[Feature Request]: landmark endpoints with 95% CI

[zhangq47]

Feature description

Hi, I am in RWDS and appreciate very much using the TEAL4REAL app that Michael Bretscher built for Flatiron RWD analysis. Navi Pal continued on the effort and we are analyzing RWD for early-stage NSCLC (eNSCLC). The eNSCLC patients live relatively longer than late-stage patients, so instead of real-world OS or PFS, the endpoints in eNSCLC are usually landmark endpoints, eg DFS (disease-free survival) and RFS (recurrence-free survival) at 2-, 3-, or 5-year with 95% CI. Can that be added to the TEAL package? Thanks!

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[donyunardi]

Hi @zhangq47

Since OS and PFS are typically controls available in the encoding area of a teal module, I believe you're requesting additional value to the endpoints choices or a new encoding category to control your visualization or output.

Am I correct to assume this?

[zhangq47]

Hi, Sorry for the very late reply. I was traveling when I started replying but never got to finish it and send it... Yes, you are correct. I am asking for 1-yr, 2-yr, 3-yr, 4-yr, 5-yr, etc landmark %survival endpoints. In the example below, Figure panel A, the vertical lines at 12, 24, 36, 48, and 60 months showed Pembro+chemo %survival as 69.8, 45.7, 31.3, 23.6, and 19.4%. Can this be done, and can 95% CI be included as well? And while we are talking about non-time-to-event endpoints (such as OS, PFS, RFS...), is RR (response rate, also in % format) available or can RR be added? Thanks! Qing

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On Mon, Apr 8, 2024 at 7:20 PM Dony Unardi ***@***.***> wrote: Hi @zhangq47 <https://github.com/zhangq47> Since OS and PFS are typically controls available in the encoding area of a teal module, I believe you're requesting additional value to the endpoints choices or a new encoding category to control your visualization or output. image.png (view on web) <https://github.com/insightsengineering/teal/assets/8597300/e2877f52-3600-4c54-be68-0340effaf1e2> Am I correct to assume this? — Reply to this email directly, view it on GitHub <#1232>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AC54ZTUECPHPXOFH2JG7FODY4NF75AVCNFSM6AAAAABFWBJSF6VHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDANBUGAZTKNBYGA> . You are receiving this because you were mentioned.Message ID: ***@***.***>

-- *Qing Zhang*, Ph.D. | Senior Principal Data Scientist RWDS (Real World Data Science) PDD (Product Development Data Sciences) Genentech, *A Member of the Roche Group * 1 DNA Way, South San Francisco, CA 94080 ***@***.*** | Cell 650-580-4477

[donyunardi]

Hi @shajoezhu @Melkiades,

Can the request be easily fulfilled by passing additional value to one of the module's arguments, or does it require further customization of the related teal module?

[m7pr]

ping @Melkiades

[donyunardi]

I'm going to move this to teal.modules.clinical to get a proper attention.

@zhangq47 could you also provide information which teal module that you're using?