Can this tool also be used with human WGS data?

[robertzeibich]

No description provided.

[johli]

Sorry for the late response. Yes, you can use APARENT to score any set of mutations occurring within a polyA signal sequence, including variants called from WGS data. Though we don't have a particular script/notebook for that kind of analysis specifically.

Batched variant scoring example: https://github.com/johli/aparent/blob/master/misc/predict_variants/predict_variants_polyadb_no_sequences.ipynb

Also check out the newer APARENT2 model: https://github.com/johli/aparent-resnet/blob/master/examples/aparent2_score_variants.ipynb