diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 2ba72d664..6f4d77f2c 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -88,3 +88,7 @@ repos:
   hooks:
     - id: isort
       name: isort (python)
+- repo: https://github.com/asottile/yesqa
+  rev: v1.5.0
+  hooks:
+    - id: yesqa
diff --git a/girder/girder_large_image/rest/large_image_resource.py b/girder/girder_large_image/rest/large_image_resource.py
index 2814b2212..652e58b38 100644
--- a/girder/girder_large_image/rest/large_image_resource.py
+++ b/girder/girder_large_image/rest/large_image_resource.py
@@ -112,7 +112,7 @@ def cursorNextOrNone(cursor):
     :returns: the next value or None.
     """
     try:
-        return cursor.next()  # noqa - B305
+        return cursor.next()
     except StopIteration:
         return None
 
@@ -577,7 +577,7 @@ def configValidate(self, config):
         config = config.read().decode('utf8')
         return self._configValidate(config)
 
-    @autoDescribeRoute(  # noqa
+    @autoDescribeRoute(
         Description('Reformat a Girder config file')
         .param('config', 'The contents of config file to format.',
                paramType='body'),
diff --git a/large_image/cache_util/cache.py b/large_image/cache_util/cache.py
index f6eeeb14a..d2e57a811 100644
--- a/large_image/cache_util/cache.py
+++ b/large_image/cache_util/cache.py
@@ -117,7 +117,7 @@ class LruCacheMetaclass(type):
     namedCaches = {}
     classCaches = {}
 
-    def __new__(metacls, name, bases, namespace, **kwargs):  # noqa - N804
+    def __new__(metacls, name, bases, namespace, **kwargs):
         # Get metaclass parameters by finding and removing them from the class
         # namespace (necessary for Python 2), or preferentially as metaclass
         # arguments (only in Python 3).
diff --git a/large_image/tilesource/__init__.py b/large_image/tilesource/__init__.py
index 7ac8c2545..4ace39d79 100644
--- a/large_image/tilesource/__init__.py
+++ b/large_image/tilesource/__init__.py
@@ -145,7 +145,7 @@ def getTileSourceFromDict(availableSources, pathOrUri, *args, **kwargs):
     sourceName = getSourceNameFromDict(availableSources, pathOrUri, *args, **kwargs)
     if sourceName:
         return availableSources[sourceName](pathOrUri, *args, **kwargs)
-    if not os.path.exists(pathOrUri) and '://' not in pathOrUri:
+    if not os.path.exists(pathOrUri) and '://' not in str(pathOrUri):
         raise TileSourceFileNotFoundError(pathOrUri)
     raise TileSourceError('No available tilesource for %s' % pathOrUri)
 
diff --git a/large_image/tilesource/base.py b/large_image/tilesource/base.py
index fa11d3437..89d985f16 100644
--- a/large_image/tilesource/base.py
+++ b/large_image/tilesource/base.py
@@ -995,7 +995,7 @@ def _pilFormatMatches(self, image, match=True, **kwargs):
         # compatibility could be an issue.
         return False
 
-    @methodcache()  # noqa
+    @methodcache()
     def histogram(self, dtype=None, onlyMinMax=False, bins=256,  # noqa
                   density=False, format=None, *args, **kwargs):
         """