From 91b8908433c84b7aa88e15c319288e0e4b43a7fa Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Wed, 12 Jun 2024 19:01:32 +0200 Subject: [PATCH 1/7] stable --- .../_snaps/stable/tables-efficacy-mmrmt01.md | 29 ++++++++++++++++ .../_snaps/stable/tables-efficacy-rbmit01.md | 34 +++++++++---------- .../_snaps/stable/tables-lab-results-lbt11.md | 6 ++-- .../stable/tables-lab-results-lbt11_bl.md | 6 ++-- 4 files changed, 52 insertions(+), 23 deletions(-) diff --git a/package/tests/testthat/_snaps/stable/tables-efficacy-mmrmt01.md b/package/tests/testthat/_snaps/stable/tables-efficacy-mmrmt01.md index 7651df082f..138240e761 100644 --- a/package/tests/testthat/_snaps/stable/tables-efficacy-mmrmt01.md +++ b/package/tests/testthat/_snaps/stable/tables-efficacy-mmrmt01.md @@ -149,3 +149,32 @@ Relative Increase (%) 8.7% 4.3% p-value (MMRM) 0.0324 0.2924 +# tables/efficacy/mmrmt01.qmd result_baseline stable + + Code + print(data_snap[[i]]) + Output + Visit All Patients + Statistics (N=400) + ——————————————————————————————————————— + WEEK 1 DAY 8 + n 400 + Adjusted Mean (SE) 3.615 (0.620) + 95% CI (2.396, 4.834) + WEEK 2 DAY 15 + n 400 + Adjusted Mean (SE) 8.870 (0.602) + 95% CI (7.687, 10.053) + WEEK 3 DAY 22 + n 400 + Adjusted Mean (SE) 15.094 (0.683) + 95% CI (13.751, 16.437) + WEEK 4 DAY 29 + n 400 + Adjusted Mean (SE) 19.009 (0.717) + 95% CI (17.599, 20.418) + WEEK 5 DAY 36 + n 400 + Adjusted Mean (SE) 24.028 (0.747) + 95% CI (22.560, 25.496) + diff --git a/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md b/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md index 4242c9d782..7e93ad6359 100644 --- a/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md +++ b/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md @@ -13,24 +13,24 @@ Relative Reduction (%) 5.7% p-value (RBMI) 0.8932 5 - Adjusted Mean (SE) -4.241 (0.646) -2.814 (0.643) - 95% CI (-5.537, -2.984) (-4.084, -1.545) - Difference in Adjusted Means (SE) 1.447 (0.915) - 95% CI (-0.360, 3.254) - Relative Reduction (%) -34.0% - p-value (RBMI) 0.1159 + Adjusted Mean (SE) -4.256 (0.649) -2.822 (0.646) + 95% CI (-5.538, -2.974) (-4.098, -1.545) + Difference in Adjusted Means (SE) 1.434 (0.920) + 95% CI (-0.383, 3.252) + Relative Reduction (%) -33.7% + p-value (RBMI) 0.1211 6 - Adjusted Mean (SE) -6.365 (0.721) -4.123 (0.689) - 95% CI (-7.791, -4.939) (-5.484, -2.761) - Difference in Adjusted Means (SE) 2.242 (0.998) - 95% CI (0.269, 4.216) - Relative Reduction (%) -35.2% - p-value (RBMI) 0.0262 + Adjusted Mean (SE) -6.373 (0.716) -4.164 (0.689) + 95% CI (-7.789, -4.956) (-5.524, -2.803) + Difference in Adjusted Means (SE) 2.209 (0.990) + 95% CI (0.253, 4.165) + Relative Reduction (%) -34.7% + p-value (RBMI) 0.0271 7 - Adjusted Mean (SE) -7.665 (0.831) -4.802 (0.762) - 95% CI (-9.314, -6.017) (-6.308, -3.296) - Difference in Adjusted Means (SE) 2.863 (1.120) - 95% CI (0.645, 5.082) - Relative Reduction (%) -37.4% + Adjusted Mean (SE) -7.640 (0.822) -4.823 (0.767) + 95% CI (-9.270, -6.010) (-6.341, -3.306) + Difference in Adjusted Means (SE) 2.816 (1.103) + 95% CI (0.634, 4.999) + Relative Reduction (%) -36.9% p-value (RBMI) 0.0118 diff --git a/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11.md b/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11.md index 32c8a8d526..7a4c838705 100644 --- a/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11.md +++ b/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11.md @@ -66,9 +66,9 @@ Hazard Ratio 0.43 0.58 95% CI (0.19, 0.94) (0.26, 1.27) Stratified By: RACE, SEX - p-value (log-rank) 0.0295 0.1687 - Hazard Ratio 0.43 0.58 - 95% CI (0.19, 0.94) (0.26, 1.27) + p-value (log-rank) 0.0858 0.1605 + Hazard Ratio 0.51 0.57 + 95% CI (0.23, 1.12) (0.26, 1.26) ——————————————————————————————————————————————————————————————————————————————————————— {1} - Censored observations: range minimum & maximum diff --git a/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11_bl.md b/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11_bl.md index 23e0c6119b..513d6f6e2f 100644 --- a/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11_bl.md +++ b/package/tests/testthat/_snaps/stable/tables-lab-results-lbt11_bl.md @@ -64,9 +64,9 @@ Hazard Ratio 1.27 0.84 95% CI (0.63, 2.56) (0.40, 1.75) Stratified By: RACE, SEX - p-value (log-rank) 0.0858 0.1605 - Hazard Ratio 0.51 0.57 - 95% CI (0.23, 1.12) (0.26, 1.26) + p-value (log-rank) 0.3886 0.7970 + Hazard Ratio 1.39 0.91 + 95% CI (0.65, 2.97) (0.43, 1.93) ——————————————————————————————————————————————————————————————————————————————————————— {1} - Censored observations: range minimum & maximum From a132848f78210863c4781c80604cc39c0cb4730c Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Wed, 12 Jun 2024 19:04:58 +0200 Subject: [PATCH 2/7] devel --- .../development/tables-efficacy-mmrmt01.md | 33 +++++++++++++++-- .../development/tables-efficacy-rbmit01.md | 36 +++++++++---------- 2 files changed, 49 insertions(+), 20 deletions(-) diff --git a/package/tests/testthat/_snaps/development/tables-efficacy-mmrmt01.md b/package/tests/testthat/_snaps/development/tables-efficacy-mmrmt01.md index 3f35fd0afa..7efad52641 100644 --- a/package/tests/testthat/_snaps/development/tables-efficacy-mmrmt01.md +++ b/package/tests/testthat/_snaps/development/tables-efficacy-mmrmt01.md @@ -13,7 +13,7 @@ Difference in Adjusted Means (SE) 0.759 (0.973) -0.325 (0.976) 95% CI (-1.155, 2.672) (-2.243, 1.593) Relative Increase (%) 21.8% -9.3% - p-value (MMRM) 0.4362 0.7394 + p-value (MMRM) 0.4362 0.7393 WEEK 2 DAY 15 n 134 134 132 Adjusted Mean (SE) 9.135 (0.768) 9.018 (0.767) 8.509 (0.773) @@ -21,7 +21,7 @@ Difference in Adjusted Means (SE) -0.117 (1.087) -0.626 (1.090) 95% CI (-2.253, 2.020) (-2.768, 1.517) Relative Increase (%) -1.3% -6.8% - p-value (MMRM) 0.9146 0.5662 + p-value (MMRM) 0.9147 0.5662 WEEK 3 DAY 22 n 134 134 132 Adjusted Mean (SE) 13.547 (0.871) 16.014 (0.871) 15.789 (0.877) @@ -149,3 +149,32 @@ Relative Increase (%) 8.7% 4.3% p-value (MMRM) 0.0324 0.2924 +# tables/efficacy/mmrmt01.qmd result_baseline development + + Code + print(data_snap[[i]]) + Output + Visit All Patients + Statistics (N=400) + ——————————————————————————————————————— + WEEK 1 DAY 8 + n 400 + Adjusted Mean (SE) 3.615 (0.620) + 95% CI (2.396, 4.834) + WEEK 2 DAY 15 + n 400 + Adjusted Mean (SE) 8.870 (0.602) + 95% CI (7.687, 10.053) + WEEK 3 DAY 22 + n 400 + Adjusted Mean (SE) 15.094 (0.683) + 95% CI (13.751, 16.437) + WEEK 4 DAY 29 + n 400 + Adjusted Mean (SE) 19.009 (0.717) + 95% CI (17.599, 20.418) + WEEK 5 DAY 36 + n 400 + Adjusted Mean (SE) 24.028 (0.747) + 95% CI (22.560, 25.496) + diff --git a/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md b/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md index 6d60b03535..cf4408adc8 100644 --- a/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md +++ b/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md @@ -13,24 +13,24 @@ Relative Reduction (%) 5.7% p-value (RBMI) 0.8932 5 - Adjusted Mean (SE) -4.247 (0.649) -2.815 (0.646) - 95% CI (-5.527, -2.966) (-4.091, -1.540) - Difference in Adjusted Means (SE) 1.431 (0.915) - 95% CI (-0.377, 3.239) - Relative Reduction (%) -33.7% - p-value (RBMI) 0.1200 + Adjusted Mean (SE) -4.253 (0.651) -2.812 (0.645) + 95% CI (-5.539, -2.968) (-4.087, -1.537) + Difference in Adjusted Means (SE) 1.442 (0.921) + 95% CI (-0.377, 3.261) + Relative Reduction (%) -33.9% + p-value (RBMI) 0.1195 6 - Adjusted Mean (SE) -6.388 (0.724) -4.115 (0.692) - 95% CI (-7.820, -4.956) (-5.481, -2.748) - Difference in Adjusted Means (SE) 2.274 (1.005) - 95% CI (0.287, 4.261) - Relative Reduction (%) -35.6% - p-value (RBMI) 0.0252 + Adjusted Mean (SE) -6.359 (0.724) -4.126 (0.696) + 95% CI (-7.791, -4.927) (-5.502, -2.749) + Difference in Adjusted Means (SE) 2.234 (1.000) + 95% CI (0.258, 4.210) + Relative Reduction (%) -35.1% + p-value (RBMI) 0.0270 7 - Adjusted Mean (SE) -7.649 (0.792) -4.812 (0.764) - 95% CI (-9.217, -6.081) (-6.323, -3.301) - Difference in Adjusted Means (SE) 2.836 (1.121) - 95% CI (0.617, 5.056) - Relative Reduction (%) -37.1% - p-value (RBMI) 0.0127 + Adjusted Mean (SE) -7.612 (0.822) -4.819 (0.767) + 95% CI (-9.242, -5.982) (-6.335, -3.302) + Difference in Adjusted Means (SE) 2.793 (1.110) + 95% CI (0.597, 4.989) + Relative Reduction (%) -36.7% + p-value (RBMI) 0.0131 From 73d1fc24a130de1f8bb41c32ff043d9fe2b47530 Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Wed, 12 Jun 2024 19:06:45 +0200 Subject: [PATCH 3/7] rm unused snap files --- .../graphs-efficacy-fstg01/fstg01-plot_v1.svg | 147 - .../graphs-efficacy-fstg01/fstg01-plot_v2.svg | 147 - .../graphs-efficacy-fstg01/fstg01-plot_v3.svg | 101 - .../graphs-efficacy-fstg01/fstg01-plot_v4.svg | 147 - 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100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg04/pkpg04-plot_v1.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v1.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v2.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v3.svg delete mode 100644 package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v4.svg diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v1.svg deleted file mode 100644 index c4afd9cba9..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v1.svg +++ /dev/null @@ -1,147 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -B: Placebo - -A: Drug X - -Baseline Risk Factors -All Patients -Sex - F - M -Categorical Level Biomarker 2 - LOW - MEDIUM - HIGH -Total n -268 -161 -107 -95 -93 -80 -n -134 -82 -52 -45 -56 -33 -Responders -84 -48 -36 -30 -34 -20 -Response (%) -62.7% -58.5% -69.2% -66.7% -60.7% -60.6% -n -134 -79 -55 -50 -37 -47 -Responders -100 -61 -39 -39 -27 -34 -Response (%) -74.6% -77.2% -70.9% -78.0% -73.0% -72.3% -Odds Ratio -1.76 -2.45 -1.08 -1.77 -1.73 -1.73 -95% CI -(1.04, 2.97) -(1.23, 4.86) -(0.48, 2.46) -(0.71, 4.39) -(0.71, 4.22) -(0.67, 4.44) - - - - - - - - - - - - - - - -B: Placebo -Better -A: Drug X -Better - - - - - - - - - - - - - - - - -0.1 -1 -10 - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v2.svg deleted file mode 100644 index 79bde9f5bc..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v2.svg +++ /dev/null @@ -1,147 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -ARM B - -ARM A/ARM C - -Baseline Risk Factors -All Patients -Sex - M - F -Categorical Level Biomarker 2 - LOW - MEDIUM - HIGH -Total n -400 -169 -231 -135 -135 -130 -n -134 -52 -82 -45 -56 -33 -Responders -84 -36 -48 -30 -34 -20 -Response (%) -62.7% -69.2% -58.5% -66.7% -60.7% -60.6% -n -266 -117 -149 -90 -79 -97 -Responders -181 -78 -103 -64 -51 -66 -Response (%) -68.0% -66.7% -69.1% -71.1% -64.6% -68.0% -Odds Ratio -1.27 -0.89 -1.57 -1.21 -1.20 -1.39 -95% CI -(0.82, 1.96) -(0.44, 1.80) -(0.90, 2.75) -(0.56, 2.61) -(0.59, 2.44) -(0.61, 3.13) - - - - - - - - - - - - - - - -ARM B -Better -ARM A/ARM C -Better - - - - - - - - - - - - - - - - -0.1 -1 -10 - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v3.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v3.svg deleted file mode 100644 index 16f53a1124..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v3.svg +++ /dev/null @@ -1,101 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -Baseline Risk Factors -All Patients -Sex - F - M -Categorical Level Biomarker 2 - LOW - MEDIUM - HIGH -Total n -268 -161 -107 -95 -93 -80 -Odds Ratio -1.76 -2.45 -1.08 -1.77 -1.73 -1.73 -90% CI -(1.13, 2.73) -(1.38, 4.36) -(0.54, 2.15) -(0.83, 3.79) -(0.82, 3.66) -(0.78, 3.81) - - - - - - - - - - - - - - - -B: Placebo -Better -A: Drug X -Better - - - - - - - - - - - - - - - - -0.1 -1 -10 - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v4.svg deleted file mode 100644 index 15be3fe809..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v4.svg +++ /dev/null @@ -1,147 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -B: Placebo - -A: Drug X - -Baseline Risk Factors -All Patients -Sex - F - M -Categorical Level Biomarker 2 - LOW - MEDIUM - HIGH -Total n -268 -161 -107 -95 -93 -80 -n -134 -82 -52 -45 -56 -33 -Responders -84 -48 -36 -30 -34 -20 -Response (%) -62.7% -58.5% -69.2% -66.7% -60.7% -60.6% -n -134 -79 -55 -50 -37 -47 -Responders -100 -61 -39 -39 -27 -34 -Response (%) -74.6% -77.2% -70.9% -78.0% -73.0% -72.3% -Odds Ratio -1.76 -2.45 -1.08 -1.77 -1.73 -1.73 -95% CI -(1.04, 2.97) -(1.23, 4.86) -(0.48, 2.46) -(0.71, 4.39) -(0.71, 4.22) -(0.67, 4.44) - - - - - - - - - - - - - - - -B: Placebo -Better -A: Drug X -Better - - - - - - - - - - - - - - - - -0.1 -1 -10 - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v5.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v5.svg deleted file mode 100644 index 4d35581773..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg01/fstg01-plot_v5.svg +++ /dev/null @@ -1,147 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -B: Placebo - -A: Drug X - -Baseline Risk Factors -All Patients -Sex - F - M -Categorical Level Biomarker 2 - LOW - MEDIUM - HIGH -Total n -268 -161 -107 -95 -93 -80 -n -134 -82 -52 -45 -56 -33 -Responders -47 -25 -22 -21 -16 -10 -Response (%) -35.1% -30.5% -42.3% -46.7% -28.6% -30.3% -n -134 -79 -55 -50 -37 -47 -Responders -60 -39 -21 -27 -19 -14 -Response (%) -44.8% -49.4% -38.2% -54.0% -51.4% -29.8% -Odds Ratio -1.52 -2.32 -0.84 -1.43 -2.60 -0.99 -95% CI -(0.93, 2.48) -(1.21, 4.45) -(0.39, 1.82) -(0.63, 3.24) 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- - - - - - - - - - - - - -A: Drug X -Better -B: Placebo -Better - - - - - - - - - - - - - - - - -0.1 -1 -10 - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg02/fstg02-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-fstg02/fstg02-plot_v2.svg deleted file mode 100644 index 9f2b20f1d8..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-fstg02/fstg02-plot_v2.svg +++ /dev/null @@ -1,133 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -Placebo - -Drug X - -Baseline Risk Factors -All Patients -Sex - M - F -Stratification Factor 1 - C - B - A -Total n -268 -107 -161 -94 -92 -82 -n -134 -52 -82 -45 -45 -44 -Median (Months) -NA -NA -NA -NA -NA -NA -n -134 -55 -79 -49 -47 -38 -Median (Months) -NA -9.6 -NA -NA -NA -NA -Hazard Ratio -1.00 -1.39 -0.79 -0.75 -1.34 -1.02 -95% Wald CI -(0.69, 1.44) -(0.78, 2.47) -(0.49, 1.28) -(0.41, 1.38) -(0.71, 2.54) -(0.53, 1.97) - - - - - - - - - - - - - - - -Drug X -Better -Placebo 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Error -LS mean -n -95% CI -Std. Error -LS mean -n -95% CI -Std. Error -LS mean -n - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v4.svg deleted file mode 100644 index 63aaf983f7..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v4.svg +++ /dev/null @@ -1,137 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.5235 -0.6112 -0.4924 -0.6772 -0.8504 -0.5140 -0.0528 -0.0800 -0.3593 -0.3480 -0.3704 -0.9378 - -Contrasts of FKSI-FWB means - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 --2.5 -0.0 -2.5 -5.0 - - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - -B: Placebo -A: Drug X -C: Combination - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v5.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v5.svg deleted file mode 100644 index 0200efaede..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v5.svg +++ /dev/null @@ -1,2740 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING - - - - - - - - - - -WEEK 1 DAY 8 - - - - - - - - - - -WEEK 2 DAY 15 - - - - - - - - - - -WEEK 3 DAY 22 - - - - - - - - - - -WEEK 4 DAY 29 - - - - - - - - - - -WEEK 5 DAY 36 - - - - - - -44.6 -44.8 -45.0 -45.2 - - - - -54.0 -54.3 -54.6 -54.9 - - - - - -59.2 -59.4 -59.6 -59.8 -60.0 - - -65 -66 - - - - -69.2 -69.6 -70.0 -70.4 - - - -74.5 -75.0 -75.5 --40 --20 -0 -20 -40 - - - - - -Fitted values -Residuals - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v6.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v6.svg deleted file mode 100644 index c1dbba5a11..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg01/mmrmg01-plot_v6.svg +++ /dev/null @@ -1,2686 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING - - - - - - - - - - -WEEK 1 DAY 8 - - - - - - - - - - -WEEK 2 DAY 15 - - - - - - - - - - -WEEK 3 DAY 22 - - - - - - - - - - -WEEK 4 DAY 29 - - - - - - - - - - -WEEK 5 DAY 36 - - - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 --2 -0 -2 - - - -Standard normal quantiles -Standardized residuals - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg02/mmrmg02-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg02/mmrmg02-plot_v1.svg deleted file mode 100644 index a656fa39bd..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg02/mmrmg02-plot_v1.svg +++ /dev/null @@ -1,103 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -Baseline Risk Factors -All Patients -group - subpopulation 1 - subpopulation 2 -SEX - F - M -Total n -393 -125 -268 -240 -153 -Mean Difference --1.3 --0.5 --1.1 --1.4 --1.2 -95% CI -(-3.3, 0.6) -(-3.4, 2.4) -(-3.2, 0.9) -(-4.0, 1.2) -(-4.1, 1.7) -p-value -0.1813 -0.7380 -0.2798 -0.2918 -0.4276 - - - - - - - - - - - - - - - -ARM B -Higher -ARM A -Higher - - - - - - - - - - - - - - - --5 --2.5 -0 -2.5 - - diff --git a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg02/mmrmg02-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg02/mmrmg02-plot_v2.svg deleted file mode 100644 index 04d4db607e..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-efficacy-mmrmg02/mmrmg02-plot_v2.svg +++ /dev/null @@ -1,103 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -Baseline Risk Factors -All Patients -group - subpopulation 1 - subpopulation 2 -SEX - F - M -Total n -383 -117 -266 -217 -166 -Mean Difference --1.4 --1.6 --1.0 --2.2 --0.4 -95% CI -(-3.3, 0.6) -(-4.7, 1.4) -(-3.1, 1.1) -(-4.9, 0.5) -(-3.2, 2.4) -p-value -0.1659 -0.2921 -0.3605 -0.1156 -0.7911 - - - - - - - - - - - - - - - -ARM B -Higher -ARM C -Higher - - - - - - - - - - - - - - - --5 --2.5 -0 -2.5 - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v1.svg deleted file mode 100644 index ca0f848442..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v1.svg +++ /dev/null @@ -1,73 +0,0 @@ - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -25 -50 -75 - - - - - - - -A: Drug X - -N = 78 -B: Placebo - -N = 75 -C: Combination - -N = 89 -Description of Actual Arm (N = 400) -Frequency -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v4.svg deleted file mode 100644 index 5efbd0d7df..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v4.svg +++ /dev/null @@ -1,70 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X -B: Placebo -C: Combination - - - - - - - - -0 -25 -50 -75 -100 -Frequency -Description of Actual Arm (N = 400) -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v5.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v5.svg deleted file mode 100644 index 8295c9cfad..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v5.svg +++ /dev/null @@ -1,72 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -1 -2 - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percentage -Percent of Subjects with Abnormaly High ALT: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v6.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v6.svg deleted file mode 100644 index 670472b2d2..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v6.svg +++ /dev/null @@ -1,81 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 -60 -80 - - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent - -Sex - - - - -F -M -Percent of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v7.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v7.svg deleted file mode 100644 index 1345c011c3..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v7.svg +++ /dev/null @@ -1,77 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - -F -M -Sex (N = 400) -Percent - -Description of Actual Arm - - - - - - -A: Drug X -B: Placebo -C: Combination -Percent of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v8.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v8.svg deleted file mode 100644 index 730afb7fe6..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v8.svg +++ /dev/null @@ -1,107 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 -5.5 -4.25 - - -0 -2 -4 -6 - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent -Percent of Subjects with Abnormaly High CRP at Baseline - Safety-Evaluable Subjects - - - - - - - - - - - - - - - - - - -10.45 -10.34 -10.46 -10.23 -10.25 -10.33 - - -Median -Mean - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v9.svg b/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v9.svg deleted file mode 100644 index 5e0b71f5e1..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-brg01/brg01-plot_v9.svg +++ /dev/null @@ -1,96 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent - -Analysis Toxicity Grade (C) - - - - - - - - - - -1 -2 -3 -4 -5 -Percent of Subjects With AE by Highest - NCI CTCAE Grade: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v1.svg deleted file mode 100644 index cb0dc6a311..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v1.svg +++ /dev/null @@ -1,100 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v2.svg deleted file mode 100644 index 4f89a62643..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v2.svg +++ /dev/null @@ -1,93 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -10 -20 -30 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the 5th and 95th percentile. Values outside the whiskers have not been plotted. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v3.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v3.svg deleted file mode 100644 index fc2fe5785e..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v3.svg +++ /dev/null @@ -1,142 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the 5th and 95th percentile. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v4.svg deleted file mode 100644 index 0181b96e88..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v4.svg +++ /dev/null @@ -1,124 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -141 -64 -256 -102 -154 -309 -264 -68 -70 -4 -203 -44 - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the largest and smallest observed value within 1.5*IQR. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v5.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v5.svg deleted file mode 100644 index 45f3f071f0..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v5.svg +++ /dev/null @@ -1,91 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v6.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v6.svg deleted file mode 100644 index 542f77546b..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v6.svg +++ /dev/null @@ -1,216 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -Visit -ALT (U/L) - -ARMCD - - - - - - - - - - - - - - - -ARM A -ARM B -ARM C -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v7.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v7.svg deleted file mode 100644 index bcaf35ff73..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v7.svg +++ /dev/null @@ -1,219 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -AVISIT - - - - - - - - - - - - - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v8.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v8.svg deleted file mode 100644 index 6cbf07fdd1..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v8.svg +++ /dev/null @@ -1,145 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: SCREENING -Box Plot of Laboratory Test Results - - - - - - - - - - - - - - - - - - -2814 -2814 -2772 -10 -10.1 -10 -8.6 -8.5 -8.6 -8.6 - 8.4 -8.5 - 8.4 -8.6 - 8.5 -3 - 11.3 -3 - 11.6 -3 - 11.8 -0-54.24 -0-54.4 -0-44.75 - - -Min - Max -25% and 75%-ile -95% CI for Median -Median -Mean -n -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v9.svg b/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v9.svg deleted file mode 100644 index 18c0328aa8..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-bwg01/bwg01-plot_v9.svg +++ /dev/null @@ -1,125 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: SCREENING -Box Plot of Laboratory Test Results - - - - - - - - - - - - - - - - - - -2814 -2814 -2772 - - -n -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v1_and_v2.svg b/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v1_and_v2.svg deleted file mode 100644 index 3bd68d30c8..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v1_and_v2.svg +++ /dev/null @@ -1,103 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -14 -16 -18 -20 -22 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -SEX - - - - - - -F -M -Confidence Interval Plot by Treatment Group -Mean and 95% CIs for mean are displayed. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v3.svg b/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v3.svg deleted file mode 100644 index 38d5dabf66..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v3.svg +++ /dev/null @@ -1,99 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -16 -18 -20 -22 - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -STRATA2 - - - - - - -S1 -S2 -Confidence Interval Plot by Treatment Group -Mean and 95% CIs for mean are displayed. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v4.svg deleted file mode 100644 index 46b4efddde..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v4.svg +++ /dev/null @@ -1,111 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -15 -20 -25 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -STRATA1 - - - - - - - - - -A -B -C -Confidence Interval Plot by Treatment Group -Median and 95% CIs for median are displayed. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v5.svg b/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v5.svg deleted file mode 100644 index f75426473e..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-cig01/cig01-plot_v5.svg +++ /dev/null @@ -1,98 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -15.0 -17.5 -20.0 -22.5 - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -SEX - - - - - - -F -M -Confidence Interval Plot by Treatment Group -Mean and 90% CIs for mean are displayed. - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v1.svg deleted file mode 100644 index 39e0a4db84..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v1.svg +++ /dev/null @@ -1,754 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X - - - - - - - - - - -B: Placebo - - - - - - - - - - -C: Combination - - - - - - - - - - -ALT - - - - - - - - - - -CRP - - - - - - - - - - -IGA - - - - - -2 -4 -6 - - - -2 -4 -6 - - - -2 -4 -6 -0 -10 -20 -30 - - - - -7 -8 -9 -10 -11 - - - - - -2.7 -2.8 -2.9 -3.0 -3.1 - - - - - -AVISIT -AVAL - -SUBJID - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-128 -id-201 -id-220 -id-261 -id-262 -id-267 -id-378 -id-45 - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v2.svg deleted file mode 100644 index 62e0475651..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v2.svg +++ /dev/null @@ -1,757 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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-WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -0 -10 -20 -30 - - - - -7 -8 -9 -10 -11 - - - - - -2.7 -2.8 -2.9 -3.0 -3.1 - - - - - - -SUBJID - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-128 -id-201 -id-220 -id-261 -id-262 -id-267 -id-378 -id-45 - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v4.svg deleted file mode 100644 index 34acbb2c2a..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-ltg01/ltg01-plot_v4.svg +++ /dev/null @@ -1,14601 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING 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22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING 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22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 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DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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-WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Laboratory Test: ALT (U/L) -Plot of Mean and 95% Confidence Limits by Visit - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v2.svg deleted file mode 100644 index 3c6b190b16..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v2.svg +++ /dev/null @@ -1,134 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - --10 --5 -0 -5 -10 - - - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Assessment: DIABP (Pa) -Plot of Mean and 95% Confidence Intervals of Change from Baseline by Visit - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v3.svg b/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v3.svg deleted file mode 100644 index 1f1f128eaa..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v3.svg +++ /dev/null @@ -1,134 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -10 -15 -20 -25 -30 - - - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Laboratory Test: ALT (U/L) -Plot of Mean (+/-SD) - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v4.svg b/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v4.svg deleted file mode 100644 index a1e019cb6d..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v4.svg +++ /dev/null @@ -1,134 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -16 -17 -18 -19 -20 - - - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Laboratory Test: ALT (U/L) -Plot of Mean and 80% Confidence Limits by Visit - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v5.svg b/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v5.svg deleted file mode 100644 index 5f62f27633..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v5.svg +++ /dev/null @@ -1,230 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -16 -18 -20 - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Laboratory Test: ALT (U/L) -Plot of Mean and 95% Confidence Limits by Visit - - - - - - - - - - - - - - - - - - -134 -134 -134 -134 -134 - - - - - - - - - - -134 -134 -134 -134 -134 - - - - - - - - - - -132 -132 -132 -132 -132 - - - - - - - - - - -C: Combination - - - - - - - - - - -B: Placebo - - - - - - - - - - -A: Drug X - - -n -n -n - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v6.svg b/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v6.svg deleted file mode 100644 index f6c46eaf2e..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v6.svg +++ /dev/null @@ -1,266 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -16 -18 -20 - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Laboratory Test: ALT (U/L) -Plot of Mean and 95% Confidence Limits by Visit - - - - - - - - - - - - - - - - - - -134 -16.8 -(15.20, 18.30) -134 -17.8 -(16.18, 19.46) -134 -18.4 -(16.78, 19.96) -134 -19.2 -(17.30, 21.05) -134 -19.2 -(17.60, 20.83) - - - - - - - - - - -134 -18.9 -(17.36, 20.50) -134 -18.8 -(17.15, 20.48) -134 -17.6 -(16.01, 19.28) -134 -17.2 -(15.40, 19.04) -134 -18.0 -(16.32, 19.71) - - - - - - - - - - -132 -19.6 -(18.01, 21.20) -132 -16.5 -(15.14, 17.95) -132 -16.8 -(15.11, 18.40) -132 -17.9 -(16.32, 19.52) -132 -18.5 -(16.89, 20.14) - - - - - - - - - - -C: Combination - - - - - - - - - - -B: Placebo - - - - - - - - - - -A: Drug X - - -Mean 95% CI -Mean -n -Mean 95% CI -Mean -n -Mean 95% CI -Mean -n - - diff --git a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v7.svg b/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v7.svg deleted file mode 100644 index c2713a870b..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-other-mng01/mng01-plot_v7.svg +++ /dev/null @@ -1,149 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -17 -18 -19 -20 -21 - - - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - -A: Drug X (N = 134) -B: Placebo (N = 134) -C: Combination (N = 132) -Laboratory Test: ALT (U/L) -Plot of Mean and 95% Confidence Limits by Visit - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg01/pkcg01-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg01/pkcg01-plot_v1.svg deleted file mode 100644 index cd7e5edb94..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg01/pkcg01-plot_v1.svg +++ /dev/null @@ -1,80 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - -1 -Analyte: Plasma Drug X (ug/mL) -Treatment Group: ARM A -Plot of Plasma Drug X (ug/mL) Concentrations Over Time by -Patient: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg01/pkcg01-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg01/pkcg01-plot_v2.svg deleted file mode 100644 index 36c8f024f8..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg01/pkcg01-plot_v2.svg +++ /dev/null @@ -1,82 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - -1 -Analyte: Plasma Drug X (ug/mL) -Treatment Group: ARM A -Plot of Plasma Drug X (ug/mL) Concentrations Over Time by -Patient: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v1.svg deleted file mode 100644 index e8e520eb99..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v1.svg +++ /dev/null @@ -1,206 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - - - - - - - - - - - - - - - - - - -105 -134 -177 -217 -23 -345 -397 -42 -50 -93 -Analyte: Plasma X (ug/mL) -Treatment Group: ARM A -Plot of X Concentration (ug/mL) Over Time by Treatment: -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v2.svg deleted file mode 100644 index 5f7a8078e0..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v2.svg +++ /dev/null @@ -1,208 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - - - - - - - - - - - - - - - - - - -105 -134 -177 -217 -23 -345 -397 -42 -50 -93 -Analyte: Plasma X (ug/mL) -Treatment Group: ARM A -Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v1.svg deleted file mode 100644 index af6069ed4e..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v1.svg +++ /dev/null @@ -1,154 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Nom. Rel. Time from Analyte First Dose -Concentration (ug/mL) - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X (ug/mL) -Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v2.svg deleted file mode 100644 index 4b9f455ff6..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v2.svg +++ /dev/null @@ -1,156 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Nom. Rel. Time from Analyte First Dose -Concentration (ug/mL) - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X (ug/mL) -Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg deleted file mode 100644 index f5049fbcc2..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg +++ /dev/null @@ -1,82 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -14 -16 -18 - - - - - -12 -24 -Time (hours) -Cummulative Percentage (%) - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X -Visit: CYCLE 1 DAY 1 -PK Parameter: Fe (%) -Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine -by Analyte, Visit: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg deleted file mode 100644 index a2d3676170..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg +++ /dev/null @@ -1,156 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -12 -14 -16 -18 -20 - - - - - - - -12 -24 -Time (hours) -Cummulative Percentage (%) - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -D: Drug D (N = 173) -E: Drug E (N = 138) -F: Drug F (N = 104) -G: Drug G (N = 43) -Analyte: Plasma Drug X -Visit: CYCLE 1 DAY 1 -PK Parameter: Fe (%) -Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine -by Analyte, Visit: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg deleted file mode 100644 index 8249da5b01..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg +++ /dev/null @@ -1,876 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -y = 5.34 - 0.01 x , R² = -0.00113 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 - - - - - - -720 -960 -1200 -480 -1440 -Dose (mg/mL) -AUCinf day*ug/mL - -Treatment Arm - - -A: Drug X (268) -C: Combination (528) -Summary of serum PK parameters by treatment -Dose-Proportionality Plot of Serum A: Drug X AUCinf in day*ug/mL - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg deleted file mode 100644 index f89c5db8cb..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg +++ /dev/null @@ -1,861 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -y = 5.34 - 0.01 x , R² = -0.00113 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 - - - - - - -720 -960 -1200 -480 -1440 -Dose (mg/mL) -AUCinf day*ug/mL - -Treatment Arm - - -A: Drug X (268) -C: Combination (528) -Summary of serum PK parameters by treatment -Dose-Proportionality Plot of Serum A: Drug X AUCinf in day*ug/mL - - diff --git a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg b/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg deleted file mode 100644 index 4cdca4c7ae..0000000000 --- a/package/tests/testthat/_snaps/development/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg +++ /dev/null @@ -1,184 +0,0 @@ - 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- - - - - - - - - - - - -Placebo - -Drug X - - -Baseline Risk Factors -Total n -n -Median (Months) -n -Median (Months) -Hazard Ratio -95% Wald CI -All Patients -268 -134 -NA -134 -NA -1.00 -(0.69, 1.44) -Sex - M -107 -52 -NA -55 -9.6 -1.39 -(0.78, 2.47) - F -161 -82 -NA -79 -NA -0.79 -(0.49, 1.28) -Stratification Factor 1 - C -94 -45 -NA -49 -NA -0.75 -(0.41, 1.38) - B -92 -45 -NA -47 -NA -1.34 -(0.71, 2.54) - A -82 -44 -NA -38 -NA -1.02 -(0.53, 1.97) - -Drug X -Better -Placebo -Better - - - - - - -0.1 -1 -10 - - - - - - - - - - - - - - - - - - - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-fstg02/fstg02-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-fstg02/fstg02-plot_v3.svg deleted file mode 100644 index d3670b9eb9..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-fstg02/fstg02-plot_v3.svg +++ /dev/null @@ -1,88 +0,0 @@ - - - - - - - - - - - - - -Baseline Risk Factors -Total n -Hazard Ratio -90% Wald CI -All Patients -268 -1.00 -(0.74, 1.36) -Sex - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -N - - - - -134 - - - - -ARM A - - - - -Median - - - - -134 - - - - -ARM B - - - - -95% CI - - - - -132 - - - - -ARM C - - - - -NA - - - - -NA - - - - -286.6 - - - - -(283.1, NA) - - - - -(287.3, NA) - - - - -(232.1, NA) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -HR - - - - -1.00 - - - - -ARM B - - - - -95% CI - - - - -1.29 - - - - -ARM C - - - - -p-value (log-rank) - - - - -(0.69, 1.44) - - - - -(0.91, 1.83) - - - - -0.9998 - - - - -0.1541 - - -0.00 -0.25 -0.50 -0.75 -1.00 - - - - - -Survival Probability - - - - - - -0 -100 -200 -300 -400 -500 -Time (Days) - - - - -ARM A -ARM B -ARM C -Patients at Risk: - - - -134 -121 -93 -76 -37 -0 -134 -124 -91 -76 -31 -0 -132 -116 -89 -63 -29 -0 - - - -ARM A -ARM B -ARM C - - - - - - -0 -100 -200 -300 -400 -500 -Time (Days) - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-kmg01/kmg01-plot_v5.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-kmg01/kmg01-plot_v5.svg deleted file mode 100644 index 6036b4b5f4..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-kmg01/kmg01-plot_v5.svg +++ /dev/null @@ -1,752 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -N - - - - -134 - - - - -ARM A - - - - -Median - - - - -134 - - - - -ARM B - - - - -95% CI - - - - -132 - - - - -ARM C - - - - -NA - - - - -NA - - - - -286.6 - - - - -(283.1, NA) - - - - -(287.3, NA) - - - - -(232.1, NA) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -HR - - - - -1.00 - - - - -ARM B - - - - -95% CI - - - - -1.29 - - - - -ARM C - - - - -p-value (log-rank) - - - - -(0.69, 1.44) - - - - -(0.91, 1.83) - - - - -0.9998 - - - - -0.1541 - - -0.00 -0.25 -0.50 -0.75 -1.00 - - - - - -Survival Probability - - - - - - -0 -100 -200 -300 -400 -500 -Time (Days) - - - - -ARM A -ARM B -ARM C - -Censored -Patients at Risk: - - - -134 -121 -93 -76 -37 -0 -134 -124 -91 -76 -31 -0 -132 -116 -89 -63 -29 -0 - - - -ARM A -ARM B -ARM C - - - - - - -0 -100 -200 -300 -400 -500 -Time (Days) - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-kmg01/kmg01-plot_v6.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-kmg01/kmg01-plot_v6.svg deleted file mode 100644 index 4567368101..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-kmg01/kmg01-plot_v6.svg +++ /dev/null @@ -1,968 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -N - - - - -134 - - - - -ARM A - - - - -Median - - - - -134 - - - - -ARM B - - - - -80% CI - - - - -132 - - - - -ARM C - - - - -NA - - - - -NA - - - - -286.6 - - - - -(NA, NA) - - - - -(NA, NA) - - - - -(246.5, NA) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -HR - - - - -1.00 - - - - -ARM B - - - - -80% CI - - - - -1.26 - - - - -ARM C - - - - -p-value (wald) - - - - -(0.78, 1.27) - - - - -(1.00, 1.59) - - - - -0.986 - - - - -0.2032 - - -0.00 -0.25 -0.50 -0.75 -1.00 - - - - - -Survival Probability - - - - - - -0 -100 -200 -300 -400 -500 -Time (Days) - - - - -ARM A -ARM B -ARM C - - -Censored -Patients at Risk: - - - -134 -121 -93 -76 -37 -0 -134 -124 -91 -76 -31 -0 -132 -116 -89 -63 -29 -0 - - - -ARM A -ARM B -ARM C - - - - - - -0 -100 -200 -300 -400 -500 -Time (Days) - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v1.svg deleted file mode 100644 index 73104aabd5..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v1.svg +++ /dev/null @@ -1,166 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Adjusted mean of Analysis Value by treatment at visits - - - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -50 -60 -70 - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - -B: Placebo -A: Drug X -C: Combination - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v2.svg deleted file mode 100644 index e36bc07157..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v2.svg +++ /dev/null @@ -1,172 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Adjusted mean of Analysis Value by treatment at visits - - - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -50 -60 -70 - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - - - - -B: Placebo -A: Drug X -C: Combination - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v3.svg deleted file mode 100644 index 21094b6aad..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v3.svg +++ /dev/null @@ -1,332 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Adjusted mean of Analysis Value by treatment at visits - - - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -50 -60 -70 - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - -B: Placebo -A: Drug X -C: Combination - - - - - - - - - - - - - - - - - - -134 -45.2 -0.7 -(43.78, 46.68) -134 -54.3 -0.7 -(52.99, 55.71) -134 -60.0 -0.8 -(58.49, 61.50) -134 -64.4 -0.9 -(62.71, 66.11) -134 -69.0 -1.0 -(67.01, 70.92) -134 -74.4 -1.1 -(72.29, 76.44) - - - - - - - - - - -134 -44.6 -0.7 -(43.12, 46.02) -134 -55.0 -0.7 -(53.66, 56.38) -134 -59.8 -0.8 -(58.29, 61.30) -134 -66.8 -0.9 -(65.09, 68.49) -134 -70.3 -1.0 -(68.30, 72.21) -134 -75.7 -1.1 -(73.63, 77.78) - - - - - - - - - - -132 -44.7 -0.7 -(43.24, 46.16) -132 -53.9 -0.7 -(52.57, 55.31) -132 -59.3 -0.8 -(57.77, 60.80) -132 -66.6 -0.9 -(64.85, 68.28) -132 -70.3 -1.0 -(68.32, 72.26) -132 -74.5 -1.1 -(72.39, 76.58) - - - - - - - - - - -C: Combination - - - - - - - - - - -A: Drug X - - - - - - - - - - -B: Placebo - - -95% CI -Std. Error -LS mean -n -95% CI -Std. Error -LS mean -n -95% CI -Std. Error -LS mean -n - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v4.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v4.svg deleted file mode 100644 index 63aaf983f7..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v4.svg +++ /dev/null @@ -1,137 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.5235 -0.6112 -0.4924 -0.6772 -0.8504 -0.5140 -0.0528 -0.0800 -0.3593 -0.3480 -0.3704 -0.9378 - -Contrasts of FKSI-FWB means - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 --2.5 -0.0 -2.5 -5.0 - - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - -B: Placebo -A: Drug X -C: Combination - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v5.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v5.svg deleted file mode 100644 index 0200efaede..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v5.svg +++ /dev/null @@ -1,2740 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING - - - - - - - - - - -WEEK 1 DAY 8 - - - - - - - - - - -WEEK 2 DAY 15 - - - - - - - - - - -WEEK 3 DAY 22 - - - - - - - - - - -WEEK 4 DAY 29 - - - - - - - - - - -WEEK 5 DAY 36 - - - - - - -44.6 -44.8 -45.0 -45.2 - - - - -54.0 -54.3 -54.6 -54.9 - - - - - -59.2 -59.4 -59.6 -59.8 -60.0 - - -65 -66 - - - - -69.2 -69.6 -70.0 -70.4 - - - -74.5 -75.0 -75.5 --40 --20 -0 -20 -40 - - - - - -Fitted values -Residuals - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v6.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v6.svg deleted file mode 100644 index c1dbba5a11..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg01/mmrmg01-plot_v6.svg +++ /dev/null @@ -1,2686 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING - - - - - - - - - - -WEEK 1 DAY 8 - - - - - - - - - - -WEEK 2 DAY 15 - - - - - - - - - - -WEEK 3 DAY 22 - - - - - - - - - - -WEEK 4 DAY 29 - - - - - - - - - - -WEEK 5 DAY 36 - - - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 - - - --2 -0 -2 --2 -0 -2 - - - -Standard normal quantiles -Standardized residuals - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg02/mmrmg02-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg02/mmrmg02-plot_v1.svg deleted file mode 100644 index 201328de65..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg02/mmrmg02-plot_v1.svg +++ /dev/null @@ -1,88 +0,0 @@ - - - - - - - - - - - - -Baseline Risk Factors -Total n -Mean Difference -95% CI -p-value -All Patients -393 --1.3 -(-3.3, 0.6) -0.1813 -group - subpopulation 1 -125 --0.5 -(-3.4, 2.4) -0.7380 - subpopulation 2 -268 --1.1 -(-3.2, 0.9) -0.2798 -SEX - F -240 --1.4 -(-4.0, 1.2) -0.2918 - M -153 --1.2 -(-4.1, 1.7) -0.4276 - -ARM B -Higher -ARM A -Higher - - - - - - - --5 --2.5 -0 -2.5 - - - - - - - - - - - - - - - - - diff --git a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg02/mmrmg02-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg02/mmrmg02-plot_v2.svg deleted file mode 100644 index df9c048bab..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-efficacy-mmrmg02/mmrmg02-plot_v2.svg +++ /dev/null @@ -1,88 +0,0 @@ - - - - - - - - - - - - -Baseline Risk Factors -Total n -Mean Difference -95% CI -p-value -All Patients -383 --1.4 -(-3.3, 0.6) -0.1659 -group - subpopulation 1 -117 --1.6 -(-4.7, 1.4) -0.2921 - subpopulation 2 -266 --1.0 -(-3.1, 1.1) -0.3605 -SEX - F -217 --2.2 -(-4.9, 0.5) -0.1156 - M -166 --0.4 -(-3.2, 2.4) -0.7911 - -ARM B -Higher -ARM C -Higher - - - - - - - --5 --2.5 -0 -2.5 - - - - - - - - - - - - - - - - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v1.svg deleted file mode 100644 index ca0f848442..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v1.svg +++ /dev/null @@ -1,73 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -104 -101 -99 - - -0 -25 -50 -75 -100 - - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Frequency -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v2.svg deleted file mode 100644 index bdf6552120..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v2.svg +++ /dev/null @@ -1,74 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -19.5 -18.75 -22.25 - - -0 -5 -10 -15 -20 - - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent -Percent of Subjects With cl A Disorders: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v3.svg deleted file mode 100644 index ad6a07ecf3..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v3.svg +++ /dev/null @@ -1,73 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -25 -50 -75 - - - - - - - -A: Drug X - -N = 78 -B: Placebo - -N = 75 -C: Combination - -N = 89 -Description of Actual Arm (N = 400) -Frequency -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v4.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v4.svg deleted file mode 100644 index 5efbd0d7df..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v4.svg +++ /dev/null @@ -1,70 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X -B: Placebo -C: Combination - - - - - - - - -0 -25 -50 -75 -100 -Frequency -Description of Actual Arm (N = 400) -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v5.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v5.svg deleted file mode 100644 index 8295c9cfad..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v5.svg +++ /dev/null @@ -1,72 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -1 -2 - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percentage -Percent of Subjects with Abnormaly High ALT: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v6.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v6.svg deleted file mode 100644 index 670472b2d2..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v6.svg +++ /dev/null @@ -1,81 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 -60 -80 - - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent - -Sex - - - - -F -M -Percent of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v7.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v7.svg deleted file mode 100644 index 1345c011c3..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v7.svg +++ /dev/null @@ -1,77 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - -F -M -Sex (N = 400) -Percent - -Description of Actual Arm - - - - - - -A: Drug X -B: Placebo -C: Combination -Percent of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v8.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v8.svg deleted file mode 100644 index 730afb7fe6..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v8.svg +++ /dev/null @@ -1,107 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 -5.5 -4.25 - - -0 -2 -4 -6 - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent -Percent of Subjects with Abnormaly High CRP at Baseline - Safety-Evaluable Subjects - - - - - - - - - - - - - - - - - - -10.45 -10.34 -10.46 -10.23 -10.25 -10.33 - - -Median -Mean - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v9.svg b/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v9.svg deleted file mode 100644 index 5e0b71f5e1..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-brg01/brg01-plot_v9.svg +++ /dev/null @@ -1,96 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent - -Analysis Toxicity Grade (C) - - - - - - - - - - -1 -2 -3 -4 -5 -Percent of Subjects With AE by Highest - NCI CTCAE Grade: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v1.svg deleted file mode 100644 index cb0dc6a311..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v1.svg +++ /dev/null @@ -1,100 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v2.svg deleted file mode 100644 index 4f89a62643..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v2.svg +++ /dev/null @@ -1,93 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -10 -20 -30 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the 5th and 95th percentile. Values outside the whiskers have not been plotted. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v3.svg deleted file mode 100644 index fc2fe5785e..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v3.svg +++ /dev/null @@ -1,142 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the 5th and 95th percentile. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v4.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v4.svg deleted file mode 100644 index 0181b96e88..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v4.svg +++ /dev/null @@ -1,124 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -141 -64 -256 -102 -154 -309 -264 -68 -70 -4 -203 -44 - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the largest and smallest observed value within 1.5*IQR. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v5.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v5.svg deleted file mode 100644 index 45f3f071f0..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v5.svg +++ /dev/null @@ -1,91 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v6.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v6.svg deleted file mode 100644 index 542f77546b..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v6.svg +++ /dev/null @@ -1,216 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -Visit -ALT (U/L) - -ARMCD - - - - - - - - - - - - - - - -ARM A -ARM B -ARM C -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v7.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v7.svg deleted file mode 100644 index bcaf35ff73..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v7.svg +++ /dev/null @@ -1,219 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -AVISIT - - - - - - - - - - - - - - - - - - - - -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -Box Plot of Laboratory Test Results -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v8.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v8.svg deleted file mode 100644 index 6cbf07fdd1..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v8.svg +++ /dev/null @@ -1,145 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: SCREENING -Box Plot of Laboratory Test Results - - - - - - - - - - - - - - - - - - -2814 -2814 -2772 -10 -10.1 -10 -8.6 -8.5 -8.6 -8.6 - 8.4 -8.5 - 8.4 -8.6 - 8.5 -3 - 11.3 -3 - 11.6 -3 - 11.8 -0-54.24 -0-54.4 -0-44.75 - - -Min - Max -25% and 75%-ile -95% CI for Median -Median -Mean -n -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v9.svg b/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v9.svg deleted file mode 100644 index 18c0328aa8..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-bwg01/bwg01-plot_v9.svg +++ /dev/null @@ -1,125 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -20 -40 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: SCREENING -Box Plot of Laboratory Test Results - - - - - - - - - - - - - - - - - - -2814 -2814 -2772 - - -n -The whiskers extend to the minimum and maximum values. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v1_and_v2.svg b/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v1_and_v2.svg deleted file mode 100644 index 3bd68d30c8..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v1_and_v2.svg +++ /dev/null @@ -1,103 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -14 -16 -18 -20 -22 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -SEX - - - - - - -F -M -Confidence Interval Plot by Treatment Group -Mean and 95% CIs for mean are displayed. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v3.svg deleted file mode 100644 index 38d5dabf66..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v3.svg +++ /dev/null @@ -1,99 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -16 -18 -20 -22 - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -STRATA2 - - - - - - -S1 -S2 -Confidence Interval Plot by Treatment Group -Mean and 95% CIs for mean are displayed. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v4.svg b/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v4.svg deleted file mode 100644 index 46b4efddde..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v4.svg +++ /dev/null @@ -1,111 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -15 -20 -25 - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -STRATA1 - - - - - - - - - -A -B -C -Confidence Interval Plot by Treatment Group -Median and 95% CIs for median are displayed. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v5.svg b/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v5.svg deleted file mode 100644 index f75426473e..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-cig01/cig01-plot_v5.svg +++ /dev/null @@ -1,98 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -15.0 -17.5 -20.0 -22.5 - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) - -SEX - - - - - - -F -M -Confidence Interval Plot by Treatment Group -Mean and 90% CIs for mean are displayed. - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v1.svg deleted file mode 100644 index 39e0a4db84..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v1.svg +++ /dev/null @@ -1,754 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X - - - - - - - - - - -B: Placebo - - - - - - - - - - -C: Combination - - - - - - - - - - -ALT - - - - - - - - - - -CRP - - - - - - - - - - -IGA - - - - - -2 -4 -6 - - - -2 -4 -6 - - - -2 -4 -6 -0 -10 -20 -30 - - - - -7 -8 -9 -10 -11 - - - - - -2.7 -2.8 -2.9 -3.0 -3.1 - - - - - -AVISIT -AVAL - -SUBJID - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-128 -id-201 -id-220 -id-261 -id-262 -id-267 -id-378 -id-45 - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v2.svg deleted file mode 100644 index 62e0475651..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v2.svg +++ /dev/null @@ -1,757 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X (N = 2) - - - - - - - - - - -B: Placebo (N = 3) - - - - - - - - - - -C: Combination (N = 3) - - - - - - - - - - -ALT -(U/L) - - - - - - - - - - -CRP -(mg/L) - - - - - - - - - - -IGA -(g/L) - - - - - -2 -4 -6 - - - -2 -4 -6 - - - -2 -4 -6 -0 -10 -20 -30 - - - - -7 -8 -9 -10 -11 - - - - - -2.7 -2.8 -2.9 -3.0 -3.1 - - - - - -AVISIT -AVAL - -SUBJID - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-128 -id-201 -id-220 -id-261 -id-262 -id-267 -id-378 -id-45 - - diff --git a/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v3.svg deleted file mode 100644 index 21db41dbe7..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-other-ltg01/ltg01-plot_v3.svg +++ /dev/null @@ -1,3248 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X (N = 2) - - - - - - - - - - -B: Placebo (N = 3) - - - - - - - - - - -C: Combination (N = 3) - - - - - - - - - - -ALT -(U/L) - - - - - - - - - - -CRP -(mg/L) - - - - - - - - - - -IGA -(g/L) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 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DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE 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4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 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-Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - -1 -Analyte: Plasma Drug X (ug/mL) -Treatment Group: ARM A -Plot of Plasma Drug X (ug/mL) Concentrations Over Time by -Patient: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v1.svg deleted file mode 100644 index e8e520eb99..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v1.svg +++ /dev/null @@ -1,206 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - - - - - - - - - - - - - - - - - - -105 -134 -177 -217 -23 -345 -397 -42 -50 -93 -Analyte: Plasma X (ug/mL) -Treatment Group: ARM A -Plot of X Concentration (ug/mL) Over Time by Treatment: -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v2.svg deleted file mode 100644 index 5f7a8078e0..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg02/pkcg02-plot_v2.svg +++ /dev/null @@ -1,208 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - - - - - - - - - - - - - - - - - - -105 -134 -177 -217 -23 -345 -397 -42 -50 -93 -Analyte: Plasma X (ug/mL) -Treatment Group: ARM A -Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v1.svg deleted file mode 100644 index af6069ed4e..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v1.svg +++ /dev/null @@ -1,154 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Nom. Rel. Time from Analyte First Dose -Concentration (ug/mL) - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X (ug/mL) -Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v2.svg deleted file mode 100644 index 4b9f455ff6..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkcg03/pkcg03-plot_v2.svg +++ /dev/null @@ -1,156 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Nom. Rel. Time from Analyte First Dose -Concentration (ug/mL) - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X (ug/mL) -Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg deleted file mode 100644 index f5049fbcc2..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v1.svg +++ /dev/null @@ -1,82 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -14 -16 -18 - - - - - -12 -24 -Time (hours) -Cummulative Percentage (%) - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X -Visit: CYCLE 1 DAY 1 -PK Parameter: Fe (%) -Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine -by Analyte, Visit: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg deleted file mode 100644 index a2d3676170..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg01/pkpg01-plot_v2.svg +++ /dev/null @@ -1,156 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -12 -14 -16 -18 -20 - - - - - - - -12 -24 -Time (hours) -Cummulative Percentage (%) - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -D: Drug D (N = 173) -E: Drug E (N = 138) -F: Drug F (N = 104) -G: Drug G (N = 43) -Analyte: Plasma Drug X -Visit: CYCLE 1 DAY 1 -PK Parameter: Fe (%) -Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine -by Analyte, Visit: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg deleted file mode 100644 index 8249da5b01..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v1.svg +++ /dev/null @@ -1,876 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -y = 5.34 - 0.01 x , R² = -0.00113 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 - - - - - - -720 -960 -1200 -480 -1440 -Dose (mg/mL) -AUCinf day*ug/mL - -Treatment Arm - - -A: Drug X (268) -C: Combination (528) -Summary of serum PK parameters by treatment -Dose-Proportionality Plot of Serum A: Drug X AUCinf in day*ug/mL - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg deleted file mode 100644 index f89c5db8cb..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg02/pkpg02-plot_v2.svg +++ /dev/null @@ -1,861 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -y = 5.34 - 0.01 x , R² = -0.00113 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 - - - - - - -720 -960 -1200 -480 -1440 -Dose (mg/mL) -AUCinf day*ug/mL - -Treatment Arm - - -A: Drug X (268) -C: Combination (528) -Summary of serum PK parameters by treatment -Dose-Proportionality Plot of Serum A: Drug X AUCinf in day*ug/mL - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg deleted file mode 100644 index 4cdca4c7ae..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg03/pkpg03-plot_v1.svg +++ /dev/null @@ -1,184 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-53 -id-360 -id-10 -id-104 -id-78 -id-224 -id-324 -id-104 -id-140 -id-187 -id-195 -id-99 -id-378 -id-215 -id-245 -id-64 -id-363 -id-181 - - - -10 -20 -30 -40 -50 - - - - - - - - -SCREENING -CYCLE 1 DAY 1 -CYCLE 1 DAY 2 -Visit -Max Conc (ug/mL) - -ACTARM - - - - - - - - -a - - - - - - - - -a -A: Drug X -C: Combination -Analyte: -PK Parameter: Max Conc (ug/mL) -Boxplot of Max Conc by Visit -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg04/pkpg04-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg04/pkpg04-plot_v1.svg deleted file mode 100644 index f412cf9b26..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg04/pkpg04-plot_v1.svg +++ /dev/null @@ -1,2575 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-53 -id-360 -id-10 -id-104 -id-78 -id-224 -id-324 -id-104 -id-140 -id-187 -id-195 -id-99 -id-378 -id-215 -id-245 -id-64 -id-363 -id-181 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -10 -20 -30 -40 -50 - - - - - - - - -SCREENING -CYCLE 1 DAY 1 -CYCLE 1 DAY 2 -Visit -Max Conc (ug/mL) - -ACTARM - - - - - - - - -a - - - - - - - - - -a - -A: Drug X -C: Combination -Analyte: -PK Parameter: Max Conc (ug/mL) -Boxplot of Max Conc by Visit -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v1.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v1.svg deleted file mode 100644 index 343e9e4a4f..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v1.svg +++ /dev/null @@ -1,142 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -AB12345-PAK-11-id-268 -AB12345-CHN-14-id-1 -AB12345-PAK-11-id-49 -AB12345-CHN-3-id-303 -AB12345-BRA-1-id-93 -AB12345-CHN-1-id-389 -AB12345-CHN-1-id-25 -AB12345-CHN-15-id-262 -AB12345-CHN-15-id-297 -AB12345-PAK-11-id-49 -AB12345-CHN-1-id-279 -AB12345-CHN-17-id-10 -AB12345-CHN-11-id-113 - - - -1 -2 - - - - -AUCIFO -CMAX -Parameter -Metabolite to Parent Ratio - -ACTARM - - - - - - - - - - - - - - - - -A: Drug X -C: Combination -Analyte: Plasma Drug X, Metabolite Drug X -PK Parameter: AUCIFO, CMAX -Visit: CYCLE 1 DAY 1 -Boxplot of Metabolite to Parent Ratios by Treatment -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v2.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v2.svg deleted file mode 100644 index 63cd8130ca..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v2.svg +++ /dev/null @@ -1,95 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -AB12345-CHN-15-id-201 -AB12345-PAK-4-id-15 -AB12345-CHN-15-id-297 - - - -0.5 -1.0 -1.5 -2.0 - - - - - - -AUCIFO -CMAX -Parameter -Metabolite to Parent Ratio - -ACTARM - - - - - - - - -C: Combination -Analyte: Plasma Drug Y, Metabolite Drug Y -PK Parameter: AUCIFO, CMAX -Visit: CYCLE 1 DAY 1 -Boxplot of Metabolite to Parent Ratios by Treatment -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v3.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v3.svg deleted file mode 100644 index dbfd87691a..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v3.svg +++ /dev/null @@ -1,129 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -1 -2 - - - - -AUCIFO -CMAX -Parameter -Metabolite to Parent Ratio - -ACTARM - - - - - - - - - - - - - - - - -A: Drug X -C: Combination -Analyte: Plasma Drug X, Metabolite Drug X -PK Parameter: AUCIFO, CMAX -Visit: CYCLE 1 DAY 1 -Boxplot of Metabolite to Parent Ratios by Treatment -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v4.svg b/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v4.svg deleted file mode 100644 index 95b880d95d..0000000000 --- a/package/tests/testthat/_snaps/stable/graphs-pharmacokinetic-pkpg06/pkpg06-plot_v4.svg +++ /dev/null @@ -1,228 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -AB12345-PAK-11-id-268 -AB12345-CHN-11-id-263 -AB12345-CHN-14-id-1 -AB12345-CHN-5-id-160 -AB12345-CHN-4-id-114 -AB12345-PAK-12-id-328 -AB12345-CHN-15-id-297 -AB12345-CHN-11-id-392 -AB12345-CHN-5-id-83 -AB12345-JPN-1-id-7 -AB12345-CHN-14-id-228 -AB12345-BRA-14-id-23 -AB12345-JPN-1-id-225 -AB12345-PAK-11-id-49 -AB12345-CHN-3-id-303 -AB12345-CHN-11-id-256 -AB12345-CHN-14-id-375 -AB12345-NGA-1-id-46 -AB12345-CHN-1-id-181 -AB12345-BRA-1-id-93 -AB12345-CHN-1-id-389 -AB12345-RUS-11-id-283 -AB12345-NGA-11-id-41 -AB12345-CHN-14-id-143 -AB12345-BRA-14-id-120 -AB12345-JPN-5-id-252 -AB12345-CHN-1-id-25 -AB12345-RUS-6-id-77 -AB12345-CHN-15-id-262 -AB12345-RUS-1-id-52 -AB12345-BRA-11-id-50 -AB12345-CAN-14-id-104 -AB12345-USA-3-id-320 -AB12345-PAK-12-id-328 -AB12345-CHN-15-id-297 -AB12345-BRA-11-id-217 -AB12345-CHN-12-id-57 -AB12345-CHN-15-id-399 -AB12345-PAK-11-id-49 -AB12345-CHN-11-id-192 -AB12345-CHN-11-id-377 -AB12345-CHN-1-id-279 -AB12345-CHN-12-id-255 -AB12345-USA-12-id-140 -AB12345-CHN-11-id-2 -AB12345-RUS-11-id-283 -AB12345-PAK-12-id-85 -AB12345-CHN-1-id-25 -AB12345-PAK-1-id-125 -AB12345-CHN-11-id-349 -AB12345-USA-11-id-224 -AB12345-CHN-17-id-10 -AB12345-CHN-1-id-71 -AB12345-JPN-6-id-260 -AB12345-CHN-11-id-113 -AB12345-CHN-1-id-277 - - - -1 -2 - - - - -AUCIFO -CMAX -Parameter -Metabolite to Parent Ratio - -ACTARM - - - - - - - - - - - - - - - - -A: Drug X -C: Combination -Analyte: Plasma Drug X, Metabolite Drug X -PK Parameter: AUCIFO, CMAX -Visit: CYCLE 1 DAY 1 -Boxplot of Metabolite to Parent Ratios by Treatment -Program: -Output: - - From cae9864948e7a31d84206090793c7180924879b7 Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Wed, 12 Jun 2024 19:07:04 +0200 Subject: [PATCH 4/7] install devel deps for devel profile --- .github/workflows/check.yml | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/.github/workflows/check.yml b/.github/workflows/check.yml index ff02d81473..1a83975a67 100644 --- a/.github/workflows/check.yml +++ b/.github/workflows/check.yml @@ -27,6 +27,7 @@ jobs: secrets: REPO_GITHUB_TOKEN: ${{ secrets.REPO_GITHUB_TOKEN }} with: + install-deps-from-package-repositories: "R-universe=https://pharmaverse.r-universe.dev/,CRAN=https://cloud.r-project.org/" package-subdirectory: package additional-env-vars: | _R_CHECK_CRAN_INCOMING_REMOTE_=false @@ -43,7 +44,7 @@ jobs: package-subdirectory: package additional-env-vars: | _R_CHECK_CRAN_INCOMING_REMOTE_=false - QUARTO_PROFILE=stable + QUARTO_PROFILE=stable concurrency-group: stable linter: if: github.event_name != 'push' From 2a27831a958e261e38cbfa4585002413242b031e Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Thu, 13 Jun 2024 11:52:20 +0200 Subject: [PATCH 5/7] fix path of urlchecker workflow --- .github/workflows/check.yml | 2 ++ 1 file changed, 2 insertions(+) diff --git a/.github/workflows/check.yml b/.github/workflows/check.yml index 1a83975a67..c582f6311f 100644 --- a/.github/workflows/check.yml +++ b/.github/workflows/check.yml @@ -54,6 +54,8 @@ jobs: if: github.event_name != 'push' name: Check URLs 🌐 uses: insightsengineering/r.pkg.template/.github/workflows/links.yaml@main + with: + package-subdirectory: package vbump: name: Version Bump 🤜🤛 if: github.event_name == 'push' From 4efab49d9772885bc7172bb3ae95ea00de4f5c5a Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Thu, 13 Jun 2024 15:43:22 +0200 Subject: [PATCH 6/7] add NOT_CRAN=true --- .github/workflows/check.yml | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/.github/workflows/check.yml b/.github/workflows/check.yml index c582f6311f..bf47198a4c 100644 --- a/.github/workflows/check.yml +++ b/.github/workflows/check.yml @@ -30,7 +30,7 @@ jobs: install-deps-from-package-repositories: "R-universe=https://pharmaverse.r-universe.dev/,CRAN=https://cloud.r-project.org/" package-subdirectory: package additional-env-vars: | - _R_CHECK_CRAN_INCOMING_REMOTE_=false + NOT_CRAN=true QUARTO_PROFILE=development concurrency-group: development r-cmd-stable: @@ -43,7 +43,7 @@ jobs: install-deps-from-package-repositories: "R-universe=https://insightsengineering.r-universe.dev/,CRAN=https://cloud.r-project.org/" package-subdirectory: package additional-env-vars: | - _R_CHECK_CRAN_INCOMING_REMOTE_=false + NOT_CRAN=true QUARTO_PROFILE=stable concurrency-group: stable linter: From 3eb378cc1b21d0cb100418f9320af18090c16bc3 Mon Sep 17 00:00:00 2001 From: Pawel Rucki <12943682+pawelru@users.noreply.github.com> Date: Thu, 13 Jun 2024 16:34:24 +0200 Subject: [PATCH 7/7] copy values from CI results --- .../development/tables-efficacy-rbmit01.md | 36 +++++++++---------- .../_snaps/stable/tables-efficacy-rbmit01.md | 36 +++++++++---------- 2 files changed, 36 insertions(+), 36 deletions(-) diff --git a/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md b/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md index cf4408adc8..22d838ab26 100644 --- a/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md +++ b/package/tests/testthat/_snaps/development/tables-efficacy-rbmit01.md @@ -13,24 +13,24 @@ Relative Reduction (%) 5.7% p-value (RBMI) 0.8932 5 - Adjusted Mean (SE) -4.253 (0.651) -2.812 (0.645) - 95% CI (-5.539, -2.968) (-4.087, -1.537) - Difference in Adjusted Means (SE) 1.442 (0.921) - 95% CI (-0.377, 3.261) - Relative Reduction (%) -33.9% - p-value (RBMI) 0.1195 + Adjusted Mean (SE) -4.251 (0.647) -2.805 (0.644) + 95% CI (-5.528, -2.974) (-4.077, -1.533) + Difference in Adjusted Means (SE) 1.446 (0.914) + 95% CI (-0.358, 3.250) + Relative Reduction (%) -34.0% + p-value (RBMI) 0.1155 6 - Adjusted Mean (SE) -6.359 (0.724) -4.126 (0.696) - 95% CI (-7.791, -4.927) (-5.502, -2.749) - Difference in Adjusted Means (SE) 2.234 (1.000) - 95% CI (0.258, 4.210) - Relative Reduction (%) -35.1% - p-value (RBMI) 0.0270 + Adjusted Mean (SE) -6.366 (0.721) -4.095 (0.696) + 95% CI (-7.793, -4.939) (-5.471, -2.720) + Difference in Adjusted Means (SE) 2.270 (0.996) + 95% CI (0.301, 4.239) + Relative Reduction (%) -35.7% + p-value (RBMI) 0.0241 7 - Adjusted Mean (SE) -7.612 (0.822) -4.819 (0.767) - 95% CI (-9.242, -5.982) (-6.335, -3.302) - Difference in Adjusted Means (SE) 2.793 (1.110) - 95% CI (0.597, 4.989) - Relative Reduction (%) -36.7% - p-value (RBMI) 0.0131 + Adjusted Mean (SE) -7.689 (0.797) -4.776 (0.752) + 95% CI (-9.266, -6.112) (-6.261, -3.290) + Difference in Adjusted Means (SE) 2.913 (1.073) + 95% CI (0.792, 5.035) + Relative Reduction (%) -37.9% + p-value (RBMI) 0.0074 diff --git a/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md b/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md index 7e93ad6359..d51404e2af 100644 --- a/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md +++ b/package/tests/testthat/_snaps/stable/tables-efficacy-rbmit01.md @@ -13,24 +13,24 @@ Relative Reduction (%) 5.7% p-value (RBMI) 0.8932 5 - Adjusted Mean (SE) -4.256 (0.649) -2.822 (0.646) - 95% CI (-5.538, -2.974) (-4.098, -1.545) - Difference in Adjusted Means (SE) 1.434 (0.920) - 95% CI (-0.383, 3.252) - Relative Reduction (%) -33.7% - p-value (RBMI) 0.1211 + Adjusted Mean (SE) -4.251 (0.647) -2.805 (0.644) + 95% CI (-5.528, -2.974) (-4.077, -1.533) + Difference in Adjusted Means (SE) 1.446 (0.914) + 95% CI (-0.358, 3.250) + Relative Reduction (%) -34.0% + p-value (RBMI) 0.1155 6 - Adjusted Mean (SE) -6.373 (0.716) -4.164 (0.689) - 95% CI (-7.789, -4.956) (-5.524, -2.803) - Difference in Adjusted Means (SE) 2.209 (0.990) - 95% CI (0.253, 4.165) - Relative Reduction (%) -34.7% - p-value (RBMI) 0.0271 + Adjusted Mean (SE) -6.366 (0.721) -4.095 (0.696) + 95% CI (-7.793, -4.939) (-5.471, -2.720) + Difference in Adjusted Means (SE) 2.270 (0.996) + 95% CI (0.301, 4.239) + Relative Reduction (%) -35.7% + p-value (RBMI) 0.0241 7 - Adjusted Mean (SE) -7.640 (0.822) -4.823 (0.767) - 95% CI (-9.270, -6.010) (-6.341, -3.306) - Difference in Adjusted Means (SE) 2.816 (1.103) - 95% CI (0.634, 4.999) - Relative Reduction (%) -36.9% - p-value (RBMI) 0.0118 + Adjusted Mean (SE) -7.689 (0.797) -4.776 (0.752) + 95% CI (-9.266, -6.112) (-6.261, -3.290) + Difference in Adjusted Means (SE) 2.913 (1.073) + 95% CI (0.792, 5.035) + Relative Reduction (%) -37.9% + p-value (RBMI) 0.0074