MED17 (morbid/RE=mTL_miRNA);MIEF1 (morbid/RE=mTL_miRNA);MPV17 (morbid/RE=mTL_miRNA);MRAS (morbid/RE=mTL_miRNA);MRE11 (morbid/RE=mTL_miRNA);MRPL44 (morbid/RE=mTL_miRNA);MSL3 (HI=3/morbid/RE=mTL_miRNA);MTHFD1 (morbid/RE=mTL_miRNA);MYC (morbid/RE=mTL_miRNA);MYH14 (morbid/RE=mTL_miRNA);MYO5A (morbid/RE=mTL_miRNA);NACC1 (morbid/RE=mTL_miRNA);NANOS1 (morbid/RE=mTL_miRNA);NDST1 (morbid/RE=mTL_miRNA);NECTIN1 (morbid/RE=mTL_miRNA);NEUROD1 (morbid/RE=mTL_miRNA);NEUROD2 (morbid/RE=mTL_miRNA);NF2 (HI=3/morbid/RE=mTL_miRNA);NKAP (morbid/RE=mTL_miRNA);NRL (morbid/RE=mTL_miRNA);NUMA1 (morbid/RE=mTL_miRNA);NUS1 (HI=3/morbid/RE=mTL_miRNA);OGT (morbid/RE=mTL_miRNA);PACS1 (morbid/RE=mTL_miRNA);PDHA1 (HI=3/morbid/RE=mTL_miRNA);PDZD8 (morbid/RE=mTL_miRNA);PERP (morbid/RE=mTL_miRNA);PEX26 (morbid/RE=ABC_enhancer+EA_enhancer+mTL_miRNA);PHF8 (HI=3/morbid/RE=mTL_miRNA);PISD (morbid/RE=mTL_miRNA);PITX3 (morbid/RE=mTL_miRNA);PKD1 (HI=3/morbid/RE=mTL_miRNA);PLCD1 (morbid/RE=mTL_miRNA);POFUT1 (morbid/RE=mTL_miRNA);POLR3K (morbid/RE=mTL_miRNA);POMGNT1 (morbid/RE=mTL_miRNA);POU3F3 (morbid/RE=mTL_miRNA);PPP1R12A (morbid/RE=mTL_miRNA);PPP2CA (morbid/RE=mTL_miRNA);PPP2R1B (morbid/RE=mTL_miRNA);PPP2R5D (morbid/RE=mTL_miRNA);PRRT2 (HI=3/morbid/RE=mTL_miRNA);PTPA (morbid/RE=mTL_miRNA);PUM1 (morbid/RE=mTL_miRNA);PUS3 (morbid/RE=mTL_miRNA);QRSL1 (morbid/RE=mTL_miRNA);RAB11B (morbid/RE=mTL_miRNA);RHOA (morbid/RE=mTL_miRNA);RNF170 (morbid/RE=mTL_miRNA);RTN2 (morbid/RE=mTL_miRNA);SALL4 (HI=3/morbid/RE=mTL_miRNA);SBF1 (morbid/RE=mTL_miRNA);SCAF4 (morbid/RE=mTL_miRNA);SCD (morbid/RE=mTL_miRNA);SCN2B (morbid/RE=mTL_miRNA);SCUBE3 (morbid/RE=mTL_miRNA);SELENON (morbid/RE=mTL_miRNA);SERPINC1 (morbid/RE=mTL_miRNA);SET (morbid/RE=mTL_miRNA);SETD1B (morbid/RE=mTL_miRNA);SF1 (morbid/RE=mTL_miRNA);SGCD (morbid/RE=mTL_miRNA);SH3TC2 (morbid/RE=mTL_miRNA);SIX1 (morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC10A7 (morbid/RE=mTL_miRNA);SLC30A7 (morbid/RE=mTL_miRNA);SLC31A1 (morbid/RE=mTL_miRNA);SLC4A1 (morbid/RE=mTL_miRNA);SLC6A17 (morbid/RE=mTL_miRNA);SLC9A1 (morbid/RE=mTL_miRNA);SLC9A7 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SOX4 (morbid/RE=mTL_miRNA);SPPL2A (morbid/RE=mTL_miRNA);SPRY4 (morbid/RE=mTL_miRNA);SRCAP (morbid/RE=mTL_miRNA);SRD5A3 (morbid/RE=mTL_miRNA);SREBF1 (morbid/RE=mTL_miRNA);STIM1 (morbid/RE=mTL_miRNA);STK4 (morbid/RE=mTL_miRNA);SUOX (morbid/RE=mTL_miRNA);SYT2 (morbid/RE=mTL_miRNA);TAOK1 (HI=3/morbid/RE=mTL_miRNA);TBL1X (morbid/RE=mTL_miRNA);TEAD1 (morbid/RE=mTL_miRNA);TET3 (morbid/RE=mTL_miRNA);TG (morbid/RE=mTL_miRNA);TGFB1 (morbid/RE=mTL_miRNA);THRA (morbid/RE=mTL_miRNA);THSD4 (morbid/RE=mTL_miRNA);TIMM8A (HI=3/morbid/RE=mTL_miRNA);TMEM126B (morbid/RE=mTL_miRNA);TMEM127 (HI=3/RE=mTL_miRNA);TMEM63C (morbid/RE=mTL_miRNA);TNPO2 (morbid/RE=mTL_miRNA);TNRC6B (HI=3/morbid/RE=mTL_miRNA);TP53 (HI=3/morbid/RE=mTL_miRNA);TPI1 (morbid/RE=mTL_miRNA);TPM3 (morbid/RE=mTL_miRNA);TRAF7 (morbid/RE=mTL_miRNA);TRDN (morbid/RE=mTL_miRNA);TRIM71 (morbid/RE=mTL_miRNA);TRMT5 (morbid/RE=mTL_miRNA);TRPM3 (morbid/RE=mTL_miRNA);TRRAP (morbid/RE=mTL_miRNA);TUBA8 (morbid/RE=ABC_enhancer+EA_enhancer+GH_enhancer+GH_promoter_enhancer);TUBB (morbid/RE=mTL_miRNA);TULP1 (morbid/RE=mTL_miRNA);U2AF2 (morbid/RE=mTL_miRNA);UMPS (morbid/RE=mTL_miRNA);USB1 (morbid/RE=mTL_miRNA);USH1G (morbid/RE=mTL_miRNA);USP18 (morbid/RE=ABC_enhancer+EA_enhancer+GH_enhancer);VPS51 (morbid/RE=mTL_miRNA);WBP11 (morbid/RE=mTL_miRNA);WBP2 (morbid/RE=mTL_miRNA);WDR45B (morbid/RE=mTL_miRNA);XPC (morbid/RE=mTL_miRNA);XRCC2 (morbid/RE=mTL_miRNA);ZBTB16 (morbid/RE=mTL_miRNA);ZBTB20 (morbid/RE=mTL_miRNA);ZBTB7A (morbid/RE=mTL_miRNA);ZFYVE27 (morbid/RE=mTL_miRNA) 22q11.2 recurrent (DGS/VCFS) region (proximal, A-B) (includes TBX1) TS3:ISCA-37433;dbVar:nssv15121202;dbVar:nssv15132168;dbVar:nssv15132429;dbVar:nssv15132430;dbVar:nssv15132553;dbVar:nssv15132642;nssv15139997;dbVar:nssv15132749;dbVar:nssv15133139;dbVar:nssv15133442;dbVar:nssv15133527;dbVar:nssv15133528;dbVar:nssv15133531;dbVar:nssv15133921;dbVar:nssv15134211;dbVar:nssv15134239;dbVar:nssv15134353;dbVar:nssv15136015;dbVar:nssv15137439;dbVar:nssv15138177;dbVar:nssv15138869;dbVar:nssv15140282;dbVar:nssv15141369;dbVar:nssv15153269;dbVar:nssv15156361;dbVar:nssv15605811;dbVar:nssv15605831;dbVar:nssv15605876;dbVar:nssv15755816;dbVar:nssv16207465;dbVar:nssv16736612;dbVar:nssv16736616;dbVar:nssv18830899;dbVar:nssv18830992 22:18894836-20311784;22:18894836-21461752;22:18894836-21464119;22:18896973-21440514;22:18900756-21075586;22:18908833-21358123;22:18909039-21440514;22:18909045-21464119;22:18912232-20287208;22:18912515-21431174;22:18916828-21050078;22:18916829-20312661;22:18916843-20311810;22:18916843-20311858;22:18916843-20312661;22:18919943-20311763;22:18919943-20659606;22:18919943-20708934;22:18919943-21440514;22:18923899-21431174;22:18937381-21459713;22:18938162-21455556;22:18950767-21455556;22:18970562-21040836;22:18973253-21435405;22:19168759-20942862;22:20895156-21374512;22:20958985-21379958;22:21044197-21440455;22:21045039-21455556;22:21065883-21440455;22:21081261-21440455;22:21086707-21445960;22:21300291-21331188 22q11.2 recurrent (DGS/VCFS) region (proximal, A-B) (includes TBX1);Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR;Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR;Combined D-2- and L-2-hydroxyglutaric aciduria, 615182 (3) AR;Myasthenic syndrome, congenital, 23, presynaptic, 618197 (3) AR;Conotruncal anomaly face syndrome, 217095 (3);DiGeorge syndrome, 188400 (3) AD;Tetralogy of Fallot, 187500 (3) AD;Velocardiofacial syndrome, 192430 (3) AD;Gastrointestinal defects and immunodeficiency syndrome 2, 619708 (3) AR;Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis, 616531 (3) AR;Spastic paraplegia 84, AR, 619621 (3) AR;Hyperprolinemia, type I, 239500 (3) AR;Schizophrenia, susceptibility to, 4, 600850 (3) AD;Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, 616878 (3) AR;Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;Schwannomatosis-2, susceptibility to, 615670 (3) AD;Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome|Cardiac_arrhythmia|Seizure|Acute_rhabdomyolysis|Episodic_flaccid_weakness|Intellectual_disability;Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD;Van den Ende-Gupta syndrome, 600920 (3) AR;|DiGeorge_syndrome HP:0000730;HP:0001249;HP:0001250;HP:0001267;HP:0001275;HP:0001286;HP:0001303;HP:0001656;HP:0001661;HP:0001665;HP:0001666;HP:0001687;HP:0001721;HP:0002122;HP:0002125;HP:0002182;HP:0002192;HP:0002279;HP:0002306;HP:0002316;HP:0002348;HP:0002382;HP:0002386;HP:0002391;HP:0002402;HP:0002417;HP:0002430;HP:0002431;HP:0002432;HP:0002434;HP:0002437;HP:0002458;HP:0002466;HP:0002479;HP:0002482;HP:0002499;HP:0002543;HP:0002794;HP:0003752;HP:0003767;HP:0004351;HP:0005158;HP:0006833;HP:0006997;HP:0007154;HP:0007176;HP:0007180;HP:0008942;HP:0010520;HP:0011675 CLN:226591;CLN:2871255;CLN:959024;HI3:ISCA-37433;dbVar:nssv15119864;dbVar:nssv15120710;dbVar:nssv15124351;dbVar:nssv15124515;dbVar:nssv15129189;dbVar:nssv15130834;dbVar:nssv15130929;dbVar:nssv15131088;dbVar:nssv15131611;dbVar:nssv15132323;nssv15139981;dbVar:nssv15132334;dbVar:nssv15132747;dbVar:nssv15132748;dbVar:nssv15132933;dbVar:nssv15132934;dbVar:nssv15132935;dbVar:nssv15132939;dbVar:nssv15133099;dbVar:nssv15133185;dbVar:nssv15133186;dbVar:nssv15133443;dbVar:nssv15133817;dbVar:nssv15134350;nssv15139984;dbVar:nssv15134354;dbVar:nssv15134360;dbVar:nssv15134361;dbVar:nssv15134635;dbVar:nssv15134703;dbVar:nssv15134820;dbVar:nssv15134849;dbVar:nssv15136233;dbVar:nssv15137726;dbVar:nssv15137759;dbVar:nssv15137802;dbVar:nssv15138106;dbVar:nssv15138475;dbVar:nssv15139405;dbVar:nssv15139434;dbVar:nssv15139445;nssv15774763;dbVar:nssv15139759;dbVar:nssv15140043;dbVar:nssv15140048;dbVar:nssv15140057;dbVar:nssv15141198;dbVar:nssv15141722;dbVar:nssv15142496;dbVar:nssv15143197;dbVar:nssv15143645;dbVar:nssv15144279;dbVar:nssv15144449;dbVar:nssv15153165;dbVar:nssv15154011;dbVar:nssv15155693;dbVar:nssv15156360;dbVar:nssv15162020;dbVar:nssv15162021;dbVar:nssv15605807;dbVar:nssv15605829;dbVar:nssv15605830;nssv16216546;dbVar:nssv15605834;dbVar:nssv15755310;dbVar:nssv15755712;dbVar:nssv15755812;dbVar:nssv15770037;dbVar:nssv15770783;dbVar:nssv15770877;dbVar:nssv15772938;nssv15773614;nssv15775115;nssv15775184;nssv15775592;dbVar:nssv15772982;dbVar:nssv15775129;dbVar:nssv15776509;dbVar:nssv15776863;dbVar:nssv15776865;dbVar:nssv15776871;dbVar:nssv16208595;dbVar:nssv16208596;dbVar:nssv16212111;dbVar:nssv16213307;dbVar:nssv16213808;dbVar:nssv16214784;dbVar:nssv16215255;dbVar:nssv16215257;dbVar:nssv16216543;dbVar:nssv16216544;nssv8639845;nssv15161831;dbVar:nssv16254574;dbVar:nssv16254739;dbVar:nssv16255831;dbVar:nssv16736634;dbVar:nssv17171460;nssv17974163;dbVar:nssv17171461;dbVar:nssv17171462;dbVar:nssv17171559;dbVar:nssv17171582;dbVar:nssv17171772;dbVar:nssv17649936;dbVar:nssv17649973;dbVar:nssv17955605;dbVar:nssv17955606;dbVar:nssv17955868;dbVar:nssv17970829;dbVar:nssv17971092;dbVar:nssv17971094;dbVar:nssv17971356;dbVar:nssv17971399;dbVar:nssv17977042;dbVar:nssv18329601;dbVar:nssv18329824;dbVar:nssv18330264;dbVar:nssv18330322;dbVar:nssv18330820;dbVar:nssv18786380;dbVar:nssv18790095;dbVar:nssv18792883;dbVar:nssv18841927;nssv18830898;dbVar:nssv8639589;nssv15122532;morbid:GP1BB;morbid:LZTR1;morbid:PI4KA;morbid:PRODH;morbid:SCARF2;morbid:SERPIND1;morbid:SLC25A1;morbid:SNAP29;morbid:TANGO2;morbid:TBX1 22:18894836-20238206;22:18894836-20311763;22:18894836-20659606;22:18894836-21440514;22:18894836-21461752;22:18894836-21461811;22:18894836-21464119;22:18896973-20311763;22:18896973-21382953;22:18896973-21440514;22:18899288-18925066;22:18900294-18924066;22:18900295-18923806;22:18900443-21440514;22:18900669-18923820;22:18900669-19747220;22:18900669-19770565;22:18900689-21351637;22:18900896-18923882;22:18901005-21408430;22:18905110-19015451;22:18910311-18923800;22:18910311-18923820;22:18910311-19770565;22:18912232-20287208;22:18912404-21431174;22:18912871-21431174;22:18915348-21463730;22:18916828-20311858;22:18916829-20312661;22:18916829-21041014;22:18916829-21049800;22:18916843-19004772;22:18916843-20310938;22:18916843-20311858;22:18916843-20312661;22:18916843-20716903;22:18916843-20767095;22:18916843-21011216;22:18916843-21033371;22:18916843-21075592;22:18916844-20311858;22:18916844-21033401;22:18916844-21075592;22:18918742-20311922;22:18919580-21460595;22:18919943-20311763;22:18919943-20659606;22:18919943-20708934;22:18919943-21025713;22:18919943-21440514;22:18922152-21449911;22:18938162-20229017;22:18938162-20996250;22:18938162-21455556;22:18962314-21455556;22:18973253-21435405;22:18999804-21455499;22:18999804-21455556;22:19016664-21463730;22:19023802-21440455;22:19023802-21440514;22:19035018-21461811;22:19035324-21464119;22:19036287-21208284;22:19058830-21440514;22:19156118-19529130;22:19163094-19166249;22:19163624-19770565;22:19184001-21416024;22:19336599-21208828;22:19470352-19481849;22:19647906-21153690;22:19709401-21142058;22:19709436-19712313;22:19709952-19963280;22:19710419-21142058;22:19711062-19712294;22:19711829-19711877;22:19743227-19755855;22:19743425-19747210;22:19743425-19754400;22:19743425-19770565;22:19743474-19747220;22:19747168-19754390;22:19748301-19754857;22:19748451-19748647;22:20008633-20054687;22:20027161-20063237;22:20028564-20053554;22:20028990-20062723;22:20028993-20062955;22:20029136-20062954;22:20029701-20062756;22:20030823-20041691;22:20030823-20053554;22:20030859-20052185;22:20030879-20049206;22:20030879-20052185;22:20036383-20045782;22:20036384-20045781;22:20036385-20045784;22:20039969-20043556;22:20708891-21407690;22:20718171-21427936;22:20733496-21463730;22:20745763-21460658;22:20754408-21440515;22:20754408-21457610;22:20754423-21461752;22:20778874-20792112;22:20921343-21459713;22:21061979-21213099;22:21062169-21463730;22:21062567-21463730;22:21065883-21455556;22:21067570-21414817;22:21069074-21463730;22:21074921-21440514;22:21075576-21454721;22:21081285-21457610;22:21128401-21142008;22:21213295-21245502;22:21335907-21346541;22:21336586-21353321;22:21336662-21337398;22:21336662-21351637;22:21348908-21348985 CLN:1349334;dbVar:nssv17974796 22:21337344-21337343;22:21337344-21337456 22q11.2 recurrent (DGS/VCFS) region (proximal, A-D) (includes TBX1) dbVar:nssv15161990;dbVar:nssv15139753;dbVar:nssv15150031;dbVar:nssv15150491;dbVar:nssv15146973;dbVar:nssv15135173;dbVar:nssv15137211;dbVar:nssv15129128;dbVar:nssv15161991;dbVar:nssv15161992;dbVar:nssv15164031;dbVar:nssv16254742;dbVar:nssv16297047;dbVar:nssv15151140;nssv16207460;dbVar:nssv15141953;dbVar:nssv15156366;nssv15772157;dbVar:nssv17976875;dbVar:nssv16207463;dbVar:nssv16296938;dbVar:nssv16207464;dbVar:nssv15774756;dbVar:nssv18329565;dbVar:nssv15149512;nssv15150794;dbVar:nssv15139758;dbVar:nssv15755803;dbVar:nssv15774287;dbVar:nssv15605979;dbVar:nssv15139756;dbVar:nssv15605980;dbVar:nssv15137771;dbVar:nssv15132295;dbVar:nssv15133039;dbVar:nssv15133301;dbVar:nssv15132518;dbVar:nssv15134365;dbVar:nssv15146613;dbVar:nssv15133111;dbVar:nssv15147269;dbVar:nssv15121201;dbVar:nssv15136264;dbVar:nssv15605803;dbVar:nssv15605804;dbVar:nssv16736606;dbVar:nssv15128891;dbVar:nssv15126571;dbVar:nssv15128500;dbVar:nssv16254735;dbVar:nssv15140068;dbVar:nssv15137505;dbVar:nssv15128758;dbVar:nssv15152138;dbVar:nssv15154014;dbVar:nssv15755815;dbVar:nssv15755817;dbVar:nssv16255668;dbVar:nssv18329661;dbVar:nssv18330205;dbVar:nssv15156359;dbVar:nssv15142823;dbVar:nssv15140066;dbVar:nssv15133432;dbVar:nssv15605805;dbVar:nssv15605808;dbVar:nssv15605806;dbVar:nssv15132858;dbVar:nssv15133520;dbVar:nssv15132127;dbVar:nssv15133128;dbVar:nssv15136566;dbVar:nssv15133389;dbVar:nssv15140044;dbVar:nssv15133925;dbVar:nssv15138146;dbVar:nssv15133393;nssv15139545;dbVar:nssv15135020;dbVar:nssv15132566;dbVar:nssv15164039;dbVar:nssv17955656;dbVar:nssv15132423;dbVar:nssv15132330;dbVar:nssv15126758;dbVar:nssv15127771;dbVar:nssv15126436;dbVar:nssv17649918;dbVar:nssv15162011;dbVar:nssv15125959;dbVar:nssv17955842;dbVar:nssv15139556;dbVar:nssv15122631;dbVar:nssv15123767;dbVar:nssv15162014;dbVar:nssv15143627;dbVar:nssv16865904;dbVar:nssv15123759;dbVar:nssv17650003;dbVar:nssv15755805;dbVar:nssv15132167;dbVar:nssv15133526;dbVar:nssv15162019;dbVar:nssv15145463;dbVar:nssv15145234;dbVar:nssv16207634;dbVar:nssv15605810;dbVar:nssv15605809;dbVar:nssv18842027;dbVar:nssv18842024;nssv18842046;dbVar:nssv18326316;dbVar:nssv15139749;dbVar:nssv15140369;dbVar:nssv15136643;dbVar:nssv15131931;nssv15133075;dbVar:nssv15131925;dbVar:nssv15134715;dbVar:nssv15132426;TS3:ISCA-37446;dbVar:nssv15605828;dbVar:nssv15153271;dbVar:nssv17976874;dbVar:nssv15139887;dbVar:nssv15137698;dbVar:nssv15139242;dbVar:nssv18329574;dbVar:nssv18329591;dbVar:nssv17976884;dbVar:nssv15132247;nssv15139527;dbVar:nssv15131997;nssv15139348;dbVar:nssv15137835;dbVar:nssv15132026;nssv15139977;dbVar:nssv15127741;dbVar:nssv18830785;dbVar:nssv15154013;dbVar:nssv16254573;dbVar:nssv16255670;dbVar:nssv15133914;dbVar:nssv15145464;dbVar:nssv15755306;dbVar:nssv15132169;dbVar:nssv17976883;dbVar:nssv16207466;dbVar:nssv15132044;dbVar:nssv15139694;dbVar:nssv15120579;dbVar:nssv15133646;dbVar:nssv15139596;dbVar:nssv15132083;dbVar:nssv18330192;dbVar:nssv15139716;dbVar:nssv15135998;dbVar:nssv15139748 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7.30;22.85;7.31;7.30;7.30;3.96;33.54;0.82;39.86;7.32;7.32;7.34;54.67;1.08;41.40;41.41;51.11;47.57;26.78;23.86;7.49;1.08;7.49;57.40;42.19;43.53;40.40;43.01;46.89;5.65;48.62;54.10;54.78;62.54;34.92;7.61;31.55;7.61;11.71;47.16;89.81;89.86;84.15;83.29;78.51;7.88;83.04;84.41;90.95;78.43;91.08;91.10;91.25;78.36;91.21;85.21;81.56;85.23;91.25;91.25;91.30;91.31;91.08;91.31;91.28;78.78;91.62;90.35;60.55;85.87;90.14;91.61;91.67;90.35;85.65;18.95;92.10;44.45;92.97;93.09;89.33;85.66;80.20;97.92;98.08;98.05;98.94;99.08;98.81;99.34;99.24;99.43;99.69;56.67;99.81;99.82;98.25;96.18;99.87;99.80;93.79;99.84;99.84;99.91;99.94;99.96;99.96;99.98;99.98;98.42;98.42;96.35;88.17;88.42;99.94;84.78;99.94;88.20;99.94;99.94;99.94;88.38;88.21;99.94;98.40;96.31;88.29;88.06;96.31;99.97;99.94;99.94;66.78;96.11;84.09;99.96;91.60;99.79;16.39;95.23;94.50;26.11;91.39;33.45;31.88;29.84;90.26;1.24;2.81 22q11.2 recurrent (DGS/VCFS) region (proximal, A-D) (includes TBX1) dbVar:nssv15134634;dbVar:nssv16208592;dbVar:nssv16208593;dbVar:nssv15141423;dbVar:nssv15132388;dbVar:nssv15128094;dbVar:nssv15132068;dbVar:nssv15133055;dbVar:nssv18787557;nssv18791888;dbVar:nssv16207650;dbVar:nssv15153272;dbVar:nssv15135754;dbVar:nssv15133431;nssv15139986;dbVar:nssv15125556;dbVar:nssv15126775;dbVar:nssv15133864;dbVar:nssv15755811;dbVar:nssv15755813;dbVar:nssv18326404;dbVar:nssv15126915;dbVar:nssv15128185;dbVar:nssv15145459;dbVar:nssv15145460;dbVar:nssv15138286;dbVar:nssv15154015;nssv18326430;dbVar:nssv18330227;dbVar:nssv17976889;dbVar:nssv17976891;dbVar:nssv15153273;dbVar:nssv18330460;dbVar:nssv17976888;dbVar:nssv15145461;dbVar:nssv15138328;dbVar:nssv17976880;dbVar:nssv15154017;dbVar:nssv18329577;dbVar:nssv15140316;dbVar:nssv15133433;dbVar:nssv18326382;dbVar:nssv17955872;dbVar:nssv15133434;dbVar:nssv16255835;dbVar:nssv15132708;dbVar:nssv15134184;dbVar:nssv15132128;nssv15139349;dbVar:nssv15134982;dbVar:nssv15135883;dbVar:nssv15133394;nssv16091745;dbVar:nssv15132006;nssv15139990;dbVar:nssv15137884;dbVar:nssv15133435;dbVar:nssv18792765;dbVar:nssv15135454;dbVar:nssv15133438;nssv15140028;dbVar:nssv15132230;nssv15139684;dbVar:nssv15132655;nssv15139976;dbVar:nssv15136079;dbVar:nssv15132507;nssv15139975;dbVar:nssv15132389;dbVar:nssv17976452;dbVar:nssv15164040;dbVar:nssv15137872;dbVar:nssv16254738;dbVar:nssv15127636;dbVar:nssv15128166;dbVar:nssv15127784;dbVar:nssv16208773;dbVar:nssv15145231;dbVar:nssv15145040;dbVar:nssv18786377;dbVar:nssv15145232;dbVar:nssv15139558;dbVar:nssv15163611;dbVar:nssv16215256;dbVar:nssv15128065;dbVar:nssv17955534;dbVar:nssv15163612;dbVar:nssv15145462;dbVar:nssv15145233;dbVar:nssv15163613;dbVar:nssv15132390;dbVar:nssv15163614;dbVar:nssv15162012;dbVar:nssv15139255;dbVar:nssv15162013;dbVar:nssv15162015;dbVar:nssv17976449;dbVar:nssv17955549;dbVar:nssv15162016;nssv16215222;nssv16215239;nssv16865884;dbVar:nssv15162017;dbVar:nssv15164042;dbVar:nssv15143222;dbVar:nssv15162018;dbVar:nssv16865881;dbVar:nssv15164043;dbVar:nssv15755824;dbVar:nssv17650004;dbVar:nssv17649858;dbVar:nssv16297048;dbVar:nssv17517456;dbVar:nssv15141730;dbVar:nssv15126093;dbVar:nssv15125439;dbVar:nssv15755804;dbVar:nssv15121171;dbVar:nssv15133439;dbVar:nssv15132392;dbVar:nssv15132132;dbVar:nssv15133440;dbVar:nssv15136213;dbVar:nssv15605874;nssv15605879;dbVar:nssv17976881;dbVar:nssv15119655;dbVar:nssv18842051;dbVar:nssv17173212;dbVar:nssv17173202;dbVar:nssv18792648;dbVar:nssv16091922;dbVar:nssv15143862;dbVar:nssv17976675;dbVar:nssv18830700;dbVar:nssv18786378;dbVar:nssv18786379;dbVar:nssv15140698;dbVar:nssv15139562;dbVar:nssv15140747;dbVar:nssv15140051;dbVar:nssv15133317;nssv15143213;dbVar:nssv15131926;dbVar:nssv15605919;dbVar:nssv15755810;HI3:ISCA-37446;dbVar:nssv15139269;dbVar:nssv15137499;dbVar:nssv15138712;dbVar:nssv18330193;dbVar:nssv15139855;nssv18326386;dbVar:nssv15139854;nssv15153270;dbVar:nssv15154016;nssv17976890;dbVar:nssv15152149;dbVar:nssv15137491;dbVar:nssv18330326;dbVar:nssv18329598;dbVar:nssv18330218;dbVar:nssv15141653;dbVar:nssv15142207;dbVar:nssv15755814;dbVar:nssv15132248;nssv15139690;dbVar:nssv15134351;dbVar:nssv15132463;nssv15139699;dbVar:nssv15132523;dbVar:nssv15155695;dbVar:nssv18831006;dbVar:nssv17976279;dbVar:nssv15139289;dbVar:nssv15139467;dbVar:nssv15142401;dbVar:nssv15134356;dbVar:nssv18330006;dbVar:nssv15137446;dbVar:nssv17976741;dbVar:nssv15153268;dbVar:nssv15156357;dbVar:nssv18842023;dbVar:nssv15132608;dbVar:nssv15145465;dbVar:nssv15145466;dbVar:nssv15145235;dbVar:nssv15772502;dbVar:nssv15154008;dbVar:nssv15156354;dbVar:nssv15755308;nssv15755309;dbVar:nssv15155696;dbVar:nssv18330327;dbVar:nssv18326378;dbVar:nssv18329593;dbVar:nssv18330275;dbVar:nssv18329587;dbVar:nssv18329620;dbVar:nssv17956682;dbVar:nssv15776637;dbVar:nssv17649919;dbVar:nssv18326434;dbVar:nssv18326440;dbVar:nssv15120712;dbVar:nssv15139564;dbVar:nssv16208598;dbVar:nssv15755307;dbVar:nssv15156347;dbVar:nssv18330257;dbVar:nssv15755311;dbVar:nssv17957425;dbVar:nssv15121593;dbVar:nssv15154007;dbVar:nssv15134856;dbVar:nssv18330729;dbVar:nssv18330196;dbVar:nssv17977102 22:16087695-19363465;22:16888900-20125005;22:16888900-20730144;22:16888901-20026751;22:17019016-20718227;22:17177912-19892632;22:17397499-20311763;22:17397499-20708934;22:17565983-20052185;22:18475386-23764120;22:18626109-21800797;22:18628020-21464119;22:18628020-21505417;22:18628133-21561468;22:18628133-21883879;22:18628148-21440515;22:18631365-21800471;22:18636750-21800471;22:18639781-21910280;22:18641480-21712996;22:18641480-21722262;22:18642647-21717111;22:18642647-21742277;22:18644242-21465662;22:18644543-21465659;22:18644544-21800797;22:18644791-21798907;22:18644791-21800471;22:18644791-21915509;22:18644792-21041014;22:18645354-21800797;22:18646694-21631412;22:18648857-21465662;22:18648867-21798907;22:18648867-21800797;22:18648868-21465659;22:18650665-21440455;22:18650676-21455556;22:18655799-21726191;22:18660136-21737597;22:18660554-21455556;22:18661700-21457610;22:18661700-21505445;22:18661725-20659606;22:18661725-21440514;22:18661725-21461811;22:18661725-21464119;22:18661725-21505417;22:18661725-21561514;22:18661725-21809009;22:18671630-21536841;22:18689517-21588615;22:18706002-20311763;22:18706002-20659606;22:18706002-21025713;22:18706002-21440514;22:18706002-21464119;22:18706002-21505417;22:18706002-21809009;22:18718029-21326012;22:18728119-21811991;22:18765086-21661435;22:18765103-21661435;22:18788000-21065894;22:18788000-21468378;22:18788000-21684798;22:18789966-21591197;22:18790223-21697998;22:18820423-21477877;22:18834446-21414817;22:18834453-21575702;22:18844633-21463730;22:18844633-21608479;22:18844633-21797812;22:18848021-21468378;22:18861210-21630630;22:18861749-21463730;22:18868433-20331055;22:18868433-21477877;22:18872509-21465050;22:18874457-20306317;22:18875870-21470273;22:18875957-21466715;22:18876631-21465659;22:18878410-21465050;22:18878410-21907671;22:18884515-21484289;22:18884715-21483289;22:18886916-21463730;22:18886916-21465050;22:18886916-21467387;22:18886916-21811991;22:18889491-20312668;22:18889491-21463730;22:18889491-21466715;22:18889491-21917190;22:18889572-21464697;22:18889694-21465485;22:18889951-21466053;22:18889970-21462658;22:18890043-21440455;22:18890163-21464056;22:18890222-21561468;22:18890265-21540347;22:18890272-18999862;22:18890272-20328113;22:18890272-20659606;22:18890272-21394730;22:18890272-21461811;22:18891527-21796215;22:18892576-21460220;22:18893345-21650280;22:18893736-18924066;22:18893839-20307561;22:18893883-21563420;22:18893883-21571027;22:18893887-21386103;22:18893888-18923800;22:18893889-18973671;22:18893889-21414817;22:18893889-21481925;22:18893889-21570386;22:18894079-21414817;22:18894340-20255110;22:18894340-20255154;22:18894340-21440455;22:18894340-21440514;22:18894836-21505417;22:18894836-21561514;22:18900756-21800277;22:18912232-21465672;22:18912232-21465672;22:18916828-21465662;22:18916829-21465659;22:18916829-21465662;22:18916829-21800797;22:18916843-21465659;22:18916843-21465662;22:18916843-21798907;22:18916843-21804716;22:18916843-21804886;22:18916844-21465659;22:18916844-21800471;22:18916844-21915509;22:18917048-21465659;22:18917048-21465662;22:18919478-21800471;22:18919943-21505417;22:18919943-21505558;22:18919943-21561514;22:18919943-21809009;22:18935464-21465659;22:18936190-21464809;22:18936191-21464809;22:18970562-21465662;22:19024657-21465659;22:19024658-21465662;22:19029603-21505417;22:19046678-21465662;22:20279767-23822986;22:20310411-21804886;22:20311904-21465659;22:20311904-21800797;22:20609933-21576553;22:20659548-21561514;22:20703817-21503296;22:20703817-21631412;22:20713276-21477877;22:20716877-21465659;22:20716877-21465662;22:20716877-21798907;22:20716877-21800471;22:20716877-23819697;22:20716878-21465659;22:20725309-21465659;22:20725310-21804563;22:20725319-21800797;22:20728958-21798907;22:20728958-21800797;22:20728958-21915096;22:20729389-21465662;22:20730997-21465342;22:20732809-21465659;22:20732809-21800471;22:20733428-21505417;22:20749626-23972878;22:21029656-22481498;22:21033587-21800471;22:21049800-21465662;22:21049801-21465662;22:21059670-21800471;22:21059670-21804716;22:21065883-21937680;22:21075676-21465662;22:21081261-24593820;22:21092649-21465662;22:21188488-21804597;22:21462567-22962196 14.31;38.01;47.78;36.07;49.29;36.76;48.62;54.78;46.55;48.58;80.93;90.59;89.29;87.59;78.92;90.52;81.07;81.21;78.56;83.65;83.40;83.57;82.89;91.06;91.07;81.40;81.46;81.42;78.55;89.57;81.42;86.08;91.21;81.56;81.51;91.21;91.25;91.30;83.68;83.49;91.62;91.66;90.35;88.33;91.61;91.67;91.68;90.35;88.60;81.63;89.67;88.62;88.24;90.33;91.86;93.09;93.15;91.78;82.80;93.22;83.31;88.71;88.71;95.31;95.86;88.69;91.72;88.36;96.68;97.66;93.73;98.08;92.96;87.00;98.05;92.77;98.73;98.19;98.46;99.10;98.58;99.03;99.17;99.24;99.33;84.82;98.83;98.87;99.69;99.66;99.57;87.84;99.62;99.79;99.69;84.86;99.77;99.75;99.74;99.81;99.81;99.82;96.18;96.95;95.84;99.68;99.74;99.82;99.82;88.45;99.91;93.19;96.37;99.93;96.24;95.97;99.96;96.83;98.81;99.96;99.28;95.99;99.97;99.96;99.96;99.98;99.98;98.42;96.35;88.41;99.94;99.94;99.94;99.94;99.94;88.33;99.94;99.94;88.38;88.21;88.20;99.94;88.34;84.95;99.94;99.94;88.33;98.40;98.40;96.31;88.06;99.94;99.97;99.97;99.94;99.94;99.94;98.33;99.94;33.43;77.20;99.87;77.39;88.37;89.20;95.10;81.96;98.20;99.79;99.79;69.06;68.96;24.08;99.79;99.79;68.46;68.70;68.71;68.59;61.98;99.79;99.83;99.79;68.50;94.65;22.17;29.92;56.14;99.63;99.63;54.60;54.29;45.68;99.60;10.90;99.59;44.74;0.10 382 2-hydroxyglutaric_aciduria;Abnormality_of_metabolism/homeostasis;Acute_rhabdomyolysis;Autism_spectrum_disorder;Bardet-Biedl_syndrome;Bernard_Soulier_syndrome;CEDNIK_syndrome;CLDN5-related_neurodevelopmental_disorder;Cardiac_arrhythmia;Cardiovascular_phenotype;D,L-2-hydroxyglutaric_aciduria;DiGeorge_syndrome;Episodic_flaccid_weakness;Fetal_cystic_hygroma;Hereditary_cancer-predisposing_syndrome;Hypomyelinating_leukodystrophy_2;Inborn_genetic_diseases;Intellectual_disability;LZTR1-related_condition;LZTR1-related_disorders;Macrothrombocytopenia;Meier-Gorlin_syndrome_7;Metabolic_crises_with_rhabdomyolysis,_cardiac_arrhythmias,_and_neurodegeneration;Mild_macrothrombocytopenia;Myasthenic_syndrome,_congenital,_23,_presynaptic;Noonan_syndrome;Noonan_syndrome_10;Noonan_syndrome_2;Noonan_syndrome_and_Noonan-related_syndrome;PI4KA-Related_Disorders;Polymicrogyria,_perisylvian,_with_cerebellar_hypoplasia_and_arthrogryposis;Proline_dehydrogenase_deficiency;RASopathy;Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome;SLC25A1-related_condition;Schwannomatosis;Schwannomatosis_2;See_cases;Seizure;Short_stature;Spastic_paraplegia_84,_autosomal_recessive;Thrombocytopenia;Van_den_Ende-Gupta_syndrome;Velocardiofacial_syndrome IMH 22:17036164-22613666 0.1686 22:18667571-18994853 DDD:56146;22:18877788-19033532 dgv543n27;chr22:18884850-18926400 dbVar;chr22:18897380-18897885 dbVar;chr22:18905003-18905655 dbVar;chr22:18908214-18916245 dbVar;chr22:18912157-18998999 dbVar;22:18912158-18998999 esv3647250;chr22:18917245-18921869 dbVar;chr22:18922181-18922289 dbVar;22:18924000-18940000 gnomAD-SV_v2.1_DUP_22_50652;chr22:18932850-18939000 dbVar;chr22:18946999-18963000 dbVar;chr22:18959589-18974015 dbVar;chr22:18979229-18981697 dbVar;chr22:18991101-19003643 dbVar;chr22:18998500-19027500 dbVar;chr22:19006877-19007455 dbVar;chr22:19023959-19024069 dbVar;chr22:19031999-19054000 dbVar;chr22:19072999-19342000 dbVar... 22:18655861-19006984 dgv99e203;22:18876429-19006125 DDD:56173;22:18882313-19012377 DDD:56174;22:18884850-18926400 gnomAD-SV_v2.1_DUP_22_50647;chr22:18897885-18898551 dbVar;chr22:18908116-18908214 dbVar;22:18911000-18917000 gnomAD-SV_v2.1_DUP_22_50649;22:18912158-18998999 1000g;chr22:18915430-18916245 dbVar;chr22:18920000-18927000 dbVar;chr22:18924000-18940000 dbVar;chr22:18928500-18933600 dbVar;chr22:18936140-18938323 dbVar;chr22:18958405-18962239 dbVar;chr22:18976999-19012000 dbVar;chr22:18986988-18991101 dbVar;chr22:18995665-18996607 dbVar;chr22:19006777-19007455 dbVar;chr22:19015177-19088691 dbVar;chr22:19030334-19103057 dbVar;chr22:19050376-19063398 dbVar... chr22:18884925-18927000 dbVar;chr22:18912157-18998999 dbVar;chr22:18920358-18923595 dbVar;chr22:18934402-18934486 dbVar;chr22:18938445-18969406 dbVar;chr22:18961454-18962214 dbVar;chr22:18977575-18977640 dbVar;chr22:18977576-18977640 dbVar;chr22:18979860-18979920 dbVar;chr22:18984228-18985696 dbVar;chr22:18994879-18998062 dbVar;chr22:18997267-19009786 dbVar;chr22:19008418-19009937 dbVar;chr22:19041070-19041296 dbVar;chr22:19050181-19050386 dbVar;chr22:19063483-19063613 dbVar;22:19063767-19063900 gnomAD-SV_v2.1_DEL_22_181349;chr22:19087245-19091323 dbVar;chr22:19091546-19099675 dbVar;chr22:19099906-19100607 dbVar;22:19099907-19100607 esv3647259... chr22:18884924-19013000 dbVar;chr22:18902898-18902992 dbVar;chr22:18912910-18913458 dbVar;chr22:18929400-18935100 dbVar;chr22:18934999-21466000 dbVar;chr22:18943458-18943555 dbVar;chr22:18961457-18962214 dbVar;22:18977576-18977640 1000g;22:18977576-18977640 gnomAD-SV_v2.1_DEL_22_181334;chr22:18980769-18984165 dbVar;chr22:18990004-18990064 dbVar;chr22:18997195-19009720 dbVar;chr22:19006733-19006786 dbVar;chr22:19008684-19010259 dbVar;chr22:19050028-19050086 dbVar;chr22:19054635-19055096 dbVar;chr22:19063767-19063900 dbVar;chr22:19085539-19085825 dbVar;chr22:19091504-19102801 dbVar;22:19098616-19100995 dgv1286e212;22:19099907-19100607 1000g... 325921;868289;16521;344527;344990;336054;337864;1189150;2526221;921730;347979;681737;674280;676645;64889;73372;74042;14568;552226;393066;393067;606697;1010990;1011193;1011198;1011201;1011203;988609;1919439;2386524;1215466;3038163;334661;1009921;347980;540341;366288;357345;101360;153623;1311717;1782887;2534354;2206583;844141;1573312;666970;81317;557557;612401;227094;... loss;gain 0.445 0.320 22:18894850-18894969 L1ME2z 22:21464126-21464591 L1MA7 22:18889511-18912230 1 97.89 -0.807902299547855 -1.20830830104818 -0.791505674827999 2.94244265911253 5.29477062168781 606810;190315;603465;138720;602054;606448;116790;616830;605566;613619;600286;142360;604202;600574 yes yes 0 1.0000e+00 1.0000e+00 1.9 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3C (76 genes, +0.90);5F (+0.00) 5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR6 NM_005675 6 18893832 18899601 4766 392 59 yes 5 intron2-txEnd CDS-3'UTR 597 5' 18894835 18899601 DDD:56146;DDD:56173;DDD:56174;dbVar;dgv543n27;dgv99e203;gnomAD-SV_v2.1_DUP_22_50647 22:18655861-19006984;22:18667571-18994853;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;chr22:18884850-18926400;22:18884850-18926400 0.0355 dbVar chr22:18884924-19013000;chr22:18884925-18927000 0.01 IMH 22:17036164-22613666;22:18655109-20719124 0.1686 61.1 -0.678746019468492 -0.22775445384527 8214 9 9.8176e-12 7.6210e-07 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 PRODH NM_016335 6 18900293 18923806 23513 1803 100 no 14 txStart-txEnd 5'UTR-3'UTR 18900293 18923806 dbVar:nssv17649973;dbVar:nssv17971399 22:18900295-18923806;22:18910311-18923800 9 Inborn_genetic_diseases;Proline_dehydrogenase_deficiency DDD:56146;DDD:56173;DDD:56174;dbVar;dgv543n27;dgv99e203;gnomAD-SV_v2.1_DUP_22_50647 22:18655861-19006984;22:18667571-18994853;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;chr22:18884850-18926400;22:18884850-18926400 0.0355 dbVar chr22:18884924-19013000;chr22:18884925-18927000 0.01 IMH 22:17036164-22613666;22:18655109-20719124 0.1686 64889;73372;74042;14568;540341;81317;227094 loss 30 0 45.38 0.360135634788785 0.772811927860626 hyperprolinemia type 1 AR Definitive;Strong;Supportive 10192398;12217952;12525555;15662599;19736351;20524212;20524212[PMID]_23462603[PMID];23462603;26978485;28202261;28851938;5031477 5625 606810 Hyperprolinemia, type I, 239500 (3) AR;(Schizophrenia, susceptibility to, 4), 600850 (3) AD AD;AR yes yes 6 5.3577e-12 4.7536e-06 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LOC122455341 NR_173081 1 18926981 18935206 8225 0 0 no 2 txStart-txEnd UTR 18926981 18935206 1000g;DDD:56146;DDD:56173;DDD:56174;dbVar;dgv543n27;dgv99e203;esv3647250;gnomAD-SV_v2.1_DUP_22_50652 22:18655861-19006984;22:18667571-18994853;22:18876429-19006125;22:18877788-19033532;22:18882313-19012377;chr22:18912157-18998999;22:18912158-18998999;22:18912158-18998999;chr22:18924000-18940000;22:18924000-18940000 0.0355 dbVar chr22:18884924-19013000;chr22:18912157-18998999 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851 0.1686 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR5 NR_110533 2 18957980 19018755 60775 0 0 no 6 txStart-txEnd UTR 18957980 19018755 dgv543n27 22:18877788-19033532 0.0100 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847 0.4801 26220 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM246C NM_001396027 1 19017036 19017734 698 696 100 no 3 txStart-txEnd 5'UTR-3'UTR 19017036 19017734 dbVar;dgv543n27 22:18877788-19033532;chr22:18998500-19027500;chr22:19015177-19088691 0.0100 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 117134596 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR2 NM_005137 3 19023798 19109925 86127 1653 100 no 10 txStart-txEnd 5'UTR-3'UTR 19023798 19109925 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 768143;122920;768144;768145;742665;205629;742666;768146;724948;2058016;2381098 gain;loss 39.12 -0.375038933750903 0.817637812863819 schizophrenia AD Limited 9993 4 5.1573e-06 1.0959e-03 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR11 NR_024157 1 19033674 19035888 2214 0 0 no 1 txStart-txEnd UTR 19033674 19035888 dbVar chr22:19015177-19088691;chr22:19030334-19103057;chr22:19031999-19054000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 25786 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ESS2 NM_022719 3 19117791 19132164 14373 1431 100 no 10 txStart-txEnd 5'UTR-3'UTR 19117791 19132164 dbVar chr22:19072999-19342000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 8220 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TSSK2 NM_053006 5 19118820 19120135 1315 1077 88 no 1 txStart-txEnd 5'UTR-3'UTR 19118820 19120135 dbVar chr22:19072999-19342000;chr22:19096500-19120500 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 33.13 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.184731887964386 1.02819617031079 23617 6 3.8610e-03 4.1565e-03 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GSC2 NM_005315 2 19134505 19137805 3300 618 100 no 3 txStart-txEnd 5'UTR-3'UTR 19134505 19137805 dbVar chr22:19072999-19342000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 65.74 1.18735715980007 0.932740471460801 2928 9 4.4347e-03 3.7186e-02 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC01311 NR_103767 1 19159218 19160345 1127 0 0 no 1 txStart-txEnd UTR 19159218 19160345 dbVar chr22:19072999-19342000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 100652736 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SLC25A1 NM_001256534 2 19163093 19166018 2925 957 100 no 8 txStart-txEnd 5'UTR-3'UTR 19163093 19166018 9 2-hydroxyglutaric_aciduria;D,L-2-hydroxyglutaric_aciduria;Inborn_genetic_diseases;Myasthenic_syndrome,_congenital,_23,_presynaptic;SLC25A1-related_condition dbVar chr22:19072999-19342000 0.01 dbVar chr22:18934999-21466000;chr22:19161075-19192940 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 30 46.07 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.459211010381399 1.99698466418685 D,L-2-hydroxyglutaric aciduria;myasthenic syndrome, congenital, 23, presynaptic;presynaptic congenital myasthenic syndrome AD;AR Limited;Strong;Supportive 23561848;23561848[PMID]_23393310[PMID];26273529;26870663;29238895;31527857;31808147;NULL 6576 190315 Combined D-2- and L-2-hydroxyglutaric aciduria, 615182 (3) AR;Myasthenic syndrome, congenital, 23, presynaptic, 618197 (3) AR AR yes 3 5.8829e-02 6.3354e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CLTCL1 NM_007098 4 19166985 19279242 112257 4923 100 no 33 txStart-txEnd 5'UTR-3'UTR 19166985 19279242 dbVar chr22:19072999-19342000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 724952;22726;768149;546696 loss 72.86 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.597972033048653 -1.19469008098196 congenital insensitivity to pain with severe intellectual disability;multiple congenital anomalies/dysmorphic syndrome AD;AR Limited;Supportive 26068709[PMID] 8218 5 2.5101e-37 1.2408e-26 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 HIRA NM_003325 4 19318220 19419256 101036 3054 100 no 25 txStart-txEnd 5'UTR-3'UTR 19318220 19419256 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 724953;521179;520035 loss 0 0 19.48 -2.51547904504873 -2.53125239294469 -2.47162789907313 -0.543665561522748 3.98018572942351 7290 0 1.0000e+00 1.0000e+00 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MRPL40 NM_003776 4 19420067 19423598 3531 621 100 no 4 txStart-txEnd 5'UTR-3'UTR 19420067 19423598 dbVar chr22:19344390-19544397 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 54.99 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.0822917398873284 -0.450618700229176 64976 4 5.2924e-02 2.0082e-02 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 C22orf39 NM_173793 5 19428408 19435234 6826 318 100 no 3 txStart-txEnd 5'UTR-3'UTR 19428408 19435234 dbVar chr22:19344390-19544397 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 70.45 -2.53806827104914 -2.53125239294469 -2.47162789907313 0.128056348383697 0.836381939603491 128977 9 1.9976e-05 3.6900e-07 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 UFD1 NM_005659 7 19437433 19466716 29283 924 100 no 12 txStart-txEnd 5'UTR-3'UTR 19437433 19466716 dbVar chr22:19344390-19544397 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 724954;724955;724956;768151 gain;loss 7353 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CDC45 NM_001178010 2 19467348 19508135 40787 1797 100 no 20 txStart-txEnd 5'UTR-3'UTR 19467348 19508135 dbVar:nssv15124515 22:19470352-19481849 7 Meier-Gorlin_syndrome_7 dbVar chr22:19344390-19544397 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 768153;724957 loss 8.4 -2.57292784443109 -2.53125239294469 -2.47162789907313 0.554183575869215 1.2901097836858 Meier-Gorlin syndrome;Meier-Gorlin syndrome 7 AD;AR Definitive;Strong;Supportive 11416137;121376;149250;27374770;27374770[PMID];282832;30986546 8318 603465 Meier-Gorlin syndrome 7, 617063 (3) AR AR 3 4.6237e-05 6.9104e-02 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CLDN5 NM_001130861 1 19510546 19512860 2314 912 52 no 1 txStart-txEnd 5'UTR-3'UTR 19510546 19512860 1 CLDN5-related_neurodevelopmental_disorder dbVar chr22:19344390-19544397 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 50.93 2.94244265911253 3.34022892264706 7122 1 8.9512e-01 7.4052e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC00895 NR_024381 1 19553652 19554362 710 0 0 no 1 txStart-txEnd UTR 19553652 19554362 dbVar chr22:19531786-19559055;chr22:19531786-19666087 0.01 dbVar chr22:18934999-21466000;chr22:19528613-19558447;chr22:19531786-19559055 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 150185 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SEPTIN5 NM_002688 6 19702025 19710842 8817 1110 100 no 12 txStart-txEnd 5'UTR-3'UTR 19702025 19710842 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 5413 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SEPT5-GP1BB NR_037611 1 19704742 19712297 7555 0 0 no 12 txStart-txEnd UTR 19704742 19712297 Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR dbVar:nssv17977042;morbid:GP1BB 22:19711062-19712294;22:19711829-19711877 9 Bernard_Soulier_syndrome;Macrothrombocytopenia;Mild_macrothrombocytopenia;Thrombocytopenia dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GP1BB NM_000407 5 19711061 19712294 1233 621 100 no 2 txStart-txEnd 5'UTR-3'UTR 19711061 19712294 Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR dbVar:nssv17977042;morbid:GP1BB 22:19711062-19712294;22:19711829-19711877 9 Bernard_Soulier_syndrome;Macrothrombocytopenia;Mild_macrothrombocytopenia;Thrombocytopenia dbVar chr22:19707371-19866503;chr22:19710000-19716000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 30 78.01 -0.00224146961144303 0.855158778511627 Bernard-Soulier syndrome;autosomal dominant macrothrombocytopenia AD;AR Definitive;Strong;Supportive 10887115;12447957;15213102;18825380;19484238;22886561[PMID];23995613;28064200[PMID] 2812 138720 Bernard-Soulier syndrome, type B, 231200 (3) AR;Giant platelet disorder, isolated, 231200 (3) AR AR yes 7 5.1249e-01 1.0112e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TBX1 NM_001379200 1 19748300 19754857 6557 1515 100 no 7 txStart-txEnd 5'UTR-3'UTR 19748300 19754857 Conotruncal anomaly face syndrome, 217095 (3);DiGeorge syndrome, 188400 (3) AD;Tetralogy of Fallot, 187500 (3) AD;Velocardiofacial syndrome, 192430 (3) AD;|DiGeorge_syndrome CLN:959024;morbid:TBX1 22:19748301-19754857;22:19748451-19748647 21 DiGeorge_syndrome;Inborn_genetic_diseases;Velocardiofacial_syndrome dbVar chr22:19707371-19866503 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 2 0 4.92 -2.62354415217069 -2.53125239294469 -2.47162789907313 2.36782594176173 3.38001100960461 22q11.2 deletion syndrome;DiGeorge syndrome;conotruncal heart malformations;velocardiofacial syndrome AD Definitive;Strong;Supportive 11239417;11242049;11242110;11748311;14585638;14585638[PMID];18636631;192430;20054531;20937753;24637876;24998776;25860641;29500247 6899 602054 Conotruncal anomaly face syndrome, 217095 (3);DiGeorge syndrome, 188400 (3) AD;Tetralogy of Fallot, 187500 (3) AD;Velocardiofacial syndrome, 192430 (3) AD AD yes 2 8.3661e-01 9.8340e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GNB1L NM_053004 3 19770745 19842397 71652 984 100 no 8 txStart-txEnd 5'UTR-3'UTR 19770745 19842397 dbVar chr22:19707371-19866503 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 724966;344529;950816;951023;951040;951043 loss;gain 48.57 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.373621593221624 0.590344002361273 54584 5 4.7419e-05 1.2635e-03 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RTL10 NM_024627 6 19833668 19842397 8729 1095 82 no 3 txStart-txEnd 5'UTR-3'UTR 19833668 19842397 dbVar chr22:19707371-19866503;chr22:19821999-20108150 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 79680 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TXNRD2 NM_006440 5 19863044 19929341 66297 1575 100 no 18 txStart-txEnd 5'UTR-3'UTR 19863044 19929341 dbVar chr22:19821999-20108150 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 979497;98439;98826;98831;485936;367919;1066921;778842;1068069;1064219;724968;724969 gain;loss 72.21 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.348188483468328 0.327140414338646 dilated cardiomyopathy;familial glucocorticoid deficiency;familial isolated dilated cardiomyopathy;glucocorticoid deficiency 5 AD;AR Limited;Supportive 21247928[PMID];24601690[PMID];30237576;32476818 10587 606448 ?Glucocorticoid deficiency 5, 617825 (3) AR AR yes 5 3.4688e-11 1.0692e-08 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 COMT NM_000754 4 19929294 19957498 28204 816 100 no 6 txStart-txEnd 5'UTR-3'UTR 19929294 19957498 1 Bardet-Biedl_syndrome dbVar chr22:19821999-20108150 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 1059497;1060872;1060985;1067989;1061244;1070187;1070348;1074180;1064577;1067754;1069000;1071230;1071315;1065708;1070037;1070098;1074085;1070821;290501;257442 loss;gain 40.8 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.465852147917107 0.557839148920189 paroxysmal dyskinesia AD Moderate 1312 116790 (Panic disorder, susceptibility to), 167870 (3) ?AD;(Schizophrenia, susceptibility to), 181500 (3) AD ?AD;AD yes 8 1.1377e-06 8.4666e-04 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR4761 NR_039918 1 19951275 19951357 82 0 0 no 1 txStart-txEnd UTR 19951275 19951357 dbVar chr22:19821999-20108150 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 100616414 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ARVCF NM_001670 3 19957418 20004346 46928 2889 100 no 20 txStart-txEnd 5'UTR-3'UTR 19957418 20004346 dbVar chr22:19821999-20108150 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 871048;393084;393085;35010;35386;44709;498907;263488;847960;20575 gain;loss 54.56 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.425870777992255 -0.701931719398633 421 4 5.0422e-11 8.2184e-07 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TANGO2 NM_001322141 2 20008632 20054687 46055 1110 100 no 9 txStart-txEnd 5'UTR-3'UTR 20008632 20054687 Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, 616878 (3) AR;Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome|Cardiac_arrhythmia|Seizure|Acute_rhabdomyolysis|Episodic_flaccid_weakness|Intellectual_disability HP:0000730;HP:0001249;HP:0001250;HP:0001267;HP:0001275;HP:0001286;HP:0001303;HP:0001656;HP:0001661;HP:0001665;HP:0001666;HP:0001687;HP:0001721;HP:0002122;HP:0002125;HP:0002182;HP:0002192;HP:0002279;HP:0002306;HP:0002316;HP:0002348;HP:0002382;HP:0002386;HP:0002391;HP:0002402;HP:0002417;HP:0002430;HP:0002431;HP:0002432;HP:0002434;HP:0002437;HP:0002458;HP:0002466;HP:0002479;HP:0002482;HP:0002499;HP:0002543;HP:0002794;HP:0003752;HP:0003767;HP:0004351;HP:0005158;HP:0006833;HP:0006997;HP:0007154;HP:0007176;HP:0007180;HP:0008942;HP:0010520;HP:0011675 CLN:226591;dbVar:nssv15770877;dbVar:nssv15772938;nssv15773614;nssv15775115;nssv15775184;nssv15775592;dbVar:nssv15772982;dbVar:nssv15775129;dbVar:nssv16216543;dbVar:nssv17171772;dbVar:nssv17971094;dbVar:nssv18790095;dbVar:nssv8639589;nssv15122532;morbid:TANGO2 22:20008633-20054687;22:20028564-20053554;22:20030823-20041691;22:20030823-20053554;22:20030859-20052185;22:20030879-20049206;22:20030879-20052185;22:20036383-20045782;22:20036384-20045781;22:20036385-20045784;22:20039969-20043556 16 Abnormality_of_metabolism/homeostasis;Acute_rhabdomyolysis;Cardiac_arrhythmia;Episodic_flaccid_weakness;Inborn_genetic_diseases;Intellectual_disability;Metabolic_crises_with_rhabdomyolysis,_cardiac_arrhythmias,_and_neurodegeneration;Recurrent_metabolic_encephalomyopathic_crises-rhabdomyolysis-cardiac_arrhythmia-intellectual_disability_syndrome;Seizure dbVar chr22:19821999-20108150;chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 545395;290503;301777;286870;290504 loss;gain 51.91 -2.62354415217069 -2.53125239294469 -2.47162789907313 1.46130508236304 0.279301120222081 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration;recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome AR Moderate;Strong 26805781;26805782 128989 616830 Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration, 616878 (3) AR AR yes 4 1.4769e-04 4.2224e-06 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR185 NR_029706 1 20020661 20020743 82 0 0 no 1 txStart-txEnd UTR 20020661 20020743 dbVar chr22:19821999-20108150;chr22:19973106-20124645;chr22:20015350-20023000 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 406961 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR8 NM_022720 7 20067763 20099395 31632 2322 100 no 14 txStart-txEnd 5'UTR-3'UTR 20067763 20099395 dbVar chr22:19821999-20108150;chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 768159 loss 5.07 -2.46581011772843 -2.53125239294469 -2.47162789907313 0.690563071344625 4.03153091509844 54487 0 9.9973e-01 9.9990e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR3618 NR_037412 1 20073268 20073356 88 0 0 no 1 txStart-txEnd UTR 20073268 20073356 dbVar chr22:19821999-20108150;chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 100500860 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR1306 NR_031706 1 20073580 20073665 85 0 0 no 1 txStart-txEnd UTR 20073580 20073665 dbVar chr22:19821999-20108150;chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 100302197 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TRMT2A NM_001331039 2 20099397 20104749 5352 1932 100 no 12 txStart-txEnd 5'UTR-3'UTR 20099397 20104749 dbVar chr22:19821999-20108150;chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 68.23 -2.62354415217069 -2.53125239294469 -2.47162789907313 -1.98609532754524 -0.363927890852326 27037 5 1.0841e-08 1.3059e-05 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR6816 NR_106874 1 20102208 20102274 66 0 0 no 1 txStart-txEnd UTR 20102208 20102274 dbVar chr22:19821999-20108150;chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 102465490 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RANBP1 NM_001278639 2 20103626 20114878 11252 837 100 no 6 txStart-txEnd 5'UTR-3'UTR 20103626 20114878 dbVar chr22:19973106-20124645 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 724972 loss 8.76 -2.62354415217069 -2.53125239294469 -2.47162789907313 -1.04492215962902 2.06932219421127 5902 2 8.2235e-01 3.3622e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SNORA77B NR_145765 1 20113924 20114049 125 0 0 no 1 txStart-txEnd UTR 20113924 20114049 dbVar chr22:19973106-20124645;chr22:20109000-20115000;chr22:20112900-20120550 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 109617010 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ZDHHC8 NM_001185024 2 20119326 20135530 16204 2337 100 no 11 txStart-txEnd 5'UTR-3'UTR 20119326 20135530 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 768162 loss 37.82 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.408428770523539 2.39258092860216 29801 1 8.5288e-01 9.8899e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CCDC188 NM_001365892 2 20135938 20138578 2640 1209 100 no 9 txStart-txEnd 5'UTR-3'UTR 20135938 20138578 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 388849 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC02891 NR_038460 2 20186251 20192441 6190 0 0 no 4 txStart-txEnd UTR 20186251 20192441 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 284865 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC00896 NR_026919 1 20193854 20196060 2206 0 0 no 1 txStart-txEnd UTR 20193854 20196060 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 150197 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RTN4R NM_023004 6 20228937 20255841 26904 1422 100 no 2 txStart-txEnd 5'UTR-3'UTR 20228937 20255841 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 35.77 -0.800223805913347 1.18081437151802 65078 605566 (Schizophrenia, susceptibility to), 181500 (3) AD AD yes 1 9.5882e-01 5.2644e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR1286 NR_031618 1 20236656 20236734 78 0 0 no 1 txStart-txEnd UTR 20236656 20236734 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:18904624-20296851;22:18939719-20275949;22:18954422-20259184;22:18957903-20255847;22:19014638-21718005 0.4801 100302118 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 DGCR6L NM_033257 4 20301760 20307583 5823 663 100 no 5 txStart-txEnd 5'UTR-3'UTR 20301760 20307583 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 79.33 0.698499439551705 0.174075190759776 85359 7 5.0636e-05 1.2857e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM230A NR_165629 1 20326419 20350461 24042 0 0 no 12 txStart-txEnd UTR 20326419 20350461 DDD:56225;DDD:56226;dbVar chr22:20310677-20370753;chr22:20310677-20503817;22:20313251-20369884;22:20322450-20718598 0.0509 DDD:56225;DDD:56226;dbVar chr22:18934999-21466000;22:20313251-20369884;22:20322450-20718598 0.0959 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 97.89 653203 7 4.8065e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 GGTLC3 NM_001355479 1 20366210 20368028 1818 678 100 no 6 txStart-txEnd 5'UTR-3'UTR 20366210 20368028 DDD:56225;DDD:56226;DDD:56232;DDD:56234;dbVar;gnomAD-SV_v2.1_DUP_22_50780 chr22:20310677-20370753;chr22:20310677-20503817;22:20313251-20369884;22:20322450-20718598;22:20330330-20450295;22:20333000-20381150;22:20343574-20380608 0.0620 DDD:56225;DDD:56226;DDD:56232;DDD:56234;dbVar chr22:18934999-21466000;22:20313251-20369884;22:20322450-20718598;22:20330330-20450295;22:20343574-20380608 0.0959 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 94.16 728226 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TMEM191B NM_001242313 1 20377668 20380440 2772 1041 100 no 9 txStart-txEnd 5'UTR-3'UTR 20377668 20380440 DDD:56226;DDD:56232;DDD:56234;dbVar;gnomAD-SV_v2.1_DUP_22_50780 chr22:20310677-20503817;22:20322450-20718598;22:20330330-20450295;22:20333000-20381150;22:20343574-20380608;chr22:20370753-20489646;chr22:20370753-20503717 0.0620 DDD:56226;DDD:56232;DDD:56234;dbVar chr22:18934999-21466000;22:20322450-20718598;22:20330330-20450295;22:20343574-20380608;chr22:20366424-20403000;chr22:20374000-20389000 0.0284 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 728229 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 PI4KAP1 NR_003563 1 20383730 20398695 14965 0 0 no 15 txStart-txEnd UTR 20383730 20398695 DDD:56226;DDD:56232;dbVar chr22:20310677-20503817;22:20322450-20718598;22:20330330-20450295;chr22:20370753-20489646;chr22:20370753-20503717 0.0509 DDD:56226;DDD:56232;dbVar chr22:18934999-21466000;22:20322450-20718598;22:20330330-20450295;chr22:20366424-20403000 0.0189 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 728233 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 RIMBP3 NM_015672 2 20455681 20461786 6105 4920 91 no 1 txStart-txEnd 5'UTR-3'UTR 20455681 20461786 DDD:56226;dbVar;gnomAD-SV_v2.1_DUP_22_50781 chr22:20310677-20503817;22:20322450-20718598;chr22:20370753-20489646;chr22:20370753-20503717;22:20451000-20466000 0.1528 DDD:56226;HI40:ISCA-46728;dbVar;dgv817e199 chr22:18934999-21466000;22:20322450-20718598;22:20423846-20488792;22:20428071-20499197 0.0300 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 90.21 85376 7 9.0005e-09 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM246B NM_001396026 1 20483850 20484549 699 699 100 no 1 txStart-txEnd 5'UTR-3'UTR 20483850 20484549 DDD:56226;dbVar;gnomAD-SV_v2.1_DUP_22_50783 chr22:20310677-20503817;22:20322450-20718598;chr22:20370753-20489646;chr22:20370753-20503717;chr22:20465500-20509200;22:20483000-20490000 0.2000 DDD:56226;HI40:ISCA-46728;dbVar;dgv817e199 chr22:18934999-21466000;22:20322450-20718598;22:20423846-20488792;22:20428071-20499197 0.0300 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 117134597 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM230J NR_136569 2 20632119 20656858 24739 0 0 no 9 txStart-txEnd UTR 20632119 20656858 DDD:56226;dbVar 22:20322450-20718598;chr22:20610555-20718305 0.0509 DDD:56226;dbVar chr22:18934999-21466000;22:20322450-20718598 0.0118 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 729461 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 FAM230G NR_165637 1 20689194 20706786 17592 0 0 no 7 txStart-txEnd UTR 20689194 20706786 DDD:56226;DDD:56255;dbVar 22:20322450-20718598;chr22:20610555-20718305;22:20659548-20717455 0.0509 DDD:56226;DDD:56255;dbVar chr22:18934999-21466000;22:20322450-20718598;22:20659548-20717455 0.0604 IMH 22:17036164-22613666;22:18655109-20719124;22:19014638-21718005 0.1686 101927859 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 ZNF74 NM_001256524 2 20748440 20762745 14305 1935 100 no 6 txStart-txEnd 5'UTR-3'UTR 20748440 20762745 dbVar chr22:20722999-20763000;chr22:20746552-20846353;chr22:20747116-20782223 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005 0.1686 86.28 -1.30437956536809 -1.89912490049618 -1.51976012533128 2.28676628831896 2.39892044394279 7625 4 1.5586e-06 3.5588e-04 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SCARF2 NM_153334 7 20778873 20792112 13239 2607 100 no 14 txStart-txEnd 5'UTR-3'UTR 20778873 20792112 Van den Ende-Gupta syndrome, 600920 (3) AR morbid:SCARF2 22:20778874-20792112 3 Van_den_Ende-Gupta_syndrome dbVar chr22:20746552-20846353;chr22:20763251-20802665 0.01 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005 0.1686 342985;1011827;329413;334666 gain;loss 30 0 70.17 -1.42333559636086 -1.93669033911618 -1.61173791689534 van den Ende-Gupta syndrome AR Definitive;Limited;Moderate;Strong;Supportive 20887961;20887961[PMID]_22140376[PMID];21108395;22140376;23808541;24478002;3808541 91179 613619 Van den Ende-Gupta syndrome, 600920 (3) AR AR yes 0 9.9980e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 KLHL22 NM_032775 4 20795805 20850082 54277 1905 100 no 7 txStart-txEnd 5'UTR-3'UTR 20795805 20850082 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005 0.1686 724981;568169;724982;724983;724984;724985;724986;724987 gain;loss 41.2 -1.60479766897668 -1.94085802577819 -1.599983320827 -0.00460568166698648 2.85964800561254 84861 2 4.2419e-01 7.0261e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MED15 NM_001003891 3 20861896 20941906 80010 2367 100 no 18 txStart-txEnd 5'UTR-3'UTR 20861896 20941906 dbVar chr22:18934999-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005 0.1686 24.41 0.672972182845271 2.65389095774821 51586 0 9.9974e-01 9.6081e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 POM121L4P NR_024592 1 21043842 21046009 2167 0 0 no 1 txStart-txEnd UTR 21043842 21046009 dbVar chr22:20989999-21481000;chr22:21036802-21046081;chr22:21036802-21053355;chr22:21037000-21051000 0.01 dbVar chr22:18934999-21466000;chr22:21027000-21048000 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 266697 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TMEM191A NR_026815 1 21055401 21058891 3490 0 0 no 8 txStart-txEnd UTR 21055401 21058891 dbVar chr22:20989999-21481000;chr22:21051000-21059000 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 84222 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 PI4KA NM_058004 4 21061978 21213099 151121 6309 100 no 55 txStart-txEnd 5'UTR-3'UTR 21061978 21213099 Gastrointestinal defects and immunodeficiency syndrome 2, 619708 (3) AR;Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis, 616531 (3) AR;Spastic paraplegia 84, AR, 619621 (3) AR;Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD morbid:PI4KA;morbid:SERPIND1 22:21061979-21213099;22:21128401-21142008 8 PI4KA-Related_Disorders;Polymicrogyria,_perisylvian,_with_cerebellar_hypoplasia_and_arthrogryposis;Spastic_paraplegia_84,_autosomal_recessive dbVar chr22:20989999-21481000 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 513199;263494;724990;724991;768172;768173;1061246;1068660;1060873;1070188;1065051;1068661;1073865;1068662;1069644;1066059;724992;724993;367925;2069010;724994;724995;75440 loss;gain 35.17 1.20573288011437 5.29477062168781 polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis AR Definitive;Moderate;Strong 25855803;29738522;30614210;34415310;34415322 5297 600286 Gastrointestinal defects and immunodeficiency syndrome 2, 619708 (3) AR;Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis, 616531 (3) AR;Spastic paraplegia 84, AR, 619621 (3) AR AR yes 2 3.1234e-12 8.0407e-04 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SERPIND1 NM_000185 4 21128400 21142008 13608 1500 100 no 5 txStart-txEnd 5'UTR-3'UTR 21128400 21142008 Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD morbid:SERPIND1 22:21128401-21142008 dbVar chr22:20989999-21481000;chr22:21078735-21159481 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21078735-21159481 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 724992;724993 loss 68.88 -1.06265755233802 -1.49456297636655 -1.03231231326932 -0.289055396385536 -0.349034099945665 heparin cofactor 2 deficiency AD Definitive;Limited;Strong 15337701;2647747;277130;8562924 3053 142360 Thrombophilia 10 due to heparin cofactor II deficiency, 612356 (3) AD AD yes 8 2.5137e-10 2.7955e-05 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SNAP29 NM_004782 4 21213294 21245502 32208 777 100 no 5 txStart-txEnd 5'UTR-3'UTR 21213294 21245502 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR morbid:SNAP29 22:21213295-21245502 10 CEDNIK_syndrome;Hypomyelinating_leukodystrophy_2 dbVar chr22:20989999-21481000 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 30 61.36 -1.39880243235913 -1.53414994058354 -1.19910660480315 1.58078637399342 -0.841707455415557 CEDNIK syndrome AR Strong;Supportive 15968592;15968592[PMID]_21073448[PMID];21073448;23231787;25473036;26747696 9342 604202 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, 609528 (3) AR AR yes 4 1.3567e-02 1.5166e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 CRKL NM_005207 4 21271694 21308035 36341 912 100 no 3 txStart-txEnd 5'UTR-3'UTR 21271694 21308035 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 687520;325941 gain 1 0 4.35 -0.928255048107525 -1.20830830104818 -0.791505674827999 0.477351976371369 3.00980268645085 1399 3 4.4604e-01 1.6345e-01 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LINC01637 NR_110537 1 21311379 21318968 7589 0 0 no 2 txStart-txEnd UTR 21311379 21318968 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 101928891 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 AIFM3 NM_144704 3 21319459 21335647 16188 1818 100 no 21 txStart-txEnd 5'UTR-3'UTR 21319459 21335647 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 38.59 -1.14442881641699 -1.26664892202732 -0.922844550293754 0.687283106386744 1.33036583543754 150209 5 1.9474e-14 1.9583e-10 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LZTR1 NM_006767 4 21336585 21353321 16736 2523 100 no 21 txStart-txEnd 5'UTR-3'UTR 21336585 21353321 Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;Schwannomatosis-2, susceptibility to, 615670 (3) AD CLN:2871255;dbVar:nssv17171582;dbVar:nssv17971092;morbid:LZTR1 22:21336586-21353321;22:21336662-21337398;22:21336662-21351637;22:21348908-21348985 CLN:1349334;dbVar:nssv17974796 22:21337344-21337343;22:21337344-21337456 287 Autism_spectrum_disorder;Cardiovascular_phenotype;Fetal_cystic_hygroma;Hereditary_cancer-predisposing_syndrome;Inborn_genetic_diseases;LZTR1-related_condition;LZTR1-related_disorders;Noonan_syndrome;Noonan_syndrome_10;Noonan_syndrome_2;Noonan_syndrome_and_Noonan-related_syndrome;RASopathy;Schwannomatosis;Schwannomatosis_2;See_cases;Short_stature dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 687522 gain 32.82 -1.25119505668143 -1.28020537251329 -0.946080819110286 0.246895000414255 0.909128978651125 Noonan syndrome;Noonan syndrome 10;Noonan syndrome 2;schwannomatosis 2 AD;AR Definitive;Moderate;Strong;Supportive 15955931;16534111;23401320;24362817;25335493;25480913;25795793;25795793[PMID];26446362;274799;278971;287232;29469822;30368668;303983;30442762;30442766;30481304;30664951;30859559;31533111;31825158 8216 600574 Noonan syndrome 10, 616564 (3) AD;Noonan syndrome 2, 605275 (3) AR;(Schwannomatosis-2, susceptibility to), 615670 (3) AD AD;AR yes yes 9 1.0211e-92 3.3832e-52 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 THAP7 NM_030573 3 21353392 21356407 3015 930 100 no 4 txStart-txEnd 5'UTR-3'UTR 21353392 21356407 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 50.87 -1.44618961523547 -1.52989215323949 -1.19895133869269 -1.50983365445593 1.16392737773964 80764 4 1.3291e-02 2.9328e-02 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 THAP7-AS1 NR_027051 1 21356210 21364663 8453 0 0 no 2 txStart-txEnd UTR 21356210 21364663 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 439931 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 TUBA3FP NR_003608 1 21362491 21368576 6085 0 0 no 3 txStart-txEnd UTR 21362491 21368576 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776;chr22:21358356-21370047;chr22:21360600-21369738 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 113691 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 P2RX6 NM_001394691 1 21369453 21382297 12844 1422 100 no 12 txStart-txEnd 5'UTR-3'UTR 21369453 21382297 dbVar chr22:20989999-21481000;chr22:21256865-21435776 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 724998 loss 76.26 -1.8606303493434 -1.51336493990188 -1.2805127161158 -0.990180484365383 -0.63060581685217 9127 6 4.4680e-09 1.8785e-07 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 SLC7A4 NM_004173 3 21383006 21386850 3844 1908 100 no 5 txStart-txEnd 5'UTR-3'UTR 21383006 21386850 dbVar chr22:20989999-21481000;chr22:21256865-21435776;chr22:21372999-21431350 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 74.02 -0.807902299547855 -1.26588610868392 -1.04316708587741 -0.387275128092876 -1.12481109733158 6545 6 2.8317e-07 1.0047e-04 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 MIR649 NR_030379 1 21388464 21388561 97 0 0 no 1 txStart-txEnd UTR 21388464 21388561 dbVar;esv2760719 chr22:20989999-21481000;chr22:21256865-21435776;chr22:21372999-21431350;22:21383283-21845355;chr22:21384000-21389000 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 693234 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 P2RX6P NR_002829 1 21396680 21398538 1858 0 0 no 2 txStart-txEnd UTR 21396680 21398538 dbVar;esv2760719 chr22:20989999-21481000;chr22:21256865-21435776;chr22:21372999-21431350;22:21383283-21845355 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 440799 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 LRRC74B NM_001291006 2 21400234 21418457 18223 1179 100 no 10 txStart-txEnd 5'UTR-3'UTR 21400234 21418457 dbVar;esv2760719 chr22:20989999-21481000;chr22:21256865-21435776;chr22:21372999-21431350;22:21383283-21845355 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21256865-21435776 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 725000 loss 400891 full=5 +22_18894836_21464119_DEL_1 22 18894836 21464119 -2569283 DEL Di George syndrom Pathogenic NA split q11.21 BCRP2 NR_037566 1 21457304 21476575 6815 0 0 no 6 txStart-intron1 UTR 6098 3' 21457304 21464119 dbVar;esv2760719 chr22:20989999-21481000;22:21383283-21845355;chr22:21453999-21469000;chr22:21455959-21464881 0.01 dbVar chr22:18934999-21466000;chr22:21052000-21466000;chr22:21455959-21464881;chr22:21456000-21467000 0.01 IMH 22:17036164-22613666;22:19014638-21718005;22:21042853-21483407 0.1686 400892 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA full p16.1-p16.3 ZNF595;ZNF718;ZNF876P;ZNF732;ZNF141;MIR571;ABCA11P;ZNF721;PIGG;TMEM271;LOC105374338;PDE6B;ATP5ME;MYL5;SLC49A3;PCGF3;PCGF3-AS1;CPLX1;GAK;TMEM175;DGKQ;SLC26A1;IDUA;FGFRL1;RNF212;LOC105374344;TMED11P;SPON2;LOC100130872;CTBP1-AS;CTBP1;CTBP1-DT;MAEA;UVSSA;NKX1-1;FAM53A;SLBP;TMEM129;TACC3;FGFR3;LETM1;NSD2;SCARNA22;NELFA;MIR943;C4orf48;NAT8L;POLN;HAUS3;MXD4;MIR4800;ZFYVE28;CFAP99;RNF4;FAM193A;TNIP2;SH3BP2;ADD1;MFSD10;NOP14-AS1;NOP14;GRK4;HTT-AS;HTT;MSANTD1;RGS12;HGFAC;DOK7;LRPAP1;LINC00955;LINC02171;ADRA2C;FAM86EP;OTOP1;TMEM128;LYAR;ZBTB49;NSG1;STX18;STX18-IT1;STX18-AS1;SNORD162;LOC101928279;LINC01396;MSX1;LOC101928306;CYTL1;STK32B;LINC01587;EVC2;EVC;CRMP1;MIR378D1;C4orf50;JAKMIP1;JAKMIP1-DT;WFS1;PPP2R2C;MAN2B2;MRFAP1;LINC02482;LOC93622;LINC02481;S100P;MRFAP1L1;BLOC1S4;KIAA0232;TBC1D14;LOC100129931;CCDC96;TADA2B;GRPEL1;LINC02447;SORCS2;MIR4798;PSAPL1;MIR4274;AFAP1-AS1;AFAP1;LOC389199;ABLIM2;MIR95;SH3TC1;HTRA3;LINC02517;ACOX3;TRMT44;GPR78;CPZ;HMX1;FAM90A26;USP17L10;USP17L11;USP17L12;USP17L13;USP17L15;USP17L17;USP17L18;USP17L19;USP17L20;USP17L21;USP17L22;USP17L24;USP17L25;USP17L26;USP17L5;USP17L27;USP17L28;USP17L29;USP17L9P;USP17L30;USP17L6P DEFB131A 152 ACACA (morbid/RE=mTL_miRNA);ACTC1 (morbid/RE=mTL_miRNA);ACVR1 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AKT1 (morbid/RE=mTL_miRNA);ANTXR2 (morbid/RE=mTL_miRNA);ARF1 (morbid/RE=mTL_miRNA);ARHGDIA (morbid/RE=mTL_miRNA);ARPC1B (morbid/RE=mTL_miRNA);ATXN2 (morbid/RE=mTL_miRNA);CAD (morbid/RE=mTL_miRNA);CALM2 (morbid/RE=mTL_miRNA);CASK (morbid/RE=mTL_miRNA);CCNF (morbid/RE=mTL_miRNA);CELF2 (morbid/RE=mTL_miRNA);CEP55 (morbid/RE=mTL_miRNA);CIITA (morbid/RE=mTL_miRNA);CNTNAP2 (morbid/RE=mTL_miRNA);COL18A1 (morbid/RE=mTL_miRNA);COL1A1 (HI=3/morbid/RE=mTL_miRNA);CREBBP (HI=3/morbid/RE=mTL_miRNA);CTCF (HI=3/morbid/RE=mTL_miRNA);DAAM2 (morbid/RE=mTL_miRNA);DDR2 (morbid/RE=mTL_miRNA);DDX3X (HI=3/morbid/RE=mTL_miRNA);EDEM3 (morbid/RE=mTL_miRNA);EGLN1 (morbid/RE=mTL_miRNA);ELOVL5 (morbid/RE=mTL_miRNA);ESCO2 (morbid/RE=mTL_miRNA);FLCN (HI=3/morbid/RE=mTL_miRNA);FLVCR1 (morbid/RE=mTL_miRNA);FOXC1 (HI=3/morbid/RE=mTL_miRNA);FOXP2 (morbid/RE=mTL_miRNA);G6PD (morbid/RE=mTL_miRNA);GABRB2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GLI2 (HI=3/morbid/RE=mTL_miRNA);GLUL (morbid/RE=mTL_miRNA);GNAS (HI=3/morbid/RE=mTL_miRNA);HERC2 (morbid/RE=mTL_miRNA);HFE (morbid/RE=mTL_miRNA);IGF1R (HI=3/morbid/RE=mTL_miRNA);INF2 (morbid/RE=mTL_miRNA);ITM2B (morbid/RE=mTL_miRNA);KCNJ6 (morbid/RE=mTL_miRNA);LAMA4 (morbid/RE=mTL_miRNA);LMNB2 (morbid/RE=mTL_miRNA);LRP6 (morbid/RE=mTL_miRNA);MCTS1 (morbid/RE=mTL_miRNA);MED13 (morbid/RE=mTL_miRNA);MEN1 (HI=3/morbid/RE=mTL_miRNA);MMADHC (morbid/RE=mTL_miRNA);MOCS2 (morbid/RE=mTL_miRNA);MRAS (morbid/RE=mTL_miRNA);MYRF (morbid/RE=mTL_miRNA);NCKAP1 (HI=3/RE=mTL_miRNA);NDST1 (morbid/RE=mTL_miRNA);NOTCH2 (morbid/RE=mTL_miRNA);NUP93 (morbid/RE=mTL_miRNA);OCRL (HI=3/morbid/RE=mTL_miRNA);P4HB (morbid/RE=mTL_miRNA);PEX10 (morbid/RE=mTL_miRNA);PLAA (morbid/RE=mTL_miRNA);PNPO (morbid/RE=mTL_miRNA);PRNP (morbid/RE=mTL_miRNA);PRPF6 (morbid/RE=mTL_miRNA);PUM1 (morbid/RE=mTL_miRNA);RAD51 (morbid/RE=mTL_miRNA);RAI1 (HI=3/morbid/RE=mTL_miRNA);RAP1B (morbid/RE=mTL_miRNA);REL (morbid/RE=mTL_miRNA);REST (morbid/RE=mTL_miRNA);RLIM (morbid/RE=mTL_miRNA);SAMD12 (morbid/RE=mTL_miRNA);SCD (morbid/RE=mTL_miRNA);SDHD (HI=3/morbid/RE=mTL_miRNA);SET (morbid/RE=mTL_miRNA);SF1 (morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC1A4 (morbid/RE=mTL_miRNA);SLC25A46 (morbid/RE=mTL_miRNA);SLC27A4 (morbid/RE=mTL_miRNA);SLC2A9 (morbid/RE=ABC_enhancer);SLC6A6 (morbid/RE=mTL_miRNA);SOX4 (morbid/RE=mTL_miRNA);SREBF1 (morbid/RE=mTL_miRNA);SUZ12 (morbid/RE=mTL_miRNA);TBX18 (morbid/RE=mTL_miRNA);TBX20 (morbid/RE=mTL_miRNA);TGFB2 (morbid/RE=mTL_miRNA);TRIP13 (morbid/RE=mTL_miRNA);TRIP4 (morbid/RE=mTL_miRNA);TUBB2A (morbid/RE=mTL_miRNA);USP48 (morbid/RE=mTL_miRNA);USP8 (morbid/RE=mTL_miRNA);WDR1 (morbid/RE=ABC_enhancer);WDR35 (morbid/RE=mTL_miRNA);WDR45B (morbid/RE=mTL_miRNA);YY1 (morbid/RE=mTL_miRNA);ZC3H14 (morbid/RE=mTL_miRNA);ZNF699 (morbid/RE=mTL_miRNA);ZNF711 (morbid/RE=mTL_miRNA) Retinitis_pigmentosa|Retinitis_pigmentosa_40 HP:0000547 CLN:801370;dbVar:nssv15124412;dbVar:nssv15130095;dbVar:nssv15132150;dbVar:nssv15132411;dbVar:nssv15132589;dbVar:nssv15133497;dbVar:nssv15153559;dbVar:nssv15161020;dbVar:nssv16255833;dbVar:nssv16867404;dbVar:nssv17172169;dbVar:nssv17973849;dbVar:nssv18330201 4:127234-8667610;4:1420949-1836794;4:1737489-1808653;4:1770487-2303110;4:374558-745174;4:5567009-5587839;4:5785270-5803831;4:614356-2959936;4:619584-619584;4:619590-619662;4:72448-3848881;4:72448-5608810;4:85041-4597934;4:963689-2913553 4p16.3 terminal (Wolf-Hirschhorn syndrome) region;?Cataract 41, 116400 (3) AD;Deafness, AD 6;14;38, 600965 (3) AD;Wolfram syndrome 1, 222300 (3) AR;Wolfram-like syndrome, AD, 614296 (3) AD;Diabetes mellitus, noninsulin-dependent, association with, 125853 (3) AD;?Spermatogenic failure 62, 619673 (3) AR;Recombination rate QTL 1, 612042 (3);?Weyers acrofacial dysostosis, 193530 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR;Achondroplasia, 100800 (3) AD;Bladder cancer, somatic, 109800 (3);CATSHL syndrome, 610474 (3) AR,AD;Cervical cancer, somatic, 603956 (3);Colorectal cancer, somatic, 114500 (3);Crouzon syndrome with acanthosis nigricans, 612247 (3) AD;Hypochondroplasia, 146000 (3) AD;LADD syndrome 2, 620192 (3) AD;Muenke syndrome, 602849 (3) AD;Nevus, epidermal, somatic, 162900 (3);SADDAN, 616482 (3) AD;Spermatocytic seminoma, somatic, 273300 (3);Thanatophoric dysplasia, type I, 187600 (3) AD;Thanatophoric dysplasia, type II, 187601 (3) AD;Cherubism, 118400 (3) AD;Curry-Hall_syndrome|Ellis-van_Creveld_syndrome;Developmental and epileptic encephalopathy 63, 617976 (3) AR;Ectodermal dysplasia 3, Witkop type, 189500 (3) AD;Orofacial cleft 5, 608874 (3) AD;Tooth agenesis, selective, 1, with or without orofacial cleft, 106600 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR;Weyers acrofacial dysostosis, 193530 (3) AD;Fetal akinesia deformation sequence 3, 618389 (3) AR;Myasthenic syndrome, congenital, 10, 254300 (3) AR;Huntington disease, 143100 (3) AD;Lopes-Maciel-Rodan syndrome, 617435 (3) AR;Hurler_syndrome;Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome, 617915 (3) AD;Mucopolysaccharidosis Ih, 607014 (3) AR;Mucopolysaccharidosis Ih;s, 607015 (3) AR;Mucopolysaccharidosis Is, 607016 (3) AR;Mucopolysaccharidosis_type_1;Myopia 23, AR, 615431 (3) AR;Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction, 620089 (3) AR;Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy, 616917 (3) AR;Blood group, EMM system, 619812 (3) AR;Night blindness, congenital stationary, AD 2, 163500 (3) AD;Retinitis pigmentosa-40, 613801 (3) AR;Oculoauricular syndrome, 612109 (3) AR;Rauch-Steindl syndrome, 619695 (3) AD;UV-sensitive syndrome 3, 614640 (3) AR HP:0000943 CLN:1313135;CLN:2672009;CLN:961843;HI3:ISCA-37429;HI3:MSX1;HI3:NSD2;dbVar:nssv15119851;dbVar:nssv15121023;dbVar:nssv15121032;dbVar:nssv15121033;dbVar:nssv15121034;dbVar:nssv15121217;dbVar:nssv15121218;dbVar:nssv15121687;dbVar:nssv15122678;dbVar:nssv15123516;dbVar:nssv15124520;dbVar:nssv15127349;dbVar:nssv15130945;dbVar:nssv15131476;dbVar:nssv15131910;dbVar:nssv15132407;dbVar:nssv15132408;dbVar:nssv15132580;nssv15140019;dbVar:nssv15132953;dbVar:nssv15133489;dbVar:nssv15133490;dbVar:nssv15133634;dbVar:nssv15134794;dbVar:nssv15134826;dbVar:nssv15135086;dbVar:nssv15135107;dbVar:nssv15138367;dbVar:nssv15138802;dbVar:nssv15138941;dbVar:nssv15139309;dbVar:nssv15144315;dbVar:nssv15147286;dbVar:nssv15153560;dbVar:nssv15153562;dbVar:nssv15605891;dbVar:nssv15606061;dbVar:nssv15770186;dbVar:nssv15770321;dbVar:nssv16211870;dbVar:nssv16212102;dbVar:nssv16213046;dbVar:nssv16213271;dbVar:nssv16213451;dbVar:nssv16213572;dbVar:nssv16213637;dbVar:nssv16213802;dbVar:nssv16214176;dbVar:nssv16214333;dbVar:nssv16216714;dbVar:nssv16252200;dbVar:nssv16253953;dbVar:nssv16254938;dbVar:nssv16297119;dbVar:nssv16297131;dbVar:nssv16867405;dbVar:nssv17171362;dbVar:nssv17171376;dbVar:nssv17171391;dbVar:nssv17171923;dbVar:nssv17172168;dbVar:nssv17172572;dbVar:nssv17172573;dbVar:nssv17172574;dbVar:nssv17172955;dbVar:nssv17173143;dbVar:nssv17173159;dbVar:nssv17683620;dbVar:nssv17970729;dbVar:nssv17970732;dbVar:nssv17971217;dbVar:nssv17971266;dbVar:nssv17971361;dbVar:nssv17971686;dbVar:nssv17971734;dbVar:nssv17971799;dbVar:nssv17971904;dbVar:nssv17972056;dbVar:nssv17972166;dbVar:nssv17972432;dbVar:nssv17973718;nssv17974037;dbVar:nssv17973748;dbVar:nssv17974578;dbVar:nssv17975024;dbVar:nssv17976233;dbVar:nssv17976464;dbVar:nssv17976477;dbVar:nssv17976550;dbVar:nssv18326580;dbVar:nssv18786244;dbVar:nssv18786333;dbVar:nssv18787193;dbVar:nssv18788241;dbVar:nssv18788242;dbVar:nssv18788927;dbVar:nssv18788928;dbVar:nssv18790018;dbVar:nssv18790019;dbVar:nssv18790020;dbVar:nssv18790021;dbVar:nssv18790022;dbVar:nssv18790117;dbVar:nssv18790118;dbVar:nssv18790119;dbVar:nssv18790120;dbVar:nssv18790121;dbVar:nssv18790180;dbVar:nssv18790633;dbVar:nssv18791534;dbVar:nssv18791535;dbVar:nssv18791536;dbVar:nssv18791537;dbVar:nssv18791538;dbVar:nssv18791542;dbVar:nssv18830727;morbid:CPLX1;morbid:CTBP1;morbid:DOK7;morbid:EVC;morbid:EVC2;morbid:FGFR3;morbid:HMX1;morbid:HTRA3;morbid:HTT;morbid:IDUA;morbid:LETM1;morbid:LRPAP1;morbid:MSX1;morbid:NSD2;morbid:PDE6B;morbid:PIGG;morbid:RNF212;morbid:SH3BP2;morbid:UVSSA;morbid:WFS1 4:1087097-1107352;4:1190912-2255904;4:1205233-1244143;4:1228529-2862002;4:129754-9371067;4:1305803-2460571;4:1340996-1381837;4:1619776-2181192;4:1701019-1975031;4:1784695-1919793;4:1795020-1810594;4:1813206-1857883;4:1827029-1860753;4:1873124-1983934;4:1902353-1950545;4:1941634-3879802;4:1966267-5913899;4:2009467-3080412;4:2200252-5710240;4:2364202-5447465;4:2820541-2842823;4:2909441-6871516;4:3076408-3245687;4:3085428-7591673;4:331569-2010962;4:3465094-3495238;4:3465104-3465298;4:3475114-3491543;4:3478271-3491403;4:3486271-3496209;4:3487104-3487370;4:3487247-3495248;4:3487257-3487395;4:3487257-3495238;4:3494467-3495228;4:3495083-3495158;4:3505339-3534149;4:3776785-7361544;4:388345-3872380;4:4859066-4864603;4:4861392-4865663;4:4861393-4865663;4:4861628-6304195;4:492999-533989;4:493126-2065854;4:493126-663896;4:493126-998181;4:493969-499930;4:494166-494410;4:499508-502759;4:501175-533158;4:502599-509994;4:507006-2214932;4:509743-533158;4:512203-518547;4:520809-1020391;4:524206-527790;4:5563147-5711294;4:5564166-5711275;4:5564566-5578191;4:5564566-5586587;4:5564566-5759862;4:5564576-5567096;4:5565511-5811251;4:5570162-5570377;4:5576403-5576509;4:5617140-5812774;4:5630277-5633769;4:5630336-5635926;4:5630338-5635927;4:5636440-5710337;4:5642222-5642585;4:5682978-5735172;4:5690875-5691080;4:5690875-5696238;4:5696053-5696238;4:5710004-5750043;4:5711925-5817031;4:5712928-5816032;4:5713109-5714221;4:5713159-5713318;4:5731025-5759862;4:5733143-5735172;4:5749726-5755670;4:5754554-5755670;4:5754554-5758099;4:5754554-5785501;4:5754599-5758602;4:5785270-5812774;4:5795340-5795484;4:5795341-5795483;4:5798730-5798979;4:5798740-5798969;4:5803668-5806578;4:5809919-5811348;4:619417-619883;4:6271577-6304992;4:6279184-6279434;4:629670-670728;4:646966-664571;4:647642-648677;4:651220-652826;4:652722-656427;4:652742-656407;4:660321-661795;4:664193-671649;4:72448-2110334;4:72448-2327204;4:72448-2691306;4:72448-3208040;4:72448-3563382;4:72448-3725774;4:72448-3787112;4:72448-4360445;4:72448-4889835;4:72448-5036718;4:72448-5214111;4:72448-5346537;4:72448-6245152;4:72448-7831152;4:75743-8672411;4:778745-819917;4:78471-3364946;4:8271481-8308825;4:85041-1921232;4:85041-2010262;4:85041-4407509;4:85041-7065426;4:85041-7845343;4:8613755-8873340;4:8868774-8873565;4:980776-981040;4:980776-981747;4:990308-992083;4:990309-992082;4:993498-998345;4:994391-998355;4:996510-998192;4:996511-998191;4:996511-998355 dbVar:nssv15165478;dbVar:nssv15148693;dbVar:nssv15149137;dbVar:nssv15125120;dbVar:nssv15134956;dbVar:nssv15136789;dbVar:nssv15148117;dbVar:nssv15165480;dbVar:nssv15164282;dbVar:nssv15164281;dbVar:nssv16215300;dbVar:nssv15145847;dbVar:nssv15132087;dbVar:nssv15132302;dbVar:nssv16254944;dbVar:nssv16207938;dbVar:nssv18830986;dbVar:nssv15150724;dbVar:nssv15777261;dbVar:nssv15151365;nssv18326348;dbVar:nssv15150634;dbVar:nssv15142189;dbVar:nssv15149870;nssv15151360;dbVar:nssv17649922;dbVar:nssv15147407;dbVar:nssv15146379;dbVar:nssv15146614;dbVar:nssv15148043;dbVar:nssv15146983;dbVar:nssv15146984;dbVar:nssv17976755;dbVar:nssv18841857;dbVar:nssv18841859;dbVar:nssv15164312;dbVar:nssv18841858;dbVar:nssv15149115 4:11526-191028879;4:12441-190904441;4:12441-49064044;4:33575-6632513;4:36425-1583294;4:36425-4098729;4:36425-47493612;4:49451-190915650;4:49451-190963766;4:49451-46339070;4:49451-49620898;4:51414-17799819;4:51414-3776843;4:51414-8224525;4:68346-2503033;4:68346-27423424;4:68346-34512694;4:68346-3713599;4:68346-4051616;4:68346-49089361;4:68346-66440622;4:68346-8731855;4:68347-190957473;4:69672-29702595;4:72448-21024037;4:72448-33132242;4:72448-39478764;4:78471-15627196;4:85041-22451641;4:85041-38701987;4:114785-47569569;4:507006-49064194;4:507006-57939396;4:1356925-49659859;4:2906395-42965249;4:6447049-20490737 4.87;4.87;18.96;99.42;97.73;99.14;19.60;4.87;4.87;20.09;18.76;52.40;99.46;99.75;99.87;34.00;27.00;99.91;99.92;18.97;14.01;99.96;4.87;31.38;44.38;28.13;23.60;59.76;41.52;24.05;19.51;18.25;15.43;16.59;16.14;20.82 dbVar:nssv18330206;dbVar:nssv16254942;dbVar:nssv15140532;dbVar:nssv15129769;dbVar:nssv15124924;dbVar:nssv15139152;dbVar:nssv15136460;dbVar:nssv15138769;dbVar:nssv15136794;dbVar:nssv15139111;dbVar:nssv15145893;dbVar:nssv15145934;dbVar:nssv15134095;dbVar:nssv15147322;dbVar:nssv8639431;dbVar:nssv15164280;dbVar:nssv16208663;dbVar:nssv15123439;dbVar:nssv15135098;dbVar:nssv15146364;dbVar:nssv15121022;dbVar:nssv15119845;dbVar:nssv16207942;dbVar:nssv15151269;dbVar:nssv15149902;dbVar:nssv15146789;dbVar:nssv17976873;dbVar:nssv15151109;dbVar:nssv17957198;dbVar:nssv15137532;dbVar:nssv15148266;dbVar:nssv17956854;dbVar:nssv17976719;dbVar:nssv16254943;dbVar:nssv16207937;dbVar:nssv15152168;dbVar:nssv15141218;dbVar:nssv16254952;dbVar:nssv15150277;dbVar:nssv17976824;dbVar:nssv16254953;dbVar:nssv15139308;dbVar:nssv16207941;dbVar:nssv15138820;nssv16207940;dbVar:nssv16207939;dbVar:nssv18330137;dbVar:nssv18330792;dbVar:nssv17649921;dbVar:nssv15150501;dbVar:nssv15146961;dbVar:nssv15146716;dbVar:nssv15147405;dbVar:nssv15146665;dbVar:nssv15146669;dbVar:nssv15146272;dbVar:nssv15146661;dbVar:nssv15146276;dbVar:nssv15774427;dbVar:nssv15151369;dbVar:nssv15145981;dbVar:nssv16207944 4:2-12785001;4:2-1328868;4:29215-1925508;4:33575-2356516;4:33575-4534781;4:36425-1957819;4:36425-3267258;4:36425-3883057;4:36425-3975771;4:36425-7361544;4:36425-9371067;4:37337-15870679;4:37337-3776839;4:37337-9370984;4:44021-19796182;4:49451-2010397;4:49451-24280482;4:49451-8872474;4:51414-1399150;4:56773-14501384;4:56773-2214932;4:56773-3872380;4:68346-10312798;4:68346-10336032;4:68346-13770107;4:68346-14614077;4:68346-1512353;4:68346-15973383;4:68346-1675143;4:68346-1999185;4:68346-20387231;4:68346-20587167;4:68346-20964575;4:68346-2137211;4:68346-2786584;4:68346-3891984;4:68346-4044985;4:68346-5046326;4:68346-5319773;4:68346-5579467;4:68346-5831521;4:68346-6056753;4:68346-6984507;4:68346-8731855;4:68346-9768141;4:68347-12369983;4:68347-2437290;4:68599-18912995;4:71553-15302739;4:71553-29006745;4:72448-10252290;4:72448-12900236;4:72448-15659658;4:72448-17279636;4:72448-28067931;4:78471-10337237;4:85041-17488365;4:3374196-13468480;4:4165335-33324781;4:4428131-17462172;4:5914110-17264668 72.74;94.62;97.77;98.37;99.16;98.17;98.91;99.09;99.11;99.52;99.62;58.73;99.09;99.63;47.08;98.87;38.38;99.75;98.51;64.38;99.32;99.61;90.78;90.57;67.87;63.93;99.78;58.47;99.80;99.83;45.77;45.32;44.50;99.84;99.88;99.92;99.92;99.94;99.94;99.94;99.94;99.95;99.95;99.96;95.87;75.60;99.86;49.35;61.06;32.14;91.34;72.49;59.66;54.04;33.21;90.58;53.36;59.41;17.85;37.92;30.46 809 4p_partial_monosomy_syndrome;Abnormality_of_mucopolysaccharide_metabolism;Abnormality_of_the_cervical_spine;Abnormality_of_the_diaphragm;Abnormality_of_the_musculature;Abnormality_of_the_nervous_system;Abnormality_of_the_vertebral_column;Acanthosis_nigricans;Achondroplasia;Arachnodactyly;Autosomal_dominant_nonsyndromic_hearing_loss_6;Autosomal_recessive_retinitis_pigmentosa;Bell-shaped_thorax;Bowed_humerus;Camptodactyly-tall_stature-scoliosis-hearing_loss_syndrome;Carcinoma;Carcinoma_of_colon;Cataract_41;Cerebellar_vermis_hypoplasia;Cervical_cancer;Cleft_palate;Colorectal_cancer;Cone-rod_dystrophy;Congenital_Stationary_Night_Blindness,_Dominant;Congenital_laryngomalacia;Congenital_myasthenic_syndrome;Congenital_myasthenic_syndrome_10;Congenital_stationary_night_blindness_autosomal_dominant_2;Connective_tissue_disorder;Coronal_craniosynostosis;Craniosynostosis_syndrome;Crouzon_syndrome;Crouzon_syndrome-acanthosis_nigricans_syndrome;Curry-Hall_syndrome;DOK7-related_condition;Dandy-Walker_syndrome;Developmental_and_epileptic_encephalopathy,_63;Diabetes_mellitus;Diaphragmatic_eventration;Disproportionate_short-limb_short_stature;Duane_retraction_syndrome;EVC-related_condition;EVC2-related_condition;Ellis-van_Creveld_syndrome;Emm-null_phenotype;Epidermal_nevus;FGFR3-Related_Disorders;FGFR3-related_chondrodysplasia;FGFR3-related_condition;FGFR3-related_disorder;Facial_asymmetry;Feeding_difficulties;Femoral_bowing;Fetal_akinesia_deformation_sequence_1;Fetal_akinesia_deformation_sequence_3;Fibrous_dysplasia_of_jaw;Generalized_non-motor_(absence)_seizure;Germ_cell_tumor_of_testis;Global_developmental_delay;Growth_delay;Hamartoma;Hurler_syndrome;Hydronephrosis;Hydroureter;Hypochondroplasia;Hypoplastic_enamel-onycholysis-hypohidrosis_syndrome;Hypotonia,_ataxia,_developmental_delay,_and_tooth_enamel_defect_syndrome;IDUA-related_condition;Inborn_genetic_diseases;Infantile_axial_hypotonia;Intellectual_disability,_autosomal_recessive_53;Interstitial_pneumonitis;Isolated_microphthalmia_6;Jeune_thoracic_dystrophy;Larsen_syndrome;Leber_congenital_amaurosis;Lethal_short-limbed_short_stature;Levy-Hollister_syndrome;Lower_limb_undergrowth;Lung_adenocarcinoma;MSX1-related_condition;Malignant_tumor_of_testis;Malignant_tumor_of_urinary_bladder;Microglossia;Micrognathia;Mucopolysaccharidosis;Mucopolysaccharidosis,_MPS-I-H/S;Mucopolysaccharidosis,_MPS-I-S;Mucopolysaccharidosis,_MPS-IV-A;Mucopolysaccharidosis_type_1;Mucopolysacchariduria;Muenke_syndrome;Multiple_myeloma;Myopia_23,_autosomal_recessive;NSD2_related_disorders;Narrow_chest;Neurodevelopmental_delay;Night_blindness;Nonsyndromic_genetic_hearing_loss;PDE6B-Related_Disorders;PDE6B-related_condition;PDE6B-related_disorder;PIGG-related_condition;Papillary_renal_cell_carcinoma,_sporadic;Rare_genetic_deafness;Rauch-Steindl_syndrome;Retinal_dystrophy;Retinitis_pigmentosa;Retinitis_pigmentosa_40;Rett_syndrome;Rod-cone_dystrophy;SEVERE_ACHONDRODYSPLASIA_WITH_DEVELOPMENTAL_DELAY_AND_ACANTHOSIS_NIGRICANS;Saethre-Chotzen_syndrome;Seborrheic_keratosis;See_cases;Seizure;Sensorineural_hearing_loss_disorder;Severe_achondroplasia-developmental_delay-acanthosis_nigricans_syndrome;Short-rib_thoracic_dysplasia_6_with_or_without_polydactyly;Short_ribs;Short_stature;Skeletal_dysplasia;Skeletal_dysplasia_with_acanthosis_nigricans;Small_for_gestational_age;Small_hand;Smith-Magenis_Syndrome-like;Spermatocytic_seminoma;Squamous_cell_carcinoma_of_the_head_and_neck;Squamous_cell_lung_carcinoma;Syndromic_intellectual_disability;Thanatophoric_dysplasia;Thanatophoric_dysplasia,_type_2;Thanatophoric_dysplasia_type_1;Transitional_cell_carcinoma_of_the_bladder;Type_2_diabetes_mellitus;Type_IV_short_rib_polydactyly_syndrome;Tyrosinase-positive_oculocutaneous_albinism;Unilateral_renal_agenesis;Upper_limb_undergrowth;Urinary_bladder_carcinoma;WFS1-Related_Spectrum_Disorders;WFS1-related_condition;WFS1-related_disorder;Wolf-Hirschhorn_like_syndrome;Wolfram-like_syndrome;Wolfram_syndrome;Wolfram_syndrome_1;not_specified chr4:21300-72378 dbVar;chr4:71970-524981 dbVar;chr4:73133-74170 dbVar;chr4:85610-147335 dbVar;chr4:103000-188000 dbVar;chr4:132436-152893 dbVar;chr4:138870-148818 dbVar;4:146750-146750 1000g;chr4:154425-188523 dbVar;chr4:155494-174423 dbVar;chr4:166964-186650 dbVar;chr4:251718-251943 dbVar;chr4:262616-285681 dbVar;chr4:271244-271302 dbVar;chr4:295501-331199 dbVar;chr4:307937-308376 dbVar;chr4:335381-378075 dbVar;4:401040-401369 1000g;4:535732-535809 gnomAD-SV_v2.1_DUP_4_10839;4:548827-549483 IMH;chr4:556315-559071 dbVar... 4:12282-121562 esv2763806;chr4:67914-130131 dbVar;chr4:72378-125835 dbVar;4:73133-74170 gnomAD-SV_v2.1_DUP_4_10814;chr4:86159-87031 dbVar;chr4:129745-155494 dbVar;chr4:138786-148918 dbVar;4:138871-148818 1000g;chr4:152769-183508 dbVar;chr4:155278-175992 dbVar;chr4:162000-167500 dbVar;chr4:191270-254556 dbVar;4:255773-255773 1000g;chr4:264283-265776 dbVar;chr4:293298-293354 dbVar;chr4:297194-398976 dbVar;chr4:308401-399950 dbVar;chr4:381471-427496 dbVar;chr4:479000-491000 dbVar;chr4:543700-551000 dbVar;chr4:556278-557708 dbVar... chr4:69000-224200 dbVar;chr4:90243-101974 dbVar;chr4:90308-102025 dbVar;4:91367-96776 1000g;chr4:114840-117344 dbVar;chr4:120580-120638 dbVar;chr4:127000-307000 dbVar;chr4:138218-138889 dbVar;chr4:141289-187522 dbVar;chr4:144992-145089 dbVar;chr4:154845-154912 dbVar;chr4:160511-164534 dbVar;chr4:194252-194740 dbVar;chr4:198780-199558 dbVar;chr4:212942-226976 dbVar;chr4:237038-239475 dbVar;chr4:244793-248873 dbVar;chr4:249822-249919 dbVar;chr4:260746-265323 dbVar;4:263958-264238 esv2665266;4:263968-264392 gnomAD-SV_v2.1_DEL_4_41495... chr4:67914-130131 dbVar;chr4:72279-204237 dbVar;4:90244-101974 1000g;chr4:91366-96776 dbVar;chr4:91373-96776 dbVar;chr4:119685-128703 dbVar;chr4:126571-135658 dbVar;chr4:128533-168126 dbVar;chr4:138870-148818 dbVar;chr4:141363-187545 dbVar;chr4:152769-183508 dbVar;4:156233-158501 nsv515005;chr4:160901-161000 dbVar;chr4:198668-199069 dbVar;4:209407-209857 DDD:12676;chr4:231372-238511 dbVar;chr4:244791-248846 dbVar;4:244794-248873 1000g;chr4:260724-264299 dbVar;chr4:260949-261120 dbVar;chr4:263968-264392 dbVar... 350019;114017;67152;46048;46518;46741;127417;127609;127611;127614;161882;283299;293074;345517;138595;44907;805614;96043;121153;129024;155921;825063;873166;106199;346122;124794;125321;125450;61253;32937;33052;42624;42918;42920;121154;51264;68579;37490;37729;37746;59962;644212;70954;71346;88010;134575;136254;137603;277083;62340;38753;... loss;gain 0.445 0.425 4:9370857-9371011 MER5B 4:9357712-9469143;4:9357889-9408758;4:9357889-9408758;4:9362634-9457876 4:9199301-9371400 High Signal Region 3 1.29231994213647 1.20702378077388 1.11611247300207 3.25348988684008 5.41905620095129 194648;616918;180072;605032;610130;252800;612041;602618;614632;134934;604407;602952;610647;602104;102680;613004;610285;104225;104250;142983;607261;604831;606201;142992 yes yes 0 1.0000e+00 1.0000e+00 1.9 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3C (152 genes, +0.90);5F (+0.00) 5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF595 NM_001286052 2 53214 88096 16544 1709 92 yes 8 intron2-txEnd CDS-3'UTR 12103 5' 71552 88096 dbVar;esv2763806 4:12282-121562;chr4:67914-130131 0.0100 dbVar chr4:67914-130131;chr4:69000-224200 0.01 93 -2.08573739588537 -0.684191486481177 152687 6 3.0550e-01 1.7753e-05 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF718 NM_001039127 6 124382 157952 33570 1239 100 no 6 txStart-txEnd 5'UTR-3'UTR 124382 157952 dbVar chr4:71970-524981;chr4:103000-188000 0.01 dbVar chr4:69000-224200;chr4:72279-204237 0.01 255403 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF876P NR_027481 1 206388 249774 43386 0 0 no 2 txStart-txEnd UTR 206388 249774 dbVar chr4:71970-524981;chr4:191270-254556 0.01 dbVar chr4:127000-307000 0.01 642280 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF732 NM_001137608 3 264463 299263 34800 1758 100 no 4 txStart-txEnd 5'UTR-3'UTR 264463 299263 dbVar chr4:71970-524981 0.01 dbVar chr4:127000-307000 0.01 672573;700031;672574;700032;672575 loss 90.28 0.287750339613682 0.450417704041247 0.400052517453145 -1.34614550091757 -3.06736199452323 654254 7 9.8159e-02 1.3118e-09 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF141 NM_003441 4 331602 378657 47055 1425 100 no 4 txStart-txEnd 5'UTR-3'UTR 331602 378657 dbVar chr4:71970-524981;chr4:297194-398976;chr4:308401-399950 0.01 658282;726705 loss 30 89.36 -0.117374836114298 -1.63248668554434 -1.22454087327741 0.724425471954094 -0.520531332003985 polydactyly, postaxial, type A6;postaxial polydactyly type A AR Limited;Supportive 23160277;26394607[PMID]_23160277[PMID] 7700 194648 ?Polydactyly, postaxial, type A6, 615226 (3) AR AR yes 7 1.0393e-01 1.6189e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MIR571 NR_030297 1 343945 344041 96 0 0 no 1 txStart-txEnd UTR 343945 344041 dbVar chr4:71970-524981;chr4:297194-398976;chr4:308401-399950;chr4:335381-378075 0.01 dbVar chr4:325395-351492 0.01 693156 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ABCA11P NR_002451 2 419223 467998 48775 0 0 no 3 txStart-txEnd UTR 419223 467998 dbVar chr4:71970-524981 0.01 51226 loss 79963 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZNF721 NM_133474 4 433776 492945 59169 2772 100 no 3 txStart-txEnd 5'UTR-3'UTR 433776 492945 dbVar chr4:71970-524981 0.01 96.95 -1.7693057852588 -2.76319865584382 170960 9 9.4789e-02 5.9729e-11 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PIGG NM_001127178 3 492998 533989 40991 2952 100 no 13 txStart-txEnd 5'UTR-3'UTR 492998 533989 Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy, 616917 (3) AR;Blood group, EMM system, 619812 (3) AR dbVar:nssv17683620;dbVar:nssv17974578;dbVar:nssv17976464;dbVar:nssv17976477;dbVar:nssv18791534;dbVar:nssv18791536;dbVar:nssv18791537;dbVar:nssv18791538;morbid:PIGG 4:492999-533989;4:493969-499930;4:494166-494410;4:499508-502759;4:501175-533158;4:502599-509994;4:509743-533158;4:512203-518547;4:524206-527790 48 Emm-null_phenotype;Inborn_genetic_diseases;Intellectual_disability,_autosomal_recessive_53;PIGG-related_condition 1627399;2851446;376537;395809;772251 gain;loss 73.18 0.208571775574472 -1.00399823985698 -0.667367098831187 1.49327706340249 -0.0905757042419409 intellectual disability, autosomal recessive 53 AR Strong 26996948;28581210;28771251 54872 616918 Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy, 616917 (3) AR;[Blood group, EMM system], 619812 (3) AR AR yes 5 5.4258e-15 8.7751e-07 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM271 NM_001362796 2 567668 570084 2416 1158 83 no 1 txStart-txEnd 5'UTR-3'UTR 567668 570084 112441426 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC105374338 NR_148199 1 570956 578655 7699 0 0 no 3 txStart-txEnd UTR 570956 578655 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PDE6B NM_000283 4 619361 664571 45210 2565 100 no 22 txStart-txEnd 5'UTR-3'UTR 619361 664571 Retinitis_pigmentosa|Retinitis_pigmentosa_40 HP:0000547 CLN:801370;dbVar:nssv15161020 4:619584-619584;4:619590-619662 Night blindness, congenital stationary, AD 2, 163500 (3) AD;Retinitis pigmentosa-40, 613801 (3) AR dbVar:nssv16213572;dbVar:nssv16213637;dbVar:nssv17171376;dbVar:nssv17171923;dbVar:nssv18788927;dbVar:nssv18788928;morbid:PDE6B 4:619417-619883;4:646966-664571;4:647642-648677;4:651220-652826;4:652722-656427;4:652742-656407;4:660321-661795 71 Autosomal_recessive_retinitis_pigmentosa;Cone-rod_dystrophy;Congenital_Stationary_Night_Blindness,_Dominant;Congenital_stationary_night_blindness_autosomal_dominant_2;Leber_congenital_amaurosis;PDE6B-Related_Disorders;PDE6B-related_condition;PDE6B-related_disorder;Retinal_dystrophy;Retinitis_pigmentosa;Retinitis_pigmentosa_40;Rod-cone_dystrophy;Tyrosinase-positive_oculocutaneous_albinism dbVar chr4:613000-729000 0.01 393944;393945 loss 31.26 -1.62508422066579 -0.147567114346182 -0.732640703348332 -0.18186725937295 -0.360251650665831 congenital stationary night blindness;congenital stationary night blindness autosomal dominant 2;retinitis pigmentosa;retinitis pigmentosa 40 AD;AR Definitive;Strong;Supportive 12641462;17044014;19578023;20301590[PMID];22334370;22968130;24265693;24760071;24938718;25472526;26667666;28559085;30646425;8075643;8075643[PMID];8394174;8595886 5158 180072 Night blindness, congenital stationary, AD 2, 163500 (3) AD;Retinitis pigmentosa-40, 613801 (3) AR AD;AR yes 6 2.6155e-27 1.6257e-13 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ATP5ME NM_007100 4 666224 668065 1841 210 100 no 4 txStart-txEnd 5'UTR-3'UTR 666224 668065 dbVar chr4:613000-729000;chr4:653000-672000 0.01 521 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MYL5 NM_001395441 1 668330 675817 7487 522 100 no 9 txStart-txEnd 5'UTR-3'UTR 668330 675817 dbVar chr4:613000-729000 0.01 77.92 -2.62354415217069 -2.53125239294469 -2.47162789907313 -0.841325117744977 -1.07172517579562 4636 9 8.4023e-14 4.4299e-08 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SLC49A3 NM_001294341 2 675617 682940 7323 1683 100 no 10 txStart-txEnd 5'UTR-3'UTR 675617 682940 dbVar chr4:613000-729000 0.01 84179 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PCGF3 NM_001317836 3 699620 763877 64257 729 100 no 12 txStart-txEnd 5'UTR-3'UTR 699620 763877 825062 gain 41.81 1.08104400698142 0.21167380707342 0.50450224433182 -1.15521787576548 2.22110482517757 10336 1 9.5326e-01 9.4340e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 PCGF3-AS1 NR_171661 1 754230 775637 21407 0 0 no 3 txStart-txEnd UTR 754230 775637 100129917 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CPLX1 NM_006651 4 778744 819917 41173 405 100 no 4 txStart-txEnd 5'UTR-3'UTR 778744 819917 Developmental and epileptic encephalopathy 63, 617976 (3) AR morbid:CPLX1 4:778745-819917 1 Developmental_and_epileptic_encephalopathy,_63 dbVar chr4:754376-832076 0.01 24484 gain 57.56 0.307891021887021 -0.276081088005473 -0.0592308346427654 -0.123982055433658 0.739036799993362 developmental and epileptic encephalopathy, 63;familial infantile myoclonic epilepsy AR Strong;Supportive 11163241;26539891;28422131;28422131[PMID] 10815 605032 Developmental and epileptic encephalopathy 63, 617976 (3) AR AR yes 2 8.2499e-01 7.9579e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 GAK NM_005255 4 843064 926104 83040 3936 100 no 28 txStart-txEnd 5'UTR-3'UTR 843064 926104 304632;304633 loss 66.55 1.00920516918233 -1.32268830826731 -0.753758448502777 -1.09712093422474 -0.06853474623291 2580 1 5.1818e-03 9.7313e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM175 NM_032326 4 926247 952444 26197 1515 100 no 11 txStart-txEnd 5'UTR-3'UTR 926247 952444 1068686;772688 loss 72.33 0.68130369659025 -0.684900012122083 -0.281672783681246 -0.335178666431938 -0.288196719712539 84286 6 3.0549e-09 4.3963e-04 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 DGKQ NM_001347 4 952674 967357 14683 2829 100 no 23 txStart-txEnd 5'UTR-3'UTR 952674 967357 855622 loss 68.02 0.720690705407562 -0.962987167732907 -0.540807434627598 -0.885541042446365 0.113301977907898 1609 3 1.7603e-09 1.1940e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SLC26A1 NM_022042 4 981444 987192 5748 2106 100 no 3 txStart-txEnd 5'UTR-3'UTR 981444 987192 19 Abnormality_of_mucopolysaccharide_metabolism;Hurler_syndrome;IDUA-related_condition;Interstitial_pneumonitis;Mucopolysaccharidosis;Mucopolysaccharidosis,_MPS-I-H/S;Mucopolysaccharidosis,_MPS-I-S;Mucopolysaccharidosis_type_1 dbVar chr4:968425-1004663 0.01 74.45 0.0296456908307138 -0.811800830743971 -0.614175007315312 -0.960716353370505 -0.560975494729554 nephrolithiasis susceptibility caused by SLC26A1 AR Limited;Moderate 24250268;27210743 10861 610130 ?Hypersulfaturia, 620372 (3) AR;?Nephrolithiasis, calcium oxalate, 1, 167030 (3) AR AR yes 8 1.0564e-11 4.0130e-06 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 IDUA NM_000203 5 980831 998352 17521 1962 100 no 14 txStart-txEnd 5'UTR-3'UTR 980831 998352 Hurler_syndrome;Mucopolysaccharidosis Ih, 607014 (3) AR;Mucopolysaccharidosis Ih;s, 607015 (3) AR;Mucopolysaccharidosis Is, 607016 (3) AR;Mucopolysaccharidosis_type_1 HP:0000943 CLN:2672009;CLN:961843;dbVar:nssv16216714;dbVar:nssv18830727;morbid:IDUA 4:990308-992083;4:990309-992082;4:993498-998345;4:996510-998192;4:996511-998191 190 Abnormality_of_mucopolysaccharide_metabolism;Hurler_syndrome;IDUA-related_condition;Inborn_genetic_diseases;Interstitial_pneumonitis;Mucopolysaccharidosis;Mucopolysaccharidosis,_MPS-I-H/S;Mucopolysaccharidosis,_MPS-I-S;Mucopolysaccharidosis,_MPS-IV-A;Mucopolysaccharidosis_type_1;Mucopolysacchariduria;See_cases dbVar chr4:968425-1004663 0.01 772749 loss 30 69.73 -1.6058292542185 -1.19882139820352 -1.40825779214199 -0.0473365386141676 0.337473103766752 Hurler syndrome;Hurler-Scheie syndrome;Scheie syndrome;mucopolysaccharidosis type 1 AR Definitive;Strong;Supportive 10466419;10735634;11735025;21394825;21480867;22976768;23917744;4221470;6821579;7550232;7951228;8328452;8664897;8680403[PMID];9391892 3425 252800 Mucopolysaccharidosis Ih, 607014 (3) AR;Mucopolysaccharidosis Ih/s, 607015 (3) AR;Mucopolysaccharidosis Is, 607016 (3) AR AR yes 6 3.7599e-13 2.6418e-08 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FGFRL1 NM_001004356 3 1005413 1020686 15273 1515 100 no 7 txStart-txEnd 5'UTR-3'UTR 1005413 1020686 dbVar chr4:997718-1171806 0.01 dbVar chr4:993000-1180000 0.01 0 0 61.34 0.15762668797229 -0.095835364724166 0.0269779205648351 -1.06125182633592 -0.304110728864919 53834 3 1.1908e-02 5.8219e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 RNF212 NM_001131034 4 1065265 1107352 42087 894 100 no 10 txStart-txEnd 5'UTR-3'UTR 1065265 1107352 ?Spermatogenic failure 62, 619673 (3) AR;Recombination rate QTL 1, 612042 (3) morbid:RNF212 4:1087097-1107352 dbVar chr4:997718-1171806 0.01 dbVar chr4:993000-1180000 0.01 955619;795738;276362;1923747;2046676;2644075;3054775;1147378;2658712;263967 gain;loss 88.48 -1.10887487197032 -0.266612828851805 -0.582493556461374 0.70441463212366 -0.142173437306223 spermatogenic failure 62 AR Limited 25342176;31125047 285498 612041 ?Spermatogenic failure 62, 619673 (3) AR;Recombination rate QTL 1, 612042 (3) AR yes yes 4 1.5645e-03 1.2523e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC105374344 NR_134676 1 1107426 1126763 19337 0 0 no 3 txStart-txEnd UTR 1107426 1126763 dbVar chr4:997718-1171806 0.01 dbVar chr4:993000-1180000 0.01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMED11P NR_033768 1 1108984 1116952 7968 0 0 no 4 txStart-txEnd UTR 1108984 1116952 dbVar chr4:997718-1171806 0.01 dbVar chr4:993000-1180000 0.01 100379220 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SPON2 NM_001199021 2 1160719 1202632 41913 996 100 no 8 txStart-txEnd 5'UTR-3'UTR 1160719 1202632 41519;41520 loss 77.93 0.386184284132793 -0.507819648222944 -0.233252267365632 0.982292085246316 0.77606556285772 10417 9 2.6609e-15 1.0881e-06 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LOC100130872 NR_024569 1 1189570 1202750 13180 0 0 no 4 txStart-txEnd UTR 1189570 1202750 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CTBP1-AS NR_104331 1 1203907 1212379 8472 0 0 no 6 txStart-txEnd UTR 1203907 1212379 1 Hypotonia,_ataxia,_developmental_delay,_and_tooth_enamel_defect_syndrome;Inborn_genetic_diseases 285463 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CTBP1 NM_001377186 1 1205232 1242918 37686 1326 100 no 9 txStart-txEnd 5'UTR-3'UTR 1205232 1242918 1 Hypotonia,_ataxia,_developmental_delay,_and_tooth_enamel_defect_syndrome;Inborn_genetic_diseases 30.46 0.372261467334061 -0.687680790971782 -0.398820302991302 -0.219318263143712 4.00265992091985 hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome AD Strong 12101226;26480814;27094857;28408745;28955726;30356033;31041561;32075774;9524128 1487 602618 Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome, 617915 (3) AD AD yes 1 9.8442e-01 9.7976e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CTBP1-DT NR_033339 1 1243227 1246795 3568 0 0 no 2 txStart-txEnd UTR 1243227 1246795 dbVar chr4:1212000-1328000 0.01 92070 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MAEA NM_001017405 3 1283678 1333925 50247 1191 100 no 9 txStart-txEnd 5'UTR-3'UTR 1283678 1333925 1071688;517272 gain 7.13 0.506320833777115 -1.33825481458672 -0.894129278429717 -0.194585519191658 3.59552380294204 10296 2 2.2741e-01 8.4486e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 UVSSA NM_001317934 2 1340995 1381837 40842 2130 100 no 14 txStart-txEnd 5'UTR-3'UTR 1340995 1381837 UV-sensitive syndrome 3, 614640 (3) AR morbid:UVSSA 4:1340996-1381837 1 771150 loss 30 81.41 -1.108132588085 -3.07621828146639 UV-sensitive syndrome;UV-sensitive syndrome 3 AR Definitive;Strong;Supportive 22466610;22466610[PMID]_22466611[PMID]_22466612[PMID] 57654 614632 UV-sensitive syndrome 3, 614640 (3) AR AR yes 7 5.4127e-25 8.8875e-14 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NKX1-1 NM_001290079 1 1396719 1400230 3511 1347 100 no 2 txStart-txEnd 5'UTR-3'UTR 1396719 1400230 dbVar chr4:1395250-1402000 0.01 80.2 2.60422559153241 2.66896012411798 54729 3 7.1465e-01 1.8842e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FAM53A NM_001174070 3 1641613 1686040 44427 1197 100 no 5 txStart-txEnd 5'UTR-3'UTR 1641613 1686040 336174;336489 loss 86.49 -0.576730190868019 -0.56780381579822 152877 6 3.5705e-03 3.0070e-05 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SLBP NM_006527 4 1694457 1714046 19589 813 100 no 8 txStart-txEnd 5'UTR-3'UTR 1694457 1714046 dbVar chr4:1663278-1724970 0.01 41.08 -0.996144409589105 -0.44060461568473 -0.660904930034766 -0.443208130978936 0.50373477013136 7884 4 6.8148e-02 5.1566e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM129 NM_001127266 2 1717678 1723050 5372 1089 100 no 4 txStart-txEnd 5'UTR-3'UTR 1717678 1723050 dbVar chr4:1663278-1724970 0.01 60.14 1.8774465029651 0.292414150336672 92305 8 2.3074e-11 1.5746e-06 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TACC3 NM_006342 3 1723247 1746898 23651 2517 100 no 16 txStart-txEnd 5'UTR-3'UTR 1723247 1746898 595624 gain 92.5 -0.738565549612952 -1.04002887445022 -0.98783763752124 -1.00228696058413 -1.35276544118498 10460 3 2.7082e-07 9.1952e-02 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FGFR3 NM_001163213 2 1795019 1810594 15575 2427 100 no 18 txStart-txEnd 5'UTR-3'UTR 1795019 1810594 Achondroplasia, 100800 (3) AD;Bladder cancer, somatic, 109800 (3);CATSHL syndrome, 610474 (3) AR,AD;Cervical cancer, somatic, 603956 (3);Colorectal cancer, somatic, 114500 (3);Crouzon syndrome with acanthosis nigricans, 612247 (3) AD;Hypochondroplasia, 146000 (3) AD;LADD syndrome 2, 620192 (3) AD;Muenke syndrome, 602849 (3) AD;Nevus, epidermal, somatic, 162900 (3);SADDAN, 616482 (3) AD;Spermatocytic seminoma, somatic, 273300 (3);Thanatophoric dysplasia, type I, 187600 (3) AD;Thanatophoric dysplasia, type II, 187601 (3) AD morbid:FGFR3 4:1795020-1810594 36 Abnormality_of_the_nervous_system;Acanthosis_nigricans;Achondroplasia;Bell-shaped_thorax;Bowed_humerus;Camptodactyly-tall_stature-scoliosis-hearing_loss_syndrome;Carcinoma;Carcinoma_of_colon;Cervical_cancer;Colorectal_cancer;Connective_tissue_disorder;Coronal_craniosynostosis;Craniosynostosis_syndrome;Crouzon_syndrome;Crouzon_syndrome-acanthosis_nigricans_syndrome;Disproportionate_short-limb_short_stature;Epidermal_nevus;FGFR3-Related_Disorders;FGFR3-related_chondrodysplasia;FGFR3-related_condition;FGFR3-related_disorder;Facial_asymmetry;Femoral_bowing;Generalized_non-motor_(absence)_seizure;Germ_cell_tumor_of_testis;Growth_delay;Hamartoma;Hypochondroplasia;Inborn_genetic_diseases;Infantile_axial_hypotonia;Larsen_syndrome;Lethal_short-limbed_short_stature;Levy-Hollister_syndrome;Lower_limb_undergrowth;Lung_adenocarcinoma;Malignant_tumor_of_testis;Malignant_tumor_of_urinary_bladder;Muenke_syndrome;Multiple_myeloma;Narrow_chest;Neurodevelopmental_delay;Papillary_renal_cell_carcinoma,_sporadic;SEVERE_ACHONDRODYSPLASIA_WITH_DEVELOPMENTAL_DELAY_AND_ACANTHOSIS_NIGRICANS;Saethre-Chotzen_syndrome;Seborrheic_keratosis;See_cases;Seizure;Severe_achondroplasia-developmental_delay-acanthosis_nigricans_syndrome;Short_ribs;Short_stature;Skeletal_dysplasia;Skeletal_dysplasia_with_acanthosis_nigricans;Small_for_gestational_age;Spermatocytic_seminoma;Squamous_cell_carcinoma_of_the_head_and_neck;Squamous_cell_lung_carcinoma;Thanatophoric_dysplasia;Thanatophoric_dysplasia,_type_2;Thanatophoric_dysplasia_type_1;Transitional_cell_carcinoma_of_the_bladder;Unilateral_renal_agenesis;Upper_limb_undergrowth;Urinary_bladder_carcinoma;not_specified 393816;393817;395197 loss 0 0 6.4 -0.683349552436101 -0.392116289350703 -0.538573860699497 -2.22163439002498 1.36559781959522 Achondroplasia;Crouzon syndrome-acanthosis nigricans syndrome;LADD syndrome;LADD syndrome 1;Muenke syndrome;camptodactyly-tall stature-scoliosis-hearing loss syndrome;hypochondroplasia;isolated brachycephaly;isolated plagiocephaly;severe achondroplasia-developmental delay-acanthosis nigricans syndrome;thanatophoric dysplasia type 1;thanatophoric dysplasia type 2 AD;AR;sD Definitive;Limited;Moderate;Strong;Supportive 10053006;10053006[PMID]_18076102[PMID];10215410;10671061;10696568;10914960[PMID];11055896;11406607;11467490;15909185;16411219;16441300;16501574;16501574[PMID];16912704;17033969;17033969[PMID]_24864036[PMID];18076102;18818193;194190;19449430;20301540[PMID];20301588[PMID]_20301628[PMID]_21438135[PMID];20301628[PMID];20301650[PMID]_23149434[PMID];21536014;23149434[PMID];24864036;27139183;28249712;28483234;7493034;7647778;7670477;7758520;7773297;7847369;7913883;8078586;8589686;8630492;8640234;8845844;8880573;8880574;9042914;9279753;9300656;9450868;9452043;9580776 2261 134934 Achondroplasia, 100800 (3) AD;Bladder cancer, somatic, 109800 (3);CATSHL syndrome, 610474 (3) AR,AD;Cervical cancer, somatic, 603956 (3);Colorectal cancer, somatic, 114500 (3);Crouzon syndrome with acanthosis nigricans, 612247 (3) AD;Hypochondroplasia, 146000 (3) AD;LADD syndrome 2, 620192 (3) AD;Muenke syndrome, 602849 (3) AD;Nevus, epidermal, somatic, 162900 (3);SADDAN, 616482 (3) AD;Spermatocytic seminoma, somatic, 273300 (3);Thanatophoric dysplasia, type I, 187600 (3) AD;Thanatophoric dysplasia, type II, 187601 (3) AD AD;AR,AD yes 3 1.6432e-05 2.9091e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LETM1 NM_012318 3 1813205 1857883 44678 2220 100 no 14 txStart-txEnd 5'UTR-3'UTR 1813205 1857883 Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction, 620089 (3) AR morbid:LETM1 4:1813206-1857883 0 0 63.78 0.214548231055587 -0.175454101774909 -0.0279109913872425 -1.46983950545222 1.90036967420169 neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction AR Moderate;Strong 26960370;27287194;30378700;30773800;36055214 3954 604407 Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction, 620089 (3) AR AR yes 3 1.2141e-06 8.1055e-02 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NSD2 NM_001042424 3 1873119 1983919 110800 4098 100 no 22 txStart-txEnd 5'UTR-3'UTR 1873119 1983919 Rauch-Steindl syndrome, 619695 (3) AD morbid:NSD2 4:1902353-1950545 27 4p_partial_monosomy_syndrome;Global_developmental_delay;Inborn_genetic_diseases;NSD2_related_disorders;Neurodevelopmental_delay;Rauch-Steindl_syndrome;Syndromic_intellectual_disability;Wolf-Hirschhorn_like_syndrome 621015;393850;393851;395144;395188;264093;743764;743765;743766;743767 loss;gain 3 0 Rauch-Steindl syndrome;Wolf-Hirschhorn syndrome;syndromic intellectual disability AD Definitive;Limited;Strong 19483677;26633542;28600779;29760529;29892088;30244530;30345613;31171569;9618163 7468 602952 Rauch-Steindl syndrome, 619695 (3) AD AD yes full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SCARNA22 NR_003004 1 1976362 1976487 125 0 0 no 1 txStart-txEnd UTR 1976362 1976487 677770 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NELFA NM_005663 5 1984449 2010701 26252 1587 100 no 11 txStart-txEnd 5'UTR-3'UTR 1984449 2010701 430475 gain 0 0 62.86 0.0789021097033232 0.586448065563417 0.486612084123194 -0.704500724266535 2.35326609523799 7469 2 1.3469e-01 1.6689e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MIR943 NR_030641 1 1988110 1988204 94 0 0 no 1 txStart-txEnd UTR 1988110 1988204 100126332 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 C4orf48 NM_001141936 3 2043721 2045691 1970 288 100 no 4 txStart-txEnd 5'UTR-3'UTR 2043721 2045691 80.21 401115 7 5.1423e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NAT8L NM_178557 4 2061053 2070816 9763 909 100 no 3 txStart-txEnd 5'UTR-3'UTR 2061053 2070816 30 0 40.87 0.098456637925367 0.547035422647778 0.555421231184509 -0.17378562567541 2.72200675038499 N-acetylaspartate deficiency AR Limited 11310630;15328569;16802720;19807691;26511242 339983 610647 ?N-acetylaspartate deficiency, 614063 (3) AR AR yes 2 8.6458e-01 3.2468e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 POLN NM_181808 4 2073644 2243848 170204 2703 100 no 26 txStart-txEnd 5'UTR-3'UTR 2073644 2243848 264094;276854;502048;709331;517288;1750572;595645;276858;264095 gain;loss 74.11 1.28008098953073 -0.213680271829885 0.298427608261686 0.0230368692484615 -1.08931776314455 353497 7 9.4880e-41 2.9966e-32 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HAUS3 NM_001303143 2 2230075 2243848 13773 1812 100 no 6 txStart-txEnd 5'UTR-3'UTR 2230075 2243848 46.58 0.701548607121356 -0.365908352795815 0.0332648069020548 -0.527208917402428 -2.11601983727089 79441 6 1.2992e-09 8.8992e-07 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MXD4 NM_006454 3 2249158 2263836 14678 630 100 no 6 txStart-txEnd 5'UTR-3'UTR 2249158 2263836 dbVar chr4:2235501-2406763;chr4:2237000-2302000 0.01 51.38 0.152551047660427 -0.352633837012323 -0.186392860565083 -0.362920265024982 1.29214097300775 10608 2 7.7635e-01 8.9694e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MIR4800 NR_039964 1 2251803 2251883 80 0 0 no 1 txStart-txEnd UTR 2251803 2251883 dbVar chr4:2235501-2406763;chr4:2237000-2302000 0.01 100616358 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZFYVE28 NM_020972 3 2271323 2420372 149049 2664 100 no 13 txStart-txEnd 5'UTR-3'UTR 2271323 2420372 2994794;771752;771755;777955;595646;596492;596551;771756;771757;1004782;821947;807953;595647;191262;379298;379650;307267;795798;821948;304613;305190;400287;2444715;1767057;771775;771778;324444;771781;550613;814241;552440;771785 gain;loss 65.21 -0.00272190900027315 -0.788064481059993 -0.590406277851698 -0.457051628812482 -0.248524904723244 57732 2 7.2340e-02 8.8846e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 CFAP99 NM_001193282 4 2420681 2464729 44048 1941 100 no 16 txStart-txEnd 5'UTR-3'UTR 2420681 2464729 598292;24429;552442;1010128;1012924;16682;359729;5118;216085;364891 gain;loss 402160 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 RNF4 NM_002938 5 2470832 2517584 46752 573 100 no 8 txStart-txEnd 5'UTR-3'UTR 2470832 2517584 329644 gain 46.49 0.675314441657105 -0.278968200252929 0.0738937137831485 0.142993789011855 1.01071894719792 6047 2 7.9973e-01 6.2895e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FAM193A NM_001366318 2 2538373 2734300 195927 4548 100 no 21 txStart-txEnd 5'UTR-3'UTR 2538373 2734300 1010130;368037;338961;343190;343797;343815;414144;1079445;1144241;771821;771822;771825;771826;1034912 gain;loss 63.75 0.047435784931723 0.578303279433319 0.446297134803958 -0.738211104213101 1.24551033534962 8603 0 9.9993e-01 9.9782e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TNIP2 NM_024309 4 2743374 2758063 14689 1290 100 no 6 txStart-txEnd 5'UTR-3'UTR 2743374 2758063 81.36 0.00376891322505335 0.175301121417126 0.165045961017247 0.837642525932054 1.18082169671465 79155 3 1.5926e-03 2.9733e-06 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 SH3BP2 NM_001145856 2 2819896 2842823 22927 1857 100 no 13 txStart-txEnd 5'UTR-3'UTR 2819896 2842823 Cherubism, 118400 (3) AD morbid:SH3BP2 4:2820541-2842823 7 Fibrous_dysplasia_of_jaw 399644;399775;399782;399789;21987;379301;7989;1004787;415279 gain;loss 63.94 0.0147924168443993 -0.755069155443864 -0.557230884715189 -0.774788091773142 0.0928341710725898 cherubism AD Limited;Strong;Supportive 11381256;12900899;17147794;17321449;17368082;19038533;22153076;22153077;22640988;24382142;24916406;26064398;NULL 6452 602104 Cherubism, 118400 (3) AD AD yes 6 1.1560e-11 3.1019e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ADD1 NM_001354761 2 2845570 2931789 86219 2400 100 no 16 txStart-txEnd 5'UTR-3'UTR 2845570 2931789 IMH 4:2823210-17706072 0.0144 470841;418829;419175;276889 loss;gain 46.84 0.415100440885564 -0.0353582367682211 0.160620922610348 1.55687904782076 0.599493733703596 118 102680 (Hypertension, essential, salt-sensitive), 145500 (3) Multifactorial Multifactorial yes 1 9.8830e-01 6.1130e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MFSD10 NM_001146069 2 2932293 2936552 4259 1368 100 no 13 txStart-txEnd 5'UTR-3'UTR 2932293 2936552 IMH 4:2823210-17706072 0.0144 74.85 0.411355639726539 0.128499204561582 0.297239579860913 -3.22135273058939 -2.0505953640051 10227 7 7.3331e-11 3.0178e-07 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NOP14-AS1 NR_015453 2 2937272 2952805 15533 0 0 no 4 txStart-txEnd UTR 2937272 2952805 IMH 4:2823210-17706072 0.0144 317648 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NOP14 NM_001291978 2 2939662 2965133 25471 2574 100 no 18 txStart-txEnd 5'UTR-3'UTR 2939662 2965133 IMH 4:2823210-17706072 0.0144 76.1 -0.287444310372334 -1.08649031284551 8602 2 2.1363e-06 1.7449e-02 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 GRK4 NM_182982 3 2965297 3042487 77190 1737 100 no 16 txStart-txEnd 5'UTR-3'UTR 2965297 3042487 IMH 4:2823210-17706072 0.0144 771860;1792169;2744065;998224;998290;998291;946197;946225;2543710 loss;gain 77.79 -1.99297870008351 -1.29609278714656 -1.46605851541056 -0.226834639209249 -0.865456519909477 2868 6 1.6286e-15 5.6904e-07 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HTT-AS NR_045414 1 3064972 3076241 11269 0 0 no 3 txStart-txEnd UTR 3064972 3076241 IMH 4:2823210-17706072 0.0144 100750326 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HTT NM_002111 8 3076407 3245687 169280 9429 100 no 67 txStart-txEnd 5'UTR-3'UTR 3076407 3245687 Huntington disease, 143100 (3) AD;Lopes-Maciel-Rodan syndrome, 617435 (3) AR morbid:HTT 4:3076408-3245687 3 IMH 4:2823210-17706072 0.0144 771871;752640;771875;454017;743796;743797;743798;900268;771876;414150;2246285;1004794;557895;298835 gain;loss 7.59 -0.672019089975884 1.20702378077388 0.455761090475751 -0.292338464564844 2.75557960790302 Huntington disease;Lopes-Maciel-Rodan syndrome;juvenile Huntington disease AD;AR Definitive;Limited;Strong;Supportive 11264541;17181545[PMID];20301482[PMID]_21566141[PMID];248284;26740508;27329733;7550343;7618107;7774020;8401587;8458085 3064 613004 Huntington disease, 143100 (3) AD;Lopes-Maciel-Rodan syndrome, 617435 (3) AR AD;AR yes yes 0 1.0000e+00 1.0000e+00 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 MSANTD1 NM_001042690 2 3250885 3258340 7455 837 100 no 3 txStart-txEnd 5'UTR-3'UTR 3250885 3258340 IMH 4:2823210-17706072 0.0144 771893 loss 38.82 0.0606051954062481 0.881143579184346 345222 2 8.0456e-01 3.2217e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 RGS12 NM_001394155 1 3287617 3441640 154023 4344 100 no 18 txStart-txEnd 5'UTR-3'UTR 3287617 3441640 IMH 4:2823210-17706072 0.0144 383092;383314;823588;264108;1431112;1891532;163919;771917;771918;807960;383093;771931;771932;487963;837508;276898;964780;337104;337381;337392;771933;4164 loss;gain 76.68 0.764664139864726 0.714317785060336 0.923141277111761 -0.25533666429365 0.674471945471649 6002 3 4.0922e-09 5.6037e-04 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 HGFAC NM_001297439 2 3443694 3451213 7519 1989 100 no 15 txStart-txEnd 5'UTR-3'UTR 3443694 3451213 IMH 4:2823210-17706072 0.0144 11233;363961;379302;598304;601309;337939;346109;135533 gain;loss 76.94 -2.62354415217069 0.291115018050139 -2.47162789907313 -2.1421417021426 -1.44878648893363 3083 4 1.9843e-08 5.2082e-07 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 DOK7 NM_001301071 2 3465032 3503209 38177 1827 100 no 10 txStart-txEnd 5'UTR-3'UTR 3465032 3503209 Fetal akinesia deformation sequence 3, 618389 (3) AR;Myasthenic syndrome, congenital, 10, 254300 (3) AR dbVar:nssv15130945;dbVar:nssv15131476;dbVar:nssv15770186;dbVar:nssv16213451;dbVar:nssv16214333;dbVar:nssv17971686;dbVar:nssv17972166;dbVar:nssv17976550;dbVar:nssv18786333;dbVar:nssv18790180;morbid:DOK7 4:3465094-3495238;4:3465104-3465298;4:3475114-3491543;4:3478271-3491403;4:3486271-3496209;4:3487104-3487370;4:3487247-3495248;4:3487257-3487395;4:3487257-3495238;4:3494467-3495228;4:3495083-3495158 44 Abnormality_of_the_musculature;Congenital_myasthenic_syndrome;Congenital_myasthenic_syndrome_10;DOK7-related_condition;Fetal_akinesia_deformation_sequence_1;Fetal_akinesia_deformation_sequence_3;Inborn_genetic_diseases;Rett_syndrome;See_cases IMH 4:2823210-17706072 0.0144 1033209;380623;380690;380693;380694;1033210;1064617;1008804;344702;344987;358558;358710;368870;383792;384043;332618;4167;32348;32581;537618;26112;393878;393879;21990;135534;136245;134562;21991 loss;gain 30 75.35 -2.68253992069213 -3.72411383897722 congenital myasthenic syndrome 10;fetal akinesia deformation sequence 1;fetal akinesia deformation sequence 3;postsynaptic congenital myasthenic syndrome AR Definitive;Limited;Strong;Supportive 16794080;16917026;17439981;18626973;19261599;19261599[PMID];20147321;20301347[PMID];29395672;31453852;32360404 285489 610285 Fetal akinesia deformation sequence 3, 618389 (3) AR;Myasthenic syndrome, congenital, 10, 254300 (3) AR AR yes 5 1.0263e-04 4.8084e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LRPAP1 NM_002337 4 3505338 3534149 28811 1074 100 no 8 txStart-txEnd 5'UTR-3'UTR 3505338 3534149 Myopia 23, AR, 615431 (3) AR morbid:LRPAP1 4:3505339-3534149 1 Myopia_23,_autosomal_recessive IMH 4:2823210-17706072 0.0144 393882;393883 loss 30 81.97 -0.901439467568047 -1.0008332959639 -1.03424805406881 -0.233147203181143 -1.38131789177637 myopia 23, autosomal recessive AR Limited;Strong 23830514;25525168 4043 104225 Myopia 23, AR, 615431 (3) AR AR yes 6 4.4951e-07 6.0843e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LINC00955 NR_040045 1 3578595 3592712 14117 0 0 no 3 txStart-txEnd UTR 3578595 3592712 IMH 4:2823210-17706072 0.0144 1024419;703590;677165;649536;654469;651650;675129 gain;loss 93.6 285492 8 4.5772e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LINC02171 NR_034136 1 3675319 3679582 4263 0 0 no 3 txStart-txEnd UTR 3675319 3679582 dbVar chr4:3599563-3715752;chr4:3601813-3701023;chr4:3621281-3742478 0.01 IMH 4:2823210-17706072 0.0144 100133461 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ADRA2C NM_000683 4 3768111 3770253 2142 1389 72 no 1 txStart-txEnd 5'UTR-3'UTR 3768111 3770253 IMH 4:2823210-17706072 0.0144 68.35 3.21047317301589 5.41905620095129 152 104250 (Congestive heart failure and beta-blocker response, modifier of) (3) yes 3 5.0159e-01 6.4595e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 FAM86EP NR_130740 1 3943486 3957155 13669 0 0 no 4 txStart-txEnd UTR 3943486 3957155 dbVar chr4:3895471-4250523;chr4:3898327-4166047;chr4:3906095-3993252;chr4:3938384-4025767;chr4:3939497-4298000 0.01 dbVar chr4:3894913-4168551;chr4:3897463-4171386;chr4:3906095-3993252;chr4:3923039-4103069 0.01 IMH 4:2823210-17706072 0.0144 348926 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 OTOP1 NM_177998 3 4190452 4228656 38204 1839 100 no 6 txStart-txEnd 5'UTR-3'UTR 4190452 4228656 dbVar chr4:3895471-4250523;chr4:3939497-4298000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 2487622;1690047;772056;697250;726723 gain;loss 80.7 0.337011959699387 0.333342940376347 0.48201697995522 0.532976598896309 -0.342636515952079 133060 9 4.8437e-24 7.3147e-16 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 TMEM128 NM_001297551 2 4237268 4249950 12682 498 100 no 5 txStart-txEnd 5'UTR-3'UTR 4237268 4249950 dbVar chr4:3895471-4250523;chr4:3939497-4298000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 73.9 0.701580942281967 -0.111669494459405 85013 8 1.9994e-04 1.1006e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 LYAR NM_017816 3 4269427 4291881 22454 1140 100 no 10 txStart-txEnd 5'UTR-3'UTR 4269427 4291881 dbVar chr4:3939497-4298000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 65.63 -1.04982790537607 0.837810587333259 0.0401032398207032 0.075048187998812 -0.816993645198656 55646 5 3.7580e-07 1.3245e-04 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 ZBTB49 NM_001330625 2 4291977 4323510 31533 2298 100 no 8 txStart-txEnd 5'UTR-3'UTR 4291977 4323510 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 89.21 -0.48130989574319 0.452744382601107 0.130333981724112 -0.597063638061633 0.18239534186363 166793 4 1.3752e-08 9.1642e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 NSG1 NM_001382227 1 4388828 4420785 31957 585 100 no 6 txStart-txEnd 5'UTR-3'UTR 4388828 4420785 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 547721 loss -0.025549754331335 0.153242929586267 0.138678963648336 0.898629456776545 -0.214997258794035 27065 7 8.8286e-03 4.5383e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2-p16.3 STX18 NM_016930 4 4420694 4543775 123081 1008 100 no 11 txStart-txEnd 5'UTR-3'UTR 4420694 4543775 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 563850;772099;772100;709371;709372;563851;65871;80739;80956;80957;81927;82978;86653;557915;54942;76939;38745;53278;106193;106358;72950;73046;73051;70947;93080;2794725;1217715;1310939;2065540;2262085;3111299 loss;gain 39.55 0.843231894587517 0.108678775214296 0.455109011286475 -0.165997903989801 0.517811238015827 53407 5 2.4881e-07 1.1678e-06 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.3 STX18-IT1 NR_126434 1 4477847 4483427 5580 0 0 no 4 txStart-txEnd UTR 4477847 4483427 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 104472519 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 STX18-AS1 NR_037888 1 4543857 4712665 168808 0 0 no 6 txStart-txEnd UTR 4543857 4712665 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 100507266 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 SNORD162 NR_145783 1 4666052 4666150 98 0 0 no 1 txStart-txEnd UTR 4666052 4666150 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 109623454 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LOC101928279 NR_125892 1 4763486 4789101 25615 0 0 no 3 txStart-txEnd UTR 4763486 4789101 dbVar chr4:4763025-4828041 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LINC01396 NR_125765 1 4846163 4852554 6391 0 0 no 4 txStart-txEnd UTR 4846163 4852554 dbVar chr4:4785101-5227993;chr4:4833228-4894750 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 103695434 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 MSX1 NM_002448 3 4861391 4865663 4272 912 100 no 2 txStart-txEnd 5'UTR-3'UTR 4861391 4865663 Ectodermal dysplasia 3, Witkop type, 189500 (3) AD;Orofacial cleft 5, 608874 (3) AD;Tooth agenesis, selective, 1, with or without orofacial cleft, 106600 (3) AD HI3:MSX1;morbid:MSX1 4:4861392-4865663;4:4861393-4865663 6 Hypoplastic_enamel-onycholysis-hypohidrosis_syndrome;MSX1-related_condition dbVar chr4:4785101-5227993;chr4:4833228-4894750 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 3 0 1.21 0.15460042661567 0.172845644735031 0.256065903692486 1.56448356794936 2.50372489686823 orofacial cleft 5;tooth agenesis;tooth agenesis, selective, 1;tooth and nail syndrome AD Definitive;Limited;Strong;Supportive 1054139;10742093;10815578;11369996;11369996[PMID];12097313;12807959;15264286;15354328;16498076;26502894;4521949;8466837;8469557;8696335;9742121;NULL 4487 142983 Ectodermal dysplasia 3, Witkop type, 189500 (3) AD;Orofacial cleft 5, 608874 (3) AD;Tooth agenesis, selective, 1, with or without orofacial cleft, 106600 (3) AD AD yes 5 1.6517e-01 2.7536e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LOC101928306 NR_125893 1 4922534 4990398 67864 0 0 no 3 txStart-txEnd UTR 4922534 4990398 dbVar chr4:4785101-5227993 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 CYTL1 NM_018659 3 5016312 5021185 4873 411 100 no 4 txStart-txEnd 5'UTR-3'UTR 5016312 5021185 dbVar chr4:4785101-5227993 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 76.44 -0.6295570831736 0.0670299843738293 -0.200045256499347 0.45277691276168 0.0974901129923348 54360 9 1.0733e-05 6.5277e-04 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 STK32B NM_018401 3 5053206 5502716 449510 1245 100 no 12 txStart-txEnd 5'UTR-3'UTR 5053206 5502716 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 276969;1142068;840293;150666;582526;839300;59951;557921;544016;544289;544324;1074112;1057831;1070055;1060917;1069420;1070266;1072175;785823;948123;939218;957498;802673;810101;276970;2585054;415313;414186;415314;414187;378165;167036;844336;2974848;839301;1304163;1052805;322688;327704;11244;10184;229010;230359;9976;22826;21997;24454;3103240;853410;11245;24455;... gain;loss 39.31 -0.246593908057665 0.0285262483698947 -0.063872653370671 -2.65953872619111 -2.04902349969142 55351 5 4.9116e-08 4.3235e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 LINC01587 NR_126519 1 5526295 5529528 3233 0 0 no 4 txStart-txEnd UTR 5526295 5529528 dbVar chr4:5486512-5554541 0.01 dbVar chr4:5334999-5780000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 96.4 10141 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 EVC2 NM_147127 5 5564165 5710286 146121 3927 100 no 22 txStart-txEnd 5'UTR-3'UTR 5564165 5710286 dbVar:nssv17973849 4:5567009-5587839 dbVar:nssv15770321;dbVar:nssv16213046;dbVar:nssv16213271;dbVar:nssv16297119;dbVar:nssv17172955;dbVar:nssv17971266;dbVar:nssv17971361;dbVar:nssv17972056;dbVar:nssv18790018;dbVar:nssv18790020;dbVar:nssv18790021;dbVar:nssv18790022 4:5564566-5578191;4:5564566-5586587;4:5564576-5567096;4:5570162-5570377;4:5576403-5576509;4:5630277-5633769;4:5630336-5635926;4:5630338-5635927;4:5642222-5642585;4:5690875-5691080;4:5690875-5696238;4:5696053-5696238 142 Curry-Hall_syndrome;EVC2-related_condition;Ellis-van_Creveld_syndrome;Inborn_genetic_diseases;Jeune_thoracic_dystrophy;Short-rib_thoracic_dysplasia_6_with_or_without_polydactyly;Type_IV_short_rib_polydactyly_syndrome;not_specified dbVar chr4:5334999-5780000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 230363;1064620;853422;795819;1033245;1034393;1118405;96040;674543;291667;1881710;2882000;229014;2912386;264146;414192;415320;1033246;1034400 gain;loss 30 0 74.81 -0.675336787286134 -0.144705826949755 -0.333473000003108 -1.44193705805358 -2.99791740003004 Ellis-van Creveld syndrome;acrofacial dysostosis, Weyers type AD;AR Definitive;Strong;Supportive 16404586;17024374;17547743;19810119;19876929;225500;22616035;23220543;23220543[PMID]_22791528[PMID]_12571802[PMID]_12468274[PMID];23220543[PMID]_22791528[PMID]_16404586[PMID] 132884 607261 Ellis-van Creveld syndrome, 225500 (3) AR;Weyers acrofacial dysostosis, 193530 (3) AD AD;AR yes 5 1.0207e-34 1.0533e-21 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 EVC NM_153717 3 5712927 5816032 103105 2979 100 no 21 txStart-txEnd 5'UTR-3'UTR 5712927 5816032 dbVar:nssv17172169 4:5785270-5803831 ?Weyers acrofacial dysostosis, 193530 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR;Curry-Hall_syndrome|Ellis-van_Creveld_syndrome CLN:1313135;dbVar:nssv15144315;dbVar:nssv16211870;dbVar:nssv16297131;dbVar:nssv17172168;dbVar:nssv17172572;dbVar:nssv17172573;dbVar:nssv17172574;dbVar:nssv17971734;dbVar:nssv17973718;nssv17974037;dbVar:nssv17975024;dbVar:nssv18786244;dbVar:nssv18790117;dbVar:nssv18790118;dbVar:nssv18790119;dbVar:nssv18790120;morbid:EVC 4:5712928-5816032;4:5713109-5714221;4:5713159-5713318;4:5731025-5759862;4:5733143-5735172;4:5749726-5755670;4:5754554-5755670;4:5754554-5758099;4:5754554-5785501;4:5754599-5758602;4:5785270-5812774;4:5795340-5795484;4:5795341-5795483;4:5798730-5798979;4:5798740-5798969;4:5803668-5806578;4:5809919-5811348 115 Curry-Hall_syndrome;EVC-related_condition;Ellis-van_Creveld_syndrome;Short-rib_thoracic_dysplasia_6_with_or_without_polydactyly IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 853431;772308;772309;1995043;853433;592487;966873;2776114;772310;772311;772312;679097;657724;652298;684495;698699;673787;690677;690031;653456;685609;649544;649545;649546;347080 loss;gain 72.76 -2.57221447207538 -0.38737545040403 -1.26125942639438 -0.471176482163648 -1.41925515956187 Ellis-van Creveld syndrome;acrofacial dysostosis, Weyers type AD;AR Definitive;Limited;Strong;Supportive 10700184;10700184[PMID];12468274;12571802;14217223;17024374;21815252;23220543;23220543[PMID]_22791528[PMID]_19744229[PMID]_18947413[PMID];26748586;29321360;30076350;7218275;7628126 2121 604831 ?Weyers acrofacial dysostosis, 193530 (3) AD;Ellis-van Creveld syndrome, 225500 (3) AR AD;AR yes yes 5 3.4620e-25 8.0150e-08 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 CRMP1 NM_001014809 3 5822490 5894813 72323 2061 100 no 14 txStart-txEnd 5'UTR-3'UTR 5822490 5894813 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 1033254;552468;743863 loss;gain 43.19 -2.45831687825306 -0.486186941840208 -1.27538361497834 0.0326224850029478 2.34696639804313 1400 1 9.9173e-01 9.5327e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.2 MIR378D1 NR_039608 1 5925001 5925055 54 0 0 no 1 txStart-txEnd UTR 5925001 5925055 dbVar chr4:5918046-5928942 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 100616201 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1-p16.2 C4orf50 NM_001364689 2 5958836 6020273 61437 4527 100 no 12 txStart-txEnd 5'UTR-3'UTR 5958836 6020273 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 1225807;2492568;2604601;317153;2175936;2681934;2268610;2281038;2715789;986743;988074;1033260;592494;2426862;2254058;548440 gain;loss 98.01 0.369490376960693 0.371330581311454 0.517389412359409 -2.62911053265251 -1.8079483903393 389197 7 7.7361e-19 6.3423e-10 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 JAKMIP1 NM_001099433 2 6027925 6202276 174351 2496 100 no 21 txStart-txEnd 5'UTR-3'UTR 6027925 6202276 1 Smith-Magenis_Syndrome-like dbVar chr4:5960239-6587328 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 853446;778397;472833;220016;220324;220329;220345;220347;220358;393934;393935;853449;393936;393937;147065;277014;939223;1035829;1035831 loss;gain 52.99 0.975078008148592 0.865866943304307 1.11611247300207 0.172471674763915 3.32151835531883 152789 0 9.9986e-01 9.9317e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 JAKMIP1-DT NR_037863 1 6202459 6235663 33204 0 0 no 4 txStart-txEnd UTR 6202459 6235663 dbVar chr4:5960239-6587328 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 285484 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 WFS1 NM_001145853 1 6271576 6304992 33416 2673 100 no 8 txStart-txEnd 5'UTR-3'UTR 6271576 6304992 ?Cataract 41, 116400 (3) AD;Deafness, AD 6;14;38, 600965 (3) AD;Wolfram syndrome 1, 222300 (3) AR;Wolfram-like syndrome, AD, 614296 (3) AD;Diabetes mellitus, noninsulin-dependent, association with, 125853 (3) AD dbVar:nssv18790633;morbid:WFS1 4:6271577-6304992;4:6279184-6279434 114 Abnormality_of_the_cervical_spine;Abnormality_of_the_diaphragm;Abnormality_of_the_vertebral_column;Arachnodactyly;Autosomal_dominant_nonsyndromic_hearing_loss_6;Cataract_41;Cerebellar_vermis_hypoplasia;Cleft_palate;Congenital_laryngomalacia;Dandy-Walker_syndrome;Diabetes_mellitus;Diaphragmatic_eventration;Duane_retraction_syndrome;Feeding_difficulties;Global_developmental_delay;Hydronephrosis;Hydroureter;Inborn_genetic_diseases;Microglossia;Micrognathia;Night_blindness;Nonsyndromic_genetic_hearing_loss;Rare_genetic_deafness;See_cases;Sensorineural_hearing_loss_disorder;Small_hand;Type_2_diabetes_mellitus;WFS1-Related_Spectrum_Disorders;WFS1-related_condition;WFS1-related_disorder;Wolfram-like_syndrome;Wolfram_syndrome;Wolfram_syndrome_1 dbVar chr4:5960239-6587328 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 973360;107748;44904;51246;59959;67149;32350;320364 gain;loss 0 0 33.79 0.279433736423428 0.30418592454869 0.420298457025828 Wolfram syndrome;Wolfram syndrome 1;Wolfram-like syndrome;autosomal dominant nonsyndromic hearing loss;autosomal dominant nonsyndromic hearing loss 6;cataract 41;early-onset nuclear cataract;type 2 diabetes mellitus AD;AR Definitive;Limited;Strong;Supportive 10521293;11161832;11295831;11317648;11709537;11709538;12073007;12107816;12707373;12754709;12955714;14724730;15070927;15151504;15277431;15503287;15605410;16151413;16442662;16459465;16648378;16806192;16806192[PMID]_12913071[PMID];17492394;17568405;18544103;18660851;18806274;19042979;19160074;20069065;20069065[PMID]_20301750[PMID];20301607[PMID]_24148127[PMID];20875904;21067485;21446023;21538838;21564155;21602428;21623591;21726277;21823543;21968327;22226368;222300;22238590;22311385;22781099;23103830;23373429;23531866;23531866[PMID];243330;248846;251462;25250959;25390390;27395765;28802351;29529044;31313226;31555371;34014271;35018440;606201;9771706 7466 606201 ?Cataract 41, 116400 (3) AD;Deafness, AD 6/14/38, 600965 (3) AD;Wolfram syndrome 1, 222300 (3) AR;Wolfram-like syndrome, AD, 614296 (3) AD;(Diabetes mellitus, noninsulin-dependent, association with), 125853 (3) AD AD;AR yes yes 9 1.6231e-38 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 PPP2R2C NM_020416 4 6322307 6474341 152034 1344 100 no 9 txStart-txEnd 5'UTR-3'UTR 6322307 6474341 dbVar chr4:5960239-6587328 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 772379;26138;592497;772380;448916;195136;195737;195780;320366;772381;97607;93866;840298;434816;74069;277029;373837;547730;460364;1004835;869945;250336;311600;547731;772386;772387;772388;422017;416592;807978;20850;28306;416593;1027612;1027638;1027613 loss;gain 50.29 0.338434929038259 0.422718688109719 0.476236130280707 -0.54023780146542 4.10111380803453 5522 1 8.9954e-01 5.6445e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MAN2B2 NM_015274 3 6576915 6625089 48174 3030 100 no 19 txStart-txEnd 5'UTR-3'UTR 6576915 6625089 dbVar chr4:6438729-6651391 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 311602;472835;322698;302039;224062;224313;289114 loss;gain 83.66 -1.20308868163847 -0.039423685654856 -0.514512683951566 0.311204487601666 -0.733522379663636 23324 5 6.5570e-23 4.3573e-18 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MRFAP1 NM_001272053 2 6642411 6644456 2045 384 96 no 3 txStart-txEnd 5'UTR-3'UTR 6642411 6644456 dbVar chr4:6438729-6651391 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 78.84 0.686792213866423 0.236901723651345 0.49521306481059 0.837271434822507 2.12628699887071 93621 6 3.1404e-01 1.7706e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02482 NR_134664 1 6672454 6675608 3154 0 0 no 2 txStart-txEnd UTR 6672454 6675608 dbVar chr4:6666000-6686000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 105374366 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LOC93622 NM_138699 3 6675801 6677774 1973 360 19 no 1 txStart-txEnd 5'UTR-3'UTR 6675801 6677774 dbVar chr4:6666000-6686000 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02481 NR_147207 1 6689174 6692246 3072 0 0 no 3 txStart-txEnd UTR 6689174 6692246 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 339988 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 S100P NM_005980 3 6695604 6698897 3293 288 100 no 2 txStart-txEnd 5'UTR-3'UTR 6695604 6698897 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 89.8 -0.0213485169134644 -0.684657921159283 -0.478383965590741 0.251281715605183 -0.615839346409602 6286 9 3.3257e-02 4.8649e-02 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MRFAP1L1 NM_203462 3 6709427 6711592 2165 384 61 no 2 txStart-txEnd 5'UTR-3'UTR 6709427 6711592 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 84.97 0.629248196007981 0.195831367621135 0.447874019110796 1.72296511806951 0.620681882628763 114932 8 2.5481e-03 8.9080e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 BLOC1S4 NM_018366 3 6717900 6719391 1491 654 44 no 1 txStart-txEnd 5'UTR-3'UTR 6717900 6719391 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 72.47 2.75338717063303 1.98938453238048 55330 9 1.0151e-01 1.5897e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 KIAA0232 NM_001100590 2 6784453 6885891 101438 4188 100 no 9 txStart-txEnd 5'UTR-3'UTR 6784453 6885891 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 298845;1059518;1059219;1071711;264160 loss;gain 62.19 0.495223937339359 -0.201270287076057 0.0915777485634488 -1.04317795810088 0.185259378880778 9778 0 9.9999e-01 9.9472e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 TBC1D14 NM_001113361 2 6911192 7034841 123649 2082 100 no 14 txStart-txEnd 5'UTR-3'UTR 6911192 7034841 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 264163;701807;1108591;2537136;2856302;779357 gain;loss 58.66 0.38643088540431 0.788716334548764 0.774883176364413 -0.521938260031064 1.10884704568458 57533 2 3.9267e-02 9.0900e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LOC100129931 NR_033828 1 7032280 7047958 15678 0 0 no 4 txStart-txEnd UTR 7032280 7047958 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 CCDC96 NM_153376 3 7042575 7044728 2153 1668 96 no 1 txStart-txEnd 5'UTR-3'UTR 7042575 7044728 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 88.85 0.393108310742818 -0.13797094617163 0.0809738518294932 3.25348988684008 1.81654247561098 257236 8 1.9555e-17 2.7054e-06 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 TADA2B NM_152293 3 7045098 7059679 14581 1263 100 no 2 txStart-txEnd 5'UTR-3'UTR 7045098 7059679 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 53.19 0.052084742182682 -0.284361515719772 -0.145832700564166 0.664832774210228 4.02698047878354 93624 2 7.2366e-01 3.4506e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 GRPEL1 NM_025196 4 7060621 7069791 9170 654 100 no 4 txStart-txEnd 5'UTR-3'UTR 7060621 7069791 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 50.3 0.649976625334672 -1.27240513662323 -0.777477966060391 0.934834224809331 0.303907421223287 80273 4 1.3916e-01 8.9627e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02447 NR_027441 1 7099150 7105103 5953 0 0 no 2 txStart-txEnd UTR 7099150 7105103 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 730971 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 SORCS2 NM_020777 3 7194264 7744554 550290 3480 100 no 27 txStart-txEnd 5'UTR-3'UTR 7194264 7744554 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 372513;823599;161883;503561;853492;204368;877114;187631;195150;703389;678715;1024160;681398;1033262;439738;216115;165467;247336;474019;182774;175720;334872;853493;1515797;75031;916310;224071;251816;418845;916638;372515;204369;334873;111501;225997;378170;295196;133563;836384;98537;807982;224072;220017;264172;277088;243354;277089;554157;264173;563883;823600;... loss;gain 69.5 1.29231994213647 0.27620541213653 0.660060919341019 -1.05139548669208 0.853955018782722 57537 2 3.1696e-03 2.6463e-03 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MIR4798 NR_039961 1 7312176 7312251 75 0 0 no 1 txStart-txEnd UTR 7312176 7312251 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 100616471 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 PSAPL1 NM_001085382 2 7432011 7436657 4646 1566 96 no 1 txStart-txEnd 5'UTR-3'UTR 7432011 7436657 dbVar chr4:7313592-7549020 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 295197;122148;196395;79107 loss 96.06 -0.246463271906552 -0.572766431683099 -0.498050358907741 -1.4518704411588 -1.9222533414192 768239 3.3350e-11 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MIR4274 NR_036238 1 7461754 7461845 91 0 0 no 1 txStart-txEnd UTR 7461754 7461845 dbVar chr4:7313592-7549020 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 100422826 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 AFAP1-AS1 NR_026892 1 7755816 7780655 24839 0 0 no 2 txStart-txEnd UTR 7755816 7780655 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 743912;1040482;385542 gain;loss 84740 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 AFAP1 NM_001134647 2 7760440 7941588 181148 2445 100 no 18 txStart-txEnd 5'UTR-3'UTR 7760440 7941588 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 1040482;385542;311610;6749;398628;772488;324492;20869;4192;3063870;984963;964781;11263;1004855;414207;445352;257540;788203;772490;772491;1038263 loss;gain 70.06 -2.62354415217069 -0.232673834093773 -1.98456571684452 -1.13990389227529 -0.987321027475765 60312 3 2.3828e-07 3.7607e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LOC389199 NR_172651 1 7940727 7942023 1296 0 0 no 1 txStart-txEnd UTR 7940727 7942023 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 ABLIM2 NM_001130083 2 7967053 8160540 193487 1938 100 no 21 txStart-txEnd 5'UTR-3'UTR 7967053 8160540 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 160939;946073;946097;946100;946101;946104;946109;334878;1038265;4194;601329;344716;340173;599925;1010175;98540;311613;312165;312176;312239;743922;250340;858346;22003;582548;1010176;24486;334879;793318;99137;99271;99276;1030022;2281227;1033276;1034399;1034400;311614;312201;507701;1033277;1034389;743925;743926;772517 loss;gain 63.64 0.337838438332487 -0.499016330621921 -0.246989921895573 -1.59029981969928 -1.42113131036961 84448 2 4.5858e-03 7.6242e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 MIR95 NR_029511 1 8007027 8007108 81 0 0 no 1 txStart-txEnd UTR 8007027 8007108 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 407052 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 SH3TC1 NM_018986 5 8201016 8242830 41814 4011 100 no 18 txStart-txEnd 5'UTR-3'UTR 8201016 8242830 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 78131;78439;291676;1012930;577741;13870;118350;359767;320384;1013744;1013904;1013914;1013932;329674;580198;358565;427997;22833;22834 loss;gain 89.77 -0.370323251116391 -0.462112374732113 -0.471672769326771 -2.08522134689875 -3.42040819381878 54436 7 6.0939e-35 1.0820e-27 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 HTRA3 NM_053044 5 8271480 8308825 37345 1362 100 no 9 txStart-txEnd 5'UTR-3'UTR 8271480 8308825 morbid:HTRA3 4:8271481-8308825 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 414213;414674;772523 gain;loss 70.02 -0.536935947037787 -0.623131034083341 -0.644700690991608 0.667359866413857 1.21754776737995 726 yes 6 6.5843e-08 1.7199e-05 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 LINC02517 NR_149125 1 8321902 8325692 3790 0 0 no 4 txStart-txEnd UTR 8321902 8325692 dbVar chr4:8311538-8373454 0.01 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 105374374 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 ACOX3 NM_003501 3 8368008 8442450 74442 2103 100 no 18 txStart-txEnd 5'UTR-3'UTR 8368008 8442450 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 1812851;1040498;1028616;2137816 loss;gain 82.99 -2.37227679543374 -0.95101441383295 -1.44715983267575 -0.00424238497735845 -0.527819209746206 8310 5 7.6016e-16 3.0316e-12 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 TRMT44 NM_152544 3 8442503 8478282 35779 2274 100 no 11 txStart-txEnd 5'UTR-3'UTR 8442503 8478282 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 1028618;1028622 gain;loss 87.71 -2.36525961978995 -1.15479952515637 -1.59282400997772 -0.488109075837714 -1.79889045378054 152992 7 2.0315e-22 1.4776e-13 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 GPR78 NM_080819 5 8582118 8591750 9632 1092 100 no 3 txStart-txEnd 5'UTR-3'UTR 8582118 8591750 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 277176 loss 91.64 -2.62354415217069 -1.33186842996177 -1.94147419136763 -0.663631774481401 -1.44235869751468 27201 9 2.6834e-06 1.2826e-05 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 CPZ NM_001014447 3 8594491 8621479 26988 1959 100 no 11 txStart-txEnd 5'UTR-3'UTR 8594491 8621479 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 772553;105310;105731;105769;105787 loss 75.68 -2.62354415217069 -1.41032367542656 -1.95519140378666 -2.6391793475309 -5.33339017829433 8532 9 8.8063e-36 4.5080e-21 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 HMX1 NM_018942 3 8868773 8873565 4792 1047 100 no 2 txStart-txEnd 5'UTR-3'UTR 8868773 8873565 Oculoauricular syndrome, 612109 (3) AR morbid:HMX1 4:8868774-8873565 1 Isolated_microphthalmia_6 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444;4:4041723-9068132;4:4151586-8958950 0.1474 66.38 1.46868520416757 1.8176765127262 oculoauricular syndrome AR Definitive;Strong;Supportive 18423520;18423520[PMID]_25574057[PMID];19379485;25574057;29140751 3166 142992 Oculoauricular syndrome, 612109 (3) AR AR yes 3 7.2623e-01 1.2528e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 FAM90A26 NM_001358418 3 9172134 9178456 6322 1395 100 no 7 txStart-txEnd 5'UTR-3'UTR 9172134 9178456 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174;gnomAD-SV_v2.1_DUP_4_11182 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;4:9099000-9212000;chr4:9140852-9677036 0.5978 1000g;DDD:12912;DDD:12915;dbVar;dgv923e199;esv3599566 4:9043826-9467101;chr4:9157568-9214307;4:9157569-9214307;4:9157569-9214307;4:9158155-9232046;4:9160215-9232041 1.0000 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 98.14 100287045 9 2.8656e-01 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L10 NM_001256852 1 9212382 9213975 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9212382 9213975 DDD:12912;DDD:12919;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;4:9176165-9236152;chr4:9181620-9274560 0.5978 1000g;DDD:12912;DDD:12915;DDD:12919;dbVar;dgv923e199;esv3599566 4:9043826-9467101;chr4:9157568-9214307;4:9157569-9214307;4:9157569-9214307;4:9158155-9232046;4:9160215-9232041;4:9176165-9236152 1.0000 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 88.87 100287144 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L11 NM_001256854 1 9217130 9218723 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9217130 9218723 DDD:12912;DDD:12919;DDD:12922;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;4:9176165-9236152;chr4:9181620-9274560;4:9212771-9237062 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9043826-9467101;4:9158155-9232046;4:9160215-9232041;4:9176165-9236152;4:9212771-9237062 1.0000 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 92.38 100287178 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L12 NM_001256853 1 9221877 9223470 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9221877 9223470 DDD:12912;DDD:12919;DDD:12922;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;4:9176165-9236152;chr4:9181620-9274560;4:9212771-9237062 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9043826-9467101;4:9158155-9232046;4:9160215-9232041;4:9176165-9236152;4:9212771-9237062 1.0000 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 91.28 100287205 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L13 NM_001256855 1 9226621 9228214 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9226621 9228214 DDD:12912;DDD:12919;DDD:12922;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;4:9176165-9236152;chr4:9181620-9274560;4:9212771-9237062 0.5978 DDD:12912;DDD:12915;DDD:12919;DDD:12922;dgv923e199 4:9043826-9467101;4:9158155-9232046;4:9160215-9232041;4:9176165-9236152;4:9212771-9237062 1.0000 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 93.57 100287238 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L15 NM_001256894 2 9236110 9237772 1662 1662 100 no 1 txStart-txEnd 5'UTR-3'UTR 9236110 9237772 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 88.6 100288520 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L17 NM_001256857 1 9245604 9247197 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9245604 9247197 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 91.84 100287327 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L18 NM_001256859 1 9250355 9251948 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9250355 9251948 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 91.4 100287364 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L19 NM_001256860 1 9255103 9256696 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9255103 9256696 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 89.82 100287404 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L20 NM_001256861 1 9259849 9261442 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9259849 9261442 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 92.3 100287441 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L21 NM_001256862 1 9264597 9266190 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9264597 9266190 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 93.14 100287478 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L22 NM_001256863 1 9269344 9270937 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9269344 9270937 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8942468-9274560;chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9181620-9274560 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 90.3 100287513 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L24 NM_001242327 1 9326890 9328483 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9326890 9328483 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 94.26 728369 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L25 NM_001242326 1 9331636 9333229 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9331636 9333229 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 92.83 728373 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L26 NM_001242328 1 9336383 9337976 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9336383 9337976 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 92.3 728379 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L5 NM_001242329 1 9341128 9342721 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9341128 9342721 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 93.97 728386 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L27 NM_001242330 1 9345873 9347466 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9345873 9347466 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 94.31 728393 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L28 NM_001242331 1 9350618 9352211 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9350618 9352211 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 95.78 728400 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L29 NM_001242332 1 9355363 9356956 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9355363 9356956 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 94.78 728405 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L9P NR_046416 1 9360107 9361700 1593 0 0 no 1 txStart-txEnd UTR 9360107 9361700 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 391627 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L30 NM_001256867 1 9364854 9366447 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 9364854 9366447 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 94.83 728419 full=5 +4_71553_9371067_DEL_1 4 71553 9371067 -9299514 DEL 4p- syndrom Pathogenic NA split p16.1 USP17L6P NR_027279 1 9369599 9370796 1197 0 0 no 1 txStart-txEnd UTR 9369599 9370796 DDD:12912;IMH;dbVar;gnomAD-SV_v2.1_DUP_4_11165;gnomAD-SV_v2.1_DUP_4_11169;gnomAD-SV_v2.1_DUP_4_11170;gnomAD-SV_v2.1_DUP_4_11174 chr4:8951531-9485561;4:8951722-9487283;chr4:8952199-9486394;4:8952199-9486394;chr4:8958204-9492295;4:8958204-9492295;4:8959918-9493802;chr4:9009830-9541289;4:9009830-9541289;4:9043826-9467101;chr4:9140852-9677036;chr4:9324760-9371594;chr4:9324760-9423525;chr4:9324760-9617830 0.5978 DDD:12912 4:9043826-9467101 0.0130 IMH 4:2823210-17706072;4:4005753-9642302;4:4006353-9641444 0.1474 391622 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA full q11.23 TRIM50;FKBP6;FZD9;BAZ1B;BCL7B;TBL2;MLXIPL;VPS37D;DNAJC30;BUD23;STX1A;MIR4284;ABHD11-AS1;ABHD11;CLDN3;CLDN4;METTL27;TMEM270;ELN;LIMK1;EIF4H;MIR590;LAT2;RFC2;CLIP2;GTF2IRD1;MIR10525;GTF2I;GTF2I-AS1 NSUN5 NCF1 29 ACOX1 (morbid/RE=mTL_miRNA);ACSL6 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AGTPBP1 (morbid/RE=mTL_miRNA);AKR1D1 (morbid/RE=mTL_miRNA);ALDH6A1 (morbid/RE=mTL_miRNA);ALDOA (morbid/RE=mTL_miRNA);APC (HI=3/morbid/RE=mTL_miRNA);APTX (morbid/RE=mTL_miRNA);ARSK (morbid/RE=mTL_miRNA);ATL3 (morbid/RE=mTL_miRNA);ATP13A3 (morbid/RE=mTL_miRNA);ATP6V0A2 (morbid/RE=mTL_miRNA);ATP6V1A (morbid/RE=mTL_miRNA);ATXN1 (morbid/RE=mTL_miRNA);BACH1 (morbid/RE=mTL_miRNA);BVES (morbid/RE=mTL_miRNA);C3 (morbid/RE=mTL_miRNA);CAPN15 (morbid/RE=mTL_miRNA);CASP10 (morbid/RE=mTL_miRNA);CD3D (morbid/RE=mTL_miRNA);CDC73 (HI=3/morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CHRNB1 (morbid/RE=mTL_miRNA);CISD2 (morbid/RE=mTL_miRNA);CITED2 (morbid/RE=mTL_miRNA);CLEC7A (morbid/RE=mTL_miRNA);CLN8 (morbid/RE=mTL_miRNA);COL18A1 (morbid/RE=mTL_miRNA);COX20 (morbid/RE=mTL_miRNA);COX6B1 (morbid/RE=mTL_miRNA);CPE (morbid/RE=mTL_miRNA);CPT1A (morbid/RE=mTL_miRNA);CRIPT (morbid/RE=mTL_miRNA);CRTAP (morbid/RE=mTL_miRNA);CSNK1D (morbid/RE=mTL_miRNA);CTSB (morbid/RE=mTL_miRNA);CYCS (morbid/RE=mTL_miRNA);DARS2 (morbid/RE=mTL_miRNA);DBR1 (morbid/RE=mTL_miRNA);DNA2 (morbid/RE=mTL_miRNA);DNAAF3 (morbid/RE=mTL_miRNA);DNAJB13 (morbid/RE=mTL_miRNA);DNAJC3 (morbid/RE=mTL_miRNA);DSG3 (morbid/RE=mTL_miRNA);EDARADD (morbid/RE=mTL_miRNA);EIF2S3 (morbid/RE=mTL_miRNA);EIF4A2 (morbid/RE=mTL_miRNA);ELP2 (morbid/RE=mTL_miRNA);EMP2 (morbid/RE=mTL_miRNA);EPB41 (morbid/RE=mTL_miRNA);EPB42 (morbid/RE=mTL_miRNA);EPG5 (morbid/RE=mTL_miRNA);EXOSC2 (morbid/RE=mTL_miRNA);FANCF (morbid/RE=mTL_miRNA);FARSB (morbid/RE=mTL_miRNA);FBXW7 (morbid/RE=mTL_miRNA);FGF12 (morbid/RE=mTL_miRNA);FGFR1 (HI=3/morbid/RE=mTL_miRNA);FLCN (HI=3/morbid/RE=mTL_miRNA);FOXG1 (HI=3/morbid/RE=mTL_miRNA);FXN (morbid/RE=mTL_miRNA);GABRB3 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GATAD2B (HI=3/morbid/RE=mTL_miRNA);GBA2 (morbid/RE=mTL_miRNA);GFPT1 (morbid/RE=mTL_miRNA);GGCX (morbid/RE=mTL_miRNA);GNAQ (morbid/RE=mTL_miRNA);GNB4 (morbid/RE=mTL_miRNA);GPC4 (morbid/RE=mTL_miRNA);GSR (morbid/RE=mTL_miRNA);HEXA (morbid/RE=mTL_miRNA);HINT1 (morbid/RE=mTL_miRNA);HNRNPA1 (morbid/RE=mTL_miRNA);HNRNPK (HI=3/morbid/RE=mTL_miRNA);IDS (HI=3/morbid/RE=mTL_miRNA);IFT74 (morbid/RE=mTL_miRNA);IGF1 (morbid/RE=mTL_miRNA);IGF2R (morbid/RE=mTL_miRNA);IL10RB (morbid/RE=mTL_miRNA);IL12B (morbid/RE=mTL_miRNA);IL6R (morbid/RE=mTL_miRNA);IL6ST (morbid/RE=mTL_miRNA);ING1 (morbid/RE=mTL_miRNA);IREB2 (morbid/RE=mTL_miRNA);ITGB3 (morbid/RE=mTL_miRNA);JPH2 (morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNJ5 (morbid/RE=mTL_miRNA);KCNJ6 (morbid/RE=mTL_miRNA);KIF1C (morbid/RE=mTL_miRNA);KLHL15 (morbid/RE=mTL_miRNA);KLHL7 (morbid/RE=mTL_miRNA);KLLN (morbid/RE=mTL_miRNA);KMT5B (HI=3/morbid/RE=mTL_miRNA);KREMEN1 (morbid/RE=mTL_miRNA);LDHA (morbid/RE=mTL_miRNA);LDLR (HI=3/morbid/RE=mTL_miRNA);LIAS (morbid/RE=mTL_miRNA);LMBRD2 (morbid/RE=mTL_miRNA);LRIG2 (morbid/RE=mTL_miRNA);LYRM7 (morbid/RE=mTL_miRNA);MALT1 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MCM4 (morbid/RE=mTL_miRNA);MCM9 (morbid/RE=mTL_miRNA);MDH2 (morbid/RE=ABC_enhancer);MED13 (morbid/RE=mTL_miRNA);MED13L (HI=3/morbid/RE=mTL_miRNA);MED17 (morbid/RE=mTL_miRNA);MESD (morbid/RE=mTL_miRNA);MIB1 (morbid/RE=mTL_miRNA);MRPS16 (morbid/RE=mTL_miRNA);MSH3 (morbid/RE=mTL_miRNA);MXI1 (morbid/RE=mTL_miRNA);MYH9 (morbid/RE=mTL_miRNA);MYPN (morbid/RE=mTL_miRNA);NAA15 (HI=3/morbid/RE=mTL_miRNA);NCF1 (morbid/RE=EA_enhancer+GH_enhancer+GH_promoter_enhancer);NCKAP1 (HI=3/RE=mTL_miRNA);NDRG1 (morbid/RE=mTL_miRNA);NDUFA12 (morbid/RE=mTL_miRNA);NECTIN4 (morbid/RE=mTL_miRNA);NFIB (morbid/RE=mTL_miRNA);NHLRC2 (morbid/RE=mTL_miRNA);NHS (HI=3/morbid/RE=mTL_miRNA);NIPA1 (morbid/RE=mTL_miRNA);NKAP (morbid/RE=mTL_miRNA);NMNAT1 (morbid/RE=mTL_miRNA);NR3C1 (morbid/RE=mTL_miRNA);NUP133 (morbid/RE=mTL_miRNA);ORC4 (morbid/RE=mTL_miRNA);ORC6 (morbid/RE=mTL_miRNA);OSBPL2 (morbid/RE=mTL_miRNA);OSMR (morbid/RE=mTL_miRNA);PACS1 (morbid/RE=mTL_miRNA);PACS2 (morbid/RE=mTL_miRNA);PAH (morbid/RE=mTL_miRNA);PDE11A (morbid/RE=mTL_miRNA);PEX13 (morbid/RE=mTL_miRNA);PEX2 (morbid/RE=mTL_miRNA);PGAP1 (morbid/RE=mTL_miRNA);PHEX (HI=3/morbid/RE=mTL_miRNA);PHKG2 (morbid/RE=mTL_miRNA);PIGA (morbid/RE=mTL_miRNA);PIGM (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);PLA2G4A (morbid/RE=mTL_miRNA);PLA2G7 (morbid/RE=mTL_miRNA);PMPCA (morbid/RE=mTL_miRNA);PNPT1 (morbid/RE=mTL_miRNA);POC1A (morbid/RE=mTL_miRNA);POGZ (HI=3/morbid/RE=mTL_miRNA);POLR1B (morbid/RE=mTL_miRNA);POLR3A (morbid/RE=mTL_miRNA);PPM1D (morbid/RE=mTL_miRNA);PPP1R15B (morbid/RE=mTL_miRNA);PPP2R1A (morbid/RE=mTL_miRNA);PRICKLE1 (morbid/RE=mTL_miRNA);PRKCA (morbid/RE=mTL_miRNA);PRPF4 (morbid/RE=mTL_miRNA);PRPF6 (morbid/RE=mTL_miRNA);PTCD3 (morbid/RE=mTL_miRNA);PTGIS (morbid/RE=mTL_miRNA);PTPN14 (morbid/RE=mTL_miRNA);PYROXD1 (morbid/RE=mTL_miRNA);QRSL1 (morbid/RE=mTL_miRNA);RAB27A (morbid/RE=mTL_miRNA);RAD51 (morbid/RE=mTL_miRNA);RB1 (HI=3/morbid/RE=mTL_miRNA);RILPL1 (morbid/RE=mTL_miRNA);RNF2 (morbid/RE=mTL_miRNA);RNF6 (morbid/RE=mTL_miRNA);RPL15 (morbid/RE=mTL_miRNA);RSPH3 (morbid/RE=mTL_miRNA);RSRC1 (morbid/RE=mTL_miRNA);SBDS (morbid/RE=mTL_miRNA);SCARB2 (morbid/RE=mTL_miRNA);SCO1 (morbid/RE=mTL_miRNA);SCUBE3 (morbid/RE=mTL_miRNA);SEC23B (morbid/RE=mTL_miRNA);SELENOI (morbid/RE=mTL_miRNA);SERPING1 (morbid/RE=mTL_miRNA);SETD1B (morbid/RE=mTL_miRNA);SETD5 (HI=3/morbid/RE=mTL_miRNA);SF3B1 (morbid/RE=mTL_miRNA);SGCB (morbid/RE=mTL_miRNA);SGPL1 (morbid/RE=mTL_miRNA);SHOC2 (morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC19A3 (morbid/RE=mTL_miRNA);SLC1A2 (morbid/RE=mTL_miRNA);SLC25A4 (morbid/RE=mTL_miRNA);SLC25A46 (morbid/RE=mTL_miRNA);SLC33A1 (morbid/RE=mTL_miRNA);SLC9A7 (morbid/RE=mTL_miRNA);SMAD3 (HI=3/morbid/RE=mTL_miRNA);SORD (morbid/RE=mTL_miRNA);SP110 (morbid/RE=mTL_miRNA);SPN (morbid/RE=mTL_miRNA);SPPL2A (morbid/RE=mTL_miRNA);SPRY4 (morbid/RE=mTL_miRNA);STIL (morbid/RE=mTL_miRNA);STK4 (morbid/RE=mTL_miRNA);STX16 (morbid/RE=mTL_miRNA);STXBP2 (morbid/RE=mTL_miRNA);TAF1 (morbid/RE=mTL_miRNA);TAF8 (morbid/RE=mTL_miRNA);TAOK1 (HI=3/morbid/RE=mTL_miRNA);TBX18 (morbid/RE=mTL_miRNA);TCN2 (morbid/RE=mTL_miRNA);TET2 (morbid/RE=mTL_miRNA);TGFB1 (morbid/RE=mTL_miRNA);TGFBR2 (morbid/RE=mTL_miRNA);THG1L (morbid/RE=mTL_miRNA);TIMM8A (HI=3/morbid/RE=mTL_miRNA);TMEM216 (morbid/RE=mTL_miRNA);TMEM70 (morbid/RE=mTL_miRNA);TNFRSF11A (morbid/RE=mTL_miRNA);TNFRSF13B (morbid/RE=mTL_miRNA);TNPO3 (morbid/RE=mTL_miRNA);TRAF3IP1 (morbid/RE=mTL_miRNA);TRPM6 (morbid/RE=mTL_miRNA);TRPS1 (HI=3/morbid/RE=mTL_miRNA);TTR (morbid/RE=mTL_miRNA);UGDH (morbid/RE=mTL_miRNA);UQCRB (morbid/RE=mTL_miRNA);WAC (HI=3/morbid/RE=mTL_miRNA);WEE2 (morbid/RE=mTL_miRNA);WNK1 (morbid/RE=mTL_miRNA);XIAP (HI=3/morbid/RE=mTL_miRNA);XPNPEP3 (morbid/RE=mTL_miRNA);XRCC2 (morbid/RE=mTL_miRNA);YIPF5 (morbid/RE=mTL_miRNA);YRDC (morbid/RE=mTL_miRNA);ZBTB16 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA);ZBTB7A (morbid/RE=mTL_miRNA);ZEB1 (morbid/RE=mTL_miRNA);ZEB2 (HI=3/morbid/RE=mTL_miRNA) dbVar:nssv15146175;nssv15148276;dbVar:nssv15146450;dbVar:nssv15147327;dbVar:nssv17955524;dbVar:nssv17976654 7:72766114-74133473;7:72766313-74133327;7:72766314-74042787;7:72766314-74133332;7:73944169-74138459 Cutis laxa, AD, 123700 (3) AD;Supravalvar aortic stenosis, 185500 (3) AD;Leber-like hereditary optic neuropathy, AR 1, 619382 (3) AR;Spermatogenic failure 77, 620103 (3) AR HI3:ELN;dbVar:nssv15128343;dbVar:nssv15128578;dbVar:nssv15130113;dbVar:nssv15130169;dbVar:nssv15140244;dbVar:nssv15141480;dbVar:nssv15145649;nssv15146804;nssv15153080;dbVar:nssv15146451;dbVar:nssv15146687;dbVar:nssv15146708;dbVar:nssv15151951;nssv15605841;dbVar:nssv15167740;dbVar:nssv15770120;dbVar:nssv16208140;dbVar:nssv16213814;dbVar:nssv16214480;dbVar:nssv16214500;dbVar:nssv17172745;dbVar:nssv17172746;dbVar:nssv17955650;dbVar:nssv17971140;dbVar:nssv18786274;dbVar:nssv18791884;dbVar:nssv18791887;morbid:DNAJC30;morbid:ELN;morbid:FKBP6 7:72726579-74139390;7:72742164-72772634;7:72766114-74133473;7:72766313-74133327;7:72766314-74133332;7:72772523-74133319;7:72996565-73597315;7:73023063-73524207;7:73095248-73097783;7:73150890-73604636;7:73187644-73501025;7:73442120-73484237;7:73442459-73483087;7:73442499-73442619;7:73442499-73483050;7:73442503-73484237;7:73442509-73483040;7:73442519-73449764;7:73442519-73483030;7:73444331-73476493;7:73449675-73483050;7:73461986-73483030;7:73470471-73498327;7:73471703-73483040;7:73482968-73483050;7:73482988-73484237;7:73791726-74133273 7q11.23 recurrent (Williams-Beuren syndrome) region (includes ELN) dbVar:nssv15777247;dbVar:nssv15168013;dbVar:nssv15161666;nssv15161679;dbVar:nssv15168014;dbVar:nssv15146013;dbVar:nssv15146778;dbVar:nssv15147714;dbVar:nssv15147012;dbVar:nssv15147013;dbVar:nssv15755212;dbVar:nssv15147334;dbVar:nssv15151509;dbVar:nssv15154519;dbVar:nssv15152109;dbVar:nssv15153678;dbVar:nssv15148173;dbVar:nssv15149887;dbVar:nssv15147399;dbVar:nssv15148904;dbVar:nssv15174166;dbVar:nssv15128409;dbVar:nssv15150793;dbVar:nssv16254014;dbVar:nssv15148877;dbVar:nssv18830985;dbVar:nssv15147014;dbVar:nssv15149513;dbVar:nssv15146773;dbVar:nssv15151227;dbVar:nssv15147017;dbVar:nssv15146395;dbVar:nssv15147458;dbVar:nssv15126184;dbVar:nssv17976854;dbVar:nssv15150228;dbVar:nssv15147556;dbVar:nssv15146449;dbVar:nssv15151508;dbVar:nssv15150733;dbVar:nssv15154518;dbVar:nssv17955880;dbVar:nssv18830970;dbVar:nssv15146933;dbVar:nssv16215249;dbVar:nssv15167739;TS3:ISCA-37392;dbVar:nssv15148970 7:10366-159119707;7:10705-159122532;7:43362-159119707;7:44936-159126310;7:62437464-75044630;7:71644078-78793387;7:71968213-74133332;7:72196406-74991125;7:72233836-74285345;7:72364527-73780265;7:72408603-74193374;7:72576873-74175429;7:72577022-74147166;7:72577022-74197846;7:72577022-74859638;7:72589516-74154603;7:72589516-74165401;7:72606410-74193403;7:72606410-74300084;7:72606451-74153206;7:72650008-74188572;7:72659675-74143240;7:72659675-74164894;7:72663963-74193403;7:72664462-74162586;7:72665463-74139573;7:72677174-74143140;7:72677302-74143060;7:72677302-74143240;7:72679398-74139573;7:72683245-74267189;7:72685735-74142327;7:72685764-74189674;7:72686959-74155067;7:72692113-74154497;7:72700128-74146858;7:72700415-74139573;7:72700525-74069858;7:72700525-74142256;7:72701019-74143240;7:72717346-74133310;7:72718278-74142256;7:72718279-74140708;7:72722982-74141840;7:72743984-74145064;7:72744456-74142510;7:72766314-74481540 0.89;0.89;0.89;0.89;11.21;19.76;64.97;50.55;68.87;74.43;79.16;88.38;89.98;87.17;61.89;90.27;89.65;89.02;83.42;91.34;91.83;95.23;93.86;92.37;94.31;95.84;96.37;96.39;96.38;96.76;89.20;96.99;93.94;96.23;96.61;97.66;98.17;98.10;97.99;97.96;99.35;99.22;99.32;99.57;99.60;99.78;80.05 7q11.23 recurrent (Williams-Beuren syndrome) region (includes ELN) dbVar:nssv15161318;dbVar:nssv15148211;dbVar:nssv15147057;dbVar:nssv15147200;dbVar:nssv16255682;dbVar:nssv15146320;dbVar:nssv15146676;dbVar:nssv16867365;dbVar:nssv15167734;dbVar:nssv15146211;dbVar:nssv16254015;dbVar:nssv15151112;dbVar:nssv15145801;dbVar:nssv15152099;dbVar:nssv17977008;dbVar:nssv15151511;dbVar:nssv17977009;dbVar:nssv15145887;dbVar:nssv15147427;dbVar:nssv15153677;dbVar:nssv15154521;dbVar:nssv16208139;dbVar:nssv15145827;dbVar:nssv15148206;dbVar:nssv15151289;dbVar:nssv18330757;dbVar:nssv15125131;dbVar:nssv17977011;dbVar:nssv15167735;dbVar:nssv15148192;dbVar:nssv15167736;dbVar:nssv15168977;dbVar:nssv18330770;dbVar:nssv16215159;dbVar:nssv15129678;dbVar:nssv15147158;dbVar:nssv15606134;dbVar:nssv15145898;dbVar:nssv15151092;dbVar:nssv15755220;dbVar:nssv17977017;dbVar:nssv15147160;dbVar:nssv15147159;dbVar:nssv15145802;dbVar:nssv15147457;dbVar:nssv15148226;dbVar:nssv15147515;dbVar:nssv15147502;dbVar:nssv15148195;dbVar:nssv15147550;dbVar:nssv17977015;dbVar:nssv15605840;dbVar:nssv17977014;dbVar:nssv15149859;dbVar:nssv17977016;dbVar:nssv15150016;dbVar:nssv15146951;dbVar:nssv16297072;dbVar:nssv18830737;dbVar:nssv15154517;nssv17977012;dbVar:nssv17977007;dbVar:nssv15146637;dbVar:nssv15149107;dbVar:nssv15150231;dbVar:nssv15150699;dbVar:nssv15150637;dbVar:nssv15151346;dbVar:nssv15148257;nssv17977121;dbVar:nssv15150643;dbVar:nssv15149860;dbVar:nssv15151090;dbVar:nssv18329614;dbVar:nssv18330419;dbVar:nssv18330223;dbVar:nssv15167737;dbVar:nssv15605774;dbVar:nssv8640006;dbVar:nssv15167738;dbVar:nssv15147726;dbVar:nssv15755221;HI3:ISCA-37392;dbVar:nssv15605838;dbVar:nssv15605839;dbVar:nssv15147324;dbVar:nssv15147329;dbVar:nssv15145670;dbVar:nssv15145679;nssv15146800;dbVar:nssv15146612;dbVar:nssv17977013;dbVar:nssv15124428;dbVar:nssv15776001;dbVar:nssv15120782;dbVar:nssv15148954;dbVar:nssv15147202 7:54186-159075079;7:62196743-75061986;7:68133295-72806397;7:68847340-77453149;7:68977231-73939510;7:70690331-81364973;7:70926113-72806397;7:71847969-73391310;7:72305672-74196360;7:72401087-74285345;7:72403118-76709600;7:72456605-76007380;7:72507130-74142327;7:72536981-74629034;7:72589196-74225562;7:72589516-74386749;7:72589516-74629034;7:72606410-74193403;7:72606410-74285345;7:72608515-74386749;7:72612043-74574641;7:72621723-76007380;7:72636007-74339014;7:72637825-74203685;7:72643632-74142190;7:72643633-74143060;7:72644632-74144422;7:72645014-74142190;7:72650107-74138603;7:72650121-74142256;7:72650266-74138603;7:72653307-74134911;7:72654783-74142190;7:72657229-74160300;7:72677238-74144422;7:72681398-74137354;7:72682339-74141250;7:72685735-74142327;7:72691243-74142190;7:72699383-74142329;7:72700128-74142190;7:72700415-74122179;7:72700415-74137354;7:72700415-74139573;7:72700415-74142327;7:72700415-74172913;7:72700415-74193403;7:72700415-74285345;7:72700511-74142190;7:72700525-74141494;7:72700943-74142190;7:72700997-74142190;7:72700997-74142256;7:72701019-74141493;7:72701085-74142190;7:72708238-74133273;7:72708238-74339044;7:72717370-74142224;7:72717396-74173168;7:72718124-74141784;7:72718124-74142190;7:72718253-74133273;7:72718253-74133332;7:72718278-73898515;7:72718278-74141494;7:72718278-74141603;7:72718278-74141746;7:72718278-74142190;7:72718278-74146858;7:72718278-74259899;7:72718278-74287433;7:72718279-74142256;7:72718279-74143060;7:72718279-74143240;7:72719387-74218536;7:72721450-73959106;7:72722982-74141840;7:72722982-74200092;7:72722982-74217390;7:72726591-74142329;7:72744456-74142510;7:72744495-74339044;7:72744495-76038818;7:72766313-74193397;7:72766313-74339030;7:72766314-74285345;7:72766314-74339044;7:72766314-76351578;7:72921551-74145628;7:73591994-75914797;7:73799887-75388031;7:73992745-74991125;7:73992745-81661058;7:73992745-83618176 0.89;10.98;1.71;16.42;24.44;13.24;4.25;43.07;74.72;74.98;32.81;39.79;86.40;67.53;86.34;78.61;69.27;89.02;84.15;79.45;71.99;41.73;82.96;90.23;94.28;94.22;94.20;94.37;94.86;94.68;94.87;95.05;94.98;93.99;96.29;96.90;96.84;96.99;97.37;97.91;97.97;98.16;98.18;98.17;97.98;95.95;94.63;89.14;98.00;98.05;98.03;98.03;98.03;98.08;98.04;98.71;86.63;99.15;97.05;99.24;99.21;99.41;99.41;99.30;99.27;99.26;99.25;99.22;98.90;91.64;90.04;99.22;99.16;99.15;94.24;99.59;99.57;95.65;94.54;99.79;99.78;87.48;42.34;96.22;87.31;90.39;87.31;38.30;99.49;23.57;21.38;14.69;1.91;1.52 104 Autism;Cutis_laxa,_autosomal_dominant_1;DNAJC30-associated_disorder;ELN-related_condition;Inborn_genetic_diseases;Intellectual_disability;Leber_hereditary_optic_neuropathy,_autosomal_recessive;Leber_optic_atrophy,_susceptibility_to;Male_infertility;Spermatogenic_failure_77;Supravalvar_aortic_stenosis;Williams_syndrome IMH 7:66631329-143298938;7:67635774-98083201 0.5000 chr7:72708999-74058000 dbVar;chr7:72726800-72740359 dbVar;chr7:72745614-72754503 dbVar;chr7:72774000-72782000 dbVar;chr7:72787000-72831100 dbVar;chr7:72816500-72830000 dbVar;chr7:72970000-72975000 dbVar;chr7:73014621-73015093 dbVar;chr7:73056768-73064674 dbVar;chr7:73220636-73223168 dbVar;chr7:73267370-73271012 dbVar;chr7:73283850-73286300 dbVar;chr7:73331000-73347000 dbVar;chr7:73432596-73433429 dbVar;chr7:73542648-73543250 dbVar;chr7:73581149-73582488 dbVar;chr7:73628409-73628785 dbVar;chr7:73660000-73666300 dbVar;chr7:73686041-73691825 dbVar;chr7:73815308-73815574 dbVar;chr7:73838366-73856516 dbVar... chr7:72400589-72727075 dbVar;chr7:72719000-72789000 dbVar;chr7:72729000-72748000 dbVar;chr7:72767887-72767960 dbVar;chr7:72783612-72807457 dbVar;chr7:72811900-72819000 dbVar;7:72893440-72893440 1000g;chr7:72998471-72999058 dbVar;chr7:73055007-73067523 dbVar;chr7:73197500-73235415 dbVar;chr7:73225900-73232279 dbVar;chr7:73276238-73276581 dbVar;chr7:73299213-73301668 dbVar;chr7:73393992-73394499 dbVar;chr7:73499000-73506000 dbVar;chr7:73546829-73546880 dbVar;chr7:73583293-73584013 dbVar;chr7:73658948-73659640 dbVar;chr7:73674630-73681367 dbVar;chr7:73787553-73825589 dbVar;chr7:73831000-73836000 dbVar... chr7:72788610-72788928 dbVar;chr7:72792927-72794734 dbVar;chr7:72807457-72811747 dbVar;chr7:72809374-72811765 dbVar;chr7:72831507-72833102 dbVar;chr7:72831655-72833172 dbVar;7:72859067-72859930 DDD:24502;chr7:72859126-72859948 dbVar;chr7:72958486-72958582 dbVar;chr7:72976072-72983729 dbVar;chr7:73003322-73003446 dbVar;chr7:73047101-73047474 dbVar;chr7:73062999-73081000 dbVar;chr7:73072977-73073093 dbVar;chr7:73106347-73106427 dbVar;chr7:73157999-73206000 dbVar;chr7:73190196-73190548 dbVar;chr7:73196830-73198271 dbVar;chr7:73211482-73211654 dbVar;chr7:73223050-73223264 dbVar;chr7:73226187-73237313 dbVar... chr7:72783921-72784587 dbVar;chr7:72790491-72790586 dbVar;chr7:72806431-72813279 dbVar;chr7:72809373-72811754 dbVar;7:72809386-72811787 DDD:24500;7:72831554-72833141 DDD:24501;chr7:72850871-72854146 dbVar;chr7:72859093-72859952 dbVar;chr7:72955017-72955274 dbVar;chr7:72962422-72963182 dbVar;chr7:73002815-73002896 dbVar;chr7:73023279-73023954 dbVar;chr7:73054513-73055107 dbVar;chr7:73065479-73067124 dbVar;chr7:73090809-73093167 dbVar;chr7:73146454-73146754 dbVar;chr7:73173329-73173399 dbVar;chr7:73196779-73198220 dbVar;chr7:73211482-73211632 dbVar;chr7:73222000-73236000 dbVar;chr7:73223135-73224193 dbVar... 877501;108118;324755;325086;500342;500863;500908;302773;303106;303125;484486;484953;484961;484998;485028;554297;554388;554400;554408;554410;554411;554412;652674;513717;232773;232999;491805;491889;491904;622919;622936;79946;80091;80098;80110;1189277;1371704;2784756;838538;280114;281928;282158;844585;730219;575489;575912;575922;575950;576011;576029;477922;... gain;loss 0.370 0.355 7:72726181-72726486 AluSz 7:72700438-72744454;7:72700443-72744454 3 88.46 1.77201404347458 0.0159631069818757 0.491444562429841 2.70903614483931 4.23220859072885 604839;618202;130160 yes 0 1.0000e+00 1.0000e+00 1.45 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3B (29 genes, +0.45);5F (+0.00) 5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 TRIM50 NM_178125 3 72726531 72742085 15507 1464 100 no 7 txStart-exon7 5'UTR-3'UTR 928 3' 72726578 72742085 dbVar chr7:72708999-74058000;chr7:72719000-72789000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 55.55 0.317380023327075 0.681275321847818 135892 7 1.5479e-10 2.7256e-06 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 FKBP6 NM_003602 5 72742163 72772634 30471 984 100 no 9 txStart-txEnd 5'UTR-3'UTR 72742163 72772634 Spermatogenic failure 77, 620103 (3) AR morbid:FKBP6 7:72742164-72772634 1 Male_infertility;Spermatogenic_failure_77 dbVar chr7:72708999-74058000;chr7:72719000-72789000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 65.69 1.49986407027643 1.4396607305099 spermatogenic failure 77 AR Moderate 8468 604839 Spermatogenic failure 77, 620103 (3) AR AR yes 5 1.3955e-06 1.3060e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 FZD9 NM_003508 3 72848107 72850450 2343 1776 84 no 1 txStart-txEnd 5'UTR-3'UTR 72848107 72850450 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 46.95 0.247827425263201 -1.18776035129969 -0.895389454591556 8326 4 1.9309e-03 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 BAZ1B NM_001370402 1 72854735 72936623 81888 4452 100 no 19 txStart-txEnd 5'UTR-3'UTR 72854735 72936623 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 529378 loss 23.74 1.02239565516008 0.0159631069818757 0.395552906953086 -0.902054979760057 4.05717005254254 autism spectrum disorder AD Limited 9031 0 1.0000e+00 1.0000e+00 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 BCL7B NM_001301061 2 72950685 72972020 21335 642 100 no 7 txStart-txEnd 5'UTR-3'UTR 72950685 72972020 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 28.63 1.05583278690403 -0.553040364632404 -0.0819162539430506 -0.44503506022657 1.74981493260157 9275 3 1.8519e-01 7.0664e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 TBL2 NM_012453 4 72981866 72992909 11043 1344 100 no 7 txStart-txEnd 5'UTR-3'UTR 72981866 72992909 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 30.81 -0.199291215312469 -0.922199212243606 -0.751016280020485 0.200201742907301 0.554223709974506 26608 4 1.8452e-04 4.3765e-03 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MLXIPL NM_032951 3 73007531 73038852 31321 2559 100 no 17 txStart-txEnd 5'UTR-3'UTR 73007531 73038852 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 730221;733450;733479;776773 loss 36.45 0.942636989769333 -0.774220086661663 -0.327638361779731 0.58127606528246 1.2288879277127 51085 2 4.7771e-02 6.7682e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 VPS37D NM_001077621 2 73082160 73086440 4280 756 100 no 4 txStart-txEnd 5'UTR-3'UTR 73082160 73086440 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 64.11 -0.0288746954043306 0.953055172354045 155382 1 9.1622e-01 6.5635e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 DNAJC30 NM_032317 3 73095247 73097783 2536 681 95 no 1 txStart-txEnd 5'UTR-3'UTR 73095247 73097783 Leber-like hereditary optic neuropathy, AR 1, 619382 (3) AR morbid:DNAJC30 7:73095248-73097783 1 DNAJC30-associated_disorder;Leber_hereditary_optic_neuropathy,_autosomal_recessive;Leber_optic_atrophy,_susceptibility_to dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 80.16 0.717396479665947 -0.500797326082256 -0.15204008716984 1.08623431117684 1.71697083676563 Leber hereditary optic neuropathy;Leber hereditary optic neuropathy, autosomal recessive AR;MT Limited;Strong;Supportive 33465056;33465056[PMID] 84277 618202 Leber-like hereditary optic neuropathy, AR 1, 619382 (3) AR AR yes 7 2.3092e-02 4.7983e-03 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 BUD23 NM_001202560 3 73097926 73112542 14616 897 100 no 13 txStart-txEnd 5'UTR-3'UTR 73097926 73112542 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 114049 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 STX1A NM_004603 4 73113539 73133999 20460 867 100 no 10 txStart-txEnd 5'UTR-3'UTR 73113539 73133999 1 Autism;Intellectual_disability dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 22.82 0.950800964625408 -0.794674734358171 -0.324619004824717 1.10438995088098 3.33806479625907 6804 1 9.7850e-01 9.1048e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MIR4284 NR_036247 1 73125646 73125727 81 0 0 no 1 txStart-txEnd UTR 73125646 73125727 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 100422948 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 ABHD11-AS1 NR_026690 1 73149398 73150330 932 0 0 no 4 txStart-txEnd UTR 73149398 73150330 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 171022 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 ABHD11 NM_148912 4 73150423 73153132 2709 921 100 no 6 txStart-txEnd 5'UTR-3'UTR 73150423 73153132 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 76.55 0.643446275430498 -0.675433866559718 -0.327510119466819 1.09331776236833 0.473373375061211 83451 5 2.9581e-03 9.0329e-06 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 CLDN3 NM_001306 4 73183326 73184600 1274 663 75 no 1 txStart-txEnd 5'UTR-3'UTR 73183326 73184600 dbVar chr7:72708999-74058000 0.01 dbVar chr7:73157999-73206000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 33.46 0.332553044404404 -0.966715148489597 -0.688425296234703 2.70903614483931 1.92914089110849 1365 4 5.2233e-01 6.7854e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 CLDN4 NM_001305 5 73245325 73247020 1695 630 42 no 1 txStart-txEnd 5'UTR-3'UTR 73245325 73247020 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 23.72 0.563064431580096 -0.809178554455325 -0.46244511082827 -0.0167724140747313 0.933080799622852 1364 9 6.9789e-05 1.3716e-04 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 METTL27 NM_152559 3 73248919 73256846 7927 738 100 no 6 txStart-txEnd 5'UTR-3'UTR 73248919 73256846 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 776775 loss 155368 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 TMEM270 NM_182504 4 73275488 73280220 4732 798 100 no 3 txStart-txEnd 5'UTR-3'UTR 73275488 73280220 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 135886 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 ELN NM_001278939 2 73442502 73484237 41735 2361 100 no 34 txStart-txEnd 5'UTR-3'UTR 73442502 73484237 Cutis laxa, AD, 123700 (3) AD;Supravalvar aortic stenosis, 185500 (3) AD dbVar:nssv15128578;dbVar:nssv15770120;dbVar:nssv16214480;dbVar:nssv16214500;dbVar:nssv17172746;dbVar:nssv17971140;dbVar:nssv18786274;dbVar:nssv18791884;dbVar:nssv18791887;morbid:ELN 7:73442503-73484237;7:73442509-73483040;7:73442519-73449764;7:73442519-73483030;7:73444331-73476493;7:73449675-73483050;7:73461986-73483030;7:73471703-73483040;7:73482968-73483050;7:73482988-73484237 101 Cutis_laxa,_autosomal_dominant_1;ELN-related_condition;Inborn_genetic_diseases;Supravalvar_aortic_stenosis;Williams_syndrome dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 3 0 8.62 0.1188507761401 -1.61408470478924 -1.04153334326364 -0.09395744769762 -0.0129976080826519 autosomal dominant cutis laxa;cutis laxa, autosomal dominant 1;supravalvular aortic stenosis AD Definitive;Strong;Supportive 10190324;10190538;10942104[PMID]_19844261[PMID];11175284;11735026;16085695[PMID]_18348261[PMID];18348261;19844261;21309044;23442826;27866049;28383366;31560829;8132745;8364568;8541862;9215670;9215671 2006 130160 Cutis laxa, AD, 123700 (3) AD;Supravalvar aortic stenosis, 185500 (3) AD AD yes 4 2.1429e-14 1.5200e-05 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 LIMK1 NM_002314 4 73498133 73536855 38722 1944 100 no 16 txStart-txEnd 5'UTR-3'UTR 73498133 73536855 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 596146;596546 loss 0 0 19.66 0.623604739936053 -0.79212126645541 -0.396805714672051 -0.48782967368913 2.85746490313868 3984 0 9.9937e-01 9.9090e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 EIF4H NM_022170 2 73588685 73611426 22741 747 100 no 7 txStart-txEnd 5'UTR-3'UTR 73588685 73611426 dbVar chr7:72708999-74058000 0.01 dbVar chr7:73504792-73813060 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 520421;520564;521476 loss;gain 21.78 0.339580839486745 -0.49261121282204 -0.247951312124761 -0.250271670703448 3.27930650064444 7458 2 4.3982e-01 9.2254e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MIR590 NR_030321 1 73605527 73605624 97 0 0 no 1 txStart-txEnd UTR 73605527 73605624 dbVar chr7:72708999-74058000 0.01 dbVar chr7:73504792-73813060 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 693175 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 LAT2 NM_014146 4 73624335 73644164 19829 732 100 no 13 txStart-txEnd 5'UTR-3'UTR 73624335 73644164 dbVar chr7:72708999-74058000 0.01 dbVar chr7:73504792-73813060 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 88.46 0.592710857132059 -0.653878691847743 -0.292110083865967 0.385787155434006 -0.303087706786894 7462 4 2.2295e-04 6.9106e-04 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 RFC2 NM_181471 3 73645831 73668729 22898 1065 100 no 11 txStart-txEnd 5'UTR-3'UTR 73645831 73668729 dbVar chr7:72708999-74058000 0.01 dbVar chr7:73504792-73813060 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 14.42 0.200864992787726 -0.430045328414053 -0.225638310792768 -0.430513909559958 1.53581142075512 5982 5 2.2054e-06 4.0421e-05 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 CLIP2 NM_003388 5 73703736 73820265 116529 3141 100 no 17 txStart-txEnd 5'UTR-3'UTR 73703736 73820265 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 730235;1376904;311922;312170 loss;gain 47.98 1.014608801418 -0.895566510532316 -0.401705936344982 -0.746648021563001 2.45305749434808 7461 0 9.9997e-01 9.9988e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 GTF2IRD1 NM_001199207 2 73868235 74016931 148696 2931 100 no 27 txStart-txEnd 5'UTR-3'UTR 73868235 74016931 dbVar chr7:72708999-74058000 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 287214;409861;257633;257740;257750;280118;596149;596444;598757;291764;291839;291840;730239 gain;loss 0 0 47.51 1.77201404347458 -0.0325005901648791 0.491444562429841 0.977775575032158 2.53365459317235 9569 1 9.0039e-01 9.9643e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 MIR10525 NR_162116 1 74010294 74010353 59 0 0 no 1 txStart-txEnd UTR 74010294 74010353 dbVar chr7:72708999-74058000;chr7:74008364-74140675 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 113218504 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 GTF2I NM_032999 4 74072043 74175022 67347 943 31 yes 35 txStart-intron12 5'UTR-CDS 3733 3' 74072043 74139390 dbVar chr7:74008364-74140675 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 529379;525619;534294;538338;776782;778027;776783;777959;777979;777991 loss;gain 0 0 33.5 0.964550444182401 4.23220859072885 2969 1 9.9592e-01 9.9935e-01 full=5 +7_72726579_74139390_DEL_1 7 72726579 74139390 -1412811 DEL Williams syndrom Pathogenic NA split q11.23 GTF2I-AS1 NR_110044 1 74103270 74143256 36120 0 0 no 4 intron2-txEnd UTR 2349 5' 74103270 74139390 dbVar chr7:74008364-74140675 0.01 IMH 7:66631329-143298938;7:67635774-98083201 0.5000 776783;777959;777979;777991 loss 101926943 full=5 +1_196756232_196799302_DEL_1 1 196756232 196799302 -43070 DEL Benign NA full q31.3 CFHR3;CFHR1 CFH CFHR4 2 ASPM (morbid/RE=EA_enhancer);CFH (morbid/RE=GH_promoter_enhancer) dbVar:nssv15121100 1:196757279-196796716 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv18330594;dbVar:nssv15777262;dbVar:nssv15169967;dbVar:nssv15146388;dbVar:nssv15151024 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:181453461-213107248;1:182388774-249111240;1:185644664-221698833;1:187113114-224487119;1:195483440-249213000 0.02;0.02;0.02;0.04;0.14;0.06;0.12;0.12;0.08 dbVar:nssv15129680;dbVar:nssv16207750;dbVar:nssv15146573;dbVar:nssv15151287;dbVar:nssv17970297;dbVar:nssv17970308;dbVar:nssv15146667;dbVar:nssv18329566;dbVar:nssv18330283;dbVar:nssv15154062;dbVar:nssv15134156;dbVar:nssv18792867;dbVar:nssv15146075;dbVar:nssv15119768 1:146053395-249233096;1:177551194-199599056;1:179002041-199694025;1:179011315-199022759;1:179073387-200192265;1:179413480-201764737;1:189003615-199584994;1:189633886-199854163;1:193011754-199882947;1:195089819-197443021;1:195483440-197865624;1:196676029-196842326;1:196712877-196797546;1:196722207-196808505 0.04;0.20;0.21;0.22;0.20;0.19;0.41;0.42;0.63;1.83;1.81;25.90;48.80;49.91 DDD:3693;dbVar chr1:196711121-196824857;chr1:196711121-196919131;chr1:196711478-197053461;1:196724161-196912840;chr1:196727600-196807000 0.1822 1000g;DDD:3692;DDD:3693;DDD:3695;dbVar;dgv11e55;dgv6e203;dgv87e199;esv2421560;esv3588469;nsv514031;nsv517662 1:196711068-196937536;1:196719268-196810043;1:196722346-196822692;1:196723048-196815791;1:196724161-196912840;1:196727851-196939719;chr1:196728877-196808865;1:196728878-196808865;1:196728878-196808865;1:196731149-196901753;1:196733402-196813850;1:196738898-196801697 0.4486 IMH 1:17124869-234920285;1:108097960-232960701 0.3095 chr1:196711121-196919131 dbVar;1:196724161-196912840 DDD:3693;chr1:196735895-196764940 dbVar;1:196761371-196761371 1000g;1:196779204-196779204 1000g;1:196792551-196801251 DDD:3714 chr1:196711121-196824857 dbVar;chr1:196711478-197053461 dbVar;chr1:196727600-196807000 dbVar;1:196748312-196757828 DDD:3701;chr1:196773811-196773879 dbVar;1:196780929-196780929 1000g 1:196719268-196810043 DDD:3692;1:196723048-196815791 esv2421560;1:196727851-196939719 dgv6e203;1:196728878-196808865 1000g;chr1:196729000-196789200 dbVar;1:196731149-196901753 dgv11e55;chr1:196735895-196764940 dbVar;1:196735896-196764940 esv3588471;1:196738898-196801697 nsv514031;chr1:196761000-196783900 dbVar;1:196772366-196774588 1000g;1:196772602-196794300 DDD:3705;1:196777327-196902217 DDD:3707;1:196782000-196788000 gnomAD-SV_v2.1_DEL_1_10685;1:196782356-196903873 1000g;1:196785120-196821192 DDD:3712;1:196790200-196805500 gnomAD-SV_v2.1_DEL_1_10686; 1:196711068-196937536 nsv517662;1:196722346-196822692 dgv87e199;1:196724161-196912840 DDD:3693;chr1:196728877-196808865 dbVar;1:196728878-196808865 esv3588469;1:196729000-196789200 gnomAD-SV_v2.1_DEL_1_10680;1:196733402-196813850 DDD:3695;1:196735896-196764940 1000g;1:196738624-196771280 DDD:3698;1:196748312-196757828 DDD:3701;chr1:196772365-196774588 dbVar;1:196772366-196774588 esv3588475;1:196773003-196909196 DDD:3706;chr1:196782000-196788000 dbVar;chr1:196782355-196903873 dbVar;1:196782356-196903873 esv3588478;chr1:196790200-196805500 dbVar;1:196798566-196802072 DDD:3720 1057190;1065487;2085508;1061944 gain 0.350 0.285 1:196797933-196799242 L1MDa 1:196756102-196796319 1:196796320-196825045 98.26 1.07662990621103 1.30887789301822 605336;134371 yes 8 2.6297e-08 9.0932e-04 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (2 genes, +0.00);5F (+0.00) 5 +1_196756232_196799302_DEL_1 1 196756232 196799302 -43070 DEL Benign NA split q31.3 CFHR3 NM_021023 6 196743969 196764537 8306 563 56 yes 6 intron3-txEnd CDS-3'UTR 1114 3' 196756231 196764537 DDD:3693;dbVar chr1:196711121-196824857;chr1:196711121-196919131;chr1:196711478-197053461;1:196724161-196912840;chr1:196727600-196807000;chr1:196735895-196764940 0.1822 1000g;DDD:3692;DDD:3693;DDD:3695;DDD:3698;dbVar;dgv11e55;dgv6e203;dgv87e199;esv2421560;esv3588469;esv3588471;gnomAD-SV_v2.1_DEL_1_10680;nsv514031;nsv517662 1:196711068-196937536;1:196719268-196810043;1:196722346-196822692;1:196723048-196815791;1:196724161-196912840;1:196727851-196939719;chr1:196728877-196808865;1:196728878-196808865;1:196728878-196808865;chr1:196729000-196789200;1:196729000-196789200;1:196731149-196901753;1:196733402-196813850;chr1:196735895-196764940;1:196735896-196764940;1:196735896-196764940;1:196738624-196771280;1:196738898-196801697 0.4486 IMH 1:17124869-234920285;1:108097960-232960701 0.3095 98.26 0.6684477327677 0.697024247535932 hemolytic uremic syndrome, atypical, susceptibility to, 1 Limited 22626820 10878 605336 (Hemolytic uremic syndrome, atypical, susceptibility to), 235400 (3) AR,AD;(Macular degeneration, age-related, reduced risk of), 603075 (3) AD AD;AR,AD yes 8 1.7200e-11 1.2190e-05 full=5 +1_196756232_196799302_DEL_1 1 196756232 196799302 -43070 DEL Benign NA split q31.3 CFHR1 NM_002113 3 196788860 196801319 10442 607 61 yes 6 txStart-intron4 5'UTR-CDS 327 3' 196788860 196799302 DDD:3693;dbVar chr1:196711121-196824857;chr1:196711121-196919131;chr1:196711478-197053461;1:196724161-196912840;chr1:196727600-196807000 0.1822 1000g;DDD:3692;DDD:3693;DDD:3695;DDD:3706;DDD:3707;DDD:3712;dbVar;dgv11e55;dgv6e203;dgv87e199;esv2421560;esv3588469;esv3588478;nsv514031;nsv517662 1:196711068-196937536;1:196719268-196810043;1:196722346-196822692;1:196723048-196815791;1:196724161-196912840;1:196727851-196939719;chr1:196728877-196808865;1:196728878-196808865;1:196728878-196808865;1:196731149-196901753;1:196733402-196813850;1:196738898-196801697;1:196773003-196909196;1:196777327-196902217;chr1:196782355-196903873;1:196782356-196903873;1:196782356-196903873;1:196785120-196821192 0.4486 IMH 1:17124869-234920285;1:108097960-232960701 0.3095 1061944 gain 92.58 1.07662990621103 1.30887789301822 age related macular degeneration 1;dense deposit disease;hemolytic uremic syndrome, atypical, susceptibility to, 1 AD;AR Limited;Supportive 19745068;19861685;23728178[PMID];23830046 3078 134371 (Hemolytic uremic syndrome, atypical, susceptibility to), 235400 (3) AR,AD;(Macular degeneration, age-related, reduced risk of), 603075 (3) AD AD;AR,AD yes 8 2.6297e-08 9.0932e-04 full=5 +12_63935482_64130626_DEL_1 12 63935482 64130626 -195144 DEL DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA full q14.2 DPY19L2 AVPR1A RXYLT1 1 RXYLT1 (morbid/RE=GH_enhancer);TBK1 (morbid/RE=EA_enhancer) Spermatogenic failure 9, 613958 (3) AR dbVar:nssv15119764;dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63952694-64062354;12:63989747-63989817 dbVar:nssv15161620;dbVar:nssv15161414;nssv15161422;dbVar:nssv15171852;dbVar:nssv15161798;dbVar:nssv15171855 12:2-133851895;12:173788-133777902;12:191620-133777645;12:282466-133773393;12:621221-133779118 0.15;0.15;0.15;0.15;0.15 dbVar:nssv15136921 12:61300933-66961857 3.45 1 Spermatogenic_failure_9 IMH 12:11501488-96031049;12:40933234-113477160 0.1070 chr12:63936386-64131550 dbVar;chr12:63939158-64117235 dbVar;12:63939159-64117235 esv3629757;chr12:63944788-63947354 dbVar;chr12:63965589-63975135 dbVar;chr12:63988950-64000500 dbVar;chr12:64010193-64011854 dbVar;chr12:64011854-64015265 dbVar;12:64020291-64020367 DDD:38896;12:64069043-64136500 dgv280e214;chr12:64077066-64077827 dbVar;chr12:64078873-64107227 dbVar;chr12:64117634-64120295 dbVar;chr12:64129133-64134963 dbVar;chr12:63936386-64131550 dbVar;chr12:63939158-64117235 dbVar;12:63939159-64117235 esv3629757;chr12:63944788-63947354 dbVar;chr12:63965589-63975135 dbVar;chr12:63988950-64000500 dbVar;chr12:64010193-64011854 dbVar... chr12:63935000-63948000 dbVar;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888;chr12:63950451-64144961 dbVar;chr12:63965589-64010193 dbVar;chr12:63998600-64077000 dbVar;chr12:64010193-64015265 dbVar;chr12:64011854-64021530 dbVar;chr12:64061735-64073704 dbVar;chr12:64073704-64076066 dbVar;chr12:64078873-64079823 dbVar;chr12:64089900-64096000 dbVar;chr12:64125000-64130000 dbVar;chr12:63935000-63948000 dbVar;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888;chr12:63950451-64144961 dbVar;chr12:63965589-64010193 dbVar;chr12:63998600-64077000 dbVar... chr12:63936000-63986000 dbVar;chr12:63946269-64141505 dbVar;chr12:63946732-63946956 dbVar;12:63946733-63946956 IMH;chr12:63959839-63959910 dbVar;12:64020291-64020367 DDD:38896;chr12:64069257-64069348 dbVar;chr12:64076528-64076585 dbVar;chr12:64116494-64116881 dbVar;chr12:63923277-64119251 dbVar;chr12:63939158-64117235 dbVar;12:63946730-63946956 esv2662353;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265;chr12:63950172-63950241 dbVar;chr12:64015848-64018740 dbVar;chr12:64065000-64130000 dbVar;chr12:64069869-64069961 dbVar;chr12:64103835-64106468 dbVar;chr12:64122000-64127000 dbVar chr12:63923277-64119251 dbVar;chr12:63939158-64117235 dbVar;12:63946730-63946956 esv2662353;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265;chr12:63950172-63950241 dbVar;chr12:64015848-64018740 dbVar;chr12:64065000-64130000 dbVar;chr12:64069869-64069961 dbVar;chr12:64103835-64106468 dbVar;chr12:64122000-64127000 dbVar;chr12:63936000-63986000 dbVar;chr12:63946269-64141505 dbVar;chr12:63946732-63946956 dbVar;12:63946733-63946956 IMH;chr12:63959839-63959910 dbVar;12:64020291-64020367 DDD:38896;chr12:64069257-64069348 dbVar;chr12:64076528-64076585 dbVar;chr12:64116494-64116881 dbVar 350981;2692928;1491350;1087307;2792491;2353750;2965163;1209828;1619448;1883558;2814116;1194770;2089432;31158;2419380;119292;287527;981327;1267803;1760195;174035;1054499;1054500;693309;1328263;1881832;2850280 loss;gain 0.530 0.430 12:63935369-63935656 AluSq2 12:64130409-64130696 AluSq2 12:63923419-63951619 12:64119249-64146247 81.13 1.02618176351368 1.66555804568279 613893 yes 4 1.0936e-13 7.0294e-05 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (1 gene, +0.00);5F (+0.00) 5 +12_63935482_64130626_DEL_1 12 63935482 64130626 -195144 DEL DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA split q14.2 DPY19L2 NM_173812 5 63952692 64062273 109581 2277 100 no 22 txStart-txEnd 5'UTR-3'UTR 63952692 64062273 Spermatogenic failure 9, 613958 (3) AR dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63989747-63989817 1 Spermatogenic_failure_9 1000g;DDD:38888;dbVar;esv3629757;gnomAD-SV_v2.1_DUP_12_34997 chr12:63936386-64131550;12:63936386-64131550;chr12:63939158-64117235;12:63939159-64117235;12:63939159-64117235;12:63940549-64135811;chr12:63950451-64144961 0.0257 dbVar chr12:63923277-64119251;chr12:63939158-64117235;chr12:63946269-64141505 0.01 IMH 12:11501488-96031049;12:40933234-113477160 0.1070 1267803;1760195;1054499;1054500 loss;gain 81.13 1.02618176351368 1.66555804568279 male infertility due to globozoospermia;spermatogenic failure 9 AR Strong;Supportive 17008355;21397063;21397063[PMID]_22571172[PMID];21397064;22627659;22653751;25755131;25780569 283417 613893 Spermatogenic failure 9, 613958 (3) AR AR yes 4 1.0936e-13 7.0294e-05 full=5 +16_1565630_1571297_DUP_1 16 1565630 1571297 5667 DUP IFT140 tandem duplication Pathogenic NA full p13.3 IFT140 TELO2 TMEM204 1 dbVar:nssv17973053 16:1568198-1570829 dbVar:nssv16208781 16:1568218-1570809 Cranioectodermal_dysplasia|Saldino-Mainzer_syndrome|Joubert_syndrome_with_Jeune_asphyxiating_thoracic_dystrophy dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15147067;dbVar:nssv15148669;dbVar:nssv15147068;dbVar:nssv17649874;dbVar:nssv15152396;dbVar:nssv15150758;dbVar:nssv15149904;dbVar:nssv15154767;dbVar:nssv16254459;dbVar:nssv15149503;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv15147425;dbVar:nssv15147959;dbVar:nssv15147069;dbVar:nssv15148094;dbVar:nssv15147790;dbVar:nssv8639650;dbVar:nssv15606077;dbVar:nssv18326373;dbVar:nssv15146792;dbVar:nssv15147071;dbVar:nssv15145754;dbVar:nssv15155466;dbVar:nssv17955877;dbVar:nssv18841986;CLN:513805 16:61452-90294632;16:69194-90274381;16:73142-11390552;16:78802-9169448;16:79942-2610461;16:84486-5251013;16:85881-11209288;16:85881-19806921;16:85881-22442007;16:85881-3216551;16:85881-5249457;16:85881-9883129;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:93733-13420663;16:96767-11619372;16:96767-3264623;16:96767-4297186;16:97134-5122974;16:102840-28327676;16:109979-4316797;16:111044-6627459;16:716663-15836961;16:1271652-2283774;16:1328823-1969149;16:1505185-4415346;16:1561202-1573469;16:1565604-1571309;16:1565629-1571298 0.01;0.01;0.05;0.06;0.22;0.11;0.05;0.03;0.03;0.18;0.11;0.06;0.01;0.01;0.01;0.04;0.05;0.18;0.13;0.11;0.02;0.13;0.09;0.04;0.56;0.89;0.19;46.20;99.33;99.96 Retinitis pigmentosa 80, 617781 (3) AR;Short-rib thoracic dysplasia 9 with or without polydactyly, 266920 (3) AR dbVar:nssv15173022;dbVar:nssv15145815;dbVar:nssv15147164;dbVar:nssv15155465;dbVar:nssv15776300;dbVar:nssv15146945;dbVar:nssv15148829;dbVar:nssv15148018;dbVar:nssv15145816;dbVar:nssv18790909;nssv18790910;dbVar:nssv15771714;dbVar:nssv16214818;dbVar:nssv18792796;dbVar:nssv16214651;morbid:IFT140 16:61452-1593645;16:73142-1762524;16:73142-1823350;16:85881-1875694;16:85881-2053328;16:88166-1715454;16:96723-1917328;16:96767-1594015;16:96767-2047583;16:256303-1657267;16:624056-2115656;16:624056-2148005;16:811897-2130379;16:1203719-2185710;16:1560428-1662073 0.37;0.34;0.32;0.32;0.29;0.35;0.31;0.38;0.29;0.40;0.38;0.37;0.43;0.58;5.58 13 Jeune_thoracic_dystrophy;Retinal_dystrophy;Retinitis_pigmentosa;Retinitis_pigmentosa_80;Saldino-Mainzer_syndrome chr16:1527000-1569000 dbVar 0.520 0.500 16:1565418-1565697;16:1565698-1565893 AluJr;L1MEf 16:1571134-1571365 AluJb 69.24 -1.52736818830718 -0.448946429663129 -0.844654865976432 -0.922111894578121 -1.23259677674915 614620 yes 4 9.9140e-24 9.1377e-18 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_gain_source, +1.00);2I-3 (IFT140, +0.00);3A (1 gene, +0.00);5F (+0.00) 5 +16_1565630_1571297_DUP_1 16 1565630 1571297 5667 DUP IFT140 tandem duplication Pathogenic NA split p13.3 IFT140 NM_014714 4 1560427 1662073 5668 729 16 no 31 intron26-intron30 CDS 488 3' 1565629 1571297 dbVar:nssv17973053 16:1568198-1570829 dbVar:nssv16208781 16:1568218-1570809 13 Jeune_thoracic_dystrophy;Retinal_dystrophy;Retinitis_pigmentosa;Retinitis_pigmentosa_80;Saldino-Mainzer_syndrome 30 69.24 -1.52736818830718 -0.448946429663129 -0.844654865976432 -0.922111894578121 -1.23259677674915 IFT140-related recessive ciliopathy;Jeune syndrome;Leber congenital amaurosis;autosomal dominant polycystic kidney disease;retinitis pigmentosa;retinitis pigmentosa 80;short-rib thoracic dysplasia 9 with or without polydactyly AD;AR Definitive;Strong;Supportive 154653;22503633;22503633[PMID];22503633[PMID]_23418020[PMID]_24009529[PMID];23418020;24009529;26216056;26216056[PMID];26968735;30479745;31034313 9742 614620 Retinitis pigmentosa 80, 617781 (3) AR;Short-rib thoracic dysplasia 9 with or without polydactyly, 266920 (3) AR AR yes 4 9.9140e-24 9.1377e-18 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA full p12 COX10;CDRT15;HS3ST3B1;MGC12916;CDRT7;LOC101928475;CDRT8;PMP22;MIR4731;TEKT3;CDRT4;TVP23C-CDRT4;CDRT3;TVP23C COX10-DT FBXW10B 14 ABCG8 (morbid/RE=mTL_miRNA);ACBD5 (morbid/RE=mTL_miRNA);ACVRL1 (HI=3/morbid/RE=mTL_miRNA);AMH (morbid/RE=mTL_miRNA);ANKS6 (morbid/RE=mTL_miRNA);ATL3 (morbid/RE=mTL_miRNA);ATP9A (morbid/RE=mTL_miRNA);CABP4 (morbid/RE=mTL_miRNA);CACNA1C (morbid/RE=mTL_miRNA);CAVIN1 (morbid/RE=mTL_miRNA);CD4 (morbid/RE=mTL_miRNA);CDT1 (morbid/RE=mTL_miRNA);CEP104 (morbid/RE=mTL_miRNA);CHD7 (HI=3/morbid/RE=mTL_miRNA);CHEK1 (morbid/RE=mTL_miRNA);CHST6 (morbid/RE=mTL_miRNA);CISD2 (morbid/RE=mTL_miRNA);CPT1A (morbid/RE=mTL_miRNA);CREB1 (morbid/RE=mTL_miRNA);CRIPT (morbid/RE=mTL_miRNA);CYB5A (morbid/RE=mTL_miRNA);CYCS (morbid/RE=mTL_miRNA);DNAJB13 (morbid/RE=mTL_miRNA);DNAJB4 (morbid/RE=mTL_miRNA);DNAL1 (morbid/RE=mTL_miRNA);DPP9 (morbid/RE=mTL_miRNA);EIF2B2 (morbid/RE=mTL_miRNA);ELAC2 (morbid/RE=ABC_enhancer);EMC1 (morbid/RE=mTL_miRNA);FANCA (morbid/RE=mTL_miRNA);GAN (morbid/RE=mTL_miRNA);GATAD2B (HI=3/morbid/RE=mTL_miRNA);GNB5 (morbid/RE=mTL_miRNA);GOLGA2 (morbid/RE=mTL_miRNA);GPRC5B (morbid/RE=mTL_miRNA);HCFC1 (morbid/RE=mTL_miRNA);HCN4 (morbid/RE=mTL_miRNA);HFE (morbid/RE=mTL_miRNA);IKBKG (HI=3/morbid/RE=mTL_miRNA);IRAK4 (morbid/RE=mTL_miRNA);ISCA2 (morbid/RE=mTL_miRNA);KCND3 (morbid/RE=mTL_miRNA);KCNH2 (HI=3/morbid/RE=mTL_miRNA);KDM6B (morbid/RE=mTL_miRNA);KIAA1549 (morbid/RE=mTL_miRNA);LDHD (morbid/RE=mTL_miRNA);LIAS (morbid/RE=mTL_miRNA);LNPK (morbid/RE=mTL_miRNA);LRTOMT (morbid/RE=mTL_miRNA);LYN (morbid/RE=mTL_miRNA);MAP2K2 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MFSD2A (morbid/RE=mTL_miRNA);MVK (morbid/RE=mTL_miRNA);MYH9 (morbid/RE=mTL_miRNA);MYO1C (morbid/RE=mTL_miRNA);MYO6 (morbid/RE=mTL_miRNA);MYOCD (morbid/RE=ABC_enhancer);MYPN (morbid/RE=mTL_miRNA);NACC1 (morbid/RE=mTL_miRNA);NECTIN1 (morbid/RE=mTL_miRNA);NEK8 (morbid/RE=mTL_miRNA);NKAP (morbid/RE=mTL_miRNA);PAX3 (HI=3/morbid/RE=mTL_miRNA);PDE6D (morbid/RE=mTL_miRNA);PDHB (morbid/RE=mTL_miRNA);PEX6 (morbid/RE=mTL_miRNA);PIGL (morbid/RE=ABC_enhancer+GH_enhancer+GH_promoter_enhancer);PIGO (morbid/RE=mTL_miRNA);PLAA (morbid/RE=mTL_miRNA);PLPBP (morbid/RE=mTL_miRNA);POLR3A (morbid/RE=mTL_miRNA);PRIM1 (morbid/RE=mTL_miRNA);PTGIS (morbid/RE=mTL_miRNA);RMND1 (morbid/RE=mTL_miRNA);ROBO2 (morbid/RE=mTL_miRNA);RS1 (HI=3/morbid/RE=mTL_miRNA);RTN2 (morbid/RE=mTL_miRNA);SBF1 (morbid/RE=mTL_miRNA);SDHAF1 (morbid/RE=mTL_miRNA);SHOC2 (morbid/RE=mTL_miRNA);SIK1 (morbid/RE=mTL_miRNA);SLC12A6 (morbid/RE=mTL_miRNA);SLC1A4 (morbid/RE=mTL_miRNA);SLC25A15 (morbid/RE=mTL_miRNA);SLC27A4 (morbid/RE=mTL_miRNA);SLC30A2 (morbid/RE=mTL_miRNA);SOS1 (morbid/RE=mTL_miRNA);SPTA1 (morbid/RE=mTL_miRNA);SPTLC2 (morbid/RE=mTL_miRNA);SRSF1 (morbid/RE=mTL_miRNA);TAOK1 (HI=3/morbid/RE=mTL_miRNA);THRA (morbid/RE=mTL_miRNA);THSD4 (morbid/RE=mTL_miRNA);TIMM8A (HI=3/morbid/RE=mTL_miRNA);TLR7 (morbid/RE=mTL_miRNA);TMEM127 (HI=3/RE=mTL_miRNA);TMEM43 (morbid/RE=mTL_miRNA);TNRC6B (HI=3/morbid/RE=mTL_miRNA);TPM2 (morbid/RE=mTL_miRNA);TRIOBP (morbid/RE=mTL_miRNA);TTC19 (morbid/RE=ABC_enhancer+EA_enhancer);TTF2 (morbid/RE=mTL_miRNA);TUBB4A (morbid/RE=mTL_miRNA);VDR (morbid/RE=mTL_miRNA);VPS53 (morbid/RE=mTL_miRNA);WDR73 (morbid/RE=mTL_miRNA);ZSWIM7 (morbid/RE=ABC_enhancer+GH_enhancer) dbVar:nssv15123319;nssv18792872;dbVar:nssv15123460;dbVar:nssv15124534;dbVar:nssv15130870;dbVar:nssv15132574;nssv15139980;nssv16091758;dbVar:nssv15143888;dbVar:nssv15144711;dbVar:nssv15605910;dbVar:nssv15770494;dbVar:nssv15770609;dbVar:nssv15770794;dbVar:nssv16216948;dbVar:nssv17171394;dbVar:nssv17171395;dbVar:nssv17171396;dbVar:nssv17517518;dbVar:nssv17968761;dbVar:nssv17971796;dbVar:nssv18788963 17:14104013-15422557;17:14111773-15442066;17:14139890-15406546;17:14413313-15169915;17:15036413-15036413;17:15132095-15169674;17:15133085-15164054;17:15133095-15164078;17:15133097-15165152;17:15133098-15164054;17:15133961-15169915;17:15134215-15162530;17:15134215-15164064;17:15134229-15164050;17:15134234-15164044;17:15134235-15164044;17:15142769-15164064;17:15142779-15164054;17:15162412-15406546 ?Neuropathy, inflammatory demyelinating, 139393 (3) ?AD;Charcot-Marie-Tooth disease, type 1A, 118220 (3) AD;Charcot-Marie-Tooth disease, type 1E, 118300 (3) AD;Dejerine-Sottas disease, 145900 (3) AR,AD;Neuropathy, recurrent, with pressure palsies, 162500 (3) AD;Roussy-Levy syndrome, 180800 (3) AD;Spermatogenic failure 81, 620277 (3) AR HI3:PMP22;dbVar:nssv15119700;nssv15120161;dbVar:nssv15123358;dbVar:nssv15124100;dbVar:nssv15124536;dbVar:nssv15130148;nssv15131578;dbVar:nssv15131641;dbVar:nssv15132056;dbVar:nssv15133540;dbVar:nssv15152434;dbVar:nssv15605873;dbVar:nssv15770639;dbVar:nssv16212046;dbVar:nssv16213644;dbVar:nssv17171685;dbVar:nssv17171686;dbVar:nssv17171687;dbVar:nssv17517519;dbVar:nssv17968760;dbVar:nssv17971249;dbVar:nssv17971279;dbVar:nssv17972656;dbVar:nssv17974454;dbVar:nssv17974892;dbVar:nssv18788962;morbid:PMP22;morbid:TEKT3 17:14110044-14111913;17:14111773-15442066;17:14128551-15422557;17:14139890-15142928;17:14215740-15422582;17:14763747-15242181;17:15133085-15134407;17:15133085-15142938;17:15133085-15164054;17:15133095-15164078;17:15133095-15168690;17:15133098-15164054;17:15133961-15169915;17:15134215-15164064;17:15134234-15164044;17:15134235-15164044;17:15138536-15168643;17:15142769-15142948;17:15142779-15142938;17:15142779-15164054;17:15142930-15164044;17:15152792-15162532;17:15162392-15164044;17:15162402-15162520;17:15162402-15162523;17:15162402-15164054;17:15207129-15244914 17p12 recurrent (HNPP/CMT1A) region (includes PMP22) dbVar:nssv15148946;dbVar:nssv15150353;dbVar:nssv15149908;nssv15152170;dbVar:nssv15159024;dbVar:nssv15160732;dbVar:nssv15159027;dbVar:nssv15121114;dbVar:nssv17976715;dbVar:nssv15133502;dbVar:nssv15605908;dbVar:nssv17955950;dbVar:nssv18330199;dbVar:nssv15127850;dbVar:nssv15155527;dbVar:nssv18330563;dbVar:nssv16215327;dbVar:nssv15152221;dbVar:nssv15155528;dbVar:nssv15152212;dbVar:nssv15151828;dbVar:nssv15138362;dbVar:nssv18330766;dbVar:nssv15152433;dbVar:nssv15141972;dbVar:nssv15137438;dbVar:nssv15138198;dbVar:nssv15151261;dbVar:nssv15152245;dbVar:nssv15139258;nssv15130449;dbVar:nssv18329572;dbVar:nssv18330190;dbVar:nssv18330250;dbVar:nssv18329615;dbVar:nssv15133504;dbVar:nssv15138548;dbVar:nssv15133503;dbVar:nssv17976450;dbVar:nssv18842067;dbVar:nssv18792739;dbVar:nssv18792799;dbVar:nssv17955866;TS3:ISCA-37436;dbVar:nssv17649964;dbVar:nssv15123339;dbVar:nssv15141042;dbVar:nssv15122626;dbVar:nssv16867389;dbVar:nssv15140957;dbVar:nssv15141757;dbVar:nssv15123522;dbVar:nssv15159072;dbVar:nssv15605912;dbVar:nssv15137903;dbVar:nssv15123444;dbVar:nssv16207305;dbVar:nssv15136705;dbVar:nssv15134920;dbVar:nssv15132415;dbVar:nssv15133505 17:526-14667519;17:526-15027737;17:527-81041938;17:7215-81058310;17:8548-81060040;17:12345-81057996;17:10795577-17867596;17:11819315-17795978;17:14029614-15562901;17:14063252-15449627;17:14073285-15442296;17:14073564-15479923;17:14073604-15482773;17:14076431-15491532;17:14078284-15479940;17:14079631-15370444;17:14083055-15463054;17:14083055-15479940;17:14083055-15491532;17:14083055-15491533;17:14083055-15567669;17:14083056-15483608;17:14085653-15512120;17:14087934-15437330;17:14087934-15484358;17:14087934-15484858;17:14087934-15490100;17:14087934-15491532;17:14087934-15500645;17:14087935-15479940;17:14087935-15483608;17:14087935-15484358;17:14087935-15484630;17:14090301-15467184;17:14090301-15473590;17:14090301-15482240;17:14093319-15476314;17:14095257-15492591;17:14095307-15466762;17:14095307-15472344;17:14096090-15492591;17:14097916-15422952;17:14098197-15442500;17:14098278-15471179;17:14098661-15501133;17:14099743-15471179;17:14100119-15455297;17:14100119-15458649;17:14100119-15492400;17:14100119-15492444;17:14101030-15504740;17:14105875-15611546;17:14111773-15482872;17:14139858-15707850;17:14195643-15545880;17:15093601-15856310;17:15113718-18184130;17:15138003-20524013;17:15162482-20828612 3.87;6.17;1.66;1.66;1.66;1.66;18.98;22.45;87.52;96.80;98.02;95.42;95.23;94.83;95.74;98.41;97.24;96.07;95.28;95.28;90.39;95.82;94.07;99.10;96.10;96.06;95.71;95.61;94.99;96.40;96.15;96.10;96.08;97.46;97.01;96.41;97.03;96.04;97.85;97.45;96.09;99.83;99.82;97.75;95.68;97.85;99.02;98.78;96.38;96.38;95.54;88.74;97.02;83.05;92.31;45.69;10.69;5.65;4.93 17p12 recurrent (HNPP/CMT1A) region (includes PMP22);Mitochondrial complex IV deficiency, nuclear type 3, 619046 (3) AR morbid:COX10;dbVar:nssv15129689;dbVar:nssv17976967;dbVar:nssv18330114;dbVar:nssv15145216;dbVar:nssv18330761;dbVar:nssv15138335;dbVar:nssv18330252;dbVar:nssv15145035;dbVar:nssv15141682;dbVar:nssv15141099;dbVar:nssv15138794;dbVar:nssv18330872;dbVar:nssv15137498;nssv15155529;dbVar:nssv15137504;dbVar:nssv18330269;dbVar:nssv18842062;dbVar:nssv15141647;HI3:ISCA-37436;dbVar:nssv18330706;dbVar:nssv15150275;dbVar:nssv15129116;dbVar:nssv15123772;dbVar:nssv15141918;dbVar:nssv15159071;nssv15605909;dbVar:nssv15123331;dbVar:nssv15605911;dbVar:nssv18786371;dbVar:nssv15605913;dbVar:nssv16255829;dbVar:nssv15136096;dbVar:nssv15136245;dbVar:nssv15126994;dbVar:nssv15134560;dbVar:nssv15137984 17:13972821-14111994;17:14073604-15482773;17:14076990-15473312;17:14077820-15491532;17:14082226-15421861;17:14082946-15484858;17:14083055-15475087;17:14083056-15484859;17:14086859-15476561;17:14087788-15473312;17:14087788-15483608;17:14087788-15490100;17:14087789-15484858;17:14087934-15484858;17:14087934-15491532;17:14087935-15491532;17:14095257-15477547;17:14095640-15274712;17:14097916-15422952;17:14098248-15475654;17:14098661-15500645;17:14098787-15495266;17:14099743-15471179;17:14100119-15455238;17:14101030-15449627;17:14101030-15482817;17:14104013-15551814;17:14110128-15472344;17:14110452-15449097;17:14111755-15442178;17:14111773-15482872;17:14111773-15491748;17:14112032-15482773;17:14574436-15856310;17:14970117-17375771 8.53;95.23;96.11;94.92;98.66;95.72;96.40;95.73;96.56;96.85;96.14;95.70;96.05;96.06;95.61;95.61;97.08;99.62;99.83;97.43;95.72;96.10;97.85;99.03;99.44;97.05;92.42;97.78;99.47;99.99;97.02;96.40;97.03;67.68;19.62 52 Charcot-Marie-Tooth_disease;Charcot-Marie-Tooth_disease,_type_I;Charcot-Marie-Tooth_disease,_type_IA;Charcot-Marie-Tooth_disease_type_1E;Charcot-Marie-Tooth_disease_type_2E;Cytochrome-c_oxidase_deficiency_disease;Dejerine-Sottas_disease;Dejerine-Sottas_syndrome,_autosomal_dominant;Hereditary_liability_to_pressure_palsies;Inborn_genetic_diseases;Mitochondrial_complex_4_deficiency,_nuclear_type_3;Roussy-Lévy_syndrome dbVar chr17:14096997-15486650 0.01 dbVar chr17:14093499-15486000 0.01 chr17:14126839-14220873 dbVar;17:14175896-14175896 1000g;17:14191081-14198547 DDD:48802;chr17:14216314-14217439 dbVar;17:14224375-14483419 1000g;chr17:14241867-14248195 dbVar;chr17:14284612-14628667 dbVar;chr17:14300914-14367997 dbVar;chr17:14386097-14390355 dbVar;chr17:14447875-14456539 dbVar;17:14527655-14527655 1000g;17:14668590-15084842 1000g;chr17:14670267-14671370 dbVar;chr17:14767901-14773352 dbVar;chr17:15028960-15030846 dbVar;17:15106636-15106636 1000g;chr17:15133798-15197525 dbVar;chr17:15287341-15482010 dbVar;chr17:15332787-15332860 dbVar;17:15417589-15417589 1000g;... chr17:14096997-15486650 dbVar;chr17:14159542-14160385 dbVar;17:14191081-14191901 DDD:48801;chr17:14194000-14199000 dbVar;chr17:14224374-14483419 dbVar;17:14224375-14483419 esv3640026;chr17:14256910-14257055 dbVar;chr17:14298872-14298951 dbVar;chr17:14334186-14339815 dbVar;17:14417929-14417929 1000g;chr17:14489639-14632921 dbVar;chr17:14668589-15084842 dbVar;17:14668590-15084842 esv3640046;chr17:14685229-14700196 dbVar;17:14817895-14817895 1000g;17:15043041-15043041 1000g;chr17:15118923-15125291 dbVar;chr17:15151620-15151916 dbVar;chr17:15323152-15369177 dbVar;17:15350668-15350668 1000g;chr17:15439000-15444000 dbVar... chr17:14096682-14108514 dbVar;chr17:14126839-14220873 dbVar;chr17:14155625-14155942 dbVar;chr17:14189910-14191555 dbVar;17:14189911-14191555 DDD:48799;17:14189911-14191555 esv2665541;17:14189911-14191557 1000g;17:14189912-14191555 IMH;17:14191081-14191901 DDD:48801;chr17:14220258-14221199 dbVar;17:14240918-14242023 DDD:48803;17:14240923-14242032 1000g;17:14240941-14242023 IMH;chr17:14241867-14248195 dbVar;chr17:14269249-14271950 dbVar;chr17:14277792-14278679 dbVar;chr17:14300414-14308117 dbVar;chr17:14314642-14320048 dbVar;chr17:14315900-14328444 dbVar;17:14332272-14332576 gnomAD-SV_v2.1_DEL_17_158748;chr17:14356167-14356388 dbVar... chr17:14093499-15486000 dbVar;chr17:14105499-14108091 dbVar;chr17:14132469-14133456 dbVar;chr17:14186324-14196555 dbVar;chr17:14189910-14191557 dbVar;chr17:14189911-14191555 dbVar;17:14189911-14191555 gnomAD-SV_v2.1_DEL_17_158736;17:14189911-14191557 esv3640023;17:14190834-14191460 nsv574421;chr17:14210420-14210623 dbVar;chr17:14224374-14483419 dbVar;chr17:14240922-14242032 dbVar;17:14240923-14242032 esv3640027;chr17:14240941-14242023 dbVar;chr17:14256280-14258428 dbVar;chr17:14272755-14288592 dbVar;chr17:14284612-14628667 dbVar;chr17:14300914-14367997 dbVar;chr17:14314678-14320063 dbVar;chr17:14332272-14332576 dbVar;chr17:14353108-14353170 dbVar... 557088;527329;960663;960664;271780;2830900;301045;262086;573463;591221;586955;271781;581715;527330;468582;482431;573464;531792;306277;570216;937731;271782;162997;826587;816488;787511;784668;811329;831423;864749;823089;2560430;815034;813495;809567;835854;40950;162998;288724;470190;429012;345937;271783;304081;826588;59114;782435;984637;470191;429013;1070158;... loss;gain 0.505 0.420 17:15422954-15470900 3 96.58 -2.62354415217069 -0.276965016632095 -1.64032033771268 3.6772325764896 4.17517843763452 602125;601097;612683 yes yes 1 9.0958e-01 8.3315e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_gain_source, +1.00);2H-2 (PMP22/TEKT3, +0.00);2J (COX10, +0.00);2L (TVP23C/TVP23C-CDRT4, +0.00);3A (14 genes, +0.00);5F (+0.00) 5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 COX10 NM_001303 4 13972820 14111994 11876 404 30 yes 7 intron6-txEnd CDS-3'UTR 4580 5' 14100118 14111994 dbVar:nssv15124536 17:14110044-14111913 1 Cytochrome-c_oxidase_deficiency_disease;Mitochondrial_complex_4_deficiency,_nuclear_type_3 dbVar chr17:14096997-15486650 0.01 dbVar chr17:14093499-15486000 0.01 30 60.22 -2.62354415217069 -2.20885612270982 -2.47162789907313 0.16322796385632 0.511864222455301 Leigh syndrome;cytochrome-c oxidase deficiency disease;mitochondrial complex 4 deficiency, nuclear type 3 AR Definitive;Moderate;Strong;Supportive 10767350;10767350[PMID]_12928484[PMID]_15455402[PMID];12928484;15455402;16103131;22622581;24100867 1352 602125 Mitochondrial complex IV deficiency, nuclear type 3, 619046 (3) AR AR yes 3 8.4050e-02 6.4657e-01 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT15 NM_001007530 3 14138989 14140179 1190 567 100 no 3 txStart-txEnd 5'UTR-3'UTR 14138989 14140179 dbVar chr17:14096997-15486650;chr17:14126839-14220873 0.01 dbVar chr17:14093499-15486000;chr17:14126839-14220873 0.01 96.58 -2.62354415217069 -2.20416703243077 -2.47162789907313 1.67462394349301 1.73432863871862 146822 9 1.2820e-06 7.5064e-03 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 HS3ST3B1 NM_006041 3 14204397 14252721 48324 1173 100 no 2 txStart-txEnd 5'UTR-3'UTR 14204397 14252721 dbVar chr17:14096997-15486650 0.01 dbVar chr17:14093499-15486000 0.01 288724;470190;429012;271783;1070158 loss;gain 42.95 -2.62354415217069 -0.276965016632095 -1.64032033771268 3.6772325764896 4.17517843763452 9953 4 2.9349e-01 8.5455e-02 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 MGC12916 NR_026880 1 14207056 14209062 2006 0 0 no 1 txStart-txEnd UTR 14207056 14209062 dbVar chr17:14096997-15486650;chr17:14126839-14220873 0.01 dbVar chr17:14093499-15486000;chr17:14126839-14220873 0.01 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT7 NR_033371 1 14934291 14935274 983 0 0 no 3 txStart-txEnd UTR 14934291 14935274 1000g;dbVar;esv3640046 chr17:14096997-15486650;chr17:14668589-15084842;17:14668590-15084842;17:14668590-15084842 0.2720 dbVar chr17:14093499-15486000;chr17:14668589-15084842;chr17:14920183-14938805;chr17:14931264-14977742 0.01 94150 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 LOC101928475 NR_135638 1 14954671 14955593 922 0 0 no 1 txStart-txEnd UTR 14954671 14955593 1000g;dbVar;esv3640046 chr17:14096997-15486650;chr17:14668589-15084842;17:14668590-15084842;17:14668590-15084842 0.2720 dbVar chr17:14093499-15486000;chr17:14668589-15084842;chr17:14931264-14977742 0.01 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT8 NR_103559 1 15008301 15009504 1203 0 0 no 2 txStart-txEnd UTR 15008301 15009504 1000g;dbVar;esv3640046 chr17:14096997-15486650;chr17:14668589-15084842;17:14668590-15084842;17:14668590-15084842 0.2720 dbVar chr17:14093499-15486000;chr17:14668589-15084842;chr17:14995672-15057656;chr17:14995771-15057475 0.01 94151 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 PMP22 NM_000304 4 15133095 15168643 35548 483 100 no 5 txStart-txEnd 5'UTR-3'UTR 15133095 15168643 dbVar:nssv15130870;dbVar:nssv15770494;dbVar:nssv15770609;dbVar:nssv15770794;dbVar:nssv17171395;dbVar:nssv17171396;dbVar:nssv17517518;dbVar:nssv17971796;dbVar:nssv18788963 17:15133097-15165152;17:15133098-15164054;17:15134215-15162530;17:15134215-15164064;17:15134229-15164050;17:15134234-15164044;17:15134235-15164044;17:15142769-15164064;17:15142779-15164054 ?Neuropathy, inflammatory demyelinating, 139393 (3) ?AD;Charcot-Marie-Tooth disease, type 1A, 118220 (3) AD;Charcot-Marie-Tooth disease, type 1E, 118300 (3) AD;Dejerine-Sottas disease, 145900 (3) AR,AD;Neuropathy, recurrent, with pressure palsies, 162500 (3) AD;Roussy-Levy syndrome, 180800 (3) AD dbVar:nssv15119700;nssv15120161;dbVar:nssv15131641;dbVar:nssv15133540;dbVar:nssv15770639;dbVar:nssv16212046;dbVar:nssv17171685;dbVar:nssv17171686;dbVar:nssv17171687;dbVar:nssv17517519;dbVar:nssv17968760;dbVar:nssv17971279;dbVar:nssv17974892;dbVar:nssv18788962;morbid:PMP22 17:15133098-15164054;17:15134215-15164064;17:15134234-15164044;17:15134235-15164044;17:15138536-15168643;17:15142769-15142948;17:15142779-15142938;17:15142779-15164054;17:15142930-15164044;17:15152792-15162532;17:15162392-15164044;17:15162402-15162520;17:15162402-15162523;17:15162402-15164054 51 Charcot-Marie-Tooth_disease;Charcot-Marie-Tooth_disease,_type_I;Charcot-Marie-Tooth_disease,_type_IA;Charcot-Marie-Tooth_disease_type_1E;Charcot-Marie-Tooth_disease_type_2E;Dejerine-Sottas_disease;Dejerine-Sottas_syndrome,_autosomal_dominant;Hereditary_liability_to_pressure_palsies;Inborn_genetic_diseases;Roussy-Lévy_syndrome dbVar chr17:14096997-15486650 0.01 dbVar chr17:14093499-15486000 0.01 740803;342512 loss;gain 3 0 40.48 -2.62354415217069 -1.55852578268999 -2.47162789907313 -0.424806725478425 1.07197498670855 Charcot-Marie-Tooth disease type 1A;Charcot-Marie-Tooth disease type 1E;Charcot-Marie-Tooth disease type 3;hereditary neuropathy with liability to pressure palsies AD Definitive;Moderate;Strong;Supportive 10330345;118220;12578939;162500;18698610[PMID]_12090401[PMID];20301384[PMID];23224996;24175617;601097;7931393;8355122;9143558;NULL 5376 601097 ?Neuropathy, inflammatory demyelinating, 139393 (3) ?AD;Charcot-Marie-Tooth disease, type 1A, 118220 (3) AD;Charcot-Marie-Tooth disease, type 1E, 118300 (3) AD;Dejerine-Sottas disease, 145900 (3) AR,AD;Neuropathy, recurrent, with pressure palsies, 162500 (3) AD;Roussy-Levy syndrome, 180800 (3) AD ?AD;AD;AR,AD yes yes 1 9.0958e-01 8.3315e-01 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 MIR4731 NR_039884 1 15154943 15155013 70 0 0 no 1 txStart-txEnd UTR 15154943 15155013 dbVar chr17:14096997-15486650;chr17:15133798-15197525 0.01 dbVar chr17:14093499-15486000;chr17:15070858-15163533;chr17:15112458-15159531;chr17:15150741-15155583 0.01 100616125 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 TEKT3 NM_031898 3 15207128 15244914 37786 1473 100 no 9 txStart-txEnd 5'UTR-3'UTR 15207128 15244914 Spermatogenic failure 81, 620277 (3) AR morbid:TEKT3 17:15207129-15244914 dbVar chr17:14096997-15486650 0.01 dbVar chr17:14093499-15486000 0.01 740806;740807;740808;54646;740809;740810 loss;gain 59.06 -2.62354415217069 -1.25885348060374 -2.47162789907313 0.241972873531725 -0.405588628410555 spermatogenic failure 81 Limited 18951373;36708031 64518 612683 Spermatogenic failure 81, 620277 (3) AR AR yes 7 1.9845e-17 3.1995e-14 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT4 NM_001204477 2 15339331 15370935 31604 459 100 no 4 txStart-txEnd 5'UTR-3'UTR 15339331 15370935 dbVar chr17:14096997-15486650;chr17:15287341-15482010 0.01 dbVar chr17:14093499-15486000;chr17:15287341-15482010 0.01 86.77 -2.62354415217069 -2.24141606178004 -2.47162789907313 -0.193191475026352 0.152950560142403 284040 9 9.5789e-02 2.4429e-01 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 TVP23C-CDRT4 NM_001204478 2 15339331 15466797 102735 33 6 no 7 intron5-txEnd CDS-3'UTR 7032 5' 15339331 15442066 dbVar chr17:14096997-15486650;chr17:15287341-15482010 0.01 dbVar chr17:14093499-15486000;chr17:15287341-15482010 0.01 323831;1950846;1878175;1562489;1993654;39252 loss;gain 52.33 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.433099426603836 0.962176598220999 100533496 7 8.7378e-07 2.3623e-03 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 CDRT3 NR_146601 1 15373624 15374150 526 0 0 no 1 txStart-txEnd UTR 15373624 15374150 dbVar chr17:14096997-15486650;chr17:15287341-15482010 0.01 dbVar chr17:14093499-15486000;chr17:15287341-15482010 0.01 94145 full=5 +17_14100119_15442066_DUP_1 17 14100119 15442066 1341947 DUP PMP22 (CMT1A) Pathogenic NA split p12 TVP23C NM_145301 3 15405577 15466797 36489 369 44 no 6 intron5-txEnd CDS-3'UTR 7032 5' 15405577 15442066 dbVar chr17:14096997-15486650;chr17:15287341-15482010 0.01 dbVar chr17:14093499-15486000;chr17:15287341-15482010 0.01 49.2 -2.62354415217069 -2.53125239294469 -2.47162789907313 0.622094281610252 0.322678575541803 201158 7 2.3189e-05 1.3674e-04 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA full p14.1-p14.2 LINC00698;SYNPR;SYNPR-AS1;SNTN;LOC100130345;C3orf49;THOC7;THOC7-AS1;ATXN7;SCAANT1;PSMD6-AS2;PSMD6;PRICKLE2-AS1;LINC00994;PRICKLE2;PRICKLE2-AS2;PRICKLE2-AS3;ADAMTS9;ADAMTS9-AS1;ADAMTS9-AS2 CADPS MAGI1 20 SLC25A26 (morbid/RE=ABC_enhancer) Spinocerebellar ataxia 7, 164500 (3) AD morbid:ATXN7 3:63953470-63989138 dbVar:nssv15162889;dbVar:nssv15164144;dbVar:nssv15149891;nssv15151839 3:60175-197948027;3:61496-197838262;3:61893-197851986 1.18;1.18;1.18 dbVar:nssv15146214;dbVar:nssv15774780;dbVar:nssv15148889;dbVar:nssv15147494;dbVar:nssv17956097;dbVar:nssv16207905;dbVar:nssv15150232;dbVar:nssv15146193;dbVar:nssv15120308 3:54079046-66046136;3:57076137-65716956;3:57174453-90309110;3:57416266-64870197;3:59332509-70686155;3:60449668-65561638;3:60526227-63742930;3:61956522-68514983;3:64746925-78459248 19.47;26.96;7.03;25.91;20.52;45.57;24.99;35.52;3.81 2 Progressive_myoclonic_epilepsy_type_5;See_cases IMH 3:1200531-154949082;3:38627146-149162150 0.3422 chr3:62941958-63077128 dbVar;chr3:62988224-63196657 dbVar;chr3:63104365-63108343 dbVar;chr3:63129917-63140073 dbVar;3:63209013-63209013 1000g;chr3:63280423-63280757 dbVar;chr3:63532617-63568092 dbVar;chr3:63579031-63579207 dbVar;chr3:63725720-63725786 dbVar;chr3:63795271-63828291 dbVar;chr3:63964168-63964321 dbVar;chr3:64361507-64373876 dbVar;chr3:64363467-64363549 dbVar;3:64399232-64399232 1000g;chr3:64533047-64535763 dbVar;chr3:64533160-64535613 dbVar;chr3:64592460-64635589 dbVar;3:64606110-64606110 1000g;chr3:64759754-64760269 dbVar;3:64986948-64986948 1000g;chr3:65038885-65066135 dbVar... chr3:62940751-63017993 dbVar;chr3:62959750-62999530 dbVar;chr3:63039190-63205089 dbVar;chr3:63120822-63143847 dbVar;chr3:63203000-63216000 dbVar;3:63224614-63225527 IMH;chr3:63448301-63448496 dbVar;3:63540966-63540966 1000g;chr3:63581882-63581978 dbVar;3:63725720-63725786 gnomAD-SV_v2.1_DUP_3_8770;chr3:63962000-63963377 dbVar;3:64218944-64218944 1000g;3:64363176-64363234 gnomAD-SV_v2.1_DUP_3_8775;chr3:64391248-64521443 dbVar;chr3:64433374-64557649 dbVar;3:64533160-64535613 IMH;3:64533160-64535613 gnomAD-SV_v2.1_DUP_3_8779;chr3:64595652-64609395 dbVar;3:64658686-64658756 gnomAD-SV_v2.1_DUP_3_8780;chr3:64917502-65281259 dbVar;chr3:64993929-65024280 dbVar... chr3:62952324-62973934 dbVar;chr3:62959476-62994696 dbVar;chr3:62959774-62994551 dbVar;chr3:62986070-62987837 dbVar;chr3:63006837-63007330 dbVar;chr3:63072271-63072321 dbVar;chr3:63103673-63107733 dbVar;3:63104370-63107212 1000g;chr3:63128000-63139500 dbVar;3:63134848-63135305 1000g;chr3:63134856-63135309 dbVar;chr3:63134857-63135309 dbVar;3:63134857-63135309 gnomAD-SV_v2.1_DEL_3_33028;chr3:63164118-63164190 dbVar;chr3:63182335-63190512 dbVar;chr3:63184629-63185275 dbVar;chr3:63256602-63256696 dbVar;chr3:63321371-63322219 dbVar;chr3:63347273-63347343 dbVar;chr3:63382056-63382224 dbVar;chr3:63390588-63391286 dbVar... chr3:62938181-62985344 dbVar;chr3:62959345-62994669 dbVar;chr3:62959750-62999530 dbVar;chr3:62986062-62987807 dbVar;chr3:62992485-62993266 dbVar;chr3:63059041-63059108 dbVar;chr3:63081900-63082834 dbVar;chr3:63104369-63107212 dbVar;chr3:63119026-63120115 dbVar;chr3:63134847-63135305 dbVar;3:63134848-63135305 esv3596388;3:63134857-63135309 DDD:10454;3:63134857-63135309 esv2677248;3:63134858-63135309 IMH;chr3:63166947-63171818 dbVar;chr3:63184317-63184367 dbVar;chr3:63244236-63244406 dbVar;chr3:63299578-63299744 dbVar;chr3:63343372-63344883 dbVar;chr3:63353029-63353568 dbVar;chr3:63382382-63386505 dbVar... 465399;861891;435915;276093;499230;986538;1068008;1068049;1068051;1068055;356121;356412;356417;356440;639875;785617;366447;787942;107667;1001471;1871505;568338;683747;1010057;937826;670729;666457;879190;960773;770202;799721;494776;1274408;1680861;2707998;839074;1254755;982217;1989019;2782754;41481;1945945;2326969;2323872;1156484;1438065;1890712;2250641;2341391;2512207;2709178;... gain;loss 0.355 0.430 3:62939271-62939427 MER5A1 3:65268746-65268796;3:65268797-65269299 LTR16B;L1MB2 68.54 0.730304227093642 1.22944963357105 1.15014257139245 0.85336181383742 2.61388539526619 607640 yes 0 9.9544e-01 9.8784e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (20 genes, +0.00);5F (+0.00) 5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 LINC00698 NR_027104 1 63088363 63110738 22375 0 0 no 7 txStart-txEnd UTR 63088363 63110738 dbVar chr3:62988224-63196657;chr3:63039190-63205089 0.01 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 285401 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 SYNPR NM_001130003 2 63263983 63602600 338617 858 100 no 6 txStart-txEnd 5'UTR-3'UTR 63263983 63602600 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 982217;1989019;2782754;1945945;2326969;2323872;1156484;1438065;1890712;2250641;2341391;2512207;2709178;1484968;2346921;2817418;2979580;934596;936035;956432;970192;971293;972264;982600;994662;957452;996530;972875;979916;986395;952848;1353672;1401634;1501941;1501972;1649298;1715877;1790646;2003582;2037291;2140637;2307330;2433140;2905849;3025958;2388906;2813936;1363891;1601924;1866248;2272884;... gain;loss 27.35 -0.433167561551584 -0.551647400212283 132204 4 4.1913e-03 1.7171e-01 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 SYNPR-AS1 NR_046677 1 63409271 63535727 126456 0 0 no 5 txStart-txEnd UTR 63409271 63535727 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 548375;494779;1048428;726165;327622;1048429;1048432;494780;830151;726166;3073085;770204;1167330;2744480;89973;90090;2255770;770205 loss;gain 100874016 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.2 SNTN NM_001348756 2 63638350 63650888 12538 534 100 no 5 txStart-txEnd 5'UTR-3'UTR 63638350 63650888 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 309180 loss 66.14 0.0947592166796515 -0.338299474644844 -0.173049359454575 -0.0258588646723899 -1.1196806141136 132203 9 1.0257e-04 2.7379e-03 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 LOC100130345 NR_171774 1 63727499 63799313 71814 0 0 no 9 txStart-txEnd UTR 63727499 63799313 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 C3orf49 NM_001355236 2 63804974 63834312 29338 879 100 no 7 txStart-txEnd 5'UTR-3'UTR 63804974 63834312 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 68.54 132200 7 4.0628e-08 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 THOC7 NM_025075 4 63819545 63849481 29936 615 100 no 8 txStart-txEnd 5'UTR-3'UTR 63819545 63849481 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 770220 loss 7.39 0.226822637024357 -2.4455441384945 -1.79937886551949 -0.696357556154856 1.21996216564798 80145 4 6.0818e-03 9.7832e-01 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 THOC7-AS1 NR_104326 1 63846320 63847495 1175 0 0 no 2 txStart-txEnd UTR 63846320 63847495 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 100874039 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ATXN7 NM_001177387 1 63884074 63989138 105064 2838 100 no 13 txStart-txEnd 5'UTR-3'UTR 63884074 63989138 Spinocerebellar ataxia 7, 164500 (3) AD morbid:ATXN7 3:63953470-63989138 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 418781;708951;1038179;708952;708953;708954;708955;447003;447603;107668;59834 loss;gain 17.72 0.730304227093642 0.636006512326363 0.862222958307612 0.85336181383742 0.386394557252369 autosomal dominant cerebellar ataxia type II;spinocerebellar ataxia type 7 AD Definitive;Moderate;Strong;Supportive 20301317[PMID];7477379;8908515;9288099 6314 607640 Spinocerebellar ataxia 7, 164500 (3) AD AD yes 1 9.5950e-01 9.2856e-01 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 SCAANT1 NR_148359 1 63897193 63897448 255 0 0 no 1 txStart-txEnd UTR 63897193 63897448 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 100861563 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PSMD6-AS2 NR_038286 1 63989697 63997919 8222 0 0 no 3 txStart-txEnd UTR 63989697 63997919 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 447005 loss 100507062 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PSMD6 NM_001271779 2 63996226 64009170 12944 1329 100 no 9 txStart-txEnd 5'UTR-3'UTR 63996226 64009170 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 8.63 0.167507008532066 0.979835184836382 0.835574002005388 -0.764855351937167 1.81088903222596 9861 0 9.9518e-01 9.6209e-01 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2-AS1 NR_045697 1 64053639 64088807 35168 0 0 no 3 txStart-txEnd UTR 64053639 64088807 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 309182;276099;448792 gain;loss 100652759 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 LINC00994 NR_033978 1 64064036 64073039 9003 0 0 no 4 txStart-txEnd UTR 64064036 64073039 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 100287879 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2 NM_001370528 1 64077911 64253849 175938 2535 100 no 8 txStart-txEnd 5'UTR-3'UTR 64077911 64253849 2 Progressive_myoclonic_epilepsy_type_5;See_cases IMH 3:1200531-154949082;3:38627146-149162150 0.3422 1788970;448792;518859;276100;518860;770227;770228;770229;1231659;483530;940486;1904984;1922947;2849960;483531;2321740;2731090;3074273;1243506;135466;135902;135909;276101;733817;770230;770231;2731929;276102;1751877;770232 gain;loss 19.72 0.557303960601498 1.22944963357105 1.15014257139245 0.337534415605819 2.61388539526619 complex neurodevelopmental disorder AD Limited 166336 1 9.9544e-01 9.8784e-01 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2-AS2 NR_046701 1 64089145 64092034 2889 0 0 no 4 txStart-txEnd UTR 64089145 64092034 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 100874242 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 PRICKLE2-AS3 NR_046702 1 64173219 64187237 14018 0 0 no 4 txStart-txEnd UTR 64173219 64187237 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 100874243 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ADAMTS9 NM_182920 2 64501329 64673676 172347 5808 100 no 40 txStart-txEnd 5'UTR-3'UTR 64501329 64673676 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 787948;276109;1042031;549355;2823064;1504208;2044109;2240649;1135553;1511158;2044804;2075783;2593226;2599590;2694024;2845215;944263;944306;969017;970694;970756;970760;984390;1799872;1067782;1068009;1932599;1967350;2001537;2005149;2203224;2308508;2691373;2792679;2969713;1072114;1915647;1042032;726177;2144978;301933;592200;366448;571129;276110;947661;947689;1042033 loss;gain 31.58 -1.39811826175974 -0.477054147176997 -0.711187689176027 -0.797615479905467 0.510431064472241 ciliopathy;nephronophthisis 1 AR Limited;Supportive 30609407[PMID] 56999 1 1.0004e-06 4.2266e-07 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ADAMTS9-AS1 NR_110150 1 64547021 64575760 28739 0 0 no 3 txStart-txEnd UTR 64547021 64575760 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 101929335 full=5 +3_62939218_65268743_DEL_1 3 62939218 65268743 -2329525 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split p14.1 ADAMTS9-AS2 NR_038264 1 64670545 64997143 326598 0 0 no 6 txStart-txEnd UTR 64670545 64997143 IMH 3:1200531-154949082;3:38627146-149162150 0.3422 787949 loss 100507098 full=5 +3_97483034_97487074_DEL_1 3 97483034 97487074 -4040 DEL BBS3/ARL6 promotor overlapped Pathogenic NA full q11.2 ARL6 EPHA6 CRYBG3 1 dbVar:nssv16214088 3:97486953-97487074 dbVar:nssv15162889;dbVar:nssv15164144;dbVar:nssv15149891;nssv15151839;dbVar:nssv17976063;dbVar:nssv15148953;dbVar:nssv15148997 3:60175-197948027;3:61496-197838262;3:61893-197851986;3:72488758-99614758;3:93519465-145413168;3:93538468-103607593 0.00;0.00;0.00;0.01;0.01;0.04 Bardet-Biedl syndrome 3, 600151 (3) AR;Retinitis pigmentosa 55, 613575 (3) AR;Bardet-Biedl syndrome 1, modifier of, 209900 (3) Digenic recessive,AR dbVar:nssv15147282;dbVar:nssv15146259;dbVar:nssv18842017;dbVar:nssv16254235;dbVar:nssv17171854;morbid:ARL6;dbVar:nssv18326626;dbVar:nssv17971170 3:93538468-116605903;3:93605516-122935530;3:93698392-124492857;3:95563097-102371126;3:97194197-97510809;3:97483602-97520073;3:97483823-97499002;3:97486953-97516893 0.02;0.01;0.01;0.06;1.28;9.52;21.42;0.41 4 Bardet-Biedl_syndrome_1;Bardet-Biedl_syndrome_3;Retinitis_pigmentosa;Retinitis_pigmentosa_55 dbVar chr3:97481287-97495551 0.01 IMH 3:1200531-154949082;3:38627146-149162150;3:75497389-125619977 0.3422 chr3:97481287-97495551 dbVar 0.455 0.335 10.16 0.309918017790144 -0.416168538751037 -0.151628993663861 -0.139439307213778 -0.254839803839483 608845 yes yes 5 1.0130e-02 4.2709e-03 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (1 gene, +0.00);5F (+0.00) 5 +3_97483034_97487074_DEL_1 3 97483034 97487074 -4040 DEL BBS3/ARL6 promotor overlapped Pathogenic NA split q11.2 ARL6 NM_032146 5 97483364 97520086 3710 123 21 no 9 txStart-intron3 5'UTR-CDS 0 5' 97483364 97487074 dbVar:nssv16214088 3:97486953-97487074 4 Bardet-Biedl_syndrome_1;Bardet-Biedl_syndrome_3;Retinitis_pigmentosa;Retinitis_pigmentosa_55 dbVar chr3:97481287-97495551 0.01 IMH 3:1200531-154949082;3:38627146-149162150;3:75497389-125619977 0.3422 30 0 10.16 0.309918017790144 -0.416168538751037 -0.151628993663861 -0.139439307213778 -0.254839803839483 Bardet-Biedl syndrome;Bardet-Biedl syndrome 3;retinitis pigmentosa;retinitis pigmentosa 55 AD;AR Definitive;Strong;Supportive 10973238;10973251;11381270;11567139;12016587;12118255;12524598;12567324;12837689;14520415;15137946;15258860;15314642;16308660;16380913;16582908;16606853;17160889;18203199;18327255;19858128;19956407;20142850;20301537[PMID];20301590[PMID];20333246;20618352;20671153;20805367;21282186;21937992;22085962;22334370;22353939;250666;26355662;26489029;27124789;27486776;28130426;28502102;31736247;7711739;7987310;8298649;9714014 84100 608845 Bardet-Biedl syndrome 3, 600151 (3) AR;Retinitis pigmentosa 55, 613575 (3) AR;(Bardet-Biedl syndrome 1, modifier of), 209900 (3) Digenic recessive,AR AR;Digenic recessive,AR yes yes 5 1.0130e-02 4.2709e-03 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA full q14.3 MIR3660;LINC01339;CETN3;LOC731157;MBLAC2;POLR3G;LYSMD3;ADGRV1;LUCAT1;ARRDC3;ARRDC3-AS1 MEF2C-AS1 NR2F1-AS1 11 AGO2 (morbid/RE=mTL_miRNA);B4GALNT1 (morbid/RE=mTL_miRNA);CEP57 (morbid/RE=mTL_miRNA);EPHA2 (morbid/RE=mTL_miRNA);GFPT1 (morbid/RE=mTL_miRNA);GPSM2 (morbid/RE=mTL_miRNA);KDM6A (HI=3/morbid/RE=mTL_miRNA);KMT2A (HI=3/morbid/RE=mTL_miRNA);MEF2C (HI=3/morbid/RE=ABC_enhancer+GH_enhancer);MSX2 (morbid/RE=mTL_miRNA);NODAL (morbid/RE=mTL_miRNA);NR2F1 (HI=3/morbid/RE=ABC_enhancer);PIGS (morbid/RE=mTL_miRNA);PLEKHM1 (morbid/RE=mTL_miRNA);PPP1R15B (morbid/RE=mTL_miRNA);PRKACB (morbid/RE=mTL_miRNA);SELENOI (morbid/RE=mTL_miRNA) dbVar:nssv17172150;dbVar:nssv17172151;dbVar:nssv17974002;dbVar:nssv17974003;dbVar:nssv17976802 5:89920928-89923613;5:89938434-89948400;5:89938454-89949769;5:90136804-90261231;5:90144435-90159694 ?Febrile seizures, familial, 4, 604352 (3) AD;Usher syndrome, type 2C, 605472 (3) Digenic dominant,AR;Usher syndrome, type 2C, GPR98;PDZD7 digenic, 605472 (3) Digenic dominant,AR;Usher_syndrome_type_2C CLN:2419348;dbVar:nssv15120153;dbVar:nssv15132320;dbVar:nssv15222969;dbVar:nssv15771046;dbVar:nssv15772847;nssv15776039;dbVar:nssv15774334;dbVar:nssv16211859;dbVar:nssv17171561;dbVar:nssv17955830;dbVar:nssv17955831;dbVar:nssv17970856;dbVar:nssv17971694;dbVar:nssv17972093;dbVar:nssv17972414;dbVar:nssv17974150;dbVar:nssv17975051;dbVar:nssv17976597;dbVar:nssv18787826;dbVar:nssv18787827;dbVar:nssv18787828;dbVar:nssv18787829;dbVar:nssv18787830;dbVar:nssv18787831;dbVar:nssv18787832;dbVar:nssv18787833;dbVar:nssv18787834;dbVar:nssv18792626;dbVar:nssv8639335;dbVar:nssv8639887;morbid:ADGRV1 5:89414155-89415062;5:89414156-89415061;5:89523964-90412409;5:89854614-90460254;5:89854714-90459717;5:89910547-90079868;5:89910633-90002231;5:89915000-89968362;5:89918395-90059306;5:89930912-90079894;5:89940238-89999954;5:89940504-89986878;5:89940571-89940765;5:89953703-89954115;5:89953723-89954095;5:89969852-89975466;5:89988605-90077246;5:89989688-90000325;5:89990520-90136394;5:89992735-90125023;5:89999463-89999632;5:90015866-90016040;5:90046349-90049666;5:90112103-90219415;5:90119223-90151738;5:90150020-90159573;5:90151539-90151738;5:90221275-90357290;5:90261233-90678909;5:90368245-90398177;5:90368250-90459732 CLN:1393621;CLN:1447486;dbVar:nssv17971430;dbVar:nssv17974885 5:89949103-89949102;5:89949103-89949236;5:89990260-89990259;5:89990260-89990371 dbVar:nssv15164761;dbVar:nssv15164765;dbVar:nssv15151111;nssv15151221;dbVar:nssv16206767;dbVar:nssv15120567;dbVar:nssv15132159;dbVar:nssv15142272;dbVar:nssv15151420;dbVar:nssv15135062;dbVar:nssv16207624;dbVar:nssv15776426 5:13649-180905029;5:25329-180693344;5:113578-180719789;5:72790062-97478870;5:73459012-110145153;5:86420656-92718726;5:86621338-89204392;5:87399002-92675748;5:87493550-92528869;5:87792845-109221844;5:89949119-129317455 1.67;1.68;1.68;12.26;8.25;48.08;16.65;57.39;60.14;14.13;4.71 dbVar:nssv15151179;dbVar:nssv17970035;dbVar:nssv15138006;dbVar:nssv15127576;dbVar:nssv15120741;dbVar:nssv15122759;dbVar:nssv15143209;nssv17976344;dbVar:nssv15133640;dbVar:nssv15140345;dbVar:nssv15132311;dbVar:nssv18841850;dbVar:nssv15167313;dbVar:nssv15121450;dbVar:nssv15142367;dbVar:nssv15132971;dbVar:nssv15133836;dbVar:nssv15121948;dbVar:nssv15132637;dbVar:nssv15121951;dbVar:nssv15138054;dbVar:nssv15120743;dbVar:nssv15139660;dbVar:nssv8639414;dbVar:nssv15138098;dbVar:nssv15152898 5:17628742-176575720;5:82185952-90110454;5:83899399-110770779;5:85045626-89302638;5:86039541-91633081;5:86062777-91444662;5:86400001-154000000;5:86487716-89253266;5:86530416-88893604;5:86672701-100860147;5:87485354-93120303;5:87512315-95096562;5:87664107-91698938;5:87764486-90147447;5:88016215-88783092;5:88062498-89028098;5:88232588-93437723;5:88348148-88783092;5:88377170-104022949;5:89670424-127412115;5:90682370-97701584;5:90707526-130655256;5:91064111-93896378;5:91327087-93283043;5:91504102-104858348 1.91;16.86;11.27;12.41;51.11;49.62;4.48;17.32;5.05;21.34;53.74;39.93;72.48;57.62;1.14;26.28;58.17;2.01;19.35;5.65;15.96;2.74;26.07;24.30;2.23 319 ADGRV1-Related_Disorders;ADGRV1-related_condition;Autosomal_recessive_sensorineural_hearing_loss;Ear_malformation;Febrile_seizures,_familial,_4;Hearing_impairment;Hearing_loss,_autosomal_recessive;Rare_genetic_deafness;Retinal_dystrophy;Usher_syndrome;Usher_syndrome_type_2;Usher_syndrome_type_2C IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 chr5:88908578-88917988 dbVar;chr5:88923056-88924318 dbVar;chr5:89235196-89235428 dbVar;5:89264627-89264683 gnomAD-SV_v2.1_DUP_5_15710;5:89378369-89378369 1000g;5:89450782-89450782 1000g;chr5:89531601-89531940 dbVar;chr5:89628452-89648641 dbVar;5:89671041-89671041 1000g;5:89788663-89788952 IMH;5:89860422-89860742 1000g;chr5:90104120-90104339 dbVar;5:90178738-90178738 1000g;chr5:90262584-90262832 dbVar;chr5:90289016-90289191 dbVar;chr5:90438449-90438606 dbVar;chr5:90610837-90613664 dbVar;chr5:90618087-90620700 dbVar;5:90819292-90819292 1000g;5:90866987-90867072 gnomAD-SV_v2.1_DUP_5_15730;chr5:90897800-90897875 dbVar... 5:88804381-88804381 1000g;chr5:88916144-88918908 dbVar;chr5:88933279-88933593 dbVar;chr5:89264627-89264683 dbVar;chr5:89359900-89373100 dbVar;chr5:89450461-89452777 dbVar;5:89450998-89450998 1000g;chr5:89572897-89573040 dbVar;chr5:89657266-89676019 dbVar;chr5:89701625-89701760 dbVar;5:89851863-89851863 1000g;5:89997835-89997835 1000g;chr5:90113593-90118383 dbVar;chr5:90250672-90250748 dbVar;chr5:90273278-90273491 dbVar;chr5:90383359-90394423 dbVar;chr5:90574109-90575794 dbVar;chr5:90611309-90627643 dbVar;chr5:90674000-90680000 dbVar;chr5:90866987-90867072 dbVar;chr5:90897077-90897172 dbVar... chr5:88806361-88806411 dbVar;chr5:88831687-88837255 dbVar;chr5:89003565-89004043 dbVar;chr5:89003715-89004039 dbVar;5:89003716-89004039 esv3605750;5:89003721-89004043 esv2657768;chr5:89029798-89029893 dbVar;chr5:89045213-89045498 dbVar;chr5:89047323-89047872 dbVar;chr5:89067203-89083487 dbVar;chr5:89101197-89101273 dbVar;chr5:89113277-89114892 dbVar;chr5:89131325-89131385 dbVar;chr5:89209000-89239000 dbVar;chr5:89257321-89262348 dbVar;chr5:89359000-89373000 dbVar;chr5:89388378-89389723 dbVar;chr5:89436013-89437273 dbVar;chr5:89563059-89564683 dbVar;chr5:89578750-89579142 dbVar;chr5:89710657-89712718 dbVar... chr5:88803653-88817310 dbVar;chr5:88824732-88824785 dbVar;chr5:88832512-88834519 dbVar;5:89003565-89004043 gnomAD-SV_v2.1_DEL_5_59965;5:89003716-89004039 1000g;5:89003721-89004043 IMH;chr5:89018000-89031000 dbVar;chr5:89039679-89039840 dbVar;chr5:89047322-89047872 dbVar;chr5:89052853-89052953 dbVar;chr5:89084915-89086582 dbVar;chr5:89112611-89115172 dbVar;chr5:89124435-89124505 dbVar;chr5:89171348-89171401 dbVar;chr5:89234368-89234446 dbVar;chr5:89299879-89302011 dbVar;chr5:89388306-89389753 dbVar;chr5:89407162-89407215 dbVar;chr5:89471562-89472013 dbVar;chr5:89574182-89585732 dbVar;chr5:89634867-89634964 dbVar... 1883320;592857;593588;593633;1328155;634829;634852;564142;727176;624588;1888140;2114074;940517;940575;674174;856984;857645;51544;620748;744569;430608;278131;1012046;241490;1048899;1049414;79894;80096;80110;80111;709899;343338;783070;808135;854054;116747;848199;830393;505759;187745;1896842;161012;433625;85336;644330;509507;540671;584871;870987;1042268;1048901;... loss;gain 0.335 0.275 5:91802185-91802338 L2a 38.97 0.855259196084686 1.02927857149332 1.26063232799998 1.13380694792028 1.83366808117122 602851 yes yes 1 9.8715e-01 9.7875e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (11 genes, +0.00);5F (+0.00) 5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 MIR3660 NR_037433 1 89312437 89312537 100 0 0 no 1 txStart-txEnd UTR 89312437 89312537 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 100500825 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LINC01339 NR_120601 1 89454155 89585888 131733 0 0 no 6 txStart-txEnd UTR 89454155 89585888 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 101929495 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 CETN3 NM_001297765 2 89688073 89705573 17500 576 100 no 6 txStart-txEnd 5'UTR-3'UTR 89688073 89705573 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 5.94 0.855259196084686 1.02927857149332 1.26063232799998 -1.0886019180172 0.322004765294048 1070 7 1.0528e-04 1.1321e-02 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LOC731157 NR_105024 1 89705816 89706486 670 0 0 no 2 txStart-txEnd UTR 89705816 89706486 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 MBLAC2 NM_203406 2 89754025 89770588 16563 840 100 no 2 txStart-txEnd 5'UTR-3'UTR 89754025 89770588 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 38.68 -0.0315707309390069 0.414676882744812 0.420940108293089 1.13380694792028 0.9911283716698 153364 7 4.5418e-05 2.8010e-04 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 POLR3G NM_001370354 1 89769745 89810374 40629 672 100 no 8 txStart-txEnd 5'UTR-3'UTR 89769745 89810374 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 38.97 0.478729015674934 0.798950378312061 0.929744998199481 0.494543657071353 -0.512733755306802 10622 8 1.7611e-10 6.4276e-05 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LYSMD3 NM_198273 2 89811442 89825401 13959 921 100 no 3 txStart-txEnd 5'UTR-3'UTR 89811442 89825401 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 28.58 0.0616099264393714 -0.398837217747125 116068 3 3.0382e-01 7.7182e-01 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 ADGRV1 NM_032119 4 89854613 90460254 605641 18921 100 no 90 txStart-txEnd 5'UTR-3'UTR 89854613 90460254 dbVar:nssv17172150;dbVar:nssv17172151;dbVar:nssv17974002;dbVar:nssv17974003;dbVar:nssv17976802 5:89920928-89923613;5:89938434-89948400;5:89938454-89949769;5:90136804-90261231;5:90144435-90159694 ?Febrile seizures, familial, 4, 604352 (3) AD;Usher syndrome, type 2C, 605472 (3) Digenic dominant,AR;Usher syndrome, type 2C, GPR98;PDZD7 digenic, 605472 (3) Digenic dominant,AR dbVar:nssv15120153;dbVar:nssv15222969;dbVar:nssv15771046;dbVar:nssv15772847;nssv15776039;dbVar:nssv15774334;dbVar:nssv17171561;dbVar:nssv17955830;dbVar:nssv17955831;dbVar:nssv17970856;dbVar:nssv17971694;dbVar:nssv17972093;dbVar:nssv17972414;dbVar:nssv17974150;dbVar:nssv17975051;dbVar:nssv17976597;dbVar:nssv18787826;dbVar:nssv18787827;dbVar:nssv18787828;dbVar:nssv18787829;dbVar:nssv18787830;dbVar:nssv18787831;dbVar:nssv18787832;dbVar:nssv18787833;dbVar:nssv18787834;dbVar:nssv8639335;dbVar:nssv8639887;morbid:ADGRV1 5:89854614-90460254;5:89854714-90459717;5:89910547-90079868;5:89910633-90002231;5:89915000-89968362;5:89918395-90059306;5:89930912-90079894;5:89940238-89999954;5:89940504-89986878;5:89940571-89940765;5:89953703-89954115;5:89953723-89954095;5:89969852-89975466;5:89988605-90077246;5:89989688-90000325;5:89990520-90136394;5:89992735-90125023;5:89999463-89999632;5:90015866-90016040;5:90046349-90049666;5:90112103-90219415;5:90119223-90151738;5:90150020-90159573;5:90151539-90151738;5:90221275-90357290;5:90368245-90398177;5:90368250-90459732 CLN:1393621;CLN:1447486;dbVar:nssv17971430;dbVar:nssv17974885 5:89949103-89949102;5:89949103-89949236;5:89990260-89990259;5:89990260-89990371 319 ADGRV1-Related_Disorders;ADGRV1-related_condition;Autosomal_recessive_sensorineural_hearing_loss;Ear_malformation;Febrile_seizures,_familial,_4;Hearing_impairment;Hearing_loss,_autosomal_recessive;Rare_genetic_deafness;Retinal_dystrophy;Usher_syndrome;Usher_syndrome_type_2;Usher_syndrome_type_2C IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 1048904;278132;1012047;709900;298920;299426;299474;1506541;808136;1048905;412573;792183;792683;213805;278133;744570;2587397;774121;868439;1167734;1235286;1667822;1048906;3092210;1030337;1030338;854055;332918;186491;1832039;344762;1129390;1453730;1591506;1919311;2227613;2411628;2991366;2533050;2100188;2294896;2857514;1919485;988869;1743351;1472404;2485541;1996536;2806466;2114593;1184520;... gain;loss 30 0 25.58 Usher syndrome type 2;Usher syndrome type 2C;febrile seizures, familial, 4;nonsyndromic genetic hearing loss AD;AR Definitive;Disputed Evidence;Limited;Strong;Supportive 14740321;16775142;19357116;19357117;20301515[PMID];22135276;22147658;23441107;25572244;280396 84059 602851 ?Febrile seizures, familial, 4, 604352 (3) AD;Usher syndrome, type 2C, 605472 (3) Digenic dominant,AR;Usher syndrome, type 2C, GPR98/PDZD7 digenic, 605472 (3) Digenic dominant,AR AD;Digenic dominant,AR yes yes full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 LUCAT1 NR_103548 1 90598802 90610219 11417 0 0 no 5 txStart-txEnd UTR 90598802 90610219 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 100505994 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 ARRDC3 NM_020801 4 90664447 90679134 14687 1245 100 no 8 txStart-txEnd 5'UTR-3'UTR 90664447 90679134 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 10.63 0.745040589608255 1.00834122048279 1.19108832249232 0.196967347879621 1.83366808117122 57561 1 9.8715e-01 9.7875e-01 full=5 +5_88774329_91802402_DEL_1 5 88774329 91802402 -3028073 DEL TAD MEF2C Pathogenic NA split q14.3 ARRDC3-AS1 NR_027435 1 90676163 90716532 40369 0 0 no 3 txStart-txEnd UTR 90676163 90716532 IMH 5:24758285-101693420;5:28691217-97582419;5:84488955-162334467 0.5483 100129716 full=5 +6_29854871_29896710_DEL_1 6 29854871 29896710 -41839 DEL Benign NA full p22.1 HLA-H;HCG4B HCP5B HLA-A 2 GABBR1 (morbid/RE=EA_enhancer);ZFP57 (morbid/RE=EA_enhancer+GH_enhancer+GH_promoter_enhancer) morbid:HLA-H 6:29855350-29858856 dbVar:nssv15166690;dbVar:nssv15166692;dbVar:nssv15161578;dbVar:nssv15161859;nssv15161868;dbVar:nssv15168255;dbVar:nssv15148873;dbVar:nssv15606075 6:60108-171054786;6:108667-170980171;6:156975-46757028;6:156976-170919482;6:165633-170919470;6:3224545-30624967;6:29455466-81447367 0.02;0.02;0.09;0.02;0.02;0.15;0.08 dbVar:nssv17955655 6:28005013-31683185 1.14 DDD:20149;IMH;dbVar 6:29698616-29950994;6:29722846-29947201;6:29723410-29948590;6:29733227-29961287;6:29760864-29916953;6:29762617-29919277;6:29767291-29923611;6:29767394-29923982;6:29771866-29927541;chr6:29833263-29905667;6:29840747-29917149 0.1073 1000g;DDD:20139;DDD:20142;DDD:20149;DDD:20154;IMH;dbVar;dgv1087e199;dgv7e195;esv2761013;esv2763941;esv3608493 6:29745199-29961072;6:29805446-29928380;6:29836637-29921127;6:29837073-29937311;6:29840747-29917149;6:29842746-29916111;6:29851122-29905999;chr6:29851172-29904515;6:29851173-29904515;6:29851173-29904515;6:29851444-29899493;6:29853315-29914786 0.4519 IMH 6:26743912-58149585;6:26745294-58149309 0.3871 6:29722846-29947201 IMH;6:29733227-29961287 IMH;6:29762617-29919277 IMH;6:29767394-29923982 IMH;6:29771866-29927541 IMH;6:29777143-29871794 IMH;chr6:29833263-29905667 dbVar;6:29892873-29892873 1000g 6:29698616-29950994 IMH;6:29723410-29948590 IMH;6:29760864-29916953 IMH;6:29767291-29923611 IMH;6:29769716-29865367 IMH;6:29773145-29867669 IMH;6:29778441-29873573 IMH;6:29840747-29917149 DDD:20149 6:29805446-29928380 DDD:20142;6:29836637-29921127 esv2763941;6:29840747-29917149 DDD:20149;6:29851122-29905999 IMH;6:29851173-29904515 1000g;6:29851444-29865718 esv2422126;6:29853315-29914786 DDD:20154;6:29861152-29916006 IMH;6:29864510-29936194 dgv1734e212;6:29890896-29906192 dgv1089e199;6:29892561-29905834 HI40:ISCA-46607 6:29745199-29961072 DDD:20139;6:29829109-29874629 dgv1726e212;6:29837073-29937311 esv2761013;6:29842746-29916111 dgv1087e199;chr6:29851172-29904515 dbVar;6:29851173-29904515 esv3608493;6:29851444-29899493 dgv7e195;6:29859518-29886164 dgv740n27;6:29864510-29889669 dgv1732e212;6:29873934-29890069 nsv515032;6:29891102-29906000 DDD:20157 0.375 0.510 6:29842025-29863148 yes 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (2 genes, +0.00);5F (+0.00) 5 +6_29854871_29896710_DEL_1 6 29854871 29896710 -41839 DEL Benign NA split p22.1 HLA-H NR_001434 4 29855349 29858856 3507 0 0 no 8 txStart-txEnd UTR 29855349 29858856 morbid:HLA-H 6:29855350-29858856 DDD:20149;IMH;dbVar 6:29698616-29950994;6:29722846-29947201;6:29723410-29948590;6:29733227-29961287;6:29760864-29916953;6:29762617-29919277;6:29767291-29923611;6:29767394-29923982;6:29769716-29865367;6:29771866-29927541;6:29773145-29867669;6:29777143-29871794;6:29778441-29873573;chr6:29833263-29905667;6:29840747-29917149 0.1073 1000g;DDD:20139;DDD:20142;DDD:20149;DDD:20154;IMH;dbVar;dgv1087e199;dgv1726e212;dgv7e195;esv2422126;esv2761013;esv2763941;esv3608493 6:29745199-29961072;6:29805446-29928380;6:29829109-29874629;6:29836637-29921127;6:29837073-29937311;6:29840747-29917149;6:29842746-29916111;6:29851122-29905999;chr6:29851172-29904515;6:29851173-29904515;6:29851173-29904515;6:29851444-29865718;6:29851444-29899493;6:29853315-29914786 0.4519 IMH 6:26743912-58149585;6:26745294-58149309 0.3871 3077 yes full=5 +6_29854871_29896710_DEL_1 6 29854871 29896710 -41839 DEL Benign NA split p22.1 HCG4B NR_001317 3 29892368 29894992 2624 0 0 no 1 txStart-txEnd UTR 29892368 29894992 DDD:20149;IMH;dbVar 6:29698616-29950994;6:29722846-29947201;6:29723410-29948590;6:29733227-29961287;6:29760864-29916953;6:29762617-29919277;6:29767291-29923611;6:29767394-29923982;6:29771866-29927541;chr6:29833263-29905667;6:29840747-29917149 0.1073 1000g;DDD:20139;DDD:20142;DDD:20149;DDD:20154;DDD:20157;IMH;dbVar;dgv1087e199;dgv1089e199;dgv1734e212;dgv7e195;esv2761013;esv2763941;esv3608493 6:29745199-29961072;6:29805446-29928380;6:29836637-29921127;6:29837073-29937311;6:29840747-29917149;6:29842746-29916111;6:29851122-29905999;chr6:29851172-29904515;6:29851173-29904515;6:29851173-29904515;6:29851444-29899493;6:29853315-29914786;6:29861152-29916006;6:29864510-29936194;6:29890896-29906192;6:29891102-29906000 0.4519 IMH 6:26743912-58149585;6:26745294-58149309 0.3871 80868 full=5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA full q12.1 RPS20;SNORD54;CERNA3;MOS;PLAG1;CHCHD7 SNORA1B SDR16C5 6 LYN (morbid/RE=ABC_enhancer+EA_enhancer+GH_enhancer+GH_promoter_enhancer) Adenomas, salivary gland pleomorphic, somatic, 181030 (3);Silver-Russell syndrome 4, 618907 (3) AD;Oocyte;zygote;embryo maturation arrest 20, 620383 (3) AR morbid:MOS;morbid:PLAG1 8:57025501-57026541;8:57073468-57123832 dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161801;nssv15777239;nssv17976962;dbVar:nssv15161417;nssv15161657;dbVar:nssv15161846;dbVar:nssv15169210;dbVar:nssv15161105;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161087;dbVar:nssv15161426;dbVar:nssv15161357;dbVar:nssv15777249;dbVar:nssv15147495;dbVar:nssv15774700;dbVar:nssv15161758;dbVar:nssv15161797;dbVar:nssv15139743;dbVar:nssv15135704 8:10214-146293414;8:13939-146304022;8:158049-146295771;8:158050-146295771;8:158992-146280828;8:164985-146293414;8:176453-146294098;8:191531-146274835;8:191531-146280020;8:191606-146280167;8:12491000-146295771;8:21149034-146295771;8:31936552-146295771;8:36437622-60531557;8:39555658-64049089;8:46942957-70216022;8:46942963-140297737;8:53436132-65195953;8:56228415-65864987 0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.13;0.14;0.15;0.16;0.76;0.75;0.79;0.20;1.56;1.90 dbVar:nssv15167540;dbVar:nssv15148967;dbVar:nssv15138741;dbVar:nssv15125104;dbVar:nssv15137960;dbVar:nssv15137390;dbVar:nssv15121489;dbVar:nssv15124419 8:49822484-58822602;8:50384338-58738029;8:54237950-62775577;8:54407102-58403572;8:55677511-57697858;8:55733918-62058861;8:56335974-59749312;8:56405321-57358911 2.04;2.20;2.15;4.59;9.09;2.90;5.38;19.25 8:57048633-57098412 1000g;chr8:57153249-57153357 dbVar;8:57161907-57161907 1000g chr8:57048632-57098412 dbVar;chr8:57048719-57098544 dbVar;chr8:57161314-57168512 dbVar chr8:56988070-56988448 dbVar;8:56988698-56989817 1000g;8:56988746-56989825 DDD:27790;chr8:56988762-56997935 dbVar;chr8:57005850-57007074 dbVar;chr8:57059737-57063078 dbVar;chr8:57160128-57168353 dbVar;chr8:57161314-57168512 dbVar chr8:56988017-57000275 dbVar;chr8:56988697-56989817 dbVar;chr8:56988709-56997905 dbVar;chr8:56988754-56989776 dbVar;8:56988763-56997935 1000g;chr8:57047231-57047490 dbVar;chr8:57154268-57155609 dbVar;chr8:57161113-57168156 dbVar 848459;394952;394953;395216;227414;227459;534473;534774;534866;302857;580548;575671;484667;558558;471349;469505;335198;335303;335354;376852;376955;376962;376972;376977;564747;681488;259626;589430;571930;312032;312165;312226;312239;302858;303092;303101;303169;303182;303196;303201;280931;777179;855820;280932;282047;282072 loss;gain 0.410 0.330 8:57169736-57169990 AluSz6 78.38 0.98432298330431 0.46663829854876 0.586548999968454 2.2343517715388 2.48184869967673 190060;603026 yes 0 9.9532e-01 8.2992e-01 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_loss_source, +1.00);3A (6 genes, +0.00);5F (+0.00) 5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 RPS20 NM_001146227 3 56979812 56987065 936 177 41 no 6 txStart-intron3 5'UTR-CDS 124 5' 56986129 56987065 29.1 0.98432298330431 -0.0464637247715686 0.36681079114905 -0.0133102053832282 2.09183372030708 Diamond-Blackfan anemia;familial colorectal cancer type X;hereditary nonpolyposis colon cancer AD Limited;Supportive 24941021[PMID];32790018[PMID] 6224 5 2.0686e-02 6.8632e-01 full=5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 SNORD54 NR_002437 1 56986397 56986460 63 0 0 no 1 txStart-txEnd UTR 56986397 56986460 26795 full=5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 CERNA3 NR_149110 1 56987150 56987833 683 0 0 no 2 txStart-txEnd UTR 56987150 56987833 105375847 full=5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 MOS NM_005372 1 57025500 57026541 1041 1041 100 no 1 txStart-txEnd 5'UTR-3'UTR 57025500 57026541 Oocyte;zygote;embryo maturation arrest 20, 620383 (3) AR morbid:MOS 8:57025501-57026541 78.38 0.159444434408663 0.46663829854876 0.524682444320288 2.2343517715388 2.48184869967673 oocyte/zygote/embryo maturation arrest 20 Limited 34779126;34997960;35670744 55034 190060 Oocyte/zygote/embryo maturation arrest 20, 620383 (3) AR AR yes 3 5.8928e-01 1.4931e-01 full=5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 PLAG1 NM_001114634 2 57073467 57123832 50365 1503 100 no 4 txStart-txEnd 5'UTR-3'UTR 57073467 57123832 Adenomas, salivary gland pleomorphic, somatic, 181030 (3);Silver-Russell syndrome 4, 618907 (3) AD morbid:PLAG1 8:57073468-57123832 280931;777179 gain 15.18 0.393657994766781 -2.53125239294469 -2.47162789907313 -0.349819812502603 1.96019845356841 silver-russell syndrome 4 AD Moderate;Strong 15606491;28796236;32546215 5324 603026 Adenomas, salivary gland pleomorphic, somatic, 181030 (3);Silver-Russell syndrome 4, 618907 (3) AD AD yes 0 9.9532e-01 8.2992e-01 full=5 +8_56986130_57169684_DEL_1 8 56986130 57169684 -183554 DEL VOUS in 2017, reclassified in 2020 Pathogenic NA split q12.1 CHCHD7 NM_001011668 3 57124347 57131368 7021 333 100 no 5 txStart-txEnd 5'UTR-3'UTR 57124347 57131368 47.62 0.447428062348521 0.400234098889925 0.586548999968454 -0.725400991144389 -0.857804306808559 79145 6 3.4885e-02 3.8798e-01 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA full p11.22 KDM5C;IQSEC2;SMC1A;MIR6857;RIBC1;HSD17B10;HUWE1;MIR98;MIRLET7F2 MIR6894 PHF8 9 ACACA (morbid/RE=mTL_miRNA);ACADM (morbid/RE=mTL_miRNA);ACTA1 (morbid/RE=mTL_miRNA);ACVR2B (morbid/RE=mTL_miRNA);ADA (morbid/RE=mTL_miRNA);ADGRE2 (morbid/RE=mTL_miRNA);ADGRG1 (morbid/RE=mTL_miRNA);ADH5 (morbid/RE=mTL_miRNA);AGO1 (morbid/RE=mTL_miRNA);AGPS (morbid/RE=mTL_miRNA);AK2 (morbid/RE=mTL_miRNA);ALAS2 (morbid/RE=ABC_enhancer);ALDH1A3 (morbid/RE=mTL_miRNA);ALDH7A1 (morbid/RE=mTL_miRNA);ALG3 (morbid/RE=mTL_miRNA);ALG8 (morbid/RE=mTL_miRNA);AMD1 (morbid/RE=mTL_miRNA);AMMECR1 (morbid/RE=mTL_miRNA);ANKRD11 (HI=3/morbid/RE=mTL_miRNA);ANTXR2 (morbid/RE=mTL_miRNA);AP1S1 (morbid/RE=mTL_miRNA);ARCN1 (HI=3/morbid/RE=mTL_miRNA);ARHGEF18 (morbid/RE=mTL_miRNA);ARID1A (HI=3/morbid/RE=mTL_miRNA);ARID1B (HI=3/morbid/RE=mTL_miRNA);ASCC3 (morbid/RE=mTL_miRNA);ATL1 (morbid/RE=mTL_miRNA);ATP13A3 (morbid/RE=mTL_miRNA);ATP2A2 (morbid/RE=mTL_miRNA);ATP7B (morbid/RE=mTL_miRNA);ATR (morbid/RE=mTL_miRNA);ATXN2 (morbid/RE=mTL_miRNA);B4GAT1 (morbid/RE=mTL_miRNA);BACH1 (morbid/RE=mTL_miRNA);BCL11A (HI=3/morbid/RE=mTL_miRNA);BCL2 (morbid/RE=mTL_miRNA);BCOR (HI=3/morbid/RE=mTL_miRNA);BNC2 (morbid/RE=mTL_miRNA);C12orf4 (morbid/RE=mTL_miRNA);C3 (morbid/RE=mTL_miRNA);CACNA1C (morbid/RE=mTL_miRNA);CACNB2 (morbid/RE=mTL_miRNA);CALM1 (morbid/RE=mTL_miRNA);CANT1 (morbid/RE=mTL_miRNA);CAPN15 (morbid/RE=mTL_miRNA);CBL (morbid/RE=mTL_miRNA);CCND2 (morbid/RE=mTL_miRNA);CCNF (morbid/RE=mTL_miRNA);CD59 (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CEP120 (morbid/RE=mTL_miRNA);CEP135 (morbid/RE=mTL_miRNA);CHD1 (morbid/RE=mTL_miRNA);CHD4 (morbid/RE=mTL_miRNA);CHD7 (HI=3/morbid/RE=mTL_miRNA);CHRNB1 (morbid/RE=mTL_miRNA);CHST3 (morbid/RE=mTL_miRNA);CKAP2L (morbid/RE=mTL_miRNA);CLP1 (morbid/RE=mTL_miRNA);CNKSR2 (HI=3/morbid/RE=mTL_miRNA);CNNM4 (morbid/RE=mTL_miRNA);COG5 (morbid/RE=mTL_miRNA);COLGALT1 (morbid/RE=mTL_miRNA);COPB2 (morbid/RE=mTL_miRNA);COX6B1 (morbid/RE=mTL_miRNA);CPOX (morbid/RE=mTL_miRNA);CREB1 (morbid/RE=mTL_miRNA);CRTAP (morbid/RE=mTL_miRNA);CRX (morbid/RE=mTL_miRNA);CTNND1 (morbid/RE=mTL_miRNA);CTPS1 (morbid/RE=mTL_miRNA);CTSC (morbid/RE=mTL_miRNA);CYB5R3 (morbid/RE=mTL_miRNA);CYP19A1 (morbid/RE=mTL_miRNA);DDR2 (morbid/RE=mTL_miRNA);DIABLO (morbid/RE=mTL_miRNA);DICER1 (HI=3/morbid/RE=mTL_miRNA);DNA2 (morbid/RE=mTL_miRNA);DNAAF2 (morbid/RE=mTL_miRNA);DNAH9 (morbid/RE=mTL_miRNA);DNAL1 (morbid/RE=mTL_miRNA);DOLK (morbid/RE=mTL_miRNA);DPAGT1 (morbid/RE=mTL_miRNA);DSG2 (morbid/RE=mTL_miRNA);DUSP6 (morbid/RE=mTL_miRNA);DVL3 (morbid/RE=mTL_miRNA);EDA (HI=3/morbid/RE=mTL_miRNA);EDEM3 (morbid/RE=mTL_miRNA);EDN1 (morbid/RE=mTL_miRNA);EIF2S3 (morbid/RE=mTL_miRNA);EIF4A2 (morbid/RE=mTL_miRNA);EIF4A3 (morbid/RE=mTL_miRNA);ELF4 (morbid/RE=mTL_miRNA);EZH2 (morbid/RE=mTL_miRNA);FADS3 (morbid/RE=mTL_miRNA);FAS (morbid/RE=mTL_miRNA);FBXL4 (morbid/RE=mTL_miRNA);FGD1 (HI=3/morbid/RE=ABC_enhancer+GH_promoter_enhancer);FKRP (morbid/RE=mTL_miRNA);FLAD1 (morbid/RE=mTL_miRNA);FOXC1 (HI=3/morbid/RE=mTL_miRNA);FXN (morbid/RE=mTL_miRNA);FZD4 (HI=3/morbid/RE=mTL_miRNA);GALC (morbid/RE=mTL_miRNA);GALNT2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GATM (morbid/RE=mTL_miRNA);GBF1 (morbid/RE=mTL_miRNA);GCNT2 (morbid/RE=mTL_miRNA);GDAP2 (morbid/RE=mTL_miRNA);GLMN (HI=3/morbid/RE=mTL_miRNA);GLUL (morbid/RE=mTL_miRNA);GNPTAB (morbid/RE=mTL_miRNA);HMGA2 (morbid/RE=mTL_miRNA);HNRNPDL (morbid/RE=mTL_miRNA);HNRNPU (morbid/RE=mTL_miRNA);HSPD1 (morbid/RE=mTL_miRNA);IFNAR1 (morbid/RE=mTL_miRNA);IFNGR1 (morbid/RE=mTL_miRNA);IGF1 (morbid/RE=mTL_miRNA);IGF1R (HI=3/morbid/RE=mTL_miRNA);IL21R (morbid/RE=mTL_miRNA);IL2RA (morbid/RE=mTL_miRNA);IL6R (morbid/RE=mTL_miRNA);IMPDH1 (morbid/RE=mTL_miRNA);IQCB1 (morbid/RE=mTL_miRNA);ITGA3 (morbid/RE=mTL_miRNA);ITGB3 (morbid/RE=mTL_miRNA);JAG1 (HI=3/morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNN3 (morbid/RE=mTL_miRNA);KLHL15 (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);KREMEN1 (morbid/RE=mTL_miRNA);LDLR (HI=3/morbid/RE=mTL_miRNA);LGR4 (morbid/RE=mTL_miRNA);LIFR (morbid/RE=mTL_miRNA);LMNB2 (morbid/RE=mTL_miRNA);LYN (morbid/RE=mTL_miRNA);MAGED2 (morbid/RE=ABC_enhancer);MAPK1 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MARS2 (morbid/RE=mTL_miRNA);MAX (HI=3/morbid/RE=mTL_miRNA);MCAT (morbid/RE=mTL_miRNA);MED13L (HI=3/morbid/RE=mTL_miRNA);MFSD8 (morbid/RE=mTL_miRNA);MIEF1 (morbid/RE=mTL_miRNA);MITF (HI=3/morbid/RE=mTL_miRNA);MMACHC (morbid/RE=mTL_miRNA);MPL (morbid/RE=mTL_miRNA);MRPS2 (morbid/RE=mTL_miRNA);MSH6 (HI=3/morbid/RE=mTL_miRNA);MSL3 (HI=3/morbid/RE=mTL_miRNA);MSMO1 (morbid/RE=mTL_miRNA);MYC (morbid/RE=mTL_miRNA);MYH9 (morbid/RE=mTL_miRNA);NAA15 (HI=3/morbid/RE=mTL_miRNA);NAA20 (morbid/RE=mTL_miRNA);NACC1 (morbid/RE=mTL_miRNA);NDUFAF3 (morbid/RE=mTL_miRNA);NFIB (morbid/RE=mTL_miRNA);NFKB2 (morbid/RE=mTL_miRNA);NHLRC2 (morbid/RE=mTL_miRNA);NKX2-1 (morbid/RE=mTL_miRNA);NPR3 (morbid/RE=mTL_miRNA);NR2F2 (morbid/RE=mTL_miRNA);NRAS (morbid/RE=mTL_miRNA);NSD1 (HI=3/morbid/RE=mTL_miRNA);OPA3 (morbid/RE=mTL_miRNA);OSMR (morbid/RE=mTL_miRNA);PAK1 (morbid/RE=mTL_miRNA);PCK1 (morbid/RE=mTL_miRNA);PDE4D (morbid/RE=mTL_miRNA);PDGFB (morbid/RE=mTL_miRNA);PDHB (morbid/RE=mTL_miRNA);PDSS1 (morbid/RE=mTL_miRNA);PDZD8 (morbid/RE=mTL_miRNA);PEX11B (morbid/RE=mTL_miRNA);PGK1 (morbid/RE=mTL_miRNA);PGM2L1 (morbid/RE=mTL_miRNA);PHF8 (HI=3/morbid/RE=ABC_enhancer+EA_enhancer+GH_enhancer+GH_promoter_enhancer+mTL_miRNA);PHKA1 (morbid/RE=mTL_miRNA);PICALM (morbid/RE=mTL_miRNA);PIGC (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);PLCG2 (morbid/RE=mTL_miRNA);PLOD2 (morbid/RE=mTL_miRNA);PLXND1 (morbid/RE=mTL_miRNA);PMPCA (morbid/RE=mTL_miRNA);POLR1D (HI=3/morbid/RE=mTL_miRNA);PPP1R15B (morbid/RE=mTL_miRNA);PTPN14 (morbid/RE=mTL_miRNA);PURA (HI=3/morbid/RE=mTL_miRNA);PUS1 (morbid/RE=mTL_miRNA);PXDN (morbid/RE=mTL_miRNA);PYCR1 (morbid/RE=mTL_miRNA);QDPR (morbid/RE=mTL_miRNA);RAB39B (HI=3/morbid/RE=mTL_miRNA);RAC1 (morbid/RE=mTL_miRNA);RB1CC1 (morbid/RE=mTL_miRNA);RDX (morbid/RE=mTL_miRNA);REL (morbid/RE=mTL_miRNA);RHBDF2 (morbid/RE=mTL_miRNA);RNF13 (morbid/RE=mTL_miRNA);ROR2 (morbid/RE=mTL_miRNA);RORA (morbid/RE=mTL_miRNA);RRM1 (morbid/RE=mTL_miRNA);RS1 (HI=3/morbid/RE=mTL_miRNA);SACS (morbid/RE=mTL_miRNA);SALL4 (HI=3/morbid/RE=mTL_miRNA);SAMD9L (morbid/RE=mTL_miRNA);SCD (morbid/RE=mTL_miRNA);SCUBE3 (morbid/RE=mTL_miRNA);SET (morbid/RE=mTL_miRNA);SHOC2 (morbid/RE=mTL_miRNA);SLC10A7 (morbid/RE=mTL_miRNA);SLC11A2 (morbid/RE=mTL_miRNA);SLC17A5 (morbid/RE=mTL_miRNA);SLC19A2 (morbid/RE=mTL_miRNA);SLC19A3 (morbid/RE=mTL_miRNA);SLC25A12 (morbid/RE=mTL_miRNA);SLC25A13 (morbid/RE=mTL_miRNA);SLC31A1 (morbid/RE=mTL_miRNA);SLC33A1 (morbid/RE=mTL_miRNA);SLC5A5 (morbid/RE=mTL_miRNA);SLC5A6 (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SMAD2 (morbid/RE=mTL_miRNA);SMARCA4 (morbid/RE=mTL_miRNA);SMARCAD1 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SOCS1 (morbid/RE=mTL_miRNA);SORD (morbid/RE=mTL_miRNA);SOX4 (morbid/RE=mTL_miRNA);SRCAP (morbid/RE=mTL_miRNA);STAT2 (morbid/RE=mTL_miRNA);STK4 (morbid/RE=mTL_miRNA);STS (HI=3/morbid/RE=mTL_miRNA);STX3 (morbid/RE=mTL_miRNA);SUOX (morbid/RE=mTL_miRNA);SYT1 (morbid/RE=mTL_miRNA);TAB2 (morbid/RE=mTL_miRNA);TBK1 (morbid/RE=mTL_miRNA);TCOF1 (HI=3/morbid/RE=mTL_miRNA);TEAD1 (morbid/RE=mTL_miRNA);TET3 (morbid/RE=mTL_miRNA);TFAP2A (morbid/RE=mTL_miRNA);TG (morbid/RE=mTL_miRNA);TGFBR1 (HI=3/morbid/RE=mTL_miRNA);TGFBR2 (morbid/RE=mTL_miRNA);TMEM147 (morbid/RE=mTL_miRNA);TMEM38B (morbid/RE=mTL_miRNA);TMTC3 (morbid/RE=mTL_miRNA);TNFRSF9 (morbid/RE=mTL_miRNA);TPP1 (morbid/RE=mTL_miRNA);TRAPPC10 (morbid/RE=mTL_miRNA);TRIM71 (morbid/RE=mTL_miRNA);TTI1 (morbid/RE=mTL_miRNA);TUBB2A (morbid/RE=mTL_miRNA);TUBB4A (morbid/RE=mTL_miRNA);TWIST1 (HI=3/morbid/RE=mTL_miRNA);TWNK (morbid/RE=mTL_miRNA);UBAP2L (morbid/RE=mTL_miRNA);VANGL1 (morbid/RE=mTL_miRNA);VCL (morbid/RE=mTL_miRNA);VPS33A (morbid/RE=mTL_miRNA);WARS2 (morbid/RE=mTL_miRNA);WBP11 (morbid/RE=mTL_miRNA);WDR73 (morbid/RE=mTL_miRNA);WNK1 (morbid/RE=mTL_miRNA);WNK3 (morbid/RE=ABC_enhancer);WNT10B (morbid/RE=mTL_miRNA);XK (morbid/RE=mTL_miRNA);YARS2 (morbid/RE=mTL_miRNA);ZBTB20 (morbid/RE=mTL_miRNA);ZBTB24 (morbid/RE=mTL_miRNA);ZBTB7A (morbid/RE=mTL_miRNA);ZFHX3 (morbid/RE=mTL_miRNA);ZMPSTE24 (morbid/RE=mTL_miRNA);ZNF644 (morbid/RE=mTL_miRNA) Xp11.22 region (includes HUWE1) TS3:ISCA-46299;dbVar:nssv15147941;dbVar:nssv15147942;dbVar:nssv15161312;nssv15161529;dbVar:nssv15161768 X:53276031-53298472;X:53283514-53325284;X:53363457-53793054;X:53559549-53622547;X:53559733-53790650 Cornelia de Lange syndrome 2, 300590 (3) XLD;Developmental and epileptic encephalopathy 85, with or without midline brain defects, 301044 (3) XLD;HSD10 mitochondrial disease, 300438 (3) XLD;Intellectual developmental disorder, XL 1, 309530 (3) XLD;Intellectual developmental disorder, XL syndromic, Turner type, 309590 (3) XL;Intellectual_disability,_X-linked_1 CLN:1065452;HI3:IQSEC2;HI3:SMC1A;dbVar:nssv15769470;dbVar:nssv16212358;dbVar:nssv16215156;dbVar:nssv17171530;dbVar:nssv17171900;dbVar:nssv17172048;dbVar:nssv17172462;dbVar:nssv17970926;dbVar:nssv17971164;dbVar:nssv18788536;dbVar:nssv18791522;morbid:HSD17B10;morbid:HUWE1;morbid:IQSEC2;morbid:SMC1A X:53253923-53254071;X:53262059-53350522;X:53263402-53280376;X:53264077-53264258;X:53264078-53264257;X:53270947-53271111;X:53279442-53280376;X:53295510-53310766;X:53348888-53349736;X:53401070-53449677;X:53401071-53449677;X:53430479-53432101;X:53430479-53442138;X:53435974-53442138;X:53448826-53449569;X:53449432-53449549;X:53458209-53461317;X:53559057-53713664 233 Abnormal_heart_valve_morphology;Congenital_muscular_hypertrophy-cerebral_syndrome;Cornelia_de_Lange_syndrome_1;Developmental_and_epileptic_encephalopathy,_85,_with_or_without_midline_brain_defects;Epileptic_encephalopathy;Global_developmental_delay;HSD10_mitochondrial_disease;Hirsutism;Hypertonia;Inborn_genetic_diseases;Intellectual_disability;Intellectual_disability,_X-linked_1;Intellectual_disability,_X-linked_syndromic,_Turner_type;Microcephaly;Neurodevelopmental_delay;Paraplegia-intellectual_disability-hyperkeratosis_syndrome;Progressive_sensorineural_hearing_impairment;SMC1A-related_cohesinopathy;See_cases;Severe_intellectual_deficiency;Syndromic_X-linked_intellectual_disability_Claes-Jensen_type;Undetermined_early-onset_epileptic_encephalopathy IMH X:46769178-84009828 0.1280 chrX:53351112-53351177 dbVar;chrX:53471700-53477100 dbVar;chrX:53592722-53593564 dbVar;chrX:53727000-53788500 dbVar;chrX:53787836-53829639 dbVar;chrX:53803200-53918400 dbVar; chrX:53332800-53414100 dbVar;chrX:53470041-53488385 dbVar;chrX:53552999-53623500 dbVar;chrX:53666546-53667044 dbVar;chrX:53775999-53852000 dbVar;chrX:53800000-53808000 dbVar;chrX:53820721-53862221 dbVar chrX:53318184-53318333 dbVar;chrX:53319071-53320350 dbVar;chrX:53414007-53419436 dbVar;chrX:53475340-53498420 dbVar;X:53478094-53491686 1000g;X:53478191-53491588 IMH;X:53478192-53491585 gnomAD-SV_v2.1_DEL_X_186301;chrX:53481193-53482847 dbVar;chrX:53485000-53555000 dbVar;X:53496417-53499888 1000g;chrX:53504537-53504627 dbVar;chrX:53513549-53520809 dbVar;chrX:53520678-53520750 dbVar;chrX:53561861-53562148 dbVar;chrX:53684764-53684885 dbVar;X:53772345-53778301 1000g;X:53772358-53778316 IMH;chrX:53776500-53781600 dbVar;chrX:53781934-53808203 dbVar;X:53792164-53792218 1000g;X:53800903-53801312 1000g... chrX:53256067-53256435 dbVar;chrX:53318309-53320696 dbVar;X:53319072-53320350 1000g;chrX:53437409-53437467 dbVar;chrX:53478093-53491686 dbVar;X:53478160-53491616 DDD:57601;chrX:53478192-53491585 dbVar;chrX:53478817-53479165 dbVar;X:53481194-53482847 1000g;chrX:53496416-53499888 dbVar;chrX:53496418-53499890 dbVar;chrX:53513441-53520776 dbVar;chrX:53513576-53513640 dbVar;chrX:53557344-53558918 dbVar;chrX:53680158-53680957 dbVar;chrX:53772344-53778301 dbVar;X:53772358-53778316 DDD:57606;chrX:53774645-53775785 dbVar;X:53776864-53777371 nsv515204;chrX:53787125-53795624 dbVar;chrX:53792164-53792218 dbVar... 0.420 0.295 X:53250479-53250649 MIRc X:53855851-53856180;X:53856303-53856465 L1MA7;L1MA7 3 75.6 0.807946261414963 9.03470791370173 314690;300522;300040;300256;300697 yes 0 1.0000e+00 1.0000e+00 1.0 1A (cf Gene_count, RE_gene, +0.00);2A (cf P_gain_source, +1.00);2H-2 (HSD17B10/HUWE1/IQSEC2/SMC1A, +0.00);2J (KDM5C, +0.00);3A (9 genes, +0.00);5F (+0.00) 5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 KDM5C NM_001353979 2 53205458 53254389 3736 150 3 no 26 txStart-intron1 5'UTR-CDS 555 3' 53250653 53254389 dbVar:nssv16215156 X:53253923-53254071 5 Inborn_genetic_diseases;Syndromic_X-linked_intellectual_disability_Claes-Jensen_type IMH X:46769178-84009828 0.1280 3 0 11.71 -1.20041549946446 5.44441583895939 X-linked syndromic intellectual disability;syndromic X-linked intellectual disability Claes-Jensen type XL;XLR Definitive;Strong;Supportive 10982473;15586325;15586325[PMID];16538222;18203167;18697827;19826449;21575681;22326837;25666439;32279304 8242 314690 Intellectual developmental disorder, XL syndromic, Claes-Jensen type, 300534 (3) XLR XLR yes 0 1.0000e+00 9.9784e-01 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 IQSEC2 NM_001111125 3 53262057 53350548 88491 4467 100 no 15 txStart-txEnd 5'UTR-3'UTR 53262057 53350548 dbVar:nssv15147941;dbVar:nssv15147942 X:53276031-53298472;X:53283514-53325284 Intellectual developmental disorder, XL 1, 309530 (3) XLD;Intellectual_disability,_X-linked_1 CLN:1065452;HI3:IQSEC2;dbVar:nssv17171900;dbVar:nssv17172048;dbVar:nssv17172462;dbVar:nssv17970926;dbVar:nssv18791522;morbid:IQSEC2 X:53262059-53350522;X:53263402-53280376;X:53264077-53264258;X:53264078-53264257;X:53270947-53271111;X:53279442-53280376;X:53295510-53310766;X:53348888-53349736 123 Inborn_genetic_diseases;Intellectual_disability;Intellectual_disability,_X-linked_1;Neurodevelopmental_delay;Paraplegia-intellectual_disability-hyperkeratosis_syndrome;See_cases;Severe_intellectual_deficiency;Undetermined_early-onset_epileptic_encephalopathy IMH X:46769178-84009828 0.1280 3 0 26.16 -0.257046228208263 4.55717824142058 X-linked complex neurodevelopmental disorder;intellectual disability, X-linked 1;non-syndromic X-linked intellectual disability;severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome XL;XLD Definitive;Strong;Supportive 20473311;20473311[PMID];21686261;23674175;23674175[PMID];24306141;25167861;26544041;26733290;26793055;27665735;28295038;28815955;29026562;300522;30206421;30666632;31415821;31490346;31829726 23096 300522 Intellectual developmental disorder, XL 1, 309530 (3) XLD XLD yes 0 9.9998e-01 9.7539e-01 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 SMC1A NM_006306 4 53401069 53449603 48534 3702 100 no 25 txStart-txEnd 5'UTR-3'UTR 53401069 53449603 dbVar:nssv15769470;dbVar:nssv16212358;dbVar:nssv17171530;dbVar:nssv17971164;dbVar:nssv18788536 X:53430479-53432101;X:53430479-53442138;X:53435974-53442138;X:53448826-53449569;X:53449432-53449549 90 Abnormal_heart_valve_morphology;Congenital_muscular_hypertrophy-cerebral_syndrome;Cornelia_de_Lange_syndrome_1;Developmental_and_epileptic_encephalopathy,_85,_with_or_without_midline_brain_defects;Epileptic_encephalopathy;Global_developmental_delay;Hirsutism;Hypertonia;Inborn_genetic_diseases;Intellectual_disability;Microcephaly;Progressive_sensorineural_hearing_impairment;SMC1A-related_cohesinopathy;See_cases IMH X:46769178-84009828 0.1280 3 0 14.23 -0.112682658348456 6.67845368195785 Cornelia de Lange syndrome;Cornelia de Lange syndrome 2;X-linked complex neurodevelopmental disorder;atypical Rett syndrome;developmental and epileptic encephalopathy, 85, with or without midline brain defects AD;XL;XLD Definitive;Strong;Supportive 16604071;17273969;20301283[PMID];20635401;22106055;24124034;26354354;26358754;26386245;27334371;28102598;28166369;28548707;31334757;32222533[PMID] 8243 300040 Cornelia de Lange syndrome 2, 300590 (3) XLD;Developmental and epileptic encephalopathy 85, with or without midline brain defects, 301044 (3) XLD XLD yes 0 1.0000e+00 9.9999e-01 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 MIR6857 NR_106916 1 53432604 53432697 93 0 0 no 1 txStart-txEnd UTR 53432604 53432697 IMH X:46769178-84009828 0.1280 102465516 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 RIBC1 NM_001031745 5 53449821 53458063 8242 1140 100 no 8 txStart-txEnd 5'UTR-3'UTR 53449821 53458063 IMH X:46769178-84009828 0.1280 75.6 0.80408198011521 0.293719819544616 158787 1 9.8300e-01 9.6626e-01 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 HSD17B10 NM_004493 3 53458208 53461317 3109 786 100 no 6 txStart-txEnd 5'UTR-3'UTR 53458208 53461317 HSD10 mitochondrial disease, 300438 (3) XLD morbid:HSD17B10 X:53458209-53461317 4 HSD10_mitochondrial_disease;Inborn_genetic_diseases;Neurodevelopmental_delay IMH X:46769178-84009828 0.1280 0 0 21.63 0.807946261414963 2.17074250392365 HSD10 disease, infantile type;HSD10 disease, neonatal type;HSD10 mitochondrial disease;syndromic X-linked intellectual disability type 10 XL;XLR Definitive;Strong;Supportive 10521307;12555940;12696021;16148061;22127393;22127393[PMID] 3028 300256 HSD10 mitochondrial disease, 300438 (3) XLD XLD yes 1 9.3604e-01 8.8687e-01 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 HUWE1 NM_031407 7 53559056 53713664 154608 13125 100 no 84 txStart-txEnd 5'UTR-3'UTR 53559056 53713664 dbVar:nssv15161768 X:53559549-53622547 Intellectual developmental disorder, XL syndromic, Turner type, 309590 (3) XL morbid:HUWE1 X:53559057-53713664 11 Global_developmental_delay;Inborn_genetic_diseases;Intellectual_disability;Intellectual_disability,_X-linked_syndromic,_Turner_type;Neurodevelopmental_delay IMH X:46769178-84009828 0.1280 0 0 10.58 -1.65771922174252 9.03470791370173 intellectual disability, X-linked syndromic, Turner type;non-syndromic X-linked intellectual disability;syndromic intellectual disability AD;XL;XLD Definitive;Strong;Supportive 18252223;19377476;1968668;20231446;22840365;23721686;24303071;25644381;25985138;27418510;27615324;29180823;29180823[PMID] 10075 300697 Intellectual developmental disorder, XL syndromic, Turner type, 309590 (3) XL XL yes 0 1.0000e+00 1.0000e+00 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 MIR98 NR_029513 1 53583183 53583302 119 0 0 no 1 txStart-txEnd UTR 53583183 53583302 dbVar chrX:53552999-53623500 0.01 IMH X:46769178-84009828 0.1280 407054 full=5 +X_53250654_53856257_DUP_1 X 53250654 53856257 605603 DUP HUWE1 Pathogenic NA split p11.22 MIRLET7F2 NR_029484 1 53584152 53584235 83 0 0 no 1 txStart-txEnd UTR 53584152 53584235 dbVar chrX:53552999-53623500 0.01 IMH X:46769178-84009828 0.1280 406889 full=5 +11_66287089_66288847_DEL_1 11 66287089 66288847 -1758 DEL BBS1 internal frameshift Pathogenic NA full q13.2 BBS1;ZDHHC24 DPP3 ACTN3 2 BANF1 (morbid/RE=EA_enhancer);C11orf80 (morbid/RE=EA_enhancer);CATSPER1 (morbid/RE=EA_enhancer);CTSF (morbid/RE=EA_enhancer);FIBP (morbid/RE=EA_enhancer);KLC2 (morbid/RE=EA_enhancer);PACS1 (morbid/RE=EA_enhancer);PC (morbid/RE=EA_enhancer);SF3B2 (morbid/RE=EA_enhancer);SPTBN2 (morbid/RE=EA_enhancer);TMEM151A (morbid/RE=EA_enhancer) dbVar:nssv15171978;dbVar:nssv15158476;dbVar:nssv15150306;nssv15150623;dbVar:nssv17976763;dbVar:nssv15150659;dbVar:nssv15605814;dbVar:nssv15146474;dbVar:nssv17973682 11:70865-134938470;11:198511-134934063;11:230617-134938470;11:32799482-134938470;11:64501920-67129258;11:65138977-67574402;11:65960974-67658241;11:66281868-66288857 0.00;0.00;0.00;0.00;0.07;0.07;0.10;25.16 Bardet-Biedl syndrome 1, 209900 (3) Digenic recessive,AR dbVar:nssv16867095;dbVar:nssv15148225;dbVar:nssv15129970;dbVar:nssv18792809;morbid:BBS1;dbVar:nssv16214536;dbVar:nssv17171795;dbVar:nssv16212285;dbVar:nssv17976607;dbVar:nssv17974991;dbVar:nssv17172605;dbVar:nssv16212781;dbVar:nssv18787680;dbVar:nssv15128612;dbVar:nssv17172606 11:11835570-118373112;11:65508903-67473140;11:66274841-66292574;11:66274871-66292647;11:66278106-66301069;11:66278112-66291373;11:66278112-66299528;11:66278122-66291682;11:66278712-66293593;11:66283002-66287229;11:66283155-66287229;11:66287079-66288857;11:66287079-66291105;11:66288384-66293649;11:66288722-66293683 0.00;0.09;9.92;9.89;7.66;13.26;8.21;12.97;11.82;3.33;3.46;98.88;43.68;8.81;2.54 11 BBS1-related_condition;Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_1;Retinal_dystrophy IMH 11:1642920-71249653;11:49233128-89368291;11:49425032-89029881;11:49425381-89029675;11:49580506-88798755;11:49652145-88728247;11:50025478-108975588 0.4320 chr11:66272212-66288041 dbVar 0.565 0.545 67.28 -0.648300458519823 0.663432885116562 0.155145712015149 0.635599914039232 1.04727080312339 209901 yes 5 4.2080e-04 6.1403e-03 0.9 1A (cf Gene_count, RE_gene, +0.00);2E-1 (BBS1, +0.90);3A (2 genes, +0.00);5F (+0.00) 4 +11_66287089_66288847_DEL_1 11 66287089 66288847 -1758 DEL BBS1 internal frameshift Pathogenic NA split q13.2 BBS1 NM_024649 5 66278105 66301069 1759 238 13 yes 17 exon8-intron9 CDS 0 5' 66287088 66288847 11 BBS1-related_condition;Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_1;Retinal_dystrophy IMH 11:1642920-71249653;11:49233128-89368291;11:49425032-89029881;11:49425381-89029675;11:49580506-88798755;11:49652145-88728247;11:50025478-108975588 0.4320 40.7 -0.648300458519823 0.663432885116562 0.155145712015149 0.0819191978639822 0.0377121632347663 Bardet-Biedl syndrome;Bardet-Biedl syndrome 1 AR Definitive;Strong;Supportive 10577921;10577922;12118255;12524598;12837689;18032602;20177705;20301537[PMID];20498079;23143442 582 209901 Bardet-Biedl syndrome 1, 209900 (3) Digenic recessive,AR Digenic recessive,AR yes 5 3.4063e-12 1.7787e-07 full=4 +11_66287089_66288847_DEL_1 11 66287089 66288847 -1758 DEL BBS1 internal frameshift Pathogenic NA split q13.2 ZDHHC24 NM_001348571 2 66288095 66313519 752 0 0 no 5 exon5-txEnd 3'UTR 90 3' 66288095 66288847 4 BBS1-related_condition;Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_1;Retinal_dystrophy IMH 11:1642920-71249653;11:49233128-89368291;11:49425032-89029881;11:49425381-89029675;11:49580506-88798755;11:49652145-88728247;11:50025478-108975588 0.4320 67.28 -1.23986898178133 0.616417349113344 -0.188374414893838 0.635599914039232 1.04727080312339 254359 7 4.2080e-04 6.1403e-03 full=4 +7_33397468_33397607_DEL_1 7 33397468 33397607 -139 DEL BBS9 inframe Pathogenic NA full p14.3 BBS9 RP9 FLJ20712 1 dbVar:nssv15777247;dbVar:nssv15168013;dbVar:nssv15161666;nssv15161679;dbVar:nssv15168014;dbVar:nssv15161745;dbVar:nssv15161726;dbVar:nssv17970196;dbVar:nssv15161869;dbVar:nssv15161632;dbVar:nssv17970205;dbVar:nssv15133397;dbVar:nssv15154527;dbVar:nssv15146465 7:10366-159119707;7:10705-159122532;7:43362-159119707;7:44936-159126310;7:54186-37129317;7:54186-41915483;7:10745751-35305167;7:11048841-52863626;7:11562625-36395416;7:27507833-39072473;7:30460550-34600277;7:30463887-43470805;7:33367925-61831899 0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00 Bardet-Biedl syndrome 9, 615986 (3) AR dbVar:nssv15161318;dbVar:nssv17976840;dbVar:nssv18329275;dbVar:nssv15138559;dbVar:nssv15147510;dbVar:nssv15148432;morbid:BBS9;dbVar:nssv17971381;dbVar:nssv18790316;dbVar:nssv18790317 7:54186-159075079;7:25451741-33864069;7:27133787-34466477;7:30977986-33440608;7:32718004-41084581;7:32911004-44576005;7:33169176-33675379;7:33296829-33427776;7:33376034-33427776;7:33388661-33397627 0.00;0.00;0.00;0.01;0.00;0.00;0.03;0.11;0.27;1.56 1 Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_9 dbVar chr7:32726588-35070337 0.01 IMH 7:23891013-65526751;7:33013222-55782515 0.3810 chr7:32726588-35070337 dbVar 0.325 0.370 17.13 -2.43637392050626 -2.53125239294469 -2.47162789907313 -0.989035894351638 -1.15018109964609 607968 yes 4 4.2117e-17 6.3752e-10 0.9 1A (cf Gene_count, RE_gene, +0.00);2E-1 (BBS9, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +7_33397468_33397607_DEL_1 7 33397468 33397607 -139 DEL BBS9 inframe Pathogenic NA split p14.3 BBS9 NM_001348036 1 33168896 33645680 140 140 5 yes 23 exon16-intron16 CDS 0 5' 33397467 33397607 1 Bardet-Biedl_syndrome;Bardet-Biedl_syndrome_9 dbVar chr7:32726588-35070337 0.01 IMH 7:23891013-65526751;7:33013222-55782515 0.3810 17.13 -2.43637392050626 -2.53125239294469 -2.47162789907313 -0.989035894351638 -1.15018109964609 Bardet-Biedl syndrome;Bardet-Biedl syndrome 9 AR Definitive;Strong;Supportive 16380913;20177705;20301537[PMID];21209035;22353939;250490;251248;268436;282550 27241 607968 Bardet-Biedl syndrome 9, 615986 (3) AR AR yes 4 4.2117e-17 6.3752e-10 full=4 +12_63935482_64130626_DUP_1 12 63935482 64130626 195144 DUP DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA full q14.2 DPY19L2 AVPR1A RXYLT1 1 RXYLT1 (morbid/RE=GH_enhancer);TBK1 (morbid/RE=EA_enhancer) Spermatogenic failure 9, 613958 (3) AR dbVar:nssv15119764;dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63952694-64062354;12:63989747-63989817 dbVar:nssv15161620;dbVar:nssv15161414;nssv15161422;dbVar:nssv15171852;dbVar:nssv15161798;dbVar:nssv15171855 12:2-133851895;12:173788-133777902;12:191620-133777645;12:282466-133773393;12:621221-133779118 0.15;0.15;0.15;0.15;0.15 dbVar:nssv15136921 12:61300933-66961857 3.45 1 Spermatogenic_failure_9 IMH 12:11501488-96031049;12:40933234-113477160 0.1070 chr12:63936386-64131550 dbVar;chr12:63939158-64117235 dbVar;12:63939159-64117235 esv3629757;chr12:63944788-63947354 dbVar;chr12:63965589-63975135 dbVar;chr12:63988950-64000500 dbVar;chr12:64010193-64011854 dbVar;chr12:64011854-64015265 dbVar;12:64020291-64020367 DDD:38896;12:64069043-64136500 dgv280e214;chr12:64077066-64077827 dbVar;chr12:64078873-64107227 dbVar;chr12:64117634-64120295 dbVar;chr12:64129133-64134963 dbVar;chr12:63936386-64131550 dbVar;chr12:63939158-64117235 dbVar;12:63939159-64117235 esv3629757;chr12:63944788-63947354 dbVar;chr12:63965589-63975135 dbVar;chr12:63988950-64000500 dbVar;chr12:64010193-64011854 dbVar... chr12:63935000-63948000 dbVar;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888;chr12:63950451-64144961 dbVar;chr12:63965589-64010193 dbVar;chr12:63998600-64077000 dbVar;chr12:64010193-64015265 dbVar;chr12:64011854-64021530 dbVar;chr12:64061735-64073704 dbVar;chr12:64073704-64076066 dbVar;chr12:64078873-64079823 dbVar;chr12:64089900-64096000 dbVar;chr12:64125000-64130000 dbVar;chr12:63935000-63948000 dbVar;12:63936386-64131550 gnomAD-SV_v2.1_DUP_12_34997;12:63939159-64117235 1000g;12:63940549-64135811 DDD:38888;chr12:63950451-64144961 dbVar;chr12:63965589-64010193 dbVar;chr12:63998600-64077000 dbVar... chr12:63936000-63986000 dbVar;chr12:63946269-64141505 dbVar;chr12:63946732-63946956 dbVar;12:63946733-63946956 IMH;chr12:63959839-63959910 dbVar;12:64020291-64020367 DDD:38896;chr12:64069257-64069348 dbVar;chr12:64076528-64076585 dbVar;chr12:64116494-64116881 dbVar;chr12:63923277-64119251 dbVar;chr12:63939158-64117235 dbVar;12:63946730-63946956 esv2662353;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265;chr12:63950172-63950241 dbVar;chr12:64015848-64018740 dbVar;chr12:64065000-64130000 dbVar;chr12:64069869-64069961 dbVar;chr12:64103835-64106468 dbVar;chr12:64122000-64127000 dbVar chr12:63923277-64119251 dbVar;chr12:63939158-64117235 dbVar;12:63946730-63946956 esv2662353;12:63946732-63946956 gnomAD-SV_v2.1_DEL_12_129265;chr12:63950172-63950241 dbVar;chr12:64015848-64018740 dbVar;chr12:64065000-64130000 dbVar;chr12:64069869-64069961 dbVar;chr12:64103835-64106468 dbVar;chr12:64122000-64127000 dbVar;chr12:63936000-63986000 dbVar;chr12:63946269-64141505 dbVar;chr12:63946732-63946956 dbVar;12:63946733-63946956 IMH;chr12:63959839-63959910 dbVar;12:64020291-64020367 DDD:38896;chr12:64069257-64069348 dbVar;chr12:64076528-64076585 dbVar;chr12:64116494-64116881 dbVar 350981;2692928;1491350;1087307;2792491;2353750;2965163;1209828;1619448;1883558;2814116;1194770;2089432;31158;2419380;119292;287527;981327;1267803;1760195;174035;1054499;1054500;693309;1328263;1881832;2850280 loss;gain 0.530 0.430 12:63935369-63935656 AluSq2 12:64130409-64130696 AluSq2 12:63923419-63951619 12:64119249-64146247 81.13 1.02618176351368 1.66555804568279 613893 yes 4 1.0936e-13 7.0294e-05 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2G (cf po_B_gain_someG_source, +0.00)2H-2 (DPY19L2, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 +12_63935482_64130626_DUP_1 12 63935482 64130626 195144 DUP DPY19L2 (both DEL and DUP LCR mediated, precise breakpoints) Pathogenic NA split q14.2 DPY19L2 NM_173812 5 63952692 64062273 109581 2277 100 no 22 txStart-txEnd 5'UTR-3'UTR 63952692 64062273 Spermatogenic failure 9, 613958 (3) AR dbVar:nssv16213932;morbid:DPY19L2 12:63952693-64062273;12:63989747-63989817 1 Spermatogenic_failure_9 1000g;DDD:38888;dbVar;esv3629757;gnomAD-SV_v2.1_DUP_12_34997 chr12:63936386-64131550;12:63936386-64131550;chr12:63939158-64117235;12:63939159-64117235;12:63939159-64117235;12:63940549-64135811;chr12:63950451-64144961 0.0257 dbVar chr12:63923277-64119251;chr12:63939158-64117235;chr12:63946269-64141505 0.01 IMH 12:11501488-96031049;12:40933234-113477160 0.1070 1267803;1760195;1054499;1054500 loss;gain 81.13 1.02618176351368 1.66555804568279 male infertility due to globozoospermia;spermatogenic failure 9 AR Strong;Supportive 17008355;21397063;21397063[PMID]_22571172[PMID];21397064;22627659;22653751;25755131;25780569 283417 613893 Spermatogenic failure 9, 613958 (3) AR AR yes 4 1.0936e-13 7.0294e-05 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA full p11.1-p11.2 LOC102723753;HERC2P4;TP53TG3D;LOC390705;LOC107987382;TP53TG3;SLC6A10P;TP53TG3C;LOC105369266;TP53TG3B;LOC107987386;ENPP7P13;MIR9901;CCNYL3;UBE2MP1;LOC112268173;LINC01566 ZNF267 FRG2DP 17 ARMC5 (morbid/RE=GH_promoter) dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv16216874;dbVar:nssv15126545;dbVar:nssv15133058;dbVar:nssv15126469;dbVar:nssv15150356 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:5805002-34230001;16:24381954-33923059;16:30703234-35147508;16:31986099-90294753;16:34197493-64509054 3.04;3.05;3.05;3.05;3.05;8.00;20.63;61.82;4.66;1.67 dbVar:nssv15141243 16:28826163-34375007 43.61 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 16:31749454-34012168 dgv50e203;chr16:31972000-31977000 dbVar;chr16:31988999-32093700 dbVar;16:31989000-32033000 gnomAD-SV_v2.1_DUP_16_42016;chr16:31998945-32000382 dbVar;chr16:32000382-32163177 dbVar;chr16:32020000-32026200 dbVar;16:32020000-32096000 TS40:ISCA-46491;16:32020000-32096000 gnomAD-SV_v2.1_DUP_16_42022;chr16:32042250-32083000 dbVar;chr16:32092602-32163177 dbVar;16:32127000-32132000 gnomAD-SV_v2.1_DUP_16_42024;16:32128500-32133600 gnomAD-SV_v2.1_DUP_16_42025;chr16:32150000-32329000 dbVar;16:32193431-32193767 DDD:47069;16:32202950-32209100 gnomAD-SV_v2.1_DUP_16_42026;16:32232000-32237100 gnomAD-SV_v2.1_DUP_16_42027;chr16:32328771-32370968 dbVar;16:32328772-32370968 1000g;chr16:32328900-32377200 dbVar;chr16:32366481-32410672 dbVar... chr16:31669999-31991400 dbVar;chr16:31969000-31997000 dbVar;16:31985111-31985155 DDD:47053;chr16:31989000-32033000 dbVar;chr16:31998194-32020170 dbVar;chr16:32000382-32092602 dbVar;chr16:32008999-32020100 dbVar;16:32020000-32026200 gnomAD-SV_v2.1_DUP_16_42021;chr16:32020000-32096000 dbVar;chr16:32029000-32037000 dbVar;16:32055083-33851279 DDD:47058;16:32123333-33664028 DDD:47062;chr16:32127889-32379212 dbVar;16:32129166-32904510 DDD:47063;chr16:32163177-32379212 dbVar;chr16:32202950-32209100 dbVar;chr16:32232000-32237100 dbVar;16:32257510-32714406 esv2421440;16:32328772-32370968 1000g;16:32328772-32370968 dgv504e214;16:32345385-33344188 IMH... chr16:31933999-31991400 dbVar;chr16:31986799-32041500 dbVar;chr16:31998194-32020170 dbVar;chr16:32036000-32041500 dbVar;16:32055083-33851279 DDD:47058;16:32129166-32904510 DDD:47063;chr16:32289883-32289979 dbVar;16:32298051-32812316 DDD:47074;chr16:32328771-32370968 dbVar;chr16:32366481-32410672 dbVar;chr16:32393247-32393542 dbVar;chr16:32473466-32473664 dbVar;16:32485788-32648832 DDD:47081;16:32489448-32622550 dgv4e224;chr16:32494596-32496820 dbVar;chr16:32511665-32511727 dbVar;16:32524651-32525229 IMH;16:32532282-32533735 IMH;16:32562331-32601372 IMH;chr16:32586298-32586783 dbVar;16:32588181-32590788 1000g... 16:31749454-34012168 dgv50e203;chr16:31971409-31971474 dbVar;chr16:31986800-31999150 dbVar;chr16:32010600-32020000 dbVar;16:32052946-32496748 DDD:47057;16:32123333-33664028 DDD:47062;16:32257510-32714406 esv2421440;chr16:32294372-32294452 dbVar;chr16:32312790-32313754 dbVar;16:32328772-32370968 1000g;chr16:32373626-32373758 dbVar;chr16:32418983-32469917 dbVar;chr16:32485126-32485204 dbVar;16:32486808-32486871 DDD:47084;chr16:32491490-32496732 dbVar;16:32511180-32878155 dgv819e212;16:32518848-32519371 IMH;16:32525918-32525974 IMH;16:32541493-32648861 DDD:47087;16:32562341-32600296 IMH;chr16:32588180-32590788 dbVar... 867177;91567;353034;353631;846410;889780;602068;920215;656674;844820;928993;916990;882610;882781;913386;921568;602754;906717;909308;917780;926463;907306;918212;883393;881329;893721;893981;899737;917511;923245;924117;2606399;1093900;1094650;1192145;1453959;2693617;2151152;2692204;2913452;2253963;2648708;1487532;2616160;2182684;2494773;2639896;73921;926125;915894;606563;... gain;loss 0.225 0.335 16:31948879-31955047;16:31955090-31955836 L1PA3;L1M4c 94.39 1.56757328357025 2.11426077975333 9 7.5995e-03 6.4106e-01 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2G (cf po_B_gain_someG_source, +0.00)3A (17 genes, +0.00);5F (+0.00) 3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC102723753 NR_135178 1 32163432 32199434 36002 0 0 no 25 txStart-txEnd UTR 32163432 32199434 DDD:47058;DDD:47062;DDD:47063;dbVar;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;chr16:32127889-32379212;16:32129166-32904510;chr16:32150000-32329000;chr16:32163177-32379212 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:31749454-34012168;16:32052946-32496748;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510 0.1692 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 HERC2P4 NR_109773 1 32181363 32199434 18071 0 0 no 14 txStart-txEnd UTR 32181363 32199434 DDD:47058;DDD:47062;DDD:47063;dbVar;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;chr16:32127889-32379212;16:32129166-32904510;chr16:32150000-32329000;chr16:32163177-32379212 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:31749454-34012168;16:32052946-32496748;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510 0.1692 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 100289574 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3D NM_001243722 3 32264606 32267249 2643 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32264606 32267249 DDD:47058;DDD:47062;DDD:47063;dbVar;dgv50e203;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;chr16:32127889-32379212;16:32129166-32904510;chr16:32150000-32329000;chr16:32163177-32379212;16:32257510-32714406 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;dgv50e203;esv2421440 16:31749454-34012168;16:32052946-32496748;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406 0.2300 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 92.49 1.56757328357025 2.11426077975333 729264 9 7.5995e-03 6.4106e-01 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC390705 NR_033866 1 32300867 32301302 435 0 0 no 1 txStart-txEnd UTR 32300867 32301302 DDD:47058;DDD:47062;DDD:47063;dbVar;dgv50e203;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;chr16:32127889-32379212;16:32129166-32904510;chr16:32150000-32329000;chr16:32163177-32379212;16:32257510-32714406 0.1314 DDD:47057;DDD:47058;DDD:47062;DDD:47063;DDD:47074;dgv50e203;esv2421440 16:31749454-34012168;16:32052946-32496748;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316 0.2300 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC107987382 NR_171659 1 32611681 32626892 15211 0 0 no 8 txStart-txEnd UTR 32611681 32626892 1000g;DDD:47058;DDD:47062;DDD:47063;DDD:47091;IMH;dbVar;dgv507e214;dgv50e203;dgv821e212;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32345385-33344188;chr16:32471402-32942494;chr16:32490199-32627933;chr16:32490199-32942494;16:32511180-33912324;16:32589803-32684945;chr16:32603879-32651988;chr16:32611029-32642738;16:32611030-32642738;16:32611030-32642738;16:32611030-32642738 0.8086 DDD:47058;DDD:47062;DDD:47063;DDD:47074;DDD:47081;DDD:47087;DDD:47091;DDD:47092;dbVar;dgv50e203;dgv819e212;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:32485788-32648832;16:32511180-32878155;16:32541493-32648861;16:32589803-32684945;16:32590685-32653097;chr16:32611029-32642738 0.2300 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3 NM_016212 5 32684850 32687486 2636 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684850 32687486 DDD:47058;DDD:47062;DDD:47063;IMH;dbVar;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32345385-33344188;chr16:32471402-32942494;chr16:32490199-32942494;16:32511180-33912324;chr16:32651988-32942494;16:32659200-32810000;16:32663000-32707000;16:32664500-32696000 0.3314 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dbVar;dgv50e203;dgv819e212;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:32511180-32878155;16:32656000-32802000;chr16:32656000-32802000 0.2300 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 94.39 24150 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 SLC6A10P NR_003083 3 32888793 32896463 7670 0 0 no 9 txStart-txEnd UTR 32888793 32896463 DDD:47058;DDD:47062;DDD:47063;IMH;dbVar;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32345385-33344188;chr16:32471402-32942494;chr16:32490199-32942494;16:32511180-33912324;chr16:32651988-32942494 0.3314 DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510 0.1692 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 386757 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3C NM_001205259 3 33205546 33208179 2633 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 33205546 33208179 DDD:47058;DDD:47062;DDD:47113;IMH;dbVar;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;chr16:33106071-33292140;16:33204449-33378738 0.3314 DDD:47058;DDD:47062;DDD:47113;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738 0.0715 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 91.96 653550 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC105369266 NR_158162 1 33215160 33232409 17249 0 0 no 6 txStart-txEnd UTR 33215160 33232409 DDD:47058;DDD:47062;DDD:47113;IMH;dbVar;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;chr16:33106071-33292140;16:33204449-33378738 0.3314 DDD:47058;DDD:47062;DDD:47113;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738 0.0715 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 TP53TG3B NM_001099687 4 33262081 33264719 2638 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 33262081 33264719 DDD:47058;DDD:47062;DDD:47113;DDD:47114;IMH;dbVar;dgv50e203;dgv821e212;gnomAD-SV_v2.1_DUP_16_42042 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;chr16:33106071-33292140;16:33204449-33378738;16:33230271-33739925;16:33237000-33295200 0.3314 DDD:47058;DDD:47062;DDD:47113;DDD:47114;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738;16:33230271-33739925 0.1243 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 92.24 729355 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC107987386 NR_171660 1 33298270 33319296 21026 0 0 no 5 txStart-txEnd UTR 33298270 33319296 DDD:47058;DDD:47062;DDD:47113;DDD:47114;DDD:47116;IMH;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;16:33204449-33378738;16:33230271-33739925;16:33270420-33827235 0.5150 DDD:47058;DDD:47062;DDD:47113;DDD:47114;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738;16:33230271-33739925 0.1243 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 ENPP7P13 NR_130771 1 33571843 33586742 14899 0 0 no 3 txStart-txEnd UTR 33571843 33586742 DDD:47058;DDD:47062;DDD:47114;DDD:47116;DDD:47126;DDD:47131;DDD:47136;dbVar;dgv50e203;dgv821e212;nsv514803 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324;16:33230271-33739925;16:33270420-33827235;16:33302092-33630727;16:33473790-33628580;16:33526621-33659628;chr16:33549000-33642000;chr16:33551705-33589259;chr16:33551705-33589453;16:33560604-33662009;chr16:33561954-33589259;chr16:33566225-33589259;chr16:33569214-33589259 0.5150 DDD:47058;DDD:47062;DDD:47114;DDD:47126;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33230271-33739925;16:33473790-33628580 0.1243 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 104644205 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 MIR9901 NR_162093 1 33966044 33966140 96 0 0 no 1 txStart-txEnd UTR 33966044 33966140 dgv50e203 16:31749454-34012168 0.0700 dgv50e203 16:31749454-34012168 0.0500 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 113218496 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 CCNYL3 NR_158158 1 34264719 34294699 29980 0 0 no 11 txStart-txEnd UTR 34264719 34294699 TS40:ISCA-37481;dbVar;dgv51e203;nsv516385 chr16:34189000-34557000;16:34197352-35283226;16:34202089-35147508;16:34259806-34805859 0.0600 HI40:ISCA-37481;dbVar chr16:34197000-34310700;chr16:34197000-34434000;16:34202089-35147508 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 102724928 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 UBE2MP1 NR_002837 1 34403801 34404762 961 0 0 no 1 txStart-txEnd UTR 34403801 34404762 TS40:ISCA-37481;dbVar;dgv51e203;nsv516385 chr16:34189000-34557000;16:34197352-35283226;16:34202089-35147508;16:34259806-34805859 0.0600 HI40:ISCA-37481;dbVar chr16:34197000-34434000;16:34202089-35147508 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 606551 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.2 LOC112268173 NR_157261 1 34430129 34431919 1790 0 0 no 1 txStart-txEnd UTR 34430129 34431919 TS40:ISCA-37481;dbVar;dgv117e55;dgv51e203;nsv516385 chr16:34189000-34557000;16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531 0.0900 HI40:ISCA-37481;dbVar chr16:34197000-34434000;16:34202089-35147508 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 full=3 +16_31955077_34702366_DUP_1 16 31955077 34702366 2747289 DUP Benign NA split p11.1-p11.2 LINC01566 NR_027080 2 34597786 34626084 28298 0 0 no 7 txStart-txEnd UTR 34597786 34626084 1000g;DDD:47173;DDD:47179;DDD:47183;TS40:ISCA-37481;dbVar;dgv117e55;dgv2962n100;dgv51e203;dgv824e212;esv2421698;esv3638500;gnomAD-SV_v2.1_DUP_16_42078;gnomAD-SV_v2.1_DUP_16_42081;nsv514804;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531;16:34441796-34784591;16:34445084-34774280;16:34456525-34736855;chr16:34456676-34760206;chr16:34457085-34712399;16:34457086-34712399;16:34457086-34712399;chr16:34465000-34757000;16:34465000-34757000;16:34470705-34757071;16:34471852-34731191;16:34476781-34747070;16:34567146-34656231;chr16:34572795-34661165;16:34572795-34661165;chr16:34579398-34644534;chr16:34579398-34687954 0.1875 HI40:ISCA-37481;dbVar 16:34202089-35147508;chr16:34457085-34712399 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 283914 full=3 +16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA full p11.2 ENPP7P13;MIR9901;CCNYL3 LOC107987386 UBE2MP1 3 dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv16216874;dbVar:nssv15126545;dbVar:nssv15133058;dbVar:nssv15126469;dbVar:nssv15150356 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:5805002-34230001;16:24381954-33923059;16:30703234-35147508;16:31986099-90294753;16:34197493-64509054 1.01;1.01;1.02;1.02;1.01;3.02;5.78;20.57;1.57;0.29 dbVar:nssv15141243 16:28826163-34375007 16.48 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 16:32055083-33851279 DDD:47058;16:32511180-33912324 dgv821e212;16:33230271-33739925 DDD:47114;16:33302092-33630727 nsv514803;chr16:33376000-33520200 dbVar;16:33406659-33406773 IMH;16:33446164-33480261 1000g;16:33446164-33480261 dgv510e214;16:33467710-33467710 1000g;16:33470756-33495606 1000g;16:33470756-33495606 dgv511e214;chr16:33484521-33543753 dbVar;16:33484522-33543753 1000g;chr16:33487822-33530645 dbVar;chr16:33491040-33527971 dbVar;chr16:33491040-33566225 dbVar;16:33524566-33570784 1000g;16:33524566-33570784 dgv513e214;chr16:33525298-33566225 dbVar;chr16:33549000-33642000 dbVar;chr16:33551705-33572203 dbVar... 16:31749454-34012168 dgv50e203;16:32123333-33664028 DDD:47062;16:33204449-33378738 DDD:47113;16:33270420-33827235 DDD:47116;chr16:33342500-33372600 dbVar;16:33376004-33548487 DDD:47124;chr16:33446163-33480261 dbVar;16:33446164-33480261 1000g;16:33464249-33499453 DDD:47125;chr16:33470755-33495606 dbVar;16:33470756-33495606 1000g;16:33473790-33628580 DDD:47126;16:33484522-33543753 1000g;16:33484522-33543753 dgv512e214;chr16:33491040-33525298 dbVar;chr16:33491040-33530645 dbVar;chr16:33524565-33570784 dbVar;16:33524566-33570784 1000g;chr16:33525298-33530645 dbVar;16:33526621-33659628 DDD:47131;chr16:33551705-33566225 dbVar... 16:32055083-33851279 DDD:47058;16:33204449-33378738 DDD:47113;chr16:33429584-33429643 dbVar;16:33433594-33433957 gnomAD-SV_v2.1_DEL_16_153879;chr16:33462282-33462339 dbVar;16:33464249-33499453 DDD:47125;chr16:33470755-33495606 dbVar;16:33473790-33628580 DDD:47126;16:33486471-33490892 DDD:47128;chr16:33524565-33570784 dbVar;16:33537417-33539750 esv2656732;chr16:33545163-33547147 dbVar;chr16:33559201-33559298 dbVar;chr16:33560642-33560933 dbVar;16:33582387-33629628 DDD:47138;16:33586836-33590310 1000g;chr16:33588532-33626594 dbVar;16:33589117-33599697 1000g;chr16:33597522-33597696 dbVar;16:33604896-33605259 gnomAD-SV_v2.1_DEL_16_153891;chr16:33604997-33605259 dbVar... 16:31749454-34012168 dgv50e203;16:32123333-33664028 DDD:47062;16:33230271-33739925 DDD:47114;chr16:33433594-33433957 dbVar;chr16:33446163-33480261 dbVar;16:33462282-33462339 gnomAD-SV_v2.1_DEL_16_153880;chr16:33467950-33468051 dbVar;chr16:33472157-33472229 dbVar;chr16:33484521-33543753 dbVar;chr16:33509280-33509607 dbVar;chr16:33529598-33529692 dbVar;chr16:33543857-33545591 dbVar;chr16:33556576-33556850 dbVar;16:33559201-33559298 gnomAD-SV_v2.1_DEL_16_153886;chr16:33564729-33565655 dbVar;chr16:33586835-33590310 dbVar;16:33586836-33590310 esv3638472;chr16:33589116-33599697 dbVar;16:33589117-33599697 esv3638477;chr16:33604896-33605259 dbVar;16:33604997-33605259 1000g... 781016;913793;843787;1699997;2426917;2490784;1685031;659811;699973;670782;680374;660677;672361;684689;664618;671843;657664;681578;1023638;681053;673067;674709;646530;678393;702587;664135;663042;647522;653368;687753;685072;679826;676289;682295;659028;678813;676795;677228;668304;693340;690593;700712;655764;667457;669103;913541;669215;864084;751902;647806;864730;... gain;loss 0.430 0.365 16:33371221-33371434 AluSz6 16:33241272-33372204;16:33325624-33372204;16:33330495-33372204;16:33330495-33372204;16:33342946-33372204;16:33353245-33373923;16:33355202-33372204;16:33363548-33517471 16:32923001-33427100 High Signal Region 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2G (cf po_B_gain_someG_source, +0.00)2L (CCNYL3, +0.00);3A (3 genes, +0.00);5F (+0.00) 3 +16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA split p11.2 ENPP7P13 NR_130771 1 33571843 33586742 14899 0 0 no 3 txStart-txEnd UTR 33571843 33586742 DDD:47058;DDD:47062;DDD:47114;DDD:47116;DDD:47126;DDD:47131;DDD:47136;dbVar;dgv50e203;dgv821e212;nsv514803 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32511180-33912324;16:33230271-33739925;16:33270420-33827235;16:33302092-33630727;16:33473790-33628580;16:33526621-33659628;chr16:33549000-33642000;chr16:33551705-33589259;chr16:33551705-33589453;16:33560604-33662009;chr16:33561954-33589259;chr16:33566225-33589259;chr16:33569214-33589259 0.5150 DDD:47058;DDD:47062;DDD:47114;DDD:47126;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33230271-33739925;16:33473790-33628580 0.1243 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 104644205 full=3 +16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA split p11.2 MIR9901 NR_162093 1 33966044 33966140 96 0 0 no 1 txStart-txEnd UTR 33966044 33966140 dgv50e203 16:31749454-34012168 0.0700 dgv50e203 16:31749454-34012168 0.0500 IMH 16:24121264-80276578;16:29238285-88227116 0.4996 113218496 full=3 +16_33371444_34285848_DUP_1 16 33371444 34285848 914404 DUP Benign NA split p11.2 CCNYL3 NR_158158 1 34264719 34294699 21129 0 0 no 11 txStart-intron9 UTR 82 5' 34264719 34285848 TS40:ISCA-37481;dbVar;dgv51e203;nsv516385 chr16:34189000-34557000;16:34197352-35283226;16:34202089-35147508;16:34259806-34805859 0.0600 HI40:ISCA-37481;dbVar chr16:34197000-34310700;chr16:34197000-34434000;16:34202089-35147508 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 102724928 full=3 +5_723195_777000_DUP_1 5 723195 777000 53805 DUP Benign NA full p15.33 ZDHHC11B TPPP ZDHHC11 1 NDUFS6 (morbid/RE=ABC_enhancer);SDHA (morbid/RE=EA_enhancer);SLC9A3 (morbid/RE=GH_enhancer);TRIP13 (morbid/RE=ABC_enhancer+EA_enhancer) dbVar:nssv15164761;dbVar:nssv15125831;dbVar:nssv15146713;dbVar:nssv15139036;dbVar:nssv15136993;dbVar:nssv15145871;dbVar:nssv15147378;dbVar:nssv15147960;dbVar:nssv15146962;dbVar:nssv15147414;dbVar:nssv15164765;dbVar:nssv15164764;dbVar:nssv15149091;dbVar:nssv15147291;dbVar:nssv15146993;dbVar:nssv15146992;dbVar:nssv15150844;dbVar:nssv17976838;dbVar:nssv15153658;dbVar:nssv15151111;nssv15151221 5:13649-180905029;5:22150-10308848;5:22150-15851485;5:22150-1659250;5:22150-2324057;5:22150-23607162;5:22150-28075213;5:22150-33418294;5:22150-34041255;5:22150-73708550;5:25329-180693344;5:25329-18698028;5:25329-19661628;5:50094-46115086;5:54955-35680947;5:54955-45649963;5:113577-20240392;5:113577-29310520;5:113577-35739404;5:113578-180719789 0.03;0.52;0.34;3.29;2.34;0.23;0.19;0.16;0.16;0.07;0.03;0.29;0.27;0.12;0.15;0.12;0.27;0.18;0.15;0.03 5p15 terminal (Cri du chat syndrome) region dbVar:nssv18330851;dbVar:nssv18841914;dbVar:nssv17649947;dbVar:nssv15147173;dbVar:nssv15145875;dbVar:nssv15147440;dbVar:nssv15146459;dbVar:nssv15146622;dbVar:nssv15147702;dbVar:nssv15136268;dbVar:nssv15146696;dbVar:nssv15145969;dbVar:nssv15151220;dbVar:nssv15132269;dbVar:nssv15148862;dbVar:nssv15148231;dbVar:nssv15147402;dbVar:nssv15146458;dbVar:nssv15149597;dbVar:nssv15147956;dbVar:nssv15148968;dbVar:nssv15148844;dbVar:nssv15146717;dbVar:nssv15148985;dbVar:nssv15148016;dbVar:nssv15148112;dbVar:nssv15145972;dbVar:nssv16866488;dbVar:nssv15140376;dbVar:nssv15148058;dbVar:nssv15148554;dbVar:nssv15132604;dbVar:nssv15134412;dbVar:nssv15147416;dbVar:nssv15140515;dbVar:nssv15135741;dbVar:nssv15141721;dbVar:nssv15138139;dbVar:nssv15139127;dbVar:nssv15139876;dbVar:nssv15134733;dbVar:nssv15142657;dbVar:nssv15141520;dbVar:nssv15147171;dbVar:nssv15150118;dbVar:nssv15146522;dbVar:nssv15164763;dbVar:nssv15150859;dbVar:nssv15166282;dbVar:nssv15132966;dbVar:nssv15132967;HI3:ISCA-37390;dbVar:nssv15146165;nssv15146815;dbVar:nssv15148064;dbVar:nssv15132680;dbVar:nssv15223218;dbVar:nssv15134417;dbVar:nssv16216549;dbVar:nssv15149121;dbVar:nssv15150161;dbVar:nssv15137858;dbVar:nssv15150229;dbVar:nssv15149886;dbVar:nssv16208009;dbVar:nssv17976839;dbVar:nssv15148942;dbVar:nssv16208008;dbVar:nssv15149911;dbVar:nssv15151402;dbVar:nssv15153655;dbVar:nssv15152885;dbVar:nssv15151403;dbVar:nssv18326313;dbVar:nssv15149508;dbVar:nssv16208007;dbVar:nssv15151241;dbVar:nssv15150601;dbVar:nssv15150625;dbVar:nssv17977082;dbVar:nssv15145995;dbVar:nssv15151861;dbVar:nssv16255066;dbVar:nssv16208006;dbVar:nssv16208011;dbVar:nssv15142295;dbVar:nssv16208010;dbVar:nssv15153656;dbVar:nssv15152886;dbVar:nssv15137538;dbVar:nssv15153657;dbVar:nssv17976724;dbVar:nssv15146000;dbVar:nssv17956677;dbVar:nssv18330187;dbVar:nssv18329119;dbVar:nssv18329189;dbVar:nssv15606071;dbVar:nssv15606072;dbVar:nssv16213555;dbVar:nssv16213990;dbVar:nssv18787102;dbVar:nssv18790308 5:2-32091038;5:10002-14320109;5:13201-4012072;5:22150-10044199;5:22150-11429370;5:22150-11530503;5:22150-12004203;5:22150-12820111;5:22150-13362684;5:22150-1429714;5:22150-16584684;5:22150-16930125;5:22150-17788806;5:22150-1826370;5:22150-21217229;5:22150-21726469;5:22150-22775404;5:22150-23132155;5:22150-24835567;5:22150-25699714;5:22150-26594000;5:22150-27188057;5:22150-27485726;5:22150-27611270;5:22150-27788723;5:22150-28429348;5:22150-28589299;5:22150-29048823;5:22150-2965987;5:22150-32248116;5:22150-34041196;5:22150-3404358;5:22150-3557056;5:22150-35831640;5:22150-4163847;5:22150-4260264;5:22150-4641409;5:22150-4833739;5:22150-5060009;5:22150-5102699;5:22150-6060215;5:22150-6112711;5:22150-6500967;5:22150-7213388;5:22150-9958240;5:22420-19281001;5:25329-18662625;5:25329-30672798;5:25329-31343671;5:37693-2747022;5:37693-2913319;5:37694-11347262;5:50094-15678560;5:50094-30112642;5:50094-4014761;5:52187-4163906;5:54955-5603514;5:71905-22078969;5:79147-15509107;5:79147-22152284;5:95244-5834664;5:113577-10163809;5:113577-10729838;5:113577-11767720;5:113577-12601027;5:113577-14684471;5:113577-14738180;5:113577-15291661;5:113577-15822225;5:113577-1708530;5:113577-1816055;5:113577-19167699;5:113577-2027194;5:113577-23047959;5:113577-23364376;5:113577-25091472;5:113577-26234903;5:113577-26948599;5:113577-30712376;5:113577-33998394;5:113577-4175855;5:113577-4305172;5:113577-4325585;5:113577-5194484;5:113577-5380741;5:113577-5657333;5:113577-5884399;5:113577-6125331;5:113577-6244090;5:113577-7946262;5:113577-8007018;5:113577-8876045;5:113578-16952167;5:113578-17654787;5:113578-26164852;5:113578-31448527;5:140475-26906925;5:140475-9792158;5:218462-1295161;5:218465-1297488;5:218472-1895829;5:482644-1895829 0.17;0.38;1.35;0.54;0.47;0.47;0.45;0.42;0.40;3.82;0.32;0.32;0.30;2.98;0.25;0.25;0.24;0.23;0.22;0.21;0.20;0.20;0.20;0.20;0.19;0.19;0.19;0.19;1.83;0.17;0.16;1.59;1.52;0.15;1.30;1.27;1.16;1.12;1.07;1.06;0.89;0.88;0.83;0.75;0.54;0.28;0.29;0.18;0.17;1.99;1.87;0.48;0.34;0.18;1.36;1.31;0.97;0.24;0.35;0.24;0.94;0.54;0.51;0.46;0.43;0.37;0.37;0.35;0.34;3.37;3.16;0.28;2.81;0.23;0.23;0.22;0.21;0.20;0.18;0.16;1.32;1.28;1.28;1.06;1.02;0.97;0.93;0.90;0.88;0.69;0.68;0.61;0.32;0.31;0.21;0.17;0.20;0.56;5.00;4.99;3.21;3.81 DDD:16279;DDD:16284;dbVar;dgv131e203 chr5:432151-919355;5:653582-875018;chr5:685856-850649;5:686604-840273;5:708603-865477 0.1231 DDD:16279;DDD:16284;dgv1000e199;dgv131e203 5:653582-875018;5:682475-788359;5:686604-840273;5:708603-865477 0.0497 IMH 5:238915-1591166;5:244073-1583559;5:244336-1583852;5:261961-1570436 0.2771 5:653582-875018 dgv131e203;5:686604-840273 DDD:16279;chr5:714350-736500 dbVar;5:714989-733938 1000g;5:714989-733938 1000g;5:717638-748444 DDD:16285;5:754104-754760 IMH;chr5:757676-778933 dbVar;5:757677-778933 1000g;5:757677-778933 dgv1062e214; chr5:432151-919355 dbVar;chr5:685856-850649 dbVar;5:708603-865477 DDD:16284;chr5:714988-733938 dbVar;5:714989-733938 1000g;5:714989-733938 dgv1061e214;chr5:732207-843089 dbVar;5:754156-754733 gnomAD-SV_v2.1_DUP_5_14078;5:757677-778933 1000g;5:757677-778933 1000g;5:763398-838450 DDD:16291 5:682475-788359 dgv1000e199;5:708603-865477 DDD:16284;5:714989-733938 1000g;chr5:724284-724491 dbVar;5:747151-776399 DDD:16288;chr5:757676-778933 dbVar;5:757677-778933 esv3603772;chr5:764454-764539 dbVar; 5:653582-875018 dgv131e203;5:686604-840273 DDD:16279;chr5:714988-733938 dbVar;5:714989-733938 esv3603766;chr5:725960-726319 dbVar;5:747846-753492 esv2673755;5:757677-778933 1000g;5:763398-838450 DDD:16291;chr5:774523-774617 dbVar 744527;685925;659292;744529;709867;697438;663622;778865;682015;665581;664429;653823;703782;663623;664430;663624;664431;654500;697439;673937;774010;654501;673938;673939 loss;gain 0.395 0.580 5:721917-723166 L1ME3F 5:686123-731394 5:770128-777143 98.37 0.535222227518795 -0.0274451648003615 8 3.6787e-13 4.3228e-02 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2L (ZDHHC11B, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 +5_723195_777000_DUP_1 5 723195 777000 53805 DUP Benign NA split p15.33 ZDHHC11B NM_001351303 2 710469 784844 53806 1058 94 yes 14 intron1-intron12 5'UTR-CDS 6214 3' 723194 777000 DDD:16279;DDD:16284;dbVar;dgv131e203 chr5:432151-919355;5:653582-875018;chr5:685856-850649;5:686604-840273;5:708603-865477 0.1231 DDD:16279;DDD:16284;dgv1000e199;dgv131e203 5:653582-875018;5:682475-788359;5:686604-840273;5:708603-865477 0.0497 IMH 5:238915-1591166;5:244073-1583559;5:244336-1583852;5:261961-1570436 0.2771 744527;685925;659292;744529;709867;697438;663622;778865;682015;665581;664429;653823;703782;663623;664430;663624;664431;654500;697439;673937;774010;654501;673938;673939 loss;gain 98.37 0.535222227518795 -0.0274451648003615 653082 8 3.6787e-13 4.3228e-02 full=3 +7_38296177_38352444_DEL_1 7 38296177 38352444 -56267 DEL Benign NA full p14.1 TARP STARD3NL TRG-AS1 1 SFRP4 (morbid/RE=ABC_enhancer);VPS41 (morbid/RE=ABC_enhancer) dbVar:nssv15777247;dbVar:nssv15168013;dbVar:nssv15161666;nssv15161679;dbVar:nssv15168014;dbVar:nssv15161726;dbVar:nssv15161869;dbVar:nssv17970205;dbVar:nssv15154527;dbVar:nssv15146465;dbVar:nssv15166972 7:10366-159119707;7:10705-159122532;7:43362-159119707;7:44936-159126310;7:54186-41915483;7:11048841-52863626;7:27507833-39072473;7:30463887-43470805;7:33367925-61831899;7:37213109-40255122 0.04;0.04;0.04;0.04;0.13;0.13;0.49;0.43;0.20;1.85 dbVar:nssv15161318;dbVar:nssv15147510;dbVar:nssv15148432;dbVar:nssv15147453;dbVar:nssv15145850;dbVar:nssv15148950 7:54186-159075079;7:32718004-41084581;7:32911004-44576005;7:35500387-42053399;7:37343083-48700334;7:38217602-45343699 0.04;0.67;0.48;0.86;0.50;0.79 dgv1888e212 7:38286516-38394857 0.0100 IMH 7:23891013-65526751;7:33013222-55782515 0.3810 7:38286516-38394857 dgv1888e212;chr7:38288427-38299834 dbVar;chr7:38292243-38299454 dbVar;chr7:38292598-38299075 dbVar;chr7:38292954-38305344 dbVar;chr7:38296039-38299834 dbVar;chr7:38300094-38304944 dbVar;chr7:38300094-38309816 dbVar;chr7:38301678-38304944 dbVar;chr7:38304944-38313034 dbVar;chr7:38305344-38309816 dbVar;chr7:38315596-38318010 dbVar;chr7:38315847-38318271 dbVar;chr7:38316099-38318010 dbVar 7:38283523-38309532 DDD:23873;chr7:38288205-38309816 dbVar;chr7:38292243-38297557 dbVar;chr7:38292243-38300094 dbVar;chr7:38292954-38297557 dbVar;chr7:38296039-38299075 dbVar;chr7:38299075-38299834 dbVar;chr7:38300094-38305344 dbVar;chr7:38301678-38302623 dbVar;chr7:38302623-38304944 dbVar;chr7:38305144-38312727 dbVar;chr7:38315596-38316099 dbVar;chr7:38315771-38317054 dbVar;chr7:38315946-38318532 dbVar chr7:38309816-38312727 dbVar;chr7:38312421-38313034 dbVar;chr7:38318010-38318532 dbVar;chr7:38321639-38325867 dbVar;chr7:38325667-38325867 dbVar;chr7:38325667-38328166 dbVar;chr7:38331989-38335441 dbVar;chr7:38331989-38336295 dbVar;chr7:38348388-38349972 dbVar chr7:38295995-38331222 dbVar;chr7:38309816-38313034 dbVar;chr7:38315910-38331224 dbVar;chr7:38321639-38325667 dbVar;chr7:38321639-38326916 dbVar;chr7:38325667-38327016 dbVar;chr7:38325867-38328166 dbVar;chr7:38331989-38335610 dbVar;chr7:38335441-38335779 dbVar 0.365 0.320 7:38296252-38296527 AluSx 7:38284220-38298557 0.0 1A (cf Gene_count, RE_gene, +0.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);2G (cf po_B_loss_someG_source, +0.00);3A (1 gene, +0.00);5F (+0.00) 3 +7_38296177_38352444_DEL_1 7 38296177 38352444 -56267 DEL Benign NA split p14.1 TARP NM_001003806 2 38299243 38313237 13994 336 100 no 4 txStart-txEnd 5'UTR-3'UTR 38299243 38313237 dgv1888e212 7:38286516-38394857 0.0100 dbVar chr7:38295995-38331222 0.01 IMH 7:23891013-65526751;7:33013222-55782515 0.3810 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA full p23.1 FAM66B;DEFB109B;USP17L1;USP17L4;ZNF705G;DEFB4B;DEFB103B;SPAG11B;DEFB104B;DEFB106B;DEFB105B;DEFB107B;PRR23D1;FAM90A7;FAM90A22;FAM90A23;FAM90A14;FAM90A18;FAM90A16;FAM90A8;FAM90A17;FAM90A19;FAM90A9;FAM90A10;PRR23D2;DEFB107A;DEFB105A;DEFB106A;DEFB104A;SPAG11A;DEFB103A;DEFB4A LINC00965 ZNF705B 32 MCPH1 (morbid/RE=ABC_enhancer+GH_promoter_enhancer) dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161508;dbVar:nssv15161747;dbVar:nssv17976867;dbVar:nssv17957391;dbVar:nssv15154583;dbVar:nssv15161801;nssv15777239;nssv17976962;dbVar:nssv15154584;dbVar:nssv16206921;dbVar:nssv15154580;dbVar:nssv15161417;nssv15161657;dbVar:nssv15147671;dbVar:nssv15161846;dbVar:nssv15150473;dbVar:nssv15127651;dbVar:nssv15149098;dbVar:nssv15169210;dbVar:nssv15154582;dbVar:nssv15146537;dbVar:nssv15161807;dbVar:nssv15161553;dbVar:nssv15161105;dbVar:nssv15161095;dbVar:nssv15161561;dbVar:nssv15161078;dbVar:nssv15147455;dbVar:nssv16736635;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161749;dbVar:nssv15143576;dbVar:nssv15161775;dbVar:nssv15146180;dbVar:nssv15161087;dbVar:nssv15161068;dbVar:nssv15161792;dbVar:nssv15606063;dbVar:nssv15151542;dbVar:nssv15161084;dbVar:nssv16206931;dbVar:nssv15154577;dbVar:nssv15161089;dbVar:nssv15151538;dbVar:nssv15152254;dbVar:nssv18842054;dbVar:nssv15161540;dbVar:nssv15161727;dbVar:nssv15161764 8:10214-146293414;8:13939-146304022;8:46311-11879315;8:46311-30472220;8:158049-10348413;8:158049-11936107;8:158049-13974319;8:158049-146295771;8:158049-15423270;8:158049-8102819;8:158049-9750676;8:158050-146295771;8:158992-13304906;8:158992-146280828;8:158992-17536147;8:163683-46938942;8:164985-11860845;8:164985-146293414;8:168484-13147575;8:169854-10022996;8:176453-12556063;8:176453-12570496;8:176453-146294098;8:176453-16137655;8:176453-34349408;8:176453-37879246;8:176453-7838959;8:176815-43396776;8:191531-146274835;8:191531-146280020;8:191531-17536206;8:191531-22404983;8:191531-23055911;8:191531-7752586;8:191606-146280167;8:191606-24514484;8:191606-30948590;8:194618-13947374;8:1825201-24533193;8:6961184-12157391;8:6999220-11895232;8:6999220-11898980;8:6999220-38553064;8:6999220-8881836;8:7053187-11805960;8:7080282-12045269;8:7169491-12404062;8:7268820-12039974;8:7691902-12039974 0.40;0.40;4.94;1.92;5.73;4.96;4.23;0.40;3.83;7.35;6.09;0.40;4.44;0.40;3.36;1.25;4.99;0.40;4.50;5.93;4.72;4.71;0.40;3.66;1.71;1.55;7.62;1.35;0.40;0.40;3.37;2.63;2.55;7.71;0.40;2.40;1.90;4.25;2.57;11.24;11.93;11.92;1.85;31.03;12.29;11.76;11.16;10.16;1.42 dbVar:nssv15168702;dbVar:nssv15169206;dbVar:nssv18842057;dbVar:nssv17956019;dbVar:nssv15154581;dbVar:nssv18326425;dbVar:nssv15149861;dbVar:nssv15775686;dbVar:nssv17976739;dbVar:nssv16208166;dbVar:nssv15774257;dbVar:nssv15149509;dbVar:nssv18330306;dbVar:nssv18329623;dbVar:nssv16216869;dbVar:nssv15169209;dbVar:nssv15223191;dbVar:nssv15147275;dbVar:nssv15148964;dbVar:nssv15147296;dbVar:nssv15146181;nssv15146816;dbVar:nssv15606064;dbVar:nssv15146660;dbVar:nssv18841910;dbVar:nssv15161264;nssv15161582;dbVar:nssv15145917;dbVar:nssv15161283;dbVar:nssv15161284;dbVar:nssv15161070;dbVar:nssv15141976;dbVar:nssv15161050 8:10214-10197718;8:10214-8948469;8:10502-11142629;8:10502-7214947;8:158049-10939681;8:158049-11281408;8:158049-13309069;8:158049-14214722;8:158049-30187456;8:158049-9025197;8:158049-9393052;8:158049-9749574;8:158050-10965627;8:158050-18936715;8:161517-11516619;8:164985-10007227;8:176815-7753583;8:191531-10049105;8:191531-10315994;8:191531-10724642;8:191531-7752586;8:194618-7787444;8:360370-7334625;8:399894-23712417;8:2292236-27361796;8:3791728-11384448;8:7053187-12241152;8:7092360-12372324;8:7169491-12404062;8:7268820-11805960;8:7268820-11819316 5.73;6.53;5.25;0.63;5.42;5.25;4.44;4.16;1.95;6.59;6.32;6.09;5.40;3.11;5.14;5.93;7.71;5.93;5.77;5.55;7.71;7.69;2.37;2.51;2.33;7.69;11.26;11.06;11.16;10.68;10.65 DDD:26674;TS40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 8:6858816-8072303 esv2761169;8:6985776-7230992 DDD:26670;8:7035907-7428513 DDD:26675;8:7154889-7213289 DDD:26682;chr8:7159226-7201223 dbVar;8:7170611-7177489 nsv515099;chr8:7190000-7195000 dbVar;8:7201176-7392220 DDD:26689;chr8:7212582-7227421 dbVar;8:7212583-7227421 1000g;8:7212583-7227421 TS40:ISCA-46631;8:7241528-7403182 nsv515100;8:7250369-7832042 dgv6936n100;8:7283000-7289250 gnomAD-SV_v2.1_DUP_8_23698;8:7335400-7408600 gnomAD-SV_v2.1_DUP_8_23699;chr8:7365000-7404400 dbVar;8:7393000-7403950 gnomAD-SV_v2.1_DUP_8_23701;chr8:7403133-7474073 dbVar;chr8:7424800-7474000 dbVar;chr8:7525167-7866528 dbVar;chr8:7532000-7545000 dbVar... chr8:6828277-7474073 dbVar;8:6959834-8600711 esv2764098;8:7024892-8031414 DDD:26674;8:7053187-8130689 TS40:ISCA-37472;chr8:7159226-7187516 dbVar;chr8:7159226-7474073 dbVar;chr8:7187516-7201223 dbVar;8:7190891-7190961 DDD:26685;chr8:7206400-7253000 dbVar;8:7212583-7227421 1000g;8:7212583-7227421 1000g;8:7212583-7227421 dgv1365e214;chr8:7243000-7356000 dbVar;8:7273500-7474150 gnomAD-SV_v2.1_DUP_8_23697;8:7308244-7308706 DDD:26704;chr8:7355000-7365050 dbVar;8:7374000-7380000 gnomAD-SV_v2.1_DUP_8_23700;8:7401394-7472190 DDD:26720;chr8:7404000-7437650 dbVar;chr8:7525167-7633135 dbVar;chr8:7525167-8097772 dbVar... 8:6959834-8600711 esv2764098;8:7024892-8031414 DDD:26674;8:7053187-8130689 HI40:ISCA-37472;8:7154889-7213289 DDD:26682;8:7158202-7189800 DDD:26683;chr8:7179582-7191032 dbVar;8:7179583-7191032 esv3616115;8:7190891-7190961 DDD:26685;chr8:7201000-7206400 dbVar;chr8:7204184-7204308 dbVar;8:7212583-7227421 1000g;chr8:7221359-7221602 dbVar;8:7228000-7235000 gnomAD-SV_v2.1_DEL_8_89335;chr8:7286205-7286328 dbVar;chr8:7326402-7326559 dbVar;8:7355000-7363000 gnomAD-SV_v2.1_DEL_8_89340;8:7355294-7364762 1000g;8:7401394-7472190 DDD:26720;8:7402900-7419700 gnomAD-SV_v2.1_DEL_8_89341;8:7405950-7443050 gnomAD-SV_v2.1_DEL_8_89342;8:7417000-7425000 gnomAD-SV_v2.1_DEL_8_89343... 8:6858816-8072303 esv2761169;8:6985776-7230992 DDD:26670;8:7035907-7428513 DDD:26675;chr8:7085462-7537934 dbVar;8:7158046-7189992 esv2675221;chr8:7175745-7175870 dbVar;8:7179583-7191032 1000g;chr8:7180382-7180743 dbVar;8:7190892-7196288 DDD:26687;8:7201000-7206400 gnomAD-SV_v2.1_DEL_8_89332;chr8:7212582-7227421 dbVar;8:7212583-7227421 esv3616116;chr8:7228000-7235000 dbVar;chr8:7276552-7277128 dbVar;8:7308244-7308706 DDD:26704;chr8:7355000-7363000 dbVar;chr8:7355293-7364762 dbVar;8:7355294-7364762 esv3616120;chr8:7402900-7419700 dbVar;chr8:7405950-7443050 dbVar;chr8:7417000-7425000 dbVar... 674618;1021421;1021422;646653;1520679;1915732;3052323;2599287;832406;665154;653853;679166;678976;663306;700319;654990;679312;646920;863772;653647;649616;671308;658988;675704;1023557;678564;857770;745967;654991;676140;783310;824013;870858;820152;834536;871873;875246;654992;701040;665155;745968;682446;745969;702113;890458;732002;921361;909011;880183;1018294;925302;... loss;gain 0.260 0.330 8:7150797-7184572;8:7150797-7195814;8:7150797-7200543;8:7150798-7238459 8:7600001-7825413 8:7012601-8066200 High Signal Region 8:7012601-8066200 High Signal Region 99.72 2.14121257165536 2.19863945242443 8 4.2180e-01 5.1947e-01 -0.55 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3B (32 genes, +0.45);5F (+0.00) 3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM66B NR_027423 2 7156265 7212885 43395 0 0 no 7 txStart-intron6 UTR 9797 3' 7169490 7212885 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7474073 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289 0.2237 100128890 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB109B NM_001037380 2 7170243 7177618 7375 264 100 no 2 txStart-txEnd 5'UTR-3'UTR 7170243 7177618 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7187516;chr8:7159226-7201223;chr8:7159226-7474073 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26683;HI40:ISCA-37472;dbVar;esv2675221;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289;8:7158046-7189992;8:7158202-7189800 0.2237 641517 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 USP17L1 NM_001256873 1 7189908 7191501 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7189908 7191501 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7201223;chr8:7159226-7474073;chr8:7187516-7201223 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289 0.2237 401447 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 USP17L4 NM_001256874 1 7194636 7196229 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7194636 7196229 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7201223;chr8:7159226-7474073;chr8:7187516-7201223 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26687;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289;8:7190892-7196288 0.2237 645402 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 ZNF705G NM_001164457 3 7213038 7243080 30042 903 100 no 7 txStart-txEnd 5'UTR-3'UTR 7213038 7243080 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;chr8:7206400-7253000 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 1023557;745967;654991;676140;745968;732002 loss;gain 91.1 -1.59751875296103 -3.97736276921453 100131980 9 1.6471e-08 4.2486e-09 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB4B NM_001205266 2 7272376 7274385 2009 195 100 no 2 txStart-txEnd 5'UTR-3'UTR 7272376 7274385 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 99.72 100289462 9 6.7977e-02 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB103B NM_018661 4 7286409 7287870 1461 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7286409 7287870 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23698;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150;8:7283000-7289250 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 85.97 55894 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 SPAG11B NM_058201 4 7308124 7321064 12940 402 100 no 3 txStart-txEnd 5'UTR-3'UTR 7308124 7321064 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 89.4 2.14121257165536 1.8677219993927 10407 9 2.7751e-02 4.7238e-02 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB104B NM_001040702 1 7327829 7332604 4775 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7327829 7332604 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 95.66 503618 9 3.3176e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB106B NM_001040704 2 7340025 7343922 3897 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7340025 7343922 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 93.29 503841 9 8.1151e-02 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB105B NM_001040703 3 7345200 7347115 1915 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7345200 7347115 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 90.95 504180 9 2.9184e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB107B NM_001040705 2 7353432 7366833 13401 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7353432 7366833 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 603719;849088;921364 gain 91.71 503614 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 PRR23D1 NM_001282479 1 7397148 7399972 2824 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7397148 7399972 DDD:26674;DDD:26675;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;gnomAD-SV_v2.1_DUP_8_23701;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;chr8:7365000-7404400;8:7393000-7403950 0.5625 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 100131608 8 4.2180e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A7 NM_001397387 1 7414221 7417234 3013 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7414221 7417234 DDD:26674;DDD:26675;DDD:26720;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7250369-7832042;8:7273500-7474150;8:7401394-7472190;chr8:7403133-7474073;chr8:7404000-7437650 0.2355 DDD:26674;DDD:26675;DDD:26720;HI40:ISCA-37472;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89341;gnomAD-SV_v2.1_DEL_8_89342 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7401394-7472190;chr8:7402900-7419700;8:7402900-7419700;chr8:7405950-7443050;8:7405950-7443050 0.5803 441317 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A22 NM_001397382 1 7429516 7432528 3012 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7429516 7432528 DDD:26674;DDD:26720;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7159226-7474073;8:7250369-7832042;8:7273500-7474150;8:7401394-7472190;chr8:7403133-7474073;chr8:7404000-7437650;chr8:7424800-7474000 0.2355 DDD:26674;DDD:26720;HI40:ISCA-37472;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89342 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7085462-7537934;8:7401394-7472190;chr8:7405950-7443050;8:7405950-7443050 0.4842 645558 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A23 NM_001397380 1 7437165 7440175 3010 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7437165 7440175 DDD:26674;DDD:26720;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7159226-7474073;8:7250369-7832042;8:7273500-7474150;8:7401394-7472190;chr8:7403133-7474073;chr8:7424800-7474000 0.2355 DDD:26674;DDD:26720;HI40:ISCA-37472;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89342 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7085462-7537934;8:7401394-7472190;chr8:7405950-7443050;8:7405950-7443050 0.4842 645572 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A14 NM_001164452 1 7572964 7575975 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7572964 7575975 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23703 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;8:7570000-7579000 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 645651 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A18 NM_001164451 1 7580612 7583623 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7580612 7583623 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441326 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A16 NM_001397396 1 7588260 7591271 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7588260 7591271 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441323 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A8 NM_001164450 1 7595908 7598918 3010 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7595908 7598918 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441324 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A17 NM_001397391 1 7603555 7606566 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7603555 7606566 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 728746 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A19 NM_001164449 1 7611203 7614214 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7611203 7614214 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700;chr8:7608000-7649500 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 728753 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A9 NM_001164448 1 7618851 7621862 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7618851 7621862 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700;chr8:7608000-7649500 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441327 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 FAM90A10 NM_001164447 1 7626498 7629510 3012 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7626498 7629510 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7608000-7649500 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441328 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 PRR23D2 NM_001282478 1 7636112 7638935 2823 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7636112 7638935 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7608000-7649500;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 100133251 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB107A NM_001037668 1 7669241 7673238 3997 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7669241 7673238 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 682133 gain 92.48 245910 9 3.2633e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB105A NM_152250 3 7678525 7681402 2877 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7678525 7681402 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23704;gnomAD-SV_v2.1_DUP_8_23705 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7671000-7682600;8:7671000-7687000 0.2648 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 90.61 0.918523398770926 0.00809335391872301 245908 8 3.7719e-01 4.3625e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB106A NM_152251 4 7682660 7686575 3915 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7682660 7686575 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23705 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7671000-7687000 0.2648 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 90.45 0.676417083229402 1.6332400949348 245909 9 8.5821e-03 4.0931e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB104A NM_080389 3 7693957 7698764 4807 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7693957 7698764 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 96.98 1.33624136747443 2.19863945242443 140596 9 9.3748e-02 5.1947e-01 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 SPAG11A NM_001395484 1 7705529 7718465 12936 402 100 no 3 txStart-txEnd 5'UTR-3'UTR 7705529 7718465 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 97.15 0.140072348156658 0.903069021299127 653423 9 6.9645e-05 3.9012e-02 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB103A NM_001081551 4 7738913 7740185 1272 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7738913 7740185 DDD:26674;DDD:26727;DDD:26729;DDD:26742;DDD:26743;TS40:ISCA-37472;TS40:ISCA-46381;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23708 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7718891-7784263;8:7734213-7856702;8:7737000-7743100;chr8:7737000-7743100;8:7737000-7743100 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;HI40:ISCA-46380;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89353 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630;8:7736500-7764500;chr8:7736500-7764500;8:7736500-7764500 0.3262 93.4 414325 full=3 +8_7169491_7753583_DEL_1 8 7169491 7753583 -584092 DEL Benign NA split p23.1 DEFB4A NM_004942 4 7752198 7754238 1385 58 29 yes 2 txStart-intron1 5'UTR-CDS 412 3' 7752198 7753583 DDD:26674;DDD:26727;DDD:26729;DDD:26742;DDD:26743;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7718891-7784263;8:7734213-7856702 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;HI40:ISCA-46380;HI40:ISCA-46382;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89353;gnomAD-SV_v2.1_DEL_8_89355 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630;8:7736500-7764500;chr8:7736500-7764500;8:7736500-7764500;8:7745000-7754100;chr8:7745000-7754100;8:7745000-7754100 0.5182 97.87 1.12959151611996 0.758429673080804 1673 9 1.1637e-03 3.9981e-01 full=3 +1_149041934_149209289_DEL_1 1 149041934 149209289 -167355 DEL Benign NA full q21.2 RNVU1-17 LSP1P5 RNVU1-18 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv18842007;dbVar:nssv15140065;dbVar:nssv15127264;dbVar:nssv15140622;dbVar:nssv15142143;dbVar:nssv15139736;dbVar:nssv15136257;dbVar:nssv15137789;dbVar:nssv15135435;dbVar:nssv15132352;dbVar:nssv15127572;dbVar:nssv16736643;dbVar:nssv15135787;dbVar:nssv15121048;dbVar:nssv15132855 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:142535936-157648813;1:143500224-149763815;1:143544036-149754161;1:143753741-151399970;1:143932351-149801420;1:144927579-153223600;1:145425396-149091187;1:145425396-149699420;1:145425396-149768855;1:145451330-156102366;1:145764500-249233096;1:145818703-149378266;1:146500973-149433185;1:147400638-149813625;1:147411535-149699420 0.07;0.07;0.07;1.11;2.67;2.69;2.19;2.85;2.02;1.34;3.92;3.85;1.57;0.16;4.70;5.71;6.94;7.31 dbVar:nssv15132982;dbVar:nssv15133379;dbVar:nssv15137633;dbVar:nssv15137132;dbVar:nssv15136850;dbVar:nssv15132445;dbVar:nssv15137470;dbVar:nssv15135169;dbVar:nssv15129680;dbVar:nssv15157514;dbVar:nssv15133691;dbVar:nssv15132524;dbVar:nssv15137778 1:143721527-149232481;1:145388356-149418924;1:145415157-149433207;1:145626238-149244468;1:145626238-149453964;1:145655993-149232481;1:145747243-149155026;1:145987157-149232481;1:146053395-249233096;1:146089269-149376652;1:146143190-149232481;1:146143190-149699420;1:146507650-149433207 3.04;4.15;4.17;4.63;4.37;4.68;3.32;5.16;0.16;5.09;5.42;4.71;5.72 DDD:2784;DDD:2806;TS40:ISCA-37469;dbVar;dgv4e203;nsv514006 1:147929337-149801433;1:148050780-149739249;1:148867552-149768855;1:149034710-149405578;chr1:149035900-149459350;1:149036513-149244464 0.0800 DDD:2784;DDD:2806;HI40:ISCA-37469;dgv375n100;dgv4e203;esv2422083;esv3894145 1:147929337-149801433;1:148050780-149739249;1:148867552-149768855;1:149034710-149405578;1:149036513-149278459;1:149036525-149256691;1:149039121-149211496 0.3041 IMH 1:4599855-170869838;1:17124869-234920285;1:17225077-149220997;1:17229845-149217063;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.4999 1:148050780-149739249 DDD:2784;1:149034710-149405578 DDD:2806;1:149036513-149244464 nsv514006;chr1:149068307-149095518 dbVar;chr1:149071634-149169501 dbVar;1:149071635-149169501 esv3587467;chr1:149093107-149137677 dbVar;chr1:149117907-149137677 dbVar;chr1:149138701-149141704 dbVar;chr1:149144314-149151529 dbVar;chr1:149151838-149203736 dbVar;1:149151839-149203736 esv3587470;1:149207861-149218152 1000g; 1:147929337-149801433 dgv4e203;1:148867552-149768855 TS40:ISCA-37469;chr1:149035900-149459350 dbVar;chr1:149037005-149068307 dbVar;chr1:149068307-149114963 dbVar;1:149071635-149169501 1000g;chr1:149081912-149105240 dbVar;chr1:149095518-149114963 dbVar;chr1:149117907-149138701 dbVar;chr1:149138701-149144314 dbVar;chr1:149144314-149215452 dbVar;1:149151839-149203736 1000g;chr1:149207860-149218152 dbVar;1:149207861-149218152 esv3587472 1:148050780-149739249 DDD:2784;1:149034710-149405578 DDD:2806;1:149035900-149053900 gnomAD-SV_v2.1_DEL_1_7834;1:149035900-149204000 gnomAD-SV_v2.1_DEL_1_7835;1:149036525-149256691 esv2422083;chr1:149046220-149046341 dbVar;1:149064634-149080509 gnomAD-SV_v2.1_DEL_1_7837;chr1:149071634-149169501 dbVar;1:149071635-149169501 esv3587466;chr1:149090849-149092378 dbVar;1:149090850-149092378 esv3587468;chr1:149132411-149132504 dbVar;chr1:149134000-149204000 dbVar;chr1:149139251-149139476 dbVar;chr1:149151838-149203736 dbVar;1:149151839-149203736 esv3587469;chr1:149156359-149156429 dbVar;chr1:149159117-149159254 dbVar;chr1:149173738-149173810 dbVar;1:149202746-149436842 DDD:2817;chr1:149207860-149218152 dbVar... 1:147929337-149801433 dgv4e203;1:148867552-149768855 HI40:ISCA-37469;chr1:149035900-149053900 dbVar;chr1:149035900-149204000 dbVar;1:149036513-149278459 dgv375n100;1:149039121-149211496 esv3894145;chr1:149064634-149080509 dbVar;chr1:149065069-149065232 dbVar;1:149071635-149169501 1000g;chr1:149077419-149077503 dbVar;1:149090850-149092378 1000g;chr1:149132411-149132463 dbVar;chr1:149133674-149133762 dbVar;1:149134000-149204000 gnomAD-SV_v2.1_DEL_1_7844;1:149145234-149244654 DDD:2814;1:149151839-149203736 1000g;1:149152065-149204067 HI40:ISCA-46570;chr1:149158275-149158337 dbVar;chr1:149162118-149162210 dbVar;chr1:149191596-149191654 dbVar;1:149207852-149218151 HI40:ISCA-46571... 0.455 0.440 1:149209192-149209220 (GA)n 1:149035966-149106186 1:149191324-149214601;1:149200001-149214601 1:147832001-149058800 High Signal Region -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +1_149041934_149209289_DEL_1 1 149041934 149209289 -167355 DEL Benign NA split q21.2 RNVU1-17 NR_104078 1 149194105 149194269 164 0 0 no 1 txStart-txEnd UTR 149194105 149194269 1000g;DDD:2784;DDD:2806;TS40:ISCA-37469;dbVar;dgv4e203;esv3587470;nsv514006 1:147929337-149801433;1:148050780-149739249;1:148867552-149768855;1:149034710-149405578;chr1:149035900-149459350;1:149036513-149244464;chr1:149144314-149215452;chr1:149151838-149203736;1:149151839-149203736;1:149151839-149203736 0.0800 1000g;DDD:2784;DDD:2806;DDD:2814;HI40:ISCA-37469;HI40:ISCA-46570;dbVar;dgv375n100;dgv4e203;esv2422083;esv3587469;esv3894145;gnomAD-SV_v2.1_DEL_1_7835;gnomAD-SV_v2.1_DEL_1_7844 1:147929337-149801433;1:148050780-149739249;1:148867552-149768855;1:149034710-149405578;chr1:149035900-149204000;1:149035900-149204000;1:149036513-149278459;1:149036525-149256691;1:149039121-149211496;chr1:149134000-149204000;1:149134000-149204000;1:149145234-149244654;chr1:149151838-149203736;1:149151839-149203736;1:149151839-149203736;1:149152065-149204067 0.3041 IMH 1:4599855-170869838;1:17124869-234920285;1:17225077-149220997;1:17229845-149217063;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.4999 101954269 full=1 +1_248738899_248785562_DEL_1 1 248738899 248785562 -46663 DEL Benign NA full q44 OR2T10 OR2T34 OR2T11 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15777262;dbVar:nssv15151024;dbVar:nssv18326443;dbVar:nssv16207620;dbVar:nssv15146793;dbVar:nssv15147003;dbVar:nssv15146656;dbVar:nssv16215284;dbVar:nssv15145669;dbVar:nssv15154064;dbVar:nssv15146178;dbVar:nssv18329268;dbVar:nssv15147314;dbVar:nssv15147005;dbVar:nssv15146390;dbVar:nssv15150211;dbVar:nssv15147383;dbVar:nssv15146391;dbVar:nssv15126459;dbVar:nssv15146018;dbVar:nssv15156411;dbVar:nssv15147341;dbVar:nssv15149590;dbVar:nssv15170725;dbVar:nssv15149119;dbVar:nssv15774642;dbVar:nssv15776729;dbVar:nssv15145719;dbVar:nssv15142850;dbVar:nssv15140102;dbVar:nssv15119915;dbVar:nssv15135164;dbVar:nssv18330767;dbVar:nssv15142418;dbVar:nssv15133070;dbVar:nssv15128248;dbVar:nssv18326380 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:182388774-249111240;1:195483440-249213000;1:197867915-249224684;1:204045949-249218992;1:207519988-249224684;1:209819553-249225312;1:210136971-249212668;1:210152795-249218992;1:214197156-249212668;1:218252552-249224684;1:223521036-249212668;1:223972940-249224684;1:224002850-249212668;1:224016203-249185508;1:224075483-249185508;1:224105295-249224684;1:224210565-249212668;1:224284191-249212668;1:225049988-249233096;1:225626183-249060210;1:228529974-249181598;1:229158657-249212668;1:231670871-249213000;1:232232336-249218992;1:234050865-249213059;1:235582581-249224684;1:238669294-249224684;1:240407745-249185508;1:242324399-249224684;1:242656461-249213000;1:242992034-249185508;1:243095879-249158835;1:243258051-249224684;1:244197792-249224684;1:245476118-249212668;1:245665464-249233096;1:246850402-249205263 0.02;0.02;0.02;0.05;0.07;0.09;0.09;0.10;0.11;0.12;0.12;0.12;0.13;0.15;0.18;0.18;0.19;0.19;0.19;0.19;0.19;0.19;0.19;0.20;0.23;0.23;0.27;0.27;0.31;0.34;0.44;0.53;0.68;0.71;0.75;0.77;0.78;0.93;1.25;1.31;1.98 dbVar:nssv15129680;dbVar:nssv18326340;dbVar:nssv15149874;dbVar:nssv15148823;dbVar:nssv15148210;dbVar:nssv15148138;dbVar:nssv15148243;dbVar:nssv15146635;dbVar:nssv15146644;dbVar:nssv15146499;dbVar:nssv15146500;dbVar:nssv18330244;dbVar:nssv15145856;dbVar:nssv15153348;dbVar:nssv15146579;dbVar:nssv15131783;dbVar:nssv18329412;dbVar:nssv15138053;dbVar:nssv15124424;dbVar:nssv18841999;dbVar:nssv15126240;dbVar:nssv15133004;dbVar:nssv15771899;dbVar:nssv15133645;dbVar:nssv15153353;dbVar:nssv15605763;dbVar:nssv18792785;dbVar:nssv15772690;dbVar:nssv16255440 1:146053395-249233096;1:233012995-249206918;1:235797385-249224684;1:236719383-249212668;1:237806582-249212668;1:238196876-249218733;1:238356181-249224684;1:238514422-249212668;1:238917050-249212666;1:239721731-249212668;1:239793169-249218792;1:239910961-249224684;1:240628423-249212668;1:241051171-249224684;1:241210723-249218792;1:241920552-249185508;1:242045198-249212668;1:242208582-249224684;1:243103402-249119318;1:243384761-249213309;1:243477621-249233096;1:243949932-249212668;1:244379482-249224684;1:244745426-249212668;1:244797640-249224684;1:245341154-249212429;1:245704070-249212562;1:246565045-249224684;1:246853200-249181899 0.05;0.29;0.35;0.37;0.41;0.42;0.43;0.44;0.45;0.49;0.50;0.50;0.54;0.57;0.58;0.64;0.65;0.67;0.78;0.80;0.81;0.89;0.96;1.04;1.05;1.21;1.33;1.75;2.00 dbVar chr1:248070033-248787097;chr1:248502721-248875715;chr1:248720994-248795675 0.01 DDD:4636;DDD:4639;HI40:ISCA-46339;dbVar;dgv166e212;dgv630n100;esv2760083;esv2763780;gnomAD-SV_v2.1_DEL_1_13889 1:248605753-248818483;1:248683401-248814080;1:248688222-248828223;1:248693963-248856466;1:248727631-248859425;1:248731000-248798200;chr1:248731000-248798200;1:248731000-248798200;1:248737436-248818471 0.2767 IMH 1:248596196-248822398;1:248601499-248817009;1:248601686-248817033;1:248602851-248816084;1:248606626-248811646;1:248609654-248808661 0.4394 chr1:248502721-248875715 dbVar;chr1:248720994-248795675 dbVar;chr1:248745821-248849502 dbVar;1:248756742-248797597 1000g chr1:248070033-248787097 dbVar;chr1:248560944-248756386 dbVar;chr1:248745821-248795675 dbVar;chr1:248756741-248797597 dbVar 1:248605753-248818483 esv2760083;1:248688222-248828223 dgv166e212;1:248712455-248757403 HI40:ISCA-46337;1:248712455-248757403 gnomAD-SV_v2.1_DEL_1_13885;1:248729000-248743000 HI40:ISCA-46338;1:248729000-248743000 gnomAD-SV_v2.1_DEL_1_13888;chr1:248731000-248798200 dbVar;1:248737436-248818471 dgv630n100;chr1:248738000-248744000 dbVar;1:248739346-248798392 esv2660478;1:248739502-248798200 DDD:4645;chr1:248741000-248749000 dbVar;chr1:248742276-248742334 dbVar;1:248753185-248795277 dgv167e212;chr1:248755655-248758478 dbVar;1:248755656-248758478 HI40:ISCA-46577;1:248755670-248758483 DDD:4648;chr1:248756741-248797597 dbVar;1:248756742-248797597 esv3589559; chr1:248469040-248768529 dbVar;1:248683401-248814080 esv2763780;1:248693963-248856466 DDD:4636;chr1:248712455-248757403 dbVar;1:248727631-248859425 DDD:4639;chr1:248729000-248743000 dbVar;1:248731000-248798200 HI40:ISCA-46339;1:248731000-248798200 gnomAD-SV_v2.1_DEL_1_13889;1:248738000-248744000 HI40:ISCA-46340;1:248738000-248744000 gnomAD-SV_v2.1_DEL_1_13890;chr1:248739419-248739472 dbVar;1:248739517-248797213 esv2421359;1:248741000-248749000 gnomAD-SV_v2.1_DEL_1_13892;1:248749183-248797201 dgv633n100;1:248753986-248795457 nsv514048;1:248755656-248758478 1000g;1:248755656-248758478 esv3589558;chr1:248755674-248758483 dbVar;1:248756742-248797597 1000g;1:248756881-248797809 HI40:ISCA-46576 864662 loss 0.305 0.330 1:248692097-248751707 92.08 0.553342166544692 -0.565086620797697 9 6.5559e-04 1.5575e-04 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +1_248738899_248785562_DEL_1 1 248738899 248785562 -46663 DEL Benign NA split q44 OR2T10 NM_001004693 2 248753787 248761001 7214 939 97 no 2 txStart-txEnd 5'UTR-3'UTR 248753787 248761001 dbVar chr1:248070033-248787097;chr1:248502721-248875715;chr1:248720994-248795675;chr1:248745821-248795675;chr1:248745821-248849502 0.01 DDD:4636;DDD:4639;DDD:4645;HI40:ISCA-46339;dbVar;dgv166e212;dgv167e212;dgv630n100;dgv633n100;esv2421359;esv2660478;esv2760083;esv2763780;gnomAD-SV_v2.1_DEL_1_13889 chr1:248469040-248768529;1:248605753-248818483;1:248683401-248814080;1:248688222-248828223;1:248693963-248856466;1:248727631-248859425;1:248731000-248798200;chr1:248731000-248798200;1:248731000-248798200;1:248737436-248818471;1:248739346-248798392;1:248739502-248798200;1:248739517-248797213;1:248749183-248797201;1:248753185-248795277 0.2767 IMH 1:248596196-248822398;1:248601499-248817009;1:248601686-248817033;1:248602851-248816084;1:248606626-248811646;1:248609654-248808661 0.4394 92.08 0.553342166544692 -0.565086620797697 127069 9 6.5559e-04 1.5575e-04 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA full q11.22 GPRIN2;NPY4R;LINC00842;HNRNPA1P33;ANXA8L1;FAM25BP;AGAP14P;SHLD2P3;ANTXRLP1 SYT15 LOC105378577 9 GDF2 (morbid/RE=ABC_enhancer) dbVar:nssv15171419;dbVar:nssv15161644;dbVar:nssv15171420;dbVar:nssv15161671;dbVar:nssv15161670;nssv15161864;dbVar:nssv18830975;dbVar:nssv15148987;dbVar:nssv15146649;dbVar:nssv15148014;dbVar:nssv15147999;dbVar:nssv15127252;dbVar:nssv15149138;dbVar:nssv15160810;dbVar:nssv15153822;dbVar:nssv18329611;dbVar:nssv15157044;dbVar:nssv15774462 10:73233-135524321;10:93298-135378918;10:98088-135477883;10:100027-50961640;10:100028-135427143;10:11138693-135427143;10:42607636-69160433;10:42890650-52636819;10:43180755-75475666;10:43379743-54025077;10:43957497-55681185;10:46242058-51595050;10:46591858-51028871;10:46966534-51822386;10:46966535-51903756;10:47049548-51903662;10:47148814-51626260 0.45;0.45;0.45;1.21;0.45;0.49;2.32;6.31;1.90;5.78;5.24;11.49;13.86;12.66;12.45;11.15;9.88 dbVar:nssv18830989;dbVar:nssv18792766;dbVar:nssv15148974;dbVar:nssv15147055;dbVar:nssv15147325;dbVar:nssv15149769;dbVar:nssv15153824;dbVar:nssv15775323;dbVar:nssv18330284;dbVar:nssv18842061;dbVar:nssv18326311;dbVar:nssv15152293;dbVar:nssv15147381;dbVar:nssv15149118;dbVar:nssv15148000;dbVar:nssv15148874;dbVar:nssv15605856;dbVar:nssv17976988;dbVar:nssv16252224;dbVar:nssv15153821;dbVar:nssv15155360;dbVar:nssv15153823;nssv15775280;dbVar:nssv15149894;dbVar:nssv18330270;dbVar:nssv15151095;dbVar:nssv15150620;dbVar:nssv16596271;dbVar:nssv16254627 10:12829207-135427143;10:46200157-51028871;10:46205691-51330432;10:46205691-51911085;10:46205697-51724915;10:46224447-51594991;10:46225365-51874356;10:46235358-51874163;10:46269494-51874356;10:46284270-51870080;10:46287822-51627470;10:46287822-51861565;10:46476966-51724915;10:46491170-51081560;10:46491170-51594991;10:46491170-51664079;10:46544811-51743471;10:46576516-51680164;10:46964974-51826226;10:46966534-51700837;10:46966534-51874356;10:46966534-51903755;10:46966534-51903756;10:46966535-51700837;10:46966535-51822386;10:46966535-51903756;10:46966536-51874356;10:47132306-51627470 0.50;12.73;12.00;10.78;11.14;11.45;10.88;10.90;10.97;11.01;11.51;11.03;11.72;13.39;12.05;11.89;11.83;12.05;12.65;12.99;12.53;12.45;12.45;12.99;12.66;12.45;12.53;10.20 DDD:32922;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:46966535-48298893 0.1100 DDD:32922;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094 0.0260 IMH 10:46257220-51811936 0.0179 10:46416327-47756284 DDD:32922;10:46931463-47389066 DDD:32936;10:46943378-47136996 dgv22e55;10:46966535-48298893 dgv221e212;10:46976293-47023561 1000g;10:46976293-47023561 1000g;chr10:47007970-47086710 dbVar;10:47007971-47086710 1000g;10:47007971-47086710 dgv117e214;chr10:47089972-47150813 dbVar;10:47089973-47150813 1000g;10:47089973-47150813 dgv118e214;chr10:47132970-47134018 dbVar;10:47148500-47181050 gnomAD-SV_v2.1_DUP_10_29720;10:47150450-47160300 gnomAD-SV_v2.1_DUP_10_29721;chr10:47216500-47271200 dbVar;chr10:47321000-47396000 dbVar;chr10:47332750-47373000 dbVar;10:47370500-47380000 gnomAD-SV_v2.1_DUP_10_29725;chr10:47383857-47395064 dbVar;10:47383858-47395064 1000g... 10:46109534-48312291 nsv516485;10:46923704-47138897 DDD:32934;10:46931470-47201116 DDD:32937;10:46943378-47742094 dgv24e55;chr10:46976292-47023561 dbVar;10:46976293-47023561 1000g;10:46976293-47023561 dgv116e214;10:47007971-47086710 1000g;10:47007971-47086710 1000g;chr10:47048634-47429105 dbVar;10:47089973-47150813 1000g;10:47089973-47150813 1000g;chr10:47122885-47123070 dbVar;chr10:47142102-47170473 dbVar;chr10:47150450-47160300 dbVar;chr10:47208000-47303000 dbVar;chr10:47308000-47315100 dbVar;10:47321000-47396000 gnomAD-SV_v2.1_DUP_10_29724;chr10:47370500-47380000 dbVar;chr10:47371250-47401275 dbVar;10:47383858-47395064 1000g... 10:46416327-47756284 DDD:32922;10:46943378-47742094 dgv23e55;chr10:47009185-47009299 dbVar;10:47036095-47036306 IMH;chr10:47083158-47083218 dbVar;10:47083161-47083233 gnomAD-SV_v2.1_DEL_10_109994;chr10:47088385-47088703 dbVar;chr10:47120109-47120186 dbVar;chr10:47148773-47150391 dbVar;10:47148774-47150391 esv3623121;10:47172000-47177000 HI40:ISCA-46432;10:47177700-47182800 HI40:ISCA-46433;10:47191200-47201400 HI40:ISCA-46434;10:47211300-47216400 HI40:ISCA-46435;chr10:47241600-47251000 dbVar;10:47252000-47271150 gnomAD-SV_v2.1_DEL_10_110003;10:47275450-47281000 gnomAD-SV_v2.1_DEL_10_110005;10:47301450-47315100 gnomAD-SV_v2.1_DEL_10_110006;chr10:47531022-47599037 dbVar;10:47531023-47599037 esv3623125;10:47531450-47579000 gnomAD-SV_v2.1_DEL_10_110009... 10:46109534-48312291 nsv516485;10:46931470-47201116 DDD:32937;chr10:47003380-47003486 dbVar;10:47009185-47009299 gnomAD-SV_v2.1_DEL_10_109993;10:47036095-47036306 esv2665191;chr10:47083161-47083233 dbVar;chr10:47088375-47088703 dbVar;10:47088385-47088703 gnomAD-SV_v2.1_DEL_10_109995;chr10:47141536-47141802 dbVar;10:47148774-47150391 1000g;10:47150446-47326492 esv2663732;chr10:47172000-47177000 dbVar;chr10:47177700-47182800 dbVar;chr10:47191200-47201400 dbVar;chr10:47211300-47216400 dbVar;chr10:47252000-47271150 dbVar;chr10:47275450-47281000 dbVar;chr10:47301450-47315100 dbVar;chr10:47383857-47395064 dbVar;10:47531023-47599037 1000g;chr10:47531450-47579000 dbVar... 1006588;1013972;1014290;1014377;166480;629812;2127723;1120842;1548870;2486704;893290;2101919;2312178;1979007;2772902;665181;2077786;1955414;1970979;1407950;3025640;689917;620606;620951;963298;867976;855138;630315;815728;632314;633012;1907;922644;922770;787189;694337;647741;657969;649813;1019156;678322;1019393;1021179;1021180;671781;661728;1066321;1066604;1135949;1796413;670461;... loss;gain 0.415 0.500 10:46976181-46976437 LTR78 10:47590101-47594293;10:47590101-47594293 89.5 -2.98697085794417 -2.90416172871297 8 3.3439e-01 2.9629e-04 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2L (ANTXRLP1, +0.00);3A (9 genes, +0.00);5F (+0.00) 1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 GPRIN2 NM_001385287 1 46992020 47007881 15861 1449 100 no 4 txStart-txEnd 5'UTR-3'UTR 46992020 47007881 1000g;DDD:32922;DDD:32934;DDD:32936;DDD:32937;dbVar;dgv116e214;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46923704-47138897;10:46931463-47389066;10:46931470-47201116;10:46943378-47136996;10:46943378-47742094;10:46966535-48298893;chr10:46976292-47023561;10:46976293-47023561;10:46976293-47023561;10:46976293-47023561;10:46976293-47023561 0.9544 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 IMH 10:46257220-51811936 0.0179 82.54 -3.10473776124822 -3.32991530871711 9721 8 3.8557e-06 2.9629e-04 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 NPY4R NM_001278794 2 47083456 47088320 4864 1128 73 no 2 txStart-txEnd 5'UTR-3'UTR 47083456 47088320 DDD:32922;DDD:32934;DDD:32936;DDD:32937;dbVar;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46923704-47138897;10:46931463-47389066;10:46931470-47201116;10:46943378-47136996;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105 0.1100 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 IMH 10:46257220-51811936 0.0179 66.73 -2.98697085794417 -2.90416172871297 5540 8 8.2144e-07 6.1160e-09 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 LINC00842 NR_033957 2 47096453 47151400 54947 0 0 no 4 txStart-txEnd UTR 47096453 47151400 DDD:32922;DDD:32936;DDD:32937;dbVar;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105 0.1100 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 IMH 10:46257220-51811936 0.0179 643650 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 HNRNPA1P33 NR_003277 2 47133334 47133898 564 0 0 no 1 txStart-txEnd UTR 47133334 47133898 1000g;DDD:32922;DDD:32934;DDD:32936;DDD:32937;dbVar;dgv118e214;dgv221e212;dgv22e55;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46923704-47138897;10:46931463-47389066;10:46931470-47201116;10:46943378-47136996;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105;chr10:47089972-47150813;10:47089973-47150813;10:47089973-47150813;10:47089973-47150813;10:47089973-47150813;chr10:47132970-47134018 0.9544 DDD:32922;DDD:32937;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094 0.0260 IMH 10:46257220-51811936 0.0179 728643 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 ANXA8L1 NM_001098845 3 47157988 47173994 16006 984 100 no 12 txStart-txEnd 5'UTR-3'UTR 47157988 47173994 DDD:32922;DDD:32936;DDD:32937;dbVar;dgv221e212;dgv24e55;gnomAD-SV_v2.1_DUP_10_29720;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105;10:47148500-47181050 0.1100 DDD:32922;DDD:32937;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094;10:47150446-47326492 0.0400 IMH 10:46257220-51811936 0.0179 75.66 728113 9 3.3439e-01 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 FAM25BP NR_104039 1 47177206 47181688 4482 0 0 no 3 txStart-txEnd UTR 47177206 47181688 DDD:32922;DDD:32936;DDD:32937;dbVar;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46931470-47201116;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105 0.1100 DDD:32922;DDD:32937;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931470-47201116;10:46943378-47742094;10:47150446-47326492 0.0400 IMH 10:46257220-51811936 0.0179 89.5 100132929 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 AGAP14P NR_165820 1 47192907 47213477 20570 0 0 no 8 txStart-txEnd UTR 47192907 47213477 DDD:32922;DDD:32936;dbVar;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46931463-47389066;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105 0.1100 DDD:32922;dgv23e55;esv2663732;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:47150446-47326492 0.0400 IMH 10:46257220-51811936 0.0179 653259 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 SHLD2P3 NR_027634 1 47379719 47421238 41519 0 0 no 7 txStart-txEnd UTR 47379719 47421238 DDD:32922;dbVar;dgv221e212;dgv24e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:46966535-48298893;chr10:47048634-47429105 0.1100 DDD:32922;dgv23e55;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094 0.0260 IMH 10:46257220-51811936 0.0179 439965 full=1 +10_46976158_47590995_DUP_1 10 46976158 47590995 614837 DUP Benign NA split q11.22 ANTXRLP1 NR_103827 1 47590260 47640844 735 0 0 no 5 intron4-txEnd UTR 53 3' 47590260 47590995 1000g;DDD:32922;DDD:32970;DDD:32972;TS40:ISCA-46639;dbVar;dgv120e214;dgv221e212;dgv24e55;dgv85n27;esv2421526;gnomAD-SV_v2.1_DUP_10_29734;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;10:46966535-48298893;chr10:47531022-47599037;10:47531023-47599037;10:47531023-47599037;10:47531764-47597768;chr10:47535103-47764425;10:47537369-47652803;10:47539193-47885867;10:47543323-47703613;10:47545737-47759694;chr10:47561240-47680774;chr10:47585775-47727500;10:47585775-47727500 0.1100 1000g;DDD:32922;dbVar;dgv23e55;esv2421526;esv3623125;gnomAD-SV_v2.1_DEL_10_110010;nsv516485 10:46109534-48312291;10:46416327-47756284;10:46943378-47742094;chr10:47531022-47599037;10:47531023-47599037;10:47531023-47599037;10:47537369-47652803;chr10:47582000-47654100;10:47582000-47654100;chr10:47585000-47706000 0.0318 IMH 10:46257220-51811936 0.0179 100996567 full=1 +14_22323880_22952279_DEL_1 14 22323880 22952279 -628399 DEL Benign NA full q11.2 TRD-AS1 OR4E1 LINC02332 1 CEBPE (morbid/RE=GH_promoter_enhancer);CHD8 (HI=3/morbid/RE=GH_enhancer+GH_promoter_enhancer);PABPN1 (morbid/RE=GH_enhancer);SLC7A7 (morbid/RE=ABC_enhancer+EA_enhancer+GH_enhancer+GH_promoter_enhancer);SUPT16H (morbid/RE=GH_enhancer+GH_promoter_enhancer) dbVar:nssv15162475;dbVar:nssv15606090;dbVar:nssv15161908;dbVar:nssv15162476;dbVar:nssv15161629;dbVar:nssv15139565;dbVar:nssv15141262;dbVar:nssv15146564;dbVar:nssv15146758;dbVar:nssv16207193;dbVar:nssv17976958;dbVar:nssv15148269;dbVar:nssv15161107;nssv15161424;dbVar:nssv15161067;dbVar:nssv15132618;dbVar:nssv15134537;dbVar:nssv17955846;dbVar:nssv16091748 14:19000423-107289053;14:19100683-28730087;14:19280734-107287663;14:19327824-107287663;14:19794562-107234280;14:19794562-27768254;14:19794562-34049214;14:20468771-39453619;14:20490853-44562875;14:20511673-44829030;14:20511673-47481203;14:20511673-49111245;14:20511674-107285437;14:20619309-107263478;14:20619309-23911404;14:20880747-25487326;14:20925966-23649548;14:21717094-24027220 0.71;6.53;0.71;0.71;0.72;7.88;4.41;3.31;2.61;2.58;2.33;2.20;0.72;0.73;19.09;13.64;23.07;27.20 dbVar:nssv15119819;dbVar:nssv15145699;dbVar:nssv18330314;dbVar:nssv16208379;dbVar:nssv17976070 14:20223409-23210490;14:20665105-45754005;14:20690197-23114522;14:21143934-23297667;14:21162264-50713602 21.04;2.50;25.92;29.18;2.13 TS40:ISCA-37476 14:22111110-23021097 HI40:ISCA-37476 14:22111110-23021097 14:22111110-23021097 TS40:ISCA-37476;14:22420175-22995788 dgv594e212;14:22558879-22977816 dgv598e212;chr14:22712776-22714043 dbVar;14:22824113-22824253 IMH;chr14:22883062-22883533 dbVar;chr14:22902951-22903446 dbVar;chr14:22948087-22949258 dbVar;chr14:22950998-23140000 dbVar chr14:22095569-22713973 dbVar;chr14:22273689-22404030 dbVar;chr14:22535580-22536565 dbVar;chr14:22576716-22576815 dbVar;chr14:22780292-22782161 dbVar;chr14:22881495-22883533 dbVar;chr14:22898270-22898720 dbVar;chr14:22917975-22918975 dbVar;chr14:22948458-22949258 dbVar chr14:22203999-22380000 dbVar;chr14:22377253-22379001 dbVar;chr14:22386251-22387140 dbVar;chr14:22401118-22401214 dbVar;chr14:22451362-22451480 dbVar;14:22506096-22519924 dgv596e212;chr14:22522033-22522131 dbVar;chr14:22557093-22558668 dbVar;chr14:22566919-22569163 dbVar;chr14:22578988-22580660 dbVar;chr14:22582707-22583756 dbVar;14:22582708-22583756 DDD:42194;14:22582708-22583756 esv2663069;chr14:22592792-22593350 dbVar;chr14:22621082-22623586 dbVar;chr14:22650745-22651552 dbVar;chr14:22690248-22693574 dbVar;14:22740309-22923239 esv3633740;chr14:22753195-22755692 dbVar;chr14:22763326-22765409 dbVar;chr14:22771057-22771863 dbVar... 14:22111110-23021097 HI40:ISCA-37476;chr14:22375089-22375885 dbVar;chr14:22381501-22381559 dbVar;chr14:22392130-22392542 dbVar;chr14:22414330-22458520 dbVar;chr14:22501037-22503623 dbVar;chr14:22520154-22520348 dbVar;14:22549070-22959340 DDD:42190;14:22558879-22995788 dgv599e212;chr14:22570896-22575554 dbVar;chr14:22582165-22583029 dbVar;14:22582707-22583756 gnomAD-SV_v2.1_DEL_14_140471;14:22582708-22583756 IMH;14:22582714-22583762 esv3633739;chr14:22602805-22607184 dbVar;chr14:22629626-22629708 dbVar;chr14:22667031-22667110 dbVar;chr14:22731881-22732433 dbVar;chr14:22740393-22749648 dbVar;chr14:22760947-22761344 dbVar;chr14:22770697-22770784 dbVar... 0.250 0.390 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +14_22323880_22952279_DEL_1 14 22323880 22952279 -628399 DEL Benign NA split q11.2 TRD-AS1 NR_148361 1 22847807 22951948 104141 0 0 no 5 txStart-txEnd UTR 22847807 22951948 TS40:ISCA-37476;dgv594e212;dgv598e212 14:22111110-23021097;14:22420175-22995788;14:22558879-22977816 0.0200 DDD:42190;HI40:ISCA-37476;dgv599e212 14:22111110-23021097;14:22549070-22959340;14:22558879-22995788 0.0107 105370401 full=1 +14_74001652_74022324_DEL_1 14 74001652 74022324 -20672 DEL Benign NA full q24.3 HEATR4;ACOT1 RIOX1 ACOT2 2 COQ6 (morbid/RE=EA_enhancer);ISCA2 (morbid/RE=GH_enhancer);PSEN1 (morbid/RE=EA_enhancer) dbVar:nssv15162475;dbVar:nssv15161908;dbVar:nssv15162476;dbVar:nssv15161629;dbVar:nssv15161107;nssv15161424;dbVar:nssv15161067;dbVar:nssv17976728;dbVar:nssv17517489;dbVar:nssv15161689 14:19000423-107289053;14:19280734-107287663;14:19327824-107287663;14:19794562-107234280;14:20511674-107285437;14:20619309-107263478;14:37671059-106985955;14:54654002-75828024;14:73750742-107285437 0.02;0.02;0.02;0.02;0.02;0.02;0.03;0.10;0.06 dbVar:nssv15161064;dbVar:nssv8639619;dbVar:nssv15161370 14:70028817-82441728;14:73152116-77698582;14:73809922-79301402 0.17;0.45;0.38 DDD:43163;dbVar;dgv655e212;dgv657e212 chr14:73984520-74526186;chr14:73990657-74053945;14:73995762-74031034;chr14:73996900-74040000;14:73998504-74050492;14:74001111-74024031 0.1799 1000g;DDD:43161;DDD:43163;dbVar;dgv401e199;dgv654e212;esv2421969;esv3634909 14:73995762-74031034;14:73996446-74025592;14:73997052-74024450;chr14:73997195-74024603;14:73997196-74024603;14:73997196-74024603;14:73998504-74050492;14:73998977-74028117 0.8135 IMH 14:34547844-76392174 0.0264 chr14:73990657-74053945 dbVar;chr14:73996900-74040000 dbVar;14:74001111-74024031 dgv657e212;14:74001655-74004589 DDD:43169;14:74007816-74040003 IMH;chr14:74007919-74039902 dbVar;14:74008288-74008463 nsv514748;chr14:74011083-74024007 dbVar;14:74011084-74024007 1000g;14:74020544-74030798 DDD:43176 chr14:73984520-74526186 dbVar;14:73995762-74031034 dgv655e212;14:73998504-74050492 DDD:43163;14:74001655-74002844 DDD:43168;14:74007603-74039880 IMH;14:74007864-74040335 IMH;14:74007919-74039902 gnomAD-SV_v2.1_DUP_14_38740;14:74010621-74023183 DDD:43174;14:74011084-74024007 1000g;14:74011084-74024007 dgv407e214 14:73996446-74025592 dgv401e199;chr14:73997195-74024603 dbVar;14:73997196-74024603 esv3634909;14:73998977-74028117 esv2421969;14:74002704-74003063 nsv514747;14:74006839-74031034 dgv661e212;14:74010064-74012567 nsv514749;14:74011084-74024007 1000g;chr14:74019700-74051250 dbVar; 14:73995762-74031034 dgv654e212;14:73997052-74024450 DDD:43161;14:73997196-74024603 1000g;14:73998504-74050492 DDD:43163;14:74001124-74020979 DDD:43165;14:74006839-74024031 dgv660e212;14:74006971-74038879 esv2672436;chr14:74011083-74024007 dbVar;14:74011084-74024007 esv3634910;14:74022142-74045835 DDD:43178 2724245;1059769 loss 0.420 0.380 14:74001513-74001649;14:74001714-74002042 FLAM_A;L1ME4a 14:74021756-74022225 L1M1 14:74000099-74020296 85.75 2.96959666946894 4.05533207481267 6 6.4141e-05 3.5999e-02 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (2 genes, +0.00);5F (+0.00) 1 +14_74001652_74022324_DEL_1 14 74001652 74022324 -20672 DEL Benign NA split q24.3 HEATR4 NM_001220484 1 73945188 74025651 20673 0 0 no 18 intron1-intron1 5'UTR 3130 5' 74001651 74022324 DDD:43163;dbVar;dgv655e212;dgv657e212 chr14:73984520-74526186;chr14:73990657-74053945;14:73995762-74031034;chr14:73996900-74040000;14:73998504-74050492;14:74001111-74024031 0.1799 1000g;DDD:43161;DDD:43163;dbVar;dgv401e199;dgv654e212;esv2421969;esv3634909 14:73995762-74031034;14:73996446-74025592;14:73997052-74024450;chr14:73997195-74024603;14:73997196-74024603;14:73997196-74024603;14:73998504-74050492;14:73998977-74028117 0.8135 IMH 14:34547844-76392174 0.0264 2724245;1059769 loss 85.75 -0.328810289068687 -0.503765753071617 399671 6 1.3711e-29 6.2323e-17 full=1 +14_74001652_74022324_DEL_1 14 74001652 74022324 -20672 DEL Benign NA split q24.3 ACOT1 NM_001037161 2 74003846 74010500 6654 1266 100 no 3 txStart-txEnd 5'UTR-3'UTR 74003846 74010500 DDD:43163;dbVar;dgv655e212;dgv657e212 chr14:73984520-74526186;chr14:73990657-74053945;14:73995762-74031034;chr14:73996900-74040000;14:73998504-74050492;14:74001111-74024031 0.1799 1000g;DDD:43161;DDD:43163;DDD:43165;dbVar;dgv401e199;dgv654e212;esv2421969;esv3634909 14:73995762-74031034;14:73996446-74025592;14:73997052-74024450;chr14:73997195-74024603;14:73997196-74024603;14:73997196-74024603;14:73998504-74050492;14:73998977-74028117;14:74001124-74020979 0.8135 IMH 14:34547844-76392174 0.0264 79.11 2.96959666946894 4.05533207481267 641371 8 6.4141e-05 3.5999e-02 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA full q11.2-q11.1 CHEK2P2;HERC2P3;GOLGA6L6;GOLGA8CP;NBEAP1;MIR3118-2;POTEB2;MIR5701-1;LINC01193;FAM30C;LOC646214;CXADRP2;POTEB;NF1P2;LINC02203;OR4M2-OT1;OR4M2;OR4N4;OR4N3P;IGHV1OR15-1;IGHV1OR15-3;MIR1268A;REREP3;MIR4509-1;GOLGA8DP;GOLGA6L1 TUBGCP5 26 ADAM22 (morbid/RE=mTL_miRNA);AGO2 (morbid/RE=mTL_miRNA);AIP (morbid/RE=mTL_miRNA);BLOC1S3 (morbid/RE=mTL_miRNA);CA12 (morbid/RE=mTL_miRNA);CACNA1H (morbid/RE=mTL_miRNA);CAMK2G (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CERS1 (morbid/RE=mTL_miRNA);DHCR7 (morbid/RE=mTL_miRNA);DICER1 (HI=3/morbid/RE=mTL_miRNA);EDAR (morbid/RE=mTL_miRNA);EGLN1 (morbid/RE=mTL_miRNA);EPB41 (morbid/RE=mTL_miRNA);EPHA2 (morbid/RE=mTL_miRNA);ERBB3 (morbid/RE=mTL_miRNA);FRMPD4 (morbid/RE=mTL_miRNA);GABRB2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);GCK (morbid/RE=mTL_miRNA);HPRT1 (HI=3/morbid/RE=mTL_miRNA);HRAS (morbid/RE=mTL_miRNA);HSPD1 (morbid/RE=mTL_miRNA);IL6ST (morbid/RE=mTL_miRNA);INF2 (morbid/RE=mTL_miRNA);ISCU (morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNJ10 (morbid/RE=mTL_miRNA);KIF23 (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);LRIG2 (morbid/RE=mTL_miRNA);MAGEL2 (morbid/RE=ABC_enhancer);MAPK1 (morbid/RE=mTL_miRNA);MAPKAPK5 (morbid/RE=mTL_miRNA);MKRN3 (morbid/RE=ABC_enhancer);NDUFS1 (morbid/RE=mTL_miRNA);NEK9 (morbid/RE=mTL_miRNA);NIPA1 (morbid/RE=ABC_enhancer);NPM1 (morbid/RE=mTL_miRNA);ORAI1 (morbid/RE=mTL_miRNA);PEX26 (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);POT1 (morbid/RE=mTL_miRNA);PRKCA (morbid/RE=mTL_miRNA);PRLR (morbid/RE=mTL_miRNA);PURA (HI=3/morbid/RE=mTL_miRNA);RAC3 (morbid/RE=mTL_miRNA);SCN1A (HI=3/morbid/RE=mTL_miRNA);SGPL1 (morbid/RE=mTL_miRNA);SH2D1A (HI=3/morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC24A4 (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SLC7A14 (morbid/RE=mTL_miRNA);SLC7A7 (morbid/RE=mTL_miRNA);SMAD4 (HI=3/morbid/RE=mTL_miRNA);SMAD6 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SMOC2 (morbid/RE=mTL_miRNA);SOX17 (morbid/RE=mTL_miRNA);TBL1XR1 (HI=3/morbid/RE=mTL_miRNA);TPM4 (morbid/RE=mTL_miRNA);TRIP11 (morbid/RE=mTL_miRNA);TULP1 (morbid/RE=mTL_miRNA);USP48 (morbid/RE=mTL_miRNA);WDR81 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA);ZNF711 (morbid/RE=mTL_miRNA) dbVar:nssv15172447;dbVar:nssv15149081;dbVar:nssv15148902;dbVar:nssv15125410;dbVar:nssv15127689;dbVar:nssv15127462;dbVar:nssv15126524;dbVar:nssv15124656;dbVar:nssv15127659;dbVar:nssv15126021;dbVar:nssv15172190;dbVar:nssv15150569;dbVar:nssv15147052;dbVar:nssv15145742;dbVar:nssv15147053;dbVar:nssv15175556;dbVar:nssv15145744;dbVar:nssv15774514;dbVar:nssv15148785;dbVar:nssv15605894;dbVar:nssv15149135;dbVar:nssv15148575;dbVar:nssv15147687;dbVar:nssv15605895;dbVar:nssv15147058;dbVar:nssv15145747;dbVar:nssv15146452;dbVar:nssv15149084;dbVar:nssv15147355;dbVar:nssv15149616;dbVar:nssv15147801;dbVar:nssv15146958;dbVar:nssv15149124;dbVar:nssv15123304;dbVar:nssv15147513;dbVar:nssv15127079;dbVar:nssv15605897;dbVar:nssv15605899;dbVar:nssv15125414;dbVar:nssv15148135;dbVar:nssv15146406;dbVar:nssv15148053;dbVar:nssv15145661;nssv15146195;dbVar:nssv15145807;dbVar:nssv15147309;dbVar:nssv15145805;nssv15146672;dbVar:nssv15145677;dbVar:nssv18841879;dbVar:nssv16207640;dbVar:nssv16215281;dbVar:nssv15755702;dbVar:nssv15145809;nssv15150756;dbVar:nssv15145849;dbVar:nssv15146718;dbVar:nssv15148834;dbVar:nssv15147450;nssv15148847;dbVar:nssv15146035;dbVar:nssv15148907;dbVar:nssv15146735;dbVar:nssv15148824;dbVar:nssv15146042;dbVar:nssv15147411;dbVar:nssv15147985;dbVar:nssv15148007;dbVar:nssv15146680;dbVar:nssv15147424;dbVar:nssv15148131;dbVar:nssv15145909 15:20016812-102493540;15:20044343-28924405;15:20045835-32914140;15:20063341-102521392;15:20063341-29093456;15:20063341-29209620;15:20063341-30448351;15:20063341-32439302;15:20063341-32942613;15:20063341-32986584;15:20071674-102461162;15:20071674-30737344;15:20085003-28947309;15:20085003-29210720;15:20085004-28178425;15:20102541-29031690;15:20110723-28408897;15:20179528-32998070;15:20190549-28406650;15:20190549-30300265;15:20190549-32386089;15:20190549-32917801;15:20190549-32917857;15:20191653-28525310;15:20207714-30641396;15:20207714-32413623;15:20251769-28631040;15:20306550-26208861;15:20686197-30509384;15:20733396-102511616;15:20733396-28406650;15:20733396-28406709;15:20848461-27662530;15:21129985-28535266;15:22304597-28577787;15:22318645-29209620;15:22382861-32396457;15:22383300-32917689;15:22409402-28952953;15:22652061-28883749;15:22669053-28435888;15:22698523-28940098;15:22698523-29030517;15:22698523-29085896;15:22698523-30366124;15:22698523-30653936;15:22698523-32899558;15:22742397-28567325;15:22750306-23114374;15:22750306-23164315;15:22750306-23226254;15:22765629-28520313;15:22765629-28557186;15:22765629-28559402;15:22765629-28912057;15:22765629-29006852;15:22765629-29085896;15:22765629-29096442;15:22765629-30366124;15:22765629-30653936;15:22765629-30819509;15:22765629-38837526;15:22765638-28520316;15:22765638-29085888;15:22765638-30366079;15:22765638-31467435;15:22765638-32509932;15:22765638-32899558 2.83;26.27;18.13;2.83;25.83;25.51;22.46;18.85;18.11;18.05;2.83;21.87;26.32;25.56;28.82;26.13;28.11;18.20;28.39;23.08;19.13;18.33;18.33;27.99;22.36;19.11;27.84;39.52;21.17;2.49;26.49;26.49;28.14;22.09;7.35;6.49;3.82;3.63;5.44;1.82;1.68;1.08;1.06;1.05;0.88;0.84;0.66;0.40;4.23;3.72;3.23;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00;0.00 dbVar:nssv16865885;dbVar:nssv18326337;dbVar:nssv15605896;dbVar:nssv15123310;dbVar:nssv18841918;dbVar:nssv16208656;dbVar:nssv18792791;dbVar:nssv16215320;dbVar:nssv15147060;dbVar:nssv15146946;dbVar:nssv15147062;dbVar:nssv15153078;dbVar:nssv18792767;dbVar:nssv15160814;dbVar:nssv15160813;dbVar:nssv15159751;dbVar:nssv15160812;dbVar:nssv16216734;dbVar:nssv16297059;dbVar:nssv15147987;dbVar:nssv16215225;dbVar:nssv16208660;dbVar:nssv15160288;dbVar:nssv15146407;dbVar:nssv15145750;dbVar:nssv16297060;dbVar:nssv15149692;dbVar:nssv15147712;dbVar:nssv15145753;dbVar:nssv15147316;dbVar:nssv15145752;nssv15148282;dbVar:nssv15146196;nssv15146797;dbVar:nssv15146673;dbVar:nssv15147319;dbVar:nssv18326338;dbVar:nssv17955873;dbVar:nssv18842037;dbVar:nssv15145025;dbVar:nssv15145441;dbVar:nssv15145201;dbVar:nssv17517455;dbVar:nssv16297061;dbVar:nssv16208668;dbVar:nssv15129123;dbVar:nssv16215325;dbVar:nssv15130100;dbVar:nssv16209033;dbVar:nssv15172201;dbVar:nssv15606130;dbVar:nssv15132915;nssv16736610;dbVar:nssv16736624;nssv16736646;dbVar:nssv16091751;dbVar:nssv15130140;dbVar:nssv15146040;dbVar:nssv15148147;dbVar:nssv15146043;dbVar:nssv15145953;dbVar:nssv15148915;dbVar:nssv15148857;dbVar:nssv15146645 15:20612841-23272733;15:20739498-28566579;15:20848751-32925141;15:21129985-32514926;15:21172301-26208861;15:21903816-23272733;15:22070541-23262343;15:22299435-23226254;15:22318598-28940098;15:22427967-23226254;15:22432629-30641396;15:22503622-23091180;15:22646195-23174919;15:22646195-23191269;15:22646195-23199953;15:22646195-23302626;15:22646195-23428906;15:22646693-28964445;15:22646800-23301267;15:22652048-28705151;15:22652331-23226254;15:22652331-23272733;15:22652331-29050198;15:22669053-28435888;15:22669053-30401486;15:22695843-23300942;15:22698523-28406650;15:22698523-28406709;15:22698523-28520313;15:22698523-28557186;15:22698523-28691460;15:22698523-29030517;15:22698523-29085896;15:22698523-38381783;15:22736247-23265381;15:22743128-23246000;15:22744150-23246340;15:22746945-23102836;15:22746945-23121448;15:22746945-23199421;15:22746949-23323445;15:22749636-23301317;15:22750306-23109890;15:22750306-23164315;15:22750306-23222284;15:22750306-23226254;15:22750306-23272733;15:22750306-28535266;15:22751195-23251194;15:22765629-23085096;15:22765629-23191062;15:22765629-23217514;15:22765629-23300287;15:22765629-28559402;15:22765629-28691460;15:22765629-28912057;15:22765629-28940098;15:22765629-28976193;15:22765629-32676855;15:22765638-29085888 80.94;25.89;15.87;14.37;31.64;62.96;58.33;50.31;6.75;42.31;4.06;44.60;22.60;21.92;21.58;18.20;15.27;1.88;18.17;1.88;19.75;18.27;1.77;1.68;1.25;11.54;1.18;1.18;1.15;1.15;1.12;1.06;1.05;0.43;5.56;4.49;4.29;5.27;5.00;4.14;3.25;2.91;4.28;3.72;3.26;3.23;2.94;0.27;2.90;0.02;0.01;0.01;0.01;0.00;0.00;0.00;0.00;0.00;0.00;0.00 dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764 0.1500 dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284 0.1000 15:20037886-21236662 DDD:43986;15:20167087-21200251 dgv91e55;15:20167087-22869764 dgv93e55;chr15:20198164-20894589 dbVar;15:20388742-22207639 TS40:ISCA-46686;15:20556528-20624827 DDD:44039;chr15:20598942-20625797 dbVar;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20650251-20710056 nsv514763;15:20686000-20711550 gnomAD-SV_v2.1_DUP_15_39411;chr15:20717000-20724000 dbVar;15:20729300-20736525 gnomAD-SV_v2.1_DUP_15_39414;15:20731675-20778150 gnomAD-SV_v2.1_DUP_15_39416;15:20746872-20747023 DDD:44052;15:20751226-21293606 esv3892595;15:20779661-20885221 DDD:44055;15:20783000-20799000 gnomAD-SV_v2.1_DUP_15_39419;15:20786000-20827000 gnomAD-SV_v2.1_DUP_15_39420;chr15:20846721-20867075 dbVar... 15:20016329-23487546 dgv40e203;15:20144627-21266621 DDD:43992;15:20167087-22588036 dgv92e55;15:20182203-22608281 DDD:44001;15:20203950-22588019 dgv2191n100;15:20550641-20637800 nsv514762;15:20575412-20599635 DDD:44041;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 dgv430e214;chr15:20686000-20711550 dbVar;15:20706000-20747000 gnomAD-SV_v2.1_DUP_15_39412;15:20717000-20724000 gnomAD-SV_v2.1_DUP_15_39413;15:20730500-20754075 gnomAD-SV_v2.1_DUP_15_39415;15:20735000-20745000 gnomAD-SV_v2.1_DUP_15_39417;15:20749534-20773538 DDD:44053;chr15:20760182-20760295 dbVar;chr15:20783000-20799000 dbVar;chr15:20786000-20827000 dbVar;15:20807000-20821500 gnomAD-SV_v2.1_DUP_15_39421... 15:20144627-21266621 DDD:43992;15:20167090-22588036 dgv96e55;15:20396654-20496584 DDD:44013;15:20468142-20468256 DDD:44028;15:20547692-20548186 IMH;15:20575412-20599635 DDD:44041;15:20581464-20589613 esv2674516;15:20587419-20587601 gnomAD-SV_v2.1_DEL_15_145824;15:20698000-20706500 gnomAD-SV_v2.1_DEL_15_145825;chr15:20729175-20745525 dbVar;15:20749534-20773538 DDD:44053;chr15:20781000-20811000 dbVar;chr15:20820627-20821162 dbVar;chr15:20820696-20820748 dbVar;chr15:20891428-20891785 dbVar;chr15:20976350-20994050 dbVar;15:21042050-21056300 HI40:ISCA-46469;15:21042050-21056300 gnomAD-SV_v2.1_DEL_15_145837;chr15:21200932-21201488 dbVar;15:21321039-21325126 DDD:44088;15:21399090-22661412 DDD:44096... 15:20016329-23487546 dgv40e203;15:20167087-23222284 dgv94e55;15:20182203-22608281 DDD:44001;chr15:20436850-20437443 dbVar;chr15:20511834-20511893 dbVar;15:20556528-20624827 DDD:44039;15:20581414-20589751 IMH;chr15:20587419-20587601 dbVar;chr15:20698000-20706500 dbVar;15:20729175-20745525 HI40:ISCA-46468;chr15:20732300-20738500 dbVar;15:20779661-20885221 DDD:44055;chr15:20806100-20823500 dbVar;15:20820627-20821162 gnomAD-SV_v2.1_DEL_15_145830;chr15:20881220-20881325 dbVar;15:20945597-20946011 esv2664547;chr15:21017763-21017994 dbVar;chr15:21042050-21056300 dbVar;15:21069662-21311925 DDD:44068;chr15:21282800-21314300 dbVar;chr15:21348205-21348677 dbVar... 650272;863409;230;2184774;679816;647783;656664;688870;893394;681561;683397;680362;846716;872413;658002;669462;670005;652017;920564;1571937;1923126;2037878;3089073;1104581;1530844;2453908;3049079;1892580;669650;674986;653193;696167;2579336;702830;2734909;1080050;1597023;2373586;2580364;2726476;2754714;661971;679225;1494768;1799616;1254151;670502;658452;2684440;1935900;1278559;... loss;gain 0.380 0.455 15:22765220-22765620;15:22765771-22766019 L1MC4;L2 15:20345908-20498625;15:20390971-20432871 15:22754054-22770109 15:20200401-22365100 High Signal Region 93.81 2.22375841006203 2.58284576037233 8 3.5277e-01 5.7189e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);3A (26 genes, +0.00);5F (+0.00) 1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.1 CHEK2P2 NR_038836 1 20487996 20496811 8815 0 0 no 6 txStart-txEnd UTR 20487996 20496811 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 646096 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2-q11.1 HERC2P3 NR_036432 1 20613648 20711433 97785 0 0 no 26 txStart-txEnd UTR 20613648 20711433 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 283755 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA6L6 NM_001145004 2 20737093 20747114 10021 2175 100 no 11 txStart-txEnd 5'UTR-3'UTR 20737093 20747114 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;gnomAD-SV_v2.1_DUP_15_39415;gnomAD-SV_v2.1_DUP_15_39416 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639;15:20730500-20754075;15:20731675-20778150 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 93.81 0.630577750419089 0.0606178603183018 727832 8 2.2875e-19 8.6864e-02 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA8CP NR_027411 2 20767673 20781026 13353 0 0 no 18 txStart-txEnd UTR 20767673 20781026 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 729786 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 NBEAP1 NR_027992 1 20874796 20961480 86684 0 0 no 3 txStart-txEnd UTR 20874796 20961480 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 606 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR3118-2 NR_036062 2 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 100422949 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 POTEB2 NM_001277303 1 21040700 21071643 30943 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 21040700 21071643 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595;nsv514765 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060;15:21040437-21077011 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 92.58 2.22375841006203 2.58284576037233 100287399 8 4.2457e-02 5.7189e-01 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR5701-1 NR_049886 1 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060;15:21069662-21311925;15:21145102-21164300 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21069662-21311925 0.2710 100847060 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LINC01193 NR_040094 1 21145766 21198633 52867 0 0 no 5 txStart-txEnd UTR 21145766 21198633 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060;15:21069662-21311925 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21069662-21311925 0.2710 348120 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 FAM30C NR_145444 1 21208605 21255165 46560 0 0 no 4 txStart-txEnd UTR 21208605 21255165 DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20144627-21266621;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;15:21069662-21311925 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21069662-21311925 0.2710 654499 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LOC646214 NR_027053 2 21932513 21940739 8226 0 0 no 1 txStart-txEnd UTR 21932513 21940739 DDD:44001;DDD:44096;DDD:44097;DDD:44098;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793;15:21904679-21949433;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44097;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21904679-21949433;15:21906623-22142846 0.1300 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 CXADRP2 NR_024387 1 22014402 22016878 2476 0 0 no 1 txStart-txEnd UTR 22014402 22016878 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 646243 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 POTEB NM_001277304 2 22051852 22083259 31407 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22051852 22083259 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 91.86 100996331 9 3.5277e-01 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 NF1P2 NR_028506 2 22133180 22145802 12622 0 0 no 8 txStart-txEnd UTR 22133180 22145802 DDD:44001;DDD:44096;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 440225 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 LINC02203 NR_152818 1 22195582 22199978 4396 0 0 no 3 txStart-txEnd UTR 22195582 22199978 DDD:44001;DDD:44096;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 727924 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4M2-OT1 NR_110480 1 22278030 22383564 105534 0 0 no 9 txStart-txEnd UTR 22278030 22383564 DDD:44001;DDD:44096;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 690131;665411;669653;661973;681562;718266;688758;747790;701704;664511 loss 101927079 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4M2 NM_001004719 2 22368477 22369561 1084 942 95 no 1 txStart-txEnd 5'UTR-3'UTR 22368477 22369561 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv435e214;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22425022;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;chr15:22335841-22425022;chr15:22335841-22590413;chr15:22340286-22590413;chr15:22343965-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;chr15:22344732-22425022;15:22360686-22387071 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dbVar;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;chr15:22343965-22372302;15:22360686-22387071 0.1300 76.23 390538 9 3.9447e-08 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4N4 NM_001005241 4 22382472 22383813 1341 951 100 no 1 txStart-txEnd 5'UTR-3'UTR 22382472 22383813 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22425022;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;chr15:22335841-22425022;chr15:22335841-22590413;chr15:22340286-22590413;chr15:22344732-22425022;15:22360686-22387071 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:22360686-22387071 0.1300 75.33 -0.271906921498889 -0.565772314050669 283694 9 5.1332e-05 1.8051e-02 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 OR4N3P NR_028067 1 22413461 22414398 937 0 0 no 1 txStart-txEnd UTR 22413461 22414398 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44129;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv437e214;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22425022;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;chr15:22335841-22425022;chr15:22335841-22590413;chr15:22340286-22590413;chr15:22344732-22425022;chr15:22383477-22434169;15:22383478-22434169;15:22383478-22434169;15:22383478-22434169;15:22383478-22434169;15:22383478-22434169;15:22411349-22577661 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44129;dbVar;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;chr15:22383477-22434169;15:22411349-22577661 0.1300 390539 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 IGHV1OR15-1 NR_135694 1 22448239 22448881 642 0 0 no 2 txStart-txEnd UTR 22448239 22448881 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44129;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv438e214;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;chr15:22335841-22590413;chr15:22340286-22590413;15:22411349-22577661;chr15:22425022-22472949;chr15:22425022-22473149;chr15:22425022-22473349;chr15:22425022-22590413;chr15:22446739-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44129;dbVar;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:22411349-22577661;chr15:22446739-22506103 0.1300 388077 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 IGHV1OR15-3 NR_135666 1 22465805 22466547 742 0 0 no 2 txStart-txEnd UTR 22465805 22466547 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv438e214;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;chr15:22335841-22590413;chr15:22340286-22590413;15:22411349-22577661;chr15:22425022-22472949;chr15:22425022-22473149;chr15:22425022-22473349;chr15:22425022-22590413;chr15:22446739-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103;15:22446740-22506103 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44129;dbVar;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;chr15:22446739-22506103 0.1300 646370 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR1268A NR_031672 1 22513228 22513280 52 0 0 no 1 txStart-txEnd UTR 22513228 22513280 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;chr15:22335841-22590413;chr15:22340286-22590413;15:22411349-22577661;chr15:22425022-22590413;chr15:22473149-22590413 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44129;DDD:44139;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;15:22475646-22537915 0.1300 100302233 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 REREP3 NR_033735 1 22546564 22570831 24267 0 0 no 3 txStart-txEnd UTR 22546564 22570831 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44129;DDD:44147;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;chr15:22335841-22590413;chr15:22340286-22590413;15:22411349-22577661;chr15:22425022-22590413;chr15:22473149-22590413;15:22519942-22726364 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44129;DDD:44147;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22320058-22588019;15:22411349-22577661;15:22519942-22726364 0.1300 646396 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 MIR4509-1 NR_039732 1 22675147 22675241 94 0 0 no 1 txStart-txEnd UTR 22675147 22675241 DDD:44147;DDD:44168;dbVar;dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764;15:22519942-22726364;chr15:22646309-22760311;15:22650162-22738662;chr15:22670204-22760311 0.1500 DDD:44147;DDD:44168;dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284;15:22519942-22726364;15:22650162-22738662 0.1000 IMH 15:22658037-28688749 0.1570 100616223 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA8DP NR_027407 1 22702284 22715728 13444 0 0 no 18 txStart-txEnd UTR 22702284 22715728 DDD:44147;DDD:44168;dbVar;dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764;15:22519942-22726364;chr15:22646309-22760311;15:22650162-22738662;chr15:22670204-22760311 0.1500 DDD:44147;DDD:44168;dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284;15:22519942-22726364;15:22650162-22738662 0.1000 IMH 15:22658037-28688749 0.1570 100132979 full=1 +15_20432852_22765687_DUP_1 15 20432852 22765687 2332835 DUP Benign NA split q11.2 GOLGA6L1 NM_001001413 3 22736245 22746002 9757 2007 100 no 9 txStart-txEnd 5'UTR-3'UTR 22736245 22746002 dbVar;dgv40e203;dgv93e55 15:20016329-23487546;15:20167087-22869764;chr15:22646309-22760311;chr15:22670204-22760311 0.1500 dgv40e203;dgv94e55 15:20016329-23487546;15:20167087-23222284 0.1000 IMH 15:22658037-28688749 0.1570 93.48 283767 8 2.3586e-12 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA full q11.2-q11.1 HERC2P3;GOLGA6L6;GOLGA8CP;NBEAP1;MIR3118-2;POTEB2;MIR5701-1;LINC01193;FAM30C;LOC646214;CXADRP2;POTEB;NF1P2;LINC02203;OR4M2-OT1;OR4M2;OR4N4 CHEK2P2 OR4N3P 17 ADAM22 (morbid/RE=mTL_miRNA);CA12 (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);DICER1 (HI=3/morbid/RE=mTL_miRNA);EDAR (morbid/RE=mTL_miRNA);EGLN1 (morbid/RE=mTL_miRNA);ERBB3 (morbid/RE=mTL_miRNA);GABRB2 (morbid/RE=mTL_miRNA);GATA6 (HI=3/morbid/RE=mTL_miRNA);HSPD1 (morbid/RE=mTL_miRNA);IL6ST (morbid/RE=mTL_miRNA);INF2 (morbid/RE=mTL_miRNA);ISCU (morbid/RE=mTL_miRNA);KAT6B (HI=3/morbid/RE=mTL_miRNA);KCNJ10 (morbid/RE=mTL_miRNA);KLHL3 (morbid/RE=mTL_miRNA);KMT2D (HI=3/morbid/RE=mTL_miRNA);LRIG2 (morbid/RE=mTL_miRNA);MAGEL2 (morbid/RE=ABC_enhancer);MAPKAPK5 (morbid/RE=mTL_miRNA);MKRN3 (morbid/RE=ABC_enhancer);NDUFS1 (morbid/RE=mTL_miRNA);NIPA1 (morbid/RE=ABC_enhancer);NPM1 (morbid/RE=mTL_miRNA);PEX26 (morbid/RE=mTL_miRNA);PIGP (morbid/RE=mTL_miRNA);POT1 (morbid/RE=mTL_miRNA);PRLR (morbid/RE=mTL_miRNA);PURA (HI=3/morbid/RE=mTL_miRNA);RAC3 (morbid/RE=mTL_miRNA);SH2D1A (HI=3/morbid/RE=mTL_miRNA);SKI (morbid/RE=mTL_miRNA);SLC6A6 (morbid/RE=mTL_miRNA);SLC7A14 (morbid/RE=mTL_miRNA);SLC7A7 (morbid/RE=mTL_miRNA);SMAD4 (HI=3/morbid/RE=mTL_miRNA);SMAD6 (morbid/RE=mTL_miRNA);SMOC1 (morbid/RE=mTL_miRNA);SMOC2 (morbid/RE=mTL_miRNA);SOX17 (morbid/RE=mTL_miRNA);TULP1 (morbid/RE=mTL_miRNA);USP48 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA);ZNF711 (morbid/RE=mTL_miRNA) dbVar:nssv15172447;dbVar:nssv15149081;dbVar:nssv15148902;dbVar:nssv15125410;dbVar:nssv15127689;dbVar:nssv15127462;dbVar:nssv15126524;dbVar:nssv15124656;dbVar:nssv15127659;dbVar:nssv15126021;dbVar:nssv15172190;dbVar:nssv15150569;dbVar:nssv15147052;dbVar:nssv15145742;dbVar:nssv15147053;dbVar:nssv15175556;dbVar:nssv15145744;dbVar:nssv15774514;dbVar:nssv15148785;dbVar:nssv15605894;dbVar:nssv15149135;dbVar:nssv15148575;dbVar:nssv15147687;dbVar:nssv15605895;dbVar:nssv15147058;dbVar:nssv15145747;dbVar:nssv15146452;dbVar:nssv15149084;dbVar:nssv15147355;dbVar:nssv15149616;dbVar:nssv15147801;dbVar:nssv15146958;dbVar:nssv15149124;dbVar:nssv15123304;dbVar:nssv15147513;dbVar:nssv15127079;dbVar:nssv15605897;dbVar:nssv15605899 15:20016812-102493540;15:20044343-28924405;15:20045835-32914140;15:20063341-102521392;15:20063341-29093456;15:20063341-29209620;15:20063341-30448351;15:20063341-32439302;15:20063341-32942613;15:20063341-32986584;15:20071674-102461162;15:20071674-30737344;15:20085003-28947309;15:20085003-29210720;15:20085004-28178425;15:20102541-29031690;15:20110723-28408897;15:20179528-32998070;15:20190549-28406650;15:20190549-30300265;15:20190549-32386089;15:20190549-32917801;15:20190549-32917857;15:20191653-28525310;15:20207714-30641396;15:20207714-32413623;15:20251769-28631040;15:20306550-26208861;15:20686197-30509384;15:20733396-102511616;15:20733396-28406650;15:20733396-28406709;15:20848461-27662530;15:21129985-28535266;15:22304597-28577787;15:22318645-29209620;15:22382861-32396457;15:22383300-32917689 2.24;20.77;14.34;2.24;20.43;20.17;17.76;14.91;14.32;14.27;2.24;17.30;20.82;20.22;22.79;20.66;22.23;14.39;22.45;18.25;15.13;14.49;14.49;22.14;17.68;15.11;22.02;31.26;17.54;2.05;21.84;21.84;22.91;17.28;1.67;1.32;0.26;0.25 dbVar:nssv16865885;dbVar:nssv18326337;dbVar:nssv15605896;dbVar:nssv15123310;dbVar:nssv18841918;dbVar:nssv16208656;dbVar:nssv18792791;dbVar:nssv16215320;dbVar:nssv15147060 15:20612841-23272733;15:20739498-28566579;15:20848751-32925141;15:21129985-32514926;15:21172301-26208861;15:21903816-23272733;15:22070541-23262343;15:22299435-23226254;15:22318598-28940098 67.54;21.33;12.92;11.24;24.56;36.93;28.43;11.86;1.37 DDD:44001;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019 0.3900 DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.1300 15:20037886-21236662 DDD:43986;15:20167087-21200251 dgv91e55;15:20167087-22869764 dgv93e55;chr15:20198164-20894589 dbVar;15:20388742-22207639 TS40:ISCA-46686;15:20556528-20624827 DDD:44039;chr15:20598942-20625797 dbVar;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20650251-20710056 nsv514763;15:20686000-20711550 gnomAD-SV_v2.1_DUP_15_39411;chr15:20717000-20724000 dbVar;15:20729300-20736525 gnomAD-SV_v2.1_DUP_15_39414;15:20731675-20778150 gnomAD-SV_v2.1_DUP_15_39416;15:20746872-20747023 DDD:44052;15:20751226-21293606 esv3892595;15:20779661-20885221 DDD:44055;15:20783000-20799000 gnomAD-SV_v2.1_DUP_15_39419;15:20786000-20827000 gnomAD-SV_v2.1_DUP_15_39420;chr15:20846721-20867075 dbVar... 15:20016329-23487546 dgv40e203;15:20144627-21266621 DDD:43992;15:20167087-22588036 dgv92e55;15:20182203-22608281 DDD:44001;15:20203950-22588019 dgv2191n100;15:20550641-20637800 nsv514762;15:20575412-20599635 DDD:44041;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 1000g;15:20598943-20625797 dgv430e214;chr15:20686000-20711550 dbVar;15:20706000-20747000 gnomAD-SV_v2.1_DUP_15_39412;15:20717000-20724000 gnomAD-SV_v2.1_DUP_15_39413;15:20730500-20754075 gnomAD-SV_v2.1_DUP_15_39415;15:20735000-20745000 gnomAD-SV_v2.1_DUP_15_39417;15:20749534-20773538 DDD:44053;chr15:20760182-20760295 dbVar;chr15:20783000-20799000 dbVar;chr15:20786000-20827000 dbVar;15:20807000-20821500 gnomAD-SV_v2.1_DUP_15_39421... 15:20144627-21266621 DDD:43992;15:20167090-22588036 dgv96e55;15:20556528-20624827 DDD:44039;15:20581414-20589751 IMH;chr15:20587419-20587601 dbVar;chr15:20698000-20706500 dbVar;15:20729175-20745525 HI40:ISCA-46468;chr15:20732300-20738500 dbVar;15:20779661-20885221 DDD:44055;chr15:20806100-20823500 dbVar;15:20820627-20821162 gnomAD-SV_v2.1_DEL_15_145830;chr15:20881220-20881325 dbVar;15:20945597-20946011 esv2664547;chr15:21017763-21017994 dbVar;chr15:21042050-21056300 dbVar;15:21069662-21311925 DDD:44068;chr15:21282800-21314300 dbVar;chr15:21348205-21348677 dbVar;chr15:21888050-21888102 dbVar;15:21904679-21949433 DDD:44097;chr15:21991127-21991414 dbVar... 15:20016329-23487546 dgv40e203;15:20167087-23222284 dgv94e55;15:20182203-22608281 DDD:44001;15:20575412-20599635 DDD:44041;15:20581464-20589613 esv2674516;15:20587419-20587601 gnomAD-SV_v2.1_DEL_15_145824;15:20698000-20706500 gnomAD-SV_v2.1_DEL_15_145825;chr15:20729175-20745525 dbVar;15:20749534-20773538 DDD:44053;chr15:20781000-20811000 dbVar;chr15:20820627-20821162 dbVar;chr15:20820696-20820748 dbVar;chr15:20891428-20891785 dbVar;chr15:20976350-20994050 dbVar;15:21042050-21056300 HI40:ISCA-46469;15:21042050-21056300 gnomAD-SV_v2.1_DEL_15_145837;chr15:21200932-21201488 dbVar;15:21321039-21325126 DDD:44088;15:21399090-22661412 DDD:44096;15:21888050-21888102 gnomAD-SV_v2.1_DEL_15_145844;15:21906623-22142846 DDD:44098... 1015796;1015998;1016239;605205;842984;846405;864067;864398;865855;883822;909114;909684;918629;923436;603901;908486;856653;857304;863410;922332;818827;780982;926115;606172;606967;819083;901378;910495;910633;897929;930366;602746;1016982;1017230;1018200;1018423;1018674;604540;781874;811310;820414;834769;862113;862353;864719;865161;867169;868098;869021;880074;881307;... gain;loss 0.310 0.275 15:20564282-20581643 15:22292726-22423285 15:20200401-22365100 High Signal Region 15:22387401-22749100 Low Mappability 93.81 2.22375841006203 2.58284576037233 8 3.5277e-01 5.7189e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (17 genes, +0.00);5F (+0.00) 1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2-q11.1 HERC2P3 NR_036432 1 20613648 20711433 97785 0 0 no 26 txStart-txEnd UTR 20613648 20711433 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 283755 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 GOLGA6L6 NM_001145004 2 20737093 20747114 10021 2175 100 no 11 txStart-txEnd 5'UTR-3'UTR 20737093 20747114 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;gnomAD-SV_v2.1_DUP_15_39415;gnomAD-SV_v2.1_DUP_15_39416 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639;15:20730500-20754075;15:20731675-20778150 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 93.81 0.630577750419089 0.0606178603183018 727832 8 2.2875e-19 8.6864e-02 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 GOLGA8CP NR_027411 2 20767673 20781026 13353 0 0 no 18 txStart-txEnd UTR 20767673 20781026 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;chr15:20198164-20894589;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 729786 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 NBEAP1 NR_027992 1 20874796 20961480 86684 0 0 no 3 txStart-txEnd UTR 20874796 20961480 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 606 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR3118-2 NR_036062 2 21038123 21038198 75 0 0 no 1 txStart-txEnd UTR 21038123 21038198 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 100422949 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 POTEB2 NM_001277303 1 21040700 21071643 30943 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 21040700 21071643 DDD:43986;DDD:43992;DDD:44001;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595;nsv514765 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060;15:21040437-21077011 0.3900 DDD:43992;DDD:44001;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281 0.2710 92.58 2.22375841006203 2.58284576037233 100287399 8 4.2457e-02 5.7189e-01 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 MIR5701-1 NR_049886 1 21145580 21145662 82 0 0 no 1 txStart-txEnd UTR 21145580 21145662 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;TS40:ISCA-46688;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060;15:21069662-21311925;15:21145102-21164300 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21069662-21311925 0.2710 100847060 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LINC01193 NR_040094 1 21145766 21198633 52867 0 0 no 5 txStart-txEnd UTR 21145766 21198633 DDD:43986;DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv91e55;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20037886-21236662;15:20144627-21266621;15:20167087-21200251;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;chr15:20935189-21205060;chr15:21033616-21205060;15:21069662-21311925 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21069662-21311925 0.2710 348120 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 FAM30C NR_145444 1 21208605 21255165 46560 0 0 no 4 txStart-txEnd UTR 21208605 21255165 DDD:43992;DDD:44001;DDD:44068;TS40:ISCA-46686;dgv2191n100;dgv40e203;dgv92e55;dgv93e55;esv3892595 15:20016329-23487546;15:20144627-21266621;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:20751226-21293606;15:21069662-21311925 0.3900 DDD:43992;DDD:44001;DDD:44068;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20144627-21266621;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21069662-21311925 0.2710 654499 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LOC646214 NR_027053 2 21932513 21940739 8226 0 0 no 1 txStart-txEnd UTR 21932513 21940739 DDD:44001;DDD:44096;DDD:44097;DDD:44098;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793;15:21904679-21949433;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44097;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21904679-21949433;15:21906623-22142846 0.1300 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 CXADRP2 NR_024387 1 22014402 22016878 2476 0 0 no 1 txStart-txEnd UTR 22014402 22016878 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 646243 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 POTEB NM_001277304 2 22051852 22083259 31407 1635 100 no 11 txStart-txEnd 5'UTR-3'UTR 22051852 22083259 DDD:44001;DDD:44096;DDD:44098;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793;15:21906623-22142846 0.3900 DDD:44001;DDD:44096;DDD:44098;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:21906623-22142846 0.1300 91.86 100996331 9 3.5277e-01 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 NF1P2 NR_028506 2 22133180 22145802 12622 0 0 no 8 txStart-txEnd UTR 22133180 22145802 DDD:44001;DDD:44096;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 440225 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 LINC02203 NR_152818 1 22195582 22199978 4396 0 0 no 3 txStart-txEnd UTR 22195582 22199978 DDD:44001;DDD:44096;TS40:ISCA-46686;dbVar;dgv2191n100;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:20388742-22207639;15:21399090-22661412;chr15:21885000-22208557;chr15:21885406-22211793 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 727924 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 OR4M2-OT1 NR_110480 1 22278030 22383564 105534 0 0 no 9 txStart-txEnd UTR 22278030 22383564 DDD:44001;DDD:44096;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752 0.3900 DDD:44001;DDD:44096;dgv40e203;dgv94e55;dgv96e55 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412 0.1300 690131;665411;669653;661973;681562;718266;688758;747790;701704;664511 loss 101927079 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 OR4M2 NM_001004719 2 22368477 22369561 1084 942 95 no 1 txStart-txEnd 5'UTR-3'UTR 22368477 22369561 1000g;DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv435e214;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22425022;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;chr15:22335841-22425022;chr15:22335841-22590413;chr15:22340286-22590413;chr15:22343965-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;15:22343966-22372302;chr15:22344732-22425022;15:22360686-22387071 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dbVar;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;chr15:22343965-22372302;15:22360686-22387071 0.1300 76.23 390538 9 3.9447e-08 full=1 +15_20564609_22409391_DEL_1 15 20564609 22409391 -1844782 DEL Benign NA split q11.2 OR4N4 NM_001005241 4 22382472 22383813 1341 951 100 no 1 txStart-txEnd 5'UTR-3'UTR 22382472 22383813 DDD:44001;DDD:44096;DDD:44106;DDD:44113;DDD:44114;DDD:44119;dbVar;dgv2191n100;dgv3e224;dgv40e203;dgv92e55;dgv93e55;nsv514767 15:20016329-23487546;15:20167087-22588036;15:20167087-22869764;15:20182203-22608281;15:20203950-22588019;15:21399090-22661412;chr15:22262252-22425022;chr15:22262252-22473149;chr15:22262252-22590413;15:22267463-22591752;15:22278200-22574827;chr15:22294059-22425022;chr15:22294059-22472949;chr15:22294059-22590413;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;chr15:22335841-22425022;chr15:22335841-22590413;chr15:22340286-22590413;chr15:22344732-22425022;15:22360686-22387071 0.4271 DDD:44001;DDD:44096;DDD:44113;DDD:44114;DDD:44119;dgv100e55;dgv2373n100;dgv40e203;dgv94e55;dgv96e55;nsv514767 15:20016329-23487546;15:20167087-23222284;15:20167090-22588036;15:20182203-22608281;15:21399090-22661412;15:22280466-22588019;15:22304657-22588026;15:22307890-22657533;15:22308418-22455534;15:22320058-22588019;15:22360686-22387071 0.1300 75.33 -0.271906921498889 -0.565772314050669 283694 9 5.1332e-05 1.8051e-02 full=1 +15_34735950_34806953_DEL_1 15 34735950 34806953 -71003 DEL Benign NA full q14 MIR1233-1 GOLGA8B 0 ACTC1 (morbid/RE=ABC_enhancer);RYR3 (morbid/RE=ABC_enhancer);SLC12A6 (morbid/RE=ABC_enhancer+EA_enhancer) dbVar:nssv15172447;dbVar:nssv15125410;dbVar:nssv15172190;dbVar:nssv15149616;dbVar:nssv15147411;dbVar:nssv15150618;nssv15150717;dbVar:nssv15151655;dbVar:nssv15145681 15:20016812-102493540;15:20063341-102521392;15:20071674-102461162;15:20733396-102511616;15:22765629-38837526;15:22770423-102429112;15:31115048-102354857;15:32899500-35492630 0.09;0.09;0.09;0.09;0.44;0.09;0.10;2.74 dbVar:nssv15147319;dbVar:nssv16208403;dbVar:nssv15127755;dbVar:nssv15148236;dbVar:nssv15127602;dbVar:nssv16208407;dbVar:nssv15154730;dbVar:nssv15146365;dbVar:nssv15146268;dbVar:nssv17976656;dbVar:nssv16208948;dbVar:nssv18788041 15:22698523-38381783;15:22770422-36861479;15:23622527-102521392;15:25279017-37496505;15:29209621-102521392;15:31675453-35689958;15:32446830-34868996;15:32618338-39686269;15:32928005-40526026;15:33809651-40027263;15:34197489-38656254;15:34526073-35087019 0.45;0.50;0.09;0.58;0.10;1.77;2.93;1.00;0.93;1.14;1.59;12.66 1000g;dbVar chr15:34705000-34821150;chr15:34721236-34836826;15:34721237-34836826 0.0144 1000g;DDD:44673;DDD:44674;HI40:ISCA-46481;HI40:ISCA-46482;dbVar;dgv2562n100;dgv313n27;dgv43e203;esv3636115;esv3892663;gnomAD-SV_v2.1_DEL_15_146738;gnomAD-SV_v2.1_DEL_15_146739;nsv517751 15:34647569-34871296;15:34674031-35008201;15:34674425-35009836;15:34678778-34862723;15:34710127-34856557;chr15:34710127-34856557;15:34710127-34856557;15:34714112-34830932;15:34718595-34807869;15:34718595-34871296;chr15:34721236-34836826;15:34721237-34836826;15:34721237-34836826;15:34726358-34872885;chr15:34726358-34872885;15:34726358-34872885 0.1680 chr15:34705000-34821150 dbVar;15:34721237-34836826 1000g;15:34741740-34742019 1000g;15:34764551-34764551 1000g;chr15:34783391-34800233 dbVar;chr15:34790329-34791917 dbVar;chr15:34796871-34800233 dbVar;chr15:34805510-34805809 dbVar;chr15:34805809-34807439 dbVar chr15:34700842-34794920 dbVar;chr15:34721236-34836826 dbVar;chr15:34725414-34781752 dbVar;chr15:34757312-34797576 dbVar;chr15:34781752-34783391 dbVar;chr15:34786870-34788046 dbVar;chr15:34791917-34796571 dbVar;chr15:34802630-35336031 dbVar;chr15:34805510-34816065 dbVar 15:34674031-35008201 DDD:44673;15:34678778-34862723 dgv43e203;chr15:34710127-34856557 dbVar;15:34714112-34830932 dgv2562n100;15:34718595-34807869 esv3892663;chr15:34721236-34836826 dbVar;15:34721237-34836826 esv3636115;chr15:34726358-34872885 dbVar;15:34741740-34742019 1000g;15:34741749-34742029 esv2678102;15:34741752-34742021 gnomAD-SV_v2.1_DEL_15_146741;chr15:34746988-34747300 dbVar;15:34779146-34783492 esv2667455;chr15:34785640-34786870 dbVar;15:34802473-34810922 1000g;15:34802548-34810836 DDD:44684;15:34802595-34810858 gnomAD-SV_v2.1_DEL_15_146744 15:34647569-34871296 nsv517751;15:34674425-35009836 DDD:44674;15:34710127-34856557 HI40:ISCA-46481;15:34710127-34856557 gnomAD-SV_v2.1_DEL_15_146738;15:34718595-34800595 dgv312n27;15:34718595-34871296 dgv313n27;15:34721237-34836826 1000g;15:34726358-34872885 HI40:ISCA-46482;15:34726358-34872885 gnomAD-SV_v2.1_DEL_15_146739;chr15:34741740-34742019 dbVar;chr15:34741752-34742021 dbVar;chr15:34743793-34743843 dbVar;15:34746988-34747300 gnomAD-SV_v2.1_DEL_15_146743;15:34779302-34783300 DDD:44682;chr15:34802472-34810922 dbVar;15:34802473-34810922 esv3636118;chr15:34802595-34810858 dbVar 177092;177093;29065;399343;175022;377509;379876;998882;10752;358334;456471;1026888;1027127;659804;298049;778754;2316987;1960483;1963174;2258547;335699;1675608;1880863;1091757;1285545;1305919;1410197;1489091;1977713;494211;718453;1876389;2561157 loss;gain 0.340 0.660 15:34730084-34776964 15:34782963-34820866;15:34800001-34813836 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (0 gene, +0.00);5F (+0.00) 1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA full p11.2 LOC107987382;TP53TG3;SLC6A10P;TP53TG3C;LOC105369266;TP53TG3B;LOC107987386 LOC390705 ENPP7P13 7 dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv16216874;dbVar:nssv15126545;dbVar:nssv15133058;dbVar:nssv15126469 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:5805002-34230001;16:24381954-33923059;16:30703234-35147508;16:31986099-90294753 1.13;1.13;1.13;1.13;1.13;3.57;10.65;22.86;1.74 dbVar:nssv15141243 16:28826163-34375007 18.31 DDD:47058;DDD:47062;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.0700 DDD:47058;DDD:47062;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028 0.0715 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 16:32055083-33851279 DDD:47058;16:32129166-32904510 DDD:47063;16:32345385-33344188 IMH;chr16:32452605-32490199 dbVar;chr16:32471402-32603879 dbVar;16:32473116-32486576 DDD:47080;16:32489448-32622550 dgv4e224;chr16:32490199-32627933 dbVar;chr16:32510679-32510887 dbVar;16:32589803-32684945 DDD:47091;16:32593538-32593538 1000g;chr16:32611029-32642738 dbVar;16:32611030-32642738 1000g;chr16:32651988-32942494 dbVar;16:32659200-32810000 gnomAD-SV_v2.1_DUP_16_42032;16:32664500-32696000 gnomAD-SV_v2.1_DUP_16_42034;16:32708700-32724200 gnomAD-SV_v2.1_DUP_16_42035;chr16:32740800-32750700 dbVar;16:32748500-32754000 gnomAD-SV_v2.1_DUP_16_42038;chr16:32831659-32863935 dbVar;16:32831660-32863935 1000g... 16:31749454-34012168 dgv50e203;16:32123333-33664028 DDD:47062;16:32257510-32714406 esv2421440;chr16:32379212-32490199 dbVar;chr16:32452605-32603879 dbVar;chr16:32471402-32942494 dbVar;16:32486529-32486871 DDD:47082;chr16:32490199-32603879 dbVar;chr16:32490199-32942494 dbVar;16:32511180-33912324 dgv821e212;chr16:32591655-32592550 dbVar;chr16:32603879-32651988 dbVar;16:32611030-32642738 1000g;16:32611030-32642738 dgv507e214;chr16:32656764-32657401 dbVar;16:32663000-32707000 gnomAD-SV_v2.1_DUP_16_42033;16:32684868-32688916 DDD:47098;16:32718500-32801100 gnomAD-SV_v2.1_DUP_16_42036;16:32740800-32750700 gnomAD-SV_v2.1_DUP_16_42037;16:32772000-32777000 gnomAD-SV_v2.1_DUP_16_42039;16:32831660-32863935 1000g... 16:32052946-32496748 DDD:47057;16:32123333-33664028 DDD:47062;16:32257510-32714406 esv2421440;chr16:32473466-32473664 dbVar;16:32485788-32648832 DDD:47081;16:32489448-32622550 dgv4e224;chr16:32494596-32496820 dbVar;chr16:32511665-32511727 dbVar;16:32524651-32525229 IMH;16:32532282-32533735 IMH;16:32562331-32601372 IMH;chr16:32586298-32586783 dbVar;16:32588181-32590788 1000g;16:32589803-32684945 DDD:47091;chr16:32598581-32602963 dbVar;16:32598582-32602963 esv3638436;16:32600138-32601847 IMH;16:32600306-32601869 1000g;16:32600344-32601845 IMH;chr16:32611029-32642738 dbVar;chr16:32618840-32618978 dbVar... 16:31749454-34012168 dgv50e203;16:32055083-33851279 DDD:47058;16:32129166-32904510 DDD:47063;16:32298051-32812316 DDD:47074;chr16:32485126-32485204 dbVar;16:32486808-32486871 DDD:47084;chr16:32491490-32496732 dbVar;16:32511180-32878155 dgv819e212;16:32518848-32519371 IMH;16:32525918-32525974 IMH;16:32541493-32648861 DDD:47087;16:32562341-32600296 IMH;chr16:32588180-32590788 dbVar;16:32588181-32590788 esv3638433;16:32590685-32653097 DDD:47092;16:32598582-32602963 1000g;chr16:32598863-32598991 dbVar;chr16:32600305-32601869 dbVar;16:32600306-32601869 esv3638437;16:32600531-32601385 IMH;chr16:32611994-32612297 dbVar... 648719;1019197;1024072;650740;664134;659810;662750;680372;700711;663041;687752;647804;669214;687945;678392;673066;650929;691320;677227;667456;685071;690589;682294;668120;652867;699971;679825;701586;690156;694132;664617;684688;668303;660676;681693;690990;670781;1020690;898894;655763;881905;818836;660363;674708;1024694;1024914;676793;1026893;1023636;819090;811320;... loss;gain 0.255 0.275 16:32471562-32471589 AT_rich 16:32328196-32493021;16:32333061-32489849;16:32333061-32492391;16:32462184-32472474 16:33363548-33517471;16:33465320-33517471;16:33466597-33509202 94.39 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (7 genes, +0.00);5F (+0.00) 1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 LOC107987382 NR_171659 1 32611681 32626892 15211 0 0 no 8 txStart-txEnd UTR 32611681 32626892 1000g;DDD:47058;DDD:47062;DDD:47063;DDD:47091;IMH;dbVar;dgv507e214;dgv50e203;dgv821e212;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32345385-33344188;chr16:32471402-32942494;chr16:32490199-32627933;chr16:32490199-32942494;16:32511180-33912324;16:32589803-32684945;chr16:32603879-32651988;chr16:32611029-32642738;16:32611030-32642738;16:32611030-32642738;16:32611030-32642738 0.8086 DDD:47058;DDD:47062;DDD:47063;DDD:47074;DDD:47081;DDD:47087;DDD:47091;DDD:47092;dbVar;dgv50e203;dgv819e212;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:32485788-32648832;16:32511180-32878155;16:32541493-32648861;16:32589803-32684945;16:32590685-32653097;chr16:32611029-32642738 0.2300 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 full=1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3 NM_016212 5 32684850 32687486 2636 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 32684850 32687486 DDD:47058;DDD:47062;DDD:47063;IMH;dbVar;dgv50e203;dgv821e212;esv2421440;gnomAD-SV_v2.1_DUP_16_42032;gnomAD-SV_v2.1_DUP_16_42033;gnomAD-SV_v2.1_DUP_16_42034 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32345385-33344188;chr16:32471402-32942494;chr16:32490199-32942494;16:32511180-33912324;chr16:32651988-32942494;16:32659200-32810000;16:32663000-32707000;16:32664500-32696000 0.3314 DDD:47058;DDD:47062;DDD:47063;DDD:47074;HI40:ISCA-46492;dbVar;dgv50e203;dgv819e212;esv2421440 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32257510-32714406;16:32298051-32812316;16:32511180-32878155;16:32656000-32802000;chr16:32656000-32802000 0.2300 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 94.39 24150 full=1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 SLC6A10P NR_003083 3 32888793 32896463 7670 0 0 no 9 txStart-txEnd UTR 32888793 32896463 DDD:47058;DDD:47062;DDD:47063;IMH;dbVar;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510;16:32345385-33344188;chr16:32471402-32942494;chr16:32490199-32942494;16:32511180-33912324;chr16:32651988-32942494 0.3314 DDD:47058;DDD:47062;DDD:47063;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32129166-32904510 0.1692 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 386757 full=1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3C NM_001205259 3 33205546 33208179 2633 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 33205546 33208179 DDD:47058;DDD:47062;DDD:47113;IMH;dbVar;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;chr16:33106071-33292140;16:33204449-33378738 0.3314 DDD:47058;DDD:47062;DDD:47113;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738 0.0715 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 91.96 653550 full=1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 LOC105369266 NR_158162 1 33215160 33232409 17249 0 0 no 6 txStart-txEnd UTR 33215160 33232409 DDD:47058;DDD:47062;DDD:47113;IMH;dbVar;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;chr16:33106071-33292140;16:33204449-33378738 0.3314 DDD:47058;DDD:47062;DDD:47113;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738 0.0715 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 full=1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 TP53TG3B NM_001099687 4 33262081 33264719 2638 375 100 no 2 txStart-txEnd 5'UTR-3'UTR 33262081 33264719 DDD:47058;DDD:47062;DDD:47113;DDD:47114;IMH;dbVar;dgv50e203;dgv821e212;gnomAD-SV_v2.1_DUP_16_42042 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;chr16:33106071-33292140;16:33204449-33378738;16:33230271-33739925;16:33237000-33295200 0.3314 DDD:47058;DDD:47062;DDD:47113;DDD:47114;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738;16:33230271-33739925 0.1243 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 92.24 729355 full=1 +16_32471626_33487672_DEL_1 16 32471626 33487672 -1016046 DEL Benign NA split p11.2 LOC107987386 NR_171660 1 33298270 33319296 21026 0 0 no 5 txStart-txEnd UTR 33298270 33319296 DDD:47058;DDD:47062;DDD:47113;DDD:47114;DDD:47116;IMH;dgv50e203;dgv821e212 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:32345385-33344188;16:32511180-33912324;16:33204449-33378738;16:33230271-33739925;16:33270420-33827235 0.5150 DDD:47058;DDD:47062;DDD:47113;DDD:47114;dgv50e203 16:31749454-34012168;16:32055083-33851279;16:32123333-33664028;16:33204449-33378738;16:33230271-33739925 0.1243 IMH 16:24121264-80276578;16:29238285-88227116;16:32354183-33512427;16:32354247-33512560 0.4996 full=1 +16_34493207_34702366_DUP_1 16 34493207 34702366 209159 DUP Benign NA full p11.1-p11.2 LINC01566 LOC112268173 FRG2DP 1 dbVar:nssv15158812;dbVar:nssv15148703;dbVar:nssv15150639;nssv15151292;dbVar:nssv15158813;dbVar:nssv15158224;dbVar:nssv15133058;dbVar:nssv15126469;dbVar:nssv15150356 16:61452-90294632;16:69194-90274381;16:85882-90155062;16:88166-90163275;16:88166-90274695;16:30703234-35147508;16:31986099-90294753;16:34197493-64509054 0.23;0.23;0.23;0.23;0.23;4.71;0.36;0.69 1000g;DDD:47173;DDD:47179;TS40:ISCA-37481;dbVar;dgv117e55;dgv2962n100;dgv51e203;dgv824e212;esv2421698;esv3638500;gnomAD-SV_v2.1_DUP_16_42078;nsv514804;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531;16:34441796-34784591;16:34445084-34774280;16:34456525-34736855;chr16:34456676-34760206;chr16:34457085-34712399;16:34457086-34712399;16:34457086-34712399;chr16:34465000-34757000;16:34465000-34757000;16:34470705-34757071;16:34471852-34731191;16:34476781-34747070 0.1875 HI40:ISCA-37481;dbVar 16:34202089-35147508;chr16:34457085-34712399 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 16:34197352-35283226 dgv51e203;16:34259806-34805859 nsv516385;16:34441796-34784591 dgv2962n100;16:34456525-34736855 DDD:47173;chr16:34457085-34712399 dbVar;16:34457086-34712399 esv3638500;16:34465000-34757000 gnomAD-SV_v2.1_DUP_16_42078;chr16:34468902-34546672 dbVar;16:34471852-34731191 nsv514804;chr16:34489945-34494742 dbVar;chr16:34500158-34528628 dbVar;chr16:34528628-34542969 dbVar;chr16:34542969-34544540 dbVar;chr16:34545266-34546672 dbVar;chr16:34546672-34548048 dbVar;chr16:34548048-34575188 dbVar;chr16:34548198-34564393 dbVar;chr16:34556315-34556698 dbVar;chr16:34565920-34575188 dbVar;chr16:34572795-34661165 dbVar;chr16:34573020-34575188 dbVar... chr16:34189000-34557000 dbVar;16:34202089-35147508 TS40:ISCA-37481;16:34410570-34796531 dgv117e55;16:34445084-34774280 dgv824e212;chr16:34456676-34760206 dbVar;16:34457086-34712399 1000g;chr16:34465000-34757000 dbVar;chr16:34468902-34494742 dbVar;16:34470705-34757071 esv2421698;16:34476781-34747070 DDD:47179;chr16:34492359-34494742 dbVar;chr16:34507956-34508548 dbVar;chr16:34528628-34544148 dbVar;chr16:34544540-34545266 dbVar;chr16:34545866-34548048 dbVar;chr16:34548048-34548198 dbVar;chr16:34548198-34550637 dbVar;chr16:34552087-34564393 dbVar;chr16:34565920-34571271 dbVar;16:34567146-34656231 DDD:47183;16:34572795-34661165 gnomAD-SV_v2.1_DUP_16_42081... chr16:34457085-34712399 dbVar;chr16:34513700-34518239 dbVar;chr16:34521342-34521422 dbVar;chr16:34530127-34530478 dbVar;chr16:34539678-34540320 dbVar;chr16:34563433-34571562 dbVar;chr16:34590029-34590133 dbVar;chr16:34590961-34591436 dbVar;chr16:34604209-34604282 dbVar;chr16:34659877-34659999 dbVar;chr16:34666766-34667080 dbVar;chr16:34687510-34703789 dbVar 16:34202089-35147508 HI40:ISCA-37481;chr16:34502223-34502386 dbVar;chr16:34515750-34515813 dbVar;chr16:34530038-34530588 dbVar;chr16:34539652-34540292 dbVar;16:34539693-34540322 DDD:47181;chr16:34568138-34568693 dbVar;chr16:34590565-34590648 dbVar;chr16:34600723-34610152 dbVar;chr16:34655648-34655724 dbVar;chr16:34664288-34664480 dbVar;chr16:34684662-34685228 dbVar 0.385 0.335 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);3A (1 gene, +0.00);5F (+0.00) 1 +16_34493207_34702366_DUP_1 16 34493207 34702366 209159 DUP Benign NA split p11.1-p11.2 LINC01566 NR_027080 2 34597786 34626084 28298 0 0 no 7 txStart-txEnd UTR 34597786 34626084 1000g;DDD:47173;DDD:47179;DDD:47183;TS40:ISCA-37481;dbVar;dgv117e55;dgv2962n100;dgv51e203;dgv824e212;esv2421698;esv3638500;gnomAD-SV_v2.1_DUP_16_42078;gnomAD-SV_v2.1_DUP_16_42081;nsv514804;nsv516385 16:34197352-35283226;16:34202089-35147508;16:34259806-34805859;16:34410570-34796531;16:34441796-34784591;16:34445084-34774280;16:34456525-34736855;chr16:34456676-34760206;chr16:34457085-34712399;16:34457086-34712399;16:34457086-34712399;chr16:34465000-34757000;16:34465000-34757000;16:34470705-34757071;16:34471852-34731191;16:34476781-34747070;16:34567146-34656231;chr16:34572795-34661165;16:34572795-34661165;chr16:34579398-34644534;chr16:34579398-34687954 0.1875 HI40:ISCA-37481;dbVar 16:34202089-35147508;chr16:34457085-34712399 0.01 IMH 16:24121264-80276578;16:29238285-88227116;16:34180655-46447887;16:34188883-46442460 0.4996 283914 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA full q12 TBC1D3B;CCL3L3;CCL4L2;TBC1D3I;CCL3L1;TBC1D3H;TBC1D3F CCL4 ZNHIT3 7 PEX12 (morbid/RE=GH_enhancer);PIGW (morbid/RE=EA_enhancer);ZNHIT3 (morbid/RE=ABC_enhancer+GH_enhancer) 17q12 recurrent (RCAD syndrome) region (includes HNF1B) dbVar:nssv15149908;nssv15152170;dbVar:nssv15159024;dbVar:nssv15160732;dbVar:nssv15159027;dbVar:nssv15127236;dbVar:nssv15775117;dbVar:nssv15132421;dbVar:nssv15132422;dbVar:nssv15155541;dbVar:nssv18330713;dbVar:nssv15155542;dbVar:nssv15605916;dbVar:nssv16736632;dbVar:nssv15138685;dbVar:nssv15142873;dbVar:nssv15141421;dbVar:nssv15132229;nssv15139703;dbVar:nssv15125411;dbVar:nssv15125622;dbVar:nssv15130152;nssv15132345;nssv15139691;dbVar:nssv15135915;dbVar:nssv15124805;dbVar:nssv18842005;TS3:ISCA-37432;dbVar:nssv15132164;dbVar:nssv17649867;dbVar:nssv16215252;dbVar:nssv15123756;dbVar:nssv15133519;dbVar:nssv16736603;dbVar:nssv15135870 17:527-81041938;17:7215-81058310;17:8548-81060040;17:12345-81057996;17:16757564-81048189;17:21690654-38772647;17:34310999-36297053;17:34360169-36209228;17:34425363-36283612;17:34425364-36404555;17:34426245-36225988;17:34437476-36214026;17:34437476-36243028;17:34437483-36244358;17:34437483-36350584;17:34437483-36404555;17:34508118-36248918;17:34526602-36188734;17:34604365-36231917;17:34611353-36248918;17:34611353-36263019;17:34750819-36354738;17:34752222-36105007;17:34815073-36192489;17:34815185-36209228;17:34815467-36249366;17:34815552-36244358;17:34815552-36249800;17:34817423-36173763;17:34817423-36243028;17:34817423-36248918 0.47;0.47;0.47;0.47;0.59;2.22;19.13;20.55;20.45;19.20;21.11;21.39;21.05;21.03;19.86;19.32;17.77;17.50;13.09;12.59;12.48;4.16;4.82;0.17;0.16;0.14;0.14;0.13;0.00;0.00;0.00 17q12 recurrent (RCAD syndrome) region (includes HNF1B) dbVar:nssv18830976;dbVar:nssv15137372;dbVar:nssv8639331;dbVar:nssv15142228;dbVar:nssv15133035;dbVar:nssv17976904;dbVar:nssv15142015;dbVar:nssv15153182;dbVar:nssv15153183;dbVar:nssv15133261;dbVar:nssv15124226;dbVar:nssv15132100;nssv15139544;dbVar:nssv15127168;dbVar:nssv15133024;dbVar:nssv17955818;HI3:ISCA-37432;dbVar:nssv15149164;dbVar:nssv15129143;dbVar:nssv15130784;nssv15172799;dbVar:nssv15173493;dbVar:nssv15131818;dbVar:nssv15135737;dbVar:nssv15135591;dbVar:nssv15134619 17:30572863-35843988;17:34360169-36248859;17:34360228-36473024;17:34447114-36283612;17:34450406-36248918;17:34463924-36410559;17:34475680-36283612;17:34475680-36311009;17:34477386-36404555;17:34508118-36173763;17:34604365-36188734;17:34611353-36248918;17:34750819-81048189;17:34768967-36263019;17:34807070-36284994;17:34815073-36192489;17:34815073-36192492;17:34815552-36208392;17:34815552-36244358;17:34815552-36307189;17:34817423-36168104;17:34817423-36188700;17:34817423-36248918;17:34817423-36263019 7.21;20.12;17.99;20.17;20.41;18.16;18.91;18.62;17.65;18.57;13.45;12.59;0.14;3.25;0.70;0.17;0.17;0.14;0.14;0.13;0.00;0.00;0.00;0.00 dgv122e55 17:34426246-34870708 0.0300 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 chr17:34405281-34480907 dbVar;17:34416412-34496071 nsv514836;17:34424712-34477480 dgv908e212;17:34426246-34870708 dgv122e55;17:34435513-34485079 dgv3148n100;17:34435674-34621060 DDD:49237;17:34436100-34482872 1000g;17:34436100-34482872 dgv572e214;chr17:34437000-34494000 dbVar;17:34437483-34477480 dgv910e212;chr17:34438389-34594251 dbVar;17:34443777-34537005 DDD:49243;chr17:34480907-34594251 dbVar;chr17:34493000-34503000 dbVar;17:34502930-34524195 nsv514837;17:34517741-34540630 DDD:49256;17:34580927-34587273 DDD:49263;chr17:34594251-34674805 dbVar;17:34625755-34641426 DDD:49271;chr17:34726651-34808825 dbVar;17:34750173-34796456 DDD:49284... 17:34387632-34629696 esv2762388;chr17:34405281-34674805 dbVar;17:34416538-34629684 dgv3144n100;17:34425364-34477387 dgv121e55;17:34431132-34484342 DDD:49235;17:34435513-34629696 esv2760467;chr17:34436099-34482872 dbVar;17:34436100-34482872 1000g;17:34436438-34780239 DDD:49240;17:34437129-34485091 esv2421587;chr17:34438389-34480907 dbVar;chr17:34438389-34666383 dbVar;chr17:34448629-34449060 dbVar;chr17:34480907-34674805 dbVar;chr17:34502750-34675848 dbVar;17:34502941-34524192 TS40:ISCA-46706;17:34538648-34540293 nsv514838;chr17:34594251-34657961 dbVar;17:34610042-34641487 nsv514839;chr17:34725848-34756800 dbVar;17:34746065-34746521 DDD:49283... 17:34438323-34449809 DDD:49242;chr17:34445826-34446140 dbVar;17:34508446-34554792 dgv545e199;17:34517741-34540630 DDD:49256;chr17:34540766-34540825 dbVar;17:34580927-34587273 DDD:49263;17:34625755-34641426 DDD:49271;chr17:34642332-34642392 dbVar;17:34702019-34702094 DDD:49280;17:34762644-34775639 DDD:49288;chr17:34812000-36251000 dbVar 17:34436438-34780239 DDD:49240;17:34443777-34537005 DDD:49243;17:34446621-34447535 DDD:49246;17:34509780-34551554 HI40:ISCA-46698;chr17:34528205-34528314 dbVar;17:34540766-34540825 gnomAD-SV_v2.1_DEL_17_159956;17:34591446-34670592 dgv546e199;chr17:34629804-34629885 dbVar;17:34642332-34642392 gnomAD-SV_v2.1_DEL_17_159958;17:34750173-34796456 DDD:49284;chr17:34808750-34815000 dbVar 650936;666192;914982;843056;871448;792583;651331;1008133;1008390;1008393;1008397;1008403;1008404;1008414;1008416;1008428;1008433;1008436;940419;987474;2208771;1314448;1320799;1505611;965332;831456;791549;1587115;878636;1428723;1966753;1241176;2242284;2563085;874577;1206030;1721282;2234627;1868520;2161178;2592993;823129;719980;897048;899422;920618;881956;607486;916148;602398;892138;... loss;gain 0.435 0.515 17:34437545-34437861 7SLRNA 17:34405992-34437446;17:34405992-34437446 94.43 2.42746656950142 2.41694262394586 yes 7 3.1517e-01 6.3692e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);3A (7 genes, +0.00);5F (+0.00) 1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3B NM_001001417 7 34493062 34503996 10934 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34493062 34503996 DDD:49237;DDD:49240;DDD:49243;dbVar;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34387632-34629696;chr17:34405281-34674805;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239;chr17:34438389-34594251;chr17:34438389-34666383;17:34443777-34537005;chr17:34480907-34594251;chr17:34480907-34674805 0.1041 DDD:49240;DDD:49243 17:34436438-34780239;17:34443777-34537005 0.0982 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 94.43 2.42746656950142 2.41694262394586 414059 7 2.1949e-01 6.3692e-01 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL3L3 NM_001001437 4 34522267 34524157 1890 282 100 no 3 txStart-txEnd 5'UTR-3'UTR 34522267 34524157 DDD:49237;DDD:49240;DDD:49243;DDD:49256;TS40:ISCA-46706;dbVar;dgv122e55;dgv3144n100;esv2760467;esv2762388;nsv514837 17:34387632-34629696;chr17:34405281-34674805;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239;chr17:34438389-34594251;chr17:34438389-34666383;17:34443777-34537005;chr17:34480907-34594251;chr17:34480907-34674805;chr17:34502750-34675848;17:34502930-34524195;17:34502941-34524192;17:34517741-34540630 0.1041 DDD:49240;DDD:49243;DDD:49256;HI40:ISCA-46698;dgv545e199 17:34436438-34780239;17:34443777-34537005;17:34508446-34554792;17:34509780-34551554;17:34517741-34540630 0.1500 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 88.85 414062 9 3.1517e-01 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL4L2 NM_001291471 2 34538464 34540275 1811 312 100 no 3 txStart-txEnd 5'UTR-3'UTR 34538464 34540275 DDD:49237;DDD:49240;DDD:49256;dbVar;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34387632-34629696;chr17:34405281-34674805;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239;chr17:34438389-34594251;chr17:34438389-34666383;chr17:34480907-34594251;chr17:34480907-34674805;chr17:34502750-34675848;17:34517741-34540630 0.0994 DDD:49240;DDD:49256;HI40:ISCA-46698;dgv545e199 17:34436438-34780239;17:34508446-34554792;17:34509780-34551554;17:34517741-34540630 0.1500 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 84.65 1.02068766819866 1.31010018701924 9560 9 8.8586e-02 4.8994e-01 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3I NM_001291463 2 34581084 34592039 10955 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34581084 34592039 DDD:49237;DDD:49240;dbVar;dgv122e55;dgv3144n100;esv2760467;esv2762388 17:34387632-34629696;chr17:34405281-34674805;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34435674-34621060;17:34436438-34780239;chr17:34438389-34594251;chr17:34438389-34666383;chr17:34480907-34594251;chr17:34480907-34674805;chr17:34502750-34675848 0.0994 DDD:49240 17:34436438-34780239 0.0982 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 414059 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 CCL3L1 NM_021006 5 34623841 34625731 1890 282 100 no 3 txStart-txEnd 5'UTR-3'UTR 34623841 34625731 DDD:49240;dbVar;dgv122e55;dgv3144n100;esv2760467;esv2762388;nsv514839 17:34387632-34629696;chr17:34405281-34674805;17:34416538-34629684;17:34426246-34870708;17:34435513-34629696;17:34436438-34780239;chr17:34438389-34666383;chr17:34480907-34674805;chr17:34502750-34675848;chr17:34594251-34657961;chr17:34594251-34674805;17:34610042-34641487 0.0994 DDD:49240;dgv546e199 17:34436438-34780239;17:34591446-34670592 0.1000 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 88.49 6349 yes 9 1.2057e-01 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3H NM_001123392 4 34746118 34757005 10887 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34746118 34757005 DDD:49240;dbVar;dgv122e55 17:34426246-34870708;17:34436438-34780239;chr17:34726651-34808825 0.0994 DDD:49240 17:34436438-34780239 0.0982 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 93.12 729877 full=1 +17_34437476_34817481_DUP_1 17 34437476 34817481 380005 DUP Benign NA split q12 TBC1D3F NM_032258 5 34797171 34808058 10887 1650 100 no 14 txStart-txEnd 5'UTR-3'UTR 34797171 34808058 dbVar;dgv122e55 17:34426246-34870708;chr17:34726651-34808825;chr17:34758000-34809000;chr17:34768932-34808825 0.0300 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508 0.2252 885243 gain 93.73 1.8673923772413 2.14567117504116 84218 9 1.3666e-05 6.2038e-01 full=1 +17_44171889_44297143_DUP_1 17 44171889 44297143 125254 DUP Benign NA full q21.31 KANSL1;KANSL1-AS1 STH ARL17B 2 GOSR2 (morbid/RE=ABC_enhancer+GH_enhancer);MAPT (morbid/RE=ABC_enhancer);NSF (morbid/RE=EA_enhancer);PLEKHM1 (morbid/RE=ABC_enhancer) dbVar:nssv15149908;nssv15152170;dbVar:nssv15159024;dbVar:nssv15160732;dbVar:nssv15159027;dbVar:nssv15127236;dbVar:nssv15149626;dbVar:nssv15150382;dbVar:nssv16207328;dbVar:nssv15141990 17:527-81041938;17:7215-81058310;17:8548-81060040;17:12345-81057996;17:16757564-81048189;17:42580685-81085615;17:43655357-44292742;17:43655357-44784639;17:43710151-44292742 0.15;0.15;0.15;0.15;0.19;0.33;18.96;11.09;20.74 Koolen-De Vries syndrome, 610443 (3) AD dbVar:nssv15127168;dbVar:nssv16215146;dbVar:nssv15141350;dbVar:nssv16254531;dbVar:nssv15124147;dbVar:nssv15135761;dbVar:nssv15137490;dbVar:nssv18330259;dbVar:nssv15129570;dbVar:nssv15138300;dbVar:nssv15137112;dbVar:nssv15132122;dbVar:nssv15132318;nssv15133093;dbVar:nssv15135170;dbVar:nssv15132284;nssv15139974;dbVar:nssv15136771;dbVar:nssv15136778;dbVar:nssv15132380;dbVar:nssv15173411;dbVar:nssv18329240;dbVar:nssv15133422;dbVar:nssv15143597;nssv15155552;dbVar:nssv15138826;dbVar:nssv15142266;nssv17976955;nssv18326376;dbVar:nssv15173506;dbVar:nssv15136011;dbVar:nssv15133428;dbVar:nssv15132370;nssv15140010;dbVar:nssv15132745;dbVar:nssv16091744;dbVar:nssv15135222;dbVar:nssv15161495;dbVar:nssv15129007;dbVar:nssv15152077;dbVar:nssv15132384;dbVar:nssv15136234;dbVar:nssv15132385;dbVar:nssv15133429;morbid:KANSL1;HI3:KANSL1;dbVar:nssv16252231 17:34750819-81048189;17:43559852-44248220;17:43585761-44248995;17:43586397-44212416;17:43592411-44249054;17:43593477-44224221;17:43622198-44201470;17:43622198-44212416;17:43629216-44399455;17:43648492-44214888;17:43651732-44351152;17:43653228-44351644;17:43655748-44176717;17:43655748-44224221;17:43655748-44351152;17:43656694-44176717;17:43656694-44694311;17:43675409-44351152;17:43685926-44212727;17:43693539-44212416;17:43693608-44176717;17:43703801-44212416;17:43703802-44187492;17:43703802-44212416;17:43705602-44208333;17:43706887-44171947;17:43706887-44176171;17:43706887-44176717;17:43706887-44207977;17:43706887-44210822;17:43706887-44351152;17:43706887-44694283;17:43706896-44762543;17:43710371-44212416;17:43715081-44176717;17:43717704-44345038;17:43717704-44351152;17:43751675-44351152;17:44107282-44302733;17:44107283-44302740;17:44174220-44481307 0.27;11.09;11.63;6.47;11.75;8.30;5.11;6.87;16.26;7.59;17.91;17.93;0.93;9.21;18.01;0.93;12.07;18.54;7.75;7.81;1.00;7.97;3.23;7.97;7.25;0.01;0.91;1.03;7.20;7.73;19.44;12.69;11.87;8.07;1.05;19.97;19.77;20.89;64.08;64.08;40.03 22 Inborn_genetic_diseases;Intellectual_disability;Koolen-de_Vries_syndrome;Neurodevelopmental_delay DDD:49604;IMH;dbVar;dgv127e55;dgv128e55;dgv3181n100;esv2422002;esv2762433;nsv516807 17:43574135-44788194;17:43655786-44366714;17:44004973-44811116;17:44094472-44364056;17:44109475-44793283;chr17:44139347-44410871;17:44145590-44364158;chr17:44165250-44337661;chr17:44165250-44410871;17:44165804-44362009;17:44170038-44744285 0.1700 esv2762433 17:43574135-44788194 0.0700 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508;17:43662689-44338152;17:43664434-44336296;17:43681870-44318931 0.2252 17:43655786-44366714 IMH;17:44094472-44364056 dgv128e55;chr17:44139347-44410871 dbVar;17:44149791-44248860 DDD:49602;chr17:44165000-44217000 dbVar;chr17:44165250-44337661 dbVar;chr17:44165338-44211686 dbVar;17:44165339-44211686 1000g;17:44165703-44291551 nsv514850;17:44170038-44744285 DDD:49604;17:44175518-44443972 DDD:49608;17:44176859-44397890 DDD:49609;17:44187493-44292742 dgv938e212;17:44187493-44789621 dgv939e212;17:44208145-44764994 esv2760451;chr17:44208362-44787272 dbVar;17:44212647-44369642 IMH;17:44212745-44369562 gnomAD-SV_v2.1_DUP_17_44188;17:44223908-44224221 1000g;chr17:44224197-44224935 dbVar;17:44230894-44262697 1000g... 17:43574135-44788194 esv2762433;17:44004973-44811116 dgv127e55;17:44109475-44793283 nsv516807;17:44145590-44364158 dgv3181n100;17:44163926-44293020 dgv367n27;17:44165000-44217000 gnomAD-SV_v2.1_DUP_17_44187;chr17:44165250-44410871 dbVar;17:44165339-44211686 1000g;17:44165339-44211686 dgv575e214;17:44165804-44362009 esv2422002;17:44170285-44212803 DDD:49606;17:44176395-44176717 1000g;17:44187493-44214094 dgv937e212;17:44187493-44364056 dgv130e55;17:44194107-44762405 DDD:49611;chr17:44208362-44406622 dbVar;17:44209763-44267388 DDD:49612;chr17:44212745-44369562 dbVar;17:44212825-44276618 dgv943e212;chr17:44223933-44224949 dbVar;chr17:44230893-44262697 dbVar... 17:44170285-44212803 DDD:49606;chr17:44176395-44176717 dbVar;chr17:44176407-44176807 dbVar;17:44176859-44397890 DDD:49609;17:44190672-44785015 dgv940e212;chr17:44192997-44193064 dbVar;17:44208145-44764994 esv2760451;chr17:44223760-44224221 dbVar;17:44223908-44224221 1000g;17:44223908-44224221 esv2662030;chr17:44265262-44265312 dbVar; 17:43574135-44788194 esv2762433;17:44176395-44176717 1000g;17:44176395-44176717 esv2675570;17:44176407-44176807 gnomAD-SV_v2.1_DEL_17_160649;chr17:44179666-44182382 dbVar;chr17:44192422-44192507 dbVar;17:44194107-44762405 DDD:49611;17:44212311-44292742 dgv941e212;17:44223760-44224221 gnomAD-SV_v2.1_DEL_17_160652;chr17:44223908-44224221 dbVar;chr17:44256597-44256681 dbVar;chr17:44278890-44279167 dbVar 992416;992452;992460;971439;2822283;936188;699111;763559;763560;1997544;2228707;2896576;3037823;1274013;2348966;933569;2715621;989025;2410443;70215;987476;453497;942828;2644184;1145788;1665693;1853738;2618991;2839546;2972078;2976287;688566;1021567;1021568;663556;1248933;3054208;1140557;1022169;2074112;2606291;1357512;1134448;2027524;2282991;667879;670841;2478215;2750031;3067029;468614;... loss;gain 0.380 0.460 17:44297188-44297495 AluY 17:44164882-44183555 17:44294406-44329730 3 16.23 -0.71959827485963 0.443929223699058 612452 yes 0 9.9972e-01 9.9973e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2I-3 (KANSL1, +0.00);3A (2 genes, +0.00);5F (+0.00) 1 +17_44171889_44297143_DUP_1 17 44171889 44297143 125254 DUP Benign NA split q21.31 KANSL1 NM_001193465 2 44107281 44302733 125255 1431 43 no 16 intron2-intron4 5'UTR-CDS 37 5' 44171888 44297143 22 Inborn_genetic_diseases;Intellectual_disability;Koolen-de_Vries_syndrome;Neurodevelopmental_delay DDD:49604;IMH;dbVar;dgv127e55;dgv128e55;dgv3181n100;esv2422002;esv2762433;nsv516807 17:43574135-44788194;17:43655786-44366714;17:44004973-44811116;17:44094472-44364056;17:44109475-44793283;chr17:44139347-44410871;17:44145590-44364158;chr17:44165250-44337661;chr17:44165250-44410871;17:44165804-44362009;17:44170038-44744285 0.1700 esv2762433 17:43574135-44788194 0.0700 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508;17:43662689-44338152;17:43664434-44336296;17:43681870-44318931 0.2252 992416;992452;992460;971439;2822283;936188;699111;763559;763560;1997544;2228707;2896576;3037823;1274013;2348966;933569;2715621;989025;2410443;70215;987476;453497;942828;2644184;1145788;1665693;1853738;2618991;2839546;2972078;2976287;688566;1021567;1021568;663556;1248933;3054208;1140557;1022169;2074112;2606291;1357512;1134448;2027524;2282991;667879;670841;2478215;2750031;3067029;468614;... loss;gain 3 0 16.23 -0.71959827485963 0.443929223699058 Koolen-de Vries syndrome;Koolen-de Vries syndrome due to a point mutation AD Definitive;Strong;Supportive 22544363;22544363[PMID]_22544367[PMID]_20301783[PMID];22544367 284058 612452 Koolen-De Vries syndrome, 610443 (3) AD AD yes 0 9.9972e-01 9.9973e-01 full=1 +17_44171889_44297143_DUP_1 17 44171889 44297143 125254 DUP Benign NA split q21.31 KANSL1-AS1 NR_034172 1 44270938 44274089 3151 0 0 no 2 txStart-txEnd UTR 44270938 44274089 DDD:49604;DDD:49608;DDD:49609;DDD:49611;DDD:49618;IMH;dbVar;dgv127e55;dgv128e55;dgv130e55;dgv3181n100;dgv367n27;dgv938e212;dgv939e212;dgv943e212;esv2422002;esv2760451;esv2762433;gnomAD-SV_v2.1_DUP_17_44188;nsv514850;nsv516807 17:43574135-44788194;17:43655786-44366714;17:44004973-44811116;17:44094472-44364056;17:44109475-44793283;chr17:44139347-44410871;17:44145590-44364158;17:44163926-44293020;chr17:44165250-44337661;chr17:44165250-44410871;17:44165703-44291551;17:44165804-44362009;17:44170038-44744285;17:44175518-44443972;17:44176859-44397890;17:44187493-44292742;17:44187493-44364056;17:44187493-44789621;17:44194107-44762405;17:44208145-44764994;chr17:44208362-44406622;chr17:44208362-44787272;17:44212647-44369642;chr17:44212745-44369562;17:44212745-44369562;17:44212825-44276618;17:44249111-44320939 0.5406 DDD:49609;DDD:49611;dgv940e212;dgv941e212;esv2760451;esv2762433 17:43574135-44788194;17:44176859-44397890;17:44190672-44785015;17:44194107-44762405;17:44208145-44764994;17:44212311-44292742 0.2994 IMH 17:30436599-65922464;17:32367054-60556542;17:32367223-60556516;17:32367435-60556508;17:43662689-44338152;17:43664434-44336296;17:43681870-44318931;17:43702611-44296817 0.2252 644246 full=1 +2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA full q37.3 LINC01237;LINC01238;LOC285097;LINC01880 FAM240C LINC01881 4 AGXT (morbid/RE=ABC_enhancer);D2HGDH (morbid/RE=ABC_enhancer+EA_enhancer+GH_enhancer);DTYMK (morbid/RE=ABC_enhancer+EA_enhancer) dbVar:nssv17976961;dbVar:nssv15174359;dbVar:nssv15174602;dbVar:nssv16254741;dbVar:nssv15147151;dbVar:nssv15147318;dbVar:nssv15146760;dbVar:nssv15121191;dbVar:nssv15134347;dbVar:nssv15120707;dbVar:nssv8639299 2:2-243199373;2:14239-243048760;2:15673-243101834;2:178397960-243007457;2:189682922-243007359;2:211444401-243059659;2:218966483-243059659;2:228667865-243028452;2:236177413-243059659;2:236472309-243028452;2:239873382-243006013 0.07;0.07;0.07;0.22;0.27;0.51;0.67;1.13;2.36;2.48;4.47 2q37.3 terminal region (includes HDAC4) dbVar:nssv15124851;dbVar:nssv15132233;nssv15140017;dbVar:nssv16296940;dbVar:nssv15139807;dbVar:nssv15126959;dbVar:nssv15121136;dbVar:nssv15120661;dbVar:nssv15121139;dbVar:nssv15132363;dbVar:nssv15121140;dbVar:nssv15134903;dbVar:nssv15122404;dbVar:nssv15133611;dbVar:nssv15120667;dbVar:nssv16865882;dbVar:nssv15137653;dbVar:nssv15132686;dbVar:nssv17976287;dbVar:nssv15136836;dbVar:nssv15133934;dbVar:nssv15133750;dbVar:nssv15163370;dbVar:nssv15134792;dbVar:nssv15133170;dbVar:nssv15132355;dbVar:nssv15605955;dbVar:nssv15137339;dbVar:nssv15605956;dbVar:nssv18326326;dbVar:nssv15136036;dbVar:nssv15755694;HI3:ISCA-37394;dbVar:nssv15121144;dbVar:nssv15135054;dbVar:nssv15133743;dbVar:nssv15135857;dbVar:nssv15120673;dbVar:nssv15133620;dbVar:nssv15122695;dbVar:nssv15163383;dbVar:nssv16207882;dbVar:nssv15141519;dbVar:nssv15121145 2:50886433-243102476;2:232634990-243059659;2:233110453-243028452;2:233784244-243040217;2:233891214-243068334;2:233995841-243028452;2:234362258-243041306;2:235081181-243028452;2:235254487-243059659;2:235576804-243059659;2:235744425-243007359;2:235937074-243008259;2:236177413-243007359;2:236649724-242974607;2:237201757-243048760;2:237322366-243059659;2:237463877-243059659;2:237619066-243048655;2:237684406-243059659;2:237875407-243007359;2:237943120-243007359;2:238037760-243101834;2:238140848-243007359;2:238434828-242938241;2:238552640-243059659;2:238795603-242918203;2:238811513-243059659;2:239071624-243048760;2:239229305-243199373;2:239742161-243059659;2:239894073-243048760;2:239954694-242930600;2:241006624-243028452;2:241006624-243059659;2:241110555-243007359;2:241127319-243059659;2:241384237-243028452;2:241446569-243007359;2:241610649-243034277;2:241847590-243101834;2:242011634-243199373;2:242045570-243040217;2:242188711-243028452 0.08;1.56;1.64;1.76;1.77;1.80;1.87;2.05;2.08;2.17;1.95;2.01;2.07;1.72;2.78;2.83;2.90;2.99;3.02;2.76;2.79;3.21;2.91;1.61;3.61;1.27;3.83;4.09;4.09;4.90;5.15;2.17;8.04;7.92;7.46;8.41;9.89;9.06;11.42;12.96;13.68;16.34;19.35 dbVar chr2:242759086-243061064 0.01 DDD:9221;DDD:9222;IMH;dbVar;gnomAD-SV_v2.1_DEL_2_28790 2:242849685-243064401;chr2:242852582-243035504;chr2:242853252-243035778;2:242853252-243035778;2:242853253-243035778;2:242853253-243035778 0.0686 chr2:242759086-243061064 dbVar;chr2:242830051-242941344 dbVar;2:242869276-242871593 IMH;chr2:242881412-242881978 dbVar;chr2:242890091-242926595 dbVar;chr2:242928580-242929253 dbVar;chr2:242945609-242946126 dbVar;chr2:242948000-242953000 dbVar;chr2:242953041-242994310 dbVar;chr2:242955091-242989460 dbVar;chr2:242960191-242960274 dbVar;chr2:242964220-242964715 dbVar;chr2:242966528-242967434 dbVar;chr2:242968350-243042956 dbVar;chr2:242972195-242973743 dbVar;chr2:242975102-242975433 dbVar;chr2:242986081-242986179 dbVar;2:242988770-243037176 1000g;chr2:242990734-242996703 dbVar;chr2:242998333-242998483 dbVar;chr2:243009492-243020902 dbVar... chr2:242743183-242871121 dbVar;chr2:242806389-242941416 dbVar;chr2:242867459-242867538 dbVar;chr2:242869973-242871147 dbVar;chr2:242889607-242924507 dbVar;chr2:242894433-242907894 dbVar;2:242930601-243102476 TS40:ISCA-37470;chr2:242945609-242946430 dbVar;chr2:242950077-242950601 dbVar;chr2:242953164-242954423 dbVar;chr2:242955205-242959025 dbVar;chr2:242960459-242968350 dbVar;chr2:242964221-242964720 dbVar;chr2:242968350-242974721 dbVar;chr2:242971430-242983239 dbVar;chr2:242974721-242986550 dbVar;chr2:242983442-243003523 dbVar;chr2:242988769-243037176 dbVar;2:242988770-243037176 dgv768e214;chr2:242990734-243008570 dbVar;chr2:242998483-243000882 dbVar... 2:242702555-243025545 DDD:9211;chr2:242851168-242874365 dbVar;2:242851169-242874365 esv3594848;chr2:242852582-243035504 dbVar;2:242852907-242902712 1000g;chr2:242853243-243019021 dbVar;2:242853244-243019021 esv3594850;2:242853252-243035778 gnomAD-SV_v2.1_DEL_2_28790;2:242853253-243035778 IMH;chr2:242860574-242892107 dbVar;2:242860575-242892107 esv3594851;2:242872863-243012181 HI40:ISCA-46585;chr2:242878551-242885258 dbVar;2:242881805-242896360 1000g;2:242881806-242896359 DDD:9229;chr2:242888545-242889711 dbVar;2:242890092-242926595 1000g;chr2:242895812-242954423 dbVar;2:242898343-242898462 1000g;chr2:242912279-242912530 dbVar;2:242915467-243089456 dgv90e203... 2:242516106-243014630 dgv165e55;2:242849685-243064401 DDD:9221;2:242851169-242874365 1000g;chr2:242852582-242959025 dbVar;chr2:242852906-242902712 dbVar;2:242852907-242902712 esv3594849;2:242853244-243019021 1000g;chr2:242853252-243035778 dbVar;2:242853253-243035778 DDD:9222;chr2:242854838-242867434 dbVar;2:242860575-242892107 1000g;2:242867313-242921118 DDD:9226;chr2:242874439-243024795 dbVar;chr2:242881804-242896360 dbVar;2:242881805-242896360 esv3594852;chr2:242887570-243070660 dbVar;chr2:242890091-242926595 dbVar;2:242890092-242926595 esv3594853;chr2:242898332-242898462 dbVar;chr2:242898343-242898462 dbVar;2:242915455-243049013 dgv4203n100... 0.400 0.460 2:243007680-243062019 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (4 genes, +0.00);5F (+0.00) 1 +2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LINC01237 NR_110220 1 242823513 243020873 154953 0 0 no 4 intron2-txEnd UTR 41134 5' 242865920 243020873 dbVar chr2:242759086-243061064 0.01 DDD:9211;DDD:9221;DDD:9222;IMH;dbVar;gnomAD-SV_v2.1_DEL_2_28790 2:242702555-243025545;2:242849685-243064401;chr2:242852582-243035504;chr2:242853252-243035778;2:242853252-243035778;2:242853253-243035778;2:242853253-243035778 0.0686 101927289 full=1 +2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LINC01238 NR_110592 1 242912833 242919427 6594 0 0 no 6 txStart-txEnd UTR 242912833 242919427 dbVar chr2:242759086-243061064;chr2:242806389-242941416;chr2:242830051-242941344;chr2:242889607-242924507;chr2:242890091-242926595 0.01 1000g;DDD:9211;DDD:9221;DDD:9222;DDD:9226;HI40:ISCA-46585;IMH;dbVar;dgv165e55;esv3594850;esv3594853;gnomAD-SV_v2.1_DEL_2_28790 2:242516106-243014630;2:242702555-243025545;2:242849685-243064401;chr2:242852582-242959025;chr2:242852582-243035504;chr2:242853243-243019021;2:242853244-243019021;2:242853244-243019021;chr2:242853252-243035778;2:242853252-243035778;2:242853253-243035778;2:242853253-243035778;2:242867313-242921118;2:242872863-243012181;chr2:242874439-243024795;chr2:242887570-243070660;chr2:242890091-242926595;2:242890092-242926595;2:242890092-242926595;chr2:242895812-242954423 0.0686 102723927 full=1 +2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LOC285097 NR_149023 1 242943359 242948164 4805 0 0 no 1 txStart-txEnd UTR 242943359 242948164 TS40:ISCA-37470;dbVar chr2:242759086-243061064;2:242930601-243102476 0.01 1000g;DDD:9211;DDD:9221;DDD:9222;DDD:9231;DDD:9235;HI40:ISCA-37470;HI40:ISCA-46585;IMH;dbVar;dgv165e55;dgv167e55;dgv4203n100;dgv498n27;dgv90e203;esv3594850;esv3594855;gnomAD-SV_v2.1_DEL_2_28790 2:242516106-243014630;2:242702555-243025545;2:242849685-243064401;chr2:242852582-242959025;chr2:242852582-243035504;chr2:242853243-243019021;2:242853244-243019021;2:242853244-243019021;chr2:242853252-243035778;2:242853252-243035778;2:242853253-243035778;2:242853253-243035778;2:242872863-243012181;chr2:242874439-243024795;chr2:242887570-243070660;chr2:242895812-242954423;2:242915455-243049013;2:242915467-243089456;2:242917307-243044147;chr2:242918208-242948232;2:242918249-243014630;chr2:242919210-242952227;2:242919211-242952227;2:242919211-242952227;2:242919289-242952148;2:242922232-243083979;2:242930601-243102476;chr2:242933537-242959025;chr2:242936128-242980024;chr2:242938726-242952779;chr2:242941934-242955439 0.0804 full=1 +2_242865921_243028452_DEL_1 2 242865921 243028452 -162531 DEL Benign NA split q37.3 LINC01880 NR_146651 1 242989834 243026289 36455 0 0 no 4 txStart-txEnd UTR 242989834 243026289 1000g;TS40:ISCA-37470;dbVar;dgv768e214 chr2:242759086-243061064;2:242930601-243102476;chr2:242968350-243042956;chr2:242988769-243037176;2:242988770-243037176;2:242988770-243037176 0.0951 1000g;DDD:9221;DDD:9222;DDD:9235;HI40:ISCA-37470;IMH;dbVar;dgv4203n100;dgv498n27;dgv90e203;esv3594857;esv3594864;gnomAD-SV_v2.1_DEL_2_28790 2:242849685-243064401;chr2:242852582-243035504;chr2:242853252-243035778;2:242853252-243035778;2:242853253-243035778;2:242853253-243035778;chr2:242887570-243070660;2:242915455-243049013;2:242915467-243089456;2:242917307-243044147;2:242922232-243083979;2:242930601-243102476;chr2:242944058-243035710;2:242944059-243035710;2:242944059-243035710;chr2:242988769-243037176;2:242988770-243037176;2:242988770-243037176 0.0804 105373979 full=1 +3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA full q29 MIR570HG;MIR570;MUC20 SDHAP2 MUC4 3 ABCB7 (morbid/RE=mTL_miRNA);ABHD5 (morbid/RE=mTL_miRNA);ADAM22 (morbid/RE=mTL_miRNA);ANXA11 (morbid/RE=mTL_miRNA);ATP6V1B2 (morbid/RE=mTL_miRNA);BICD2 (morbid/RE=mTL_miRNA);BTD (morbid/RE=mTL_miRNA);CALM1 (morbid/RE=mTL_miRNA);CALM3 (morbid/RE=mTL_miRNA);CAVIN1 (morbid/RE=mTL_miRNA);CBFB (morbid/RE=mTL_miRNA);CCDC115 (morbid/RE=mTL_miRNA);CDKN1B (HI=3/morbid/RE=mTL_miRNA);CHD1 (morbid/RE=mTL_miRNA);CHSY1 (morbid/RE=mTL_miRNA);CLCN3 (morbid/RE=mTL_miRNA);CRTAP (morbid/RE=mTL_miRNA);CSNK2A1 (morbid/RE=mTL_miRNA);DDHD1 (morbid/RE=mTL_miRNA);ELOVL5 (morbid/RE=mTL_miRNA);EPG5 (morbid/RE=mTL_miRNA);ESCO2 (morbid/RE=mTL_miRNA);EXOC2 (morbid/RE=mTL_miRNA);FBXW7 (morbid/RE=mTL_miRNA);FTH1 (morbid/RE=mTL_miRNA);GDF6 (morbid/RE=mTL_miRNA);GSR (morbid/RE=mTL_miRNA);IGF1R (HI=3/morbid/RE=mTL_miRNA);IL6R (morbid/RE=mTL_miRNA);IREB2 (morbid/RE=mTL_miRNA);KCNB1 (morbid/RE=mTL_miRNA);KLHL15 (morbid/RE=mTL_miRNA);KREMEN1 (morbid/RE=mTL_miRNA);LEMD2 (morbid/RE=mTL_miRNA);MRPL3 (morbid/RE=mTL_miRNA);MYO1C (morbid/RE=mTL_miRNA);NDRG1 (morbid/RE=mTL_miRNA);NDUFA12 (morbid/RE=mTL_miRNA);P3H2 (morbid/RE=mTL_miRNA);PAX2 (HI=3/morbid/RE=mTL_miRNA);PCYT1A (morbid/RE=GH_enhancer);PEX2 (morbid/RE=mTL_miRNA);PGK1 (morbid/RE=mTL_miRNA);PHF6 (HI=3/morbid/RE=mTL_miRNA);RAC1 (morbid/RE=mTL_miRNA);RNF168 (morbid/RE=GH_enhancer);SAMD12 (morbid/RE=mTL_miRNA);SETD5 (HI=3/morbid/RE=mTL_miRNA);SMC5 (morbid/RE=mTL_miRNA);SOX3 (morbid/RE=mTL_miRNA);TACR3 (morbid/RE=mTL_miRNA);TFRC (morbid/RE=ABC_enhancer+EA_enhancer);TGFBR2 (morbid/RE=mTL_miRNA);TNFRSF10B (morbid/RE=mTL_miRNA);TPM3 (morbid/RE=mTL_miRNA);TRIP13 (morbid/RE=mTL_miRNA);VMA21 (morbid/RE=mTL_miRNA);WARS2 (morbid/RE=mTL_miRNA);ZBTB18 (HI=3/morbid/RE=mTL_miRNA) dbVar:nssv15162889;dbVar:nssv15164144;dbVar:nssv15149891;nssv15151839;dbVar:nssv15148025;dbVar:nssv15146977;dbVar:nssv15145927;dbVar:nssv15147555;dbVar:nssv15147518;dbVar:nssv15145707;dbVar:nssv15149548;dbVar:nssv15148262;dbVar:nssv15146719;dbVar:nssv18326383;dbVar:nssv15164224;dbVar:nssv15147464;dbVar:nssv15148839;dbVar:nssv15142547;dbVar:nssv15153539;dbVar:nssv17976740;dbVar:nssv15153542;dbVar:nssv15153544;dbVar:nssv15164241;dbVar:nssv15152868;dbVar:nssv15755821;dbVar:nssv15146377;dbVar:nssv15146980;dbVar:nssv15153546;dbVar:nssv15145873;dbVar:nssv15149008;dbVar:nssv15145905;dbVar:nssv15146981;dbVar:nssv16254509;dbVar:nssv16736615;dbVar:nssv15148110 3:60175-197948027;3:61496-197838262;3:61893-197851986;3:103145727-197837049;3:147239680-197823436;3:151818302-197845254;3:155836231-197851986;3:156039668-197840323;3:157011168-197861598;3:158980632-197766890;3:165854998-197851986;3:167885357-197837049;3:171549422-198022430;3:173281267-197838262;3:175886314-197845254;3:176157700-197845254;3:177246494-197837049;3:182539235-197851986;3:183498521-197851986;3:184003968-197851986;3:186374366-197851986;3:186374672-197838262;3:187913568-197851986;3:188386567-197838262;3:188983161-197837049;3:190385453-197837049;3:191593620-197851986;3:192470727-197845254;3:193422395-197851986;3:194013987-197837069;3:194145226-197895629;3:195068029-197851986;3:195419169-197387258;3:195438670-197837049 0.03;0.03;0.03;0.06;0.11;0.12;0.13;0.13;0.13;0.14;0.17;0.18;0.20;0.22;0.24;0.25;0.26;0.35;0.37;0.39;0.47;0.47;0.54;0.57;0.61;0.72;0.86;1.00;1.21;1.40;1.43;1.93;2.73;1.43 dbVar:nssv15146266;dbVar:nssv15128822;dbVar:nssv15165459;dbVar:nssv17955845;dbVar:nssv17955930;dbVar:nssv15145831 3:185203638-197837049;3:185599935-196462295;3:189101447-197838262;3:189608637-197532175;3:191866467-197842171;3:194059264-197420612 0.42;0.49;0.61;0.68;0.90;1.60 DDD:12528;TS40:ISCA-46592;dbVar;esv2760775;esv2763776 3:195240825-195502119;chr3:195272344-195742942;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;chr3:195398446-195473245 0.0300 DDD:12528;esv2760775;esv2763776 3:195240825-195502119;3:195383143-195502119;3:195385823-195474165 0.0300 IMH 3:195371562-197367616;3:195376259-197363816;3:195409822-195693354;3:195413625-195689159;3:195417390-195684632;3:195418302-195683569 0.1142 chr3:195272344-195742942 dbVar;chr3:195340839-195456934 dbVar;3:195383143-195502119 esv2760775;chr3:195398446-195473245 dbVar;chr3:195417835-195445776 dbVar;3:195417836-195445776 1000g;3:195417836-195445776 1000g;3:195428197-195442889 nsv515001;chr3:195452000-195457000 dbVar;3:195452013-195457240 1000g;3:195452013-195457240 dgv968e214;chr3:195453277-195475056 dbVar;chr3:195456053-195466565 dbVar;chr3:195457000-195471300 dbVar;chr3:195457000-195550000 dbVar;3:195457142-195468593 1000g;3:195457142-195468593 dgv969e214;chr3:195457816-195472945 dbVar;chr3:195471000-195476300 dbVar 3:195240825-195502119 esv2763776;3:195320057-195470538 DDD:12519;3:195376589-195493533 TS40:ISCA-46592;3:195385823-195474165 DDD:12528;3:195417631-195471708 DDD:12530;3:195417836-195445776 1000g;3:195417836-195445776 1000g;3:195417836-195445776 dgv967e214;3:195429509-195429624 gnomAD-SV_v2.1_DUP_3_10620;chr3:195452012-195457240 dbVar;3:195452013-195457240 1000g;chr3:195453277-195456053 dbVar;3:195454692-195475463 DDD:12537;chr3:195456053-195475056 dbVar;3:195457000-195471300 gnomAD-SV_v2.1_DUP_3_10621;chr3:195457141-195468593 dbVar;3:195457142-195468593 1000g;chr3:195457285-195471001 dbVar;chr3:195466565-195475056 dbVar 3:195320057-195470538 DDD:12519;3:195383131-195446910 dgv5017n100;3:195385823-195474165 DDD:12528;chr3:195425199-195425686 dbVar;3:195454692-195475463 DDD:12537;3:195457142-195471062 dgv970e214;chr3:195457317-195471062 dbVar;chr3:195463643-195463762 dbVar 3:195240825-195502119 esv2763776;3:195380279-195469564 HI40:ISCA-46589;3:195383143-195502119 esv2760775;3:195417631-195471708 DDD:12530;chr3:195451991-195452447 dbVar;chr3:195457141-195468593 dbVar;3:195457249-195471074 dgv906e199;3:195457318-195471062 1000g 1158545;703362;668577;1066092;690004;794136;666582;674311;665255;915282;1019080;650094;650802;676953;689440;662061;669297;838978 gain;loss 0.470 0.415 3:195418975-195419071 MER3 3:195413607-195420395 3:195341901-195476900 High Signal Region 3:195341901-195476900 High Signal Region 95.22 6 4.7211e-03 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (3 genes, +0.00);5F (+0.00) 1 +3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA split q29 MIR570HG NR_122105 1 195415368 195438746 19578 0 0 no 5 intron2-txEnd UTR 2859 5' 195419168 195438746 1000g;DDD:12519;DDD:12528;DDD:12530;TS40:ISCA-46592;dbVar;dgv967e214;esv2760775;esv2763776 3:195240825-195502119;chr3:195272344-195742942;3:195320057-195470538;chr3:195340839-195456934;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;chr3:195398446-195473245;3:195417631-195471708;chr3:195417835-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776 0.4682 DDD:12519;DDD:12528;DDD:12530;HI40:ISCA-46589;dgv5017n100;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195380279-195469564;3:195383131-195446910;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708 0.0746 IMH 3:195371562-197367616;3:195376259-197363816;3:195409822-195693354;3:195413625-195689159;3:195417390-195684632;3:195418302-195683569 0.1142 440993 full=1 +3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA split q29 MIR570 NR_030296 1 195426271 195426368 97 0 0 no 1 txStart-txEnd UTR 195426271 195426368 1000g;DDD:12519;DDD:12528;DDD:12530;TS40:ISCA-46592;dbVar;dgv967e214;esv2760775;esv2763776 3:195240825-195502119;chr3:195272344-195742942;3:195320057-195470538;chr3:195340839-195456934;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;chr3:195398446-195473245;3:195417631-195471708;chr3:195417835-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776;3:195417836-195445776 0.4682 DDD:12519;DDD:12528;DDD:12530;HI40:ISCA-46589;dgv5017n100;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195380279-195469564;3:195383131-195446910;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708 0.0746 IMH 3:195371562-197367616;3:195376259-197363816;3:195409822-195693354;3:195413625-195689159;3:195417390-195684632;3:195418302-195683569 0.1142 693155 full=1 +3_195419169_195472855_DEL_1 3 195419169 195472855 -53686 DEL Benign NA split q29 MUC20 NM_001282506 2 195447848 195460422 12574 2130 100 no 4 txStart-txEnd 5'UTR-3'UTR 195447848 195460422 DDD:12519;DDD:12528;DDD:12530;TS40:ISCA-46592;dbVar;esv2760775;esv2763776 3:195240825-195502119;chr3:195272344-195742942;3:195320057-195470538;3:195376589-195493533;3:195383143-195502119;3:195385823-195474165;chr3:195398446-195473245;3:195417631-195471708 0.0556 DDD:12519;DDD:12528;DDD:12530;HI40:ISCA-46589;esv2760775;esv2763776 3:195240825-195502119;3:195320057-195470538;3:195380279-195469564;3:195383143-195502119;3:195385823-195474165;3:195417631-195471708 0.0746 IMH 3:195371562-197367616;3:195376259-197363816;3:195409822-195693354;3:195413625-195689159;3:195417390-195684632;3:195418302-195683569 0.1142 95.22 200958 6 4.7211e-03 full=1 +4_69392546_69462438_DEL_1 4 69392546 69462438 -69892 DEL Benign NA full q13.2 UGT2B17 TMPRSS11E UGT2B15 1 dbVar:nssv15165478;dbVar:nssv15148693;dbVar:nssv15165480;dbVar:nssv15164282;dbVar:nssv15149870;nssv15151360;dbVar:nssv15145710;dbVar:nssv17956560;dbVar:nssv15153593;dbVar:nssv15774461 4:11526-191028879;4:12441-190904441;4:49451-190915650;4:49451-190963766;4:68347-190957473;4:52697789-98426769;4:52866945-143582507;4:64705502-73469716;4:68242785-82991431 0.04;0.04;0.04;0.04;0.04;0.15;0.08;0.80;0.47 dbVar:nssv17173265;dbVar:nssv15165214;dbVar:nssv15125766;dbVar:nssv17969950;dbVar:nssv15141158;dbVar:nssv15132956;dbVar:nssv15132546;dbVar:nssv15137205;dbVar:nssv18830797;dbVar:nssv16207960 4:52757981-76930872;4:58332295-71587615;4:59167246-101910659;4:61867556-74711517;4:66017576-76772947;4:66320281-73179410;4:67708127-71697274;4:68665384-75106637;4:68698774-83637218;4:68950364-79738598 0.29;0.53;0.16;0.54;0.65;1.02;1.75;1.09;0.47;0.65 DDD:13999;dbVar;dgv1490e212;dgv5262n100;dgv5264n100 4:69360477-69485827;4:69364694-69524016;chr4:69365480-69553855;4:69371992-69489323;4:69371992-69540013;chr4:69373950-69490950 0.4178 1000g;DDD:13999;DDD:14001;DDD:14006;IMH;dbVar;dgv5262n100;dgv951e199;esv2421501;esv3600874;esv3893940;gnomAD-SV_v2.1_DEL_4_46338;nsv514223 4:69364694-69524016;4:69367085-69542363;4:69371992-69489323;4:69372046-69491392;4:69373660-69491275;chr4:69373811-69491113;4:69373811-69491113;4:69374942-69503681;chr4:69375591-69491543;4:69375592-69491543;4:69375592-69491543;4:69380302-69491200;4:69382081-69512905;4:69386966-69483317 0.8518 IMH 4:21758876-84442542;4:32219469-79170284 0.1946 4:69364694-69524016 DDD:13999;4:69366026-69430178 DDD:14000;4:69371992-69540013 dgv5264n100;4:69435890-69485966 dgv1493e212; 4:69360477-69485827 dgv1490e212;chr4:69365480-69553855 dbVar;4:69371992-69489323 dgv5262n100;chr4:69373950-69490950 dbVar;4:69435890-69551731 dgv1495e212 4:69364694-69524016 DDD:13999;4:69367085-69542363 DDD:14001;4:69372046-69491392 dgv951e199;chr4:69373747-69423167 dbVar;4:69373748-69423167 esv3600873;4:69373811-69491113 gnomAD-SV_v2.1_DEL_4_46338;4:69374942-69503681 esv2421501;4:69375592-69491543 1000g;4:69380302-69491200 DDD:14006;4:69386966-69483317 nsv514223;4:69426440-69454553 1000g;4:69435890-69485966 dgv1494e212;chr4:69441908-69442050 dbVar; 4:69360489-69396466 DDD:13998;4:69366026-69430178 DDD:14000;4:69371992-69489323 dgv5262n100;4:69373660-69491275 IMH;4:69373748-69423167 1000g;chr4:69373811-69491113 dbVar;4:69374942-69396466 DDD:14004;chr4:69375591-69491543 dbVar;4:69375592-69491543 esv3600874;4:69382081-69512905 esv3893940;chr4:69426439-69454553 dbVar;4:69426440-69454553 esv3600875;4:69435890-69558258 dgv1496e212;chr4:69446429-69446529 dbVar 1066120;2666915;1397960;1223404;1447809;2109610;2228872;2484300;2954216;2279170;2285811 loss;gain 0.400 0.365 4:69392108-69392544 Tigger2a 4:69462528-69462751 THE1B 4:69370649-69435791 87.45 0.741987855668132 1.6951286981971 601903 yes 5 9.6905e-08 1.0256e-02 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +4_69392546_69462438_DEL_1 4 69392546 69462438 -69892 DEL Benign NA split q13.2 UGT2B17 NM_001077 4 69402890 69442040 39150 1593 100 no 7 txStart-txEnd 5'UTR-3'UTR 69402890 69442040 DDD:13999;dbVar;dgv1490e212;dgv5262n100;dgv5264n100 4:69360477-69485827;4:69364694-69524016;chr4:69365480-69553855;4:69371992-69489323;4:69371992-69540013;chr4:69373950-69490950 0.4178 1000g;DDD:13999;DDD:14001;DDD:14006;IMH;dbVar;dgv5262n100;dgv951e199;esv2421501;esv3600874;esv3893940;gnomAD-SV_v2.1_DEL_4_46338;nsv514223 4:69364694-69524016;4:69367085-69542363;4:69371992-69489323;4:69372046-69491392;4:69373660-69491275;chr4:69373811-69491113;4:69373811-69491113;4:69374942-69503681;chr4:69375591-69491543;4:69375592-69491543;4:69375592-69491543;4:69380302-69491200;4:69382081-69512905;4:69386966-69483317 0.8518 IMH 4:21758876-84442542;4:32219469-79170284 0.1946 1397960 gain 87.45 0.741987855668132 1.6951286981971 7367 601903 (Bone mineral density QTL 12, osteoporosis), 612560 (3) yes 5 9.6905e-08 1.0256e-02 full=1 +6_266080_362290_DEL_1 6 266080 362290 -96210 DEL Benign NA full p25.3 DUSP22 LOC285766 IRF4 1 EXOC2 (morbid/RE=ABC_enhancer+EA_enhancer+GH_promoter_enhancer);FOXC1 (HI=3/morbid/RE=ABC_enhancer) dbVar:nssv15166690;dbVar:nssv15132417;dbVar:nssv15166692;dbVar:nssv15120571;dbVar:nssv17649861;dbVar:nssv15138806;dbVar:nssv15150238;dbVar:nssv15136852;dbVar:nssv15137715;dbVar:nssv15139508;dbVar:nssv15139953;dbVar:nssv15154408;dbVar:nssv15154409;dbVar:nssv15772668;dbVar:nssv15161578;dbVar:nssv15161859;nssv15161868;dbVar:nssv15132517;dbVar:nssv15133942;dbVar:nssv15135449;dbVar:nssv15131978;dbVar:nssv15168255;dbVar:nssv15124407;nssv15153178;dbVar:nssv15124483;dbVar:nssv16255328 6:60108-171054786;6:106432-18360826;6:108667-170980171;6:144958-5239414;6:149620-3951208;6:152635-14417234;6:152635-15732394;6:152635-6027780;6:155808-17058645;6:156975-11551050;6:156975-13081433;6:156975-13502033;6:156975-21955964;6:156975-23221621;6:156975-46757028;6:156976-170919482;6:163084-1951585;6:163084-2029765;6:163084-9525729;6:164361-13340113;6:165633-170919470;6:168776-24023234;6:255351-3189972;6:302184-3290583 0.06;0.53;0.06;1.89;2.53;0.67;0.62;1.64;0.57;0.84;0.74;0.72;0.44;0.42;0.21;0.06;5.38;5.15;1.03;0.73;0.06;0.40;3.28;2.01 dbVar:nssv15127418;dbVar:nssv15133557;dbVar:nssv15168254;dbVar:nssv15134981;dbVar:nssv15135893;dbVar:nssv15139184;dbVar:nssv16254736;dbVar:nssv15139679;dbVar:nssv15151182;dbVar:nssv16208808;dbVar:nssv15152915;dbVar:nssv15137052;dbVar:nssv15142299;dbVar:nssv15138353;dbVar:nssv18330309;dbVar:nssv15133558;dbVar:nssv15134713;dbVar:nssv15132439;dbVar:nssv15132039;dbVar:nssv15133559;dbVar:nssv15132182;dbVar:nssv15132440;dbVar:nssv15137716;dbVar:nssv15125242;dbVar:nssv15141126;dbVar:nssv15124398;dbVar:nssv15124411 6:60524-1768235;6:107683-4979015;6:108667-1505511;6:152635-5315912;6:152635-6027780;6:152635-6290037;6:152850-1888703;6:156975-13856156;6:156975-2030623;6:156975-2208360;6:156975-3398920;6:156975-4907926;6:156975-6417749;6:156975-7122992;6:156976-3718881;6:163084-2724845;6:163084-3459841;6:163084-5875635;6:163084-6063033;6:164634-5823834;6:164634-6284470;6:165676-9036267;6:170427-1622218;6:180960-2180143;6:195230-2117379;6:204010-11608587;6:204010-6447311 5.63;1.98;6.89;1.86;1.64;1.57;5.54;0.70;5.13;4.69;2.97;2.03;1.54;1.38;2.70;3.76;2.92;1.68;1.63;1.70;1.57;1.08;6.63;4.81;5.01;0.84;1.54 DDD:19553;DDD:19555;dbVar;dgv140e203;nsv514340 6:230528-373346;6:236002-373603;chr6:256313-383004;6:257333-380527;6:257354-382897 0.6839 DDD:19555;dbVar;dgv1701e212 chr6:180946-734275;6:236002-373603;6:254255-385771 0.1870 6:236002-373603 DDD:19555;6:253364-302293 dgv1695e212;chr6:256313-383004 dbVar;6:256503-293373 1000g;6:257333-380527 nsv514340;6:257354-294837 esv2421434;6:259529-339802 TS40:ISCA-37471;chr6:296702-383004 dbVar;chr6:305181-340601 dbVar;6:305182-340601 1000g;chr6:327586-368712 dbVar;6:327587-368712 1000g;6:344136-379149 DDD:19570 6:230528-373346 DDD:19553;6:253364-294911 dgv1694e212;chr6:256313-296702 dbVar;chr6:256502-293373 dbVar;6:256503-293373 dgv1157e214;6:257354-293393 DDD:19561;6:257354-382897 dgv140e203;6:294125-385771 dgv1705e212;6:298701-379015 esv2421645;6:305182-340601 1000g;6:305182-340601 dgv1158e214;6:327587-368712 1000g;6:327587-368712 dgv1159e214 6:236002-373603 DDD:19555;6:254255-385771 dgv1701e212;chr6:295586-296060 dbVar;chr6:295710-295782 dbVar;chr6:314312-314882 dbVar;chr6:340942-340994 dbVar; chr6:180946-734275 dbVar;6:252694-302294 dgv1693e212;6:259529-339802 HI40:ISCA-37471;6:295586-296060 gnomAD-SV_v2.1_DEL_6_65910;chr6:299088-299161 dbVar;chr6:329960-330054 dbVar;chr6:340943-340994 dbVar 857006;857659;609630;1938466;994363;887275;902698;2603845;857660;744870;744873;1429292;1807702;1591974;744881;746818;747174;1068500;1072273;1905160 gain;loss 0.365 0.315 6:266156-266836 L1MC3 6:362320-362381 MIRc 6:256601-382800 High Signal Region 6:256601-382800 High Signal Region 38.68 -1.35330421932959 -0.982727799381157 5 9.3421e-03 4.3071e-03 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +6_266080_362290_DEL_1 6 266080 362290 -96210 DEL Benign NA split p25.3 DUSP22 NM_001286555 3 292486 351355 58869 618 100 no 7 txStart-txEnd 5'UTR-3'UTR 292486 351355 DDD:19553;DDD:19555;dbVar;dgv140e203;nsv514340 6:230528-373346;6:236002-373603;chr6:256313-383004;6:257333-380527;6:257354-382897 0.6839 DDD:19555;dbVar;dgv1701e212 chr6:180946-734275;6:236002-373603;6:254255-385771 0.1870 1938466;994363;887275;902698;857660;744870;744873;1429292;1591974;744881;746818;747174;1068500;1072273 loss;gain 38.68 -1.35330421932959 -0.982727799381157 56940 5 9.3421e-03 4.3071e-03 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA full p23.1 FAM66B;DEFB109B;USP17L1;USP17L4;ZNF705G;DEFB4B;DEFB103B;SPAG11B;DEFB104B;DEFB106B;DEFB105B;DEFB107B;PRR23D1;FAM90A7;FAM90A22;FAM90A23;FAM90A14;FAM90A18;FAM90A16;FAM90A8;FAM90A17;FAM90A19;FAM90A9;FAM90A10;PRR23D2;DEFB107A;DEFB105A;DEFB106A;DEFB104A;SPAG11A;DEFB103A;DEFB4A LINC00965 ZNF705B 32 MCPH1 (morbid/RE=ABC_enhancer+GH_promoter_enhancer) dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161508;dbVar:nssv15161747;dbVar:nssv17976867;dbVar:nssv17957391;dbVar:nssv15154583;dbVar:nssv15161801;nssv15777239;nssv17976962;dbVar:nssv15154584;dbVar:nssv16206921;dbVar:nssv15154580;dbVar:nssv15161417;nssv15161657;dbVar:nssv15147671;dbVar:nssv15161846;dbVar:nssv15150473;dbVar:nssv15127651;dbVar:nssv15149098;dbVar:nssv15169210;dbVar:nssv15154582;dbVar:nssv15146537;dbVar:nssv15161807;dbVar:nssv15161553;dbVar:nssv15161105;dbVar:nssv15161095;dbVar:nssv15161561;dbVar:nssv15161078;dbVar:nssv15147455;dbVar:nssv16736635;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161749;dbVar:nssv15143576;dbVar:nssv15161775;dbVar:nssv15146180;dbVar:nssv15161087;dbVar:nssv15161068;dbVar:nssv15161792;dbVar:nssv15606063;dbVar:nssv15151542;dbVar:nssv15161084;dbVar:nssv16206931;dbVar:nssv15154577;dbVar:nssv15161089;dbVar:nssv15151538;dbVar:nssv15152254;dbVar:nssv18842054;dbVar:nssv15161540;dbVar:nssv15161727;dbVar:nssv15161764 8:10214-146293414;8:13939-146304022;8:46311-11879315;8:46311-30472220;8:158049-10348413;8:158049-11936107;8:158049-13974319;8:158049-146295771;8:158049-15423270;8:158049-8102819;8:158049-9750676;8:158050-146295771;8:158992-13304906;8:158992-146280828;8:158992-17536147;8:163683-46938942;8:164985-11860845;8:164985-146293414;8:168484-13147575;8:169854-10022996;8:176453-12556063;8:176453-12570496;8:176453-146294098;8:176453-16137655;8:176453-34349408;8:176453-37879246;8:176453-7838959;8:176815-43396776;8:191531-146274835;8:191531-146280020;8:191531-17536206;8:191531-22404983;8:191531-23055911;8:191531-7752586;8:191606-146280167;8:191606-24514484;8:191606-30948590;8:194618-13947374;8:1825201-24533193;8:6961184-12157391;8:6999220-11895232;8:6999220-11898980;8:6999220-38553064;8:6999220-8881836;8:7053187-11805960;8:7080282-12045269;8:7169491-12404062;8:7268820-12039974;8:7691902-12039974 0.40;0.40;4.94;1.92;5.73;4.96;4.23;0.40;3.83;7.35;6.09;0.40;4.44;0.40;3.36;1.25;4.99;0.40;4.50;5.93;4.72;4.71;0.40;3.66;1.71;1.55;7.62;1.35;0.40;0.40;3.37;2.63;2.55;7.71;0.40;2.40;1.90;4.25;2.57;11.24;11.93;11.92;1.85;31.03;12.29;11.76;11.16;10.16;1.42 dbVar:nssv15168702;dbVar:nssv15169206;dbVar:nssv18842057;dbVar:nssv17956019;dbVar:nssv15154581;dbVar:nssv18326425;dbVar:nssv15149861;dbVar:nssv15775686;dbVar:nssv17976739;dbVar:nssv16208166;dbVar:nssv15774257;dbVar:nssv15149509;dbVar:nssv18330306;dbVar:nssv18329623;dbVar:nssv16216869;dbVar:nssv15169209;dbVar:nssv15223191;dbVar:nssv15147275;dbVar:nssv15148964;dbVar:nssv15147296;dbVar:nssv15146181;nssv15146816;dbVar:nssv15606064;dbVar:nssv15146660;dbVar:nssv18841910;dbVar:nssv15161264;nssv15161582;dbVar:nssv15145917;dbVar:nssv15161283;dbVar:nssv15161284;dbVar:nssv15161070;dbVar:nssv15141976;dbVar:nssv15161050 8:10214-10197718;8:10214-8948469;8:10502-11142629;8:10502-7214947;8:158049-10939681;8:158049-11281408;8:158049-13309069;8:158049-14214722;8:158049-30187456;8:158049-9025197;8:158049-9393052;8:158049-9749574;8:158050-10965627;8:158050-18936715;8:161517-11516619;8:164985-10007227;8:176815-7753583;8:191531-10049105;8:191531-10315994;8:191531-10724642;8:191531-7752586;8:194618-7787444;8:360370-7334625;8:399894-23712417;8:2292236-27361796;8:3791728-11384448;8:7053187-12241152;8:7092360-12372324;8:7169491-12404062;8:7268820-11805960;8:7268820-11819316 5.73;6.53;5.25;0.63;5.42;5.25;4.44;4.16;1.95;6.59;6.32;6.09;5.40;3.11;5.14;5.93;7.71;5.93;5.77;5.55;7.71;7.69;2.37;2.51;2.33;7.69;11.26;11.06;11.16;10.68;10.65 DDD:26674;TS40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 8:6858816-8072303 esv2761169;8:6985776-7230992 DDD:26670;8:7035907-7428513 DDD:26675;8:7154889-7213289 DDD:26682;chr8:7159226-7201223 dbVar;8:7170611-7177489 nsv515099;chr8:7190000-7195000 dbVar;8:7201176-7392220 DDD:26689;chr8:7212582-7227421 dbVar;8:7212583-7227421 1000g;8:7212583-7227421 TS40:ISCA-46631;8:7241528-7403182 nsv515100;8:7250369-7832042 dgv6936n100;8:7283000-7289250 gnomAD-SV_v2.1_DUP_8_23698;8:7335400-7408600 gnomAD-SV_v2.1_DUP_8_23699;chr8:7365000-7404400 dbVar;8:7393000-7403950 gnomAD-SV_v2.1_DUP_8_23701;chr8:7403133-7474073 dbVar;chr8:7424800-7474000 dbVar;chr8:7525167-7866528 dbVar;chr8:7532000-7545000 dbVar... chr8:6828277-7474073 dbVar;8:6959834-8600711 esv2764098;8:7024892-8031414 DDD:26674;8:7053187-8130689 TS40:ISCA-37472;chr8:7159226-7187516 dbVar;chr8:7159226-7474073 dbVar;chr8:7187516-7201223 dbVar;8:7190891-7190961 DDD:26685;chr8:7206400-7253000 dbVar;8:7212583-7227421 1000g;8:7212583-7227421 1000g;8:7212583-7227421 dgv1365e214;chr8:7243000-7356000 dbVar;8:7273500-7474150 gnomAD-SV_v2.1_DUP_8_23697;8:7308244-7308706 DDD:26704;chr8:7355000-7365050 dbVar;8:7374000-7380000 gnomAD-SV_v2.1_DUP_8_23700;8:7401394-7472190 DDD:26720;chr8:7404000-7437650 dbVar;chr8:7525167-7633135 dbVar;chr8:7525167-8097772 dbVar... 8:6959834-8600711 esv2764098;8:7024892-8031414 DDD:26674;8:7053187-8130689 HI40:ISCA-37472;8:7154889-7213289 DDD:26682;8:7158202-7189800 DDD:26683;chr8:7179582-7191032 dbVar;8:7179583-7191032 esv3616115;8:7190891-7190961 DDD:26685;chr8:7201000-7206400 dbVar;chr8:7204184-7204308 dbVar;8:7212583-7227421 1000g;chr8:7221359-7221602 dbVar;8:7228000-7235000 gnomAD-SV_v2.1_DEL_8_89335;chr8:7286205-7286328 dbVar;chr8:7326402-7326559 dbVar;8:7355000-7363000 gnomAD-SV_v2.1_DEL_8_89340;8:7355294-7364762 1000g;8:7401394-7472190 DDD:26720;8:7402900-7419700 gnomAD-SV_v2.1_DEL_8_89341;8:7405950-7443050 gnomAD-SV_v2.1_DEL_8_89342;8:7417000-7425000 gnomAD-SV_v2.1_DEL_8_89343... 8:6858816-8072303 esv2761169;8:6985776-7230992 DDD:26670;8:7035907-7428513 DDD:26675;chr8:7085462-7537934 dbVar;8:7158046-7189992 esv2675221;chr8:7175745-7175870 dbVar;8:7179583-7191032 1000g;chr8:7180382-7180743 dbVar;8:7190892-7196288 DDD:26687;8:7201000-7206400 gnomAD-SV_v2.1_DEL_8_89332;chr8:7212582-7227421 dbVar;8:7212583-7227421 esv3616116;chr8:7228000-7235000 dbVar;chr8:7276552-7277128 dbVar;8:7308244-7308706 DDD:26704;chr8:7355000-7363000 dbVar;chr8:7355293-7364762 dbVar;8:7355294-7364762 esv3616120;chr8:7402900-7419700 dbVar;chr8:7405950-7443050 dbVar;chr8:7417000-7425000 dbVar... 674618;1021421;1021422;646653;1520679;1915732;3052323;2599287;832406;665154;653853;679166;678976;663306;700319;654990;679312;646920;863772;653647;649616;671308;658988;675704;1023557;678564;857770;745967;654991;676140;783310;824013;870858;820152;834536;871873;875246;654992;701040;665155;745968;682446;745969;702113;890458;732002;921361;909011;880183;1018294;925302;... loss;gain 0.260 0.330 8:7150797-7184572;8:7150797-7195814;8:7150797-7200543;8:7150798-7238459 8:7600001-7825413 8:7012601-8066200 High Signal Region 8:7012601-8066200 High Signal Region 99.72 2.14121257165536 2.19863945242443 8 4.2180e-01 5.1947e-01 -1.0 1A (cf Gene_count, RE_gene, +0.00);2D (cf B_gain_source, -1.00);2B (cf po_P_gain_source, TS, OMIM_morbid+0.00);2E (cf B_gain_source, +0.00);2L (DEFB4A/FAM66B, +0.00);3A (32 genes, +0.00);5F (+0.00) 1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM66B NR_027423 2 7156265 7212885 43395 0 0 no 7 txStart-intron6 UTR 9797 3' 7169490 7212885 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7474073 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289 0.2237 100128890 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB109B NM_001037380 2 7170243 7177618 7375 264 100 no 2 txStart-txEnd 5'UTR-3'UTR 7170243 7177618 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7187516;chr8:7159226-7201223;chr8:7159226-7474073 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26683;HI40:ISCA-37472;dbVar;esv2675221;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289;8:7158046-7189992;8:7158202-7189800 0.2237 641517 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 USP17L1 NM_001256873 1 7189908 7191501 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7189908 7191501 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7201223;chr8:7159226-7474073;chr8:7187516-7201223 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289 0.2237 401447 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 USP17L4 NM_001256874 1 7194636 7196229 1593 1593 100 no 1 txStart-txEnd 5'UTR-3'UTR 7194636 7196229 DDD:26670;DDD:26674;DDD:26675;DDD:26682;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;8:7154889-7213289;chr8:7159226-7201223;chr8:7159226-7474073;chr8:7187516-7201223 0.2355 DDD:26670;DDD:26674;DDD:26675;DDD:26682;DDD:26687;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:6985776-7230992;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7154889-7213289;8:7190892-7196288 0.2237 645402 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 ZNF705G NM_001164457 3 7213038 7243080 30042 903 100 no 7 txStart-txEnd 5'UTR-3'UTR 7213038 7243080 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;esv2761169;esv2764098 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;chr8:7206400-7253000 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 1023557;745967;654991;676140;745968;732002 loss;gain 91.1 -1.59751875296103 -3.97736276921453 100131980 9 1.6471e-08 4.2486e-09 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB4B NM_001205266 2 7272376 7274385 2009 195 100 no 2 txStart-txEnd 5'UTR-3'UTR 7272376 7274385 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 99.72 100289462 9 6.7977e-02 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB103B NM_018661 4 7286409 7287870 1461 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7286409 7287870 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23698;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150;8:7283000-7289250 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 85.97 55894 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 SPAG11B NM_058201 4 7308124 7321064 12940 402 100 no 3 txStart-txEnd 5'UTR-3'UTR 7308124 7321064 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 89.4 2.14121257165536 1.8677219993927 10407 9 2.7751e-02 4.7238e-02 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB104B NM_001040702 1 7327829 7332604 4775 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7327829 7332604 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 95.66 503618 9 3.3176e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB106B NM_001040704 2 7340025 7343922 3897 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7340025 7343922 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 93.29 503841 9 8.1151e-02 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB105B NM_001040703 3 7345200 7347115 1915 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7345200 7347115 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;chr8:7243000-7356000;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 90.95 504180 9 2.9184e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB107B NM_001040705 2 7353432 7366833 13401 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7353432 7366833 DDD:26674;DDD:26675;DDD:26689;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7201176-7392220;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600 0.2355 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 603719;849088;921364 gain 91.71 503614 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 PRR23D1 NM_001282479 1 7397148 7399972 2824 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7397148 7399972 DDD:26674;DDD:26675;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697;gnomAD-SV_v2.1_DUP_8_23699;gnomAD-SV_v2.1_DUP_8_23701;nsv515100 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7241528-7403182;8:7250369-7832042;8:7273500-7474150;8:7335400-7408600;chr8:7365000-7404400;8:7393000-7403950 0.5625 DDD:26674;DDD:26675;HI40:ISCA-37472;dbVar;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934 0.2237 100131608 8 4.2180e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A7 NM_001397387 1 7414221 7417234 3013 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7414221 7417234 DDD:26674;DDD:26675;DDD:26720;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7159226-7474073;8:7250369-7832042;8:7273500-7474150;8:7401394-7472190;chr8:7403133-7474073;chr8:7404000-7437650 0.2355 DDD:26674;DDD:26675;DDD:26720;HI40:ISCA-37472;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89341;gnomAD-SV_v2.1_DEL_8_89342 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7035907-7428513;8:7053187-8130689;chr8:7085462-7537934;8:7401394-7472190;chr8:7402900-7419700;8:7402900-7419700;chr8:7405950-7443050;8:7405950-7443050 0.5803 441317 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A22 NM_001397382 1 7429516 7432528 3012 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7429516 7432528 DDD:26674;DDD:26720;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7159226-7474073;8:7250369-7832042;8:7273500-7474150;8:7401394-7472190;chr8:7403133-7474073;chr8:7404000-7437650;chr8:7424800-7474000 0.2355 DDD:26674;DDD:26720;HI40:ISCA-37472;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89342 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7085462-7537934;8:7401394-7472190;chr8:7405950-7443050;8:7405950-7443050 0.4842 645558 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A23 NM_001397380 1 7437165 7440175 3010 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7437165 7440175 DDD:26674;DDD:26720;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23697 chr8:6828277-7474073;8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7159226-7474073;8:7250369-7832042;8:7273500-7474150;8:7401394-7472190;chr8:7403133-7474073;chr8:7424800-7474000 0.2355 DDD:26674;DDD:26720;HI40:ISCA-37472;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89342 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;chr8:7085462-7537934;8:7401394-7472190;chr8:7405950-7443050;8:7405950-7443050 0.4842 645572 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A14 NM_001164452 1 7572964 7575975 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7572964 7575975 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23703 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;8:7570000-7579000 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 645651 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A18 NM_001164451 1 7580612 7583623 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7580612 7583623 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441326 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A16 NM_001397396 1 7588260 7591271 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7588260 7591271 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441323 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A8 NM_001164450 1 7595908 7598918 3010 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7595908 7598918 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441324 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A17 NM_001397391 1 7603555 7606566 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7603555 7606566 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 728746 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A19 NM_001164449 1 7611203 7614214 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7611203 7614214 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700;chr8:7608000-7649500 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 728753 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A9 NM_001164448 1 7618851 7621862 3011 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7618851 7621862 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7573000-7626700;chr8:7608000-7649500 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441327 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 FAM90A10 NM_001164447 1 7626498 7629510 3012 1395 100 no 4 txStart-txEnd 5'UTR-3'UTR 7626498 7629510 DDD:26674;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7633135;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7608000-7649500 0.2355 DDD:26674;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689 0.2237 441328 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 PRR23D2 NM_001282478 1 7636112 7638935 2823 840 100 no 4 txStart-txEnd 5'UTR-3'UTR 7636112 7638935 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;chr8:7608000-7649500;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 100133251 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB107A NM_001037668 1 7669241 7673238 3997 213 100 no 2 txStart-txEnd 5'UTR-3'UTR 7669241 7673238 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 682133 gain 92.48 245910 9 3.2633e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB105A NM_152250 3 7678525 7681402 2877 237 100 no 3 txStart-txEnd 5'UTR-3'UTR 7678525 7681402 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23704;gnomAD-SV_v2.1_DUP_8_23705 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7671000-7682600;8:7671000-7687000 0.2648 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 90.61 0.918523398770926 0.00809335391872301 245908 8 3.7719e-01 4.3625e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB106A NM_152251 4 7682660 7686575 3915 198 100 no 2 txStart-txEnd 5'UTR-3'UTR 7682660 7686575 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23705 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7671000-7687000 0.2648 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 90.45 0.676417083229402 1.6332400949348 245909 9 8.5821e-03 4.0931e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB104A NM_080389 3 7693957 7698764 4807 219 100 no 2 txStart-txEnd 5'UTR-3'UTR 7693957 7698764 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 96.98 1.33624136747443 2.19863945242443 140596 9 9.3748e-02 5.1947e-01 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 SPAG11A NM_001395484 1 7705529 7718465 12936 402 100 no 3 txStart-txEnd 5'UTR-3'UTR 7705529 7718465 DDD:26674;DDD:26727;DDD:26729;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630 0.2237 97.15 0.140072348156658 0.903069021299127 653423 9 6.9645e-05 3.9012e-02 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB103A NM_001081551 4 7738913 7740185 1272 204 100 no 2 txStart-txEnd 5'UTR-3'UTR 7738913 7740185 DDD:26674;DDD:26727;DDD:26729;DDD:26742;DDD:26743;TS40:ISCA-37472;TS40:ISCA-46381;dbVar;dgv6936n100;esv2761169;esv2764098;gnomAD-SV_v2.1_DUP_8_23708 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7718891-7784263;8:7734213-7856702;8:7737000-7743100;chr8:7737000-7743100;8:7737000-7743100 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;HI40:ISCA-46380;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89353 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630;8:7736500-7764500;chr8:7736500-7764500;8:7736500-7764500 0.3262 93.4 414325 full=1 +8_7169491_7753583_DUP_1 8 7169491 7753583 584092 DUP Benign NA split p23.1 DEFB4A NM_004942 4 7752198 7754238 1385 58 29 yes 2 txStart-intron1 5'UTR-CDS 412 3' 7752198 7753583 DDD:26674;DDD:26727;DDD:26729;DDD:26742;DDD:26743;TS40:ISCA-37472;dbVar;dgv6936n100;esv2761169;esv2764098 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7250369-7832042;chr8:7525167-7866528;chr8:7525167-8097772;8:7632945-7856630;chr8:7633800-7810300;8:7634705-7829839;8:7718891-7784263;8:7734213-7856702 0.2355 DDD:26674;DDD:26727;HI40:ISCA-37472;HI40:ISCA-46380;HI40:ISCA-46382;dbVar;esv2761169;esv2764098;gnomAD-SV_v2.1_DEL_8_89353;gnomAD-SV_v2.1_DEL_8_89355 8:6858816-8072303;8:6959834-8600711;8:7024892-8031414;8:7053187-8130689;8:7632945-7856630;8:7736500-7764500;chr8:7736500-7764500;8:7736500-7764500;8:7745000-7754100;chr8:7745000-7754100;8:7745000-7754100 0.5182 97.87 1.12959151611996 0.758429673080804 1673 9 1.1637e-03 3.9981e-01 full=1 +8_141035364_141061798_DEL_1 8 141035364 141061798 -26434 DEL DI AR Pathogenic NA full q24.3 TRAPPC9 C8orf17 PEG13 1 KCNK9 (morbid/RE=ABC_enhancer+GH_enhancer) dbVar:nssv15169207;dbVar:nssv15128680;dbVar:nssv15161801;nssv15777239;nssv17976962;dbVar:nssv15161417;nssv15161657;dbVar:nssv15161846;dbVar:nssv15169210;dbVar:nssv15161105;dbVar:nssv15161269;dbVar:nssv15161748;dbVar:nssv15161087;dbVar:nssv15161426;dbVar:nssv15161357;dbVar:nssv15777249;dbVar:nssv18326351;dbVar:nssv17970300;dbVar:nssv15161337;dbVar:nssv15161103;dbVar:nssv17977109;dbVar:nssv15161374;dbVar:nssv15161674;dbVar:nssv15161669;dbVar:nssv15161791;dbVar:nssv15161680;dbVar:nssv15161065;dbVar:nssv17976072;dbVar:nssv15161091;dbVar:nssv15161853;dbVar:nssv15161352;dbVar:nssv15161104;dbVar:nssv15161722;dbVar:nssv15161428;dbVar:nssv16208199;dbVar:nssv15162410;dbVar:nssv15773510;dbVar:nssv15774288;dbVar:nssv15161330;dbVar:nssv15161750;dbVar:nssv16206976;dbVar:nssv15161266;dbVar:nssv17970325;dbVar:nssv15131822;dbVar:nssv18841906;dbVar:nssv15161331;dbVar:nssv15143620;dbVar:nssv15161849;dbVar:nssv15775349;dbVar:nssv15161867;dbVar:nssv15775091;dbVar:nssv15161075;dbVar:nssv15161551 8:10214-146293414;8:13939-146304022;8:158049-146295771;8:158050-146295771;8:158992-146280828;8:164985-146293414;8:176453-146294098;8:191531-146274835;8:191531-146280020;8:191606-146280167;8:12491000-146295771;8:21149034-146295771;8:31936552-146295771;8:68912433-146295771;8:70382991-146295771;8:78392287-146294098;8:79526313-146280020;8:84712254-146295771;8:86778229-146295771;8:86841155-146295771;8:86841229-142689874;8:88943381-146294098;8:93047483-141355635;8:95694383-146294042;8:96496504-146295711;8:98395102-146295771;8:98432251-146222672;8:101879572-146295771;8:104318565-146294098;8:114592632-146280020;8:114853127-146295771;8:121042468-146295771;8:121694650-146295771;8:122193547-146295771;8:125496224-146295771;8:125510740-146294098;8:125526332-146280020;8:128877996-146295771;8:129233159-146274835;8:130863094-146295771;8:131127765-142238309;8:131138344-143473913;8:131651429-146294098;8:131682564-146280020;8:134825278-146280828;8:136059860-146295771;8:136378790-146295771;8:139188798-146295771;8:140016462-146274835;8:140249068-146294098 0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.02;0.03;0.03;0.04;0.04;0.04;0.04;0.04;0.05;0.05;0.05;0.05;0.05;0.06;0.06;0.06;0.06;0.08;0.08;0.10;0.11;0.11;0.13;0.13;0.13;0.15;0.16;0.17;0.24;0.21;0.18;0.18;0.23;0.26;0.27;0.37;0.42;0.44 Intellectual developmental disorder, AR 13, 613192 (3) AR dbVar:nssv16208202;dbVar:nssv15127815;morbid:TRAPPC9 8:126892815-143750028;8:127638607-144388560;8:140739968-141468678 0.16;0.16;3.63 dbVar chr8:140980774-141135131 0.01 8:141048063-141048063 1000g chr8:141040435-141042904 dbVar chr8:140980774-141135131 dbVar 0.535 0.380 8:141035378-141035461;8:141035462-141035486 MER58C;(CAAAA)n 53.39 0.107633755409335 -1.97676981971355 -1.34878674017516 -0.190632175596259 1.58912949219012 611966 yes 3 2.2898e-14 5.7604e-06 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +8_141035364_141061798_DEL_1 8 141035364 141061798 -26434 DEL DI AR Pathogenic NA split q24.3 TRAPPC9 NM_001160372 4 140739967 141467843 26435 0 0 no 23 intron17-intron17 CDS 1187 3' 141035363 141061798 dbVar chr8:140980774-141135131 0.01 30 0 53.39 0.107633755409335 -1.97676981971355 -1.34878674017516 -0.190632175596259 1.58912949219012 autosomal recessive non-syndromic intellectual disability;intellectual disability, autosomal recessive 13;intellectual disability-obesity-brain malformations-facial dysmorphism syndrome AR Definitive;Moderate;Strong;Supportive 17120046;2000476;20004763;20004764;20004765;20004765[PMID]_20004763[PMID]_20004765[PMID];22549410;22549410[PMID] 83696 611966 Intellectual developmental disorder, AR 13, 613192 (3) AR AR yes 3 2.2898e-14 5.7604e-06 full=1 +14_107152093_107180095_DEL_1 14 107152093 107180095 -28002 DEL Benign NA full q32.33 LINC00221 MIR5195 0 dbVar:nssv15162475;dbVar:nssv15161908;dbVar:nssv15162476;dbVar:nssv15161629;dbVar:nssv15161107;nssv15161424;dbVar:nssv15161067;dbVar:nssv15161689;dbVar:nssv15161760;dbVar:nssv15161081;dbVar:nssv18330720;dbVar:nssv15161039;dbVar:nssv15161040;dbVar:nssv15777241;dbVar:nssv15125898;dbVar:nssv15161535;dbVar:nssv15777234;dbVar:nssv15161537;dbVar:nssv15606082;dbVar:nssv15161360;dbVar:nssv15135151 14:19000423-107289053;14:19280734-107287663;14:19327824-107287663;14:19794562-107234280;14:20511674-107285437;14:20619309-107263478;14:73750742-107285437;14:74122476-107287505;14:77689139-107287505;14:84537503-107285437;14:86560375-107240869;14:91922206-107240869;14:91969029-107285437;14:93331785-107289540;14:98104858-107263478;14:99794231-107285437;14:99914350-107258824;14:100575918-107281934;14:103788752-107263478;14:106252706-107263478 0.03;0.03;0.03;0.03;0.03;0.03;0.08;0.08;0.09;0.12;0.14;0.18;0.18;0.20;0.31;0.37;0.38;0.42;0.81;2.77 dbVar:nssv15161324;dbVar:nssv16215328;dbVar:nssv15161030;dbVar:nssv15161062;dbVar:nssv15142554;dbVar:nssv15161267;dbVar:nssv15161579;dbVar:nssv15161268;dbVar:nssv17968992;dbVar:nssv15161102;dbVar:nssv15161557;dbVar:nssv16255573;dbVar:nssv15142555;dbVar:nssv15161354;dbVar:nssv18841864;dbVar:nssv15777252;dbVar:nssv15161369;dbVar:nssv15141232;nssv16208943;dbVar:nssv18830964;dbVar:nssv15150359;dbVar:nssv15161271;dbVar:nssv15161574;dbVar:nssv15161803;dbVar:nssv16208399;dbVar:nssv15142293;dbVar:nssv16208400;dbVar:nssv15120383;dbVar:nssv15137946 14:95990745-107287708;14:96829291-107287663;14:98404975-107263478;14:100297993-107263478;14:100661320-107285437;14:100775720-107263478;14:101048397-107285437;14:101274638-107263478;14:101732159-107285437;14:102131940-107263478;14:102392008-107284531;14:102615954-107285437;14:102670707-107285437;14:102705760-107285437;14:102729778-107283138;14:102931120-107285437;14:103071434-107287505;14:103153638-107285437;14:103636648-107285437;14:103965060-107285437;14:104251096-107278770;14:104289938-107287505;14:104517596-107285437;14:104764079-107285437;14:104915609-107285437;14:105303585-107285437;14:105489734-107258965;14:106252706-107287505 0.25;0.27;0.32;0.40;0.42;0.43;0.45;0.47;0.50;0.55;0.57;0.60;0.61;0.61;0.61;0.64;0.66;0.68;0.77;0.84;0.92;0.93;1.01;1.11;1.18;1.41;1.58;2.71 DDD:43963;TS40:ISCA-37477;dbVar;esv2760346 14:106050001-107289540;14:106437088-107285437;14:107136632-107191499;chr14:107146792-107184013 0.0828 DDD:43904;DDD:43963;HI40:ISCA-37477;esv2760346 14:106050001-107289540;14:106437088-107285437;14:106700994-107266403;14:107136632-107191499 0.2438 14:106437088-107285437 esv2760346;14:107136632-107191499 DDD:43963;chr14:107138985-107167914 dbVar;14:107145552-107179808 dgv699e212;chr14:107146792-107155491 dbVar;14:107147167-107164532 TS40:ISCA-46684;chr14:107160195-107167914 dbVar;chr14:107169033-107171740 dbVar;chr14:107169033-107184013 dbVar;chr14:107170011-107184013 dbVar;chr14:107171740-107184013 dbVar;chr14:107171740-107186229 dbVar 14:106050001-107289540 TS40:ISCA-37477;14:106874357-107164992 IMH;chr14:107137417-107155491 dbVar;chr14:107138985-107170011 dbVar;chr14:107145774-107155491 dbVar;chr14:107146792-107184013 dbVar;14:107147167-107164532 dgv428e214;chr14:107160195-107169033 dbVar;chr14:107169033-107177012 dbVar;chr14:107170011-107171740 dbVar;chr14:107170011-107185374 dbVar;chr14:107171740-107185374 dbVar 14:106437088-107285437 esv2760346;14:107054315-107166266 DDD:43951;chr14:107138985-107155491 dbVar;14:107172849-107183396 HI40:ISCA-46673;14:107174372-107174933 IMH;14:107174399-107174927 DDD:43974; 14:106050001-107289540 HI40:ISCA-37477;14:106700994-107266403 DDD:43904;14:107136632-107191499 DDD:43963;chr14:107171543-107171645 dbVar;14:107172849-107183396 esv3635707;14:107174391-107174931 esv3635708;14:107174399-107174927 esv2665347 0.355 0.425 14:107151001-107176900 High Signal Region -1.6 1B (cf Gene_count, RE_gene, -0.60);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (0 gene, +0.00);5F (+0.00) 1 +6_78979173_79023328_DEL_1 6 78979173 79023328 -44155 DEL Benign NA full q14.1 MEI4 MIR10524 0 dbVar:nssv15166690;dbVar:nssv15166692;dbVar:nssv15161859;nssv15161868;dbVar:nssv15168255;dbVar:nssv15606075;dbVar:nssv17970109;dbVar:nssv15148895 6:60108-171054786;6:108667-170980171;6:156976-170919482;6:165633-170919470;6:29455466-81447367;6:69938253-94379210;6:75092524-142361637 0.03;0.03;0.03;0.03;0.08;0.18;0.07 dbVar:nssv17976865;dbVar:nssv15138420;dbVar:nssv17957115;dbVar:nssv17956905;dbVar:nssv15154430;dbVar:nssv16255333;dbVar:nssv15139907;dbVar:nssv16215036 6:64954688-79581678;6:65259549-84136510;6:70165297-79920769;6:72799055-83275894;6:73674613-84829774;6:74226560-80208037;6:76635917-93420511;6:78562076-79746800 0.30;0.23;0.45;0.42;0.40;0.74;0.26;3.73 DDD:21366;dbVar;dgv768n27;nsv516597 chr6:78847213-79050801;chr6:78847817-79479628;6:78848098-79052702;chr6:78892808-79053430;6:78950789-79066065;chr6:78967097-79036275;6:78973202-79031742 0.3704 1000g;DDD:21366;DDD:21369;DDD:21373;IMH;dbVar;dgv10802n54;dgv1137e199;dgv1810e212;dgv1811e212;dgv6030n100;dgv6037n100;dgv766n27;dgv767n27;dgv769n27;esv2422170;esv2760997;esv2763987;esv3609657;esv3609663;esv3890888;gnomAD-SV_v2.1_DEL_6_70839;nsv514376;nsv516597 6:78836835-79051952;6:78848098-79052702;chr6:78892808-79053430;6:78892809-79053430;6:78892809-79053430;6:78950789-79066065;6:78961945-79041809;6:78962294-79041760;6:78962541-79031742;6:78962541-79052702;6:78962582-79027502;6:78962582-79041797;chr6:78962843-79034588;6:78965526-79033478;chr6:78967097-79036275;6:78967098-79036275;6:78967098-79036275;6:78967173-79036477;chr6:78967187-79036419;6:78967187-79036419;6:78967195-79036475;6:78967195-79036497;6:78969054-79027758;6:78969066-79031970;6:78969066-79035185;6:78972098-79031153;6:78972931-79033478;6:78973202-79031742 0.4631 IMH 6:49889718-107723757 0.1414 chr6:78847817-79479628 dbVar;chr6:78892808-79053430 dbVar;6:78963972-78992918 DDD:21367;6:78973202-79031742 dgv768n27; chr6:78847213-79050801 dbVar;6:78848098-79052702 nsv516597;6:78950789-79066065 DDD:21366;chr6:78967097-79036275 dbVar;6:78999918-79033124 DDD:21375 6:78848098-79052702 nsv516597;6:78892809-79053430 1000g;6:78950789-79066065 DDD:21366;6:78962294-79041760 dgv1810e212;6:78962541-79052702 dgv767n27;6:78962582-79041797 dgv6030n100;6:78965526-79033478 esv3890888;6:78967098-79036275 1000g;6:78967173-79036477 IMH;6:78967187-79036419 gnomAD-SV_v2.1_DEL_6_70839;6:78967195-79036497 dgv1137e199;6:78969066-79031970 DDD:21373;6:78972098-79031153 nsv514376;6:78973202-79031742 dgv769n27 6:78836835-79051952 esv2760997;chr6:78892808-79053430 dbVar;6:78892809-79053430 esv3609657;6:78961945-79041809 esv2763987;6:78962541-79031742 dgv766n27;6:78962582-79027502 dgv1811e212;chr6:78962843-79034588 dbVar;chr6:78967097-79036275 dbVar;6:78967098-79036275 esv3609663;chr6:78967187-79036419 dbVar;6:78967195-79036475 DDD:21369;6:78969054-79027758 dgv6037n100;6:78969066-79035185 esv2422170;6:78972931-79033478 dgv10802n54 0.325 0.270 -1.6 1B (cf Gene_count, RE_gene, -0.60);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (0 gene, +0.00);5F (+0.00) 1 diff --git a/share/doc/AnnotSV/Images/AnnotSV_logo.png b/share/doc/AnnotSV/Images/AnnotSV_logo.png old mode 100755 new mode 100644 diff --git a/docs/images/AnnotSV_overview.jpg b/share/doc/AnnotSV/Images/AnnotSV_overview.jpg similarity index 100% rename from docs/images/AnnotSV_overview.jpg rename to share/doc/AnnotSV/Images/AnnotSV_overview.jpg diff --git a/docs/images/gpl.png b/share/doc/AnnotSV/Images/gpl.png similarity index 100% rename from docs/images/gpl.png rename to share/doc/AnnotSV/Images/gpl.png diff --git a/docs/annotations.md b/share/doc/AnnotSV/annotations.md similarity index 90% rename from docs/annotations.md rename to share/doc/AnnotSV/annotations.md index 5380bda..78461da 100644 --- a/docs/annotations.md +++ b/share/doc/AnnotSV/annotations.md @@ -2,6 +2,6 @@ AnnotSV requires different data sources for the annotation and the ranking of SV. In order to provide a ready to start installation of AnnotSV, each annotation source (that do not require a commercial license) is automatically downloaded during the installation. -The aim of each of these sources is fully explained in the [README](../README.AnnotSV_latest.pdf) file. +The aim of each of these sources is fully explained in the [README](../../../README.AnnotSV_3.4.pdf) file. -Annotation can be performed using either the GRCh37 or GRCh38 build of the human genome (user defined). Some of the annotations are linked to the gene name and thus provided independently of the genome build. \ No newline at end of file +Annotation can be performed using either the GRCh37 or GRCh38 build of the human genome (user defined). Some of the annotations are linked to the gene name and thus provided independently of the genome build. diff --git a/docs/quickstart.md b/share/doc/AnnotSV/quickstart.md similarity index 90% rename from docs/quickstart.md rename to share/doc/AnnotSV/quickstart.md index 78c9936..270f57e 100644 --- a/docs/quickstart.md +++ b/share/doc/AnnotSV/quickstart.md @@ -1,7 +1,7 @@ # Quick Installation -Requirements are fully explained in the [README](../README.AnnotSV_latest.pdf) file. +Requirements are fully explained in the [README](../../../README.AnnotSV_3.4.pdf) file. 1. The sources can be cloned to any directory: ``` diff --git a/docs/ranking.md b/share/doc/AnnotSV/ranking.md similarity index 87% rename from docs/ranking.md rename to share/doc/AnnotSV/ranking.md index e33d2e7..30822b2 100644 --- a/docs/ranking.md +++ b/share/doc/AnnotSV/ranking.md @@ -16,4 +16,4 @@ In order to assist the clinical interpretation of SV, AnnotSV provides on top of # Method -The comprehensive and detailed scoring guidelines are available in the [Scoring_Criteria_AnnotSV](../Scoring_Criteria_AnnotSV_latest.xlsx) file (see Table1 for loss SV and Table2 for gain SV). \ No newline at end of file +The comprehensive and detailed scoring guidelines are available in the [Scoring_Criteria_AnnotSV](../../../Scoring_Criteria_AnnotSV_v3.4.xlsx) file (see Table1 for loss SV and Table2 for gain SV). diff --git a/docs/webserver_overview.md b/share/doc/AnnotSV/webserver_overview.md similarity index 89% rename from docs/webserver_overview.md rename to share/doc/AnnotSV/webserver_overview.md index 15684b4..c9fdac6 100644 --- a/docs/webserver_overview.md +++ b/share/doc/AnnotSV/webserver_overview.md @@ -11,10 +11,10 @@ The user can add optional sample related information such as the HPO terms to he ## Annotations AnnotSV compiles functionally, regulatory and clinically **relevant information** and aims at providing annotations useful to i) **interpret SV potential pathogenicity and ii) filter out SV potential false positives.**
    -These **relevant annotations** are detailed in the [README](../README.AnnotSV_latest.pdf). +These **relevant annotations** are detailed in the [README](../../../README.AnnotSV_3.4.pdf). ## Phenotype-driven prioritization -To link the patient's phenotypic data to the already available knowledge for each gene, AnnotSV provide a phenotype driven prioritization module based on the [HPO (Human Phenotype Ontology) dataset](https://pubmed.ncbi.nlm.nih.gov/30476213/) and [Exomiser](https://www.nature.com/articles/nprot.2015.124) to score each SV (from 0 to 1.0). We generally recommend a score above 0.7 for a known disease gene and 0.5 for a gene not yet related to a disease. +To link the patient's phenotypic data to the already available knowledge for each gene, AnnotSV provide a phenotype driven prioritization module based on the [HPO (Human Phenotype Ontology) dataset](https://pubmed.ncbi.nlm.nih.gov/30476213/). ## Ranking In addition, AnnotSV provides on top of the annotations **a ranking score** to assess SV pathogenicity. @@ -40,4 +40,4 @@ Every SV are reported, even those not covering a gene. This type of annotation g - An annotation of the SV **“split” by gene**: This type of annotation gives an opportunity to focus on each gene overlapped by the SV. Thus, when a SV spans over several genes, the output will contain as many annotations lines as covered genes (cf example in FAQ). This latter annotation is extremely powerful to shorten the identification of mutation implicated in a specific gene. -The annotations columns available in the output file are detailed in the [README](../README.AnnotSV_latest.pdf). +The annotations columns available in the output file are detailed in the [README](../../../README.AnnotSV_3.4.pdf). diff --git a/share/tcl/AnnotSV/AnnotSV-benignsv.tcl b/share/tcl/AnnotSV/AnnotSV-benignsv.tcl index 964582a..e65a1f1 100644 --- a/share/tcl/AnnotSV/AnnotSV-benignsv.tcl +++ b/share/tcl/AnnotSV/AnnotSV-benignsv.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -1342,7 +1342,6 @@ proc checkCMRI_benignFile {genomeBuild} { if {$L_toWriteGain ne {}} { WriteTextInFile [join $L_toWriteGain "\n"] $benignGainFile_Tmp } - puts "\t ([llength $L_toWriteIns] INS + [llength $L_toWriteInv] INV)" if {$L_toWriteIns ne {}} { WriteTextInFile [join $L_toWriteIns "\n"] $benignInsFile_Tmp } diff --git a/share/tcl/AnnotSV/AnnotSV-candidategenes.tcl b/share/tcl/AnnotSV/AnnotSV-candidategenes.tcl index a460632..05c1ce0 100644 --- a/share/tcl/AnnotSV/AnnotSV-candidategenes.tcl +++ b/share/tcl/AnnotSV/AnnotSV-candidategenes.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-clingen.tcl b/share/tcl/AnnotSV/AnnotSV-clingen.tcl index 4fed972..1dfde4a 100644 --- a/share/tcl/AnnotSV/AnnotSV-clingen.tcl +++ b/share/tcl/AnnotSV/AnnotSV-clingen.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -21,6 +21,16 @@ # along with this program; If not, see . # ############################################################################################################ + +# ClinGenFileDownloaded: +######################## +# ftp://ftp.clinicalgenome.org/ClinGen_gene_curation_list_GRCh37.tsv +# Some genes are on chrom X AND chrom Y: +# CSF2RA 1438 Xp22.33 and Yp11.2 chrX:1387693-1428828 30 Gene associated with autosomal recessive phenotype 0 No evidence available 2021-08-23 MONDO:0012580 +# CSF2RA 1438 Xp22.33 and Yp11.2 chrY:1268814-1325218 30 Gene associated with autosomal recessive phenotype 0 No evidence available 2021-08-23 MONDO:0012580 +# => be carreful to avoid redundancy + + ## - Check if the "ClinGen_gene_curation_list_GRCh37.tsv" file exists. ## - Check and create if necessary the 'date'_ClinGenAnnotations.tsv file. proc checkClinGenFile {} { @@ -72,7 +82,11 @@ proc checkClinGenFile {} { set gene [lindex $Ls $i_gene] set HI [lindex $Ls $i_HI] set TS [lindex $Ls $i_TS] - + + # To avoir redundancy for genes (CSF2RA and VAMP7) presents on chrom X AND chrom Y + if {[info exists seen($gene)]} {continue} + set seen($gene) 1 + if {$HI eq "Not yet evaluated"} {set HI ""} if {$TS eq "Not yet evaluated"} {set TS ""} diff --git a/share/tcl/AnnotSV/AnnotSV-closestgenes.tcl b/share/tcl/AnnotSV/AnnotSV-closestgenes.tcl index dda620e..4f6eda8 100644 --- a/share/tcl/AnnotSV/AnnotSV-closestgenes.tcl +++ b/share/tcl/AnnotSV/AnnotSV-closestgenes.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-config.tcl b/share/tcl/AnnotSV/AnnotSV-config.tcl index 77df7f4..2fd96a0 100644 --- a/share/tcl/AnnotSV/AnnotSV-config.tcl +++ b/share/tcl/AnnotSV/AnnotSV-config.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-cosmic.tcl b/share/tcl/AnnotSV/AnnotSV-cosmic.tcl index 01fd788..17fb369 100644 --- a/share/tcl/AnnotSV/AnnotSV-cosmic.tcl +++ b/share/tcl/AnnotSV/AnnotSV-cosmic.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-cytoband.tcl b/share/tcl/AnnotSV/AnnotSV-cytoband.tcl index a998aa8..a1265eb 100644 --- a/share/tcl/AnnotSV/AnnotSV-cytoband.tcl +++ b/share/tcl/AnnotSV/AnnotSV-cytoband.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-encodeblacklist.tcl b/share/tcl/AnnotSV/AnnotSV-encodeblacklist.tcl index a71e18e..c1b5a46 100644 --- a/share/tcl/AnnotSV/AnnotSV-encodeblacklist.tcl +++ b/share/tcl/AnnotSV/AnnotSV-encodeblacklist.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-exac.tcl b/share/tcl/AnnotSV/AnnotSV-exac.tcl index a3b2a31..71e9d08 100644 --- a/share/tcl/AnnotSV/AnnotSV-exac.tcl +++ b/share/tcl/AnnotSV/AnnotSV-exac.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-exomiser.tcl b/share/tcl/AnnotSV/AnnotSV-exomiser.tcl index 5c1dacf..61e7528 100644 --- a/share/tcl/AnnotSV/AnnotSV-exomiser.tcl +++ b/share/tcl/AnnotSV/AnnotSV-exomiser.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-extann.tcl b/share/tcl/AnnotSV/AnnotSV-extann.tcl index e9560db..e411127 100644 --- a/share/tcl/AnnotSV/AnnotSV-extann.tcl +++ b/share/tcl/AnnotSV/AnnotSV-extann.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-filteredVCF.tcl b/share/tcl/AnnotSV/AnnotSV-filteredVCF.tcl index 6e14d37..277ad44 100644 --- a/share/tcl/AnnotSV/AnnotSV-filteredVCF.tcl +++ b/share/tcl/AnnotSV/AnnotSV-filteredVCF.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-gap.tcl b/share/tcl/AnnotSV/AnnotSV-gap.tcl index f5f4bbe..ecbbb7c 100644 --- a/share/tcl/AnnotSV/AnnotSV-gap.tcl +++ b/share/tcl/AnnotSV/AnnotSV-gap.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-gccontent.tcl b/share/tcl/AnnotSV/AnnotSV-gccontent.tcl index 8881a80..73ac317 100644 --- a/share/tcl/AnnotSV/AnnotSV-gccontent.tcl +++ b/share/tcl/AnnotSV/AnnotSV-gccontent.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-gencc.tcl b/share/tcl/AnnotSV/AnnotSV-gencc.tcl index a4cab90..e5b6da1 100644 --- a/share/tcl/AnnotSV/AnnotSV-gencc.tcl +++ b/share/tcl/AnnotSV/AnnotSV-gencc.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-general.tcl b/share/tcl/AnnotSV/AnnotSV-general.tcl index e3a5dc2..525ebcd 100644 --- a/share/tcl/AnnotSV/AnnotSV-general.tcl +++ b/share/tcl/AnnotSV/AnnotSV-general.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-genes.tcl b/share/tcl/AnnotSV/AnnotSV-genes.tcl index 63c4a1a..0613087 100644 --- a/share/tcl/AnnotSV/AnnotSV-genes.tcl +++ b/share/tcl/AnnotSV/AnnotSV-genes.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -195,6 +195,8 @@ proc transcriptVersionAnnotation {transcript_ID} { global g_AnnotSV global g_transcriptVersion + if {$g_AnnotSV(organism) ne "Human"} {set g_transcriptVersion(Done) 1} + if {![info exists g_transcriptVersion(Done)]} { set g_transcriptVersion(Done) 1 set genesDir "$g_AnnotSV(annotationsDir)/Annotations_$g_AnnotSV(organism)/Genes/$g_AnnotSV(genomeBuild)" diff --git a/share/tcl/AnnotSV/AnnotSV-haploinsufficiency.tcl b/share/tcl/AnnotSV/AnnotSV-haploinsufficiency.tcl index 1941c96..e2b0c34 100644 --- a/share/tcl/AnnotSV/AnnotSV-haploinsufficiency.tcl +++ b/share/tcl/AnnotSV/AnnotSV-haploinsufficiency.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-help.tcl b/share/tcl/AnnotSV/AnnotSV-help.tcl index 6bfbbc0..ca88d6e 100644 --- a/share/tcl/AnnotSV/AnnotSV-help.tcl +++ b/share/tcl/AnnotSV/AnnotSV-help.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-loeuf-pLI.tcl b/share/tcl/AnnotSV/AnnotSV-loeuf-pLI.tcl index 8701968..e71275d 100644 --- a/share/tcl/AnnotSV/AnnotSV-loeuf-pLI.tcl +++ b/share/tcl/AnnotSV/AnnotSV-loeuf-pLI.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-ncbi.tcl b/share/tcl/AnnotSV/AnnotSV-ncbi.tcl index 8850a8a..12568c4 100644 --- a/share/tcl/AnnotSV/AnnotSV-ncbi.tcl +++ b/share/tcl/AnnotSV/AnnotSV-ncbi.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-omim.tcl b/share/tcl/AnnotSV/AnnotSV-omim.tcl index b704fed..1dbaaca 100644 --- a/share/tcl/AnnotSV/AnnotSV-omim.tcl +++ b/share/tcl/AnnotSV/AnnotSV-omim.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-pathogenicsnvindel.tcl b/share/tcl/AnnotSV/AnnotSV-pathogenicsnvindel.tcl index 8557abf..e876a1f 100644 --- a/share/tcl/AnnotSV/AnnotSV-pathogenicsnvindel.tcl +++ b/share/tcl/AnnotSV/AnnotSV-pathogenicsnvindel.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-pathogenicsv.tcl b/share/tcl/AnnotSV/AnnotSV-pathogenicsv.tcl index a98e70a..5b2b9bf 100644 --- a/share/tcl/AnnotSV/AnnotSV-pathogenicsv.tcl +++ b/share/tcl/AnnotSV/AnnotSV-pathogenicsv.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -215,7 +215,7 @@ proc checkClinVar_PathogenicFile {genomeBuild} { # Writing: ########## - puts "\t ([llength $L_toWriteLoss] SV Loss + [llength $L_toWriteGain] SV Gain)" + puts "\t ([llength $L_toWriteLoss] SV Loss + [llength $L_toWriteGain] SV Gain + [llength $L_toWriteIns] SV Ins + [llength $L_toWriteInv] SV Inv)" if {$L_toWriteLoss ne {}} { WriteTextInFile [join $L_toWriteLoss "\n"] $pathogenicLossFile_Tmp } @@ -443,7 +443,7 @@ proc checkdbVar_PathogenicFile {genomeBuild} { # Writing: ########## - puts "\t ([llength $L_toWriteLoss] SV Loss + [llength $L_toWriteGain] SV Gain)" + puts "\t ([llength $L_toWriteLoss] SV Loss + [llength $L_toWriteGain] SV Gain + [llength $L_toWriteIns] SV Ins)" if {$L_toWriteLoss ne {}} { WriteTextInFile [join $L_toWriteLoss "\n"] $pathogenicLossFile_Tmp } @@ -483,7 +483,7 @@ proc checkOMIM_PathogenicFile {genomeBuild} { puts "\t >>> OMIM morbid genes parsing ([clock format [clock seconds] -format "%B %d %Y - %H:%M"])" # Genes coordinates - set genesDir "$g_AnnotSV(annotationsDir)/Annotations_$g_AnnotSV(organism)/Genes/$g_AnnotSV(genomeBuild)" + set genesDir "$g_AnnotSV(annotationsDir)/Annotations_$g_AnnotSV(organism)/Genes/$genomeBuild" set genesFileFormatted "[glob -nocomplain $genesDir/genes.$g_AnnotSV(tx).sorted.bed]" foreach L [LinesFromFile $genesFileFormatted] { set Ls [split $L "\t"] diff --git a/share/tcl/AnnotSV/AnnotSV-phenogenius.tcl b/share/tcl/AnnotSV/AnnotSV-phenogenius.tcl index 4fd7ba6..1050d2b 100644 --- a/share/tcl/AnnotSV/AnnotSV-phenogenius.tcl +++ b/share/tcl/AnnotSV/AnnotSV-phenogenius.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-ranking.tcl b/share/tcl/AnnotSV/AnnotSV-ranking.tcl index 413e7d5..82c13dc 100644 --- a/share/tcl/AnnotSV/AnnotSV-ranking.tcl +++ b/share/tcl/AnnotSV/AnnotSV-ranking.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-regulatoryelements.tcl b/share/tcl/AnnotSV/AnnotSV-regulatoryelements.tcl index 21c21f4..d249c01 100644 --- a/share/tcl/AnnotSV/AnnotSV-regulatoryelements.tcl +++ b/share/tcl/AnnotSV/AnnotSV-regulatoryelements.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -303,7 +303,6 @@ proc checkEAfiles {} { - ## - Check if the following GH files has been downloaded: ## - GeneHancer_elements.txt ## - GeneHancer_gene_associations_scores.txt diff --git a/share/tcl/AnnotSV/AnnotSV-repeat.tcl b/share/tcl/AnnotSV/AnnotSV-repeat.tcl index 2d72ef3..9baf9e0 100644 --- a/share/tcl/AnnotSV/AnnotSV-repeat.tcl +++ b/share/tcl/AnnotSV/AnnotSV-repeat.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-segdup.tcl b/share/tcl/AnnotSV/AnnotSV-segdup.tcl index 88cb253..9daa997 100644 --- a/share/tcl/AnnotSV/AnnotSV-segdup.tcl +++ b/share/tcl/AnnotSV/AnnotSV-segdup.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-tad.tcl b/share/tcl/AnnotSV/AnnotSV-tad.tcl index a2eec01..c479435 100644 --- a/share/tcl/AnnotSV/AnnotSV-tad.tcl +++ b/share/tcl/AnnotSV/AnnotSV-tad.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-userBED.tcl b/share/tcl/AnnotSV/AnnotSV-userBED.tcl index 13a97ce..694ea1b 100644 --- a/share/tcl/AnnotSV/AnnotSV-userBED.tcl +++ b/share/tcl/AnnotSV/AnnotSV-userBED.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-variantconvert.tcl b/share/tcl/AnnotSV/AnnotSV-variantconvert.tcl index aae138c..eee6464 100644 --- a/share/tcl/AnnotSV/AnnotSV-variantconvert.tcl +++ b/share/tcl/AnnotSV/AnnotSV-variantconvert.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-vcf.tcl b/share/tcl/AnnotSV/AnnotSV-vcf.tcl index 46f0f0c..6a36fe6 100644 --- a/share/tcl/AnnotSV/AnnotSV-vcf.tcl +++ b/share/tcl/AnnotSV/AnnotSV-vcf.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # diff --git a/share/tcl/AnnotSV/AnnotSV-write.tcl b/share/tcl/AnnotSV/AnnotSV-write.tcl index 267f955..ce8771d 100644 --- a/share/tcl/AnnotSV/AnnotSV-write.tcl +++ b/share/tcl/AnnotSV/AnnotSV-write.tcl @@ -1,5 +1,5 @@ ############################################################################################################ -# AnnotSV 3.3.9 # +# AnnotSV 3.4 # # # # AnnotSV: An integrated tool for Structural Variations annotation and ranking # # # @@ -909,9 +909,9 @@ proc OrganizeAnnotation {} { set L_cytobandText "[userBEDannotation $cytobandBEDfile $SVchrom $SVleft $SVright]" } set L_cytobandText [split $L_cytobandText ";"] - set cytobandText [lindex $L_cytobandText end] + set cytobandText [lindex $L_cytobandText 0] if {[llength $L_cytobandText] > 1} { - append cytobandText "-[lindex $L_cytobandText 0]" + append cytobandText "-[lindex $L_cytobandText end]" } } } diff --git a/tests/data/README b/tests/AnnotSV/README similarity index 100% rename from tests/data/README rename to tests/AnnotSV/README diff --git a/tests/data/scripts/check_all_public_test_directory.sh b/tests/AnnotSV/scripts/check_all_public_test_directory.sh similarity index 100% rename from tests/data/scripts/check_all_public_test_directory.sh rename to tests/AnnotSV/scripts/check_all_public_test_directory.sh diff --git a/tests/data/scripts/check_end_values.tcl b/tests/AnnotSV/scripts/check_end_values.tcl similarity index 100% rename from tests/data/scripts/check_end_values.tcl rename to tests/AnnotSV/scripts/check_end_values.tcl diff --git a/tests/data/scripts/check_includeCI.tcl b/tests/AnnotSV/scripts/check_includeCI.tcl similarity index 100% rename from tests/data/scripts/check_includeCI.tcl rename to tests/AnnotSV/scripts/check_includeCI.tcl diff --git a/tests/data/scripts/complete_KnotAnnotSV_YAML_test.tcl b/tests/AnnotSV/scripts/complete_KnotAnnotSV_YAML_test.tcl similarity index 100% rename from tests/data/scripts/complete_KnotAnnotSV_YAML_test.tcl rename to tests/AnnotSV/scripts/complete_KnotAnnotSV_YAML_test.tcl diff --git a/tests/data/scripts/cutWithColumnNames.tcl b/tests/AnnotSV/scripts/cutWithColumnNames.tcl similarity index 100% rename from tests/data/scripts/cutWithColumnNames.tcl rename to tests/AnnotSV/scripts/cutWithColumnNames.tcl diff --git a/tests/data/test_01_configfile/command_Tcl.sh b/tests/AnnotSV/test_01_configfile/command_Tcl.sh similarity index 97% rename from tests/data/test_01_configfile/command_Tcl.sh rename to tests/AnnotSV/test_01_configfile/command_Tcl.sh index ee75173..a1315b4 100755 --- a/tests/data/test_01_configfile/command_Tcl.sh +++ b/tests/AnnotSV/test_01_configfile/command_Tcl.sh @@ -43,13 +43,13 @@ then exit 1 fi -if [[ $minAnn > 71 ]] +if [[ $minAnn > 74 ]] then echo "error 1: too much annotation columns ($minAnn)" exit 1 fi -if [ $minAnn >= $allAnn ] +if [ $minAnn -ge $allAnn ] then echo "error 1: minimum of annotation columns not respected" exit 1 diff --git a/tests/data/test_01_configfile/input/test.bed b/tests/AnnotSV/test_01_configfile/input/test.bed similarity index 100% rename from tests/data/test_01_configfile/input/test.bed rename to tests/AnnotSV/test_01_configfile/input/test.bed diff --git a/tests/data/test_02_HG00096/command_Tcl.sh b/tests/AnnotSV/test_02_HG00096/command_Tcl.sh similarity index 100% rename from tests/data/test_02_HG00096/command_Tcl.sh rename to tests/AnnotSV/test_02_HG00096/command_Tcl.sh diff --git a/tests/data/test_02_HG00096/command_python.sh b/tests/AnnotSV/test_02_HG00096/command_python.sh similarity index 100% rename from tests/data/test_02_HG00096/command_python.sh rename to tests/AnnotSV/test_02_HG00096/command_python.sh diff --git a/tests/data/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.bed b/tests/AnnotSV/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.bed similarity index 100% rename from tests/data/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.bed rename to tests/AnnotSV/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.bed diff --git a/tests/data/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.vcf b/tests/AnnotSV/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.vcf similarity index 100% rename from tests/data/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.vcf rename to tests/AnnotSV/test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.vcf diff --git a/tests/data/test_03_CDSandTxCoverage/command_Tcl.sh b/tests/AnnotSV/test_03_CDSandTxCoverage/command_Tcl.sh similarity index 85% rename from tests/data/test_03_CDSandTxCoverage/command_Tcl.sh rename to tests/AnnotSV/test_03_CDSandTxCoverage/command_Tcl.sh index bd666a0..dabef41 100755 --- a/tests/data/test_03_CDSandTxCoverage/command_Tcl.sh +++ b/tests/AnnotSV/test_03_CDSandTxCoverage/command_Tcl.sh @@ -16,6 +16,8 @@ cut="$ANNOTSV/tests/data/scripts/cutWithColumnNames.tcl" ###################################### # # grep NM_000569 $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# 1 161511548 161519608 - FCGR3A NM_000569 161512801 161519526 161511548,161514490,161518210,161518800,161519486, 161512989,161514748,161518468,161518821,161519608, + # 1 161511549 161519608 - FCGR3A NM_000569 161512801 161519526 161511549,161514490,161518210,161518800,161519486, 161512989,161514748,161518468,161518821,161519608, # # Truth = input/test_tcl.annotated.tsv.truth.sauv diff --git a/tests/data/test_03_CDSandTxCoverage/input/control_9deletions_FCGR3A_NM_000569.bed b/tests/AnnotSV/test_03_CDSandTxCoverage/input/control_9deletions_FCGR3A_NM_000569.bed similarity index 100% rename from tests/data/test_03_CDSandTxCoverage/input/control_9deletions_FCGR3A_NM_000569.bed rename to tests/AnnotSV/test_03_CDSandTxCoverage/input/control_9deletions_FCGR3A_NM_000569.bed diff --git a/tests/AnnotSV/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv b/tests/AnnotSV/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv new file mode 100755 index 0000000..e25ce8e --- /dev/null +++ b/tests/AnnotSV/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv @@ -0,0 +1,19 @@ +AnnotSV_ID SV_chrom SV_start SV_end SV_length SV_type Samples_ID Annotation_mode CytoBand Gene_name Closest_left Closest_right Gene_count Tx Tx_version Tx_start Tx_end Overlapped_tx_length Overlapped_CDS_length Overlapped_CDS_percent Frameshift Exon_count Location Location2 Dist_nearest_SS Nearest_SS_type Intersect_start Intersect_end RE_gene P_gain_phen P_gain_hpo P_gain_source P_gain_coord P_loss_phen P_loss_hpo P_loss_source P_loss_coord P_ins_phen P_ins_hpo P_ins_source P_ins_coord po_P_gain_phen po_P_gain_hpo po_P_gain_source po_P_gain_coord po_P_gain_percent po_P_loss_phen po_P_loss_hpo po_P_loss_source po_P_loss_coord po_P_loss_percent P_snvindel_nb P_snvindel_phen B_gain_source B_gain_coord B_gain_AFmax B_loss_source B_loss_coord B_loss_AFmax B_ins_source B_ins_coord B_ins_AFmax B_inv_source B_inv_coord B_inv_AFmax po_B_gain_allG_source po_B_gain_allG_coord po_B_gain_someG_source po_B_gain_someG_coord po_B_loss_allG_source po_B_loss_allG_coord po_B_loss_someG_source po_B_loss_someG_coord Cosmic_ID Cosmic_mut_typ GC_content_left GC_content_right Repeat_coord_left Repeat_type_left Repeat_coord_right Repeat_type_right Gap_left Gap_right SegDup_left SegDup_right ENCODE_blacklist_left ENCODE_blacklist_characteristics_left ENCODE_blacklist_right ENCODE_blacklist_characteristics_right ACMG HI TS DDD_HI_percent ExAC_delZ ExAC_dupZ ExAC_cnvZ ExAC_synZ ExAC_misZ GenCC_disease GenCC_moi GenCC_classification GenCC_pmid NCBI_gene_ID OMIM_ID OMIM_phenotype OMIM_inheritance OMIM_morbid OMIM_morbid_candidate LOEUF_bin GnomAD_pLI ExAC_pLI AnnotSV_ranking_score AnnotSV_ranking_criteria ACMG_class +1_161511001_161514600_DEL_1 1 161511001 161514600 -3599 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 ATF6 (morbid/RE=EA_enhancer);MPZ (morbid/RE=EA_enhancer);SDHC (HI=3/morbid/RE=EA_enhancer) dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.01;0.02 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.04;0.14;0.05;0.02;0.02;0.06;33.99 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093; chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar 0.435 0.440 1:161510916-161511163 L2c 1:161479598-161518642 1:161479598-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2D-4 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +1_161511001_161514600_DEL_1 1 161511001 161514600 -3599 DEL NA split q23.3 FCGR3A NM_000569 8 161511548 161519608 3052 298 38 yes 5 exon4-txEnd CDS-3'UTR 110 5' 161511548 161514600 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 +1_161512501_161518300_DEL_1 1 161512501 161518300 -5799 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 ATF6 (morbid/RE=EA_enhancer);MPZ (morbid/RE=EA_enhancer);SDHC (HI=3/morbid/RE=EA_enhancer) dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.01;0.02;0.03 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.01;0.06;0.23;0.08;0.03;0.04;0.10;64.60 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093; chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar 0.360 0.545 1:161479598-161518642 1:161479598-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2D-4 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +1_161512501_161518300_DEL_1 1 161512501 161518300 -5799 DEL NA split q23.3 FCGR3A NM_000569 8 161511548 161519608 5800 536 70 yes 5 exon3-exon5 CDS-3'UTR 90 5' 161512500 161518300 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 +1_161518601_161519950_DEL_1 1 161518601 161519950 -1349 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.00;0.01 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.01;0.05;0.02;0.01;0.01;0.02;15.04 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093;chr1:161519612-161593482 dbVar;1:161519613-161593482 esv3587731 chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar;1:161519613-161593482 1000g 0.535 0.545 1:161479598-161518642;1:161518644-161565122 1:161518644-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +1_161518601_161519950_DEL_1 1 161518601 161519950 -1349 DEL NA split q23.3 FCGR3A NM_001127592 2 161511548 161519893 1293 376 34 yes 5 txStart-intron2 5'UTR-CDS 135 3' 161518600 161519893 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 +1_161518811_161519500_DEL_1 1 161518811 161519500 -689 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.00;0.00 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.01;0.03;0.01;0.00;0.00;0.01;7.68 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093; chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar 0.450 0.535 1:161518644-161565122 1:161518644-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2E-1 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +1_161518811_161519500_DEL_1 1 161518811 161519500 -689 DEL NA split q23.3 FCGR3A NM_000569 8 161511548 161519608 690 25 3 yes 5 exon1-exon2 CDS 10 5' 161518810 161519500 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 +1_161518811_161519850_DEL_1 1 161518811 161519850 -1039 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.00;0.01 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.01;0.04;0.01;0.01;0.01;0.02;11.58 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093;chr1:161519612-161593482 dbVar;1:161519613-161593482 esv3587731 chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar;1:161519613-161593482 1000g 0.450 0.570 1:161518644-161565122 1:161518644-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +1_161518811_161519850_DEL_1 1 161518811 161519850 -1039 DEL NA split q23.3 FCGR3A NM_001127592 2 161511548 161519893 1040 366 33 no 5 exon1-exon2 5'UTR-CDS 10 5' 161518810 161519850 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 +1_161511001_161512900_DEL_1 1 161511001 161512900 -1899 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.01;0.01 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.02;0.07;0.03;0.01;0.01;0.03;15.06 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093; chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar 0.435 0.425 1:161510916-161511163 L2c 1:161479598-161518642 1:161479598-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 0.45 1A (cf Gene_count, RE_gene, +0.00);2D-3 (FCGR3A, +0.45);3A (1 gene, +0.00);5F (+0.00) 3 +1_161511001_161512900_DEL_1 1 161511001 161512900 -1899 DEL NA split q23.3 FCGR3A NM_000569 8 161511548 161519608 1352 99 12 no 5 exon5-txEnd CDS-3'UTR 89 3' 161511548 161512900 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=3 +1_161511001_161511600_DEL_1 1 161511001 161511600 -599 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.00;0.00 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.01;0.02;0.01;0.00;0.00;0.01;0.58 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093; chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar 0.435 0.335 1:161510916-161511163 L2c 1:161511571-161511646 L3 1:161479598-161518642 1:161479598-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);2D-1 (FCGR3A,+0.00);3A (1 gene, +0.00);5F (+0.00) 1 +1_161511001_161511600_DEL_1 1 161511001 161511600 -599 DEL NA split q23.3 FCGR3A NM_000569 8 161511548 161519608 52 0 0 no 5 exon5-txEnd 3'UTR 1389 3' 161511548 161511600 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=1 +1_161511001_161519950_DEL_1 1 161511001 161519950 -8949 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 ATF6 (morbid/RE=EA_enhancer);MPZ (morbid/RE=EA_enhancer);SDHC (HI=3/morbid/RE=EA_enhancer) dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.01;0.03;0.05 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.01;0.09;0.35;0.12;0.05;0.06;0.15;93.57 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093;chr1:161519612-161593482 dbVar;1:161519613-161593482 esv3587731 chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar;1:161519613-161593482 1000g 0.435 0.545 1:161510916-161511163 L2c 1:161479598-161518642 1:161518644-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 +1_161511001_161519950_DEL_1 1 161511001 161519950 -8949 DEL NA split q23.3 FCGR3A NM_001127592 2 161511548 161519893 8345 1077 100 no 5 txStart-txEnd 5'UTR-3'UTR 161511548 161519893 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=1 +1_161512001_161512500_DEL_1 1 161512001 161512500 -499 DEL NA full q23.3 FCGR3A HSPA6 FCGR2C 1 dbVar:nssv15156967;dbVar:nssv15156970;dbVar:nssv15149867;nssv15151118;dbVar:nssv15127572;dbVar:nssv15148250;dbVar:nssv15133506 1:47852-249228449;1:82155-249218992;1:849468-249224684;1:145764500-249233096;1:149825832-180236332;1:157717037-175990383 0.00;0.00;0.00;0.00;0.00;0.00 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15777243;dbVar:nssv15143225;dbVar:nssv15132112;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv17970186;morbid:FCGR3A 1:146053395-249233096;1:157321300-167391423;1:159343439-161918472;1:159449678-166864323;1:159815643-177026983;1:160369891-175796325;1:160417297-166197042;1:161511549-161520527 0.00;0.00;0.02;0.01;0.00;0.00;0.01;5.57 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 1:161483000-161621200 gnomAD-SV_v2.1_DUP_1_2488;1:161488422-161634845 DDD:3093;1:161488445-161519959 1000g;1:161509489-161646576 nsv514915 chr1:161480422-161646940 dbVar;chr1:161484700-161541000 dbVar;chr1:161488444-161519959 dbVar;1:161488445-161519959 esv3587730 1:161488422-161634845 DDD:3093; chr1:161485000-161522125 dbVar;chr1:161488444-161519959 dbVar 0.490 0.360 1:161479598-161518642 1:161479598-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 8 3.6955e-06 1.2227e-05 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);2D-1 (FCGR3A,+0.00);3A (1 gene, +0.00);5F (+0.00) 1 +1_161512001_161512500_DEL_1 1 161512001 161512500 -499 DEL NA split q23.3 FCGR3A NM_000569 8 161511548 161519608 500 0 0 no 5 exon5-exon5 3'UTR 489 3' 161512000 161512500 1000g;DDD:3093;dbVar;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;nsv514915 chr1:161480422-161646940;1:161483000-161621200;chr1:161484700-161541000;1:161488422-161634845;chr1:161488444-161519959;1:161488445-161519959;1:161488445-161519959;1:161509489-161646576 0.1000 DDD:3093;dbVar chr1:161485000-161522125;1:161488422-161634845;chr1:161488444-161519959 0.0769 IMH 1:4599855-170869838;1:17124869-234920285;1:69129973-188838391;1:76428346-179322403;1:108097960-232960701 0.3095 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 2214 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=1 diff --git a/tests/data/test_04_ExternalBEDannotationFiles/command_Tcl.sh b/tests/AnnotSV/test_04_ExternalBEDannotationFiles/command_Tcl.sh similarity index 100% rename from tests/data/test_04_ExternalBEDannotationFiles/command_Tcl.sh rename to tests/AnnotSV/test_04_ExternalBEDannotationFiles/command_Tcl.sh diff --git a/tests/data/test_04_ExternalBEDannotationFiles/input/test.bed b/tests/AnnotSV/test_04_ExternalBEDannotationFiles/input/test.bed similarity index 100% rename from tests/data/test_04_ExternalBEDannotationFiles/input/test.bed rename to tests/AnnotSV/test_04_ExternalBEDannotationFiles/input/test.bed diff --git a/tests/data/test_04_ExternalBEDannotationFiles/input/user_FtIncludedInSV.bed b/tests/AnnotSV/test_04_ExternalBEDannotationFiles/input/user_FtIncludedInSV.bed similarity index 100% rename from tests/data/test_04_ExternalBEDannotationFiles/input/user_FtIncludedInSV.bed rename to tests/AnnotSV/test_04_ExternalBEDannotationFiles/input/user_FtIncludedInSV.bed diff --git a/tests/data/test_04_ExternalBEDannotationFiles/input/user_SVincludedInFt.bed b/tests/AnnotSV/test_04_ExternalBEDannotationFiles/input/user_SVincludedInFt.bed similarity index 100% rename from tests/data/test_04_ExternalBEDannotationFiles/input/user_SVincludedInFt.bed rename to tests/AnnotSV/test_04_ExternalBEDannotationFiles/input/user_SVincludedInFt.bed diff --git a/tests/data/test_05_BEDwithoutHeader/command_Tcl.sh b/tests/AnnotSV/test_05_BEDwithoutHeader/command_Tcl.sh similarity index 100% rename from tests/data/test_05_BEDwithoutHeader/command_Tcl.sh rename to tests/AnnotSV/test_05_BEDwithoutHeader/command_Tcl.sh diff --git a/tests/data/test_05_BEDwithoutHeader/input/test.bed b/tests/AnnotSV/test_05_BEDwithoutHeader/input/test.bed similarity index 100% rename from tests/data/test_05_BEDwithoutHeader/input/test.bed rename to tests/AnnotSV/test_05_BEDwithoutHeader/input/test.bed diff --git a/tests/data/test_05_BEDwithoutHeader/input/test.withoutHeader.bed b/tests/AnnotSV/test_05_BEDwithoutHeader/input/test.withoutHeader.bed similarity index 100% rename from tests/data/test_05_BEDwithoutHeader/input/test.withoutHeader.bed rename to tests/AnnotSV/test_05_BEDwithoutHeader/input/test.withoutHeader.bed diff --git a/tests/data/test_06_VCFfromLumpy/command_Tcl.sh b/tests/AnnotSV/test_06_VCFfromLumpy/command_Tcl.sh similarity index 100% rename from tests/data/test_06_VCFfromLumpy/command_Tcl.sh rename to tests/AnnotSV/test_06_VCFfromLumpy/command_Tcl.sh diff --git a/tests/data/test_06_VCFfromLumpy/input/test.DEL.DUP.vcf b/tests/AnnotSV/test_06_VCFfromLumpy/input/test.DEL.DUP.vcf similarity index 100% rename from tests/data/test_06_VCFfromLumpy/input/test.DEL.DUP.vcf rename to tests/AnnotSV/test_06_VCFfromLumpy/input/test.DEL.DUP.vcf diff --git a/tests/data/test_06_VCFfromLumpy/input/test1.csv b/tests/AnnotSV/test_06_VCFfromLumpy/input/test1.csv similarity index 100% rename from tests/data/test_06_VCFfromLumpy/input/test1.csv rename to tests/AnnotSV/test_06_VCFfromLumpy/input/test1.csv diff --git a/tests/data/test_06_VCFfromLumpy/input/test1.vcf b/tests/AnnotSV/test_06_VCFfromLumpy/input/test1.vcf similarity index 100% rename from tests/data/test_06_VCFfromLumpy/input/test1.vcf rename to tests/AnnotSV/test_06_VCFfromLumpy/input/test1.vcf diff --git a/tests/data/test_07_RegulatoryElement/command_Tcl.sh b/tests/AnnotSV/test_07_RegulatoryElement/command_Tcl.sh similarity index 91% rename from tests/data/test_07_RegulatoryElement/command_Tcl.sh rename to tests/AnnotSV/test_07_RegulatoryElement/command_Tcl.sh index 0301162..f1ffa0b 100755 --- a/tests/data/test_07_RegulatoryElement/command_Tcl.sh +++ b/tests/AnnotSV/test_07_RegulatoryElement/command_Tcl.sh @@ -30,8 +30,9 @@ rm -f "./output/delSOX9_tcl.annotated.tsv" $ANNOTSV/bin/AnnotSV -SVinputFile "./input/delSOX9.bed" -hpo "HP:0000278;HP:0000175" -outputFile "./output/delSOX9_tcl.annotated.tsv" -svtBEDcol 4 -REreport 1 -genomeBuild GRCh37 # Check that the "SOX9 RE" is annotated +# SOX9 (HI=3/EX=0.9959/morbid/RE=ABC_enhancer+GH_enhancer) val=`$cut "./output/delSOX9_tcl.annotated.tsv" "RE_gene"` -if [ `echo $val | egrep -c ";SOX9 \(EX=0.9.{3}/morbid/RE=GH_Enhancer\);"` != 1 ] +if [ `echo $val | egrep -c ";SOX9 \(HI=3/EX=0.9.{3}/morbid/RE=ABC_enhancer\+GH_enhancer\);"` != 1 ] then echo "error1: The SOX9 RE is not annotated!" exit 1 @@ -61,7 +62,8 @@ $ANNOTSV/bin/AnnotSV -SVinputFile "./input/delMEF2C.bed" -outputFile "./output/d # Check that the "MEF2C RE" is annotated val=`$cut "./output/delMEF2C_tcl.annotated.tsv" "RE_gene"` -if [ `echo $val | egrep -c ";MEF2C \(HI=3/morbid/candidate/RE=EA_enhancer\+GH_Enhancer\)"` != 1 ] +# ;MEF2C (HI=3/morbid/candidate/RE=EA_enhancer+GH_enhancer); +if [ `echo $val | egrep -c ";MEF2C \(HI=3/morbid/candidate/RE=EA_enhancer\+GH_enhancer\)"` != 1 ] then echo "error1: The MEF2C RE is not annotated!" exit 1 diff --git a/tests/data/test_07_RegulatoryElement/input/candidateGenesFile.txt b/tests/AnnotSV/test_07_RegulatoryElement/input/candidateGenesFile.txt similarity index 100% rename from tests/data/test_07_RegulatoryElement/input/candidateGenesFile.txt rename to tests/AnnotSV/test_07_RegulatoryElement/input/candidateGenesFile.txt diff --git a/tests/data/test_07_RegulatoryElement/input/delMEF2C.bed b/tests/AnnotSV/test_07_RegulatoryElement/input/delMEF2C.bed similarity index 100% rename from tests/data/test_07_RegulatoryElement/input/delMEF2C.bed rename to tests/AnnotSV/test_07_RegulatoryElement/input/delMEF2C.bed diff --git a/tests/data/test_07_RegulatoryElement/input/delSOX9.bed b/tests/AnnotSV/test_07_RegulatoryElement/input/delSOX9.bed similarity index 100% rename from tests/data/test_07_RegulatoryElement/input/delSOX9.bed rename to tests/AnnotSV/test_07_RegulatoryElement/input/delSOX9.bed diff --git a/tests/data/test_08_largeSV/command_Tcl.sh b/tests/AnnotSV/test_08_largeSV/command_Tcl.sh similarity index 100% rename from tests/data/test_08_largeSV/command_Tcl.sh rename to tests/AnnotSV/test_08_largeSV/command_Tcl.sh diff --git a/tests/data/test_08_largeSV/input/test.bed b/tests/AnnotSV/test_08_largeSV/input/test.bed similarity index 100% rename from tests/data/test_08_largeSV/input/test.bed rename to tests/AnnotSV/test_08_largeSV/input/test.bed diff --git a/tests/data/test_09_InsertionInAgene/command_Tcl.sh b/tests/AnnotSV/test_09_InsertionInAgene/command_Tcl.sh similarity index 100% rename from tests/data/test_09_InsertionInAgene/command_Tcl.sh rename to tests/AnnotSV/test_09_InsertionInAgene/command_Tcl.sh diff --git a/tests/data/test_09_InsertionInAgene/input/test.bed b/tests/AnnotSV/test_09_InsertionInAgene/input/test.bed similarity index 100% rename from tests/data/test_09_InsertionInAgene/input/test.bed rename to tests/AnnotSV/test_09_InsertionInAgene/input/test.bed diff --git a/tests/data/test_10_BadVCFformat/command_Tcl.sh b/tests/AnnotSV/test_10_BadVCFformat/command_Tcl.sh similarity index 100% rename from tests/data/test_10_BadVCFformat/command_Tcl.sh rename to tests/AnnotSV/test_10_BadVCFformat/command_Tcl.sh diff --git a/tests/data/test_10_BadVCFformat/input/testTRA.vcf b/tests/AnnotSV/test_10_BadVCFformat/input/testTRA.vcf similarity index 100% rename from tests/data/test_10_BadVCFformat/input/testTRA.vcf rename to tests/AnnotSV/test_10_BadVCFformat/input/testTRA.vcf diff --git a/tests/data/test_10_BadVCFformat/input/testVCFwithoutHeader.vcf b/tests/AnnotSV/test_10_BadVCFformat/input/testVCFwithoutHeader.vcf similarity index 100% rename from tests/data/test_10_BadVCFformat/input/testVCFwithoutHeader.vcf rename to tests/AnnotSV/test_10_BadVCFformat/input/testVCFwithoutHeader.vcf diff --git a/tests/data/test_11_RamTracking/README b/tests/AnnotSV/test_11_RamTracking/README similarity index 100% rename from tests/data/test_11_RamTracking/README rename to tests/AnnotSV/test_11_RamTracking/README diff --git a/tests/data/test_11_RamTracking/commandAnnotSV.sh b/tests/AnnotSV/test_11_RamTracking/commandAnnotSV.sh similarity index 100% rename from tests/data/test_11_RamTracking/commandAnnotSV.sh rename to tests/AnnotSV/test_11_RamTracking/commandAnnotSV.sh diff --git a/tests/data/test_11_RamTracking/command_Tcl.sh b/tests/AnnotSV/test_11_RamTracking/command_Tcl.sh similarity index 100% rename from tests/data/test_11_RamTracking/command_Tcl.sh rename to tests/AnnotSV/test_11_RamTracking/command_Tcl.sh diff --git a/tests/data/test_11_RamTracking/input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz b/tests/AnnotSV/test_11_RamTracking/input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz similarity index 100% rename from tests/data/test_11_RamTracking/input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz rename to tests/AnnotSV/test_11_RamTracking/input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz diff --git a/tests/AnnotSV/test_11_RamTracking/ramAnnotSV-ena-ram.txt 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+338052 +339040 +339780 +340980 +342248 +343172 +344436 +345452 +346696 +347880 +349104 +350380 +351624 +352808 +354016 +355512 +356744 +357784 +359240 +360912 +362148 +363124 +364368 +365660 +367188 +367972 +369216 +370372 +371444 +372492 +373876 +374644 +375532 +376496 +377264 +378276 +379420 +380336 +381532 +388824 +397352 +402248 +393824 +393824 +393824 +393824 + 0 diff --git a/tests/AnnotSV/test_11_RamTracking/tutu.log b/tests/AnnotSV/test_11_RamTracking/tutu.log new file mode 100644 index 0000000..d68d040 --- /dev/null +++ b/tests/AnnotSV/test_11_RamTracking/tutu.log @@ -0,0 +1,157 @@ +AnnotSV 3.4 + +Copyright (C) 2017-2024 GEOFFROY Veronique + +Please feel free to create a Github issue for any suggestions or bug reports (https://github.com/lgmgeo/AnnotSV/issues) + +Tcl/Tk version: 8.6 + +Application name used: +/gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4 + + +...downloading the configuration data (February 19 2024 - 15:08) + ...configuration data by default + ...configuration data from /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4/etc/AnnotSV/configfile + ...configuration data given in arguments + ...checking all these configuration data + +...checking the annotation data sources (February 19 2024 - 15:08) + +...listing arguments + ****************************************** + AnnotSV has been run with these arguments: + ****************************************** + -PhenoGenius 0 + -REreport 0 + -REselect1 1 + -REselect2 1 + -SVinputFile ../test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.bed + -SVinputInfo 1 + -SVminSize 50 + -annotationMode both + -annotationsDir /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4/share/AnnotSV + -bcftools bcftools + -bedtools bedtools + -benignAF 0.01 + -candidateGenesFiltering 0 + -cytoband 1 + -genomeBuild GRCh37 + -includeCI 1 + -metrics us + -miRNAann 1 + -minTotalNumber 500 + -organism Human + -outputDir /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4/tests/data/test_11_RamTracking/output + -outputFile HG00096.SV_tcl.annotated.tsv + -overlap 100 + -overwrite 1 + -promoterSize 500 + -rankFiltering 1 2 3 4 5 NA + -reciprocal 0 + -samplesidBEDcol 5 + -snvIndelFiles ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz + -snvIndelPASS 0 + -snvIndelSamples HG00096 + -svtBEDcol -1 + -tx RefSeq + -variantconvertDir /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4/share/python3/variantconvert/ + -vcf 0 + ****************************************** + +...searching for SV overlaps with a gene or a regulatory elements + ...1399 genes overlapped with an SV + ...5812 genes regulated by a regulatory element which is overlapped with an SV + +WARNING: "SV_type" annotation is missing: +****************************************** +AnnotSV_ID SV_chrom SV_start SV_end SV_length user#1 Samples_ID Annotation_mode CytoBand Gene_name Closest_left Closest_right Gene_count Tx Tx_version Tx_start Tx_end Overlapped_tx_length Overlapped_CDS_length Overlapped_CDS_percent Frameshift Exon_count Location Location2 Dist_nearest_SS Nearest_SS_type Intersect_start Intersect_end RE_gene P_gain_phen P_gain_hpo P_gain_source P_gain_coord P_loss_phen P_loss_hpo P_loss_source P_loss_coord P_ins_phen P_ins_hpo P_ins_source P_ins_coord po_P_gain_phen po_P_gain_hpo po_P_gain_source po_P_gain_coord po_P_gain_percent po_P_loss_phen po_P_loss_hpo po_P_loss_source po_P_loss_coord po_P_loss_percent P_snvindel_nb P_snvindel_phen B_gain_source B_gain_coord B_gain_AFmax B_loss_source B_loss_coord B_loss_AFmax B_ins_source B_ins_coord B_ins_AFmax B_inv_source B_inv_coord B_inv_AFmax po_B_gain_allG_source po_B_gain_allG_coord po_B_gain_someG_source po_B_gain_someG_coord po_B_loss_allG_source po_B_loss_allG_coord po_B_loss_someG_source po_B_loss_someG_coord Count_hom(HG00096) Count_htz(HG00096) Count_htz/allHom(HG00096) Count_htz/total(cohort) Count_total(cohort) Cosmic_ID Cosmic_mut_typ GC_content_left GC_content_right Repeat_coord_left Repeat_type_left Repeat_coord_right Repeat_type_right Gap_left Gap_right SegDup_left SegDup_right ENCODE_blacklist_left ENCODE_blacklist_characteristics_left ENCODE_blacklist_right ENCODE_blacklist_characteristics_right ACMG HI TS DDD_HI_percent ExAC_delZ ExAC_dupZ ExAC_cnvZ ExAC_synZ ExAC_misZ GenCC_disease GenCC_moi GenCC_classification GenCC_pmid NCBI_gene_ID OMIM_ID OMIM_phenotype OMIM_inheritance OMIM_morbid OMIM_morbid_candidate LOEUF_bin GnomAD_pLI ExAC_pLI +****************************************** + => No ranking provided + + +WARNING: AnnotSV requires the SV type (duplication, deletion...) to classify the SV + Not provided (svtBEDcol = -1) + => No SV ranking (ACMG_class feature will be set to "NA") + +...listing of the annotations to be realized (February 19 2024 - 15:08) + ...CytoBand annotation + ...Genes annotation + ...RefSeq annotation + ...Regulatory elements annotations + ...Promoter annotations + ...EnhancerAtlas annotations + ...GeneHancer annotations + ...MiRTargetLink annotations + ...ABC annotations + ...MPRA annotations + ...Annotations with pathogenic genes or genomic regions + ...dbVar annotation + ...ClinVar annotation + ...ClinGen annotation + ...Annotations with pathogenic snv/indel + ...Annotations with benign genes or genomic regions + ...gnomAD annotation + ...ClinVar annotation + ...ClinGen annotation + ...DGV annotation + ...DDD annotation + ...1000g annotation + ...Ira M. Hall's lab annotation + ...Children’s Mercy Research Institute + ...Annotations with features overlapped with the SV (100 %) + ...CosmicCompleteCNA_GRCh37.sorted.formatted.sorted.bed + (2 annotations columns: Cosmic_ID, Cosmic_mut_typ) + ...Annotations with features sharing any overlap with the SV + ...Breakpoints annotations + ...GC content annotation + ...Repeat annotation + ...Gap annotation + ...Segmental duplication annotation + ...ENCODE blacklist annotation + ...Gene-based annotations + ...20230622_ACMG.tsv + (81 gene identifiers and 1 annotations columns: ACMG) + ...20240216_ClinGenAnnotations.tsv.gz + (1528 gene identifiers and 2 annotations columns: HI, TS) + ...20200713_HI.tsv.gz + (19124 gene identifiers and 1 annotations columns: DDD_HI_percent) + ...20191219_ExAC.CNV-Zscore.annotations.tsv.gz + (15673 gene identifiers and 3 annotations columns: ExAC_delZ, ExAC_dupZ, ExAC_cnvZ) + ...20201023_GeneIntolerance-Zscore.annotations.tsv.gz + (18241 gene identifiers and 2 annotations columns: ExAC_synZ, ExAC_misZ) + ...20240216_GenCC.tsv.gz + (5140 gene identifiers and 4 annotations columns: GenCC_disease, GenCC_moi, GenCC_classification, GenCC_pmid) + ...geneSymbol_NCBIgeneID.tsv + (100939 gene identifiers and 1 annotations columns: NCBI_gene_ID) + ...20240216_OMIM-1-annotations.tsv.gz + (4901 gene identifiers and 1 annotations columns: OMIM_ID) + ...20240216_OMIM-2-annotations.tsv.gz + (4901 gene identifiers and 2 annotations columns: OMIM_phenotype, OMIM_inheritance) + ...20240216_morbid.tsv.gz + (13716 gene identifiers and 1 annotations columns: OMIM_morbid) + ...20240216_morbidCandidate.tsv.gz + (3582 gene identifiers and 1 annotations columns: OMIM_morbid_candidate) + ...20201106_gnomAD.LOEUF.pLI.annotations.tsv.gz + (19451 gene identifiers and 3 annotations columns: LOEUF_bin, GnomAD_pLI, ExAC_pLI) + +...annotation in progress (February 19 2024 - 15:08) + + +...parsing of snvIndelFiles for "HG00096" (February 19 2024 - 15:09) + ...split multiallelic sites into multiple rows for ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz (February 19 2024 - 15:09) + -- VCFannotation -- + bcftools norm -m -both ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz > /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4/tests/data/test_11_RamTracking/output/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz.1708351767.separate.vcf + Error: wrong number of fields in INFO/DP at 1:15274, expected 2, found 1 + => No multiallelic treatment done. + ...parsing of ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz (February 19 2024 - 15:09) + -> 44 SNV/indel located in all the SV (potentially with redundancy depending on SV overlap) + -> 44 SNV/indel loaded + +...writing of /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.4/tests/data/test_11_RamTracking/output/HG00096.SV_tcl.annotated.tsv (February 19 2024 - 15:09) + +...output columns annotation (February 19 2024 - 15:09): + AnnotSV_ID;SV_chrom;SV_start;SV_end;SV_length;user#1;Samples_ID;Annotation_mode;CytoBand;Gene_name;Closest_left;Closest_right;Gene_count;Tx;Tx_version;Tx_start;Tx_end;Overlapped_tx_length;Overlapped_CDS_length;Overlapped_CDS_percent;Frameshift;Exon_count;Location;Location2;Dist_nearest_SS;Nearest_SS_type;Intersect_start;Intersect_end;RE_gene;P_gain_phen;P_gain_hpo;P_gain_source;P_gain_coord;P_loss_phen;P_loss_hpo;P_loss_source;P_loss_coord;P_ins_phen;P_ins_hpo;P_ins_source;P_ins_coord;po_P_gain_phen;po_P_gain_hpo;po_P_gain_source;po_P_gain_coord;po_P_gain_percent;po_P_loss_phen;po_P_loss_hpo;po_P_loss_source;po_P_loss_coord;po_P_loss_percent;P_snvindel_nb;P_snvindel_phen;B_gain_source;B_gain_coord;B_gain_AFmax;B_loss_source;B_loss_coord;B_loss_AFmax;B_ins_source;B_ins_coord;B_ins_AFmax;B_inv_source;B_inv_coord;B_inv_AFmax;po_B_gain_allG_source;po_B_gain_allG_coord;po_B_gain_someG_source;po_B_gain_someG_coord;po_B_loss_allG_source;po_B_loss_allG_coord;po_B_loss_someG_source;po_B_loss_someG_coord;Count_hom(HG00096);Count_htz(HG00096);Count_htz/allHom(HG00096);Count_htz/total(cohort);Count_total(cohort);Cosmic_ID;Cosmic_mut_typ;GC_content_left;GC_content_right;Repeat_coord_left;Repeat_type_left;Repeat_coord_right;Repeat_type_right;Gap_left;Gap_right;SegDup_left;SegDup_right;ENCODE_blacklist_left;ENCODE_blacklist_characteristics_left;ENCODE_blacklist_right;ENCODE_blacklist_characteristics_right;ACMG;HI;TS;DDD_HI_percent;ExAC_delZ;ExAC_dupZ;ExAC_cnvZ;ExAC_synZ;ExAC_misZ;GenCC_disease;GenCC_moi;GenCC_classification;GenCC_pmid;NCBI_gene_ID;OMIM_ID;OMIM_phenotype;OMIM_inheritance;OMIM_morbid;OMIM_morbid_candidate;LOEUF_bin;GnomAD_pLI;ExAC_pLI;AnnotSV_ranking_score;AnnotSV_ranking_criteria;ACMG_class + + +...AnnotSV is done with the analysis (February 19 2024 - 15:09) diff --git a/tests/data/test_12_SpaceSeparatedBED/command_Tcl.sh b/tests/AnnotSV/test_12_SpaceSeparatedBED/command_Tcl.sh similarity index 100% rename from tests/data/test_12_SpaceSeparatedBED/command_Tcl.sh rename to tests/AnnotSV/test_12_SpaceSeparatedBED/command_Tcl.sh diff --git a/tests/data/test_12_SpaceSeparatedBED/input/space-separated.NA.bed b/tests/AnnotSV/test_12_SpaceSeparatedBED/input/space-separated.NA.bed similarity index 100% rename from tests/data/test_12_SpaceSeparatedBED/input/space-separated.NA.bed rename to tests/AnnotSV/test_12_SpaceSeparatedBED/input/space-separated.NA.bed diff --git a/tests/data/test_12_SpaceSeparatedBED/input/space-separated.bed b/tests/AnnotSV/test_12_SpaceSeparatedBED/input/space-separated.bed similarity index 100% rename from tests/data/test_12_SpaceSeparatedBED/input/space-separated.bed rename to tests/AnnotSV/test_12_SpaceSeparatedBED/input/space-separated.bed diff --git a/tests/data/test_12_SpaceSeparatedBED/input/tab-separated.bed b/tests/AnnotSV/test_12_SpaceSeparatedBED/input/tab-separated.bed similarity index 100% rename from tests/data/test_12_SpaceSeparatedBED/input/tab-separated.bed rename to tests/AnnotSV/test_12_SpaceSeparatedBED/input/tab-separated.bed diff --git a/tests/AnnotSV/test_13_txFile/command_Tcl.sh b/tests/AnnotSV/test_13_txFile/command_Tcl.sh new file mode 100755 index 0000000..3018f3d --- /dev/null +++ b/tests/AnnotSV/test_13_txFile/command_Tcl.sh @@ -0,0 +1,142 @@ +#!/bin/bash -x + +set -eo pipefail + +cut="$ANNOTSV/tests/data/scripts/cutWithColumnNames.tcl" + + +################################ +# Check the "-txFile" option +################################ + +# INFO: Transcript annotation comes from $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed + + +## Check 1: the CDK11B gene (with a BED input file) +################################################### + +# grep CDK11B $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# 1 1570602 1590465 - CDK11B NM_001291345 1571125 1588935 1570602,1571298,1571694,1572043,1572258,1572442,1572769,1573123,1573861,1575637,1576408,1577022,1577266,1577746,1580486,1586824,1588824,1590374, 1571218,1571488,1571843,1572160,1572366,1572564,1572875,1573245,1573952,1575813,1576474,1577181,1577362,1577869,1580625,1586938,1588948,1590465, +# 1 1570602 1590465 - CDK11B NM_001787 1571125 1588935 1570602,1571298,1571694,1572043,1572258,1572442,1572769,1573123,1573861,1575637,1576408,1577022,1577266,1577707,1580486,1586818,1588824,1590374, 1571218,1571488,1571843,1572160,1572366,1572564,1572875,1573245,1573952,1575813,1576474,1577181,1577362,1577869,1580625,1586938,1588948,1590465, +# 1 1570602 1590465 - CDK11B NM_033486 1571125 1588935 1570602,1571298,1571694,1572043,1572258,1572442,1572769,1573123,1573861,1575637,1576408,1577022,1577266,1577746,1580486,1586818,1588824,1590374, 1571218,1571488,1571843,1572160,1572366,1572564,1572875,1573245,1573952,1575813,1576474,1577181,1577362,1577869,1580625,1586938,1588948,1590465, +# 1 1570602 1590465 - CDK11B NM_033487 1571125 1577348 1570602,1571298,1571694,1572043,1572258,1572442,1572769,1573123,1573861,1575637,1576408,1577022,1577266,1586817,1588824,1590374, 1571218,1571488,1571843,1572160,1572366,1572564,1572875,1573245,1573952,1575813,1576474,1577181,1577365,1586938,1588948,1590465, +# 1 1570602 1590465 - CDK11B NM_033489 1571125 1588714 1570602,1571298,1571694,1572043,1572258,1572442,1572769,1573123,1573861,1575637,1576408,1577022,1577266,1577746,1580486,1586818,1588705,1588824,1590374, 1571218,1571488,1571843,1572160,1572366,1572564,1572875,1573245,1573952,1575813,1576474,1577181,1577362,1577869,1580625,1586938,1588752,1588948,1590465, +# 1 1570602 1590465 - CDK11B NM_033490 1571125 1577849 1570602,1571298,1571694,1572043,1572258,1572442,1572769,1573123,1573861,1575637,1576408,1577022,1577266,1577746,1586817,1588824,1590374, 1571218,1571488,1571843,1572160,1572366,1572564,1572875,1573245,1573952,1575813,1576474,1577181,1577362,1577871,1586938,1588948,1590465, + +# By default, the CDK11B gene is annotated with the "NM_001787" transcript (and not the "NM_033486") +rm -f "./output/test.check1_tcl.annotated.tsv" +$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check1_tcl.annotated.tsv" -svtBEDcol 5 -genomeBuild GRCh37 +annotations=`$cut "./output/test.check1_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` +if [ `echo $annotations | grep -c "NM_001787"` != 0 ] +then + echo "Ok" +else + echo "error 1: the CDK11B gene is not annotated with the NM_001787 transcript" + exit 1 +fi + + +# Changing of the transcript default: +# => "NM_033486" transcript is given in the "txFile.check1.txt" file +rm -f "./output/test.check1.WithTx_tcl.annotated.tsv" +$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check1.WithTx_tcl.annotated.tsv" -svtBEDcol 5 -txFile "./input/txFile.check1.txt" -genomeBuild GRCh37 +annotations=`$cut "./output/test.check1.WithTx_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` +#=> Now, the CDK11B gene is annotated with "NM_033486" +if [ `echo $annotations | grep -c "NM_033486"` != 0 ] +then + echo "Ok" +else + echo "error 1: the CDK11B gene is not annotated with the NM_033486 transcript" + exit 1 +fi + + +## Check 2: the NAV1 gene (with a VCF input file) +################################################# + +# grep NAV1 $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# 1 201508254 201796097 + NAV1 NM_001389615 201592012 201789060 201508254,201557666,201591980,201598531,201617761,201681944,201687517,201749548,201750139,201751303,201752533,201754437,201755556,201758867,201759816,201762919,201763593,201772720,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201508470,201557777,201592734,201598635,201618553,201682047,201687883,201749687,201750437,201751997,201752980,201754479,201755705,201758920,201759894,201763003,201763705,201772842,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201508254 201796097 + NAV1 NM_001389616 201592012 201789060 201508254,201591980,201598531,201617761,201681944,201687517,201749548,201750139,201751303,201752533,201754437,201755556,201758867,201759681,201759816,201762919,201763593,201772720,201773616,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201508470,201592734,201598635,201618553,201682047,201687883,201749687,201750437,201751997,201752980,201754479,201755705,201758920,201759705,201759894,201763003,201763705,201772842,201773625,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201508254 201796097 + NAV1 NM_001389617 201592012 201789060 201508254,201557666,201591980,201598531,201617761,201681944,201687517,201749548,201750139,201751303,201752533,201754437,201755556,201757595,201758867,201759681,201759816,201762919,201763593,201772720,201773616,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201508470,201557777,201592734,201598635,201618553,201682047,201687883,201749687,201750437,201751997,201752980,201754479,201755705,201757766,201758920,201759705,201759894,201763003,201763705,201772842,201773625,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201617793 201796097 + NAV1 NM_020443 201617796 201789060 201617793,201681944,201687517,201749548,201750139,201751303,201752533,201754437,201755556,201757595,201758867,201759681,201759816,201762919,201763593,201772720,201773616,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201618553,201682047,201687883,201749687,201750437,201751997,201752980,201754479,201755705,201757766,201758920,201759705,201759894,201763003,201763705,201772842,201773625,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201709027 201796097 + NAV1 NM_001167738 201709151 201789060 201709027,201749548,201750139,201751303,201752533,201754437,201755556,201757595,201758867,201759681,201759816,201762919,201763593,201772720,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201709204,201749687,201750437,201751997,201752980,201754479,201755705,201757766,201758920,201759705,201759894,201763003,201763705,201772842,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201709027 201796097 + NAV1 NM_001389611 201709151 201789060 201709027,201749548,201750139,201751303,201752533,201754437,201755556,201757595,201758867,201759681,201759816,201762919,201763593,201772720,201773616,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201709204,201749687,201750437,201751997,201752980,201754479,201755705,201757766,201758920,201759705,201759894,201763003,201763705,201772842,201773625,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201709027 201796097 + NAV1 NM_001389612 201709151 201789060 201709027,201749548,201750139,201751303,201752533,201754437,201755556,201757595,201758867,201759816,201762919,201763593,201772720,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201709204,201749687,201750437,201751997,201752980,201754479,201755705,201757766,201758920,201759894,201763003,201763705,201772842,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201709027 201796097 + NAV1 NM_001389613 201709151 201789060 201709027,201749548,201750139,201751303,201752533,201754437,201755556,201758867,201759681,201759816,201762919,201763593,201772720,201773616,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201709204,201749687,201750437,201751997,201752980,201754479,201755705,201758920,201759705,201759894,201763003,201763705,201772842,201773625,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, +# 1 201709027 201796097 + NAV1 NM_001389614 201709151 201789060 201709027,201749548,201750139,201751303,201752533,201754437,201755556,201758867,201759816,201762919,201763593,201772720,201777080,201777545,201777830,201778291,201778569,201779073,201779650,201780730,201781030,201781592,201782267,201786215,201788964, 201709204,201749687,201750437,201751997,201752980,201754479,201755705,201758920,201759894,201763003,201763705,201772842,201777277,201777738,201777999,201778389,201778665,201779233,201779886,201780885,201781102,201781789,201782386,201786413,201796097, + +# By default, the NAV1 gene is annotated with the "NM_001389615" transcript (and not the "NM_001167738") +rm -f "./output/test.check2_tcl.annotated.tsv" +$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check2.vcf" -outputFile "./output/test.check2_tcl.annotated.tsv" -genomeBuild GRCh37 +annotations=`$cut "./output/test.check2_tcl.annotated.tsv" "Gene_name;Tx" | grep "NAV1"` +if [ `echo $annotations | grep -c "NM_001389615"` != 0 ] +then + echo "Ok" +else + echo "error 1: the NAV1 gene is not annotated with the NM_001389615 transcript" + exit 1 +fi + + +# Changing of the transcript default: +# => "NM_001167738" transcript is given in the "txfile.check2.txt" file +rm -f "./output/test.check2.WithTx_tcl.annotated.tsv" +$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check2.vcf" -outputFile "./output/test.check2.WithTx_tcl.annotated.tsv" -txFile "./input/txFile.check2.txt" -genomeBuild GRCh37 +annotations=`$cut "./output/test.check2.WithTx_tcl.annotated.tsv" "Gene_name;Tx" | grep "NAV1"` +#=> Now, the NAV1 gene is annotated with "NM_001167738" +if [ `echo $annotations | grep -c "NM_001167738"` != 0 ] +then + echo "Ok" +else + echo "error 1: the NAV1 gene is not annotated with the NM_001167738 transcript" + exit 1 +fi + + + +############################ +# Check the "-tx" option +############################ + +## Check 3 +########## + +# By default, tx="RefSeq" +# Check with tx="ENSEMBL" +rm -f "./output/test.check3_tcl.annotated.tsv" +$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check3_tcl.annotated.tsv" -svtBEDcol 5 -tx "ENSEMBL" -genomeBuild GRCh37 +annotations=`$cut "./output/test.check3_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` +if [ `echo $annotations | grep -c "ENST00000407249"` != 0 ] +then + echo "Ok" +else + echo "error 1: the CDK11B gene is not annotated with the ENST00000407249 transcript" + exit 1 +fi + + +# Changing of the transcript default: +# => "ENST00000341832" transcript is given in the "txfile.check3.txt" file +rm -f "./output/test.check3.WithTx_tcl.annotated.tsv" +$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check3.WithTx_tcl.annotated.tsv" -txFile "./input/txFile.check3.txt" -svtBEDcol 5 -tx "ENSEMBL" -genomeBuild GRCh37 +annotations=`$cut "./output/test.check3.WithTx_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` +#=> Now, the CDK11B gene is annotated with "ENST00000341832" +if [ `echo $annotations | grep -c "ENST00000341832"` != 0 ] +then + echo "Ok" +else + echo "error 1: the CDK11B gene is not annotated with the ENST00000341832 transcript" + exit 1 +fi + + + + +echo "ok - Finished" + + + + + + + diff --git a/tests/data/test_13_txFile/input/test.check1.bed b/tests/AnnotSV/test_13_txFile/input/test.check1.bed similarity index 76% rename from tests/data/test_13_txFile/input/test.check1.bed rename to tests/AnnotSV/test_13_txFile/input/test.check1.bed index b762f0d..345e27b 100755 --- a/tests/data/test_13_txFile/input/test.check1.bed +++ b/tests/AnnotSV/test_13_txFile/input/test.check1.bed @@ -1,4 +1,4 @@ #chrom start end score SV type 1 1490001 1530001 0222 DUP -1 1613810 1687739 0.25 DEL +1 1570602 1585465 DEL 1 94190001 95198431 0.001 DUP diff --git a/tests/data/test_13_txFile/input/test.check2.vcf b/tests/AnnotSV/test_13_txFile/input/test.check2.vcf similarity index 100% rename from tests/data/test_13_txFile/input/test.check2.vcf rename to tests/AnnotSV/test_13_txFile/input/test.check2.vcf diff --git a/tests/data/test_13_txFile/input/txFile.check1.txt b/tests/AnnotSV/test_13_txFile/input/txFile.check1.txt similarity index 100% rename from tests/data/test_13_txFile/input/txFile.check1.txt rename to tests/AnnotSV/test_13_txFile/input/txFile.check1.txt diff --git a/tests/data/test_13_txFile/input/txFile.check2.txt b/tests/AnnotSV/test_13_txFile/input/txFile.check2.txt similarity index 100% rename from tests/data/test_13_txFile/input/txFile.check2.txt rename to tests/AnnotSV/test_13_txFile/input/txFile.check2.txt diff --git a/tests/data/test_13_txFile/input/txFile.check3.txt b/tests/AnnotSV/test_13_txFile/input/txFile.check3.txt similarity index 100% rename from tests/data/test_13_txFile/input/txFile.check3.txt rename to tests/AnnotSV/test_13_txFile/input/txFile.check3.txt diff --git a/tests/data/test_14_candidateGenesFile/5 b/tests/AnnotSV/test_14_candidateGenesFile/5 similarity index 100% rename from tests/data/test_14_candidateGenesFile/5 rename to tests/AnnotSV/test_14_candidateGenesFile/5 diff --git a/tests/data/test_14_candidateGenesFile/command_Tcl.sh b/tests/AnnotSV/test_14_candidateGenesFile/command_Tcl.sh similarity index 100% rename from tests/data/test_14_candidateGenesFile/command_Tcl.sh rename to tests/AnnotSV/test_14_candidateGenesFile/command_Tcl.sh diff --git a/tests/data/test_14_candidateGenesFile/input/candidateGenesFile.txt b/tests/AnnotSV/test_14_candidateGenesFile/input/candidateGenesFile.txt similarity index 100% rename from tests/data/test_14_candidateGenesFile/input/candidateGenesFile.txt rename to tests/AnnotSV/test_14_candidateGenesFile/input/candidateGenesFile.txt diff --git a/tests/data/test_14_candidateGenesFile/input/test.bed b/tests/AnnotSV/test_14_candidateGenesFile/input/test.bed similarity index 100% rename from tests/data/test_14_candidateGenesFile/input/test.bed rename to tests/AnnotSV/test_14_candidateGenesFile/input/test.bed diff --git a/tests/data/test_15_EmptyVCF/command_Tcl.sh b/tests/AnnotSV/test_15_EmptyVCF/command_Tcl.sh similarity index 100% rename from tests/data/test_15_EmptyVCF/command_Tcl.sh rename to tests/AnnotSV/test_15_EmptyVCF/command_Tcl.sh diff --git a/tests/data/test_15_EmptyVCF/input/test.vcf b/tests/AnnotSV/test_15_EmptyVCF/input/test.vcf similarity index 100% rename from tests/data/test_15_EmptyVCF/input/test.vcf rename to tests/AnnotSV/test_15_EmptyVCF/input/test.vcf diff --git a/tests/data/test_16_reciprocalYes/command_Tcl.sh b/tests/AnnotSV/test_16_reciprocalYes/command_Tcl.sh similarity index 100% rename from tests/data/test_16_reciprocalYes/command_Tcl.sh rename to tests/AnnotSV/test_16_reciprocalYes/command_Tcl.sh diff --git a/tests/data/test_16_reciprocalYes/input/test.bed b/tests/AnnotSV/test_16_reciprocalYes/input/test.bed similarity index 100% rename from tests/data/test_16_reciprocalYes/input/test.bed rename to tests/AnnotSV/test_16_reciprocalYes/input/test.bed diff --git a/tests/data/test_16_reciprocalYes/input/test.vcf b/tests/AnnotSV/test_16_reciprocalYes/input/test.vcf similarity index 100% rename from tests/data/test_16_reciprocalYes/input/test.vcf rename to tests/AnnotSV/test_16_reciprocalYes/input/test.vcf diff --git a/tests/data/test_16_reciprocalYes/input/user_SVincludedInFt.bed b/tests/AnnotSV/test_16_reciprocalYes/input/user_SVincludedInFt.bed similarity index 100% rename from tests/data/test_16_reciprocalYes/input/user_SVincludedInFt.bed rename to tests/AnnotSV/test_16_reciprocalYes/input/user_SVincludedInFt.bed diff --git a/tests/data/test_17_rankFiltering/command_Tcl.sh b/tests/AnnotSV/test_17_rankFiltering/command_Tcl.sh similarity index 100% rename from tests/data/test_17_rankFiltering/command_Tcl.sh rename to tests/AnnotSV/test_17_rankFiltering/command_Tcl.sh diff --git a/tests/data/test_17_rankFiltering/input/test.bed b/tests/AnnotSV/test_17_rankFiltering/input/test.bed similarity index 100% rename from tests/data/test_17_rankFiltering/input/test.bed rename to tests/AnnotSV/test_17_rankFiltering/input/test.bed diff --git a/tests/data/test_18_VCFwithBrackets/command_Tcl.sh b/tests/AnnotSV/test_18_VCFwithBrackets/command_Tcl.sh similarity index 100% rename from tests/data/test_18_VCFwithBrackets/command_Tcl.sh rename to tests/AnnotSV/test_18_VCFwithBrackets/command_Tcl.sh diff --git a/tests/data/test_18_VCFwithBrackets/input/INPUT_gridss_germline_output.sv.vcf b/tests/AnnotSV/test_18_VCFwithBrackets/input/INPUT_gridss_germline_output.sv.vcf similarity index 100% rename from tests/data/test_18_VCFwithBrackets/input/INPUT_gridss_germline_output.sv.vcf rename to tests/AnnotSV/test_18_VCFwithBrackets/input/INPUT_gridss_germline_output.sv.vcf diff --git a/tests/data/test_18_VCFwithBrackets/input/triplesvmerge.vcf b/tests/AnnotSV/test_18_VCFwithBrackets/input/triplesvmerge.vcf similarity index 100% rename from tests/data/test_18_VCFwithBrackets/input/triplesvmerge.vcf rename to tests/AnnotSV/test_18_VCFwithBrackets/input/triplesvmerge.vcf diff --git a/tests/data/test_19_Mouse/command_Tcl.sh b/tests/AnnotSV/test_19_Mouse/command_Tcl.sh similarity index 100% rename from tests/data/test_19_Mouse/command_Tcl.sh rename to tests/AnnotSV/test_19_Mouse/command_Tcl.sh diff --git a/tests/data/test_19_Mouse/input/test.RE.bed b/tests/AnnotSV/test_19_Mouse/input/test.RE.bed similarity index 100% rename from tests/data/test_19_Mouse/input/test.RE.bed rename to tests/AnnotSV/test_19_Mouse/input/test.RE.bed diff --git a/tests/data/test_19_Mouse/input/test.bed b/tests/AnnotSV/test_19_Mouse/input/test.bed similarity index 100% rename from tests/data/test_19_Mouse/input/test.bed rename to tests/AnnotSV/test_19_Mouse/input/test.bed diff --git a/tests/data/test_20_MitochondrialSV/command_Tcl.sh b/tests/AnnotSV/test_20_MitochondrialSV/command_Tcl.sh similarity index 100% rename from tests/data/test_20_MitochondrialSV/command_Tcl.sh rename to tests/AnnotSV/test_20_MitochondrialSV/command_Tcl.sh diff --git a/tests/data/test_20_MitochondrialSV/input/test.bed b/tests/AnnotSV/test_20_MitochondrialSV/input/test.bed similarity index 100% rename from tests/data/test_20_MitochondrialSV/input/test.bed rename to tests/AnnotSV/test_20_MitochondrialSV/input/test.bed diff --git a/tests/data/test_21_ExternalGeneAnnotationFile/command_Tcl.sh b/tests/AnnotSV/test_21_ExternalGeneAnnotationFile/command_Tcl.sh similarity index 100% rename from tests/data/test_21_ExternalGeneAnnotationFile/command_Tcl.sh rename to tests/AnnotSV/test_21_ExternalGeneAnnotationFile/command_Tcl.sh diff --git a/tests/data/test_21_ExternalGeneAnnotationFile/input/configfile b/tests/AnnotSV/test_21_ExternalGeneAnnotationFile/input/configfile similarity index 100% rename from tests/data/test_21_ExternalGeneAnnotationFile/input/configfile rename to tests/AnnotSV/test_21_ExternalGeneAnnotationFile/input/configfile diff --git a/tests/data/test_21_ExternalGeneAnnotationFile/input/input.bed b/tests/AnnotSV/test_21_ExternalGeneAnnotationFile/input/input.bed similarity index 100% rename from tests/data/test_21_ExternalGeneAnnotationFile/input/input.bed rename to tests/AnnotSV/test_21_ExternalGeneAnnotationFile/input/input.bed diff --git a/tests/data/test_21_ExternalGeneAnnotationFile/input/user_annotations.tsv b/tests/AnnotSV/test_21_ExternalGeneAnnotationFile/input/user_annotations.tsv similarity index 100% rename from tests/data/test_21_ExternalGeneAnnotationFile/input/user_annotations.tsv rename to tests/AnnotSV/test_21_ExternalGeneAnnotationFile/input/user_annotations.tsv diff --git a/tests/data/test_22_knotAnnotSV_41SV/command_Tcl.sh b/tests/AnnotSV/test_22_knotAnnotSV_41SV/command_Tcl.sh similarity index 100% rename from tests/data/test_22_knotAnnotSV_41SV/command_Tcl.sh rename to tests/AnnotSV/test_22_knotAnnotSV_41SV/command_Tcl.sh diff --git a/tests/data/test_22_knotAnnotSV_41SV/input/config_AnnotSV.tmp.yaml b/tests/AnnotSV/test_22_knotAnnotSV_41SV/input/config_AnnotSV.tmp.yaml similarity index 100% rename from tests/data/test_22_knotAnnotSV_41SV/input/config_AnnotSV.tmp.yaml rename to tests/AnnotSV/test_22_knotAnnotSV_41SV/input/config_AnnotSV.tmp.yaml diff --git a/tests/data/test_22_knotAnnotSV_41SV/input/test.41_SV.bed b/tests/AnnotSV/test_22_knotAnnotSV_41SV/input/test.41_SV.bed similarity index 100% rename from tests/data/test_22_knotAnnotSV_41SV/input/test.41_SV.bed rename to tests/AnnotSV/test_22_knotAnnotSV_41SV/input/test.41_SV.bed diff --git a/tests/data/test_22_knotAnnotSV_41SV/input/test.7_SV.bed b/tests/AnnotSV/test_22_knotAnnotSV_41SV/input/test.7_SV.bed similarity index 100% rename from tests/data/test_22_knotAnnotSV_41SV/input/test.7_SV.bed rename to tests/AnnotSV/test_22_knotAnnotSV_41SV/input/test.7_SV.bed diff --git a/tests/data/test_23_Exomiser/command_Tcl.sh b/tests/AnnotSV/test_23_Exomiser/command_Tcl.sh similarity index 100% rename from tests/data/test_23_Exomiser/command_Tcl.sh rename to tests/AnnotSV/test_23_Exomiser/command_Tcl.sh diff --git a/tests/data/test_23_Exomiser/input/GRCh37-1SV.vcf b/tests/AnnotSV/test_23_Exomiser/input/GRCh37-1SV.vcf similarity index 100% rename from tests/data/test_23_Exomiser/input/GRCh37-1SV.vcf rename to tests/AnnotSV/test_23_Exomiser/input/GRCh37-1SV.vcf diff --git a/tests/data/test_23_Exomiser/input/GRCh37-multiSV.vcf b/tests/AnnotSV/test_23_Exomiser/input/GRCh37-multiSV.vcf similarity index 100% rename from tests/data/test_23_Exomiser/input/GRCh37-multiSV.vcf rename to tests/AnnotSV/test_23_Exomiser/input/GRCh37-multiSV.vcf diff --git a/tests/data/test_23_Exomiser/input/GRCh38-1SV.vcf b/tests/AnnotSV/test_23_Exomiser/input/GRCh38-1SV.vcf similarity index 100% rename from tests/data/test_23_Exomiser/input/GRCh38-1SV.vcf rename to tests/AnnotSV/test_23_Exomiser/input/GRCh38-1SV.vcf diff --git a/tests/data/test_23_Exomiser/input/GRCh38-multiSV.vcf b/tests/AnnotSV/test_23_Exomiser/input/GRCh38-multiSV.vcf similarity index 100% rename from tests/data/test_23_Exomiser/input/GRCh38-multiSV.vcf rename to tests/AnnotSV/test_23_Exomiser/input/GRCh38-multiSV.vcf diff --git a/tests/data/test_24_HtzCompound/command_Tcl.sh b/tests/AnnotSV/test_24_HtzCompound/command_Tcl.sh similarity index 100% rename from tests/data/test_24_HtzCompound/command_Tcl.sh rename to tests/AnnotSV/test_24_HtzCompound/command_Tcl.sh diff --git a/tests/data/test_24_HtzCompound/input/3samples.severalSV.vcf b/tests/AnnotSV/test_24_HtzCompound/input/3samples.severalSV.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/3samples.severalSV.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/3samples.severalSV.vcf diff --git a/tests/data/test_24_HtzCompound/input/3samples.snvindel.vcf b/tests/AnnotSV/test_24_HtzCompound/input/3samples.snvindel.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/3samples.snvindel.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/3samples.snvindel.vcf diff --git a/tests/data/test_24_HtzCompound/input/3samples.theSV.vcf b/tests/AnnotSV/test_24_HtzCompound/input/3samples.theSV.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/3samples.theSV.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/3samples.theSV.vcf diff --git a/tests/data/test_24_HtzCompound/input/3samples.theSnvindel.vcf b/tests/AnnotSV/test_24_HtzCompound/input/3samples.theSnvindel.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/3samples.theSnvindel.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/3samples.theSnvindel.vcf diff --git a/tests/data/test_24_HtzCompound/input/configfile b/tests/AnnotSV/test_24_HtzCompound/input/configfile similarity index 100% rename from tests/data/test_24_HtzCompound/input/configfile rename to tests/AnnotSV/test_24_HtzCompound/input/configfile diff --git a/tests/data/test_24_HtzCompound/input/test1.SV.bed b/tests/AnnotSV/test_24_HtzCompound/input/test1.SV.bed similarity index 100% rename from tests/data/test_24_HtzCompound/input/test1.SV.bed rename to tests/AnnotSV/test_24_HtzCompound/input/test1.SV.bed diff --git a/tests/data/test_24_HtzCompound/input/test1.SV.vcf b/tests/AnnotSV/test_24_HtzCompound/input/test1.SV.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/test1.SV.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/test1.SV.vcf diff --git a/tests/data/test_24_HtzCompound/input/test1.SV.withoutGT.vcf b/tests/AnnotSV/test_24_HtzCompound/input/test1.SV.withoutGT.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/test1.SV.withoutGT.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/test1.SV.withoutGT.vcf diff --git a/tests/data/test_24_HtzCompound/input/test1.snvindel.vcf b/tests/AnnotSV/test_24_HtzCompound/input/test1.snvindel.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/test1.snvindel.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/test1.snvindel.vcf diff --git a/tests/data/test_24_HtzCompound/input/test1.snvindel.withoutGT.vcf b/tests/AnnotSV/test_24_HtzCompound/input/test1.snvindel.withoutGT.vcf similarity index 100% rename from tests/data/test_24_HtzCompound/input/test1.snvindel.withoutGT.vcf rename to tests/AnnotSV/test_24_HtzCompound/input/test1.snvindel.withoutGT.vcf diff --git a/tests/data/test_25_big-ref-alt/command_Tcl.sh b/tests/AnnotSV/test_25_big-ref-alt/command_Tcl.sh similarity index 100% rename from tests/data/test_25_big-ref-alt/command_Tcl.sh rename to tests/AnnotSV/test_25_big-ref-alt/command_Tcl.sh diff --git a/tests/data/test_25_big-ref-alt/input/input_1-big-ref.vcf b/tests/AnnotSV/test_25_big-ref-alt/input/input_1-big-ref.vcf similarity index 100% rename from tests/data/test_25_big-ref-alt/input/input_1-big-ref.vcf rename to tests/AnnotSV/test_25_big-ref-alt/input/input_1-big-ref.vcf diff --git a/tests/data/test_26_HtzHomCounts_deletionFiltering/command_Tcl.sh b/tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/command_Tcl.sh similarity index 100% rename from tests/data/test_26_HtzHomCounts_deletionFiltering/command_Tcl.sh rename to tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/command_Tcl.sh diff --git a/tests/data/test_26_HtzHomCounts_deletionFiltering/input/3samples.SV.vcf b/tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/3samples.SV.vcf similarity index 100% rename from tests/data/test_26_HtzHomCounts_deletionFiltering/input/3samples.SV.vcf rename to tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/3samples.SV.vcf diff --git a/tests/data/test_26_HtzHomCounts_deletionFiltering/input/3samples.extract-HG00096.snvindel.vcf b/tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/3samples.extract-HG00096.snvindel.vcf similarity index 100% rename from tests/data/test_26_HtzHomCounts_deletionFiltering/input/3samples.extract-HG00096.snvindel.vcf rename to tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/3samples.extract-HG00096.snvindel.vcf diff --git a/tests/data/test_26_HtzHomCounts_deletionFiltering/input/SV.bed b/tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/SV.bed similarity index 100% rename from tests/data/test_26_HtzHomCounts_deletionFiltering/input/SV.bed rename to tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/SV.bed diff --git a/tests/data/test_26_HtzHomCounts_deletionFiltering/input/extract-HG00096.vcf b/tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/extract-HG00096.vcf similarity index 100% rename from tests/data/test_26_HtzHomCounts_deletionFiltering/input/extract-HG00096.vcf rename to tests/AnnotSV/test_26_HtzHomCounts_deletionFiltering/input/extract-HG00096.vcf diff --git a/tests/data/test_27_Samples_ID/command_Tcl.sh b/tests/AnnotSV/test_27_Samples_ID/command_Tcl.sh similarity index 100% rename from tests/data/test_27_Samples_ID/command_Tcl.sh rename to tests/AnnotSV/test_27_Samples_ID/command_Tcl.sh diff --git a/tests/data/test_27_Samples_ID/input/test-withoutHeader.bed b/tests/AnnotSV/test_27_Samples_ID/input/test-withoutHeader.bed similarity index 100% rename from tests/data/test_27_Samples_ID/input/test-withoutHeader.bed rename to tests/AnnotSV/test_27_Samples_ID/input/test-withoutHeader.bed diff --git a/tests/data/test_27_Samples_ID/input/test.bed b/tests/AnnotSV/test_27_Samples_ID/input/test.bed similarity index 100% rename from tests/data/test_27_Samples_ID/input/test.bed rename to tests/AnnotSV/test_27_Samples_ID/input/test.bed diff --git a/tests/data/test_27_Samples_ID/input/test.vcf b/tests/AnnotSV/test_27_Samples_ID/input/test.vcf similarity index 100% rename from tests/data/test_27_Samples_ID/input/test.vcf rename to tests/AnnotSV/test_27_Samples_ID/input/test.vcf diff --git a/tests/data/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/command_Tcl.sh b/tests/AnnotSV/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/command_Tcl.sh similarity index 100% rename from tests/data/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/command_Tcl.sh rename to tests/AnnotSV/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/command_Tcl.sh diff --git a/tests/data/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/input/test.bed b/tests/AnnotSV/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/input/test.bed similarity index 100% rename from tests/data/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/input/test.bed rename to tests/AnnotSV/test_28_SVsharingTheSameCoordinatesButWithDifferentSVTYPE/input/test.bed diff --git a/tests/data/test_29_distNearestSS/command_Tcl.sh b/tests/AnnotSV/test_29_distNearestSS/command_Tcl.sh similarity index 80% rename from tests/data/test_29_distNearestSS/command_Tcl.sh rename to tests/AnnotSV/test_29_distNearestSS/command_Tcl.sh index 9634c5b..c91bfeb 100755 --- a/tests/data/test_29_distNearestSS/command_Tcl.sh +++ b/tests/AnnotSV/test_29_distNearestSS/command_Tcl.sh @@ -5,6 +5,13 @@ set -eo pipefail cut="$ANNOTSV/tests/data/scripts/cutWithColumnNames.tcl" +# GRCh37, NM_001037668: +####################### +# NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*): +# - NM_001037668.1 - chr8:7669242-7673238 +# UCSC annotations of RefSeq RNAs (NM_* and NR_*): +# - NM_001037668 - chr8:7669242-7673238 +# - NM_001037668 - chr8:7353368-7366833 ############################################################################################# @@ -14,32 +21,31 @@ cut="$ANNOTSV/tests/data/scripts/cutWithColumnNames.tcl" # Each SV has 2 breakpoints: BND left and BND right -# BND left in the last exon of a gene + BND right outside the gene -################################################################## +# (Strand -) BND left outside the gene + BND right in the last exon of a gene +############################################################################# -# Input SV: chr8:7366741-7368724 +# Input SV: chr8:7669129-7669261 # gr "NM_001037668" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed -# 8 7353367 7366833 + DEFB107A NM_001037668 7353455 7366745 7353367,7366602, 7353525,7366833, -# => NM_001037668 : strand = + +# 8 7669241 7673238 - DEFB107A NM_001037668 7669329 7673150 7669241,7673080, 7669472,7673238, +# => NM_001037668 : strand = - -# The "SVleft" (7366741) is located in the last exon of the transcript NM_001037668 (7366602-7366833) -# The BND is 139 bp after the start of the last exon (3') : 7366602 + 139 = 7366741 -# and 92 bp before the end of the exon (last exon => the end of the exon does not correspond to a splice site) +# The "SVright" (7669261) is located in the last exon of the transcript NM_001037668 (7669241-7669472) +# The BND is 20 bp after the end of the last exon (3') : 7669261 - 7669241 = 20 +# and 211 bp (7669472 - 7669261) bp before the start of the exon (last exon => the end of the exon does not correspond to a splice site) # => we can only calculate the distance in relation to the site in 3' (acceptor) -# => distNearestSS = 139 in 3' +# => distNearestSS = 211 in 3' rm -f "./output/test1_tcl.annotated.tsv" $ANNOTSV/bin/AnnotSV -SVinputFile "./input/test1.vcf" -outputFile "./output/test1_tcl.annotated.tsv" -genomeBuild GRCh37 # $cut "./output/test1_tcl.annotated.tsv" "AnnotSV_ID;Annotation_mode;Gene_name;Tx;Location;Location2;Dist_nearest_SS;Nearest_SS_type" # AnnotSV_ID Annotation_mode Gene_name Tx Location Location2 Dist_nearest_SS Nearest_SS_type -# 8_7366741_7368724_DEL_1 full DEFB107A;DEFB107B -# 8_7366741_7368724_DEL_1 split DEFB107A NM_001037668 exon2-txEnd CDS-3'UTR 138 3' -# 8_7366741_7368724_DEL_1 split DEFB107B NM_001040705 exon2-txEnd CDS-3'UTR 138 3' +# 8_7669129_7669261_DEL_1 full DEFB107A +# 8_7669129_7669261_DEL_1 split DEFB107A NM_001037668 exon2-txEnd 3'UTR 211 3' annotations=`$cut "./output/test1_tcl.annotated.tsv" "Tx;Dist_nearest_SS;Nearest_SS_type" | grep "NM_001037668"` -if [ `echo $annotations | grep -c "NM_001037668 138 3'"` == 1 ] +if [ `echo $annotations | grep -c "NM_001037668 211 3'"` == 1 ] then echo "Ok" else @@ -52,7 +58,7 @@ fi # We must not have a value for distNearestSS -# grep "bbs10" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# gr "bbs10" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed # 12 76738253 76742195 - BBS10 NM_024685 76739592 76742138 76738253,76741941, 76741567,76742195, # => strand = - @@ -81,7 +87,7 @@ fi # Input SV: 12:76738280-76741600 -# grep "bbs10" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# gr "bbs10" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed # 12 76738253 76742195 - BBS10 NM_024685 76739592 76742138 76738253,76741941, 76741567,76742195, rm -f "./output/test3_tcl.annotated.tsv" $ANNOTSV/bin/AnnotSV -SVinputFile "./input/test3.bed" -outputFile "./output/test3_tcl.annotated.tsv" -svtBEDcol 4 -genomeBuild GRCh37 @@ -107,7 +113,7 @@ fi # Input SV: 2:170343580-170349500 -# grep "bbs5" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# gr "bbs5" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed # 2 170336003 170363165 + BBS5 NM_152384 170336063 170361092 170336003,170338760,170343578,170344315,170344496,170349383,170350250,170354136,170355995,170359604,170360812,170360990, 170336122,170338843,170343644,170344365,170344624,170349519,170350346,170354199,170356130,170359688,170360836,170363165, rm -f "./output/test4_tcl.annotated.tsv" $ANNOTSV/bin/AnnotSV -SVinputFile "./input/test4.bed" -outputFile "./output/test4_tcl.annotated.tsv" -svtBEDcol 4 -genomeBuild GRCh37 @@ -132,7 +138,7 @@ fi # Input SV : 2:170343650-170344315 -# grep "bbs5" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed +# gr "bbs5" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed # 2 170336003 170363165 + BBS5 NM_152384 170336063 170361092 170336003,170338760,170343578,170344315,170344496,170349383,170350250,170354136,170355995,170359604,170360812,170360990, 170336122,170338843,170343644,170344365,170344624,170349519,170350346,170354199,170356130,170359688,170360836,170363165, rm -f "./output/test5_tcl.annotated.tsv" $ANNOTSV/bin/AnnotSV -SVinputFile "./input/test5.bed" -outputFile "./output/test5_tcl.annotated.tsv" -svtBEDcol 4 -genomeBuild GRCh37 @@ -155,19 +161,20 @@ fi # SV with one breakpoint that matches exactly the end of one exon, and the other breakpoint that matches exactly the start of another exon ########################################################################################################################################## -# Input SV: 11:7716903-7717219 DEL +# Input SV: 11:7716419-7716800 DEL # grep "NM_198185" $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed -# 11 7711153 7728024 - OVCH2 NM_198185 7711185 7727941 7711153,7712499,7713132,7716288,7716800,7717219,7718011,7718255,7720296,7721842,7722870,7723262,7723703,7725244,7726111,7727853, 7711244,7712631,7713226,7716419,7716903,7717257,7718136,7718346,7720320,7722032,7723022,7723358,7723876,7725336,7726221,7728024, +# 11 7710667 7728024 - OVCH2 NM_198185 7711185 7727941 7710667,7711154,7712499,7713132,7716288,7716800,7717231,7718011,7718255,7720296,7721842,7722870,7723262,7723703,7725244,7726111,7727853, 7710833,7711244,7712631,7713226,7716419,7716915,7717257,7718136,7718346,7720320,7722032,7723022,7723358,7723876,7725336,7726221,7728024, + rm -f "./output/test6_tcl.annotated.tsv" $ANNOTSV/bin/AnnotSV -SVinputFile "./input/test6.bed" -outputFile "./output/test6_tcl.annotated.tsv" -svtBEDcol 4 -genomeBuild GRCh37 # $cut "./output/test6_tcl.annotated.tsv" "AnnotSV_ID;Annotation_mode;Gene_name;Tx;Location;Location2;Dist_nearest_SS;Nearest_SS_type" # AnnotSV_ID Annotation_mode Gene_name Tx Location Location2 Dist_nearest_SS Nearest_SS_type # 11_7716903_7717219_DEL_1 full OVCH2 -# 11_7716903_7717219_DEL_1 split OVCH2 NM_198185 intron11-intron11 CDS 0 3' +# 11_7716903_7717219_DEL_1 split OVCH2 NM_198185 intron12-intron12 CDS 0 3' annotations=`$cut "./output/test6_tcl.annotated.tsv" "Tx;Location;Location2;Dist_nearest_SS;Nearest_SS_type" | grep "NM_198185"` -if [ `echo $annotations | grep -c "NM_198185 intron11-intron11 CDS 0 3'"` == 1 ] +if [ `echo $annotations | grep -c "NM_198185 intron12-intron12 CDS 0 3'"` == 1 ] then echo "Ok" else diff --git a/tests/AnnotSV/test_29_distNearestSS/input/test1.vcf b/tests/AnnotSV/test_29_distNearestSS/input/test1.vcf new file mode 100755 index 0000000..26b8a91 --- /dev/null +++ b/tests/AnnotSV/test_29_distNearestSS/input/test1.vcf @@ -0,0 +1,2 @@ +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT ALBS +chr8 7669129 . N 12 cnvLength SVTYPE=CNV;END=7669261 GT:SM:CN:BC:PE 0/1:0.604884:1:1:2,2 diff --git a/tests/data/test_29_distNearestSS/input/test2.bed b/tests/AnnotSV/test_29_distNearestSS/input/test2.bed similarity index 100% rename from tests/data/test_29_distNearestSS/input/test2.bed rename to tests/AnnotSV/test_29_distNearestSS/input/test2.bed diff --git a/tests/data/test_29_distNearestSS/input/test3.bed b/tests/AnnotSV/test_29_distNearestSS/input/test3.bed similarity index 100% rename from tests/data/test_29_distNearestSS/input/test3.bed rename to tests/AnnotSV/test_29_distNearestSS/input/test3.bed diff --git a/tests/data/test_29_distNearestSS/input/test4.bed b/tests/AnnotSV/test_29_distNearestSS/input/test4.bed similarity index 100% rename from tests/data/test_29_distNearestSS/input/test4.bed rename to tests/AnnotSV/test_29_distNearestSS/input/test4.bed diff --git a/tests/data/test_29_distNearestSS/input/test5.bed b/tests/AnnotSV/test_29_distNearestSS/input/test5.bed similarity index 100% rename from tests/data/test_29_distNearestSS/input/test5.bed rename to tests/AnnotSV/test_29_distNearestSS/input/test5.bed diff --git a/tests/AnnotSV/test_29_distNearestSS/input/test6.bed b/tests/AnnotSV/test_29_distNearestSS/input/test6.bed new file mode 100755 index 0000000..4097221 --- /dev/null +++ b/tests/AnnotSV/test_29_distNearestSS/input/test6.bed @@ -0,0 +1 @@ +11 7716419 7716800 DEL diff --git a/tests/data/test_30_Ranking/command_Tcl.sh b/tests/AnnotSV/test_30_Ranking/command_Tcl.sh similarity index 100% rename from tests/data/test_30_Ranking/command_Tcl.sh rename to tests/AnnotSV/test_30_Ranking/command_Tcl.sh diff --git a/tests/data/test_30_Ranking/input/test.bed b/tests/AnnotSV/test_30_Ranking/input/test.bed similarity index 100% rename from tests/data/test_30_Ranking/input/test.bed rename to tests/AnnotSV/test_30_Ranking/input/test.bed diff --git a/tests/data/test_31_Cytoband/command_Tcl.sh b/tests/AnnotSV/test_31_Cytoband/command_Tcl.sh similarity index 93% rename from tests/data/test_31_Cytoband/command_Tcl.sh rename to tests/AnnotSV/test_31_Cytoband/command_Tcl.sh index 38ebea3..78d3a10 100755 --- a/tests/data/test_31_Cytoband/command_Tcl.sh +++ b/tests/AnnotSV/test_31_Cytoband/command_Tcl.sh @@ -16,6 +16,7 @@ cut="$ANNOTSV/tests/data/scripts/cutWithColumnNames.tcl" # chr17 1 18960000 DEL # GRCh37 cytoband file: +# grep "^17" $ANNOTSV/share/AnnotSV/Annotations_Human/AnyOverlap/CytoBand/GRCh37/cytoBand_GRCh37.formatted.sorted.bed | head -5 # chr17 0 3300000 p13.3 gneg # chr17 3300000 6500000 p13.2 gpos50 # chr17 6500000 10700000 p13.1 gneg diff --git a/tests/data/test_31_Cytoband/input/test.bed b/tests/AnnotSV/test_31_Cytoband/input/test.bed similarity index 100% rename from tests/data/test_31_Cytoband/input/test.bed rename to tests/AnnotSV/test_31_Cytoband/input/test.bed diff --git a/tests/data/test_32_metrics/command_Tcl.sh b/tests/AnnotSV/test_32_metrics/command_Tcl.sh similarity index 86% rename from tests/data/test_32_metrics/command_Tcl.sh rename to tests/AnnotSV/test_32_metrics/command_Tcl.sh index 7dff1cc..74a2182 100755 --- a/tests/data/test_32_metrics/command_Tcl.sh +++ b/tests/AnnotSV/test_32_metrics/command_Tcl.sh @@ -32,10 +32,12 @@ $ANNOTSV/bin/AnnotSV -SVinputFile "./input/input.bed" -SVinputInfo 1 -outputFile # $cut "./output/output.us_tcl.annotated.tsv" "B_gain_AFmax;B_loss_AFmax;B_ins_AFmax;B_inv_AFmax;GC_content_left;DDD_HI_percent;ExAC_synZ;GnomAD_pLI;ExAC_pLI;AnnotSV_ranking_score;AnnotSV_ranking_criteria;ACMG_class" # B_gain_AFmax B_loss_AFmax B_ins_AFmax B_inv_AFmax GC_content_left DDD_HI_percent ExAC_synZ GnomAD_pLI ExAC_pLI AnnotSV_ranking_score AnnotSV_ranking_criteria ACMG_class -# 0.0927 0.340 0.27 -2.65362022636097 1.0000e+00 1.0000e+00 0.9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (DMD, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -# 0.0927 0.27 -2.65362022636097 1.0000e+00 1.0000e+00 full=4 -# 0.0237 0.435 4.17 0.0512652381981393 9.9443e-01 9.9912e-01 0.15 1A (cf Gene_count, RE_gene, +0.00);2H (DIAPH2, +0.15);3A (1 gene, +0.00);5F (+0.00) 3 -# 0.0237 4.17 0.0512652381981393 9.9443e-01 9.9912e-01 full=3 +# 0.01 0.0927 0.1667 0.340 0.27 -2.65362022636097 1.0000e+00 1.0000e+00 0.9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (DMD, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +# 0.01 0.0927 0.1667 0.27 -2.65362022636097 1.0000e+00 1.0000e+00 full=4 +# 0.0237 0.0845 0.435 4.17 0.0512652381981393 9.9443e-01 9.9912e-01 0.15 1A (cf Gene_count, RE_gene, +0.00);2H (DIAPH2, +0.15);3A (1 gene, +0.00);5F (+0.00) 3 +# 0.0237 0.0845 4.17 0.0512652381981393 9.9443e-01 9.9912e-01 full=3 + + for v in `$cut "./output/output.us_tcl.annotated.tsv" "ACMG_class" | sort -u` do if ! exists_in_list "3 4 ACMG_class full=3 full=4" " " "$v" @@ -48,7 +50,7 @@ done annotations=`$cut "./output/output.us_tcl.annotated.tsv" "B_gain_AFmax;B_loss_AFmax;B_ins_AFmax;B_inv_AFmax;GC_content_left;DDD_HI_percent;ExAC_synZ;GnomAD_pLI;ExAC_pLI;AnnotSV_ranking_score;AnnotSV_ranking_criteria;ACMG_class" | grep -v "full="` -if [ `echo $annotations | tr " " "\n" | grep -c "\\."` == 22 ] +if [ `echo $annotations | tr " " "\n" | grep -c "\\."` == 25 ] then echo "Ok" else @@ -65,10 +67,11 @@ $ANNOTSV/bin/AnnotSV -SVinputFile "./input/input.bed" -SVinputInfo 1 -metrics fr # $cut "./output/output.fr_tcl.annotated.tsv" "B_gain_AFmax;B_loss_AFmax;B_ins_AFmax;B_inv_AFmax;GC_content_left;DDD_HI_percent;ExAC_synZ;GnomAD_pLI;ExAC_pLI;AnnotSV_ranking_score;AnnotSV_ranking_criteria;ACMG_class" # B_gain_AFmax B_loss_AFmax B_ins_AFmax B_inv_AFmax GC_content_left DDD_HI_percent ExAC_synZ GnomAD_pLI ExAC_pLI AnnotSV_ranking_score AnnotSV_ranking_criteria ACMG_class -# 0,0927 0,340 0,27 -2,65362022636097 1,0 1,0 0,9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (DMD, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -# 0,0927 0,27 -2,65362022636097 1,0 1,0 full=4 -# 0,0237 0,435 4,17 0,0512652381981393 0,99443 0,99912 0,15 1A (cf Gene_count, RE_gene, +0.00);2H (DIAPH2, +0.15);3A (1 gene, +0.00);5F (+0.00) 3 -# 0,0237 4,17 0,0512652381981393 0,99443 0,99912 full=3 +# 0,01 0,0927 0,1667 0,340 0,27 -2,65362022636097 1,0 1,0 0,9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (DMD, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 +# 0,01 0,0927 0,1667 0,27 -2,65362022636097 1,0 1,0 full=4 +# 0,0237 0,0845 0,435 4,17 0,0512652381981393 0,99443 0,99912 0,15 1A (cf Gene_count, RE_gene, +0.00);2H (DIAPH2, +0.15);3A (1 gene, +0.00);5F (+0.00) 3 +# 0,0237 0,0845 4,17 0,0512652381981393 0,99443 0,99912 full=3 + for v in `$cut "./output/output.fr_tcl.annotated.tsv" "ACMG_class" | sort -u` do @@ -82,7 +85,7 @@ done annotations=`$cut "./output/output.fr_tcl.annotated.tsv" "B_gain_AFmax;B_loss_AFmax;B_ins_AFmax;B_inv_AFmax;GC_content_left;DDD_HI_percent;ExAC_synZ;GnomAD_pLI;ExAC_pLI;AnnotSV_ranking_score;AnnotSV_ranking_criteria;ACMG_class" | grep -v "full="` -if [ `echo $annotations | tr " " "\n" | grep -c ","` == 22 ] +if [ `echo $annotations | tr " " "\n" | grep -c ","` == 25 ] then echo "Ok" else diff --git a/tests/data/test_32_metrics/input/input.bed b/tests/AnnotSV/test_32_metrics/input/input.bed similarity index 100% rename from tests/data/test_32_metrics/input/input.bed rename to tests/AnnotSV/test_32_metrics/input/input.bed diff --git a/tests/data/test_33_webSiteExample/command_Tcl.sh b/tests/AnnotSV/test_33_webSiteExample/command_Tcl.sh similarity index 100% rename from tests/data/test_33_webSiteExample/command_Tcl.sh rename to tests/AnnotSV/test_33_webSiteExample/command_Tcl.sh diff --git a/tests/data/test_33_webSiteExample/input/test.bed b/tests/AnnotSV/test_33_webSiteExample/input/test.bed similarity index 100% rename from tests/data/test_33_webSiteExample/input/test.bed rename to tests/AnnotSV/test_33_webSiteExample/input/test.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/README b/tests/AnnotSV/test_34_bracketedToAngularNotations/README similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/README rename to tests/AnnotSV/test_34_bracketedToAngularNotations/README diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/README b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/README similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/README rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/README diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test_difficult.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test_difficult.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test_difficult.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Difficult/test_difficult.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/command_20_square-bracketed-inv2.annotated.tsv b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/command_20_square-bracketed-inv2.annotated.tsv similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/command_20_square-bracketed-inv2.annotated.tsv rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/command_20_square-bracketed-inv2.annotated.tsv diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.annotated.tsv b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.annotated.tsv similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.annotated.tsv rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.annotated.tsv diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.annotated.tsv b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.annotated.tsv similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.annotated.tsv rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/Outputs/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.annotated.tsv diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/README b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/README similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/README rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/README diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/output.csv b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/output.csv similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/output.csv rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/output.csv diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/severalSVTYPE-square-bracketed.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/severalSVTYPE-square-bracketed.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/severalSVTYPE-square-bracketed.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/severalSVTYPE-square-bracketed.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/test_paired.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/test_paired.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/test_paired.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/test_paired.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.output.csv b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.output.csv similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.output.csv rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.output.csv diff --git a/tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/Rodrigo_tests_ignore/tra.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/command_Tcl.sh b/tests/AnnotSV/test_34_bracketedToAngularNotations/command_Tcl.sh similarity index 99% rename from tests/data/test_34_bracketedToAngularNotations/command_Tcl.sh rename to tests/AnnotSV/test_34_bracketedToAngularNotations/command_Tcl.sh index 784daa7..7132363 100755 --- a/tests/data/test_34_bracketedToAngularNotations/command_Tcl.sh +++ b/tests/AnnotSV/test_34_bracketedToAngularNotations/command_Tcl.sh @@ -230,7 +230,7 @@ echo "Command_5 (angle) OK" # WARNING: No filtering on the SV min size (min > 50 bp) from a BED input file BEDresult=`$cut "./output/command_5_BED-empty_del.annotated.tsv" "AnnotSV_ID;SV_chrom;SV_start;SV_end;SV_length;SV_type;ACMG_class" | tail -1 | awk 'BEGIN{ORS=" "; OFS=" "} { print $1, $2, $3, $4, $5, $6, $7}'` -if [ "$BEDresult" != "15_53040041_53040042_DEL_1 15 53040041 53040042 -1 DEL 3 " ] +if [ "$BEDresult" != "15_53040041_53040042_DEL_1 15 53040041 53040042 -1 DEL full=1 " ] then echo "error 1: Error with command_5 (BED bad values)" exit 1 diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_partial_pass.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_partial_pass.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_partial_pass.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-del_partial_pass.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-dup.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-dup.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-dup.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-dup.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-empty_del.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-empty_del.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-empty_del.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-empty_del.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-ins_by_gridss.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-ins_by_gridss.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-ins_by_gridss.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-ins_by_gridss.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv2.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv2.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv2.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-inv2.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra2.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra2.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra2.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-angle-bracketed-tra2.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-del_1.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-del_1.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-del_1.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-del_1.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-del_partial_pass.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-del_partial_pass.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-del_partial_pass.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-del_partial_pass.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-dup.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-dup.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-dup.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-dup.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-empty_del.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-empty_del.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-empty_del.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-empty_del.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-ins_by_gridss.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-ins_by_gridss.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-ins_by_gridss.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-ins_by_gridss.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-inv1.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-inv1.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-inv1.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-inv1.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_partial_pass.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_partial_pass.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_partial_pass.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_partial_pass.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_unordered.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_unordered.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_unordered.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-del_unordered.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-dup.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-dup.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-dup.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-dup.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-empty_del.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-empty_del.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-empty_del.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-empty_del.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-ins_by_gridss.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-ins_by_gridss.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-ins_by_gridss.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-ins_by_gridss.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv2.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv2.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv2.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv2.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv3.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv3.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv3.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-inv3.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra2.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra2.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra2.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-square-bracketed-tra2.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input-tra1.bed b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-tra1.bed similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input-tra1.bed rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input-tra1.bed diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_partial_pass.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_partial_pass.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_partial_pass.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_partial_pass.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_unordered.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_unordered.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_unordered.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-del_unordered.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-dup.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-dup.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-dup.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-dup.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-empty_del.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-empty_del.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-empty_del.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-empty_del.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-ins_by_gridss.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-ins_by_gridss.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-ins_by_gridss.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-ins_by_gridss.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv2.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv2.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv2.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-inv2.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_1.vcf diff --git a/tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.vcf b/tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.vcf similarity index 100% rename from tests/data/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.vcf rename to tests/AnnotSV/test_34_bracketedToAngularNotations/input/input_OnlyTheReciprocalBND_square-bracketed-tra1_2.vcf diff --git a/tests/data/test_35_phenogenius/command_Tcl.sh b/tests/AnnotSV/test_35_phenogenius/command_Tcl.sh similarity index 100% rename from tests/data/test_35_phenogenius/command_Tcl.sh rename to tests/AnnotSV/test_35_phenogenius/command_Tcl.sh diff --git a/tests/data/test_35_phenogenius/input/PKD1.bed b/tests/AnnotSV/test_35_phenogenius/input/PKD1.bed similarity index 100% rename from tests/data/test_35_phenogenius/input/PKD1.bed rename to tests/AnnotSV/test_35_phenogenius/input/PKD1.bed diff --git a/tests/data/test_35_phenogenius/input/test.bed b/tests/AnnotSV/test_35_phenogenius/input/test.bed similarity index 100% rename from tests/data/test_35_phenogenius/input/test.bed rename to tests/AnnotSV/test_35_phenogenius/input/test.bed diff --git a/tests/data/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv b/tests/data/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv deleted file mode 100755 index c657beb..0000000 --- a/tests/data/test_03_CDSandTxCoverage/input/test_tcl.annotated.tsv.truth.sauv +++ /dev/null @@ -1,19 +0,0 @@ -AnnotSV_ID SV_chrom SV_start SV_end SV_length SV_type Annotation_mode CytoBand Gene_name Gene_count Tx Tx_start Tx_end Overlapped_tx_length Overlapped_CDS_length Overlapped_CDS_percent Frameshift Exon_count Location Location2 Dist_nearest_SS Nearest_SS_type Intersect_start Intersect_end RE_gene P_gain_phen P_gain_hpo P_gain_source P_gain_coord P_loss_phen P_loss_hpo P_loss_source P_loss_coord P_ins_phen P_ins_hpo P_ins_source P_ins_coord po_P_gain_phen po_P_gain_hpo po_P_gain_source po_P_gain_coord po_P_gain_percent po_P_loss_phen po_P_loss_hpo po_P_loss_source po_P_loss_coord po_P_loss_percent P_snvindel_nb P_snvindel_phen B_gain_source B_gain_coord B_gain_AFmax B_loss_source B_loss_coord B_loss_AFmax B_ins_source B_ins_coord B_ins_AFmax B_inv_source B_inv_coord B_inv_AFmax po_B_gain_allG_source po_B_gain_allG_coord po_B_gain_someG_source po_B_gain_someG_coord po_B_loss_allG_source po_B_loss_allG_coord po_B_loss_someG_source po_B_loss_someG_coord TAD_coordinate ENCODE_experiment Cosmic_ID Cosmic_mut_typ GC_content_left GC_content_right Repeat_coord_left Repeat_type_left Repeat_coord_right Repeat_type_right Gap_left Gap_right SegDup_left SegDup_right ENCODE_blacklist_left ENCODE_blacklist_characteristics_left ENCODE_blacklist_right ENCODE_blacklist_characteristics_right ACMG HI TS DDD_HI_percent ExAC_delZ ExAC_dupZ ExAC_cnvZ ExAC_synZ ExAC_misZ GenCC_disease GenCC_moi GenCC_classification GenCC_pmid OMIM_ID OMIM_phenotype OMIM_inheritance OMIM_morbid OMIM_morbid_candidate LOEUF_bin GnomAD_pLI ExAC_pLI AnnotSV_ranking_score AnnotSV_ranking_criteria ACMG_class -1_161511000_161514600_DEL_1 1 161511000 161514600 -3600 DEL full q23.3 FCGR3A 1 ATF6 (morbid/RE=EA_enhancer);MPZ (morbid/RE=EA_enhancer);SDHC (HI=3/morbid/RE=EA_enhancer) dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00;0.01;0.02 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.02;0.04;0.05;0.06;0.14;33.98 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;DDD:3093 1:161484999-161522125;1:161488421-161634845 0.435 0.440 1:161510915-161511163 L2c 1:161479597-161518642 1:161479597-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2D-4 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -1_161511000_161514600_DEL_1 1 161511000 161514600 -3600 DEL split q23.3 FCGR3A NM_000569 161511549 161519608 3051 298 38 yes 5 exon4-txEnd CDS-3'UTR 110 5' 161511549 161514600 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 -1_161512500_161518300_DEL_1 1 161512500 161518300 -5800 DEL full q23.3 FCGR3A 1 ATF6 (morbid/RE=EA_enhancer);MPZ (morbid/RE=EA_enhancer);SDHC (HI=3/morbid/RE=EA_enhancer) dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00;0.01;0.02;0.03 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.01;0.03;0.04;0.06;0.08;0.10;0.23;64.60 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;DDD:3093 1:161484999-161522125;1:161488421-161634845 0.360 0.545 1:161479597-161518642 1:161479597-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2D-4 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -1_161512500_161518300_DEL_1 1 161512500 161518300 -5800 DEL split q23.3 FCGR3A NM_000569 161511549 161519608 5800 536 70 yes 5 exon3-exon5 CDS-3'UTR 90 5' 161512500 161518300 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 -1_161518600_161519950_DEL_1 1 161518600 161519950 -1350 DEL full q23.3 FCGR3A 1 dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00;0.01 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.01;0.02;0.05;15.04 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;1000g;esv3587731;DDD:3093 1:161484999-161522125;1:161519612-161593482;1:161519612-161593482;1:161488421-161634845 0.535 0.545 1:161479597-161518642;1:161518643-161565122 1:161518643-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -1_161518600_161519950_DEL_1 1 161518600 161519950 -1350 DEL split q23.3 FCGR3A NM_001127592 161511549 161519893 1293 376 34 yes 5 txStart-intron2 5'UTR-CDS 135 3' 161518600 161519893 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 -1_161518810_161519500_DEL_1 1 161518810 161519500 -690 DEL full q23.3 FCGR3A 1 dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.01;0.03;7.69 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;DDD:3093 1:161484999-161522125;1:161488421-161634845 0.450 0.535 1:161518643-161565122 1:161518643-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2E-1 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -1_161518810_161519500_DEL_1 1 161518810 161519500 -690 DEL split q23.3 FCGR3A NM_000569 161511549 161519608 690 25 3 yes 5 exon1-exon2 CDS 10 5' 161518810 161519500 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 -1_161518810_161519850_DEL_1 1 161518810 161519850 -1040 DEL full q23.3 FCGR3A 1 dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00;0.01 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.01;0.02;0.04;11.58 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;1000g;esv3587731;DDD:3093 1:161484999-161522125;1:161519612-161593482;1:161519612-161593482;1:161488421-161634845 0.450 0.570 1:161518643-161565122 1:161518643-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 0.9 1A (cf Gene_count, RE_gene, +0.00);2C-1 (FCGR3A, +0.90);3A (1 gene, +0.00);5F (+0.00) 4 -1_161518810_161519850_DEL_1 1 161518810 161519850 -1040 DEL split q23.3 FCGR3A NM_001127592 161511549 161519893 1040 366 33 no 5 exon1-exon2 5'UTR-CDS 10 5' 161518810 161519850 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=4 -1_161511000_161512900_DEL_1 1 161511000 161512900 -1900 DEL full q23.3 FCGR3A 1 dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00;0.01 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.01;0.02;0.03;0.07;15.05 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;DDD:3093 1:161484999-161522125;1:161488421-161634845 0.435 0.425 1:161510915-161511163 L2c 1:161479597-161518642 1:161479597-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 0.45 1A (cf Gene_count, RE_gene, +0.00);2D-3 (FCGR3A, +0.45);3A (1 gene, +0.00);5F (+0.00) 3 -1_161511000_161512900_DEL_1 1 161511000 161512900 -1900 DEL split q23.3 FCGR3A NM_000569 161511549 161519608 1351 99 12 no 5 exon5-txEnd CDS-3'UTR 89 3' 161511549 161512900 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=3 -1_161511000_161511600_DEL_1 1 161511000 161511600 -600 DEL full q23.3 FCGR3A 1 dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.01;0.02;0.57 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;DDD:3093 1:161484999-161522125;1:161488421-161634845 0.435 0.335 1:161510915-161511163 L2c 1:161511570-161511646 L3 1:161479597-161518642 1:161479597-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);2D-1 (FCGR3A,+0.00);3A (1 gene, +0.00);5F (+0.00) 1 -1_161511000_161511600_DEL_1 1 161511000 161511600 -600 DEL split q23.3 FCGR3A NM_000569 161511549 161519608 51 0 0 no 5 exon5-txEnd 3'UTR 1389 3' 161511549 161511600 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=1 -1_161511000_161519950_DEL_1 1 161511000 161519950 -8950 DEL full q23.3 FCGR3A 1 ATF6 (morbid/RE=EA_enhancer);MPZ (morbid/RE=EA_enhancer);SDHC (HI=3/morbid/RE=EA_enhancer) dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00;0.01;0.03;0.05 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.01;0.05;0.06;0.09;0.12;0.15;0.35;93.57 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;1000g;esv3587731;DDD:3093 1:161484999-161522125;1:161519612-161593482;1:161519612-161593482;1:161488421-161634845 0.435 0.545 1:161510915-161511163 L2c 1:161479597-161518642 1:161518643-161565122 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);3A (1 gene, +0.00);5F (+0.00) 1 -1_161511000_161519950_DEL_1 1 161511000 161519950 -8950 DEL split q23.3 FCGR3A NM_001127592 161511549 161519893 8344 1077 100 no 5 txStart-txEnd 5'UTR-3'UTR 161511549 161519893 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=1 -1_161512000_161512500_DEL_1 1 161512000 161512500 -500 DEL full q23.3 FCGR3A 1 dbVar:nssv15127572;dbVar:nssv15133506;dbVar:nssv15148250;dbVar:nssv15149867;nssv15151118;dbVar:nssv15156967;dbVar:nssv15156970 1:145764499-249233096;1:149825831-180236332;1:157717036-175990383;1:47851-249228449;1:82154-249218992;1:849467-249224684 0.00 Immunodeficiency 20, 615707 (3) AR dbVar:nssv15129680;dbVar:nssv15132112;dbVar:nssv15143225;dbVar:nssv15156891;dbVar:nssv15606086;dbVar:nssv15777243;dbVar:nssv17970186;morbid:FCGR3A 1:146053394-249233096;1:157321299-167391423;1:159343438-161918472;1:159449677-166864323;1:159815642-177026983;1:160369890-175796325;1:160417296-166197042;1:161511549-161520527 0.00;0.01;0.02;5.57 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 gnomAD-SV_v2.1_DUP_1_2490;1000g;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;DDD:3093;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 gnomAD-SV_v2.1_DEL_1_8642;DDD:3093 1:161484999-161522125;1:161488421-161634845 0.490 0.360 1:161479597-161518642 1:161479597-161518642 92.43 0.0515701444991238 -0.213860724130331 146740 yes 3.6955e-06 1.2227e-05 -1.0 1A (cf Gene_count, RE_gene, +0.00);2F/4O (cf B_loss_source, -1.00);2B (cf po_P_loss_source, HI and OMIM_morbid, +0.00);2D-1 (FCGR3A,+0.00);3A (1 gene, +0.00);5F (+0.00) 1 -1_161512000_161512500_DEL_1 1 161512000 161512500 -500 DEL split q23.3 FCGR3A NM_000569 161511549 161519608 500 0 0 no 5 exon5-exon5 3'UTR 489 3' 161512000 161512500 1000g;DDD:3093;esv3587730;gnomAD-SV_v2.1_DUP_1_2488;gnomAD-SV_v2.1_DUP_1_2490;nsv514915 1:161484699-161541000;1:161488444-161519959;1:161488444-161519959;1:161482999-161621200;1:161488421-161634845;1:161509488-161646576 0.1000 DDD:3093;gnomAD-SV_v2.1_DEL_1_8642 1:161484999-161522125;1:161488421-161634845 0.0769 92.43 0.0515701444991238 -0.213860724130331 autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity AR Supportive 23006327[PMID] 146740 Immunodeficiency 20, 615707 (3) AR AR yes 8 3.6955e-06 1.2227e-05 full=1 diff --git a/tests/data/test_11_RamTracking/ramAnnotSV-ena-ram.txt b/tests/data/test_11_RamTracking/ramAnnotSV-ena-ram.txt deleted file mode 100644 index a419f18..0000000 --- a/tests/data/test_11_RamTracking/ramAnnotSV-ena-ram.txt +++ /dev/null @@ -1,2954 +0,0 @@ -109576 -15076 -109576 -15164 -109576 -16484 -109576 -15612 -109576 -15612 -109576 -15612 -109576 -15612 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15628 -109576 -15652 -109576 -18492 -109576 -19644 -109576 -21276 -109576 -21276 -109576 -21292 -109576 -21292 -109576 -21324 -109576 -21424 -109576 -21424 -109576 -21424 -109576 -21480 -109576 -23516 -109576 -27900 -109576 -33180 -110632 -39660 -123428 -41984 -124416 -46196 -124416 -50416 -124416 -54500 -124416 -54500 -124416 -55000 -124416 -57368 -124416 -60484 -124416 -64092 -124416 -66668 -125796 -68752 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100644 index a0d0fda..0000000 --- a/tests/data/test_11_RamTracking/tutu.log +++ /dev/null @@ -1,152 +0,0 @@ -AnnotSV 3.3.6 - -Copyright (C) 2017-2023 GEOFFROY Veronique - -Please feel free to contact me for any suggestions or bug reports -email: veronique.geoffroy@inserm.fr - -Tcl/Tk version: 8.6 - -Application name used: -/gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.3.4 - - -...downloading the configuration data (December 22 2023 - 15:30) - ...configuration data by default - ...configuration data from /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.3.4/etc/AnnotSV/configfile - ...configuration data given in arguments - ...checking all these configuration data - -...checking the annotation data sources (December 22 2023 - 15:30) - -...listing arguments - ****************************************** - AnnotSV has been run with these arguments: - ****************************************** - -REreport 0 - -REselect1 1 - -REselect2 1 - -SVinputFile ../test_02_HG00096/input/HG00096.wgs.mergedSV.v8.20130502.svs.genotypes.bed - -SVinputInfo 1 - -SVminSize 50 - -annotationMode both - -annotationsDir /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.3.4/share/AnnotSV - -bcftools bcftools - -bedtools bedtools - -benignAF 0.01 - -candidateGenesFiltering 0 - -cytoband 1 - -genomeBuild GRCh37 - -includeCI 1 - -metrics us - -miRNAann 1 - -minTotalNumber 500 - -organism Human - -outputDir ./output - -outputFile HG00096.SV_tcl.annotated.tsv - -overlap 100 - -overwrite 1 - -promoterSize 500 - -rankFiltering 1 2 3 4 5 NA - -reciprocal 0 - -samplesidBEDcol 5 - -snvIndelFiles ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz - -snvIndelPASS 0 - -snvIndelSamples HG00096 - -svtBEDcol -1 - -tx RefSeq - -variantconvertDir /gstock/LGM/analysisOfSV/AnnotSV/AnnotSV_3.3.4/share/python3/variantconvert/ - -vcf 0 - ****************************************** - -...searching for SV overlaps with a gene or a regulatory elements - ...1436 genes overlapped with an SV - ...5303 genes regulated by a regulatory element which is overlapped with an SV - -WARNING: "SV_type" annotation is missing: -****************************************** -AnnotSV_ID SV_chrom SV_start SV_end SV_length user#1 Samples_ID Annotation_mode CytoBand Gene_name Gene_count Tx Tx_start Tx_end Overlapped_tx_length Overlapped_CDS_length Overlapped_CDS_percent Frameshift Exon_count Location Location2 Dist_nearest_SS Nearest_SS_type Intersect_start Intersect_end RE_gene P_gain_phen P_gain_hpo P_gain_source P_gain_coord P_loss_phen P_loss_hpo P_loss_source P_loss_coord P_ins_phen P_ins_hpo P_ins_source P_ins_coord po_P_gain_phen po_P_gain_hpo po_P_gain_source po_P_gain_coord po_P_gain_percent po_P_loss_phen po_P_loss_hpo po_P_loss_source po_P_loss_coord po_P_loss_percent P_snvindel_nb P_snvindel_phen B_gain_source B_gain_coord B_gain_AFmax B_loss_source B_loss_coord B_loss_AFmax B_ins_source B_ins_coord B_ins_AFmax B_inv_source B_inv_coord B_inv_AFmax po_B_gain_allG_source po_B_gain_allG_coord po_B_gain_someG_source po_B_gain_someG_coord po_B_loss_allG_source po_B_loss_allG_coord po_B_loss_someG_source po_B_loss_someG_coord Count_hom(HG00096) Count_htz(HG00096) Count_htz/allHom(HG00096) Count_htz/total(cohort) Count_total(cohort) Cosmic_ID Cosmic_mut_typ GC_content_left GC_content_right Repeat_coord_left Repeat_type_left Repeat_coord_right Repeat_type_right Gap_left Gap_right SegDup_left SegDup_right ENCODE_blacklist_left ENCODE_blacklist_characteristics_left ENCODE_blacklist_right ENCODE_blacklist_characteristics_right ACMG HI TS DDD_HI_percent ExAC_delZ ExAC_dupZ ExAC_cnvZ ExAC_synZ ExAC_misZ GenCC_disease GenCC_moi GenCC_classification GenCC_pmid OMIM_ID OMIM_phenotype OMIM_inheritance OMIM_morbid OMIM_morbid_candidate LOEUF_bin GnomAD_pLI ExAC_pLI -****************************************** - => No ranking provided - - -WARNING: AnnotSV requires the SV type (duplication, deletion...) to classify the SV - Not provided (svtBEDcol = -1) - => No SV ranking (ACMG_class feature will be set to "NA") - -...listing of the annotations to be realized (December 22 2023 - 15:31) - ...CytoBand annotation - ...Genes annotation - ...RefSeq annotation - ...Regulatory elements annotations - ...Promoter annotations - ...EnhancerAtlas annotations - ...GeneHancer annotations - ...Annotations with pathogenic genes or genomic regions - ...dbVar annotation - ...ClinVar annotation - ...ClinGen annotation - ...Annotations with pathogenic snv/indel - ...Annotations with benign genes or genomic regions - ...gnomAD annotation - ...ClinVar annotation - ...ClinGen annotation - ...DGV annotation - ...DDD annotation - ...1000g annotation - ...Ira M. Hall's lab annotation - ...Children’s Mercy Research Institute - ...Annotations with features overlapped with the SV (100 %) - ...CosmicCompleteCNA_GRCh37.sorted.formatted.sorted.bed - (2 annotations columns: Cosmic_ID, Cosmic_mut_typ) - ...Annotations with features sharing any overlap with the SV - ...Breakpoints annotations - ...GC content annotation - ...Repeat annotation - ...Gap annotation - ...Segmental duplication annotation - ...ENCODE blacklist annotation - ...Gene-based annotations - ...20220617_ACMG.tsv - (78 gene identifiers and 1 annotations columns: ACMG) - ...20220906_ClinGenAnnotations.tsv - (1480 gene identifiers and 2 annotations columns: HI, TS) - ...20200713_HI.tsv.gz - (19124 gene identifiers and 1 annotations columns: DDD_HI_percent) - ...20191219_ExAC.CNV-Zscore.annotations.tsv.gz - (15673 gene identifiers and 3 annotations columns: ExAC_delZ, ExAC_dupZ, ExAC_cnvZ) - ...20201023_GeneIntolerance-Zscore.annotations.tsv.gz - (18241 gene identifiers and 2 annotations columns: ExAC_synZ, ExAC_misZ) - ...20220902_GenCC.tsv - (4615 gene identifiers and 4 annotations columns: GenCC_disease, GenCC_moi, GenCC_classification, GenCC_pmid) - ...20220905_OMIM-1-annotations.tsv.gz - (16250 gene identifiers and 1 annotations columns: OMIM_ID) - ...20220905_OMIM-2-annotations.tsv.gz - (16250 gene identifiers and 2 annotations columns: OMIM_phenotype, OMIM_inheritance) - ...20220905_morbid.tsv.gz - (12998 gene identifiers and 1 annotations columns: OMIM_morbid) - ...20220905_morbidCandidate.tsv.gz - (3467 gene identifiers and 1 annotations columns: OMIM_morbid_candidate) - ...20201106_gnomAD.LOEUF.pLI.annotations.tsv.gz - (19451 gene identifiers and 3 annotations columns: LOEUF_bin, GnomAD_pLI, ExAC_pLI) - -...annotation in progress (December 22 2023 - 15:31) - - -...parsing of snvIndelFiles for "HG00096" (December 22 2023 - 15:32) - ...split multiallelic sites into multiple rows for ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz (December 22 2023 - 15:32) - -- VCFannotation -- - bcftools norm -m -both ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz > ./output/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz.1703255535.separate.vcf - Error: wrong number of fields in INFO/DP at 1:15274, expected 2, found 1 - => No multiallelic treatment done. - ...parsing of ./input/HG00096.chr1.phase3_shapeit2_mvncall_integrated_v5_extra_anno.20130502.genotypes.withoutSV.filtered.vcf.gz (December 22 2023 - 15:32) - -> 44 SNV/indel located in all the SV (potentially with redundancy depending on SV overlap) - -> 44 SNV/indel loaded - -...writing of ./output/HG00096.SV_tcl.annotated.tsv (December 22 2023 - 15:32) - -...output columns annotation (December 22 2023 - 15:32): - AnnotSV_ID;SV_chrom;SV_start;SV_end;SV_length;user#1;Samples_ID;Annotation_mode;CytoBand;Gene_name;Gene_count;Tx;Tx_start;Tx_end;Overlapped_tx_length;Overlapped_CDS_length;Overlapped_CDS_percent;Frameshift;Exon_count;Location;Location2;Dist_nearest_SS;Nearest_SS_type;Intersect_start;Intersect_end;RE_gene;P_gain_phen;P_gain_hpo;P_gain_source;P_gain_coord;P_loss_phen;P_loss_hpo;P_loss_source;P_loss_coord;P_ins_phen;P_ins_hpo;P_ins_source;P_ins_coord;po_P_gain_phen;po_P_gain_hpo;po_P_gain_source;po_P_gain_coord;po_P_gain_percent;po_P_loss_phen;po_P_loss_hpo;po_P_loss_source;po_P_loss_coord;po_P_loss_percent;P_snvindel_nb;P_snvindel_phen;B_gain_source;B_gain_coord;B_gain_AFmax;B_loss_source;B_loss_coord;B_loss_AFmax;B_ins_source;B_ins_coord;B_ins_AFmax;B_inv_source;B_inv_coord;B_inv_AFmax;po_B_gain_allG_source;po_B_gain_allG_coord;po_B_gain_someG_source;po_B_gain_someG_coord;po_B_loss_allG_source;po_B_loss_allG_coord;po_B_loss_someG_source;po_B_loss_someG_coord;Count_hom(HG00096);Count_htz(HG00096);Count_htz/allHom(HG00096);Count_htz/total(cohort);Count_total(cohort);Cosmic_ID;Cosmic_mut_typ;GC_content_left;GC_content_right;Repeat_coord_left;Repeat_type_left;Repeat_coord_right;Repeat_type_right;Gap_left;Gap_right;SegDup_left;SegDup_right;ENCODE_blacklist_left;ENCODE_blacklist_characteristics_left;ENCODE_blacklist_right;ENCODE_blacklist_characteristics_right;ACMG;HI;TS;DDD_HI_percent;ExAC_delZ;ExAC_dupZ;ExAC_cnvZ;ExAC_synZ;ExAC_misZ;GenCC_disease;GenCC_moi;GenCC_classification;GenCC_pmid;OMIM_ID;OMIM_phenotype;OMIM_inheritance;OMIM_morbid;OMIM_morbid_candidate;LOEUF_bin;GnomAD_pLI;ExAC_pLI;AnnotSV_ranking_score;AnnotSV_ranking_criteria;ACMG_class - - -...AnnotSV is done with the analysis (December 22 2023 - 15:32) diff --git a/tests/data/test_13_txFile/3 b/tests/data/test_13_txFile/3 deleted file mode 100644 index e69de29..0000000 diff --git a/tests/data/test_13_txFile/command_Tcl.sh b/tests/data/test_13_txFile/command_Tcl.sh deleted file mode 100755 index 07d83a5..0000000 --- a/tests/data/test_13_txFile/command_Tcl.sh +++ /dev/null @@ -1,123 +0,0 @@ -#!/bin/bash -x - -set -eo pipefail - -cut="$ANNOTSV/tests/data/scripts/cutWithColumnNames.tcl" - - -################################ -# Check the "-txFile" option -################################ - -# INFO: Transcript annotation comes from $ANNOTSV/share/AnnotSV/Annotations_Human/Genes/GRCh37/genes.RefSeq.sorted.bed - - -## Check 1: the CDK11B gene (with a BED input file) -################################################### - -# By default, the CDK11B gene is annotated with the "NM_001787" transcript (and not the "NM_033486") -rm -f "./output/test.check1_tcl.annotated.tsv" -$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check1_tcl.annotated.tsv" -svtBEDcol 5 -genomeBuild GRCh37 -annotations=`$cut "./output/test.check1_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` -if [ `echo $annotations | grep -c "NM_001787"` != 0 ] -then - echo "Ok" -else - echo "error 1: the CDK11B gene is not annotated with the NM_001787 transcript" - exit 1 -fi - - -# Changing of the transcript default: -# => "NM_033486" transcript is given in the "txFile.check1.txt" file -rm -f "./output/test.check1.WithTx_tcl.annotated.tsv" -$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check1.WithTx_tcl.annotated.tsv" -svtBEDcol 5 -txFile "./input/txFile.check1.txt" -genomeBuild GRCh37 -annotations=`$cut "./output/test.check1.WithTx_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` -#=> Now, the CDK11B gene is annotated with "NM_033486" -if [ `echo $annotations | grep -c "NM_033486"` != 0 ] -then - echo "Ok" -else - echo "error 1: the CDK11B gene is not annotated with the NM_033486 transcript" - exit 1 -fi - - -## Check 2: the NAV1 gene (with a VCF input file) -################################################# - -# By default, the NAV1 gene is annotated with the "NM_020443" transcript (and not the "NM_001167738") -rm -f "./output/test.check2_tcl.annotated.tsv" -$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check2.vcf" -outputFile "./output/test.check2_tcl.annotated.tsv" -genomeBuild GRCh37 -annotations=`$cut "./output/test.check2_tcl.annotated.tsv" "Gene_name;Tx" | grep "NAV1"` -if [ `echo $annotations | grep -c "NM_020443"` != 0 ] -then - echo "Ok" -else - echo "error 1: the NAV1 gene is not annotated with the NM_020443 transcript" - exit 1 -fi - - -# Changing of the transcript default: -# => "NM_001167738" transcript is given in the "txfile.check2.txt" file -rm -f "./output/test.check2.WithTx_tcl.annotated.tsv" -$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check2.vcf" -outputFile "./output/test.check2.WithTx_tcl.annotated.tsv" -txFile "./input/txFile.check2.txt" -genomeBuild GRCh37 -annotations=`$cut "./output/test.check2.WithTx_tcl.annotated.tsv" "Gene_name;Tx" | grep "NAV1"` -#=> Now, the NAV1 gene is annotated with "NM_001167738" -if [ `echo $annotations | grep -c "NM_001167738"` != 0 ] -then - echo "Ok" -else - echo "error 1: the NAV1 gene is not annotated with the NM_001167738 transcript" - exit 1 -fi - - - -############################ -# Check the "-tx" option -############################ - -## Check 3 -########## - -# By default, tx="RefSeq" -# Check with tx="ENSEMBL" -rm -f "./output/test.check3_tcl.annotated.tsv" -$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check3_tcl.annotated.tsv" -svtBEDcol 5 -tx "ENSEMBL" -genomeBuild GRCh38 -annotations=`$cut "./output/test.check3_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` -if [ `echo $annotations | grep -c "ENST00000407249"` != 0 ] -then - echo "Ok" -else - echo "error 1: the CDK11B gene is not annotated with the ENST00000407249 transcript" - exit 1 -fi - - -# Changing of the transcript default: -# => "ENST00000341832" transcript is given in the "txfile.check3.txt" file -rm -f "./output/test.check3.WithTx_tcl.annotated.tsv" -$ANNOTSV/bin/AnnotSV -SVinputFile "./input/test.check1.bed" -outputFile "./output/test.check3.WithTx_tcl.annotated.tsv" -txFile "./input/txFile.check3.txt" -svtBEDcol 5 -tx "ENSEMBL" -genomeBuild GRCh38 -annotations=`$cut "./output/test.check3.WithTx_tcl.annotated.tsv" "Gene_name;Tx" | grep "CDK11B"` -#=> Now, the CDK11B gene is annotated with "ENST00000341832" -if [ `echo $annotations | grep -c "ENST00000341832"` != 0 ] -then - echo "Ok" -else - echo "error 1: the CDK11B gene is not annotated with the ENST00000341832 transcript" - exit 1 -fi - - - - -echo "ok - Finished" - - - - - - - diff --git a/tests/data/test_29_distNearestSS/input/test1.vcf b/tests/data/test_29_distNearestSS/input/test1.vcf deleted file mode 100755 index 97a1b00..0000000 --- a/tests/data/test_29_distNearestSS/input/test1.vcf +++ /dev/null @@ -1,2 +0,0 @@ -#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT ALBS -chr8 7366741 DRAGEN:LOSS:chr8:7366742-7368724 N 12 cnvLength SVLEN=-1983;SVTYPE=CNV;END=7368724;REFLEN=1983 GT:SM:CN:BC:PE 0/1:0.604884:1:1:2,2 diff --git a/tests/data/test_29_distNearestSS/input/test6.bed b/tests/data/test_29_distNearestSS/input/test6.bed deleted file mode 100755 index 31ef01d..0000000 --- a/tests/data/test_29_distNearestSS/input/test6.bed +++ /dev/null @@ -1 +0,0 @@ -11 7716903 7717219 DEL

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