diff --git a/main/404.html b/main/404.html
index 70ec5a67..514382f0 100644
--- a/main/404.html
+++ b/main/404.html
@@ -25,7 +25,7 @@
     
     <a class="navbar-brand me-2" href="https://insightsengineering.github.io/teal.modules.hermes/index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -43,16 +43,6 @@
 <li class="nav-item">
   <a class="nav-link" href="https://insightsengineering.github.io/teal.modules.hermes/news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off">
diff --git a/main/CODE_OF_CONDUCT.html b/main/CODE_OF_CONDUCT.html
index 486f7b3b..f9f3fe82 100644
--- a/main/CODE_OF_CONDUCT.html
+++ b/main/CODE_OF_CONDUCT.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="nav-item">
   <a class="nav-link" href="news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/CONTRIBUTING.html b/main/CONTRIBUTING.html
index e0d8d67e..20be5293 100644
--- a/main/CONTRIBUTING.html
+++ b/main/CONTRIBUTING.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="nav-item">
   <a class="nav-link" href="news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/LICENSE-text.html b/main/LICENSE-text.html
index 0f6c4df5..98289abf 100644
--- a/main/LICENSE-text.html
+++ b/main/LICENSE-text.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="nav-item">
   <a class="nav-link" href="news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/SECURITY.html b/main/SECURITY.html
index 1eca94b7..17293834 100644
--- a/main/SECURITY.html
+++ b/main/SECURITY.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="nav-item">
   <a class="nav-link" href="news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/articles/Getting_Started.html b/main/articles/Getting_Started.html
index a538a9cb..0b51271f 100644
--- a/main/articles/Getting_Started.html
+++ b/main/articles/Getting_Started.html
@@ -27,7 +27,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -45,16 +45,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off">
diff --git a/main/articles/index.html b/main/articles/index.html
index d5c34e20..11c6bdd5 100644
--- a/main/articles/index.html
+++ b/main/articles/index.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/authors.html b/main/authors.html
index 3c96c195..efb5a3e9 100644
--- a/main/authors.html
+++ b/main/authors.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="nav-item">
   <a class="nav-link" href="news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
@@ -135,14 +125,14 @@ <h2 id="citation">Citation</h2>
 
       <p>Sabanés Bové D, Burkoff N, Kulkarni D, Pagacz K, Bhatia N, Kaledkowski D, Rucki P, Luong J, Bienert S, Li H, Zhang L (2024).
 <em>teal.modules.hermes: RNA-Seq Analysis Modules to Add to a Teal Application</em>.
-R package version 0.1.6.9009, 
+R package version 0.1.6.9010, 
 https://github.com/insightsengineering/teal.modules.hermes/, <a href="https://insightsengineering.github.io/teal.modules.hermes/">https://insightsengineering.github.io/teal.modules.hermes/</a>. 
 </p>
       <pre>@Manual{,
   title = {teal.modules.hermes: RNA-Seq Analysis Modules to Add to a Teal Application},
   author = {Daniel {Sabanés Bové} and Nikolas Burkoff and Dinakar Kulkarni and Konrad Pagacz and Namrata Bhatia and Dawid Kaledkowski and Pawel Rucki and Jeff Luong and Stefanie Bienert and Haocheng Li and Lyndsee Midori Zhang},
   year = {2024},
-  note = {R package version 0.1.6.9009, 
+  note = {R package version 0.1.6.9010, 
 https://github.com/insightsengineering/teal.modules.hermes/},
   url = {https://insightsengineering.github.io/teal.modules.hermes/},
 }</pre>
diff --git a/main/deps/bootstrap-5.3.1/bootstrap.min.css b/main/deps/bootstrap-5.3.1/bootstrap.min.css
index 0fa31676..b174f934 100644
--- a/main/deps/bootstrap-5.3.1/bootstrap.min.css
+++ b/main/deps/bootstrap-5.3.1/bootstrap.min.css
@@ -2,4 +2,4 @@
    * Bootstrap  v5.3.1 (https://getbootstrap.com/)
    * Copyright 2011-2023 The Bootstrap Authors
    * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
-   */:root,[data-bs-theme="light"]{--bs-blue: #007bc2;--bs-indigo: #4b00c1;--bs-purple: #74149c;--bs-pink: #bf007f;--bs-red: #c10000;--bs-orange: #f45100;--bs-yellow: #f9b928;--bs-green: #00891a;--bs-teal: #00bf7f;--bs-cyan: #03c7e8;--bs-black: #000;--bs-white: #fff;--bs-gray: #707782;--bs-gray-dark: #343A46;--bs-gray-100: #f8f8f8;--bs-gray-200: #e9ecef;--bs-gray-300: #dee2e6;--bs-gray-400: #cdd4da;--bs-gray-500: #8D959E;--bs-gray-600: #707782;--bs-gray-700: #48505F;--bs-gray-800: #343A46;--bs-gray-900: #1D1F21;--bs-default: #dee2e6;--bs-primary: #007bc2;--bs-secondary: #404040;--bs-success: #00891a;--bs-info: #03c7e8;--bs-warning: #f9b928;--bs-danger: #c10000;--bs-light: #f8f8f8;--bs-dark: #202020;--bs-default-rgb: 222,226,230;--bs-primary-rgb: 0,123,194;--bs-secondary-rgb: 64,64,64;--bs-success-rgb: 0,137,26;--bs-info-rgb: 3,199,232;--bs-warning-rgb: 249,185,40;--bs-danger-rgb: 193,0,0;--bs-light-rgb: 248,248,248;--bs-dark-rgb: 32,32,32;--bs-primary-text-emphasis: 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auto}.btn-group>.btn-check:checked+.btn,.btn-group>.btn-check:focus+.btn,.btn-group>.btn:hover,.btn-group>.btn:focus,.btn-group>.btn:active,.btn-group>.btn.active,.btn-group-vertical>.btn-check:checked+.btn,.btn-group-vertical>.btn-check:focus+.btn,.btn-group-vertical>.btn:hover,.btn-group-vertical>.btn:focus,.btn-group-vertical>.btn:active,.btn-group-vertical>.btn.active{z-index:1}.btn-toolbar{display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;justify-content:flex-start;-webkit-justify-content:flex-start}.btn-toolbar .input-group{width:auto}.btn-group{border-radius:var(--bs-border-radius)}.btn-group>:not(.btn-check:first-child)+.btn,.btn-group>.btn-group:not(:first-child){margin-left:calc(var(--bs-border-width) * -1)}.btn-group>.btn:not(:last-child):not(.dropdown-toggle),.btn-group>.btn.dropdown-toggle-split:first-child,.btn-group>.btn-group:not(:last-child)>.btn{border-top-right-radius:0;border-bottom-right-radius:0}.btn-group>.btn:nth-child(n + 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-1)}.btn-group-vertical>.btn:not(:last-child):not(.dropdown-toggle),.btn-group-vertical>.btn-group:not(:last-child)>.btn{border-bottom-right-radius:0;border-bottom-left-radius:0}.btn-group-vertical>.btn~.btn,.btn-group-vertical>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-top-right-radius:0}.nav{--bs-nav-link-padding-x: 1rem;--bs-nav-link-padding-y: .5rem;--bs-nav-link-font-weight: ;--bs-nav-link-color: var(--bs-link-color);--bs-nav-link-hover-color: var(--bs-link-hover-color);--bs-nav-link-disabled-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding-left:0;margin-bottom:0;list-style:none}.nav-link{display:block;padding:var(--bs-nav-link-padding-y) var(--bs-nav-link-padding-x);font-size:var(--bs-nav-link-font-size);font-weight:var(--bs-nav-link-font-weight);color:var(--bs-nav-link-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background:none;border:0;transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.nav-link{transition:none}}.nav-link:hover,.nav-link:focus{color:var(--bs-nav-link-hover-color)}.nav-link:focus-visible{outline:0;box-shadow:0 0 0 .25rem rgba(0,123,194,0.25)}.nav-link.disabled,.nav-link:disabled{color:var(--bs-nav-link-disabled-color);pointer-events:none;cursor:default}.nav-tabs{--bs-nav-tabs-border-width: var(--bs-border-width);--bs-nav-tabs-border-color: var(--bs-border-color);--bs-nav-tabs-border-radius: var(--bs-border-radius);--bs-nav-tabs-link-hover-border-color: var(--bs-secondary-bg) var(--bs-secondary-bg) var(--bs-border-color);--bs-nav-tabs-link-active-color: var(--bs-emphasis-color);--bs-nav-tabs-link-active-bg: var(--bs-body-bg);--bs-nav-tabs-link-active-border-color: var(--bs-border-color) var(--bs-border-color) var(--bs-body-bg);border-bottom:var(--bs-nav-tabs-border-width) solid var(--bs-nav-tabs-border-color)}.nav-tabs .nav-link{margin-bottom:calc(-1 * var(--bs-nav-tabs-border-width));border:var(--bs-nav-tabs-border-width) solid transparent;border-top-left-radius:var(--bs-nav-tabs-border-radius);border-top-right-radius:var(--bs-nav-tabs-border-radius)}.nav-tabs .nav-link:hover,.nav-tabs .nav-link:focus{isolation:isolate;border-color:var(--bs-nav-tabs-link-hover-border-color)}.nav-tabs .nav-link.active,.nav-tabs .nav-item.show .nav-link{color:var(--bs-nav-tabs-link-active-color);background-color:var(--bs-nav-tabs-link-active-bg);border-color:var(--bs-nav-tabs-link-active-border-color)}.nav-tabs .dropdown-menu{margin-top:calc(-1 * 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.show>.nav-link{font-weight:700;color:var(--bs-nav-underline-link-active-color);border-bottom-color:currentcolor}.nav-fill>.nav-link,.nav-fill .nav-item{flex:1 1 auto;-webkit-flex:1 1 auto;text-align:center}.nav-justified>.nav-link,.nav-justified .nav-item{flex-basis:0;-webkit-flex-basis:0;flex-grow:1;-webkit-flex-grow:1;text-align:center}.nav-fill .nav-item .nav-link,.nav-justified .nav-item .nav-link{width:100%}.tab-content>.tab-pane{display:none}.tab-content>.active{display:block}.navbar{--bs-navbar-padding-x: .66rem;--bs-navbar-padding-y: .5rem;--bs-navbar-color: rgba(var(--bs-emphasis-color-rgb), 0.65);--bs-navbar-hover-color: rgba(var(--bs-emphasis-color-rgb), 0.8);--bs-navbar-disabled-color: rgba(var(--bs-emphasis-color-rgb), 0.3);--bs-navbar-active-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-padding-y: .3125rem;--bs-navbar-brand-margin-end: 1rem;--bs-navbar-brand-font-size: 1.25rem;--bs-navbar-brand-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-hover-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-nav-link-padding-x: .5rem;--bs-navbar-toggler-padding-y: .25rem;--bs-navbar-toggler-padding-x: .75rem;--bs-navbar-toggler-font-size: 1.25rem;--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%2829,31,33,0.75%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e");--bs-navbar-toggler-border-color: rgba(var(--bs-emphasis-color-rgb), 0.15);--bs-navbar-toggler-border-radius: var(--bs-border-radius);--bs-navbar-toggler-focus-width: .25rem;--bs-navbar-toggler-transition: box-shadow 0.15s ease-in-out;position:relative;display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-navbar-padding-y) 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.navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-md .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-md .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-md .navbar-nav-scroll{overflow:visible}.navbar-expand-md .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-md .navbar-toggler{display:none}.navbar-expand-md .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-md .offcanvas .offcanvas-header{display:none}.navbar-expand-md .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}@media (min-width: 992px){.navbar-expand-lg{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-lg .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-lg .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-lg .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-lg .navbar-nav-scroll{overflow:visible}.navbar-expand-lg .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-lg .navbar-toggler{display:none}.navbar-expand-lg .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-lg .offcanvas .offcanvas-header{display:none}.navbar-expand-lg .offcanvas 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.offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex 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ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out,border-radius 0.15s ease;--bs-accordion-border-color: var(--bs-border-color);--bs-accordion-border-width: var(--bs-border-width);--bs-accordion-border-radius: var(--bs-border-radius);--bs-accordion-inner-border-radius: calc(var(--bs-border-radius) - (var(--bs-border-width)));--bs-accordion-btn-padding-x: 1.25rem;--bs-accordion-btn-padding-y: 1rem;--bs-accordion-btn-color: var(--bs-body-color);--bs-accordion-btn-bg: var(--bs-accordion-bg);--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%231D1F21'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-icon-width: 1.25rem;--bs-accordion-btn-icon-transform: rotate(-180deg);--bs-accordion-btn-icon-transition: transform 0.2s ease-in-out;--bs-accordion-btn-active-icon: 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.accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme="dark"] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%2366b0da'%3e%3cpath 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var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: var(--bs-link-color);--bs-pagination-bg: var(--bs-body-bg);--bs-pagination-border-width: var(--bs-border-width);--bs-pagination-border-color: var(--bs-border-color);--bs-pagination-border-radius: var(--bs-border-radius);--bs-pagination-hover-color: 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reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(var(--bs-border-width) * -1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: var(--bs-border-radius-lg)}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: var(--bs-border-radius-sm)}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: var(--bs-border-radius);display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: var(--bs-border-width) solid var(--bs-alert-border-color);--bs-alert-border-radius: var(--bs-border-radius);--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: var(--bs-secondary-bg);--bs-progress-border-radius: var(--bs-border-radius);--bs-progress-box-shadow: var(--bs-box-shadow-inset);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #007bc2;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media (prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media (prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: var(--bs-body-color);--bs-list-group-bg: var(--bs-body-bg);--bs-list-group-border-color: var(--bs-border-color);--bs-list-group-border-width: var(--bs-border-width);--bs-list-group-border-radius: var(--bs-border-radius);--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: .5rem;--bs-list-group-action-color: var(--bs-secondary-color);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-tertiary-bg);--bs-list-group-action-active-color: var(--bs-body-color);--bs-list-group-action-active-bg: var(--bs-secondary-bg);--bs-list-group-disabled-color: var(--bs-secondary-color);--bs-list-group-disabled-bg: 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";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid 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var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 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var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-primary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-primary-border-subtle);--bs-list-group-active-color: var(--bs-primary-bg-subtle);--bs-list-group-active-bg: var(--bs-primary-text-emphasis);--bs-list-group-active-border-color: var(--bs-primary-text-emphasis)}.list-group-item-secondary{--bs-list-group-color: var(--bs-secondary-text-emphasis);--bs-list-group-bg: var(--bs-secondary-bg-subtle);--bs-list-group-border-color: var(--bs-secondary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-secondary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-secondary-border-subtle);--bs-list-group-active-color: var(--bs-secondary-bg-subtle);--bs-list-group-active-bg: var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' 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var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: .5rem;--bs-modal-color: ;--bs-modal-bg: var(--bs-body-bg);--bs-modal-border-color: var(--bs-border-color-translucent);--bs-modal-border-width: var(--bs-border-width);--bs-modal-border-radius: var(--bs-border-radius-lg);--bs-modal-box-shadow: 0px 1px 2px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 2px 3px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 3px 8px RGBA(var(--bslib-box-shadow-color-rgb), 0.1);--bs-modal-inner-border-radius: calc(var(--bs-border-radius-lg) - (var(--bs-border-width)));--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1.5rem;--bs-modal-header-border-color: var(--bs-border-color);--bs-modal-header-border-width: none;--bs-modal-title-line-height: 1.5;--bs-modal-footer-gap: 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.5rem;--bs-btn-font-size:.875rem;--bs-btn-border-radius: var(--bs-border-radius-sm)}.fade{transition:opacity 0.15s linear}@media (prefers-reduced-motion: reduce){.fade{transition:none}}.fade:not(.show){opacity:0}.collapse:not(.show){display:none}.collapsing{height:0;overflow:hidden;transition:height 0.35s ease}@media (prefers-reduced-motion: reduce){.collapsing{transition:none}}.collapsing.collapse-horizontal{width:0;height:auto;transition:width 0.35s ease}@media (prefers-reduced-motion: reduce){.collapsing.collapse-horizontal{transition:none}}.dropup,.dropend,.dropdown,.dropstart,.dropup-center,.dropdown-center{position:relative}.dropdown-toggle{white-space:nowrap}.dropdown-toggle::after{display:inline-block;margin-left:.255em;vertical-align:.255em;content:"";border-top:.3em solid;border-right:.3em solid transparent;border-bottom:0;border-left:.3em solid transparent}.dropdown-toggle:empty::after{margin-left:0}.dropdown-menu{--bs-dropdown-zindex: 1000;--bs-dropdown-min-width: 10rem;--bs-dropdown-padding-x: 0;--bs-dropdown-padding-y: .5rem;--bs-dropdown-spacer: .125rem;--bs-dropdown-font-size:1rem;--bs-dropdown-color: var(--bs-body-color);--bs-dropdown-bg: var(--bs-body-bg);--bs-dropdown-border-color: var(--bs-border-color-translucent);--bs-dropdown-border-radius: var(--bs-border-radius);--bs-dropdown-border-width: var(--bs-border-width);--bs-dropdown-inner-border-radius: calc(var(--bs-border-radius) - var(--bs-border-width));--bs-dropdown-divider-bg: var(--bs-border-color-translucent);--bs-dropdown-divider-margin-y: .5rem;--bs-dropdown-box-shadow: 0px 1px 2px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 3px 7px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 12px 30px RGBA(var(--bslib-box-shadow-color-rgb), 0.08);--bs-dropdown-link-color: var(--bs-body-color);--bs-dropdown-link-hover-color: var(--bs-body-color);--bs-dropdown-link-hover-bg: var(--bs-tertiary-bg);--bs-dropdown-link-active-color: #fff;--bs-dropdown-link-active-bg: #007bc2;--bs-dropdown-link-disabled-color: var(--bs-tertiary-color);--bs-dropdown-item-padding-x: 1rem;--bs-dropdown-item-padding-y: .25rem;--bs-dropdown-header-color: #707782;--bs-dropdown-header-padding-x: 1rem;--bs-dropdown-header-padding-y: .5rem;position:absolute;z-index:var(--bs-dropdown-zindex);display:none;min-width:var(--bs-dropdown-min-width);padding:var(--bs-dropdown-padding-y) var(--bs-dropdown-padding-x);margin:0;font-size:var(--bs-dropdown-font-size);color:var(--bs-dropdown-color);text-align:left;list-style:none;background-color:var(--bs-dropdown-bg);background-clip:padding-box;border:var(--bs-dropdown-border-width) solid var(--bs-dropdown-border-color);border-radius:var(--bs-dropdown-border-radius)}.dropdown-menu[data-bs-popper]{top:100%;left:0;margin-top:var(--bs-dropdown-spacer)}.dropdown-menu-start{--bs-position: start}.dropdown-menu-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-end{--bs-position: end}.dropdown-menu-end[data-bs-popper]{right:0;left:auto}@media (min-width: 576px){.dropdown-menu-sm-start{--bs-position: start}.dropdown-menu-sm-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-sm-end{--bs-position: end}.dropdown-menu-sm-end[data-bs-popper]{right:0;left:auto}}@media (min-width: 768px){.dropdown-menu-md-start{--bs-position: start}.dropdown-menu-md-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-md-end{--bs-position: end}.dropdown-menu-md-end[data-bs-popper]{right:0;left:auto}}@media (min-width: 992px){.dropdown-menu-lg-start{--bs-position: start}.dropdown-menu-lg-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-lg-end{--bs-position: end}.dropdown-menu-lg-end[data-bs-popper]{right:0;left:auto}}@media (min-width: 1200px){.dropdown-menu-xl-start{--bs-position: start}.dropdown-menu-xl-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-xl-end{--bs-position: end}.dropdown-menu-xl-end[data-bs-popper]{right:0;left:auto}}@media (min-width: 1400px){.dropdown-menu-xxl-start{--bs-position: start}.dropdown-menu-xxl-start[data-bs-popper]{right:auto;left:0}.dropdown-menu-xxl-end{--bs-position: end}.dropdown-menu-xxl-end[data-bs-popper]{right:0;left:auto}}.dropup .dropdown-menu[data-bs-popper]{top:auto;bottom:100%;margin-top:0;margin-bottom:var(--bs-dropdown-spacer)}.dropup .dropdown-toggle::after{display:inline-block;margin-left:.255em;vertical-align:.255em;content:"";border-top:0;border-right:.3em solid transparent;border-bottom:.3em solid;border-left:.3em solid transparent}.dropup .dropdown-toggle:empty::after{margin-left:0}.dropend .dropdown-menu[data-bs-popper]{top:0;right:auto;left:100%;margin-top:0;margin-left:var(--bs-dropdown-spacer)}.dropend .dropdown-toggle::after{display:inline-block;margin-left:.255em;vertical-align:.255em;content:"";border-top:.3em solid transparent;border-right:0;border-bottom:.3em solid transparent;border-left:.3em solid}.dropend .dropdown-toggle:empty::after{margin-left:0}.dropend .dropdown-toggle::after{vertical-align:0}.dropstart .dropdown-menu[data-bs-popper]{top:0;right:100%;left:auto;margin-top:0;margin-right:var(--bs-dropdown-spacer)}.dropstart .dropdown-toggle::after{display:inline-block;margin-left:.255em;vertical-align:.255em;content:""}.dropstart .dropdown-toggle::after{display:none}.dropstart .dropdown-toggle::before{display:inline-block;margin-right:.255em;vertical-align:.255em;content:"";border-top:.3em solid transparent;border-right:.3em solid;border-bottom:.3em solid transparent}.dropstart .dropdown-toggle:empty::after{margin-left:0}.dropstart .dropdown-toggle::before{vertical-align:0}.dropdown-divider{height:0;margin:var(--bs-dropdown-divider-margin-y) 0;overflow:hidden;border-top:1px solid var(--bs-dropdown-divider-bg);opacity:1}.dropdown-item{display:block;width:100%;padding:var(--bs-dropdown-item-padding-y) var(--bs-dropdown-item-padding-x);clear:both;font-weight:400;color:var(--bs-dropdown-link-color);text-align:inherit;text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;white-space:nowrap;background-color:transparent;border:0;border-radius:var(--bs-dropdown-item-border-radius, 0)}.dropdown-item:hover,.dropdown-item:focus{color:var(--bs-dropdown-link-hover-color);background-color:var(--bs-dropdown-link-hover-bg)}.dropdown-item.active,.dropdown-item:active{color:var(--bs-dropdown-link-active-color);text-decoration:none;background-color:var(--bs-dropdown-link-active-bg)}.dropdown-item.disabled,.dropdown-item:disabled{color:var(--bs-dropdown-link-disabled-color);pointer-events:none;background-color:transparent}.dropdown-menu.show{display:block}.dropdown-header{display:block;padding:var(--bs-dropdown-header-padding-y) var(--bs-dropdown-header-padding-x);margin-bottom:0;font-size:.875rem;color:var(--bs-dropdown-header-color);white-space:nowrap}.dropdown-item-text{display:block;padding:var(--bs-dropdown-item-padding-y) var(--bs-dropdown-item-padding-x);color:var(--bs-dropdown-link-color)}.dropdown-menu-dark{--bs-dropdown-color: #dee2e6;--bs-dropdown-bg: #343A46;--bs-dropdown-border-color: var(--bs-border-color-translucent);--bs-dropdown-box-shadow: ;--bs-dropdown-link-color: #dee2e6;--bs-dropdown-link-hover-color: #fff;--bs-dropdown-divider-bg: var(--bs-border-color-translucent);--bs-dropdown-link-hover-bg: rgba(255,255,255,0.15);--bs-dropdown-link-active-color: #fff;--bs-dropdown-link-active-bg: #007bc2;--bs-dropdown-link-disabled-color: #8D959E;--bs-dropdown-header-color: #8D959E}.btn-group,.btn-group-vertical{position:relative;display:inline-flex;vertical-align:middle}.btn-group>.btn,.btn-group-vertical>.btn{position:relative;flex:1 1 auto;-webkit-flex:1 1 auto}.btn-group>.btn-check:checked+.btn,.btn-group>.btn-check:focus+.btn,.btn-group>.btn:hover,.btn-group>.btn:focus,.btn-group>.btn:active,.btn-group>.btn.active,.btn-group-vertical>.btn-check:checked+.btn,.btn-group-vertical>.btn-check:focus+.btn,.btn-group-vertical>.btn:hover,.btn-group-vertical>.btn:focus,.btn-group-vertical>.btn:active,.btn-group-vertical>.btn.active{z-index:1}.btn-toolbar{display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;justify-content:flex-start;-webkit-justify-content:flex-start}.btn-toolbar .input-group{width:auto}.btn-group{border-radius:var(--bs-border-radius)}.btn-group>:not(.btn-check:first-child)+.btn,.btn-group>.btn-group:not(:first-child){margin-left:calc(var(--bs-border-width) * -1)}.btn-group>.btn:not(:last-child):not(.dropdown-toggle),.btn-group>.btn.dropdown-toggle-split:first-child,.btn-group>.btn-group:not(:last-child)>.btn{border-top-right-radius:0;border-bottom-right-radius:0}.btn-group>.btn:nth-child(n + 3),.btn-group>:not(.btn-check)+.btn,.btn-group>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-bottom-left-radius:0}.dropdown-toggle-split{padding-right:1.5em;padding-left:1.5em}.dropdown-toggle-split::after,.dropup .dropdown-toggle-split::after,.dropend .dropdown-toggle-split::after{margin-left:0}.dropstart .dropdown-toggle-split::before{margin-right:0}.btn-sm+.dropdown-toggle-split,.btn-group-sm>.btn+.dropdown-toggle-split{padding-right:.375rem;padding-left:.375rem}.btn-lg+.dropdown-toggle-split,.btn-group-lg>.btn+.dropdown-toggle-split{padding-right:.75rem;padding-left:.75rem}.btn-group-vertical{flex-direction:column;-webkit-flex-direction:column;align-items:flex-start;-webkit-align-items:flex-start;justify-content:center;-webkit-justify-content:center}.btn-group-vertical>.btn,.btn-group-vertical>.btn-group{width:100%}.btn-group-vertical>.btn:not(:first-child),.btn-group-vertical>.btn-group:not(:first-child){margin-top:calc(var(--bs-border-width) * -1)}.btn-group-vertical>.btn:not(:last-child):not(.dropdown-toggle),.btn-group-vertical>.btn-group:not(:last-child)>.btn{border-bottom-right-radius:0;border-bottom-left-radius:0}.btn-group-vertical>.btn~.btn,.btn-group-vertical>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-top-right-radius:0}.nav{--bs-nav-link-padding-x: 1rem;--bs-nav-link-padding-y: .5rem;--bs-nav-link-font-weight: ;--bs-nav-link-color: var(--bs-link-color);--bs-nav-link-hover-color: var(--bs-link-hover-color);--bs-nav-link-disabled-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding-left:0;margin-bottom:0;list-style:none}.nav-link{display:block;padding:var(--bs-nav-link-padding-y) var(--bs-nav-link-padding-x);font-size:var(--bs-nav-link-font-size);font-weight:var(--bs-nav-link-font-weight);color:var(--bs-nav-link-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background:none;border:0;transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.nav-link{transition:none}}.nav-link:hover,.nav-link:focus{color:var(--bs-nav-link-hover-color)}.nav-link:focus-visible{outline:0;box-shadow:0 0 0 .25rem rgba(0,123,194,0.25)}.nav-link.disabled,.nav-link:disabled{color:var(--bs-nav-link-disabled-color);pointer-events:none;cursor:default}.nav-tabs{--bs-nav-tabs-border-width: var(--bs-border-width);--bs-nav-tabs-border-color: var(--bs-border-color);--bs-nav-tabs-border-radius: var(--bs-border-radius);--bs-nav-tabs-link-hover-border-color: var(--bs-secondary-bg) var(--bs-secondary-bg) var(--bs-border-color);--bs-nav-tabs-link-active-color: var(--bs-emphasis-color);--bs-nav-tabs-link-active-bg: var(--bs-body-bg);--bs-nav-tabs-link-active-border-color: var(--bs-border-color) var(--bs-border-color) var(--bs-body-bg);border-bottom:var(--bs-nav-tabs-border-width) solid var(--bs-nav-tabs-border-color)}.nav-tabs .nav-link{margin-bottom:calc(-1 * var(--bs-nav-tabs-border-width));border:var(--bs-nav-tabs-border-width) solid transparent;border-top-left-radius:var(--bs-nav-tabs-border-radius);border-top-right-radius:var(--bs-nav-tabs-border-radius)}.nav-tabs .nav-link:hover,.nav-tabs .nav-link:focus{isolation:isolate;border-color:var(--bs-nav-tabs-link-hover-border-color)}.nav-tabs .nav-link.active,.nav-tabs .nav-item.show .nav-link{color:var(--bs-nav-tabs-link-active-color);background-color:var(--bs-nav-tabs-link-active-bg);border-color:var(--bs-nav-tabs-link-active-border-color)}.nav-tabs .dropdown-menu{margin-top:calc(-1 * var(--bs-nav-tabs-border-width));border-top-left-radius:0;border-top-right-radius:0}.nav-pills{--bs-nav-pills-border-radius: var(--bs-border-radius);--bs-nav-pills-link-active-color: #fff;--bs-nav-pills-link-active-bg: #007bc2}.nav-pills .nav-link{border-radius:var(--bs-nav-pills-border-radius)}.nav-pills .nav-link.active,.nav-pills .show>.nav-link{color:var(--bs-nav-pills-link-active-color);background-color:var(--bs-nav-pills-link-active-bg)}.nav-underline{--bs-nav-underline-gap: 1rem;--bs-nav-underline-border-width: .125rem;--bs-nav-underline-link-active-color: var(--bs-emphasis-color);gap:var(--bs-nav-underline-gap)}.nav-underline .nav-link{padding-right:0;padding-left:0;border-bottom:var(--bs-nav-underline-border-width) solid transparent}.nav-underline .nav-link:hover,.nav-underline .nav-link:focus{border-bottom-color:currentcolor}.nav-underline .nav-link.active,.nav-underline .show>.nav-link{font-weight:700;color:var(--bs-nav-underline-link-active-color);border-bottom-color:currentcolor}.nav-fill>.nav-link,.nav-fill .nav-item{flex:1 1 auto;-webkit-flex:1 1 auto;text-align:center}.nav-justified>.nav-link,.nav-justified .nav-item{flex-basis:0;-webkit-flex-basis:0;flex-grow:1;-webkit-flex-grow:1;text-align:center}.nav-fill .nav-item .nav-link,.nav-justified .nav-item .nav-link{width:100%}.tab-content>.tab-pane{display:none}.tab-content>.active{display:block}.navbar{--bs-navbar-padding-x: .66rem;--bs-navbar-padding-y: .5rem;--bs-navbar-color: rgba(var(--bs-emphasis-color-rgb), 0.65);--bs-navbar-hover-color: rgba(var(--bs-emphasis-color-rgb), 0.8);--bs-navbar-disabled-color: rgba(var(--bs-emphasis-color-rgb), 0.3);--bs-navbar-active-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-padding-y: .3125rem;--bs-navbar-brand-margin-end: 1rem;--bs-navbar-brand-font-size: 1.25rem;--bs-navbar-brand-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-hover-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-nav-link-padding-x: .5rem;--bs-navbar-toggler-padding-y: .25rem;--bs-navbar-toggler-padding-x: .75rem;--bs-navbar-toggler-font-size: 1.25rem;--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%2829,31,33,0.75%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e");--bs-navbar-toggler-border-color: rgba(var(--bs-emphasis-color-rgb), 0.15);--bs-navbar-toggler-border-radius: var(--bs-border-radius);--bs-navbar-toggler-focus-width: .25rem;--bs-navbar-toggler-transition: box-shadow 0.15s ease-in-out;position:relative;display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-navbar-padding-y) 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.navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-md .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-md .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-md .navbar-nav-scroll{overflow:visible}.navbar-expand-md .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-md .navbar-toggler{display:none}.navbar-expand-md .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-md .offcanvas .offcanvas-header{display:none}.navbar-expand-md .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}@media (min-width: 992px){.navbar-expand-lg{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-lg .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-lg .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-lg .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-lg .navbar-nav-scroll{overflow:visible}.navbar-expand-lg .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-lg .navbar-toggler{display:none}.navbar-expand-lg .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-lg .offcanvas .offcanvas-header{display:none}.navbar-expand-lg .offcanvas 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!important;transform:none !important;transition:none}.navbar-expand-xl .offcanvas .offcanvas-header{display:none}.navbar-expand-xl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}@media (min-width: 1400px){.navbar-expand-xxl{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-xxl .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-xxl .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-xxl .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-xxl .navbar-nav-scroll{overflow:visible}.navbar-expand-xxl .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-xxl .navbar-toggler{display:none}.navbar-expand-xxl .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand .navbar-toggler{display:none}.navbar-expand .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand .offcanvas .offcanvas-header{display:none}.navbar-expand .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}.navbar-dark,.navbar[data-bs-theme="dark"]{--bs-navbar-color: rgba(var(--bs-emphasis-color-rgb), 0.55);--bs-navbar-hover-color: rgba(var(--bs-emphasis-color-rgb), 0.75);--bs-navbar-disabled-color: rgba(var(--bs-emphasis-color-rgb), 0.25);--bs-navbar-active-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-hover-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-toggler-border-color: rgba(var(--bs-emphasis-color-rgb), 0.1);--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%28255,255,255,0.75%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e")}[data-bs-theme="dark"] .navbar-toggler-icon{--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%28255,255,255,0.75%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e")}.card{--bs-card-spacer-y: 1rem;--bs-card-spacer-x: 1rem;--bs-card-title-spacer-y: .5rem;--bs-card-title-color: ;--bs-card-subtitle-color: ;--bs-card-border-width: var(--bs-border-width);--bs-card-border-color: var(--bs-border-color-translucent);--bs-card-border-radius: 8px;--bs-card-box-shadow: ;--bs-card-inner-border-radius: calc(8px - (var(--bs-border-width)));--bs-card-cap-padding-y: .5rem;--bs-card-cap-padding-x: 1rem;--bs-card-cap-bg: rgba(var(--bs-body-color-rgb), 0.03);--bs-card-cap-color: ;--bs-card-height: ;--bs-card-color: ;--bs-card-bg: var(--bs-body-bg);--bs-card-img-overlay-padding: 1rem;--bs-card-group-margin: .75rem;position:relative;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;min-width:0;height:var(--bs-card-height);color:var(--bs-body-color);word-wrap:break-word;background-color:var(--bs-card-bg);background-clip:border-box;border:var(--bs-card-border-width) solid var(--bs-card-border-color);border-radius:var(--bs-card-border-radius)}.card>hr{margin-right:0;margin-left:0}.card>.list-group{border-top:inherit;border-bottom:inherit}.card>.list-group:first-child{border-top-width:0;border-top-left-radius:var(--bs-card-inner-border-radius);border-top-right-radius:var(--bs-card-inner-border-radius)}.card>.list-group:last-child{border-bottom-width:0;border-bottom-right-radius:var(--bs-card-inner-border-radius);border-bottom-left-radius:var(--bs-card-inner-border-radius)}.card>.card-header+.list-group,.card>.list-group+.card-footer{border-top:0}.card-body{flex:1 1 auto;-webkit-flex:1 1 auto;padding:var(--bs-card-spacer-y) var(--bs-card-spacer-x);color:var(--bs-card-color)}.card-title{margin-bottom:var(--bs-card-title-spacer-y);color:var(--bs-card-title-color)}.card-subtitle{margin-top:calc(-.5 * 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wrap;-webkit-flex-flow:row wrap}.card-group>.card{flex:1 0 0%;-webkit-flex:1 0 0%;margin-bottom:0}.card-group>.card+.card{margin-left:0;border-left:0}.card-group>.card:not(:last-child){border-top-right-radius:0;border-bottom-right-radius:0}.card-group>.card:not(:last-child) .card-img-top,.card-group>.card:not(:last-child) .card-header{border-top-right-radius:0}.card-group>.card:not(:last-child) .card-img-bottom,.card-group>.card:not(:last-child) .card-footer{border-bottom-right-radius:0}.card-group>.card:not(:first-child){border-top-left-radius:0;border-bottom-left-radius:0}.card-group>.card:not(:first-child) .card-img-top,.card-group>.card:not(:first-child) .card-header{border-top-left-radius:0}.card-group>.card:not(:first-child) .card-img-bottom,.card-group>.card:not(:first-child) .card-footer{border-bottom-left-radius:0}}.accordion{--bs-accordion-color: var(--bs-body-color);--bs-accordion-bg: var(--bs-body-bg);--bs-accordion-transition: color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out,border-radius 0.15s ease;--bs-accordion-border-color: var(--bs-border-color);--bs-accordion-border-width: var(--bs-border-width);--bs-accordion-border-radius: var(--bs-border-radius);--bs-accordion-inner-border-radius: calc(var(--bs-border-radius) - (var(--bs-border-width)));--bs-accordion-btn-padding-x: 1.25rem;--bs-accordion-btn-padding-y: 1rem;--bs-accordion-btn-color: var(--bs-body-color);--bs-accordion-btn-bg: var(--bs-accordion-bg);--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%231D1F21'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-icon-width: 1.25rem;--bs-accordion-btn-icon-transform: rotate(-180deg);--bs-accordion-btn-icon-transition: transform 0.2s ease-in-out;--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%2300314e'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #80bde1;--bs-accordion-btn-focus-box-shadow: 0 0 0 .25rem rgba(0,123,194,0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: ;--bs-accordion-active-bg: }.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;border-radius:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media (prefers-reduced-motion: reduce){.accordion-button{transition:none}}.accordion-button:not(.collapsed){color:var(--bs-accordion-active-color);background-color:var(--bs-accordion-active-bg);box-shadow:inset 0 calc(-1 * var(--bs-accordion-border-width)) 0 var(--bs-accordion-border-color)}.accordion-button:not(.collapsed)::after{background-image:var(--bs-accordion-btn-active-icon);transform:var(--bs-accordion-btn-icon-transform)}.accordion-button::after{flex-shrink:0;-webkit-flex-shrink:0;width:var(--bs-accordion-btn-icon-width);height:var(--bs-accordion-btn-icon-width);margin-left:auto;content:"";background-image:var(--bs-accordion-btn-icon);background-repeat:no-repeat;background-size:var(--bs-accordion-btn-icon-width);transition:var(--bs-accordion-btn-icon-transition)}@media (prefers-reduced-motion: reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme="dark"] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%2366b0da'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%2366b0da'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e")}.breadcrumb{--bs-breadcrumb-padding-x: 0;--bs-breadcrumb-padding-y: 0;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: ;--bs-breadcrumb-divider-color: var(--bs-secondary-color);--bs-breadcrumb-item-padding-x: .5rem;--bs-breadcrumb-item-active-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: var(--bs-link-color);--bs-pagination-bg: var(--bs-body-bg);--bs-pagination-border-width: var(--bs-border-width);--bs-pagination-border-color: var(--bs-border-color);--bs-pagination-border-radius: var(--bs-border-radius);--bs-pagination-hover-color: var(--bs-link-hover-color);--bs-pagination-hover-bg: var(--bs-tertiary-bg);--bs-pagination-hover-border-color: var(--bs-border-color);--bs-pagination-focus-color: var(--bs-link-hover-color);--bs-pagination-focus-bg: var(--bs-secondary-bg);--bs-pagination-focus-box-shadow: 0 0 0 .25rem rgba(0,123,194,0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #007bc2;--bs-pagination-active-border-color: #007bc2;--bs-pagination-disabled-color: var(--bs-secondary-color);--bs-pagination-disabled-bg: var(--bs-secondary-bg);--bs-pagination-disabled-border-color: var(--bs-border-color);display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(var(--bs-border-width) * -1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: var(--bs-border-radius-lg)}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: var(--bs-border-radius-sm)}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: var(--bs-border-radius);display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: var(--bs-border-width) solid var(--bs-alert-border-color);--bs-alert-border-radius: var(--bs-border-radius);--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: var(--bs-secondary-bg);--bs-progress-border-radius: var(--bs-border-radius);--bs-progress-box-shadow: var(--bs-box-shadow-inset);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #007bc2;--bs-progress-bar-transition: width 0.6s 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var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: 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var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: 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var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e");--bs-btn-close-opacity: .5;--bs-btn-close-hover-opacity: .75;--bs-btn-close-focus-shadow: 0 0 0 .25rem rgba(0,123,194,0.25);--bs-btn-close-focus-opacity: 1;--bs-btn-close-disabled-opacity: .25;--bs-btn-close-white-filter: invert(1) grayscale(100%) brightness(200%);box-sizing:content-box;width:1em;height:1em;padding:.25em .25em;color:var(--bs-btn-close-color);background:transparent var(--bs-btn-close-bg) center/1em auto no-repeat;border:0;border-radius:3px;opacity:var(--bs-btn-close-opacity)}.btn-close:hover{color:var(--bs-btn-close-color);text-decoration:none;opacity:var(--bs-btn-close-hover-opacity)}.btn-close:focus{outline:0;box-shadow:var(--bs-btn-close-focus-shadow);opacity:var(--bs-btn-close-focus-opacity)}.btn-close:disabled,.btn-close.disabled{pointer-events:none;user-select:none;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;opacity:var(--bs-btn-close-disabled-opacity)}.btn-close-white{filter:var(--bs-btn-close-white-filter)}[data-bs-theme="dark"] .btn-close{filter:var(--bs-btn-close-white-filter)}.toast{--bs-toast-zindex: 1090;--bs-toast-padding-x: .75rem;--bs-toast-padding-y: .5rem;--bs-toast-spacing: 1.5rem;--bs-toast-max-width: 350px;--bs-toast-font-size:.875rem;--bs-toast-color: ;--bs-toast-bg: rgba(var(--bs-body-bg-rgb), 0.85);--bs-toast-border-width: var(--bs-border-width);--bs-toast-border-color: var(--bs-border-color-translucent);--bs-toast-border-radius: var(--bs-border-radius);--bs-toast-box-shadow: var(--bs-box-shadow);--bs-toast-header-color: var(--bs-secondary-color);--bs-toast-header-bg: rgba(var(--bs-body-bg-rgb), 0.85);--bs-toast-header-border-color: var(--bs-border-color-translucent);width:var(--bs-toast-max-width);max-width:100%;font-size:var(--bs-toast-font-size);color:var(--bs-toast-color);pointer-events:auto;background-color:var(--bs-toast-bg);background-clip:padding-box;border:var(--bs-toast-border-width) solid var(--bs-toast-border-color);box-shadow:var(--bs-toast-box-shadow);border-radius:var(--bs-toast-border-radius)}.toast.showing{opacity:0}.toast:not(.show){display:none}.toast-container{--bs-toast-zindex: 1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color);border-top-left-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width));border-top-right-radius:calc(var(--bs-toast-border-radius) - var(--bs-toast-border-width))}.toast-header .btn-close{margin-right:calc(-.5 * 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td{background-color:var(--bs-table-active-bg)}.table.dataTable.dataTable.table-hover>tbody>tr:hover:not(.selected)>*{box-shadow:inset 0 0 0 9999px var(--bs-table-hover-bg)}thead,tbody,tfoot,tr,td,th{border:none}.table>thead{border-bottom:1px solid var(--bs-table-color)}th{font-weight:600}.datatables .dataTables_wrapper div.dataTables_info{padding-top:1.65rem;font-size:.95rem}.datatables .dataTables_paginate{padding-top:1rem}.datatables .paginate_button a{font-size:.95rem}.datatables .dataTables_length,.datatables .dataTables_filter{padding-bottom:1rem}.datatables .dataTables_wrapper .dt-row{max-width:100%;overflow:auto}.datatables .dataTables_wrapper .dataTables_length select,.datatables .dataTables_wrapper .dataTables_filter input{border:none;border-bottom:1px solid var(--bs-body-color);border-radius:0}.bslib-card-table-sm.bslib-card[data-full-screen="false"] .datatables .dataTables_wrapper{font-size:85%}.bslib-card-table-sm.bslib-card[data-full-screen="false"] .datatables 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.input-group-addon{margin-right:-1px}.btn-outline-default,.btn-default:not(.btn-primary,.btn-secondary,.btn-info,.btn-success,.btn-danger,.btn-warning,.btn-light,.btn-dark,.btn-link,[class*="btn-outline-"]){--bs-btn-color: #404040;--bs-btn-border-color: #404040;--bs-btn-hover-color: #fff;--bs-btn-hover-bg: #404040;--bs-btn-hover-border-color: #404040;--bs-btn-focus-shadow-rgb: 64,64,64;--bs-btn-active-color: #fff;--bs-btn-active-bg: #404040;--bs-btn-active-border-color: #404040;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #404040;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #404040;--bs-btn-bg: transparent;--bs-gradient: none}[data-bs-theme="dark"] .btn-outline-default,[data-bs-theme="dark"] .btn-default:not(.btn-primary,.btn-secondary,.btn-info,.btn-success,.btn-danger,.btn-warning,.btn-light,.btn-dark,.btn-link,[class*="btn-outline-"]){--bs-btn-color: #dee2e6;--bs-btn-border-color: #dee2e6;--bs-btn-hover-color: #000;--bs-btn-hover-bg: #dee2e6;--bs-btn-hover-border-color: #dee2e6;--bs-btn-focus-shadow-rgb: 222,226,230;--bs-btn-active-color: #000;--bs-btn-active-bg: #dee2e6;--bs-btn-active-border-color: #dee2e6;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #dee2e6;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #dee2e6;--bs-btn-bg: transparent;--bs-gradient: none}.selectize-control.plugin-remove_button .item{align-items:flex-start !important}.selectize-control.plugin-remove_button .item .remove{border-left:none !important}.bslib-card{box-shadow:var(--bslib-card-box-shadow, 0px 0px 2px 0px RGBA(var(--bslib-box-shadow-color-rgb), 0.14),0px 2px 4px 0px RGBA(var(--bslib-box-shadow-color-rgb), 0.16));border-color:var(--bslib-card-border-color, transparent)}.bslib-card.bslib-value-box.default{--bslib-value-box-border-color-default: var(--bslib-card-border-color, transparent)}.bslib-card .bslib-card{--bslib-card-box-shadow: ;--bslib-card-border-color: var(--bs-card-border-color)}.bslib-card .bslib-card.bslib-value-box.default{--bslib-value-box-border-color-default: var(--bs-card-border-color, var(--bs-border-color-translucent))}.bslib-card-box-shadow-sm{--bslib-card-box-shadow: var(--bslib-card-box-shadow-sm, 0px 0px 2px 0px RGBA(var(--bslib-box-shadow-color-rgb), 0.14),0px 2px 4px 0px RGBA(var(--bslib-box-shadow-color-rgb), 0.16))}.bslib-card-box-shadow-md{--bslib-card-box-shadow: var(--bslib-card-box-shadow-md, 0px 1px 2px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 3px 7px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 12px 30px RGBA(var(--bslib-box-shadow-color-rgb), 0.08))}.bslib-card-box-shadow-lg{--bslib-card-box-shadow: var(--bslib-card-box-shadow-lg, 0px 4px 10px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 12px 30px RGBA(var(--bslib-box-shadow-color-rgb), 0.17))}.bslib-card-box-shadow-none{--bslib-card-box-shadow: none;--bslib-card-border-color: var(--bs-card-border-color)}.popover{--bs-popover-shadow: 0px 1px 2px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 3px 7px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 12px 30px RGBA(var(--bslib-box-shadow-color-rgb), 0.08);box-shadow:var(--bs-popover-shadow)}:root{--bslib-dashboard-sidebar-bg: var(--bs-body-bg);--bslib-dashboard-sidebar-main-bg: var(--bs-body-bg);--bslib-dashboard-main-bg: rgb(247, 247, 247);--bs-card-border-color: var(--bslib-dashboard-border-color-translucent, var(--bs-border-color-translucent));--bslib-dashboard-card-cap-bg: var(--bs-body-bg);--bslib-dashboard-card-header-font-weight: 600;--bslib-sidebar-bg: var(--bs-body-bg);--bslib-sidebar-fg: var(--bs-color)}[data-bs-theme="dark"]{--bslib-dashboard-main-bg: rgb(20, 20, 24)}.bslib-card{--bs-card-cap-bg: var(--bslib-dashboard-card-cap-bg)}.bslib-card .card-header,.bslib-card .card-footer{font-size:0.9rem}.bslib-card .card-header{font-weight:var(--bslib-dashboard-card-header-font-weight);line-height:1.375rem}.bslib-page-dashboard,.main:has(.tab-content>.bslib-page-dashboard.active){background-color:var(--bslib-dashboard-main-bg);--_main-bg: var(--bslib-dashboard-main-bg)}.bslib-page-navbar>.navbar,.bslib-page-dashboard>.navbar{--bslib-navbar-default-bg: var(--bs-body-bg);--bslib-navbar-inverse-bg: var(--bs-body-color)}.bslib-page-navbar>.navbar+div,.bslib-page-dashboard>.navbar+div{border-top:var(--bs-border-width) solid var(--bs-border-color-translucent)}.bslib-page-navbar>.navbar+div>.bslib-sidebar-layout,.bslib-page-navbar>.navbar+div>.tab-content>.tab-pane.active.html-fill-container>.bslib-sidebar-layout.html-fill-item,.bslib-page-dashboard>.navbar+div>.bslib-sidebar-layout,.bslib-page-dashboard>.navbar+div>.tab-content>.tab-pane.active.html-fill-container>.bslib-sidebar-layout.html-fill-item{border-top:none !important}.bslib-page-sidebar{--bslib-page-sidebar-title-bg: var(--bs-body-bg);--bslib-page-sidebar-title-color: var(--bs-body-color)}.bslib-page-sidebar .bslib-page-title{border-color:var(--bs-border-color-translucent)}.nav-underline{--bs-link-color: rgba(var(--bs-body-color-rgb), 0.65);--bs-link-hover-color: rgba(var(--bs-body-color-rgb), 0.8);--bs-nav-link-font-size: 0.875rem}.nav-underline .nav-link{padding-left:5px !important;padding-right:5px !important}.nav-underline .nav-link.active{font-weight:500}.navbar-collapse.show .nav-underline,.navbar-collapse.collapsing .nav-underline{--bs-nav-underline-border-width: 0;--bs-nav-underline-gap: 0}.navbar .nav-underline .nav-link{padding-bottom:calc(var(--bs-navbar-padding-y, .5rem) * 2);margin-bottom:calc(var(--bs-navbar-padding-y, .5rem) * -1)}.bslib-value-box.default .value-box-showcase>i.bi{background:linear-gradient(140deg, #007bc2 36%, #74149c 180%) #007bc2;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.bslib-value-box.default .value-box-showcase>i.fa{background:linear-gradient(140deg, #007bc2 36%, #74149c 180%) #007bc2;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.bslib-value-box.default .value-box-showcase>i.fas{background:linear-gradient(140deg, #007bc2 36%, #74149c 180%) #007bc2;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.bslib-value-box.default .value-box-showcase>i.far{background:linear-gradient(140deg, #007bc2 36%, #74149c 180%) #007bc2;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.bslib-value-box.default .value-box-showcase>i.fab{background:linear-gradient(140deg, #007bc2 36%, #74149c 180%) #007bc2;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.bslib-value-box.default .value-box-showcase>i.material-icons{background:linear-gradient(140deg, #007bc2 36%, #74149c 180%) #007bc2;-webkit-background-clip:text;-webkit-text-fill-color:transparent}.bslib-value-box.default .value-box-showcase>svg.bi{fill:url("#bslib---icon-gradient") #007bc2 !important}.bslib-value-box.default .value-box-showcase>svg.fa{fill:url("#bslib---icon-gradient") #007bc2 !important}.bslib-value-box.default .value-box-showcase>svg.fas{fill:url("#bslib---icon-gradient") #007bc2 !important}.bslib-value-box.default .value-box-showcase>svg.far{fill:url("#bslib---icon-gradient") #007bc2 !important}.bslib-value-box.default .value-box-showcase>svg.fab{fill:url("#bslib---icon-gradient") #007bc2 !important}.bslib-value-box.default .value-box-showcase>svg.material-icons{fill:url("#bslib---icon-gradient") #007bc2 !important}.bslib-value-box.text-info{color:#028097 !important}.bslib-value-box.text-info,.bslib-value-box.text-info.text-cyan{--bslib-color-fg: $cyan !important}.bslib-value-box.text-light{--bslib-color-fg: $gray-600 !important}.bslib-value-box.text-warning{color:#A87600 !important}.bslib-value-box.text-warning,.bslib-value-box.text-warning.text-yellow{--bslib-color-fg: $warning !important}.bslib-value-box.text-teal.text-teal{--bslib-color-fg: #008558}.modal-body,.modal-footer{padding:1.5rem}.modal-header .btn-close{align-self:start;display:flex}#shiny-modal-wrapper:has(~.modal-backdrop) .modal{backdrop-filter:blur(2px)}#shiny-notification-panel#shiny-notification-panel{position:fixed;bottom:calc(var(--bslib-spacer, 1rem) / 2);right:calc(var(--bslib-spacer, 1rem) / 2);width:450px;z-index:1090}.progress-message{margin-right:.6rem}.shiny-notification.shiny-notification{position:relative;opacity:0.96;padding:2rem;margin:var(--bslib-spacer, 1rem);border:1px solid var(--bs-border-color-translucent);border-radius:8px;box-shadow:0px 1px 2px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 3px 7px RGBA(var(--bslib-box-shadow-color-rgb), 0.1),0px 12px 30px RGBA(var(--bslib-box-shadow-color-rgb), 0.08)}.shiny-notification.shiny-notification .shiny-notification-close{position:absolute;font-size:1.5em;width:2rem;height:2rem;top:0;right:0;bottom:unset;display:flex;align-items:center;justify-content:center;padding:0.25rem;cursor:pointer;font-weight:200;color:currentColor}.shiny-notification.shiny-notification .shiny-notification-close:hover{font-weight:normal}.shiny-notification.shiny-notification .shiny-notification-content-text :last-child{margin-bottom:0}.row>main{max-width:50rem}@media (min-width: 1200px) and (max-width: 1399.98px){.container .row{justify-content:space-evenly}}@media (min-width: 1400px){body{font-size:18px}.col-md-3{margin-left:5rem}}.navbar-nav .nav-item>.nav-link{border-radius:3px;padding:0.5rem}.navbar>.container{align-items:baseline;-webkit-align-items:baseline}.navbar-light .navbar-nav .active>.nav-link{background:#e9ecef;color:#1D1F21}.navbar-dark .navbar-nav .active>.nav-link{background:#343A46;color:#fff}.navbar-dark .navbar-nav .nav-item>.nav-link:hover,.navbar-light .navbar-nav .nav-item>.nav-link:hover{background:rgba(0,123,194,0.1)}.navbar-dark input[type="search"]{border-color:#707782;background-color:#1D1F21;color:#e9ecef}input[type="search"]{border-color:#dee2e6;width:12rem}.headroom{will-change:transform;transition:transform 400ms ease}.headroom--pinned{transform:translateY(0%)}.headroom--unpinned{transform:translateY(-100%)}.row>main,.row>aside{margin-top:56px}html,body{scroll-padding:56px}@media (min-width: 576px){#toc{position:sticky;top:56px;max-height:calc(100vh - 56px - 1rem);overflow-y:auto}}aside h2,aside .h2{margin-top:1.5rem;font-size:1.25rem}aside .roles{color:#4a4c4d}aside .list-unstyled li{margin-bottom:0.5rem}aside .dev-status .list-unstyled li{margin-bottom:0.1rem}@media (max-width: 575.98px){aside{margin:0.5rem;width:calc(100vw - 1rem);background-color:#f8f8f8;border-color:#dee2e6;border-radius:3px}aside h2:first-child,aside .h2:first-child{margin-top:1rem}}body{position:relative}#toc>.nav{margin-bottom:1rem}#toc>.nav a.nav-link{color:inherit;padding:0.25rem 0.5rem;margin-bottom:2px;border-radius:3px;border:0 solid #dee2e6}#toc>.nav a.nav-link:hover,#toc>.nav a.nav-link:focus{background-color:rgba(0,123,194,0.1);color:#000}#toc>.nav a.nav-link.active{background-color:#e8e9e9;color:#000}#toc>.nav .nav a.nav-link{margin-left:0.5rem}#toc>.nav .nav{display:none !important}#toc>.nav a.active+.nav{display:flex !important}footer{margin:1rem 0 1rem 0;font-size:.875em;border-top:1px solid #dee2e6;background:rgba(0,0,0,0);color:#4a4c4d;display:flex;column-gap:1rem}@media (max-width: 575.98px){footer{flex-direction:column}}@media (min-width: 576px){footer .pkgdown-footer-right{text-align:right}}footer div{flex:1 1 auto}html,body{height:100%}body>.container{min-height:100%;display:flex;flex-direction:column}body>.container .row{flex:1 0 auto}::selection{background-color:#cce5f3}main img{max-width:100%;height:auto}main table{display:block;overflow:auto}body{font-display:fallback}.page-header{border-bottom:1px solid #dee2e6;padding-bottom:0.5rem;margin-bottom:0.5rem;margin-top:1.5rem}dd{margin-left:1.5rem}summary{margin-bottom:0.5rem}details{margin-bottom:1rem}.html-widget{margin-bottom:1rem}a.anchor{display:none;margin-left:5px;width:Min(0.9em, 20px);height:Min(0.9em, 20px);background-image:url(../../link.svg);background-repeat:no-repeat;background-size:Min(0.9em, 20px) Min(0.9em, 20px);background-position:center center}h2:hover .anchor,.h2:hover .anchor,h3:hover .anchor,.h3:hover .anchor,h4:hover .anchor,.h4:hover .anchor,h5:hover .anchor,.h5:hover .anchor,h6:hover .anchor,.h6:hover .anchor{display:inline-block}.orcid{color:#A6CE39;margin-right:4px}.fab{font-family:"Font Awesome 5 Brands" !important}img.logo{float:right;width:100px;margin-left:30px}.template-home img.logo{width:120px}@media (max-width: 575.98px){img.logo{width:80px}}@media (min-width: 576px){.page-header{min-height:88px}.template-home .page-header{min-height:104px}}.line-block{margin-bottom:1rem}.template-reference-index dt{font-weight:normal}.template-reference-index code{word-wrap:normal}.icon{float:right}.icon img{width:40px}a.footnote-ref{cursor:pointer}.popover{width:Min(100vw, 32rem);font-size:0.9rem;box-shadow:4px 4px 8px rgba(0,0,0,0.3)}.popover-body{padding:0.75rem}.popover-body p:last-child{margin-bottom:0}.tab-content{padding:1rem}.tabset-pills .tab-content{border:solid 1px #e5e5e5}.tab-content{display:flex}.tab-content>.tab-pane{display:block;visibility:hidden;margin-right:-100%;width:100%}.tab-content>.active{visibility:visible}div.csl-entry{clear:both}.hanging-indent div.csl-entry{margin-left:2em;text-indent:-2em}div.csl-left-margin{min-width:2em;float:left}div.csl-right-inline{margin-left:2em;padding-left:1em}div.csl-indent{margin-left:2em}pre,pre code{word-wrap:normal}code{overflow-wrap:break-word}.hasCopyButton{position:relative}.btn-copy-ex{position:absolute;right:5px;top:5px;visibility:hidden}.hasCopyButton:hover button.btn-copy-ex{visibility:visible}pre{padding:1rem 0.5rem}@media (max-width: 575.98px){div>div>pre{margin-left:calc(var(--bs-gutter-x) * -.5);margin-right:calc(var(--bs-gutter-x) * -.5);border-radius:0;padding-left:1rem;padding-right:1rem}.btn-copy-ex{right:calc(var(--bs-gutter-x) * -.5 + 5px)}}code a:any-link{color:inherit;text-decoration-color:#707782}pre code{padding:0;background:transparent}pre code .error,pre code .warning{font-weight:bolder}pre .img img,pre .r-plt img{margin:5px 0;background-color:#fff}@media print{code a:link:after,code a:visited:after{content:""}}a.sourceLine:hover{text-decoration:none}mark,.mark{background:linear-gradient(-100deg, rgba(3,199,232,0.2), rgba(3,199,232,0.7) 95%, rgba(3,199,232,0.1))}.algolia-autocomplete .aa-hint{color:#1D1F21}.algolia-autocomplete .aa-dropdown-menu{width:Max(100%, 20rem);background-color:#fff;border:1px solid var(--bs-border-color);margin-top:2px;max-height:50vh;overflow-y:auto}.algolia-autocomplete .aa-dropdown-menu .aa-suggestion{cursor:pointer;padding:5px 4px;border-bottom:1px #e9ecef solid;font-size:0.9rem;color:#1D1F21}.search-details{font-size:0.9rem;color:#007bc2;display:inline;font-weight:bolder}.algolia-autocomplete .aa-dropdown-menu .aa-suggestion.aa-cursor{background-color:#e6f2f9}pre{background-color:#f1f3f5}pre code{color:#003B4F}pre code span.al{color:#AD0000}pre code span.an{color:#5E5E5E}pre code span.at{color:#657422}pre code span.bn{color:#AD0000}pre code span.cf{color:#003B4F}pre code span.ch{color:#20794D}pre code span.cn{color:#8f5902}pre code span.co{color:#5E5E5E}pre code span.cv{color:#5E5E5E;font-style:italic}pre code span.do{color:#5E5E5E;font-style:italic}pre code span.dt{color:#AD0000}pre code span.dv{color:#AD0000}pre code span.er{color:#AD0000}pre code span.fl{color:#AD0000}pre code span.fu{color:#4758AB}pre code span.im{color:#00769E}pre code span.in{color:#5E5E5E}pre code span.kw{color:#003B4F}pre code span.op{color:#5E5E5E}pre code span.ot{color:#003B4F}pre code span.pp{color:#AD0000}pre code span.sc{color:#5E5E5E}pre code span.ss{color:#20794D}pre code span.st{color:#20794D}pre code span.va{color:#111111}pre code span.vs{color:#20794D}pre code span.wa{color:#5E5E5E;font-style:italic}
diff --git a/main/deps/bootstrap-5.3.1/font.css b/main/deps/bootstrap-5.3.1/font.css
index b74f3e13..fa85d557 100644
--- a/main/deps/bootstrap-5.3.1/font.css
+++ b/main/deps/bootstrap-5.3.1/font.css
@@ -1,124 +1,1452 @@
+/* cyrillic-ext */
 @font-face {
   font-family: 'Open Sans';
   font-style: italic;
   font-weight: 300;
-  font-stretch: normal;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memQYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWq8tWZ0Pw86hd0Rk5hkaVQ.woff) format('woff');
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtE6F15M.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
 }
+/* cyrillic */
 @font-face {
   font-family: 'Open Sans';
   font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWvU6F15M.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtU6F15M.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuk6F15M.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWu06F15M.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWxU6F15M.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqW106F15M.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtk6F15M.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWt06F15M.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuU6F.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtE6F15M.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWvU6F15M.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtU6F15M.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuk6F15M.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWu06F15M.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWxU6F15M.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqW106F15M.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtk6F15M.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWt06F15M.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuU6F.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtE6F15M.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWvU6F15M.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtU6F15M.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuk6F15M.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWu06F15M.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWxU6F15M.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqW106F15M.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtk6F15M.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWt06F15M.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuU6F.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtE6F15M.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWvU6F15M.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtU6F15M.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuk6F15M.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWu06F15M.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWxU6F15M.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqW106F15M.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtk6F15M.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWt06F15M.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuU6F.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtE6F15M.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWvU6F15M.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtU6F15M.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuk6F15M.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWu06F15M.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWxU6F15M.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqW106F15M.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtk6F15M.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWt06F15M.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuU6F.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtE6F15M.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWvU6F15M.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtU6F15M.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuk6F15M.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWu06F15M.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWxU6F15M.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqW106F15M.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWtk6F15M.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWt06F15M.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: italic;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memtYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWqWuU6F.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSKmu1aB.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSumu1aB.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSOmu1aB.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSymu1aB.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS2mu1aB.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTVOmu1aB.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTUGmu1aB.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSCmu1aB.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSGmu1aB.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 300;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS-muw.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSKmu1aB.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSumu1aB.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSOmu1aB.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSymu1aB.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS2mu1aB.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTVOmu1aB.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTUGmu1aB.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSCmu1aB.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 400;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSGmu1aB.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
   font-weight: 400;
-  font-stretch: normal;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS-muw.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSKmu1aB.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSumu1aB.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSOmu1aB.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSymu1aB.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS2mu1aB.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTVOmu1aB.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTUGmu1aB.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSCmu1aB.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSGmu1aB.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 500;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS-muw.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSKmu1aB.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSumu1aB.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSOmu1aB.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSymu1aB.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memQYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWq8tWZ0Pw86hd0Rk8ZkaVQ.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS2mu1aB.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
 }
+/* math */
 @font-face {
   font-family: 'Open Sans';
-  font-style: italic;
-  font-weight: 500;
-  font-stretch: normal;
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memQYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWq8tWZ0Pw86hd0Rk_RkaVQ.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTVOmu1aB.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
 }
+/* symbols */
 @font-face {
   font-family: 'Open Sans';
-  font-style: italic;
+  font-style: normal;
   font-weight: 600;
-  font-stretch: normal;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memQYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWq8tWZ0Pw86hd0RkxhjaVQ.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTUGmu1aB.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
 }
+/* vietnamese */
 @font-face {
   font-family: 'Open Sans';
-  font-style: italic;
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSCmu1aB.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSGmu1aB.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 600;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS-muw.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
   font-weight: 700;
-  font-stretch: normal;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memQYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWq8tWZ0Pw86hd0RkyFjaVQ.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSKmu1aB.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
 }
+/* cyrillic */
 @font-face {
   font-family: 'Open Sans';
-  font-style: italic;
-  font-weight: 800;
-  font-stretch: normal;
+  font-style: normal;
+  font-weight: 700;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memQYaGs126MiZpBA-UFUIcVXSCEkx2cmqvXlWq8tWZ0Pw86hd0Rk0ZjaVQ.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSumu1aB.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
 }
+/* greek-ext */
 @font-face {
   font-family: 'Open Sans';
   font-style: normal;
-  font-weight: 300;
-  font-stretch: normal;
+  font-weight: 700;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memSYaGs126MiZpBA-UvWbX2vVnXBbObj2OVZyOOSr4dVJWUgsiH0C4k.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSOmu1aB.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
 }
+/* greek */
 @font-face {
   font-family: 'Open Sans';
   font-style: normal;
-  font-weight: 400;
-  font-stretch: normal;
+  font-weight: 700;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memSYaGs126MiZpBA-UvWbX2vVnXBbObj2OVZyOOSr4dVJWUgsjZ0C4k.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSymu1aB.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
 }
+/* hebrew */
 @font-face {
   font-family: 'Open Sans';
   font-style: normal;
-  font-weight: 500;
-  font-stretch: normal;
+  font-weight: 700;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memSYaGs126MiZpBA-UvWbX2vVnXBbObj2OVZyOOSr4dVJWUgsjr0C4k.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS2mu1aB.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
 }
+/* math */
 @font-face {
   font-family: 'Open Sans';
   font-style: normal;
-  font-weight: 600;
-  font-stretch: normal;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTVOmu1aB.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTUGmu1aB.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 700;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSCmu1aB.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 700;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memSYaGs126MiZpBA-UvWbX2vVnXBbObj2OVZyOOSr4dVJWUgsgH1y4k.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSGmu1aB.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
 }
+/* latin */
 @font-face {
   font-family: 'Open Sans';
   font-style: normal;
   font-weight: 700;
-  font-stretch: normal;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS-muw.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
   font-display: swap;
-  src: url(fonts/memSYaGs126MiZpBA-UvWbX2vVnXBbObj2OVZyOOSr4dVJWUgsg-1y4k.woff) format('woff');
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSKmu1aB.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
 }
+/* cyrillic */
 @font-face {
   font-family: 'Open Sans';
   font-style: normal;
   font-weight: 800;
-  font-stretch: normal;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSumu1aB.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSOmu1aB.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSymu1aB.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* hebrew */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS2mu1aB.woff2) format('woff2');
+  unicode-range: U+0590-05FF, U+200C-2010, U+20AA, U+25CC, U+FB1D-FB4F;
+}
+/* math */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTVOmu1aB.woff2) format('woff2');
+  unicode-range: U+0302-0303, U+0305, U+0307-0308, U+0330, U+0391-03A1, U+03A3-03A9, U+03B1-03C9, U+03D1, U+03D5-03D6, U+03F0-03F1, U+03F4-03F5, U+2034-2037, U+2057, U+20D0-20DC, U+20E1, U+20E5-20EF, U+2102, U+210A-210E, U+2110-2112, U+2115, U+2119-211D, U+2124, U+2128, U+212C-212D, U+212F-2131, U+2133-2138, U+213C-2140, U+2145-2149, U+2190, U+2192, U+2194-21AE, U+21B0-21E5, U+21F1-21F2, U+21F4-2211, U+2213-2214, U+2216-22FF, U+2308-230B, U+2310, U+2319, U+231C-2321, U+2336-237A, U+237C, U+2395, U+239B-23B6, U+23D0, U+23DC-23E1, U+2474-2475, U+25AF, U+25B3, U+25B7, U+25BD, U+25C1, U+25CA, U+25CC, U+25FB, U+266D-266F, U+27C0-27FF, U+2900-2AFF, U+2B0E-2B11, U+2B30-2B4C, U+2BFE, U+FF5B, U+FF5D, U+1D400-1D7FF, U+1EE00-1EEFF;
+}
+/* symbols */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTUGmu1aB.woff2) format('woff2');
+  unicode-range: U+0001-000C, U+000E-001F, U+007F-009F, U+20DD-20E0, U+20E2-20E4, U+2150-218F, U+2190, U+2192, U+2194-2199, U+21AF, U+21E6-21F0, U+21F3, U+2218-2219, U+2299, U+22C4-22C6, U+2300-243F, U+2440-244A, U+2460-24FF, U+25A0-27BF, U+2800-28FF, U+2921-2922, U+2981, U+29BF, U+29EB, U+2B00-2BFF, U+4DC0-4DFF, U+FFF9-FFFB, U+10140-1018E, U+10190-1019C, U+101A0, U+101D0-101FD, U+102E0-102FB, U+10E60-10E7E, U+1D2C0-1D2D3, U+1D2E0-1D37F, U+1F000-1F0FF, U+1F100-1F1AD, U+1F1E6-1F1FF, U+1F30D-1F30F, U+1F315, U+1F31C, U+1F31E, U+1F320-1F32C, U+1F336, U+1F378, U+1F37D, U+1F382, U+1F393-1F39F, U+1F3A7-1F3A8, U+1F3AC-1F3AF, U+1F3C2, U+1F3C4-1F3C6, U+1F3CA-1F3CE, U+1F3D4-1F3E0, U+1F3ED, U+1F3F1-1F3F3, U+1F3F5-1F3F7, U+1F408, U+1F415, U+1F41F, U+1F426, U+1F43F, U+1F441-1F442, U+1F444, U+1F446-1F449, U+1F44C-1F44E, U+1F453, U+1F46A, U+1F47D, U+1F4A3, U+1F4B0, U+1F4B3, U+1F4B9, U+1F4BB, U+1F4BF, U+1F4C8-1F4CB, U+1F4D6, U+1F4DA, U+1F4DF, U+1F4E3-1F4E6, U+1F4EA-1F4ED, U+1F4F7, U+1F4F9-1F4FB, U+1F4FD-1F4FE, U+1F503, U+1F507-1F50B, U+1F50D, U+1F512-1F513, U+1F53E-1F54A, U+1F54F-1F5FA, U+1F610, U+1F650-1F67F, U+1F687, U+1F68D, U+1F691, U+1F694, U+1F698, U+1F6AD, U+1F6B2, U+1F6B9-1F6BA, U+1F6BC, U+1F6C6-1F6CF, U+1F6D3-1F6D7, U+1F6E0-1F6EA, U+1F6F0-1F6F3, U+1F6F7-1F6FC, U+1F700-1F7FF, U+1F800-1F80B, U+1F810-1F847, U+1F850-1F859, U+1F860-1F887, U+1F890-1F8AD, U+1F8B0-1F8B1, U+1F900-1F90B, U+1F93B, U+1F946, U+1F984, U+1F996, U+1F9E9, U+1FA00-1FA6F, U+1FA70-1FA7C, U+1FA80-1FA88, U+1FA90-1FABD, U+1FABF-1FAC5, U+1FACE-1FADB, U+1FAE0-1FAE8, U+1FAF0-1FAF8, U+1FB00-1FBFF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSCmu1aB.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTSGmu1aB.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Open Sans';
+  font-style: normal;
+  font-weight: 800;
+  font-stretch: 100%;
+  font-display: swap;
+  src: url(fonts/memvYaGs126MiZpBA-UvWbX2vVnXBbObj2OVTS-muw.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvZlMIXxw.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvQlMIXxw.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvYlMIXxw.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvXlMIXxw.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvblMIXxw.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 400;
   font-display: swap;
-  src: url(fonts/memSYaGs126MiZpBA-UvWbX2vVnXBbObj2OVZyOOSr4dVJWUgshZ1y4k.woff) format('woff');
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvalMIXxw.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
 }
+/* latin */
 @font-face {
   font-family: 'Source Code Pro';
   font-style: italic;
   font-weight: 400;
   font-display: swap;
-  src: url(fonts/HI_jiYsKILxRpg3hIP6sJ7fM7PqlOPHYvDP_W9O7GQTTbI1rSg.woff) format('woff');
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvUlMI.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvZlMIXxw.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvQlMIXxw.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
 }
+/* greek-ext */
 @font-face {
   font-family: 'Source Code Pro';
   font-style: italic;
   font-weight: 600;
   font-display: swap;
-  src: url(fonts/HI_jiYsKILxRpg3hIP6sJ7fM7PqlOPHYvDP_W9O7GQTTsoprSg.woff) format('woff');
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvYlMIXxw.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvXlMIXxw.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvblMIXxw.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvalMIXxw.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: italic;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_QiYsKILxRpg3hIP6sJ7fM7PqlONvUlMI.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlMOvWjMY.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlOevWjMY.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlMevWjMY.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlPuvWjMY.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
 }
+/* vietnamese */
 @font-face {
   font-family: 'Source Code Pro';
   font-style: normal;
   font-weight: 400;
   font-display: swap;
-  src: url(fonts/HI_diYsKILxRpg3hIP6sJ7fM7PqPMcMnZFqUwX28DMyQhM0.woff) format('woff');
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlMuvWjMY.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlM-vWjMY.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
+}
+/* latin */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 400;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlPevW.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
+}
+/* cyrillic-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlMOvWjMY.woff2) format('woff2');
+  unicode-range: U+0460-052F, U+1C80-1C88, U+20B4, U+2DE0-2DFF, U+A640-A69F, U+FE2E-FE2F;
+}
+/* cyrillic */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlOevWjMY.woff2) format('woff2');
+  unicode-range: U+0301, U+0400-045F, U+0490-0491, U+04B0-04B1, U+2116;
+}
+/* greek-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlMevWjMY.woff2) format('woff2');
+  unicode-range: U+1F00-1FFF;
+}
+/* greek */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlPuvWjMY.woff2) format('woff2');
+  unicode-range: U+0370-0377, U+037A-037F, U+0384-038A, U+038C, U+038E-03A1, U+03A3-03FF;
+}
+/* vietnamese */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlMuvWjMY.woff2) format('woff2');
+  unicode-range: U+0102-0103, U+0110-0111, U+0128-0129, U+0168-0169, U+01A0-01A1, U+01AF-01B0, U+0300-0301, U+0303-0304, U+0308-0309, U+0323, U+0329, U+1EA0-1EF9, U+20AB;
+}
+/* latin-ext */
+@font-face {
+  font-family: 'Source Code Pro';
+  font-style: normal;
+  font-weight: 600;
+  font-display: swap;
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlM-vWjMY.woff2) format('woff2');
+  unicode-range: U+0100-02AF, U+0304, U+0308, U+0329, U+1E00-1E9F, U+1EF2-1EFF, U+2020, U+20A0-20AB, U+20AD-20C0, U+2113, U+2C60-2C7F, U+A720-A7FF;
 }
+/* latin */
 @font-face {
   font-family: 'Source Code Pro';
   font-style: normal;
   font-weight: 600;
   font-display: swap;
-  src: url(fonts/HI_diYsKILxRpg3hIP6sJ7fM7PqPMcMnZFqUwX28DBKXhM0.woff) format('woff');
+  src: url(fonts/HI_SiYsKILxRpg3hIP6sJ7fM7PqlPevW.woff2) format('woff2');
+  unicode-range: U+0000-00FF, U+0131, U+0152-0153, U+02BB-02BC, U+02C6, U+02DA, U+02DC, U+0304, U+0308, U+0329, U+2000-206F, U+2074, U+20AC, U+2122, U+2191, U+2193, U+2212, U+2215, U+FEFF, U+FFFD;
 }
diff --git a/main/deps/bootstrap-5.3.1/fonts/07d40e985ad7c747025dabb9f22142c4.woff2 b/main/deps/bootstrap-5.3.1/fonts/07d40e985ad7c747025dabb9f22142c4.woff2
new file mode 100644
index 00000000..a45f4778
Binary files /dev/null and b/main/deps/bootstrap-5.3.1/fonts/07d40e985ad7c747025dabb9f22142c4.woff2 differ
diff --git a/main/deps/bootstrap-5.3.1/fonts/1Ptug8zYS_SKggPNyC0ITw.woff2 b/main/deps/bootstrap-5.3.1/fonts/1Ptug8zYS_SKggPNyC0ITw.woff2
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diff --git a/main/index.html b/main/index.html
index 09becfd3..ed4989f1 100644
--- a/main/index.html
+++ b/main/index.html
@@ -27,7 +27,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -45,16 +45,6 @@
 <li class="nav-item">
   <a class="nav-link" href="news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul>
 <form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off">
diff --git a/main/news/index.html b/main/news/index.html
index 39bd0b71..43321d05 100644
--- a/main/news/index.html
+++ b/main/news/index.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
 <li class="active nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
@@ -58,15 +48,15 @@
     </div>
 
     <div class="section level2">
-<h2 class="pkg-version" data-toc-text="0.1.6.9009" id="tealmoduleshermes-0169009">teal.modules.hermes 0.1.6.9009<a class="anchor" aria-label="anchor" href="#tealmoduleshermes-0169009"></a></h2>
+<h2 class="pkg-version" data-toc-text="0.1.6.9010" id="tealmoduleshermes-0169010">teal.modules.hermes 0.1.6.9010<a class="anchor" aria-label="anchor" href="#tealmoduleshermes-0169010"></a></h2>
 <div class="section level4">
-<h4 id="miscellaneous-0-1-6-9009">Miscellaneous<a class="anchor" aria-label="anchor" href="#miscellaneous-0-1-6-9009"></a></h4>
+<h4 id="miscellaneous-0-1-6-9010">Miscellaneous<a class="anchor" aria-label="anchor" href="#miscellaneous-0-1-6-9010"></a></h4>
 <ul><li>Added placeholders for <code>assaySpec</code>, <code>adtteSpec</code> and <code>geneSpec</code> inputs when no option is selected.</li>
 <li>Disabled the select input for <code>assaySpec</code> and <code>adtteSpec</code> when there are no options available.</li>
 <li>For module developers: The module gets <code>teal_data</code> object in the UI and <code>reactive(&lt;teal_data&gt;)</code> in the server</li>
 </ul></div>
 <div class="section level4">
-<h4 id="enhancements-0-1-6-9009">Enhancements<a class="anchor" aria-label="anchor" href="#enhancements-0-1-6-9009"></a></h4>
+<h4 id="enhancements-0-1-6-9010">Enhancements<a class="anchor" aria-label="anchor" href="#enhancements-0-1-6-9010"></a></h4>
 <ul><li>Updated the documentation and vignettes with the new way of specifying data for <code><a href="https://insightsengineering.github.io/teal/latest-tag/reference/init.html" class="external-link">teal::init()</a></code>. The <code>data</code> argument accepts <code>teal_data</code> object.</li>
 </ul></div>
 </div>
diff --git a/main/pkgdown.yml b/main/pkgdown.yml
index 5f975663..14fd1c1e 100644
--- a/main/pkgdown.yml
+++ b/main/pkgdown.yml
@@ -3,7 +3,7 @@ pkgdown: 2.0.7
 pkgdown_sha: ~
 articles:
   Getting_Started: Getting_Started.html
-last_built: 2024-04-02T14:58Z
+last_built: 2024-04-08T16:08Z
 urls:
   reference: https://insightsengineering.github.io/teal.modules.hermes/reference
   article: https://insightsengineering.github.io/teal.modules.hermes/articles
diff --git a/main/pull_request_template.html b/main/pull_request_template.html
index 6fb94014..8ce83de6 100644
--- a/main/pull_request_template.html
+++ b/main/pull_request_template.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -27,16 +27,6 @@
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diff --git a/main/reference/adtteSpecInput.html b/main/reference/adtteSpecInput.html
index 376383f7..d976bd56 100644
--- a/main/reference/adtteSpecInput.html
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@@ -12,7 +12,7 @@
     
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diff --git a/main/reference/adtteSpecServer.html b/main/reference/adtteSpecServer.html
index 338360f5..4dac3445 100644
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diff --git a/main/reference/assaySpecInput.html b/main/reference/assaySpecInput.html
index 5df9f41a..c48a88ff 100644
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diff --git a/main/reference/assaySpecServer.html b/main/reference/assaySpecServer.html
index fb5adeab..3c2a88fb 100644
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diff --git a/main/reference/assert_adtte_vars.html b/main/reference/assert_adtte_vars.html
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diff --git a/main/reference/assert_summary_funs.html b/main/reference/assert_summary_funs.html
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diff --git a/main/reference/assertion_arguments.html b/main/reference/assertion_arguments.html
index 67ed6452..4557e8fd 100644
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diff --git a/main/reference/assertions.html b/main/reference/assertions.html
index d90521c1..f2729c3e 100644
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diff --git a/main/reference/check_reactive.html b/main/reference/check_reactive.html
index 63d3b032..20f33ff6 100644
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     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
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diff --git a/main/reference/check_tag.html b/main/reference/check_tag.html
index e362e443..75e08024 100644
--- a/main/reference/check_tag.html
+++ b/main/reference/check_tag.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
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         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/experimentSpecInput.html b/main/reference/experimentSpecInput.html
index 5e554d97..a7edd135 100644
--- a/main/reference/experimentSpecInput.html
+++ b/main/reference/experimentSpecInput.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/experimentSpecServer.html b/main/reference/experimentSpecServer.html
index c91d94b3..d16cb64d 100644
--- a/main/reference/experimentSpecServer.html
+++ b/main/reference/experimentSpecServer.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/function_arguments.html b/main/reference/function_arguments.html
index 8f6d7d6f..6d6ad449 100644
--- a/main/reference/function_arguments.html
+++ b/main/reference/function_arguments.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/geneSpecInput.html b/main/reference/geneSpecInput.html
index 1080b22c..ce33db3d 100644
--- a/main/reference/geneSpecInput.html
+++ b/main/reference/geneSpecInput.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
@@ -193,7 +183,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span>     &lt;/div&gt;</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>   &lt;/div&gt;</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> &lt;/div&gt;</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> &lt;div data-display-if="input.genes &amp;amp;&amp;amp; input.genes.length &amp;gt; 1" data-ns-prefix="my_genes-"&gt;</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> &lt;div class="shiny-panel-conditional" data-display-if="input.genes &amp;amp;&amp;amp; input.genes.length &amp;gt; 1" data-ns-prefix="my_genes-"&gt;</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>   &lt;div class="form-group shiny-input-container"&gt;</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>     &lt;label class="control-label" id="my_genes-fun_name-label" for="my_genes-fun_name"&gt;Please select function&lt;/label&gt;</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>     &lt;div&gt;</span>
diff --git a/main/reference/geneSpecServer.html b/main/reference/geneSpecServer.html
index 0b279725..b002a0cf 100644
--- a/main/reference/geneSpecServer.html
+++ b/main/reference/geneSpecServer.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/h_assign_to_group_list.html b/main/reference/h_assign_to_group_list.html
index 028aaaa3..187c2395 100644
--- a/main/reference/h_assign_to_group_list.html
+++ b/main/reference/h_assign_to_group_list.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/h_collapse_levels.html b/main/reference/h_collapse_levels.html
index d4b5d3d1..92eced9c 100644
--- a/main/reference/h_collapse_levels.html
+++ b/main/reference/h_collapse_levels.html
@@ -16,7 +16,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
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diff --git a/main/reference/h_extract_words.html b/main/reference/h_extract_words.html
index 0c3a36c0..0e68c467 100644
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diff --git a/main/reference/h_gene_data.html b/main/reference/h_gene_data.html
index 35a306b6..aa492f83 100644
--- a/main/reference/h_gene_data.html
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diff --git a/main/reference/h_km_mae_to_adtte.html b/main/reference/h_km_mae_to_adtte.html
index 34c1a0bb..f8f27396 100644
--- a/main/reference/h_km_mae_to_adtte.html
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@@ -12,7 +12,7 @@
     
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diff --git a/main/reference/h_order_genes.html b/main/reference/h_order_genes.html
index 1a11c572..b11da3db 100644
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diff --git a/main/reference/h_parse_genes.html b/main/reference/h_parse_genes.html
index 8b59239c..99822ea5 100644
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@@ -14,7 +14,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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diff --git a/main/reference/h_update_gene_selection.html b/main/reference/h_update_gene_selection.html
index e03521f6..91fe45b1 100644
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@@ -16,7 +16,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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diff --git a/main/reference/heatmap_plot.html b/main/reference/heatmap_plot.html
index fdfdba8d..9aa2d375 100644
--- a/main/reference/heatmap_plot.html
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@@ -12,7 +12,7 @@
     
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     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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diff --git a/main/reference/include_css_files.html b/main/reference/include_css_files.html
index c8cd44be..2abca725 100644
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     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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index 0d22de1c..b1f2e82f 100644
--- a/main/reference/include_js_files.html
+++ b/main/reference/include_js_files.html
@@ -14,7 +14,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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diff --git a/main/reference/index.html b/main/reference/index.html
index a4f2be4d..2caa87a7 100644
--- a/main/reference/index.html
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@@ -10,7 +10,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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diff --git a/main/reference/is_blank.html b/main/reference/is_blank.html
index 3c6c7b05..6222859c 100644
--- a/main/reference/is_blank.html
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@@ -14,7 +14,7 @@
     
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diff --git a/main/reference/module_arguments.html b/main/reference/module_arguments.html
index 9153f5a9..5c45ea3a 100644
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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diff --git a/main/reference/multiSampleVarSpecServer.html b/main/reference/multiSampleVarSpecServer.html
index f1f4e7aa..72a84989 100644
--- a/main/reference/multiSampleVarSpecServer.html
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@@ -14,7 +14,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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@@ -31,16 +31,6 @@
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diff --git a/main/reference/rADTTE.html b/main/reference/rADTTE.html
index 00ca26e7..efec216b 100644
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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@@ -27,16 +27,6 @@
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diff --git a/main/reference/sampleVarSpecInput.html b/main/reference/sampleVarSpecInput.html
index 83f917fd..8064d2cb 100644
--- a/main/reference/sampleVarSpecInput.html
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@@ -12,7 +12,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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diff --git a/main/reference/sampleVarSpecServer.html b/main/reference/sampleVarSpecServer.html
index 894b7991..6c7318da 100644
--- a/main/reference/sampleVarSpecServer.html
+++ b/main/reference/sampleVarSpecServer.html
@@ -12,7 +12,7 @@
     
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
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     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
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diff --git a/main/reference/teal.modules.hermes-package.html b/main/reference/teal.modules.hermes-package.html
index c28e9192..c5833371 100644
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+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
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 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
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diff --git a/main/reference/tm_g_barplot.html b/main/reference/tm_g_barplot.html
index fa448c6a..7af1736c 100644
--- a/main/reference/tm_g_barplot.html
+++ b/main/reference/tm_g_barplot.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
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diff --git a/main/reference/tm_g_boxplot.html b/main/reference/tm_g_boxplot.html
index 2e74826f..816a8b60 100644
--- a/main/reference/tm_g_boxplot.html
+++ b/main/reference/tm_g_boxplot.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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diff --git a/main/reference/tm_g_forest_tte.html b/main/reference/tm_g_forest_tte.html
index 4df60c57..bb75649c 100644
--- a/main/reference/tm_g_forest_tte.html
+++ b/main/reference/tm_g_forest_tte.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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diff --git a/main/reference/tm_g_km.html b/main/reference/tm_g_km.html
index ad413310..6b7c3e3c 100644
--- a/main/reference/tm_g_km.html
+++ b/main/reference/tm_g_km.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/tm_g_pca.html b/main/reference/tm_g_pca.html
index 646b572b..8d32ddb2 100644
--- a/main/reference/tm_g_pca.html
+++ b/main/reference/tm_g_pca.html
@@ -16,7 +16,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -33,16 +33,6 @@
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   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/tm_g_quality.html b/main/reference/tm_g_quality.html
index 1cc548a0..ee9d4d17 100644
--- a/main/reference/tm_g_quality.html
+++ b/main/reference/tm_g_quality.html
@@ -16,7 +16,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -33,16 +33,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
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diff --git a/main/reference/tm_g_scatterplot.html b/main/reference/tm_g_scatterplot.html
index da0759e0..62e49426 100644
--- a/main/reference/tm_g_scatterplot.html
+++ b/main/reference/tm_g_scatterplot.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
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   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
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-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
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diff --git a/main/reference/tm_g_volcanoplot.html b/main/reference/tm_g_volcanoplot.html
index b1194219..c39e96ba 100644
--- a/main/reference/tm_g_volcanoplot.html
+++ b/main/reference/tm_g_volcanoplot.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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diff --git a/main/reference/top_gene_plot.html b/main/reference/top_gene_plot.html
index c65753ad..49751c6a 100644
--- a/main/reference/top_gene_plot.html
+++ b/main/reference/top_gene_plot.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -29,16 +29,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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diff --git a/main/reference/validate_gene_spec.html b/main/reference/validate_gene_spec.html
index c85d1c05..7168e759 100644
--- a/main/reference/validate_gene_spec.html
+++ b/main/reference/validate_gene_spec.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
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   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
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-<!-- end dropdown for versions -->
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         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/reference/validate_n_levels.html b/main/reference/validate_n_levels.html
index 2ef89052..83cfbbfb 100644
--- a/main/reference/validate_n_levels.html
+++ b/main/reference/validate_n_levels.html
@@ -14,7 +14,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">teal.modules.hermes</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9009</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.1.6.9010</small>
 
     <div style="width: 140px; margin-left: 0.5rem;"> <small class="nav-text text-muted me-auto">part of</small> <img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/nest.png?raw=true" alt="NEST" style="height: 30px;"><a href="https://pharmaverse.org/" class="external-link"><img src="https://github.com/insightsengineering/hex-stickers/blob/main/PNG/pharmaverse.png?raw=true" alt="pharmaverse" style="height: 28px;"></a> </div>
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -31,16 +31,6 @@
 <li class="nav-item">
   <a class="nav-link" href="../news/index.html">Changelog</a>
 </li>
-<!-- start dropdown for versions --> <li class="nav-item dropdown">
-        <a href="#" class="nav-link dropdown-toggle"
-          data-bs-toggle="dropdown" role="button"
-          aria-expanded="false" aria-haspopup="true"
-          id="dropdown-versions">Versions</a> <div class="dropdown-menu" aria-labelledby="dropdown-versions"> <a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/main">main</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/latest-tag">latest-tag</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.6">v0.1.6</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.5">v0.1.5</a>
-<a class="dropdown-item" data-toggle="tooltip" title="" href="https://insightsengineering.github.io/teal.modules.hermes/v0.1.4">v0.1.4</a> </div></li>
-<!-- end dropdown for versions -->
       </ul><form class="form-inline my-2 my-lg-0" role="search">
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
diff --git a/main/search.json b/main/search.json
index c099d15c..d2c67881 100644
--- a/main/search.json
+++ b/main/search.json
@@ -1 +1 @@
-[{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"members, contributors, leaders pledge make participation community harassment-free experience everyone, regardless age, body size, visible invisible disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, caste, color, religion, sexual identity orientation. pledge act interact ways contribute open, welcoming, diverse, inclusive, healthy community.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes positive environment community include: Demonstrating empathy kindness toward people respectful differing opinions, viewpoints, experiences Giving gracefully accepting constructive feedback Accepting responsibility apologizing affected mistakes, learning experience Focusing best just us individuals, overall community Examples unacceptable behavior include: use sexualized language imagery, sexual attention advances kind Trolling, insulting derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical email address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"enforcement-responsibilities","dir":"","previous_headings":"","what":"Enforcement Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Community leaders responsible clarifying enforcing standards acceptable behavior take appropriate fair corrective action response behavior deem inappropriate, threatening, offensive, harmful. Community leaders right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, communicate reasons moderation decisions appropriate.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within community spaces, also applies individual officially representing community public spaces. Examples representing community include using official e-mail address, posting via official social media account, acting appointed representative online offline event.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported community leaders responsible enforcement [INSERT CONTACT METHOD]. complaints reviewed investigated promptly fairly. community leaders obligated respect privacy security reporter incident.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"enforcement-guidelines","dir":"","previous_headings":"","what":"Enforcement Guidelines","title":"Contributor Covenant Code of Conduct","text":"Community leaders follow Community Impact Guidelines determining consequences action deem violation Code Conduct:","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"id_1-correction","dir":"","previous_headings":"Enforcement Guidelines","what":"1. Correction","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Use inappropriate language behavior deemed unprofessional unwelcome community. Consequence: private, written warning community leaders, providing clarity around nature violation explanation behavior inappropriate. public apology may requested.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"id_2-warning","dir":"","previous_headings":"Enforcement Guidelines","what":"2. Warning","title":"Contributor Covenant Code of Conduct","text":"Community Impact: violation single incident series actions. Consequence: warning consequences continued behavior. interaction people involved, including unsolicited interaction enforcing Code Conduct, specified period time. includes avoiding interactions community spaces well external channels like social media. Violating terms may lead temporary permanent ban.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"id_3-temporary-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"3. Temporary Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: serious violation community standards, including sustained inappropriate behavior. Consequence: temporary ban sort interaction public communication community specified period time. public private interaction people involved, including unsolicited interaction enforcing Code Conduct, allowed period. Violating terms may lead permanent ban.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"id_4-permanent-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"4. Permanent Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Demonstrating pattern violation community standards, including sustained inappropriate behavior, harassment individual, aggression toward disparagement classes individuals. Consequence: permanent ban sort public interaction within community.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 2.1, available https://www.contributor-covenant.org/version/2/1/code_of_conduct.html. Community Impact Guidelines inspired Mozilla’s code conduct enforcement ladder. answers common questions code conduct, see FAQ https://www.contributor-covenant.org/faq. Translations available https://www.contributor-covenant.org/translations.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contribution Guidelines","title":"Contribution Guidelines","text":"🙏 Thank taking time contribute! input deeply valued, whether issue, pull request, even feedback, regardless size, content scope.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"table-of-contents","dir":"","previous_headings":"","what":"Table of contents","title":"Contribution Guidelines","text":"👶 Getting started 📔 Code Conduct 🗃 License 📜 Issues 🚩 Pull requests 💻 Coding guidelines 🏆 Recognition model ❓ Questions","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"getting-started","dir":"","previous_headings":"","what":"Getting started","title":"Contribution Guidelines","text":"Please refer project documentation brief introduction. Please also see articles within project documentation additional information.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Contribution Guidelines","text":"Code Conduct governs project. Participants contributors expected follow rules outlined therein.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"license","dir":"","previous_headings":"","what":"License","title":"Contribution Guidelines","text":"contributions covered project’s license.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"issues","dir":"","previous_headings":"","what":"Issues","title":"Contribution Guidelines","text":"use GitHub track issues, feature requests, bugs. submitting new issue, please check issue already reported. issue already exists, please upvote existing issue 👍. new feature requests, please elaborate context benefit feature users, developers, relevant personas.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"github-flow","dir":"","previous_headings":"Pull requests","what":"GitHub Flow","title":"Contribution Guidelines","text":"repository uses GitHub Flow model collaboration. submit pull request: Create branch Please see branch naming convention . don’t write access repository, please fork . Make changes Make sure code passes checks imposed GitHub Actions well documented well tested unit tests sufficiently covering changes introduced Create pull request (PR) pull request description, please link relevant issue (), provide detailed description change, include assumptions. Address review comments, Post approval Merge PR write access. Otherwise, reviewer merge PR behalf. Pat back Congratulations! 🎉 now official contributor project! grateful contribution.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"branch-naming-convention","dir":"","previous_headings":"Pull requests","what":"Branch naming convention","title":"Contribution Guidelines","text":"Suppose changes related current issue current project; please name branch follows: <issue_id>_<short_description>. Please use underscore (_) delimiter word separation. example, 420_fix_ui_bug suitable branch name change resolving UI-related bug reported issue number 420 current project. change affects multiple repositories, please name branches follows: <issue_id>_<issue_repo>_<short description>. example, 69_awesomeproject_fix_spelling_error reference issue 69 reported project awesomeproject aims resolve one spelling errors multiple (likely related) repositories.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"monorepo-and-stageddependencies","dir":"","previous_headings":"Pull requests","what":"monorepo and staged.dependencies","title":"Contribution Guidelines","text":"Sometimes might need change upstream dependent package(s) able submit meaningful change. using staged.dependencies functionality simulate monorepo behavior. dependency configuration already specified project’s staged_dependencies.yaml file. need name feature branches appropriately. exception branch naming convention described . Please refer staged.dependencies package documentation details.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"coding-guidelines","dir":"","previous_headings":"","what":"Coding guidelines","title":"Contribution Guidelines","text":"repository follows unified processes standards adopted maintainers ensure software development carried consistently within teams cohesively across repositories.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"style-guide","dir":"","previous_headings":"Coding guidelines","what":"Style guide","title":"Contribution Guidelines","text":"repository follows standard tidyverse style guide uses lintr lint checks. Customized lint configurations available repository’s .lintr file.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"dependency-management","dir":"","previous_headings":"Coding guidelines","what":"Dependency management","title":"Contribution Guidelines","text":"Lightweight right weight. repository follows tinyverse recommedations limiting dependencies minimum.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"dependency-version-management","dir":"","previous_headings":"Coding guidelines","what":"Dependency version management","title":"Contribution Guidelines","text":"code compatible (!) historical versions given dependenct package, required specify minimal version DESCRIPTION file. particular: development version requires (imports) development version another package - required put abc (>= 1.2.3.9000).","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"r--package-versions","dir":"","previous_headings":"Coding guidelines > Recommended development environment & tools","what":"R & package versions","title":"Contribution Guidelines","text":"continuously test packages newest R version along recent dependencies CRAN BioConductor. recommend working environment also set way. can find details R version packages used R CMD check GitHub Action execution log - step prints R sessionInfo(). discover bugs older R versions older set dependencies, please create relevant bug reports.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"pre-commit","dir":"","previous_headings":"Coding guidelines > Recommended development environment & tools","what":"pre-commit","title":"Contribution Guidelines","text":"highly recommend use pre-commit tool combined R hooks pre-commit execute checks committing pushing changes. Pre-commit hooks already available repository’s .pre-commit-config.yaml file.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"recognition-model","dir":"","previous_headings":"","what":"Recognition model","title":"Contribution Guidelines","text":"mentioned previously, contributions deeply valued appreciated. contribution data available part repository insights, recognize significant contribution hence add contributor package authors list, following rules enforced: Minimum 5% lines code authored* (determined git blame query) top 5 contributors terms number commits lines added lines removed* *Excluding auto-generated code, including limited roxygen comments renv.lock files. package maintainer also reserves right adjust criteria recognize contributions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/CONTRIBUTING.html","id":"questions","dir":"","previous_headings":"","what":"Questions","title":"Contribution Guidelines","text":"questions regarding contribution guidelines, please contact package/repository maintainer.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/SECURITY.html","id":"reporting-security-issues","dir":"","previous_headings":"","what":"Reporting Security Issues","title":"Security Policy","text":"believe found security vulnerability repositories organization, please report us coordinated disclosure. Please report security vulnerabilities public GitHub issues, discussions, pull requests. Instead, please send email vulnerability.management[@]roche.com. Please include much information listed can help us better understand resolve issue: type issue (e.g., buffer overflow, SQL injection, cross-site scripting) Full paths source file(s) related manifestation issue location affected source code (tag/branch/commit direct URL) special configuration required reproduce issue Step--step instructions reproduce issue Proof--concept exploit code (possible) Impact issue, including attacker might exploit issue information help us triage report quickly.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/SECURITY.html","id":"data-security-standards-dss","dir":"","previous_headings":"","what":"Data Security Standards (DSS)","title":"Security Policy","text":"Please make sure reporting issues form bug, feature, pull request, sensitive information PII, PHI, PCI completely removed text attachments, including pictures videos.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/articles/Getting_Started.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Getting Started","text":"teal.modules.hermes package implementing number teal modules exploration RNA-sequencing counts data. addition predefined modules, teal.modules.hermes enables quick easy ad-hoc module creation.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/articles/Getting_Started.html","id":"ad-hoc-module-example","dir":"Articles","previous_headings":"","what":"Ad-hoc module example","title":"Getting Started","text":"Let’s assume function awesome_plot() takes count matrix makes awesome plot . Now like make Shiny app can filter patients, samples, select experiment MultiAssayExperiment (MAE), select count matrix experiment, etc. Nothing easier teal.modules.hermes! show quickly spin UI, server put together nice little app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/articles/Getting_Started.html","id":"ui-function","dir":"Articles","previous_headings":"Ad-hoc module example","what":"UI function","title":"Getting Started","text":"teal.modules.hermes provide modules make experiment assay selection super easy, see UI part:","code":"ui <- function(id, mae_name) {   ns <- NS(id)    teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = plotOutput(ns(\"awesome_plot\"))   ) }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/articles/Getting_Started.html","id":"server-function","dir":"Articles","previous_headings":"Ad-hoc module example","what":"Server function","title":"Getting Started","text":"Similarly server use modules, call awesome plotting function.","code":"srv <- function(input,                 output,                 session,                 data,                 filter_panel_api,                 mae_name) {   output$encoding_ui <- renderUI({     tags$div(       experimentSpecInput(session$ns(\"experiment\"), data, mae_name),       assaySpecInput(session$ns(\"assay\"))     )   })   experiment <- experimentSpecServer(     \"experiment\",     data = data,     filter_panel_api = filter_panel_api,     mae_name = mae_name,     name_annotation = NULL # If you have a gene name column in your rowData, can specify here.   )   assay <- assaySpecServer(\"assay\", experiment$assays)   output$awesome_plot <- renderPlot({     data <- experiment$data()     assay <- assay()     req(assay %in% SummarizedExperiment::assayNames(data))     counts <- SummarizedExperiment::assay(data, assay)     df <- data.frame(gene = rownames(counts), counts = rowSums(counts))     df <- na.omit(df[order(df$counts, decreasing = TRUE), ])     df$gene <- factor(df$gene, levels = df$gene)     df <- df[1:10, ]     ggplot(df, aes(x = gene, y = counts)) +       geom_col() +       theme(axis.text.x = element_text(angle = 90))   }) }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/articles/Getting_Started.html","id":"app-function","dir":"Articles","previous_headings":"Ad-hoc module example","what":"App function","title":"Getting Started","text":"Now let’s assume want spin app MAE.","code":"awesome_app <- function(mae, label = \"My awesome app\") {   mae_name <- \"MAE\"   data <- teal_data(MAE = hermes::lapply(mae, hermes::HermesData))   app <- init(     data = data,     modules = teal::modules(       module(         label = label,         server = srv,         server_args = list(mae_name = mae_name),         ui = ui,         ui_args = list(mae_name = mae_name),         datanames = mae_name       )     )   )   shinyApp(app$ui, app$server) }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/articles/Getting_Started.html","id":"testing-it","dir":"Articles","previous_headings":"Ad-hoc module example","what":"Testing it","title":"Getting Started","text":"test :","code":"awesome_app(hermes::multi_assay_experiment)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Daniel Sabanés Bové. Author, maintainer. Nikolas Burkoff. Author. Dinakar Kulkarni. Author. Konrad Pagacz. Author. Namrata Bhatia. Author. Dawid Kaledkowski. Author. Pawel Rucki. Author. Jeff Luong. Author. Stefanie Bienert. Author. Haocheng Li. Author. Lyndsee Midori Zhang. Author. Sorin Voicu. Contributor. Benoit Falquet. Contributor. Mahmoud Hallal. Contributor. Tim Treis. Contributor. Vedha Viyash. Contributor. F. Hoffmann-La Roche AG. Copyright holder, funder.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Sabanés Bové D, Burkoff N, Kulkarni D, Pagacz K, Bhatia N, Kaledkowski D, Rucki P, Luong J, Bienert S, Li H, Zhang L (2024). teal.modules.hermes: RNA-Seq Analysis Modules Add Teal Application. R package version 0.1.6.9009,  https://github.com/insightsengineering/teal.modules.hermes/, https://insightsengineering.github.io/teal.modules.hermes/main/.","code":"@Manual{,   title = {teal.modules.hermes: RNA-Seq Analysis Modules to Add to a Teal Application},   author = {Daniel {Sabanés Bové} and Nikolas Burkoff and Dinakar Kulkarni and Konrad Pagacz and Namrata Bhatia and Dawid Kaledkowski and Pawel Rucki and Jeff Luong and Stefanie Bienert and Haocheng Li and Lyndsee Midori Zhang},   year = {2024},   note = {R package version 0.1.6.9009,  https://github.com/insightsengineering/teal.modules.hermes/},   url = {https://insightsengineering.github.io/teal.modules.hermes/main/}, }"},{"path":[]},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/index.html","id":"what-is-teal","dir":"","previous_headings":"What is what","what":"What is teal?","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"teal shiny-based interactive exploration framework analyzing clinical trials data. teal currently provides dynamic filtering facility diverse data viewers. teal shiny applications built using standard shiny modules. See teal page details.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/index.html","id":"what-is-hermes","dir":"","previous_headings":"What is what","what":"What is hermes?","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"hermes facilitates preprocessing, analyzing, reporting RNA-seq data. core functionality built BioConductor ecosystem, especially SummarizedExperiment class HermesData class inherits. See vignette details.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/index.html","id":"so-what-is-then-tealmoduleshermes","dir":"","previous_headings":"What is what","what":"So what is then teal.modules.hermes?","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"teal.modules.hermes provides teal modules (can used part teal app), interactive RNA-seq data analysis using hermes. heavily built BioConductor classes, particular MultiAssayExperiment (MAE) expected contain HermesData experiments.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"July 2023 insightsengineering packages available r-universe. See package vignettes browseVignettes(package = \"teal.modules.hermes\") usage package.","code":"# stable versions install.packages('teal.modules.hermes', repos = c('https://insightsengineering.r-universe.dev', 'https://cloud.r-project.org'))  # beta versions install.packages('teal.modules.hermes', repos = c('https://pharmaverse.r-universe.dev', 'https://cloud.r-project.org'))"},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/pull_request_template.html","id":null,"dir":"","previous_headings":"","what":"Pull Request","title":"Pull Request","text":"Fixes #nnn","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for ADTTE Specification — adtteSpecInput","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"defines input ADTTE specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"","code":"adtteSpecInput(inputId, label_paramcd = \"Select Endpoint\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"inputId (string) ID used call module input. label_paramcd (string) label endpoint (PARAMCD) selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for ADTTE Specification — adtteSpecServer","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"defines server part ADTTE specification. resulting data set binned_adtte_subset contains subset ADTTE selected time--event endpoint, joined together gene information extracted specified assay experiment, numeric factor columns. factor column created binning numeric column according quantile cutoffs specified probs.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"","code":"adtteSpecServer(   id,   data,   mae_name,   adtte_name,   adtte_vars,   experiment_data,   experiment_name,   assay,   genes,   probs )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. mae_name (string) name MAE data used teal module. adtte_name (string) name ADTTE dataset. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. experiment_data (reactive AnyHermesData) input experiment. experiment_name (reactive string) name input experiment. assay (reactive string) name assay. genes (reactive GeneSpec) gene specification. probs (reactive numeric) probabilities bin gene gene signature .","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"List following elements: binned_adtte_subset: reactive containing joined ADTTE gene data. gene_col: reactive containing string column name original numeric gene variable. gene_factor: string variable name binned gene data. time_unit: reactive string time unit current subset.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/adtteSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"","code":"ui <- function(id) {   ns <- NS(id)    teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = verbatimTextOutput(ns(\"summary\"))   ) }  server <- function(id, data, filter_panel_api) {   checkmate::assert_class(data, \"reactive\")   checkmate::assert_class(shiny::isolate(data()), \"teal_data\")   moduleServer(id, function(input, output, session) {     output$encoding_ui <- renderUI({       tags$div(         experimentSpecInput(session$ns(\"experiment\"), data, mae_name = \"MAE\"),         assaySpecInput(session$ns(\"assay\")),         geneSpecInput(session$ns(\"genes\"), funs = list(Mean = colMeans)),         adtteSpecInput(session$ns(\"adtte\"))       )     })     experiment <- experimentSpecServer(       \"experiment\",       data = data,       filter_panel_api = filter_panel_api,       mae_name = \"MAE\"     )     assay <- assaySpecServer(       \"assay\",       assays = experiment$assays     )     genes <- geneSpecServer(       \"genes\",       funs = list(Mean = colMeans),       gene_choices = experiment$genes     )     adtte <- adtteSpecServer(       \"adtte\",       data = data,       adtte_name = \"ADTTE\",       mae_name = \"MAE\",       adtte_vars = list(         aval = \"AVAL\",         avalu = \"AVALU\",         is_event = \"is_event\",         paramcd = \"PARAMCD\",         usubjid = \"USUBJID\"       ),       experiment_data = experiment$data,       experiment_name = experiment$name,       assay = assay,       genes = genes,       probs = reactive({         0.5       })     )     output$summary <- renderPrint({       binned_adtte_subset <- adtte$binned_adtte_subset()       summary(binned_adtte_subset)     })   }) }  my_app <- function() {   data <- teal_data()   data <- within(data, {     ADSL <- teal.data::rADSL     ADTTE <- teal.modules.hermes::rADTTE %>%       dplyr::mutate(is_event = .data$CNSR == 0)     MAE <- hermes::multi_assay_experiment   })   datanames <- c(\"ADSL\", \"ADTTE\", \"MAE\")   datanames(data) <- datanames   join_keys(data) <- default_cdisc_join_keys[datanames]    app <- init(     data = data,     modules = modules(       module(         label = \"adtteSpec example\",         server = server,         ui = ui,         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) }  if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Assay Specification — assaySpecInput","title":"Module Input for Assay Specification — assaySpecInput","text":"defines input assay specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Assay Specification — assaySpecInput","text":"","code":"assaySpecInput(inputId, label_assays = \"Select Assay\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Assay Specification — assaySpecInput","text":"inputId (string) ID used call module input. label_assays (string) label assay selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Assay Specification — assaySpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Assay Specification — assaySpecServer","title":"Module Server for Assay Specification — assaySpecServer","text":"defines server part assay specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Assay Specification — assaySpecServer","text":"","code":"assaySpecServer(id, assays, exclude_assays = character())"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Assay Specification — assaySpecServer","text":"id (string) shiny module id. assays (reactive character) available assays currently selected experiment. exclude_assays (character) names assays included choices teal module.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Assay Specification — assaySpecServer","text":"chosen assay reactive string.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assaySpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Assay Specification — assaySpecServer","text":"","code":"ui <- function(id) {   ns <- NS(id)   teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = textOutput(ns(\"result\"))   ) }  server <- function(id, data, filter_panel_api) {   moduleServer(id, module = function(input, output, session) {     output$encoding_ui <- renderUI({       tags$div(         experimentSpecInput(session$ns(\"experiment\"), data, \"MAE\"),         assaySpecInput(           session$ns(\"assay\"),           label_assays = \"Please choose assay\"         )       )     })     experiment <- experimentSpecServer(       id = \"experiment\",       data = data,       filter_panel_api = filter_panel_api,       mae_name = \"MAE\"     )     assay <- assaySpecServer(       \"assay\",       experiment$assays,       exclude_assays = c(\"counts\", \"cpm\", \"tpm\", \"bla\")     )     output$result <- renderPrint({       assay()     })   }) }  my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"assaySpec example\",         server = server,         ui = ui,         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_adtte_vars.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for ADTTE Variables — assert_adtte_vars","title":"Check for ADTTE Variables — assert_adtte_vars","text":"Check whether x list ADTTE variables.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_adtte_vars.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for ADTTE Variables — assert_adtte_vars","text":"","code":"assert_adtte_vars(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_adtte_vars.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for ADTTE Variables — assert_adtte_vars","text":"x object check.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_adtte_vars.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for ADTTE Variables — assert_adtte_vars","text":"","code":"assert_adtte_vars(list(aval = \"AV\", is_event = \"EV\", paramcd = \"PC\", usubjid = \"ID\", avalu = \"u\"))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_summary_funs.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for List of Summary Functions — assert_summary_funs","title":"Check for List of Summary Functions — assert_summary_funs","text":"Check whether x list summary functions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_summary_funs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for List of Summary Functions — assert_summary_funs","text":"","code":"assert_summary_funs(x, null.ok = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_summary_funs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for List of Summary Functions — assert_summary_funs","text":"x object check. null.ok (flag) whether x may also contain NULL, meaning user choice possible summary function applied.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assert_summary_funs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for List of Summary Functions — assert_summary_funs","text":"","code":"assert_summary_funs(list(mean = colMeans, raw = NULL), null.ok = TRUE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assertion_arguments.html","id":null,"dir":"Reference","previous_headings":"","what":"Standard Assertion Arguments — assertion_arguments","title":"Standard Assertion Arguments — assertion_arguments","text":"documentation function lists conventional arguments additional checkmate assertions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assertion_arguments.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Standard Assertion Arguments — assertion_arguments","text":"x object check. null.ok (flag) whether x may also NULL. .var.name (string) name checked object print assertions; defaults heuristic implemented checkmate::vname(). add (AssertCollection NULL) collection store assertion messages, see checkmate::AssertCollection. info (string) extra information included message testthat reporter, see testthat::expect_that(). label (string) name checked object print messages. Defaults heuristic implemented checkmate::vname().","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assertions.html","id":null,"dir":"Reference","previous_headings":"","what":"Additional Assertions for checkmate — assertions","title":"Additional Assertions for checkmate — assertions","text":"provide additional assertion functions can used together checkmate functions. described individual help pages linked .","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/assertions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Additional Assertions for checkmate — assertions","text":"Depending function prefix. assert_ functions return object invisibly successful, otherwise throw error message. check_ functions return TRUE successful, otherwise string error message. test_ functions just return TRUE FALSE.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_reactive.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for Reactive Input — check_reactive","title":"Check for Reactive Input — check_reactive","text":"Check whether x reactive input.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_reactive.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for Reactive Input — check_reactive","text":"","code":"check_reactive(x)  assert_reactive(x, .var.name = checkmate::vname(x), add = NULL)  test_reactive(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_reactive.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for Reactive Input — check_reactive","text":"x object check. .var.name (string) name checked object print assertions; defaults heuristic implemented checkmate::vname(). add (AssertCollection NULL) collection store assertion messages, see checkmate::AssertCollection.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_reactive.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for Reactive Input — check_reactive","text":"","code":"check_reactive(\"bla\") #> [1] FALSE check_reactive(reactive(\"bla\")) #> [1] TRUE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_tag.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for Shiny Tag — check_tag","title":"Check for Shiny Tag — check_tag","text":"Check whether x shiny tag.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_tag.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for Shiny Tag — check_tag","text":"","code":"check_tag(x, null.ok = FALSE)  assert_tag(x, null.ok = FALSE, .var.name = checkmate::vname(x), add = NULL)  test_tag(x, null.ok = FALSE)  expect_tag(x, null.ok = FALSE, info = NULL, label = vname(x))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_tag.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for Shiny Tag — check_tag","text":"x object check. null.ok (flag) whether x may also NULL. .var.name (string) name checked object print assertions; defaults heuristic implemented checkmate::vname(). add (AssertCollection NULL) collection store assertion messages, see checkmate::AssertCollection. info (string) extra information included message testthat reporter, see testthat::expect_that(). label (string) name checked object print messages. Defaults heuristic implemented checkmate::vname().","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/check_tag.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for Shiny Tag — check_tag","text":"","code":"check_tag(\"bla\") #> [1] \"Must be a 'shiny.tag' or NULL\" check_tag(NULL, null.ok = TRUE) #> [1] TRUE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Experiment Specification — experimentSpecInput","title":"Module Input for Experiment Specification — experimentSpecInput","text":"defines input experiment specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Experiment Specification — experimentSpecInput","text":"","code":"experimentSpecInput(   inputId,   data,   mae_name,   label_experiments = \"Select Experiment\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Experiment Specification — experimentSpecInput","text":"inputId (string) ID used call module input. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. mae_name (string) name MAE data used teal module. label_experiments (string) label experiment selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Experiment Specification — experimentSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Experiment Specification — experimentSpecServer","title":"Module Server for Experiment Specification — experimentSpecServer","text":"defines server part experiment specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Experiment Specification — experimentSpecServer","text":"","code":"experimentSpecServer(   id,   data,   filter_panel_api,   mae_name,   name_annotation = \"symbol\",   sample_vars_as_factors = TRUE,   with_mae_col_data = TRUE )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Experiment Specification — experimentSpecServer","text":"id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. mae_name (string) name MAE data used teal module. name_annotation (string NULL) annotation column use name return genes data. NULL, name column set empty strings. sample_vars_as_factors (flag) whether convert sample variables (columns colData() experiment) character factor variables. with_mae_col_data (flag) whether include colData() MAE experiment colData().","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Experiment Specification — experimentSpecServer","text":"List following reactive objects: data: hermes::AnyHermesData experiment. name: name experiment selected user. genes: data.frame genes data, columns id name. assays: names assays data.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/experimentSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Experiment Specification — experimentSpecServer","text":"","code":"ui <- function(id,                mae_name) {   ns <- NS(id)   teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = tags$div(       verbatimTextOutput(ns(\"summary\")),       verbatimTextOutput(ns(\"head\"))     )   ) }  server <- function(id,                    data,                    filter_panel_api,                    mae_name) {   moduleServer(id, function(input, output, session) {     output$encoding_ui <- renderUI({       tags$div(         experimentSpecInput(           session$ns(\"my_experiment\"),           data,           mae_name,           label_experiments = \"Please choose experiment\"         ),         selectInput(           session$ns(\"property\"),           \"Please choose property\",           c(\"data\", \"name\", \"genes\", \"assays\")         )       )     })     experiment <- experimentSpecServer(       \"my_experiment\",       data,       filter_panel_api,       mae_name     )     result <- reactive({       req(input$property)       switch(input$property,         data = experiment$data(),         name = experiment$name(),         genes = experiment$genes(),         assays = experiment$assays()       )     })     output$summary <- renderPrint({       result <- result()       hermes::summary(result)     })     output$head <- renderPrint({       result <- result()       utils::head(result)     })   }) }  my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"experimentSpec example\",         server = server,         server_args = list(mae_name = \"MAE\"),         ui = ui,         ui_args = list(mae_name = \"MAE\"),         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/function_arguments.html","id":null,"dir":"Reference","previous_headings":"","what":"Standard Function Arguments — function_arguments","title":"Standard Function Arguments — function_arguments","text":"documentation function lists conventional arguments functions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/function_arguments.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Standard Function Arguments — function_arguments","text":"adtte (data frame) adtte dataset. usubjid_var (string) variable name subject ID variable. mae (MultiAssayExperiment) contains AnyHermesData objects. object (AnyHermesData) contains RNA-seq values one experiment. genes (GeneSpec) specification gene(s) (signature), e.g. using hermes::gene_spec(). experiment_name (string) desired HermesData use. assay_name (string) assay define groups.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Gene Signature Specification — geneSpecInput","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"defines input gene signature specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"","code":"geneSpecInput(   inputId,   funs,   label_genes = \"Select Gene(s)\",   label_funs = \"Select Gene Summary\",   label_text_button = \"Enter list of genes\",   label_lock_button =     \"Lock gene selection (so that it does not get updated when filtering)\",   label_select_all_button = paste0(\"Select All Genes (first \", max_options, \")\"),   label_select_none_button = \"Select None\",   max_options = 200L,   max_selected = max_options )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"inputId (string) ID used call module input. funs (named list) names list used function selection drop menu. label_genes (string) label gene selection. label_funs (string) label function selection. label_text_button (string) label text input button. label_lock_button (string) label lock button. label_select_all_button (string) label selecting genes button. label_select_none_button (string) label selecting genes button. max_options (count) maximum number gene options rendering selected via \"Select \". max_selected (count) maximum number genes can selected.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecInput.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"","code":"geneSpecInput(\"my_genes\", list(mean = colMeans), label_funs = \"Please select function\") #> <div class=\"row\"> #>   <div class=\"col-sm-8\"> #>     <label class=\"control-label\">Select Gene(s)<\/label> #>   <\/div> #>   <div class=\"col-sm-2\"> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_genes-select_none_button\" title=\"Select None\" type=\"button\"> #>       <span> #>         <i aria-label=\"remove-circle icon\" class=\"glyphicon glyphicon-remove-circle\" role=\"presentation\"><\/i> #>       <\/span> #>     <\/button> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_genes-select_all_button\" title=\"Select All Genes (first 200)\" type=\"button\"> #>       <span> #>         <i aria-label=\"ok-circle icon\" class=\"glyphicon glyphicon-ok-circle\" role=\"presentation\"><\/i> #>       <\/span> #>     <\/button> #>   <\/div> #>   <div class=\"col-sm-2\"> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_genes-text_button\" title=\"Enter list of genes\" type=\"button\"> #>       <span> #>         <i class=\"fas fa-font\" role=\"presentation\" aria-label=\"font icon\"><\/i> #>       <\/span> #>     <\/button> #>     <div class=\"pull-right\" title=\"Lock gene selection (so that it does not get updated when filtering)\"> #>       <div class=\"form-group shiny-input-container\"> #>         <div class=\"pretty p-toggle p-plain p-icon p-pulse\"> #>           <input id=\"my_genes-lock_button\" type=\"checkbox\"/> #>           <div class=\"state p-on\"> #>             <i aria-label=\"lock icon\" class=\"fas fa-lock icon\" role=\"presentation\"><\/i> #>             <label> #>               <span><\/span> #>             <\/label> #>           <\/div> #>           <div class=\"state p-off\"> #>             <i aria-label=\"lock-open icon\" class=\"fas fa-lock-open icon\" role=\"presentation\"><\/i> #>             <label> #>               <span><\/span> #>             <\/label> #>           <\/div> #>         <\/div> #>       <\/div> #>     <\/div> #>   <\/div> #> <\/div> #> <div class=\"custom-select-input\"> #>   <div class=\"form-group shiny-input-container\"> #>     <label class=\"control-label shiny-label-null\" for=\"my_genes-genes\" id=\"my_genes-genes-label\"><\/label> #>     <div> #>       <select class=\"shiny-input-select form-control\" id=\"my_genes-genes\" multiple=\"multiple\"><option value=\"\"><\/option><\/select> #>       <script type=\"application/json\" data-for=\"my_genes-genes\" data-eval=\"[&quot;render&quot;]\">{\"placeholder\":\"- Nothing selected -\",\"render\":\"{\\n          option: function(item, escape) {\\n              return '<div> <span style=\\\"font-size: inherit;\\\">' + item.label + '<\\/div>' +\\n                ' <span style=\\\"color: #808080; font-size: xx-small;\\\" >' + item.value + '<\\/div> <\\/div>'\\n            }\\n          }\",\"searchField\":[\"value\",\"label\"],\"maxOptions\":200,\"maxItems\":200,\"plugins\":[\"selectize-plugin-a11y\"]}<\/script> #>     <\/div> #>   <\/div> #> <\/div> #> <div data-display-if=\"input.genes &amp;&amp; input.genes.length &gt; 1\" data-ns-prefix=\"my_genes-\"> #>   <div class=\"form-group shiny-input-container\"> #>     <label class=\"control-label\" id=\"my_genes-fun_name-label\" for=\"my_genes-fun_name\">Please select function<\/label> #>     <div> #>       <select id=\"my_genes-fun_name\" class=\"shiny-input-select\"><option value=\"mean\" selected>mean<\/option><\/select> #>       <script type=\"application/json\" data-for=\"my_genes-fun_name\" data-nonempty=\"\">{\"plugins\":[\"selectize-plugin-a11y\"]}<\/script> #>     <\/div> #>   <\/div> #> <\/div>"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Gene Signature Specification — geneSpecServer","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"defines server part gene signature specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"","code":"geneSpecServer(   id,   funs,   gene_choices,   label_modal_title = \"Enter list of genes\",   label_modal_footer = c(\"Please enter a comma-separated list of gene IDs and/or names.\",     \"(Note that genes not included in current choices will be removed)\") )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"id (string) shiny module id. funs (static named list) names list used function selection drop menu. gene_choices (reactive data.frame) returns possible gene choices populate UI, data.frame columns id name. label_modal_title (string) title dialog asks text input. label_modal_footer (character) lines text use footer dialog.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"Reactive hermes::GeneSpec can used input relevant hermes functions.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/geneSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"","code":"ui <- function(id, funs) {   ns <- NS(id)   teal.widgets::standard_layout(     encoding = tags$div(       geneSpecInput(         ns(\"my_genes\"),         funs = funs,         label_funs = \"Please select function\"       )     ),     output = textOutput(ns(\"result\"))   ) } server <- function(id,                    data,                    funs) {   checkmate::assert_class(data, \"reactive\")   checkmate::assert_class(shiny::isolate(data()), \"teal_data\")   moduleServer(id, function(input, output, session) {     gene_choices <- reactive({       mae <- data()[[\"MAE\"]]       object <- mae[[1]]       gene_ids <- rownames(object)       gene_names <- SummarizedExperiment::rowData(object)$symbol       gene_data <- data.frame(         id = gene_ids,         name = gene_names       )       gene_data[order(gene_data$name), ]     })     gene_spec <- geneSpecServer(       \"my_genes\",       funs = funs,       gene_choices = gene_choices     )     output$result <- renderText({       validate_gene_spec(         gene_spec(),         gene_choices()$id       )       gene_spec <- gene_spec()       gene_spec$get_label()     })   }) } funs <- list(mean = colMeans) my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"GeneSpec example\",         server = server,         server_args = list(funs = funs),         ui = ui,         ui_args = list(funs = funs),         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_assign_to_group_list.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function For Group List Creation — h_assign_to_group_list","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"helper function takes assignment list converts group list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_assign_to_group_list.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"","code":"h_assign_to_group_list(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_assign_to_group_list.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"x (named list character) input assignment list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_assign_to_group_list.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"combination list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_assign_to_group_list.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"","code":"assign_list <- list(   \"ASIAN\" = \"1\",   \"BLACK OR AFRICAN AMERICAN\" = \"1\",   \"MULTIPLE\" = \"2\",   \"UNKNOWN\" = \"2\",   \"WHITE\" = \"4\" ) objective_list <- list(   \"ASIAN/BLACK OR AFRICAN AMERICAN\" = c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\"),   \"MULTIPLE/UNKNOWN\" = c(\"MULTIPLE\", \"UNKNOWN\"),   \"WHITE\" = \"WHITE\" ) result_list <- h_assign_to_group_list(assign_list) stopifnot(identical(result_list, objective_list))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_collapse_levels.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"Given group list factor, helper function collapses levels factor accordingly also ensures resulting levels order given group list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_collapse_levels.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"","code":"h_collapse_levels(x, group_list)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_collapse_levels.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"x (factor) original factor. group_list (named list character) includes collapsing specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_collapse_levels.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"transformed factor x new levels.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_collapse_levels.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"","code":"set.seed(123) x <- factor(sample(   c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\", \"MULTIPLE\", \"UNKNOWN\", \"WHITE\"),   size = 30L,   replace = TRUE )) group_list <- list(   \"ASIAN/BLACK OR AFRICAN AMERICAN\" = c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\"),   \"MULTIPLE/UNKNOWN\" = c(\"MULTIPLE\", \"UNKNOWN\"),   \"WHITE\" = \"WHITE\" ) x_collapsed <- h_collapse_levels(x, group_list) stopifnot(identical(levels(x_collapsed), names(group_list)))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_extract_words.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Extract Words — h_extract_words","title":"Helper Function to Extract Words — h_extract_words","text":"helper function extracts words string. words defined containing lower upper case letters, colons dots. characters considered separators.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_extract_words.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Extract Words — h_extract_words","text":"","code":"h_extract_words(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_extract_words.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Extract Words — h_extract_words","text":"x (string) input.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_extract_words.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Extract Words — h_extract_words","text":"Character vector extracted words.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_extract_words.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Extract Words — h_extract_words","text":"","code":"h_extract_words(\"a, b, , c, 234; 34562 - GeneID:bla\") #> [1] \"a\"          \"b\"          \"c\"          \"234\"        \"34562\"      #> [6] \"GeneID:bla\" h_extract_words(\"GeneID:1820, sdf.393; 32596\") #> [1] \"GeneID:1820\" \"sdf.393\"     \"32596\""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_gene_data.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Format Gene Choices — h_gene_data","title":"Helper Function to Format Gene Choices — h_gene_data","text":"Given hermes::AnyHermesData data object, well annotation column name use gene name, function formats contained genes data.frame ready consumption h_order_genes() e.g.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_gene_data.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Format Gene Choices — h_gene_data","text":"","code":"h_gene_data(object, name_annotation)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_gene_data.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Format Gene Choices — h_gene_data","text":"object (AnyHermesData) contains RNA-seq values one experiment. name_annotation (string NULL) annotation column use name return genes data. NULL, name column set empty strings.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_gene_data.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Format Gene Choices — h_gene_data","text":"data.frame id name columns containing genes object.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_gene_data.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Helper Function to Format Gene Choices — h_gene_data","text":"Note missing names names contain whitespace replaced empty strings consistency better labeling UI downstream","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_gene_data.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Format Gene Choices — h_gene_data","text":"","code":"object <- hermes::hermes_data[1:10, ] h_gene_data(object, \"symbol\") #>                  id         name #> 1      GeneID:11185         INMT #> 2      GeneID:10677         AVIL #> 3  GeneID:101928428 LOC101928428 #> 4  GeneID:100422835      MIR3183 #> 5  GeneID:102466731     MIR6769A #> 6      GeneID:64881       PCDH20 #> 7     GeneID:286205         SCAI #> 8       GeneID:8365     HIST1H4H #> 9       GeneID:6804        STX1A #> 10 GeneID:100423018    MIR3156-3"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_km_mae_to_adtte.html","id":null,"dir":"Reference","previous_headings":"","what":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"function help merging MAE ADTTE.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_km_mae_to_adtte.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"","code":"h_km_mae_to_adtte(   adtte,   mae,   genes,   experiment_name = \"hd1\",   assay_name = \"counts\",   usubjid_var = \"USUBJID\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_km_mae_to_adtte.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"adtte (data frame) adtte dataset. mae (MultiAssayExperiment) contains AnyHermesData objects. genes (GeneSpec) specification gene(s) (signature), e.g. using hermes::gene_spec(). experiment_name (string) desired HermesData use. assay_name (string) assay define groups. usubjid_var (string) variable name subject ID variable.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_km_mae_to_adtte.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"data frame containing columns/rows adtte match subject ID row names MAE gene samples available given experiment. attribute gene_cols contains column names gene columns.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_km_mae_to_adtte.html","id":"note","dir":"Reference","previous_headings":"","what":"Note","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"final gene column names can start different string original gene IDs (labels), particular white space colons removed.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_km_mae_to_adtte.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"","code":"mae <- hermes::multi_assay_experiment adtte <- teal.modules.hermes::rADTTE %>%   dplyr::mutate(CNSR = as.logical(CNSR))  new_adtte <- h_km_mae_to_adtte(   adtte,   mae,   genes = hermes::gene_spec(\"GeneID:1820\"),   experiment_name = \"hd2\" ) new_adtte2 <- h_km_mae_to_adtte(   adtte,   mae,   genes = hermes::gene_spec(c(\"GeneID:1820\", \"GeneID:94115\"), fun = colMeans),   experiment_name = \"hd2\" ) new_adtte3 <- h_km_mae_to_adtte(   adtte,   mae,   genes = hermes::gene_spec(c(A = \"GeneID:1820\", B = \"GeneID:94115\")),   experiment_name = \"hd2\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_order_genes.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Order Gene Choices — h_order_genes","title":"Helper Function to Order Gene Choices — h_order_genes","text":"possible gene choices ordered follows. First come genes non-empty name, ordered name alphabetically. Last come genes empty name, ordered ID alphabetically.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_order_genes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Order Gene Choices — h_order_genes","text":"","code":"h_order_genes(genes)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_order_genes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Order Gene Choices — h_order_genes","text":"genes (data.frame) containing id name columns gene choices. Note missing values allowed.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_order_genes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Order Gene Choices — h_order_genes","text":"ordered data.frame.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_order_genes.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Order Gene Choices — h_order_genes","text":"","code":"genes <- data.frame(   id = c(\"7\", \"1\", \"2\", \"345346\", \"0\"),   name = c(\"e\", \"\", \"c\", \"\", \"a\") ) h_order_genes(genes) #>       id name #> 5      0    a #> 3      2    c #> 1      7    e #> 2      1      #> 4 345346"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_parse_genes.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Parse Genes — h_parse_genes","title":"Helper Function to Parse Genes — h_parse_genes","text":"helper function takes vector words tries match id name columns possible gene choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_parse_genes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Parse Genes — h_parse_genes","text":"","code":"h_parse_genes(words, choices)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_parse_genes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Parse Genes — h_parse_genes","text":"words (character) containing gene IDs names. choices (data.frame) containing id name columns new choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_parse_genes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Parse Genes — h_parse_genes","text":"subset choices matches words ID name.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_parse_genes.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Parse Genes — h_parse_genes","text":"","code":"h_parse_genes(   c(\"a\", \"2535\"),   data.frame(id = as.character(2533:2537), name = letters[1:5]) ) #>     id name #> 1 2533    a #> 3 2535    c"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_update_gene_selection.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Update Gene Selection — h_update_gene_selection","title":"Helper Function to Update Gene Selection — h_update_gene_selection","text":"helper function takes intersection selected choices genes updates inputId accordingly. shows notification selected genes available.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_update_gene_selection.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Update Gene Selection — h_update_gene_selection","text":"","code":"h_update_gene_selection(session, inputId, selected, choices)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/h_update_gene_selection.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Update Gene Selection — h_update_gene_selection","text":"session (ShinySession) session object. inputId (string) ID used call module input. selected (character) currently selected gene IDs. choices (data.frame) containing id name columns new choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/heatmap_plot.html","id":null,"dir":"Reference","previous_headings":"","what":"Correlation Heatmap Plot — heatmap_plot","title":"Correlation Heatmap Plot — heatmap_plot","text":"function plots correlation heatmap.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/heatmap_plot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Correlation Heatmap Plot — heatmap_plot","text":"","code":"heatmap_plot(object, assay_name)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/heatmap_plot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Correlation Heatmap Plot — heatmap_plot","text":"object (AnyHermesData) contains RNA-seq values one experiment. assay_name (string) assay define groups.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/heatmap_plot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Correlation Heatmap Plot — heatmap_plot","text":"Plot displayed teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/heatmap_plot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Correlation Heatmap Plot — heatmap_plot","text":"","code":"library(hermes) #> Loading required package: ggfortify #> Loading required package: SummarizedExperiment #> Loading required package: MatrixGenerics #> Loading required package: matrixStats #>  #> Attaching package: ‘MatrixGenerics’ #> The following objects are masked from ‘package:matrixStats’: #>  #>     colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse, #>     colCounts, colCummaxs, colCummins, colCumprods, colCumsums, #>     colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs, #>     colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats, #>     colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds, #>     colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads, #>     colWeightedMeans, colWeightedMedians, colWeightedSds, #>     colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet, #>     rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods, #>     rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps, #>     rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins, #>     rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks, #>     rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars, #>     rowWeightedMads, rowWeightedMeans, rowWeightedMedians, #>     rowWeightedSds, rowWeightedVars #> Loading required package: GenomicRanges #> Loading required package: stats4 #> Loading required package: BiocGenerics #>  #> Attaching package: ‘BiocGenerics’ #> The following objects are masked from ‘package:stats’: #>  #>     IQR, mad, sd, var, xtabs #> The following objects are masked from ‘package:base’: #>  #>     Filter, Find, Map, Position, Reduce, anyDuplicated, aperm, append, #>     as.data.frame, basename, cbind, colnames, dirname, do.call, #>     duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted, #>     lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin, #>     pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table, #>     tapply, union, unique, unsplit, which.max, which.min #> Loading required package: S4Vectors #>  #> Attaching package: ‘S4Vectors’ #> The following object is masked from ‘package:utils’: #>  #>     findMatches #> The following objects are masked from ‘package:base’: #>  #>     I, expand.grid, unname #> Loading required package: IRanges #> Loading required package: GenomeInfoDb #> Loading required package: Biobase #> Welcome to Bioconductor #>  #>     Vignettes contain introductory material; view with #>     'browseVignettes()'. To cite Bioconductor, see #>     'citation(\"Biobase\")', and for packages 'citation(\"pkgname\")'. #>  #> Attaching package: ‘Biobase’ #> The following object is masked from ‘package:MatrixGenerics’: #>  #>     rowMedians #> The following objects are masked from ‘package:matrixStats’: #>  #>     anyMissing, rowMedians #>  #> Attaching package: ‘hermes’ #> The following object is masked from ‘package:stats’: #>  #>     filter object <- HermesData(summarized_experiment) result <- heatmap_plot(object, assay_name = \"counts\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_css_files.html","id":null,"dir":"Reference","previous_headings":"","what":"Include CSS files from /inst/css/ package directory to application header — include_css_files","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"system.file used access files packages, work devtools. Therefore, redefine method package needed. Thus, export method","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_css_files.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"","code":"include_css_files(pattern = \"*\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_css_files.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"pattern (character) pattern files included","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_css_files.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"HTML code includes CSS files","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_js_files.html","id":null,"dir":"Reference","previous_headings":"","what":"Include JS files from /inst/js/ package directory to application header — include_js_files","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"system.file used access files packages, work devtools. Therefore, redefine method package needed. Thus, export method","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_js_files.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"","code":"include_js_files(pattern = \"*\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_js_files.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"pattern (character) pattern files included, passed system.file except (character) vector basename filenames excluded","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/include_js_files.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"HTML code includes JS files","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/is_blank.html","id":null,"dir":"Reference","previous_headings":"","what":"Checking for Empty String — is_blank","title":"Checking for Empty String — is_blank","text":"predicate function helpful functions arguments yet initialized teal module.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/is_blank.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Checking for Empty String — is_blank","text":"","code":"is_blank(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/is_blank.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Checking for Empty String — is_blank","text":"x object check.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/is_blank.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Checking for Empty String — is_blank","text":"Flag whether x identical empty string, .e. \"\".","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/is_blank.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Checking for Empty String — is_blank","text":"","code":"is_blank(\"\") #> [1] TRUE is_blank(\" \") #> [1] FALSE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/module_arguments.html","id":null,"dir":"Reference","previous_headings":"","what":"Standard Module Arguments — module_arguments","title":"Standard Module Arguments — module_arguments","text":"documentation function lists conventional arguments hermes teal modules.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/module_arguments.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Standard Module Arguments — module_arguments","text":"data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. label (string) menu item label module teal app. inputId (string) ID used call module input. adtte_name (string) name ADTTE dataset. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . reporter (Reporter) object pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). id (string) shiny module id. plot_height (list) list integers set default, minimum, maximum plot height. plot_width (list) list integers set default, minimum, maximum plot width. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. .test (flag) whether display internal structure plot testing purposes.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/multiSampleVarSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"multiple sample variables used given module, wrapper makes much easier specify server function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/multiSampleVarSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"","code":"multiSampleVarSpecServer(inputIds, original_data, ...)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/multiSampleVarSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"inputIds (character) multiple input IDs corresponding different sample variables specified UI function. original_data (reactive SummarizedExperiment) input experiment sample variables extracted via SummarizedExperiment::colData() eligible selection. ... additional arguments documented sampleVarSpecServer(), namely mandatory experiment_name optional categorical_only, num_levels label_modal_title. transformed_data assign_lists specified already specified internally .","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/multiSampleVarSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"List final transformed experiment_data reactive list vars contains selected sample variables reactives input ID.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/multiSampleVarSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"","code":"if (FALSE) { # In the server use: sample_var_specs <- multiSampleVarSpecServer(   inputIds = c(\"facet_var\", \"color_var\"),   experiment_name = reactive({     input$experiment_name   }),   original_data = ori_data # nolint Please update the <ori_data> ) # Then can extract the transformed data and selected variables later: experiment_data <- sample_var_specs$experiment_data() facet_var <- sample_var_specs$vars$facet_var() color_var <- sample_var_specs$vars$color_var() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/rADTTE.html","id":null,"dir":"Reference","previous_headings":"","what":"Random Time to Event Analysis Dataset — rADTTE","title":"Random Time to Event Analysis Dataset — rADTTE","text":"Random Time Event Analysis Dataset","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/rADTTE.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Random Time to Event Analysis Dataset — rADTTE","text":"","code":"rADTTE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/rADTTE.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Random Time to Event Analysis Dataset — rADTTE","text":"object class tbl_df (inherits tbl, data.frame) 2000 rows 67 columns.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/rADTTE.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Random Time to Event Analysis Dataset — rADTTE","text":"internal","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Sample Variable Specification — sampleVarSpecInput","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"defines input sample variable specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"","code":"sampleVarSpecInput(   inputId,   label_vars = \"Select sample variable\",   label_levels_button = \"Combine factor levels\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"inputId (string) ID used call module input. label_vars (string) label sample variable selection. label_levels_button (string) label levels combination button.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecInput.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"","code":"sampleVarSpecInput(\"my_vars\", label_vars = \"Select faceting variable\") #> <div class=\"row\"> #>   <div class=\"col-sm-8\"> #>     <label class=\"control-label\">Select faceting variable<\/label> #>   <\/div> #>   <div class=\"col-sm-4\"> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_vars-levels_button\" title=\"Combine factor levels\" type=\"button\"> #>       <span> #>         <i class=\"fas fa-table\" role=\"presentation\" aria-label=\"table icon\"><\/i> #>       <\/span> #>     <\/button> #>   <\/div> #> <\/div> #> <div class=\"custom-select-input\"> #>   <div> #>     <script> #>         $(function() { #>           $('#my_vars-sample_var').on('change', function(e) { #>             var select_concat = $(this).val().length ? $(this).val().join(', ') : 'NULL'; #>             $('#my_vars-sample_var_selected_text').html(select_concat); #>           }) #>         })<\/script> #>     <div> #>       <div id=\"my_vars-sample_var_input\" style=\"display: block;\"> #>         <div class=\"form-group shiny-input-container\"> #>           <label class=\"control-label shiny-label-null\" for=\"my_vars-sample_var\" id=\"my_vars-sample_var-label\"><\/label> #>           <select data-actions-box=\"false\" data-none-selected-text=\"- Nothing selected -\" data-max-options=\"1\" data-show-subtext=\"true\" data-live-search=\"false\" data-state-input=\"true\" id=\"my_vars-sample_var\" class=\"selectpicker form-control\" autocomplete=\"off\" multiple=\"multiple\"><option value=\"\"><\/option><\/select> #>         <\/div> #>       <\/div> #>       <div id=\"my_vars-sample_var_fixed\" style=\"display: none;\"> #>         <label class=\"control-label\"><\/label> #>         <code id=\"my_vars-sample_var_selected_text\">NULL<\/code> #>       <\/div> #>     <\/div> #>   <\/div> #> <\/div>"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Sample Variable Specification — sampleVarSpecServer","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"defines server part sample variable specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"","code":"sampleVarSpecServer(   id,   experiment_name,   original_data,   transformed_data = original_data,   assign_lists = reactiveValues(),   num_levels = NULL,   categorical_only = !is.null(num_levels),   explicit_na = FALSE,   label_modal_title = \"Please click to group the original factor levels\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"id (string) shiny module id. experiment_name (reactive string) name input experiment. original_data (reactive SummarizedExperiment) input experiment sample variables extracted via SummarizedExperiment::colData() eligible selection. transformed_data (reactive SummarizedExperiment) used multiple sample variables can selected app. case, pass pre-transformed data. assign_lists (reactivevalues) object share factor level groupings across multiple sample variables. num_levels (count NULL) required number levels combining original levels. NULL numbers levels allowed. categorical_only (flag) whether categorical variables selected . explicit_na (flag) whether colData original_data transformed hermes::h_df_factors_with_explicit_na processing. means also NA made explicit factor level counted num_levels. label_modal_title (string) title dialog asks text input.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"Reactive SummarizedExperiment::SummarizedExperiment can used input relevant hermes functions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecServer.html","id":"note","dir":"Reference","previous_headings":"","what":"Note","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"atomic columns (e.g. DataFrame columns) colData completely missing (NA) shown selection. num_levels specified factor columns available.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/sampleVarSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"","code":"ui <- function(id) {   checkmate::assert_class(data, \"teal_data\")   ns <- NS(id)    teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = plotOutput(ns(\"plot\"))   ) } server <- function(id,                    data) {   checkmate::assert_class(data, \"reactive\")   checkmate::assert_class(shiny::isolate(data()), \"teal_data\")   moduleServer(id, function(input, output, session) {     output$encoding_ui <- renderUI({       mae <- data()[[\"MAE\"]]       experiment_name_choices <- names(mae)       tags$div(         selectInput(session$ns(\"experiment_name\"), \"Select experiment\", experiment_name_choices),         sampleVarSpecInput(session$ns(\"facet_var\"), \"Select faceting variable\")       )     })     experiment_data <- reactive({       req(input$experiment_name)       mae <- data()[[\"MAE\"]]       object <- mae[[input$experiment_name]]       SummarizedExperiment::colData(object) <-         hermes::df_cols_to_factor(SummarizedExperiment::colData(object))       object     })     facet_var_spec <- sampleVarSpecServer(       \"facet_var\",       experiment_name = reactive({         input$experiment_name       }),       original_data = experiment_data     )     output$plot <- renderPlot({       experiment_data_final <- facet_var_spec$experiment_data()       facet_var <- facet_var_spec$sample_var()       hermes::draw_boxplot(         experiment_data_final,         assay_name = \"counts\",         genes = hermes::gene_spec(hermes::genes(experiment_data_final)[1]),         facet_var = facet_var       )     })   }) } my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"sampleVarSpec example\",         server = server,         ui = ui,         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/teal.modules.hermes-package.html","id":null,"dir":"Reference","previous_headings":"","what":"teal.modules.hermes Package — teal.modules.hermes-package","title":"teal.modules.hermes Package — teal.modules.hermes-package","text":"teal.modules.hermes provides RNA-seq analysis modules add teal application.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/teal.modules.hermes-package.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"teal.modules.hermes Package — teal.modules.hermes-package","text":"Maintainer: Daniel Sabanés Bové daniel.sabanes_bove@roche.com Authors: Nikolas Burkoff Dinakar Kulkarni Konrad Pagacz Namrata Bhatia Dawid Kaledkowski Pawel Rucki Jeff Luong Stefanie Bienert Haocheng Li Lyndsee Midori Zhang contributors: Sorin Voicu [contributor] Benoit Falquet [contributor] Mahmoud Hallal [contributor] Tim Treis [contributor] Vedha Viyash [contributor] F. Hoffmann-La Roche AG [copyright holder, funder]","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_barplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Barplot — tm_g_barplot","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"module provides interactive barplot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_barplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"","code":"tm_g_barplot(   label,   mae_name,   exclude_assays = character(),   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_barplot(   id,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_barplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   summary_funs,   .test = FALSE )  sample_tm_g_barplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_barplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_barplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_barplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"ui_g_barplot(): sets user interface. srv_g_barplot(): sets server reactive graph. sample_tm_g_barplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_barplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_barplot(       label = \"barplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_barplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_barplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_boxplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"module provides interactive boxplot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_boxplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"","code":"tm_g_boxplot(   label,   mae_name,   exclude_assays = character(),   summary_funs = list(None = NULL, Mean = colMeans, Median = matrixStats::colMedians, Max     = matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_boxplot(   id,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_boxplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   summary_funs,   .test = FALSE )  sample_tm_g_boxplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_boxplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_boxplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_boxplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"ui_g_boxplot(): sets user interface. srv_g_boxplot(): sets server reactive graph. sample_tm_g_boxplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_boxplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_boxplot(       label = \"boxplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_boxplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_boxplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_forest_tte.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for Survival Forest Plot — tm_g_forest_tte","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"module provides interactive survival forest plot.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_forest_tte.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"","code":"tm_g_forest_tte(   label,   adtte_name,   mae_name,   adtte_vars = list(aval = \"AVAL\", is_event = \"is_event\", paramcd = \"PARAMCD\", usubjid =     \"USUBJID\", avalu = \"AVALU\"),   exclude_assays = \"counts\",   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   plot_height = c(600L, 200L, 2000L),   plot_width = c(1360L, 500L, 2000L),   .test = FALSE )  ui_g_forest_tte(   id,   adtte_name,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_forest_tte(   id,   data,   filter_panel_api,   reporter,   adtte_name,   mae_name,   adtte_vars,   exclude_assays,   summary_funs,   plot_height,   plot_width,   .test = FALSE )  sample_tm_g_forest_tte(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_forest_tte.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"label (string) menu item label module teal app. adtte_name (string) name ADTTE dataset. mae_name (string) name MAE data used teal module. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). plot_height (list) list integers set default, minimum, maximum plot height. plot_width (list) list integers set default, minimum, maximum plot width. .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_forest_tte.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_forest_tte.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"ui_g_forest_tte(): sets user interface. srv_g_forest_tte(): sets server reactive graph. sample_tm_g_forest_tte(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_forest_tte.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"","code":"data <- teal_data() data <- within(data, {   ADTTE <- teal.modules.hermes::rADTTE %>%     dplyr::mutate(is_event = .data$CNSR == 0)   MAE <- hermes::multi_assay_experiment }) datanames <- c(\"ADTTE\", \"MAE\") datanames(data) <- datanames join_keys(data)[\"ADTTE\", \"ADTTE\"] <- c(\"STUDYID\", \"USUBJID\", \"PARAMCD\")  app <- init(   data = data,   modules = modules(     tm_g_forest_tte(       label = \"forestplot\",       adtte_name = \"ADTTE\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_forest_tte if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_forest_tte() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_km.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for Kaplan-Meier Plot — tm_g_km","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"teal module produces grid style Kaplan-Meier plot data ADaM structure.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_km.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"","code":"tm_g_km(   label,   adtte_name,   mae_name,   adtte_vars = list(aval = \"AVAL\", is_event = \"is_event\", paramcd = \"PARAMCD\", usubjid =     \"USUBJID\", avalu = \"AVALU\"),   exclude_assays = \"counts\",   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_km(   id,   adtte_name,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_km(   id,   data,   filter_panel_api,   reporter,   adtte_name,   mae_name,   adtte_vars,   summary_funs,   exclude_assays,   .test = FALSE )  sample_tm_g_km(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_km.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"label (string) menu item label module teal app. adtte_name (string) name ADTTE dataset. mae_name (string) name MAE data used teal module. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_km.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_km.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"ui_g_km(): sets user interface. srv_g_km(): sets user interface. sample_tm_g_km(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_km.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"","code":"data <- teal_data() data <- within(data, {   ADTTE <- teal.modules.hermes::rADTTE %>%     dplyr::mutate(is_event = .data$CNSR == 0)   MAE <- hermes::multi_assay_experiment }) datanames <- c(\"ADTTE\", \"MAE\") datanames(data) <- datanames join_keys(data)[\"ADTTE\", \"ADTTE\"] <- c(\"STUDYID\", \"USUBJID\", \"PARAMCD\")   modules <- modules(   tm_g_km(     label = \"kaplan-meier\",     adtte_name = \"ADTTE\",     mae_name = \"MAE\"   ) ) #> Initializing tm_g_km  app <- init(   data = data,   modules = modules )  if (interactive()) {   shinyApp(ui = app$ui, server = app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_km() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_pca.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for PCA Analysis — tm_g_pca","title":"Teal Module for PCA Analysis — tm_g_pca","text":"module provides interactive principal components plot interactive heatmap correlation principal components sample variables.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_pca.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for PCA Analysis — tm_g_pca","text":"","code":"tm_g_pca(   label,   mae_name,   exclude_assays = character(),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_pca(id, mae_name, pre_output, post_output, .test = FALSE)  srv_g_pca(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   .test = FALSE )  sample_tm_g_pca(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_pca.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for PCA Analysis — tm_g_pca","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_pca.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for PCA Analysis — tm_g_pca","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_pca.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for PCA Analysis — tm_g_pca","text":"ui_g_pca(): sets user interface. srv_g_pca(): sets server reactive graph. sample_tm_g_pca(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_pca.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for PCA Analysis — tm_g_pca","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_pca(       label = \"PCA plot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_pca if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_pca() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_quality.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Quality Control — tm_g_quality","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"module adds quality flags, filters genes /samples, normalizes AnyHermesData objects provides interactive plots RNA-seq gene expression quality control.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_quality.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"","code":"tm_g_quality(   label,   mae_name,   exclude_assays = character(),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_quality(id, mae_name, pre_output, post_output, .test = FALSE)  srv_g_quality(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   .test = FALSE )  sample_tm_g_quality(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_quality.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_quality.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_quality.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"ui_g_quality(): sets user interface. srv_g_quality(): sets server reactive graphs. sample_tm_g_quality(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_quality.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_quality(       label = \"Quality Control\",       mae_name = \"MAE\"     )   ) ) if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_quality() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_scatterplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"module provides interactive scatterplot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_scatterplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"","code":"tm_g_scatterplot(   label,   mae_name,   exclude_assays = \"counts\",   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_scatterplot(   id,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_scatterplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   summary_funs,   .test = FALSE )  sample_tm_g_scatterplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_scatterplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_scatterplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_scatterplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"ui_g_scatterplot(): sets user interface. srv_g_scatterplot(): sets server reactive graph. sample_tm_g_scatterplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_scatterplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_scatterplot(       label = \"scatterplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_scatterplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_scatterplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_volcanoplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"module provides interactive volcano plot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_volcanoplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"","code":"tm_g_volcanoplot(   label,   mae_name,   exclude_assays = character(),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_volcanoplot(id, mae_name, pre_output, post_output, .test = FALSE)  srv_g_volcanoplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   .test = FALSE )  sample_tm_g_volcanoplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_volcanoplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_volcanoplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_volcanoplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"ui_g_volcanoplot(): sets user interface. srv_g_volcanoplot(): sets server reactive graph. sample_tm_g_volcanoplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/tm_g_volcanoplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_volcanoplot(       label = \"volcanoplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_volcanoplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_volcanoplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/top_gene_plot.html","id":null,"dir":"Reference","previous_headings":"","what":"Most Expressed Genes Plot — top_gene_plot","title":"Most Expressed Genes Plot — top_gene_plot","text":"function plots expressed genes.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/top_gene_plot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Most Expressed Genes Plot — top_gene_plot","text":"","code":"top_gene_plot(object, assay_name)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/top_gene_plot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Most Expressed Genes Plot — top_gene_plot","text":"object (AnyHermesData) contains RNA-seq values one experiment. assay_name (string) assay define groups.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/top_gene_plot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Most Expressed Genes Plot — top_gene_plot","text":"Plot displayed teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/top_gene_plot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Most Expressed Genes Plot — top_gene_plot","text":"","code":"library(hermes) object <- HermesData(summarized_experiment) result <- top_gene_plot(object, assay_name = \"counts\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/validate_gene_spec.html","id":null,"dir":"Reference","previous_headings":"","what":"Validation of Gene Specification — validate_gene_spec","title":"Validation of Gene Specification — validate_gene_spec","text":"validation function checks given hermes::GeneSpec least one gene selected genes included possible choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/validate_gene_spec.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Validation of Gene Specification — validate_gene_spec","text":"","code":"validate_gene_spec(gene_spec, gene_choices)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/validate_gene_spec.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Validation of Gene Specification — validate_gene_spec","text":"gene_spec (GeneSpec) gene specification. gene_choices (character) possible gene choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/validate_n_levels.html","id":null,"dir":"Reference","previous_headings":"","what":"Validation of Number of Levels — validate_n_levels","title":"Validation of Number of Levels — validate_n_levels","text":"validation function checks given vector x factor specified number levels.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/validate_n_levels.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Validation of Number of Levels — validate_n_levels","text":"","code":"validate_n_levels(x, name, n_levels)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/reference/validate_n_levels.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Validation of Number of Levels — validate_n_levels","text":"x (factor) factor validate. name (string) name x app. n_levels (count) required number factor levels x.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"miscellaneous-0-1-6-9009","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.6.9009","text":"Added placeholders assaySpec, adtteSpec geneSpec inputs option selected. Disabled select input assaySpec adtteSpec options available. module developers: module gets teal_data object UI reactive(<teal_data>) server","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"enhancements-0-1-6-9009","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"teal.modules.hermes 0.1.6.9009","text":"Updated documentation vignettes new way specifying data teal::init(). data argument accepts teal_data object.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"bug-fixes-0-1-5","dir":"Changelog","previous_headings":"","what":"Bug Fixes","title":"teal.modules.hermes 0.1.5","text":"Filtering data filter panel now correctly triggers sampleVarSpecModule.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"breaking-changes-0-1-5","dir":"Changelog","previous_headings":"","what":"Breaking changes","title":"teal.modules.hermes 0.1.5","text":"Replaced datasets argument containing FilteredData new arguments data (tdata object) filter_panel_api (FilterPanelAPI).","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"miscellaneous-0-1-5","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.5","text":"Removed scda dependencies. Migrate shinytest2.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"tealmoduleshermes-014","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.4","title":"teal.modules.hermes 0.1.4","text":"Added teal.reporter functionality modules. Add installation instruction","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"tealmoduleshermes-013","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.3","title":"teal.modules.hermes 0.1.3","text":"Improve selection sample variables forest module (tm_g_forest_tte) categorical variables can selected first place.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"miscellaneous-0-1-3","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.3","text":"Added template pkgdown site. Updated package authors. Added option categorical_only sampleVarSpec server module, allows show categorical sample variables selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"tealmoduleshermes-012","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.2","title":"teal.modules.hermes 0.1.2","text":"Rewrote modules use moduleServer updated call plot_with_settings_srv changes teal.devel. Replaced calls teal::root_modules teal::modules following deprecation teal::root_modules. Added basic logging modules. Fixed geneSpecInput hermes app doesn’t fail anymore (chrome) experiment genes.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"bug-fixes-0-1-1","dir":"Changelog","previous_headings":"","what":"Bug Fixes","title":"teal.modules.hermes 0.1.1","text":"Updated legend PCA plot. Gene selection thousand genes longer hangs application. achieved different selection input corresponding geneSpec shiny module. atomic columns colData least one value can now selected sampleVarSpecModule.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"miscellaneous-0-1-1","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.1","text":"Updated R version requirement >= 3.6. Updated sampleVarSpec geneSpec modules new icons remove warnings using shiny version >= 1.7. Removed dependencies deprecated packages utils.nest test.nest.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"tealmoduleshermes-010","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.0","title":"teal.modules.hermes 0.1.0","text":"First release teal.modules.hermes package, contains teal modules RNA-seq analysis using hermes package. New users first begin reading README.md teal.modules.hermes package become familiar.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/main/news/index.html","id":"new-features-0-1-0","dir":"Changelog","previous_headings":"","what":"New Features","title":"teal.modules.hermes 0.1.0","text":"tm_g_barplot barplot module RNA-seq gene expression analysis. tm_g_boxplot boxplot module RNA-seq gene expression analysis. tm_g_forest_tte survival forest plot module analyze RNA-seq gene expression data together survival data. tm_g_km Kaplan-Meier plot module analyze RNA-seq gene expression data together survival data. tm_g_pca principal components analysis plot module RNA-seq gene expression analysis. tm_g_quality quality control module RNA-seq gene expression data. tm_g_scatterplot scatterplot module RNA-seq gene expression analysis. tm_g_volcanoplot differential gene expression analysis module.","code":""}]
+[{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"our-pledge","dir":"","previous_headings":"","what":"Our Pledge","title":"Contributor Covenant Code of Conduct","text":"members, contributors, leaders pledge make participation community harassment-free experience everyone, regardless age, body size, visible invisible disability, ethnicity, sex characteristics, gender identity expression, level experience, education, socio-economic status, nationality, personal appearance, race, caste, color, religion, sexual identity orientation. pledge act interact ways contribute open, welcoming, diverse, inclusive, healthy community.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"our-standards","dir":"","previous_headings":"","what":"Our Standards","title":"Contributor Covenant Code of Conduct","text":"Examples behavior contributes positive environment community include: Demonstrating empathy kindness toward people respectful differing opinions, viewpoints, experiences Giving gracefully accepting constructive feedback Accepting responsibility apologizing affected mistakes, learning experience Focusing best just us individuals, overall community Examples unacceptable behavior include: use sexualized language imagery, sexual attention advances kind Trolling, insulting derogatory comments, personal political attacks Public private harassment Publishing others’ private information, physical email address, without explicit permission conduct reasonably considered inappropriate professional setting","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"enforcement-responsibilities","dir":"","previous_headings":"","what":"Enforcement Responsibilities","title":"Contributor Covenant Code of Conduct","text":"Community leaders responsible clarifying enforcing standards acceptable behavior take appropriate fair corrective action response behavior deem inappropriate, threatening, offensive, harmful. Community leaders right responsibility remove, edit, reject comments, commits, code, wiki edits, issues, contributions aligned Code Conduct, communicate reasons moderation decisions appropriate.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"Contributor Covenant Code of Conduct","text":"Code Conduct applies within community spaces, also applies individual officially representing community public spaces. Examples representing community include using official e-mail address, posting via official social media account, acting appointed representative online offline event.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"enforcement","dir":"","previous_headings":"","what":"Enforcement","title":"Contributor Covenant Code of Conduct","text":"Instances abusive, harassing, otherwise unacceptable behavior may reported community leaders responsible enforcement [INSERT CONTACT METHOD]. complaints reviewed investigated promptly fairly. community leaders obligated respect privacy security reporter incident.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"enforcement-guidelines","dir":"","previous_headings":"","what":"Enforcement Guidelines","title":"Contributor Covenant Code of Conduct","text":"Community leaders follow Community Impact Guidelines determining consequences action deem violation Code Conduct:","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"id_1-correction","dir":"","previous_headings":"Enforcement Guidelines","what":"1. Correction","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Use inappropriate language behavior deemed unprofessional unwelcome community. Consequence: private, written warning community leaders, providing clarity around nature violation explanation behavior inappropriate. public apology may requested.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"id_2-warning","dir":"","previous_headings":"Enforcement Guidelines","what":"2. Warning","title":"Contributor Covenant Code of Conduct","text":"Community Impact: violation single incident series actions. Consequence: warning consequences continued behavior. interaction people involved, including unsolicited interaction enforcing Code Conduct, specified period time. includes avoiding interactions community spaces well external channels like social media. Violating terms may lead temporary permanent ban.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"id_3-temporary-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"3. Temporary Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: serious violation community standards, including sustained inappropriate behavior. Consequence: temporary ban sort interaction public communication community specified period time. public private interaction people involved, including unsolicited interaction enforcing Code Conduct, allowed period. Violating terms may lead permanent ban.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"id_4-permanent-ban","dir":"","previous_headings":"Enforcement Guidelines","what":"4. Permanent Ban","title":"Contributor Covenant Code of Conduct","text":"Community Impact: Demonstrating pattern violation community standards, including sustained inappropriate behavior, harassment individual, aggression toward disparagement classes individuals. Consequence: permanent ban sort public interaction within community.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CODE_OF_CONDUCT.html","id":"attribution","dir":"","previous_headings":"","what":"Attribution","title":"Contributor Covenant Code of Conduct","text":"Code Conduct adapted Contributor Covenant, version 2.1, available https://www.contributor-covenant.org/version/2/1/code_of_conduct.html. Community Impact Guidelines inspired Mozilla’s code conduct enforcement ladder. answers common questions code conduct, see FAQ https://www.contributor-covenant.org/faq. Translations available https://www.contributor-covenant.org/translations.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":null,"dir":"","previous_headings":"","what":"Contribution Guidelines","title":"Contribution Guidelines","text":"🙏 Thank taking time contribute! input deeply valued, whether issue, pull request, even feedback, regardless size, content scope.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"table-of-contents","dir":"","previous_headings":"","what":"Table of contents","title":"Contribution Guidelines","text":"👶 Getting started 📔 Code Conduct 🗃 License 📜 Issues 🚩 Pull requests 💻 Coding guidelines 🏆 Recognition model ❓ Questions","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"getting-started","dir":"","previous_headings":"","what":"Getting started","title":"Contribution Guidelines","text":"Please refer project documentation brief introduction. Please also see articles within project documentation additional information.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"code-of-conduct","dir":"","previous_headings":"","what":"Code of Conduct","title":"Contribution Guidelines","text":"Code Conduct governs project. Participants contributors expected follow rules outlined therein.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"license","dir":"","previous_headings":"","what":"License","title":"Contribution Guidelines","text":"contributions covered project’s license.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"issues","dir":"","previous_headings":"","what":"Issues","title":"Contribution Guidelines","text":"use GitHub track issues, feature requests, bugs. submitting new issue, please check issue already reported. issue already exists, please upvote existing issue 👍. new feature requests, please elaborate context benefit feature users, developers, relevant personas.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"github-flow","dir":"","previous_headings":"Pull requests","what":"GitHub Flow","title":"Contribution Guidelines","text":"repository uses GitHub Flow model collaboration. submit pull request: Create branch Please see branch naming convention . don’t write access repository, please fork . Make changes Make sure code passes checks imposed GitHub Actions well documented well tested unit tests sufficiently covering changes introduced Create pull request (PR) pull request description, please link relevant issue (), provide detailed description change, include assumptions. Address review comments, Post approval Merge PR write access. Otherwise, reviewer merge PR behalf. Pat back Congratulations! 🎉 now official contributor project! grateful contribution.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"branch-naming-convention","dir":"","previous_headings":"Pull requests","what":"Branch naming convention","title":"Contribution Guidelines","text":"Suppose changes related current issue current project; please name branch follows: <issue_id>_<short_description>. Please use underscore (_) delimiter word separation. example, 420_fix_ui_bug suitable branch name change resolving UI-related bug reported issue number 420 current project. change affects multiple repositories, please name branches follows: <issue_id>_<issue_repo>_<short description>. example, 69_awesomeproject_fix_spelling_error reference issue 69 reported project awesomeproject aims resolve one spelling errors multiple (likely related) repositories.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"monorepo-and-stageddependencies","dir":"","previous_headings":"Pull requests","what":"monorepo and staged.dependencies","title":"Contribution Guidelines","text":"Sometimes might need change upstream dependent package(s) able submit meaningful change. using staged.dependencies functionality simulate monorepo behavior. dependency configuration already specified project’s staged_dependencies.yaml file. need name feature branches appropriately. exception branch naming convention described . Please refer staged.dependencies package documentation details.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"coding-guidelines","dir":"","previous_headings":"","what":"Coding guidelines","title":"Contribution Guidelines","text":"repository follows unified processes standards adopted maintainers ensure software development carried consistently within teams cohesively across repositories.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"style-guide","dir":"","previous_headings":"Coding guidelines","what":"Style guide","title":"Contribution Guidelines","text":"repository follows standard tidyverse style guide uses lintr lint checks. Customized lint configurations available repository’s .lintr file.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"dependency-management","dir":"","previous_headings":"Coding guidelines","what":"Dependency management","title":"Contribution Guidelines","text":"Lightweight right weight. repository follows tinyverse recommedations limiting dependencies minimum.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"dependency-version-management","dir":"","previous_headings":"Coding guidelines","what":"Dependency version management","title":"Contribution Guidelines","text":"code compatible (!) historical versions given dependenct package, required specify minimal version DESCRIPTION file. particular: development version requires (imports) development version another package - required put abc (>= 1.2.3.9000).","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"r--package-versions","dir":"","previous_headings":"Coding guidelines > Recommended development environment & tools","what":"R & package versions","title":"Contribution Guidelines","text":"continuously test packages newest R version along recent dependencies CRAN BioConductor. recommend working environment also set way. can find details R version packages used R CMD check GitHub Action execution log - step prints R sessionInfo(). discover bugs older R versions older set dependencies, please create relevant bug reports.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"pre-commit","dir":"","previous_headings":"Coding guidelines > Recommended development environment & tools","what":"pre-commit","title":"Contribution Guidelines","text":"highly recommend use pre-commit tool combined R hooks pre-commit execute checks committing pushing changes. Pre-commit hooks already available repository’s .pre-commit-config.yaml file.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"recognition-model","dir":"","previous_headings":"","what":"Recognition model","title":"Contribution Guidelines","text":"mentioned previously, contributions deeply valued appreciated. contribution data available part repository insights, recognize significant contribution hence add contributor package authors list, following rules enforced: Minimum 5% lines code authored* (determined git blame query) top 5 contributors terms number commits lines added lines removed* *Excluding auto-generated code, including limited roxygen comments renv.lock files. package maintainer also reserves right adjust criteria recognize contributions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/CONTRIBUTING.html","id":"questions","dir":"","previous_headings":"","what":"Questions","title":"Contribution Guidelines","text":"questions regarding contribution guidelines, please contact package/repository maintainer.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/SECURITY.html","id":"reporting-security-issues","dir":"","previous_headings":"","what":"Reporting Security Issues","title":"Security Policy","text":"believe found security vulnerability repositories organization, please report us coordinated disclosure. Please report security vulnerabilities public GitHub issues, discussions, pull requests. Instead, please send email vulnerability.management[@]roche.com. Please include much information listed can help us better understand resolve issue: type issue (e.g., buffer overflow, SQL injection, cross-site scripting) Full paths source file(s) related manifestation issue location affected source code (tag/branch/commit direct URL) special configuration required reproduce issue Step--step instructions reproduce issue Proof--concept exploit code (possible) Impact issue, including attacker might exploit issue information help us triage report quickly.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/SECURITY.html","id":"data-security-standards-dss","dir":"","previous_headings":"","what":"Data Security Standards (DSS)","title":"Security Policy","text":"Please make sure reporting issues form bug, feature, pull request, sensitive information PII, PHI, PCI completely removed text attachments, including pictures videos.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/articles/Getting_Started.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Getting Started","text":"teal.modules.hermes package implementing number teal modules exploration RNA-sequencing counts data. addition predefined modules, teal.modules.hermes enables quick easy ad-hoc module creation.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/articles/Getting_Started.html","id":"ad-hoc-module-example","dir":"Articles","previous_headings":"","what":"Ad-hoc module example","title":"Getting Started","text":"Let’s assume function awesome_plot() takes count matrix makes awesome plot . Now like make Shiny app can filter patients, samples, select experiment MultiAssayExperiment (MAE), select count matrix experiment, etc. Nothing easier teal.modules.hermes! show quickly spin UI, server put together nice little app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/articles/Getting_Started.html","id":"ui-function","dir":"Articles","previous_headings":"Ad-hoc module example","what":"UI function","title":"Getting Started","text":"teal.modules.hermes provide modules make experiment assay selection super easy, see UI part:","code":"ui <- function(id, mae_name) {   ns <- NS(id)    teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = plotOutput(ns(\"awesome_plot\"))   ) }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/articles/Getting_Started.html","id":"server-function","dir":"Articles","previous_headings":"Ad-hoc module example","what":"Server function","title":"Getting Started","text":"Similarly server use modules, call awesome plotting function.","code":"srv <- function(input,                 output,                 session,                 data,                 filter_panel_api,                 mae_name) {   output$encoding_ui <- renderUI({     tags$div(       experimentSpecInput(session$ns(\"experiment\"), data, mae_name),       assaySpecInput(session$ns(\"assay\"))     )   })   experiment <- experimentSpecServer(     \"experiment\",     data = data,     filter_panel_api = filter_panel_api,     mae_name = mae_name,     name_annotation = NULL # If you have a gene name column in your rowData, can specify here.   )   assay <- assaySpecServer(\"assay\", experiment$assays)   output$awesome_plot <- renderPlot({     data <- experiment$data()     assay <- assay()     req(assay %in% SummarizedExperiment::assayNames(data))     counts <- SummarizedExperiment::assay(data, assay)     df <- data.frame(gene = rownames(counts), counts = rowSums(counts))     df <- na.omit(df[order(df$counts, decreasing = TRUE), ])     df$gene <- factor(df$gene, levels = df$gene)     df <- df[1:10, ]     ggplot(df, aes(x = gene, y = counts)) +       geom_col() +       theme(axis.text.x = element_text(angle = 90))   }) }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/articles/Getting_Started.html","id":"app-function","dir":"Articles","previous_headings":"Ad-hoc module example","what":"App function","title":"Getting Started","text":"Now let’s assume want spin app MAE.","code":"awesome_app <- function(mae, label = \"My awesome app\") {   mae_name <- \"MAE\"   data <- teal_data(MAE = hermes::lapply(mae, hermes::HermesData))   app <- init(     data = data,     modules = teal::modules(       module(         label = label,         server = srv,         server_args = list(mae_name = mae_name),         ui = ui,         ui_args = list(mae_name = mae_name),         datanames = mae_name       )     )   )   shinyApp(app$ui, app$server) }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/articles/Getting_Started.html","id":"testing-it","dir":"Articles","previous_headings":"Ad-hoc module example","what":"Testing it","title":"Getting Started","text":"test :","code":"awesome_app(hermes::multi_assay_experiment)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Daniel Sabanés Bové. Author, maintainer. Nikolas Burkoff. Author. Dinakar Kulkarni. Author. Konrad Pagacz. Author. Namrata Bhatia. Author. Dawid Kaledkowski. Author. Pawel Rucki. Author. Jeff Luong. Author. Stefanie Bienert. Author. Haocheng Li. Author. Lyndsee Midori Zhang. Author. Sorin Voicu. Contributor. Benoit Falquet. Contributor. Mahmoud Hallal. Contributor. Tim Treis. Contributor. Vedha Viyash. Contributor. F. Hoffmann-La Roche AG. Copyright holder, funder.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Sabanés Bové D, Burkoff N, Kulkarni D, Pagacz K, Bhatia N, Kaledkowski D, Rucki P, Luong J, Bienert S, Li H, Zhang L (2024). teal.modules.hermes: RNA-Seq Analysis Modules Add Teal Application. R package version 0.1.6.9010,  https://github.com/insightsengineering/teal.modules.hermes/, https://insightsengineering.github.io/teal.modules.hermes/.","code":"@Manual{,   title = {teal.modules.hermes: RNA-Seq Analysis Modules to Add to a Teal Application},   author = {Daniel {Sabanés Bové} and Nikolas Burkoff and Dinakar Kulkarni and Konrad Pagacz and Namrata Bhatia and Dawid Kaledkowski and Pawel Rucki and Jeff Luong and Stefanie Bienert and Haocheng Li and Lyndsee Midori Zhang},   year = {2024},   note = {R package version 0.1.6.9010,  https://github.com/insightsengineering/teal.modules.hermes/},   url = {https://insightsengineering.github.io/teal.modules.hermes/}, }"},{"path":[]},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/index.html","id":"what-is-teal","dir":"","previous_headings":"What is what","what":"What is teal?","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"teal shiny-based interactive exploration framework analyzing clinical trials data. teal currently provides dynamic filtering facility diverse data viewers. teal shiny applications built using standard shiny modules. See teal page details.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/index.html","id":"what-is-hermes","dir":"","previous_headings":"What is what","what":"What is hermes?","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"hermes facilitates preprocessing, analyzing, reporting RNA-seq data. core functionality built BioConductor ecosystem, especially SummarizedExperiment class HermesData class inherits. See vignette details.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/index.html","id":"so-what-is-then-tealmoduleshermes","dir":"","previous_headings":"What is what","what":"So what is then teal.modules.hermes?","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"teal.modules.hermes provides teal modules (can used part teal app), interactive RNA-seq data analysis using hermes. heavily built BioConductor classes, particular MultiAssayExperiment (MAE) expected contain HermesData experiments.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"RNA-Seq Analysis Modules to Add to a Teal Application","text":"July 2023 insightsengineering packages available r-universe. See package vignettes browseVignettes(package = \"teal.modules.hermes\") usage package.","code":"# stable versions install.packages('teal.modules.hermes', repos = c('https://insightsengineering.r-universe.dev', 'https://cloud.r-project.org'))  # beta versions install.packages('teal.modules.hermes', repos = c('https://pharmaverse.r-universe.dev', 'https://cloud.r-project.org'))"},{"path":[]},{"path":[]},{"path":[]},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/pull_request_template.html","id":null,"dir":"","previous_headings":"","what":"Pull Request","title":"Pull Request","text":"Fixes #nnn","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for ADTTE Specification — adtteSpecInput","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"defines input ADTTE specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"","code":"adtteSpecInput(inputId, label_paramcd = \"Select Endpoint\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"inputId (string) ID used call module input. label_paramcd (string) label endpoint (PARAMCD) selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for ADTTE Specification — adtteSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for ADTTE Specification — adtteSpecServer","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"defines server part ADTTE specification. resulting data set binned_adtte_subset contains subset ADTTE selected time--event endpoint, joined together gene information extracted specified assay experiment, numeric factor columns. factor column created binning numeric column according quantile cutoffs specified probs.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"","code":"adtteSpecServer(   id,   data,   mae_name,   adtte_name,   adtte_vars,   experiment_data,   experiment_name,   assay,   genes,   probs )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. mae_name (string) name MAE data used teal module. adtte_name (string) name ADTTE dataset. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. experiment_data (reactive AnyHermesData) input experiment. experiment_name (reactive string) name input experiment. assay (reactive string) name assay. genes (reactive GeneSpec) gene specification. probs (reactive numeric) probabilities bin gene gene signature .","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"List following elements: binned_adtte_subset: reactive containing joined ADTTE gene data. gene_col: reactive containing string column name original numeric gene variable. gene_factor: string variable name binned gene data. time_unit: reactive string time unit current subset.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/adtteSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for ADTTE Specification — adtteSpecServer","text":"","code":"ui <- function(id) {   ns <- NS(id)    teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = verbatimTextOutput(ns(\"summary\"))   ) }  server <- function(id, data, filter_panel_api) {   checkmate::assert_class(data, \"reactive\")   checkmate::assert_class(shiny::isolate(data()), \"teal_data\")   moduleServer(id, function(input, output, session) {     output$encoding_ui <- renderUI({       tags$div(         experimentSpecInput(session$ns(\"experiment\"), data, mae_name = \"MAE\"),         assaySpecInput(session$ns(\"assay\")),         geneSpecInput(session$ns(\"genes\"), funs = list(Mean = colMeans)),         adtteSpecInput(session$ns(\"adtte\"))       )     })     experiment <- experimentSpecServer(       \"experiment\",       data = data,       filter_panel_api = filter_panel_api,       mae_name = \"MAE\"     )     assay <- assaySpecServer(       \"assay\",       assays = experiment$assays     )     genes <- geneSpecServer(       \"genes\",       funs = list(Mean = colMeans),       gene_choices = experiment$genes     )     adtte <- adtteSpecServer(       \"adtte\",       data = data,       adtte_name = \"ADTTE\",       mae_name = \"MAE\",       adtte_vars = list(         aval = \"AVAL\",         avalu = \"AVALU\",         is_event = \"is_event\",         paramcd = \"PARAMCD\",         usubjid = \"USUBJID\"       ),       experiment_data = experiment$data,       experiment_name = experiment$name,       assay = assay,       genes = genes,       probs = reactive({         0.5       })     )     output$summary <- renderPrint({       binned_adtte_subset <- adtte$binned_adtte_subset()       summary(binned_adtte_subset)     })   }) }  my_app <- function() {   data <- teal_data()   data <- within(data, {     ADSL <- teal.data::rADSL     ADTTE <- teal.modules.hermes::rADTTE %>%       dplyr::mutate(is_event = .data$CNSR == 0)     MAE <- hermes::multi_assay_experiment   })   datanames <- c(\"ADSL\", \"ADTTE\", \"MAE\")   datanames(data) <- datanames   join_keys(data) <- default_cdisc_join_keys[datanames]    app <- init(     data = data,     modules = modules(       module(         label = \"adtteSpec example\",         server = server,         ui = ui,         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) }  if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Assay Specification — assaySpecInput","title":"Module Input for Assay Specification — assaySpecInput","text":"defines input assay specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Assay Specification — assaySpecInput","text":"","code":"assaySpecInput(inputId, label_assays = \"Select Assay\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Assay Specification — assaySpecInput","text":"inputId (string) ID used call module input. label_assays (string) label assay selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Assay Specification — assaySpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Assay Specification — assaySpecServer","title":"Module Server for Assay Specification — assaySpecServer","text":"defines server part assay specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Assay Specification — assaySpecServer","text":"","code":"assaySpecServer(id, assays, exclude_assays = character())"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Assay Specification — assaySpecServer","text":"id (string) shiny module id. assays (reactive character) available assays currently selected experiment. exclude_assays (character) names assays included choices teal module.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Assay Specification — assaySpecServer","text":"chosen assay reactive string.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assaySpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Assay Specification — assaySpecServer","text":"","code":"ui <- function(id) {   ns <- NS(id)   teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = textOutput(ns(\"result\"))   ) }  server <- function(id, data, filter_panel_api) {   moduleServer(id, module = function(input, output, session) {     output$encoding_ui <- renderUI({       tags$div(         experimentSpecInput(session$ns(\"experiment\"), data, \"MAE\"),         assaySpecInput(           session$ns(\"assay\"),           label_assays = \"Please choose assay\"         )       )     })     experiment <- experimentSpecServer(       id = \"experiment\",       data = data,       filter_panel_api = filter_panel_api,       mae_name = \"MAE\"     )     assay <- assaySpecServer(       \"assay\",       experiment$assays,       exclude_assays = c(\"counts\", \"cpm\", \"tpm\", \"bla\")     )     output$result <- renderPrint({       assay()     })   }) }  my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"assaySpec example\",         server = server,         ui = ui,         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_adtte_vars.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for ADTTE Variables — assert_adtte_vars","title":"Check for ADTTE Variables — assert_adtte_vars","text":"Check whether x list ADTTE variables.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_adtte_vars.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for ADTTE Variables — assert_adtte_vars","text":"","code":"assert_adtte_vars(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_adtte_vars.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for ADTTE Variables — assert_adtte_vars","text":"x object check.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_adtte_vars.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for ADTTE Variables — assert_adtte_vars","text":"","code":"assert_adtte_vars(list(aval = \"AV\", is_event = \"EV\", paramcd = \"PC\", usubjid = \"ID\", avalu = \"u\"))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_summary_funs.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for List of Summary Functions — assert_summary_funs","title":"Check for List of Summary Functions — assert_summary_funs","text":"Check whether x list summary functions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_summary_funs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for List of Summary Functions — assert_summary_funs","text":"","code":"assert_summary_funs(x, null.ok = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_summary_funs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for List of Summary Functions — assert_summary_funs","text":"x object check. null.ok (flag) whether x may also contain NULL, meaning user choice possible summary function applied.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assert_summary_funs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for List of Summary Functions — assert_summary_funs","text":"","code":"assert_summary_funs(list(mean = colMeans, raw = NULL), null.ok = TRUE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assertion_arguments.html","id":null,"dir":"Reference","previous_headings":"","what":"Standard Assertion Arguments — assertion_arguments","title":"Standard Assertion Arguments — assertion_arguments","text":"documentation function lists conventional arguments additional checkmate assertions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assertion_arguments.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Standard Assertion Arguments — assertion_arguments","text":"x object check. null.ok (flag) whether x may also NULL. .var.name (string) name checked object print assertions; defaults heuristic implemented checkmate::vname(). add (AssertCollection NULL) collection store assertion messages, see checkmate::AssertCollection. info (string) extra information included message testthat reporter, see testthat::expect_that(). label (string) name checked object print messages. Defaults heuristic implemented checkmate::vname().","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assertions.html","id":null,"dir":"Reference","previous_headings":"","what":"Additional Assertions for checkmate — assertions","title":"Additional Assertions for checkmate — assertions","text":"provide additional assertion functions can used together checkmate functions. described individual help pages linked .","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/assertions.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Additional Assertions for checkmate — assertions","text":"Depending function prefix. assert_ functions return object invisibly successful, otherwise throw error message. check_ functions return TRUE successful, otherwise string error message. test_ functions just return TRUE FALSE.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_reactive.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for Reactive Input — check_reactive","title":"Check for Reactive Input — check_reactive","text":"Check whether x reactive input.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_reactive.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for Reactive Input — check_reactive","text":"","code":"check_reactive(x)  assert_reactive(x, .var.name = checkmate::vname(x), add = NULL)  test_reactive(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_reactive.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for Reactive Input — check_reactive","text":"x object check. .var.name (string) name checked object print assertions; defaults heuristic implemented checkmate::vname(). add (AssertCollection NULL) collection store assertion messages, see checkmate::AssertCollection.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_reactive.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for Reactive Input — check_reactive","text":"","code":"check_reactive(\"bla\") #> [1] FALSE check_reactive(reactive(\"bla\")) #> [1] TRUE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_tag.html","id":null,"dir":"Reference","previous_headings":"","what":"Check for Shiny Tag — check_tag","title":"Check for Shiny Tag — check_tag","text":"Check whether x shiny tag.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_tag.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Check for Shiny Tag — check_tag","text":"","code":"check_tag(x, null.ok = FALSE)  assert_tag(x, null.ok = FALSE, .var.name = checkmate::vname(x), add = NULL)  test_tag(x, null.ok = FALSE)  expect_tag(x, null.ok = FALSE, info = NULL, label = vname(x))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_tag.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Check for Shiny Tag — check_tag","text":"x object check. null.ok (flag) whether x may also NULL. .var.name (string) name checked object print assertions; defaults heuristic implemented checkmate::vname(). add (AssertCollection NULL) collection store assertion messages, see checkmate::AssertCollection. info (string) extra information included message testthat reporter, see testthat::expect_that(). label (string) name checked object print messages. Defaults heuristic implemented checkmate::vname().","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/check_tag.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Check for Shiny Tag — check_tag","text":"","code":"check_tag(\"bla\") #> [1] \"Must be a 'shiny.tag' or NULL\" check_tag(NULL, null.ok = TRUE) #> [1] TRUE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Experiment Specification — experimentSpecInput","title":"Module Input for Experiment Specification — experimentSpecInput","text":"defines input experiment specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Experiment Specification — experimentSpecInput","text":"","code":"experimentSpecInput(   inputId,   data,   mae_name,   label_experiments = \"Select Experiment\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Experiment Specification — experimentSpecInput","text":"inputId (string) ID used call module input. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. mae_name (string) name MAE data used teal module. label_experiments (string) label experiment selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Experiment Specification — experimentSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Experiment Specification — experimentSpecServer","title":"Module Server for Experiment Specification — experimentSpecServer","text":"defines server part experiment specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Experiment Specification — experimentSpecServer","text":"","code":"experimentSpecServer(   id,   data,   filter_panel_api,   mae_name,   name_annotation = \"symbol\",   sample_vars_as_factors = TRUE,   with_mae_col_data = TRUE )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Experiment Specification — experimentSpecServer","text":"id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. mae_name (string) name MAE data used teal module. name_annotation (string NULL) annotation column use name return genes data. NULL, name column set empty strings. sample_vars_as_factors (flag) whether convert sample variables (columns colData() experiment) character factor variables. with_mae_col_data (flag) whether include colData() MAE experiment colData().","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Experiment Specification — experimentSpecServer","text":"List following reactive objects: data: hermes::AnyHermesData experiment. name: name experiment selected user. genes: data.frame genes data, columns id name. assays: names assays data.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/experimentSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Experiment Specification — experimentSpecServer","text":"","code":"ui <- function(id,                mae_name) {   ns <- NS(id)   teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = tags$div(       verbatimTextOutput(ns(\"summary\")),       verbatimTextOutput(ns(\"head\"))     )   ) }  server <- function(id,                    data,                    filter_panel_api,                    mae_name) {   moduleServer(id, function(input, output, session) {     output$encoding_ui <- renderUI({       tags$div(         experimentSpecInput(           session$ns(\"my_experiment\"),           data,           mae_name,           label_experiments = \"Please choose experiment\"         ),         selectInput(           session$ns(\"property\"),           \"Please choose property\",           c(\"data\", \"name\", \"genes\", \"assays\")         )       )     })     experiment <- experimentSpecServer(       \"my_experiment\",       data,       filter_panel_api,       mae_name     )     result <- reactive({       req(input$property)       switch(input$property,         data = experiment$data(),         name = experiment$name(),         genes = experiment$genes(),         assays = experiment$assays()       )     })     output$summary <- renderPrint({       result <- result()       hermes::summary(result)     })     output$head <- renderPrint({       result <- result()       utils::head(result)     })   }) }  my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"experimentSpec example\",         server = server,         server_args = list(mae_name = \"MAE\"),         ui = ui,         ui_args = list(mae_name = \"MAE\"),         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/function_arguments.html","id":null,"dir":"Reference","previous_headings":"","what":"Standard Function Arguments — function_arguments","title":"Standard Function Arguments — function_arguments","text":"documentation function lists conventional arguments functions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/function_arguments.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Standard Function Arguments — function_arguments","text":"adtte (data frame) adtte dataset. usubjid_var (string) variable name subject ID variable. mae (MultiAssayExperiment) contains AnyHermesData objects. object (AnyHermesData) contains RNA-seq values one experiment. genes (GeneSpec) specification gene(s) (signature), e.g. using hermes::gene_spec(). experiment_name (string) desired HermesData use. assay_name (string) assay define groups.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Gene Signature Specification — geneSpecInput","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"defines input gene signature specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"","code":"geneSpecInput(   inputId,   funs,   label_genes = \"Select Gene(s)\",   label_funs = \"Select Gene Summary\",   label_text_button = \"Enter list of genes\",   label_lock_button =     \"Lock gene selection (so that it does not get updated when filtering)\",   label_select_all_button = paste0(\"Select All Genes (first \", max_options, \")\"),   label_select_none_button = \"Select None\",   max_options = 200L,   max_selected = max_options )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"inputId (string) ID used call module input. funs (named list) names list used function selection drop menu. label_genes (string) label gene selection. label_funs (string) label function selection. label_text_button (string) label text input button. label_lock_button (string) label lock button. label_select_all_button (string) label selecting genes button. label_select_none_button (string) label selecting genes button. max_options (count) maximum number gene options rendering selected via \"Select \". max_selected (count) maximum number genes can selected.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecInput.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Input for Gene Signature Specification — geneSpecInput","text":"","code":"geneSpecInput(\"my_genes\", list(mean = colMeans), label_funs = \"Please select function\") #> <div class=\"row\"> #>   <div class=\"col-sm-8\"> #>     <label class=\"control-label\">Select Gene(s)<\/label> #>   <\/div> #>   <div class=\"col-sm-2\"> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_genes-select_none_button\" title=\"Select None\" type=\"button\"> #>       <span> #>         <i aria-label=\"remove-circle icon\" class=\"glyphicon glyphicon-remove-circle\" role=\"presentation\"><\/i> #>       <\/span> #>     <\/button> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_genes-select_all_button\" title=\"Select All Genes (first 200)\" type=\"button\"> #>       <span> #>         <i aria-label=\"ok-circle icon\" class=\"glyphicon glyphicon-ok-circle\" role=\"presentation\"><\/i> #>       <\/span> #>     <\/button> #>   <\/div> #>   <div class=\"col-sm-2\"> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_genes-text_button\" title=\"Enter list of genes\" type=\"button\"> #>       <span> #>         <i class=\"fas fa-font\" role=\"presentation\" aria-label=\"font icon\"><\/i> #>       <\/span> #>     <\/button> #>     <div class=\"pull-right\" title=\"Lock gene selection (so that it does not get updated when filtering)\"> #>       <div class=\"form-group shiny-input-container\"> #>         <div class=\"pretty p-toggle p-plain p-icon p-pulse\"> #>           <input id=\"my_genes-lock_button\" type=\"checkbox\"/> #>           <div class=\"state p-on\"> #>             <i aria-label=\"lock icon\" class=\"fas fa-lock icon\" role=\"presentation\"><\/i> #>             <label> #>               <span><\/span> #>             <\/label> #>           <\/div> #>           <div class=\"state p-off\"> #>             <i aria-label=\"lock-open icon\" class=\"fas fa-lock-open icon\" role=\"presentation\"><\/i> #>             <label> #>               <span><\/span> #>             <\/label> #>           <\/div> #>         <\/div> #>       <\/div> #>     <\/div> #>   <\/div> #> <\/div> #> <div class=\"custom-select-input\"> #>   <div class=\"form-group shiny-input-container\"> #>     <label class=\"control-label shiny-label-null\" for=\"my_genes-genes\" id=\"my_genes-genes-label\"><\/label> #>     <div> #>       <select class=\"shiny-input-select form-control\" id=\"my_genes-genes\" multiple=\"multiple\"><option value=\"\"><\/option><\/select> #>       <script type=\"application/json\" data-for=\"my_genes-genes\" data-eval=\"[&quot;render&quot;]\">{\"placeholder\":\"- Nothing selected -\",\"render\":\"{\\n          option: function(item, escape) {\\n              return '<div> <span style=\\\"font-size: inherit;\\\">' + item.label + '<\\/div>' +\\n                ' <span style=\\\"color: #808080; font-size: xx-small;\\\" >' + item.value + '<\\/div> <\\/div>'\\n            }\\n          }\",\"searchField\":[\"value\",\"label\"],\"maxOptions\":200,\"maxItems\":200,\"plugins\":[\"selectize-plugin-a11y\"]}<\/script> #>     <\/div> #>   <\/div> #> <\/div> #> <div class=\"shiny-panel-conditional\" data-display-if=\"input.genes &amp;&amp; input.genes.length &gt; 1\" data-ns-prefix=\"my_genes-\"> #>   <div class=\"form-group shiny-input-container\"> #>     <label class=\"control-label\" id=\"my_genes-fun_name-label\" for=\"my_genes-fun_name\">Please select function<\/label> #>     <div> #>       <select id=\"my_genes-fun_name\" class=\"shiny-input-select\"><option value=\"mean\" selected>mean<\/option><\/select> #>       <script type=\"application/json\" data-for=\"my_genes-fun_name\" data-nonempty=\"\">{\"plugins\":[\"selectize-plugin-a11y\"]}<\/script> #>     <\/div> #>   <\/div> #> <\/div>"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Gene Signature Specification — geneSpecServer","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"defines server part gene signature specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"","code":"geneSpecServer(   id,   funs,   gene_choices,   label_modal_title = \"Enter list of genes\",   label_modal_footer = c(\"Please enter a comma-separated list of gene IDs and/or names.\",     \"(Note that genes not included in current choices will be removed)\") )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"id (string) shiny module id. funs (static named list) names list used function selection drop menu. gene_choices (reactive data.frame) returns possible gene choices populate UI, data.frame columns id name. label_modal_title (string) title dialog asks text input. label_modal_footer (character) lines text use footer dialog.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"Reactive hermes::GeneSpec can used input relevant hermes functions.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/geneSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Gene Signature Specification — geneSpecServer","text":"","code":"ui <- function(id, funs) {   ns <- NS(id)   teal.widgets::standard_layout(     encoding = tags$div(       geneSpecInput(         ns(\"my_genes\"),         funs = funs,         label_funs = \"Please select function\"       )     ),     output = textOutput(ns(\"result\"))   ) } server <- function(id,                    data,                    funs) {   checkmate::assert_class(data, \"reactive\")   checkmate::assert_class(shiny::isolate(data()), \"teal_data\")   moduleServer(id, function(input, output, session) {     gene_choices <- reactive({       mae <- data()[[\"MAE\"]]       object <- mae[[1]]       gene_ids <- rownames(object)       gene_names <- SummarizedExperiment::rowData(object)$symbol       gene_data <- data.frame(         id = gene_ids,         name = gene_names       )       gene_data[order(gene_data$name), ]     })     gene_spec <- geneSpecServer(       \"my_genes\",       funs = funs,       gene_choices = gene_choices     )     output$result <- renderText({       validate_gene_spec(         gene_spec(),         gene_choices()$id       )       gene_spec <- gene_spec()       gene_spec$get_label()     })   }) } funs <- list(mean = colMeans) my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"GeneSpec example\",         server = server,         server_args = list(funs = funs),         ui = ui,         ui_args = list(funs = funs),         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_assign_to_group_list.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function For Group List Creation — h_assign_to_group_list","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"helper function takes assignment list converts group list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_assign_to_group_list.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"","code":"h_assign_to_group_list(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_assign_to_group_list.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"x (named list character) input assignment list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_assign_to_group_list.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"combination list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_assign_to_group_list.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function For Group List Creation — h_assign_to_group_list","text":"","code":"assign_list <- list(   \"ASIAN\" = \"1\",   \"BLACK OR AFRICAN AMERICAN\" = \"1\",   \"MULTIPLE\" = \"2\",   \"UNKNOWN\" = \"2\",   \"WHITE\" = \"4\" ) objective_list <- list(   \"ASIAN/BLACK OR AFRICAN AMERICAN\" = c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\"),   \"MULTIPLE/UNKNOWN\" = c(\"MULTIPLE\", \"UNKNOWN\"),   \"WHITE\" = \"WHITE\" ) result_list <- h_assign_to_group_list(assign_list) stopifnot(identical(result_list, objective_list))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_collapse_levels.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"Given group list factor, helper function collapses levels factor accordingly also ensures resulting levels order given group list.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_collapse_levels.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"","code":"h_collapse_levels(x, group_list)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_collapse_levels.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"x (factor) original factor. group_list (named list character) includes collapsing specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_collapse_levels.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"transformed factor x new levels.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_collapse_levels.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function for Collapsing of Factor Levels — h_collapse_levels","text":"","code":"set.seed(123) x <- factor(sample(   c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\", \"MULTIPLE\", \"UNKNOWN\", \"WHITE\"),   size = 30L,   replace = TRUE )) group_list <- list(   \"ASIAN/BLACK OR AFRICAN AMERICAN\" = c(\"ASIAN\", \"BLACK OR AFRICAN AMERICAN\"),   \"MULTIPLE/UNKNOWN\" = c(\"MULTIPLE\", \"UNKNOWN\"),   \"WHITE\" = \"WHITE\" ) x_collapsed <- h_collapse_levels(x, group_list) stopifnot(identical(levels(x_collapsed), names(group_list)))"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_extract_words.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Extract Words — h_extract_words","title":"Helper Function to Extract Words — h_extract_words","text":"helper function extracts words string. words defined containing lower upper case letters, colons dots. characters considered separators.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_extract_words.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Extract Words — h_extract_words","text":"","code":"h_extract_words(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_extract_words.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Extract Words — h_extract_words","text":"x (string) input.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_extract_words.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Extract Words — h_extract_words","text":"Character vector extracted words.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_extract_words.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Extract Words — h_extract_words","text":"","code":"h_extract_words(\"a, b, , c, 234; 34562 - GeneID:bla\") #> [1] \"a\"          \"b\"          \"c\"          \"234\"        \"34562\"      #> [6] \"GeneID:bla\" h_extract_words(\"GeneID:1820, sdf.393; 32596\") #> [1] \"GeneID:1820\" \"sdf.393\"     \"32596\""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_gene_data.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Format Gene Choices — h_gene_data","title":"Helper Function to Format Gene Choices — h_gene_data","text":"Given hermes::AnyHermesData data object, well annotation column name use gene name, function formats contained genes data.frame ready consumption h_order_genes() e.g.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_gene_data.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Format Gene Choices — h_gene_data","text":"","code":"h_gene_data(object, name_annotation)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_gene_data.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Format Gene Choices — h_gene_data","text":"object (AnyHermesData) contains RNA-seq values one experiment. name_annotation (string NULL) annotation column use name return genes data. NULL, name column set empty strings.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_gene_data.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Format Gene Choices — h_gene_data","text":"data.frame id name columns containing genes object.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_gene_data.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Helper Function to Format Gene Choices — h_gene_data","text":"Note missing names names contain whitespace replaced empty strings consistency better labeling UI downstream","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_gene_data.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Format Gene Choices — h_gene_data","text":"","code":"object <- hermes::hermes_data[1:10, ] h_gene_data(object, \"symbol\") #>                  id         name #> 1      GeneID:11185         INMT #> 2      GeneID:10677         AVIL #> 3  GeneID:101928428 LOC101928428 #> 4  GeneID:100422835      MIR3183 #> 5  GeneID:102466731     MIR6769A #> 6      GeneID:64881       PCDH20 #> 7     GeneID:286205         SCAI #> 8       GeneID:8365     HIST1H4H #> 9       GeneID:6804        STX1A #> 10 GeneID:100423018    MIR3156-3"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_km_mae_to_adtte.html","id":null,"dir":"Reference","previous_headings":"","what":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"function help merging MAE ADTTE.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_km_mae_to_adtte.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"","code":"h_km_mae_to_adtte(   adtte,   mae,   genes,   experiment_name = \"hd1\",   assay_name = \"counts\",   usubjid_var = \"USUBJID\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_km_mae_to_adtte.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"adtte (data frame) adtte dataset. mae (MultiAssayExperiment) contains AnyHermesData objects. genes (GeneSpec) specification gene(s) (signature), e.g. using hermes::gene_spec(). experiment_name (string) desired HermesData use. assay_name (string) assay define groups. usubjid_var (string) variable name subject ID variable.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_km_mae_to_adtte.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"data frame containing columns/rows adtte match subject ID row names MAE gene samples available given experiment. attribute gene_cols contains column names gene columns.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_km_mae_to_adtte.html","id":"note","dir":"Reference","previous_headings":"","what":"Note","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"final gene column names can start different string original gene IDs (labels), particular white space colons removed.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_km_mae_to_adtte.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Data Preprocessing for ADTTE Module — h_km_mae_to_adtte","text":"","code":"mae <- hermes::multi_assay_experiment adtte <- teal.modules.hermes::rADTTE %>%   dplyr::mutate(CNSR = as.logical(CNSR))  new_adtte <- h_km_mae_to_adtte(   adtte,   mae,   genes = hermes::gene_spec(\"GeneID:1820\"),   experiment_name = \"hd2\" ) new_adtte2 <- h_km_mae_to_adtte(   adtte,   mae,   genes = hermes::gene_spec(c(\"GeneID:1820\", \"GeneID:94115\"), fun = colMeans),   experiment_name = \"hd2\" ) new_adtte3 <- h_km_mae_to_adtte(   adtte,   mae,   genes = hermes::gene_spec(c(A = \"GeneID:1820\", B = \"GeneID:94115\")),   experiment_name = \"hd2\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_order_genes.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Order Gene Choices — h_order_genes","title":"Helper Function to Order Gene Choices — h_order_genes","text":"possible gene choices ordered follows. First come genes non-empty name, ordered name alphabetically. Last come genes empty name, ordered ID alphabetically.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_order_genes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Order Gene Choices — h_order_genes","text":"","code":"h_order_genes(genes)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_order_genes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Order Gene Choices — h_order_genes","text":"genes (data.frame) containing id name columns gene choices. Note missing values allowed.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_order_genes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Order Gene Choices — h_order_genes","text":"ordered data.frame.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_order_genes.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Order Gene Choices — h_order_genes","text":"","code":"genes <- data.frame(   id = c(\"7\", \"1\", \"2\", \"345346\", \"0\"),   name = c(\"e\", \"\", \"c\", \"\", \"a\") ) h_order_genes(genes) #>       id name #> 5      0    a #> 3      2    c #> 1      7    e #> 2      1      #> 4 345346"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_parse_genes.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Parse Genes — h_parse_genes","title":"Helper Function to Parse Genes — h_parse_genes","text":"helper function takes vector words tries match id name columns possible gene choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_parse_genes.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Parse Genes — h_parse_genes","text":"","code":"h_parse_genes(words, choices)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_parse_genes.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Parse Genes — h_parse_genes","text":"words (character) containing gene IDs names. choices (data.frame) containing id name columns new choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_parse_genes.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Helper Function to Parse Genes — h_parse_genes","text":"subset choices matches words ID name.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_parse_genes.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Helper Function to Parse Genes — h_parse_genes","text":"","code":"h_parse_genes(   c(\"a\", \"2535\"),   data.frame(id = as.character(2533:2537), name = letters[1:5]) ) #>     id name #> 1 2533    a #> 3 2535    c"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_update_gene_selection.html","id":null,"dir":"Reference","previous_headings":"","what":"Helper Function to Update Gene Selection — h_update_gene_selection","title":"Helper Function to Update Gene Selection — h_update_gene_selection","text":"helper function takes intersection selected choices genes updates inputId accordingly. shows notification selected genes available.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_update_gene_selection.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Helper Function to Update Gene Selection — h_update_gene_selection","text":"","code":"h_update_gene_selection(session, inputId, selected, choices)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/h_update_gene_selection.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Helper Function to Update Gene Selection — h_update_gene_selection","text":"session (ShinySession) session object. inputId (string) ID used call module input. selected (character) currently selected gene IDs. choices (data.frame) containing id name columns new choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/heatmap_plot.html","id":null,"dir":"Reference","previous_headings":"","what":"Correlation Heatmap Plot — heatmap_plot","title":"Correlation Heatmap Plot — heatmap_plot","text":"function plots correlation heatmap.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/heatmap_plot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Correlation Heatmap Plot — heatmap_plot","text":"","code":"heatmap_plot(object, assay_name)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/heatmap_plot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Correlation Heatmap Plot — heatmap_plot","text":"object (AnyHermesData) contains RNA-seq values one experiment. assay_name (string) assay define groups.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/heatmap_plot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Correlation Heatmap Plot — heatmap_plot","text":"Plot displayed teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/heatmap_plot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Correlation Heatmap Plot — heatmap_plot","text":"","code":"library(hermes) #> Loading required package: ggfortify #> Loading required package: SummarizedExperiment #> Loading required package: MatrixGenerics #> Loading required package: matrixStats #>  #> Attaching package: ‘MatrixGenerics’ #> The following objects are masked from ‘package:matrixStats’: #>  #>     colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse, #>     colCounts, colCummaxs, colCummins, colCumprods, colCumsums, #>     colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs, #>     colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats, #>     colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds, #>     colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads, #>     colWeightedMeans, colWeightedMedians, colWeightedSds, #>     colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet, #>     rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods, #>     rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps, #>     rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins, #>     rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks, #>     rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars, #>     rowWeightedMads, rowWeightedMeans, rowWeightedMedians, #>     rowWeightedSds, rowWeightedVars #> Loading required package: GenomicRanges #> Loading required package: stats4 #> Loading required package: BiocGenerics #>  #> Attaching package: ‘BiocGenerics’ #> The following objects are masked from ‘package:stats’: #>  #>     IQR, mad, sd, var, xtabs #> The following objects are masked from ‘package:base’: #>  #>     Filter, Find, Map, Position, Reduce, anyDuplicated, aperm, append, #>     as.data.frame, basename, cbind, colnames, dirname, do.call, #>     duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted, #>     lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin, #>     pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table, #>     tapply, union, unique, unsplit, which.max, which.min #> Loading required package: S4Vectors #>  #> Attaching package: ‘S4Vectors’ #> The following object is masked from ‘package:utils’: #>  #>     findMatches #> The following objects are masked from ‘package:base’: #>  #>     I, expand.grid, unname #> Loading required package: IRanges #> Loading required package: GenomeInfoDb #> Loading required package: Biobase #> Welcome to Bioconductor #>  #>     Vignettes contain introductory material; view with #>     'browseVignettes()'. To cite Bioconductor, see #>     'citation(\"Biobase\")', and for packages 'citation(\"pkgname\")'. #>  #> Attaching package: ‘Biobase’ #> The following object is masked from ‘package:MatrixGenerics’: #>  #>     rowMedians #> The following objects are masked from ‘package:matrixStats’: #>  #>     anyMissing, rowMedians #>  #> Attaching package: ‘hermes’ #> The following object is masked from ‘package:stats’: #>  #>     filter object <- HermesData(summarized_experiment) result <- heatmap_plot(object, assay_name = \"counts\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_css_files.html","id":null,"dir":"Reference","previous_headings":"","what":"Include CSS files from /inst/css/ package directory to application header — include_css_files","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"system.file used access files packages, work devtools. Therefore, redefine method package needed. Thus, export method","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_css_files.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"","code":"include_css_files(pattern = \"*\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_css_files.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"pattern (character) pattern files included","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_css_files.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Include CSS files from /inst/css/ package directory to application header — include_css_files","text":"HTML code includes CSS files","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_js_files.html","id":null,"dir":"Reference","previous_headings":"","what":"Include JS files from /inst/js/ package directory to application header — include_js_files","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"system.file used access files packages, work devtools. Therefore, redefine method package needed. Thus, export method","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_js_files.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"","code":"include_js_files(pattern = \"*\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_js_files.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"pattern (character) pattern files included, passed system.file except (character) vector basename filenames excluded","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/include_js_files.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Include JS files from /inst/js/ package directory to application header — include_js_files","text":"HTML code includes JS files","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/is_blank.html","id":null,"dir":"Reference","previous_headings":"","what":"Checking for Empty String — is_blank","title":"Checking for Empty String — is_blank","text":"predicate function helpful functions arguments yet initialized teal module.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/is_blank.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Checking for Empty String — is_blank","text":"","code":"is_blank(x)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/is_blank.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Checking for Empty String — is_blank","text":"x object check.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/is_blank.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Checking for Empty String — is_blank","text":"Flag whether x identical empty string, .e. \"\".","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/is_blank.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Checking for Empty String — is_blank","text":"","code":"is_blank(\"\") #> [1] TRUE is_blank(\" \") #> [1] FALSE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/module_arguments.html","id":null,"dir":"Reference","previous_headings":"","what":"Standard Module Arguments — module_arguments","title":"Standard Module Arguments — module_arguments","text":"documentation function lists conventional arguments hermes teal modules.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/module_arguments.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Standard Module Arguments — module_arguments","text":"data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. label (string) menu item label module teal app. inputId (string) ID used call module input. adtte_name (string) name ADTTE dataset. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . reporter (Reporter) object pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). id (string) shiny module id. plot_height (list) list integers set default, minimum, maximum plot height. plot_width (list) list integers set default, minimum, maximum plot width. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. .test (flag) whether display internal structure plot testing purposes.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/multiSampleVarSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"multiple sample variables used given module, wrapper makes much easier specify server function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/multiSampleVarSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"","code":"multiSampleVarSpecServer(inputIds, original_data, ...)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/multiSampleVarSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"inputIds (character) multiple input IDs corresponding different sample variables specified UI function. original_data (reactive SummarizedExperiment) input experiment sample variables extracted via SummarizedExperiment::colData() eligible selection. ... additional arguments documented sampleVarSpecServer(), namely mandatory experiment_name optional categorical_only, num_levels label_modal_title. transformed_data assign_lists specified already specified internally .","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/multiSampleVarSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"List final transformed experiment_data reactive list vars contains selected sample variables reactives input ID.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/multiSampleVarSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Specification of Multiple Sample Variables — multiSampleVarSpecServer","text":"","code":"if (FALSE) { # In the server use: sample_var_specs <- multiSampleVarSpecServer(   inputIds = c(\"facet_var\", \"color_var\"),   experiment_name = reactive({     input$experiment_name   }),   original_data = ori_data # nolint Please update the <ori_data> ) # Then can extract the transformed data and selected variables later: experiment_data <- sample_var_specs$experiment_data() facet_var <- sample_var_specs$vars$facet_var() color_var <- sample_var_specs$vars$color_var() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/rADTTE.html","id":null,"dir":"Reference","previous_headings":"","what":"Random Time to Event Analysis Dataset — rADTTE","title":"Random Time to Event Analysis Dataset — rADTTE","text":"Random Time Event Analysis Dataset","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/rADTTE.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Random Time to Event Analysis Dataset — rADTTE","text":"","code":"rADTTE"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/rADTTE.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Random Time to Event Analysis Dataset — rADTTE","text":"object class tbl_df (inherits tbl, data.frame) 2000 rows 67 columns.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/rADTTE.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Random Time to Event Analysis Dataset — rADTTE","text":"internal","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecInput.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Input for Sample Variable Specification — sampleVarSpecInput","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"defines input sample variable specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecInput.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"","code":"sampleVarSpecInput(   inputId,   label_vars = \"Select sample variable\",   label_levels_button = \"Combine factor levels\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecInput.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"inputId (string) ID used call module input. label_vars (string) label sample variable selection. label_levels_button (string) label levels combination button.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecInput.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"UI part.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecInput.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Input for Sample Variable Specification — sampleVarSpecInput","text":"","code":"sampleVarSpecInput(\"my_vars\", label_vars = \"Select faceting variable\") #> <div class=\"row\"> #>   <div class=\"col-sm-8\"> #>     <label class=\"control-label\">Select faceting variable<\/label> #>   <\/div> #>   <div class=\"col-sm-4\"> #>     <button class=\"btn btn-default action-button pull-right list-genes\" id=\"my_vars-levels_button\" title=\"Combine factor levels\" type=\"button\"> #>       <span> #>         <i class=\"fas fa-table\" role=\"presentation\" aria-label=\"table icon\"><\/i> #>       <\/span> #>     <\/button> #>   <\/div> #> <\/div> #> <div class=\"custom-select-input\"> #>   <div> #>     <script> #>         $(function() { #>           $('#my_vars-sample_var').on('change', function(e) { #>             var select_concat = $(this).val().length ? $(this).val().join(', ') : 'NULL'; #>             $('#my_vars-sample_var_selected_text').html(select_concat); #>           }) #>         })<\/script> #>     <div> #>       <div id=\"my_vars-sample_var_input\" style=\"display: block;\"> #>         <div class=\"form-group shiny-input-container\"> #>           <label class=\"control-label shiny-label-null\" for=\"my_vars-sample_var\" id=\"my_vars-sample_var-label\"><\/label> #>           <select data-actions-box=\"false\" data-none-selected-text=\"- Nothing selected -\" data-max-options=\"1\" data-show-subtext=\"true\" data-live-search=\"false\" data-state-input=\"true\" id=\"my_vars-sample_var\" class=\"selectpicker form-control\" autocomplete=\"off\" multiple=\"multiple\"><option value=\"\"><\/option><\/select> #>         <\/div> #>       <\/div> #>       <div id=\"my_vars-sample_var_fixed\" style=\"display: none;\"> #>         <label class=\"control-label\"><\/label> #>         <code id=\"my_vars-sample_var_selected_text\">NULL<\/code> #>       <\/div> #>     <\/div> #>   <\/div> #> <\/div>"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecServer.html","id":null,"dir":"Reference","previous_headings":"","what":"Module Server for Sample Variable Specification — sampleVarSpecServer","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"defines server part sample variable specification.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecServer.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"","code":"sampleVarSpecServer(   id,   experiment_name,   original_data,   transformed_data = original_data,   assign_lists = reactiveValues(),   num_levels = NULL,   categorical_only = !is.null(num_levels),   explicit_na = FALSE,   label_modal_title = \"Please click to group the original factor levels\" )"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecServer.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"id (string) shiny module id. experiment_name (reactive string) name input experiment. original_data (reactive SummarizedExperiment) input experiment sample variables extracted via SummarizedExperiment::colData() eligible selection. transformed_data (reactive SummarizedExperiment) used multiple sample variables can selected app. case, pass pre-transformed data. assign_lists (reactivevalues) object share factor level groupings across multiple sample variables. num_levels (count NULL) required number levels combining original levels. NULL numbers levels allowed. categorical_only (flag) whether categorical variables selected . explicit_na (flag) whether colData original_data transformed hermes::h_df_factors_with_explicit_na processing. means also NA made explicit factor level counted num_levels. label_modal_title (string) title dialog asks text input.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecServer.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"Reactive SummarizedExperiment::SummarizedExperiment can used input relevant hermes functions.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecServer.html","id":"note","dir":"Reference","previous_headings":"","what":"Note","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"atomic columns (e.g. DataFrame columns) colData completely missing (NA) shown selection. num_levels specified factor columns available.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/sampleVarSpecServer.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Module Server for Sample Variable Specification — sampleVarSpecServer","text":"","code":"ui <- function(id) {   checkmate::assert_class(data, \"teal_data\")   ns <- NS(id)    teal.widgets::standard_layout(     encoding = uiOutput(ns(\"encoding_ui\")),     output = plotOutput(ns(\"plot\"))   ) } server <- function(id,                    data) {   checkmate::assert_class(data, \"reactive\")   checkmate::assert_class(shiny::isolate(data()), \"teal_data\")   moduleServer(id, function(input, output, session) {     output$encoding_ui <- renderUI({       mae <- data()[[\"MAE\"]]       experiment_name_choices <- names(mae)       tags$div(         selectInput(session$ns(\"experiment_name\"), \"Select experiment\", experiment_name_choices),         sampleVarSpecInput(session$ns(\"facet_var\"), \"Select faceting variable\")       )     })     experiment_data <- reactive({       req(input$experiment_name)       mae <- data()[[\"MAE\"]]       object <- mae[[input$experiment_name]]       SummarizedExperiment::colData(object) <-         hermes::df_cols_to_factor(SummarizedExperiment::colData(object))       object     })     facet_var_spec <- sampleVarSpecServer(       \"facet_var\",       experiment_name = reactive({         input$experiment_name       }),       original_data = experiment_data     )     output$plot <- renderPlot({       experiment_data_final <- facet_var_spec$experiment_data()       facet_var <- facet_var_spec$sample_var()       hermes::draw_boxplot(         experiment_data_final,         assay_name = \"counts\",         genes = hermes::gene_spec(hermes::genes(experiment_data_final)[1]),         facet_var = facet_var       )     })   }) } my_app <- function() {   data <- teal_data(MAE = hermes::multi_assay_experiment)   app <- init(     data = data,     modules = modules(       module(         label = \"sampleVarSpec example\",         server = server,         ui = ui,         datanames = \"all\"       )     )   )   shinyApp(app$ui, app$server) } if (interactive()) {   my_app() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/teal.modules.hermes-package.html","id":null,"dir":"Reference","previous_headings":"","what":"teal.modules.hermes Package — teal.modules.hermes-package","title":"teal.modules.hermes Package — teal.modules.hermes-package","text":"teal.modules.hermes provides RNA-seq analysis modules add teal application.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/teal.modules.hermes-package.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"teal.modules.hermes Package — teal.modules.hermes-package","text":"Maintainer: Daniel Sabanés Bové daniel.sabanes_bove@roche.com Authors: Nikolas Burkoff Dinakar Kulkarni Konrad Pagacz Namrata Bhatia Dawid Kaledkowski Pawel Rucki Jeff Luong Stefanie Bienert Haocheng Li Lyndsee Midori Zhang contributors: Sorin Voicu [contributor] Benoit Falquet [contributor] Mahmoud Hallal [contributor] Tim Treis [contributor] Vedha Viyash [contributor] F. Hoffmann-La Roche AG [copyright holder, funder]","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_barplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Barplot — tm_g_barplot","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"module provides interactive barplot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_barplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"","code":"tm_g_barplot(   label,   mae_name,   exclude_assays = character(),   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_barplot(   id,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_barplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   summary_funs,   .test = FALSE )  sample_tm_g_barplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_barplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_barplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_barplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"ui_g_barplot(): sets user interface. srv_g_barplot(): sets server reactive graph. sample_tm_g_barplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_barplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Barplot — tm_g_barplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_barplot(       label = \"barplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_barplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_barplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_boxplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"module provides interactive boxplot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_boxplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"","code":"tm_g_boxplot(   label,   mae_name,   exclude_assays = character(),   summary_funs = list(None = NULL, Mean = colMeans, Median = matrixStats::colMedians, Max     = matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_boxplot(   id,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_boxplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   summary_funs,   .test = FALSE )  sample_tm_g_boxplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_boxplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_boxplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_boxplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"ui_g_boxplot(): sets user interface. srv_g_boxplot(): sets server reactive graph. sample_tm_g_boxplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_boxplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Boxplot — tm_g_boxplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_boxplot(       label = \"boxplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_boxplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_boxplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_forest_tte.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for Survival Forest Plot — tm_g_forest_tte","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"module provides interactive survival forest plot.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_forest_tte.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"","code":"tm_g_forest_tte(   label,   adtte_name,   mae_name,   adtte_vars = list(aval = \"AVAL\", is_event = \"is_event\", paramcd = \"PARAMCD\", usubjid =     \"USUBJID\", avalu = \"AVALU\"),   exclude_assays = \"counts\",   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   plot_height = c(600L, 200L, 2000L),   plot_width = c(1360L, 500L, 2000L),   .test = FALSE )  ui_g_forest_tte(   id,   adtte_name,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_forest_tte(   id,   data,   filter_panel_api,   reporter,   adtte_name,   mae_name,   adtte_vars,   exclude_assays,   summary_funs,   plot_height,   plot_width,   .test = FALSE )  sample_tm_g_forest_tte(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_forest_tte.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"label (string) menu item label module teal app. adtte_name (string) name ADTTE dataset. mae_name (string) name MAE data used teal module. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). plot_height (list) list integers set default, minimum, maximum plot height. plot_width (list) list integers set default, minimum, maximum plot width. .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_forest_tte.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_forest_tte.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"ui_g_forest_tte(): sets user interface. srv_g_forest_tte(): sets server reactive graph. sample_tm_g_forest_tte(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_forest_tte.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for Survival Forest Plot — tm_g_forest_tte","text":"","code":"data <- teal_data() data <- within(data, {   ADTTE <- teal.modules.hermes::rADTTE %>%     dplyr::mutate(is_event = .data$CNSR == 0)   MAE <- hermes::multi_assay_experiment }) datanames <- c(\"ADTTE\", \"MAE\") datanames(data) <- datanames join_keys(data)[\"ADTTE\", \"ADTTE\"] <- c(\"STUDYID\", \"USUBJID\", \"PARAMCD\")  app <- init(   data = data,   modules = modules(     tm_g_forest_tte(       label = \"forestplot\",       adtte_name = \"ADTTE\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_forest_tte if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_forest_tte() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_km.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for Kaplan-Meier Plot — tm_g_km","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"teal module produces grid style Kaplan-Meier plot data ADaM structure.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_km.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"","code":"tm_g_km(   label,   adtte_name,   mae_name,   adtte_vars = list(aval = \"AVAL\", is_event = \"is_event\", paramcd = \"PARAMCD\", usubjid =     \"USUBJID\", avalu = \"AVALU\"),   exclude_assays = \"counts\",   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_km(   id,   adtte_name,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_km(   id,   data,   filter_panel_api,   reporter,   adtte_name,   mae_name,   adtte_vars,   summary_funs,   exclude_assays,   .test = FALSE )  sample_tm_g_km(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_km.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"label (string) menu item label module teal app. adtte_name (string) name ADTTE dataset. mae_name (string) name MAE data used teal module. adtte_vars (named list string) names variables use ADTTE dataset. comprise elements: aval: numeric time--event variable. avalu: variable holding unit aval. is_event: logical event variable. needs TRUE observed event, FALSE time censored without observed event. paramcd: character factor parameter code variable, defining type time--event selection module. usubjid: subject ID variable. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_km.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_km.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"ui_g_km(): sets user interface. srv_g_km(): sets user interface. sample_tm_g_km(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_km.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for Kaplan-Meier Plot — tm_g_km","text":"","code":"data <- teal_data() data <- within(data, {   ADTTE <- teal.modules.hermes::rADTTE %>%     dplyr::mutate(is_event = .data$CNSR == 0)   MAE <- hermes::multi_assay_experiment }) datanames <- c(\"ADTTE\", \"MAE\") datanames(data) <- datanames join_keys(data)[\"ADTTE\", \"ADTTE\"] <- c(\"STUDYID\", \"USUBJID\", \"PARAMCD\")   modules <- modules(   tm_g_km(     label = \"kaplan-meier\",     adtte_name = \"ADTTE\",     mae_name = \"MAE\"   ) ) #> Initializing tm_g_km  app <- init(   data = data,   modules = modules )  if (interactive()) {   shinyApp(ui = app$ui, server = app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_km() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_pca.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for PCA Analysis — tm_g_pca","title":"Teal Module for PCA Analysis — tm_g_pca","text":"module provides interactive principal components plot interactive heatmap correlation principal components sample variables.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_pca.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for PCA Analysis — tm_g_pca","text":"","code":"tm_g_pca(   label,   mae_name,   exclude_assays = character(),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_pca(id, mae_name, pre_output, post_output, .test = FALSE)  srv_g_pca(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   .test = FALSE )  sample_tm_g_pca(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_pca.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for PCA Analysis — tm_g_pca","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_pca.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for PCA Analysis — tm_g_pca","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_pca.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for PCA Analysis — tm_g_pca","text":"ui_g_pca(): sets user interface. srv_g_pca(): sets server reactive graph. sample_tm_g_pca(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_pca.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for PCA Analysis — tm_g_pca","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_pca(       label = \"PCA plot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_pca if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_pca() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_quality.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Quality Control — tm_g_quality","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"module adds quality flags, filters genes /samples, normalizes AnyHermesData objects provides interactive plots RNA-seq gene expression quality control.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_quality.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"","code":"tm_g_quality(   label,   mae_name,   exclude_assays = character(),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_quality(id, mae_name, pre_output, post_output, .test = FALSE)  srv_g_quality(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   .test = FALSE )  sample_tm_g_quality(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_quality.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_quality.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_quality.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"ui_g_quality(): sets user interface. srv_g_quality(): sets server reactive graphs. sample_tm_g_quality(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_quality.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Quality Control — tm_g_quality","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_quality(       label = \"Quality Control\",       mae_name = \"MAE\"     )   ) ) if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_quality() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_scatterplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"module provides interactive scatterplot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_scatterplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"","code":"tm_g_scatterplot(   label,   mae_name,   exclude_assays = \"counts\",   summary_funs = list(Mean = colMeans, Median = matrixStats::colMedians, Max =     matrixStats::colMaxs),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_scatterplot(   id,   mae_name,   summary_funs,   pre_output,   post_output,   .test = FALSE )  srv_g_scatterplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   summary_funs,   .test = FALSE )  sample_tm_g_scatterplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_scatterplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. summary_funs (named list functions NULL) functions can used gene signatures. modules support also multiple genes without summary, NULL can included summarize genes provide . pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_scatterplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_scatterplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"ui_g_scatterplot(): sets user interface. srv_g_scatterplot(): sets server reactive graph. sample_tm_g_scatterplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_scatterplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Scatterplot — tm_g_scatterplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_scatterplot(       label = \"scatterplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_scatterplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_scatterplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_volcanoplot.html","id":null,"dir":"Reference","previous_headings":"","what":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"module provides interactive volcano plot RNA-seq gene expression analysis.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_volcanoplot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"","code":"tm_g_volcanoplot(   label,   mae_name,   exclude_assays = character(),   pre_output = NULL,   post_output = NULL,   .test = FALSE )  ui_g_volcanoplot(id, mae_name, pre_output, post_output, .test = FALSE)  srv_g_volcanoplot(   id,   data,   filter_panel_api,   reporter,   mae_name,   exclude_assays,   .test = FALSE )  sample_tm_g_volcanoplot(.test = FALSE)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_volcanoplot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"label (string) menu item label module teal app. mae_name (string) name MAE data used teal module. exclude_assays (character) names assays included choices teal module. pre_output (shiny.tag NULL) placed output put output context (example title). post_output (shiny.tag NULL) placed output put output context (example shiny::helpText() elements can useful). .test (flag) whether display internal structure plot testing purposes. id (string) shiny module id. data (reactive)reactive(<teal_data>) holding data sets provided app initialization going filters. filter_panel_api (FilterPanelAPI) object describing actual filter panel API. reporter (Reporter) object","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_volcanoplot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"Shiny module used teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_volcanoplot.html","id":"functions","dir":"Reference","previous_headings":"","what":"Functions","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"ui_g_volcanoplot(): sets user interface. srv_g_volcanoplot(): sets server reactive graph. sample_tm_g_volcanoplot(): sample module function.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/tm_g_volcanoplot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Teal Module for RNA-seq Volcano Plot — tm_g_volcanoplot","text":"","code":"data <- teal_data(MAE = hermes::multi_assay_experiment) app <- init(   data = data,   modules = modules(     tm_g_volcanoplot(       label = \"volcanoplot\",       mae_name = \"MAE\"     )   ) ) #> Initializing tm_g_volcanoplot if (interactive()) {   shinyApp(app$ui, app$server) }  # Alternatively you can run the sample module with this function call: if (interactive()) {   sample_tm_g_volcanoplot() }"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/top_gene_plot.html","id":null,"dir":"Reference","previous_headings":"","what":"Most Expressed Genes Plot — top_gene_plot","title":"Most Expressed Genes Plot — top_gene_plot","text":"function plots expressed genes.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/top_gene_plot.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Most Expressed Genes Plot — top_gene_plot","text":"","code":"top_gene_plot(object, assay_name)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/top_gene_plot.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Most Expressed Genes Plot — top_gene_plot","text":"object (AnyHermesData) contains RNA-seq values one experiment. assay_name (string) assay define groups.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/top_gene_plot.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Most Expressed Genes Plot — top_gene_plot","text":"Plot displayed teal app.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/top_gene_plot.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Most Expressed Genes Plot — top_gene_plot","text":"","code":"library(hermes) object <- HermesData(summarized_experiment) result <- top_gene_plot(object, assay_name = \"counts\")"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/validate_gene_spec.html","id":null,"dir":"Reference","previous_headings":"","what":"Validation of Gene Specification — validate_gene_spec","title":"Validation of Gene Specification — validate_gene_spec","text":"validation function checks given hermes::GeneSpec least one gene selected genes included possible choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/validate_gene_spec.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Validation of Gene Specification — validate_gene_spec","text":"","code":"validate_gene_spec(gene_spec, gene_choices)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/validate_gene_spec.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Validation of Gene Specification — validate_gene_spec","text":"gene_spec (GeneSpec) gene specification. gene_choices (character) possible gene choices.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/validate_n_levels.html","id":null,"dir":"Reference","previous_headings":"","what":"Validation of Number of Levels — validate_n_levels","title":"Validation of Number of Levels — validate_n_levels","text":"validation function checks given vector x factor specified number levels.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/validate_n_levels.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Validation of Number of Levels — validate_n_levels","text":"","code":"validate_n_levels(x, name, n_levels)"},{"path":"https://insightsengineering.github.io/teal.modules.hermes/reference/validate_n_levels.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Validation of Number of Levels — validate_n_levels","text":"x (factor) factor validate. name (string) name x app. n_levels (count) required number factor levels x.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"miscellaneous-0-1-6-9010","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.6.9010","text":"Added placeholders assaySpec, adtteSpec geneSpec inputs option selected. Disabled select input assaySpec adtteSpec options available. module developers: module gets teal_data object UI reactive(<teal_data>) server","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"enhancements-0-1-6-9010","dir":"Changelog","previous_headings":"","what":"Enhancements","title":"teal.modules.hermes 0.1.6.9010","text":"Updated documentation vignettes new way specifying data teal::init(). data argument accepts teal_data object.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"bug-fixes-0-1-5","dir":"Changelog","previous_headings":"","what":"Bug Fixes","title":"teal.modules.hermes 0.1.5","text":"Filtering data filter panel now correctly triggers sampleVarSpecModule.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"breaking-changes-0-1-5","dir":"Changelog","previous_headings":"","what":"Breaking changes","title":"teal.modules.hermes 0.1.5","text":"Replaced datasets argument containing FilteredData new arguments data (tdata object) filter_panel_api (FilterPanelAPI).","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"miscellaneous-0-1-5","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.5","text":"Removed scda dependencies. Migrate shinytest2.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"tealmoduleshermes-014","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.4","title":"teal.modules.hermes 0.1.4","text":"Added teal.reporter functionality modules. Add installation instruction","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"tealmoduleshermes-013","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.3","title":"teal.modules.hermes 0.1.3","text":"Improve selection sample variables forest module (tm_g_forest_tte) categorical variables can selected first place.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"miscellaneous-0-1-3","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.3","text":"Added template pkgdown site. Updated package authors. Added option categorical_only sampleVarSpec server module, allows show categorical sample variables selection.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"tealmoduleshermes-012","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.2","title":"teal.modules.hermes 0.1.2","text":"Rewrote modules use moduleServer updated call plot_with_settings_srv changes teal.devel. Replaced calls teal::root_modules teal::modules following deprecation teal::root_modules. Added basic logging modules. Fixed geneSpecInput hermes app doesn’t fail anymore (chrome) experiment genes.","code":""},{"path":[]},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"bug-fixes-0-1-1","dir":"Changelog","previous_headings":"","what":"Bug Fixes","title":"teal.modules.hermes 0.1.1","text":"Updated legend PCA plot. Gene selection thousand genes longer hangs application. achieved different selection input corresponding geneSpec shiny module. atomic columns colData least one value can now selected sampleVarSpecModule.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"miscellaneous-0-1-1","dir":"Changelog","previous_headings":"","what":"Miscellaneous","title":"teal.modules.hermes 0.1.1","text":"Updated R version requirement >= 3.6. Updated sampleVarSpec geneSpec modules new icons remove warnings using shiny version >= 1.7. Removed dependencies deprecated packages utils.nest test.nest.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"tealmoduleshermes-010","dir":"Changelog","previous_headings":"","what":"teal.modules.hermes 0.1.0","title":"teal.modules.hermes 0.1.0","text":"First release teal.modules.hermes package, contains teal modules RNA-seq analysis using hermes package. New users first begin reading README.md teal.modules.hermes package become familiar.","code":""},{"path":"https://insightsengineering.github.io/teal.modules.hermes/news/index.html","id":"new-features-0-1-0","dir":"Changelog","previous_headings":"","what":"New Features","title":"teal.modules.hermes 0.1.0","text":"tm_g_barplot barplot module RNA-seq gene expression analysis. tm_g_boxplot boxplot module RNA-seq gene expression analysis. tm_g_forest_tte survival forest plot module analyze RNA-seq gene expression data together survival data. tm_g_km Kaplan-Meier plot module analyze RNA-seq gene expression data together survival data. tm_g_pca principal components analysis plot module RNA-seq gene expression analysis. tm_g_quality quality control module RNA-seq gene expression data. tm_g_scatterplot scatterplot module RNA-seq gene expression analysis. tm_g_volcanoplot differential gene expression analysis module.","code":""}]